531 results on '"Singh, Sheldon M"'
Search Results
152. Esophageal Injury and Temperature Monitoring During Atrial Fibrillation Ablation
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Singh, Sheldon M., primary, d'Avila, Andre, additional, Doshi, Shephal K., additional, Brugge, William R., additional, Bedford, Rudolph A., additional, Mela, Theofanie, additional, Ruskin, Jeremy N., additional, and Reddy, Vivek Y., additional
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- 2008
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153. Barriers to Influenza Vaccination in Patients with Implantable Cardiac Defibrillators.
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Turner, Suzette, De Souza, Russell J., Kumareswaran, Ramanan, and Singh, Sheldon M.
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Background: Multiple studies have demonstrated a reduction of cardiovascular events in patients who receive the annual influenza vaccine. Despite recommendations from cardiovascular societies, influenza vaccination remains suboptimal in the implantable cardioverter defibrillator (ICD) population. Barriers to receiving the influenza vaccination have not been explored. Purpose: To evaluate the barriers to receiving the influenza vaccine in patients with ICDs. Design: Exploratory descriptive design using a survey developed by the staff of the ICD clinic. Procedure: A pilot study was conducted as part of a quality initiative of ICD patients at a regional cardiac centre. These patients were approached to participate in a one-page survey assessing barriers to receipt of the influenza vaccination. Predictors of vaccination were determined using multivariate logistic regression. Findings: Of the 229 patients who completed the survey between September 1 and November 31, 2011, 78% of the patients received the influenza vaccine. The only factor independently associated with influenza vaccination was a positive patient attitude toward the safety of influenza vaccination. Easier access to the influenza vaccination was not associated with its receipt. Conclusion: A positive patient attitude toward the influenza vaccine is associated with its use. ICD clinic practitioners may have an opportunity to explore any misconceptions toward the influenza vaccine at each clinic visit in hope of increasing its receipt. Given the importance of this vaccination, future studies are recommended. [ABSTRACT FROM AUTHOR]
- Published
- 2015
154. Magnetic resonance imaging of the left atrial appendage post pulmonary vein isolation: Implications for percutaneous left atrial appendage occlusion.
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Singh, Sheldon M., Jimenez‐Juan, Laura, Danon, Asaf, Bastarrika, Gorka, Shmatukha, Andriy V., Wright, Graham A., and Crystal, Eugene
- Abstract
Background There is increasing interest in performing left atrial appendage (LAA) occlusion at the time of atrial fibrillation (AF) ablation procedures. However, to date there has been no description of the acute changes to the LAA immediately following pulmonary vein (PV) isolation and additional left atrium (LA) substrate modification. This study assessed changes in the size and tissue characteristics of the LAA ostium in patients undergoing PV isolation. Methods This series included 8 patients who underwent cardiovascular magnetic resonance evaluation of the LA with delayed enhancement magnetic resonance imaging and contrast enhanced 3-D magnetic resonance angiography pre-, within 48 h of, and 3 months post ablation. Two independent cardiac radiologists evaluated the ostial LAA diameters and area at each time point in addition to the presence of gadolinium enhancement. Results Compared to pre-ablation values, the respective median differences in oblique diameters and LAA area were +1.8 mm, +1.7 mm, and +0.6 cm 2 immediately post ablation (all NS) and −2.7 mm, −2.3 mm, and −0.5 cm 2 at 3 months (all NS). No delayed enhancement was detected in the LAA post ablation. Conclusion No significant change to LAA diameter, area, or tissue characteristics was noted after PV isolation. While these findings suggest the safety and feasibility of concomitant PV isolation and LAA device occlusion, the variability in the degree and direction of change of the LAA measurements highlights the need for further study. [ABSTRACT FROM AUTHOR]
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- 2015
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155. Anatomy Assessment for Atrial Arrhythmias.
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Singh, Sheldon M. and d'Avila, Andre
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- 2012
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156. Association between mortality and occupation among movie directors and actors
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Redelmeier, Donald A, primary and Singh, Sheldon M, additional
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- 2003
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157. Advances in Left Atrial Appendage Occlusion Strategies.
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Aryana, Arash, Singh, Sheldon M., Doshi, Shephal K., and d'Avila, André
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ATRIAL fibrillation , *LIGATURE (Surgery) , *BLOOD coagulation , *ORAL medicine , *THERAPEUTIC embolization , *PREVENTION - Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and associated with an elevated risk of thromboembolic stroke and systemic embolization. The evidence suggests that ~90% of thrombi in patients with non-valvular AF are localized to the left atrial appendage (LAA). Therefore, it seems reasonable to consider LAA exclusion in selected patients with AF for stroke prevention. LAA exclusion can be achieved through a variety of surgical and percutaneous techniques. Surgical methods include LAA amputation, ligation, clipping and stapling. Whereas percutaneous strategies consist of endocardial closure using an LAA occlusion device and epicardial LAA ligation using a snare device. Even though several trials and registries of LAA exclusion have yielded promising outcomes, at this time evidence for long term safety and efficacy seems insufficient to recommend this approach to all patients with non-valvular AF. Future prospective randomized trials are needed to assess the precise role for these therapeutic options. Furthermore, there is a paucity of data on the comparison of these strategies to the novel oral anticoagulants which also deserves further attention. This review will carefully examine the current LAA exclusion techniques and the available data. [ABSTRACT FROM AUTHOR]
- Published
- 2013
158. Relation Between Previous Angiotensin-Converting Enzyme Inhibitor Use and In-Hospital Outcomes in Acute Coronary Syndromes
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Singh, Sheldon M., Goodman, Shaun G., Yan, Raymond T., Dery, Jean-Pierre, Wong, Graham C., Gallo, Richard, Grondin, Francois R., Lai, Kevin, Lopez-Sendon, Jose, Fox, Keith A.A., and Yan, Andrew T.
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ACUTE coronary syndrome , *ANGIOTENSIN converting enzyme , *CORONARY disease , *MYOCARDIAL infarction risk factors , *LOGISTIC regression analysis , *HEART failure - Abstract
Angiotensin-converting enzyme (ACE) inhibitor use in patients at high risk of coronary artery disease has been associated with a decrease in the risk of myocardial infarction (MI) and death. However, it is unclear whether chronic use of these agents modifies the course and outcome of an acute coronary syndrome (ACS). This study assessed the association between chronic use of ACE inhibitors and clinical outcomes in patients with ACS. From 1999 through 2008, 13,632 Canadian patients with ACS were identified in the Global Registry of Acute Coronary Events (GRACE), the expanded GRACE (GRACE2), and the Canadian Registry of Acute Coronary Events (CANRACE). Patients were stratified by previous use of an ACE inhibitor. Clinical characteristics, in-hospital treatment, and outcomes were compared between the 2 groups. Multivariable logistic regression analysis adjusting for GRACE risk score and other clinical factors was performed. Patients receiving an ACE inhibitor before the ACS had a higher prevalence of diabetes (40.6% vs 21.2%, p <0.001), previous MI (51.8% vs 23.3%, p <0.001), heart failure (18.0% vs 6.9%), and higher GRACE scores at presentation (133 vs 124, p <0.001). Multivariable analysis demonstrated no significant association between previous ACE inhibitor use and death (adjusted odds ratio [OR] 1.15, confidence interval [CI] 0.90 to 1.49, p = 0.27), in-hospital re-MI (adjusted OR 0.99, CI 0.78 to 1.25, p = 0.91), or the composite end point of death/re-MI (adjusted OR 1.01, CI 0.84 to 1.20, p = 0.94). In conclusion, previous use of an ACE inhibitor is not independently associated with improved in-hospital outcomes after an ACS. [Copyright &y& Elsevier]
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- 2012
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159. Ventricular Tachycardia Ablation: Are We Winning the Battle But Losing the War?
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d’Avila, Andre, Singh, Sheldon M., and d'Avila, Andre
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VENTRICULAR tachycardia , *CATHETER ablation , *HEMODYNAMICS , *CLINICAL trials , *HEART failure , *DISEASE relapse , *HEART beat - Published
- 2016
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160. An uncommon ECG manifestation of normal pacemaker function.
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Kumar, Sharath K., Morgan, Christopher D., Jordan‐Watt, Michael, and Singh, Sheldon M.
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A presumed abnormal electrocardiogram (ECG) was obtained from an asymptomatic patient with a pacemaker. Systematic evaluation of the ECG revealed that the artifact was due to a physiological sensor in the pacemaker which was displayed when the enhanced pacemaker detection features on the ECG machine was activated. The article discusses the possible causes and an approach to similar artifacts. [ABSTRACT FROM AUTHOR]
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- 2020
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161. ABSTRACTS.
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Ben-Tovim, David I., Thomas, Vince Salazar, Rockwood, Kenneth J., McNamara, Dennis M., Douketis, James D., Paulson, Richard J., Redelmeier, Donald A., Singh, Sheldon M., Elkayam, Uri, Baeten, Jared M., Ness, Roberta B., Wang, Steven Q., Cohen, David, Valenstein, Paul N., Greenes, David S., Fleisher, Gary R., Marcoval, Joaquim, Parsa, Cameron F., and Rosenberg, Lynn
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EATING disorders ,HEALTH of older people ,PREGNANCY complications - Abstract
Presents a number of medical abstracts as of July 4, 2001. Outcome in patients with eating disorders; Alcohol abuse, cognitive impairment, and mortality among older people; HIV-infected pregnant women and vertical transmission in Europe since 1986; More.
- Published
- 2001
162. Occult arterial bleeding associated with cardiac device implantation.
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Demirtas, Abdullah O., Sanhueza, Eduardo, and Singh, Sheldon M.
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HEMATOMA , *IMPLANTABLE cardioverter-defibrillators , *THERAPEUTIC embolization , *CARDIAC pacing , *FECAL occult blood tests , *ENDOVASCULAR surgery , *HEMORRHAGE - Abstract
Introduction: The appearance of hematomas or hemorrhages after the implantation of a cardiac implantable electronic device (CIEDs) is a well‐known early complication, which can be associated with reinterventions, infections, readmissions, and longer hospital stays. Occasionally, these bleedings may correspond to arterial hemorrhages, which require early identification and specific treatment. We reviewed two clinical cases of inadvertent arterial bleeding after Pacemaker implantation that required a high clinical suspicion together with a multidisciplinary evaluation of cardiologists, radiologists and interventional medicine that allowed a fast and effective endovascular approach. [ABSTRACT FROM AUTHOR]
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- 2022
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163. High‐power short‐duration versus low‐power long‐duration ablation for pulmonary vein isolation: A substudy of the AWARE randomized controlled trial.
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Joza, Jacqueline, Nair, Girish M., Birnie, David H., Nery, Pablo B., Redpath, Calum J., Sarrazin, Jean‐Francois, Champagne, Jean, Bernick, Jordan, Wells, George A., Essebag, Vidal, Roux, Jean‐Francois, Dussault, Charles, Parkash, Ratika, Bernier, Martin, Sterns, Laurence D., Sapp, John, Novak, Paul, Veenhuyzen, George, Morillo, Carlos A., and Singh, Sheldon M.
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CONFIDENCE intervals , *ATRIAL fibrillation , *CATHETER ablation , *TREATMENT duration , *REGRESSION analysis , *TREATMENT effectiveness , *COMPARATIVE studies , *DESCRIPTIVE statistics , *ELECTROCARDIOGRAPHY , *RESEARCH funding , *PULMONARY veins , *PATIENT safety , *EVALUATION - Abstract
Introduction: Pulmonary vein isolations (PVI) are being performed using a high‐power, short‐duration (HPSD) strategy. The purpose of this study was to compare the clinical efficacy and safety outcomes of an HPSD versus low‐power, long‐duration (LPLD) approach to PVI in patients with paroxysmal atrial fibrillation (AF). Methods: Patients were grouped according to a HPSD (≥40 W) or LPLD (≤35 W) strategy. The primary endpoint was the 1‐year recurrence of any atrial arrhythmia lasting ≥30 s, detected using three 14‐day ambulatory continuous ECG monitoring. Procedural and safety endpoints were also evaluated. The primary analysis were regression models incorporating propensity scores yielding adjusted relative risk (RRa) and mean difference (MDa) estimates. Results: Of the 398 patients included in the AWARE Trial, 173 (43%) underwent HPSD and 225 (57%) LPLD ablation. The distribution of power was 50 W in 75%, 45 W in 20%, and 40 W in 5% in the HPSD group, and 35 W with 25 W on the posterior wall in the LPLD group. The primary outcome was not statistically significant at 30.1% versus 22.2% in HPSD and LPLD groups with RRa 0.77 (95% confidence interval [CI]) 0.55–1.10; p =.165). The secondary outcome of repeat catheter ablation was not statistically significant at 6.9% and 9.8% (RRa 1.59 [95% CI 0.77–3.30]; p =.208) respectively, nor was the incidence of any ECG documented AF during the blanking period: 1.7% versus 8.0% (RRa 3.95 [95% CI 1.00–15.61; p =.049) in the HPSD versus LPLD group respectively. The total procedure time was significantly shorter in the HPSD group (MDa 97.5 min [95% CI 84.8–110.4)]; p <.0001) with no difference in adjudicated serious adverse events. Conclusions: An HPSD strategy was associated with significantly shorter procedural times with similar efficacy in terms of clinical arrhythmia recurrence. Importantly, there was no signal for increased harm with a HPSD strategy. [ABSTRACT FROM AUTHOR]
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- 2024
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164. Cardiovascular magnetic resonance guided ablation and intra-procedural visualization of evolving radiofrequency lesions in the left ventricle.
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Krahn, Philippa R. P., Singh, Sheldon M., Ramanan, Venkat, Biswas, Labonny, Yak, Nicolas, Anderson, Kevan J. T., Barry, Jennifer, Pop, Mihaela, and Wright, Graham A.
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DIAGNOSIS of edema , *LEFT heart ventricle , *ANIMAL experimentation , *CARDIOVASCULAR disease diagnosis , *CATHETER ablation , *MAGNETIC resonance imaging , *SWINE , *VENTRICULAR tachycardia , *DESCRIPTIVE statistics , *COMPUTER-aided diagnosis , *WOUNDS & injuries - Abstract
Background: Radiofrequency (RF) ablation has become a mainstay of treatment for ventricular tachycardia, yet adequate lesion formation remains challenging. This study aims to comprehensively describe the composition and evolution of acute left ventricular (LV) lesions using native-contrast cardiovascular magnetic resonance (CMR) during CMR-guided ablation procedures. Methods: RF ablation was performed using an actively-tracked CMR-enabled catheter guided into the LV of 12 healthy swine to create 14 RF ablation lesions. T2 maps were acquired immediately post-ablation to visualize myocardial edema at the ablation sites and T1-weighted inversion recovery prepared balanced steady-state free precession (IR-SSFP) imaging was used to visualize the lesions. These sequences were repeated concurrently to assess the physiological response following ablation for up to approximately 3 h. Multi-contrast late enhancement (MCLE) imaging was performed to confirm the final pattern of ablation, which was then validated using gross pathology and histology. Results: Edema at the ablation site was detected in T2 maps acquired as early as 3 min post-ablation. Acute T2-derived edematous regions consistently encompassed the T1-derived lesions, and expanded significantly throughout the 3-h period post-ablation to 1.7 ± 0.2 times their baseline volumes (mean ± SE, estimated using a linear mixed model determined from
n = 13 lesions). T1-derived lesions remained approximately stable in volume throughout the same time frame, decreasing to 0.9 ± 0.1 times the baseline volume (mean ± SE, estimated using a linear mixed model,n = 9 lesions). Conclusions: Combining native T1- and T2-based imaging showed that distinctive regions of ablation injury are reflected by these contrast mechanisms, and these regions evolve separately throughout the time period of an intervention. An integrated description of the T1-derived lesion and T2-derived edema provides a detailed picture of acute lesion composition that would be most clinically useful during an ablation case. [ABSTRACT FROM AUTHOR]- Published
- 2018
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165. Left atrial--esophageal istula after atrial fibrillation ablation.
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Singh, Sheldon M. and Nault, Isabelle
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FISTULA ,ESOPHAGUS diseases ,SURGICAL complications ,COMPLICATIONS of cardiac surgery ,COMPUTED tomography - Abstract
The article offers information on left atrial-esophageal fistula as a complication of atrial ablation. It relates the susceptibility of the esophagus to thermal injury during ablation procedures. It discusses the use of computed tomography in diagnosing atrial-esophageal fistula. It emphasizes the importance of prompt surgical intervention to improve survival and minimize morbidity.
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- 2013
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166. Abstract 259
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Wijeysundera, Harindra C, Qiu, Feng, Micieli, Andrew, Bennell, Maria C, Atzema, Clare, Ko, Dennis T, Dorian, Paul, and Singh, Sheldon M
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Background:The dramatic increase in the incidence of atrial fibrillation (AF) has substantial impacts on health care resource utilization. Our objective was to understand the pattern and predictors of cumulative health care costs in patients with incident AF.
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- 2014
167. An Atypical Presentation of a Typical Arrhythmia.
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SHAUER, AYELET, DANON, ASAF, and SINGH, SHELDON M.
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ARRHYTHMIA treatment , *CARDIAC pacing , *CATHETER ablation , *THREE-dimensional imaging - Abstract
The article describes the case of a 44 year old man with a long history of a narrow complex tachycardia and prior left lateral accessory pathway (LL-AP) ablation presented to the electrophysiology laboratory for a redo supraventricular tachycardia (SVT) ablation procedure. It notes that the case highlights the diagnostic challenge that occurs in case of recurrence of LL-AP in the setting of mitral annular block.
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- 2016
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168. Impact of Peridevice Leak on 5-Year Outcomes After Left Atrial Appendage Closure.
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Dukkipati, Srinivas R., Holmes, David R., Doshi, Shephal K., Kar, Saibal, Singh, Sheldon M., Gibson, Douglas, Price, Matthew J., Natale, Andrea, Mansour, Moussa, Sievert, Horst, Houle, Vicki M., Allocco, Dominic J., Reddy, Vivek Y., and Holmes, David R Jr
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LEFT heart atrium , *ATRIAL fibrillation , *TRANSESOPHAGEAL echocardiography , *ISCHEMIC stroke , *ECHOCARDIOGRAPHY , *STROKE prevention , *EMBOLISM prevention , *WARFARIN , *CARDIAC catheterization , *STROKE , *LEFT atrial appendage closure , *ANTICOAGULANTS , *EMBOLISMS , *TREATMENT effectiveness , *HEART atrium , *THROMBOEMBOLISM , *DISEASE complications ,CARDIOVASCULAR disease related mortality - Abstract
Background: In the U.S. Food and Drug Administration (FDA) clinical trials of left atrial appendage (LAA) closure, a postimplantation peridevice leak (PDL) of ≤5 mm (PDL≤5) was accepted as sufficient LAA "closure." However, the clinical consequences of these PDLs on subsequent thromboembolism are poorly characterized.Objectives: We sought to assess the impact of PDL≤5 on clinical outcomes after implantation of the Watchman device.Methods: Using combined data from the FDA studies PROTECT-AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation), PREVAIL (Evaluation of the Watchman Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation vs Long Term Warfarin Therapy), and CAP2 (Continued Access to PREVAIL), we assessed patients with successful device implantation for PDL by means of protocol-mandated transesophageal echocardiograms (TEEs) at 45 days and 1 year. Five-year outcomes were assessed as a function of the absence or presence of PDL≤5.Results: The cohort included 1,054 patients: mean age 74 ± 8.3 years, 65% male, and CHA2DS2-VASc 4.1 ± 1.4. TEE imaging at 45 days revealed 634 patients (60.2%) without and 404 (38.3%) with PDL≤5, and 1-year TEE revealed 704 patients (71.6%) without and 272 (27.7%) with PDL≤5. The presence of PDL≤5 at 1 year, but not at 45 days, was associated with an increased 5-year risk of ischemic stroke or systemic embolism (adjusted HR: 1.94; 95% CI: 1.15-3.29; P = 0.014), largely driven by an increase in nondisabling stroke (HR: 1.97; 95% CI: 1.03-3.78; P = 0.04), while disabling or fatal stroke rates were similar (HR: 0.69; 95% CI: 0.19-2.46; P = 0.56). PDL≤5 was not associated with an increased risk of cardiovascular or unexplained death (HR: 1.20; P = 0.45) or all-cause death (HR: 0.87; P = 0.42).Conclusions: PDL≤5 at 1 year after percutaneous LAA closure with the Watchman device are associated with increased thromboembolism, driven by increased nondisabling stroke, but similar mortality. (Watchman Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation [PROTECT-AF; NCT00129545]; Evaluation of the Watchman Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation vs Long Term Warfarin Therapy [PREVAIL; NCT01182441]; Continued Access to PREVAIL [CAP2; NCT01760291]). [ABSTRACT FROM AUTHOR]- Published
- 2022
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169. MRI-Guided Cardiac RF Ablation for Comparing MRI Characteristics of Acute Lesions and Associated Electrophysiologic Voltage Reductions.
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Krahn, Philippa R. P., Biswas, Labonny, Ferguson, Sebastian, Ramanan, Venkat, Barry, Jennifer, Singh, Sheldon M., Pop, Mihaela, and Wright, Graham A.
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ARRHYTHMIA , *MAGNETIC resonance imaging , *VENTRICULAR tachycardia , *VOLTAGE , *DIFFERENTIABLE dynamical systems , *RADIO frequency , *IMAGE registration - Abstract
Objective: Radiofrequency (RF) energy delivered to cardiac tissue produces a core ablation lesion with surrounding edema, the latter of which has been implicated in acute procedural failure of Ventricular Tachycardia (VT) ablation and late arrhythmia recurrence. This study sought to investigate the electrophysiological characteristics of acute RF lesions in the left ventricle (LV) visualized with native-contrast Magnetic Resonance Imaging (MRI). Methods: An MR-guided electrophysiology system was used to deliver RF ablation in the LV of 8 swine (9 RF lesions in total), then perform MRI and electroanatomic mapping. The permanent RF lesions and transient edema were delineated via native-contrast MRI segmentation of T1-weighted images and T2 maps respectively. Bipolar voltage measurements were matched with image characteristics of pixels adjacent to the catheter tip. Native-contrast MR visualization was verified with 3D late gadolinium enhanced MRI and histology. Results: The T2-derived edema was significantly larger than the T1-derived RF lesion (2.1 $\pm$ 1.5 mL compared to 0.58 $\pm$ 0.34 mL; p=0.01). Bipolar voltage was significantly reduced in the presence of RF lesion core (p $< $ 0.05) and edema (p $< $ 0.05), with similar trends suggesting that both the permanent lesion and transient edema contributed to the region of reduced voltage. While bipolar voltage was significantly decreased where RF lesions are present (p $< $ 0.05), voltage did not change significantly with lesion transmurality (p $>$ 0.05). Conclusion: Permanent RF lesions and transient edema are distinct in native-contrast MR images, but not differentiable using bipolar voltage. Significance: Intraprocedural native-contrast MRI may provide valuable lesion assessment in MR-guided ablation, whose clinical application is now feasible. [ABSTRACT FROM AUTHOR]
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- 2022
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170. Prognostic value of cardiovascular magnetic resonance left ventricular volumetry and geometry in patients receiving an implantable cardioverter defibrillator.
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Urzua Fresno, Camila M., Folador, Luciano, Shalmon, Tamar, Hamad, Faisal Mhd. Dib, Singh, Sheldon M., Karur, Gauri R., Tan, Nigel S., Mangat, Iqwal, Kirpalani, Anish, Chacko, Binita Riya, Jimenez-Juan, Laura, Yan, Andrew T., and Deva, Djeven P.
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LEFT heart ventricle , *VENTRICULAR ejection fraction , *SCIENTIFIC observation , *CONFIDENCE intervals , *CARDIOMYOPATHIES , *MULTIVARIATE analysis , *MAGNETIC resonance imaging , *IMPLANTABLE cardioverter-defibrillators , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *CARDIOVASCULAR disease diagnosis , *LONGITUDINAL method , *PROPORTIONAL hazards models ,MORTALITY risk factors - Abstract
Background: Current indications for implantable cardioverter defibrillator (ICD) implantation for sudden cardiac death prevention rely primarily on left ventricular (LV) ejection fraction (LVEF). Currently, two different contouring methods by cardiovascular magnetic resonance (CMR) are used for LVEF calculation. We evaluated the comparative prognostic value of these two methods in the ICD population, and if measures of LV geometry added predictive value. Methods: In this retrospective, 2-center observational cohort study, patients underwent CMR prior to ICD implantation for primary or secondary prevention from January 2005 to December 2018. Two readers, blinded to all clinical and outcome data assessed CMR studies by: (a) including the LV trabeculae and papillary muscles (TPM) (trabeculated endocardial contours), and (b) excluding LV TPM (rounded endocardial contours) from the total LV mass for calculation of LVEF, LV volumes and mass. LV sphericity and sphere-volume indices were also calculated. The primary outcome was a composite of appropriate ICD shocks or death. Results: Of the 372 consecutive eligible patients, 129 patients (34.7%) had appropriate ICD shock, and 65 (17.5%) died over a median duration follow-up of 61 months (IQR 38–103). LVEF was higher when including TPM versus excluding TPM (36% vs. 31%, p < 0.001). The rate of appropriate ICD shock or all-cause death was higher among patients with lower LVEF both including and excluding TPM (p for trend = 0.019 and 0.004, respectively). In multivariable models adjusting for age, primary prevention, ischemic heart disease and late gadolinium enhancement, both LVEF (HR per 10% including TPM 0.814 [95%CI 0.688–0.962] p = 0.016, vs. HR per 10% excluding TPM 0.780 [95%CI 0.639–0.951] p = 0.014) and LV mass index (HR per 10 g/m2 including TPM 1.099 [95%CI 1.027–1.175] p = 0.006; HR per 10 g/m2 excluding TPM 1.126 [95%CI 1.032–1.228] p = 0.008) had independent prognostic value. Higher LV end-systolic volumes and LV sphericity were significantly associated with increased mortality but showed no added prognostic value. Conclusion: Both CMR post-processing methods showed similar prognostic value and can be used for LVEF assessment. LVEF and indexed LV mass are independent predictors for appropriate ICD shocks and all-cause mortality in the ICD population. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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171. Metabolic cardiomyopathy from propionic acidemia precipitating cardiac arrest in a 25-year-old man.
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Tan, Nigel S., Bajaj, Ravi R., Morel, Chantal, and Singh, Sheldon M.
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ACIDOSIS , *CARDIOPULMONARY resuscitation , *DEFIBRILLATORS , *CARDIAC arrest , *HEART diseases , *BIOLOGICAL tags - Abstract
The article presents a case study of 25-year-old man with a medical history of propionic acidemia as he collapsed while jogging. He received immediate by stander cardiopulmonary resuscitation and was defibrillated by paramedics from an initial rhythm of ventricular fibrillation. At the time of the patient's witnessed cardiac arrest, initial laboratory investigations showed an anion gap metabolic acidosis and lactic acidemia. and hematologic profile, cardiac biomarkers were normal.
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- 2018
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172. Clinical Characteristics, Management, and Outcomes of Acute Coronary Syndrome in Patients With Right Bundle Branch Block on Presentation.
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Chan, William K, Goodman, Shaun G, Brieger, David, Fox, Keith A A, Gale, Chris P, Chew, Derek P, Udell, Jacob A, Lopez-Sendon, Jose, Huynh, Thao, Yan, Raymond T, Singh, Sheldon M, Yan, Andrew T, and ACS I and GRACE Investigators
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TREATMENT of acute coronary syndrome , *BUNDLE-branch block , *COMPARATIVE studies , *ELECTROCARDIOGRAPHY , *RESEARCH methodology , *MEDICAL cooperation , *PROGNOSIS , *RESEARCH , *RESEARCH funding , *RISK assessment , *SURVIVAL , *DISEASE management , *EVALUATION research , *DISEASE incidence , *ACQUISITION of data , *ACUTE coronary syndrome , *HOSPITAL mortality , *ODDS ratio , *DISEASE complications , *DIAGNOSIS - Abstract
We examined the relations between right bundle branch block (RBBB) and clinical characteristics, management, and outcomes among a broad spectrum of patients with acute coronary syndrome (ACS). Admission electrocardiograms of patients enrolled in the Global Registry of Acute Coronary Events (GRACE) electrocardiogram substudy and the Canadian ACS Registry I were analyzed independently at a blinded core laboratory. We performed multivariable logistic regression analysis to assess the independent prognostic significance of admission RBBB on in-hospital and 6-month mortality. Of 11,830 eligible patients with ACS (mean age 65; 66% non-ST-elevation ACS), 5% had RBBB. RBBB on admission was associated with older age, male sex, more cardiovascular risk factors, worse Killip class, and higher GRACE risk score (all p <0.01). Patients with RBBB less frequently received in-hospital cardiac catheterization, coronary revascularization, or reperfusion therapy (all p <0.05). The RBBB group had higher unadjusted in-hospital (8.8% vs 3.8%, p <0.001) and 6-month mortality rates (15.1% vs 7.6%, p <0.001). After adjusting for established prognostic factors in the GRACE risk score, RBBB was a significant independent predictor of in-hospital death (odds ratio 1.45, 95% CI 1.02 to 2.07, p = 0.039), but not cumulative 6-month mortality (odds ratio 1.29, 95% CI 0.95 to 1.74, p = 0.098). There was no significant interaction between RBBB and the type of ACS for either in-hospital or 6-month mortality (both p >0.50). In conclusion, across a spectrum of ACS, RBBB was associated with preexisting cardiovascular disease, high-risk clinical features, fewer cardiac interventions, and worse unadjusted outcomes. After adjusting for components of the GRACE risk score, RBBB was a significant independent predictor of early mortality. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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173. Atrioesophageal Fistula: A Review.
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Mohanan Nair, Krishna Kumar, Danon, Asaf, Valaparambil, Ajitkumar, Koruth, Jacob S., and Singh, Sheldon M.
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CATHETER ablation , *MEDICAL care - Abstract
Catheter ablation of atrial ablation (AF) has become an important therapy in recent years. As with all evolving techniques, unexpected complication may occur. Atrioesophageal fistula is a very rare complication of AF catheter ablation. Described for the first time in two very experienced centers in 2004, this complication is the most dreadful and lethal among all the others related to AF catheter ablation. Its clinical presentation is extremely variable. Rapid diagnosis and surgical therapy may prevent death. This review article will summarize the risk factors, diagnosis, treatment and possible preventive strategies for this condition. [ABSTRACT FROM AUTHOR]
- Published
- 2015
174. MRI Accurately Visualizes RF Ablation Delivery Targeted to MRI-Defined Arrhythmia Substrates in the Left Ventricle.
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Krahn PRP, Escartin T, Singh SM, Barry J, Larsen M, Guo F, Pop M, and Wright GA
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- Animals, Swine, Catheter Ablation methods, Arrhythmias, Cardiac diagnostic imaging, Arrhythmias, Cardiac surgery, Surgery, Computer-Assisted methods, Myocardial Infarction diagnostic imaging, Myocardial Infarction surgery, Radiofrequency Ablation methods, Imaging, Three-Dimensional methods, Cicatrix diagnostic imaging, Heart Ventricles diagnostic imaging, Heart Ventricles surgery, Magnetic Resonance Imaging methods
- Abstract
Objective: Investigate the capacity of MRI to evaluate efficacy of radiofrequency (RF) ablations delivered to MRI-defined arrhythmogenic substrates., Methods: Baseline MRI was performed at 3 T including 3D LGE in a swine model of chronic myocardial infarct (N = 8). MRI-derived maps of scar and heterogeneous tissue channels (HTCs) were generated using ADAS 3D. Animals underwent electroanatomic mapping and ablation of the left ventricle in CARTO3, guided by MRI-derived scar maps. Post-ablation MRI (in vivo at 3 T in 5/8 animals; ex vivo at 1.5 T in 3/8) included 3D native T1-weighted IR-SPGR (TI = 700-800 ms) to visualize RF lesions. T1-derived RF lesions were compared against excised tissue. The locations of T1-derived RF lesions were compared against CARTO ablation tags, and segment-wise sensitivity and specificity of lesion detection were calculated within the AHA 17-segment model., Results: RF lesions were clearly visualized in HTCs, scar, and myocardium. Ablation patterns delivered in CARTO matched T1-derived RF lesion patterns with high sensitivity (88.9%) and specificity (94.7%), and were closely matched in registered MR-EP data sets, with a displacement of 5.4 ±3.8 mm (N = 152 ablation tags)., Conclusion: Integrating MRI into ablative procedures for RF lesion assessment is feasible. Patterns of RF lesions created using a standard 3D EAM system are accurately reflected by MRI visualization in healthy myocardium, scar, and HTCs comprising the MRI-defined arrhythmia substrate., Significance: MRI visualization of RF lesions can provide near-immediate ( 24 h) assessment of ablation, potentially indicating whether critical MRI-defined ventricular tachycardia substrates have been adequately ablated.
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- 2024
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175. "Spasms in Silence": A case of coronary vasospasm-induced ventricular fibrillation.
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Ranganathan D, Saad M, and Singh SM
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A 56-year-old man presented following an aborted cardiac arrest. His initial ECGs showed episodes of transient repolarization abnormalities. Coronary vasospasm can be a precipitant for ventricular arrhythmia in these patients, underpinning the importance of continuous ECG for accurate diagnosis and management., Competing Interests: Authors declare no conflict of interests for this article., (© 2024 The Author(s). Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society.)
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- 2024
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176. Volume-Outcome Relationship in Left Atrial Appendage Occlusion: It Is Not as Simple as It Sounds.
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Qeska D, Singh SM, and Wijeysundera HC
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- Humans, Treatment Outcome, Atrial Function, Left, Risk Factors, Stroke prevention & control, Stroke etiology, Atrial Appendage physiopathology, Atrial Fibrillation physiopathology, Atrial Fibrillation diagnosis, Atrial Fibrillation therapy, Atrial Fibrillation surgery, Cardiac Catheterization adverse effects
- Abstract
Competing Interests: Disclosures None.
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- 2024
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177. Ablation of ventricular tachycardia after septal myectomy for hypertrophic cardiomyopathy.
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Demirtas AO and Singh SM
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Electrocardiography and 3D mapping images of the case., Competing Interests: Authors declare no conflict of interests for this article., (© 2024 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society.)
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- 2024
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178. Physical Activity, Heart Rate Variability, and Ventricular Arrhythmia During the COVID-19 Lockdown: Retrospective Cohort Study.
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Texiwala SZ, de Souza RJ, Turner S, and Singh SM
- Abstract
Background: Ventricular arrhythmias (VAs) increase with stress and national disasters. Prior research has reported that VA did not increase during the onset of the COVID-19 lockdown in March 2020, and the mechanism for this is unknown., Objective: This study aimed to report the presence of VA and changes in 2 factors associated with VA (physical activity and heart rate variability [HRV]) at the onset of COVID-19 lockdown measures in Ontario, Canada., Methods: Patients with implantable cardioverter defibrillator (ICD) followed at a regional cardiac center in Ontario, Canada with data available for both HRV and physical activity between March 1 and 31, 2020, were included. HRV, physical activity, and the presence of VA were determined during the pre- (March 1-10, 2020) and immediate postlockdown (March 11-31) period. When available, these data were determined for the same period in 2019., Results: In total, 68 patients had complete data for 2020, and 40 patients had complete data for 2019. Three (7.5%) patients had VA in March 2019, whereas none had VA in March 2020 (P=.048). Physical activity was reduced during the postlockdown period (mean 2.3, SD 1.6 hours vs mean 2.1, SD 1.6 hours; P=.003). HRV was unchanged during the pre- and postlockdown period (mean 91, SD 30 ms vs mean 92, SD 28 ms; P=.84)., Conclusions: VA was infrequent during the COVID-19 pandemic. A reduction in physical activity with lockdown maneuvers may explain this observation., (©Sikander Z Texiwala, Russell J de Souza, Suzette Turner, Sheldon M Singh. Originally published in JMIR Cardio (https://cardio.jmir.org), 05.02.2024.)
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- 2024
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179. Stroke risk in women with atrial fibrillation.
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Buhari H, Fang J, Han L, Austin PC, Dorian P, Jackevicius CA, Yu AYX, Kapral MK, Singh SM, Tu K, Ko DT, Atzema CL, Benjamin EJ, Lee DS, and Abdel-Qadir H
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- Female, Humans, Male, Aged, Aged, 80 and over, Cohort Studies, Cholesterol, LDL, Proportional Hazards Models, Risk Factors, Risk Assessment, Atrial Fibrillation complications, Atrial Fibrillation epidemiology, Atrial Fibrillation diagnosis, Stroke etiology, Stroke complications
- Abstract
Background and Aims: Female sex is associated with higher rates of stroke in atrial fibrillation (AF) after adjustment for other CHA2DS2-VASc factors. This study aimed to describe sex differences in age and cardiovascular care to examine their relationship with stroke hazard in AF., Methods: Population-based cohort study using administrative datasets of people aged ≥66 years diagnosed with AF in Ontario between 2007 and 2019. Cause-specific hazard regression was used to estimate the adjusted hazard ratio (HR) for stroke associated with female sex over a 2-year follow-up. Model 1 included CHA2DS2-VASc factors, with age modelled as 66-74 vs. ≥ 75 years. Model 2 treated age as a continuous variable and included an age-sex interaction term. Model 3 further accounted for multimorbidity and markers of cardiovascular care., Results: The cohort consisted of 354 254 individuals with AF (median age 78 years, 49.2% female). Females were more likely to be diagnosed in emergency departments and less likely to receive cardiologist assessments, statins, or LDL-C testing, with higher LDL-C levels among females than males. In Model 1, the adjusted HR for stroke associated with female sex was 1.27 (95% confidence interval 1.21-1.32). Model 2 revealed a significant age-sex interaction, such that female sex was only associated with increased stroke hazard at age >70 years. Adjusting for markers of cardiovascular care and multimorbidity further decreased the HR, so that female sex was not associated with increased stroke hazard at age ≤80 years., Conclusion: Older age and inequities in cardiovascular care may partly explain higher stroke rates in females with AF., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2024
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180. Same-Day Discharge After Percutaneous Left Atrial Appendage Occlusion Procedures.
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Kagal ES, Bauer N, and Singh SM
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Information is evolving on the safety of same-day discharge (SDD) after left atrial appendage occlusion (LAAO) procedures. This single-centre retrospective study evaluated the feasibility of SDD and reported on the 30-day rehospitalization rate in patients discharged same-day compared with those admitted overnight after LAAO. Key findings of this study included more than 85% of patients with LAAO were safely discharged same-day; the rate of postdischarge rehospitalization was similar in SDD patients and those admitted overnight; and approximately 1 in 10 patients who had LAAO procedures were rehospitalized within 30 days postprocedure., (© 2023 The Authors.)
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- 2023
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181. P-Wave Duration/Amplitude Ratio Quantifies Atrial Low-Voltage Area and Predicts Atrial Arrhythmia Recurrence After Pulmonary Vein Isolation.
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Zhang ZR, Ragot D, Massin SZ, Suszko A, Ha ACT, Singh SM, and Chauhan VS
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- Humans, Heart Atria, Electrocardiography, ROC Curve, Recurrence, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Pulmonary Veins surgery, Catheter Ablation
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Background: Atrial low-voltage areas (LVAs) in patients with atrial fibrillation increase the risk of atrial arrhythmia (AA) recurrence after pulmonary vein isolation (PVI). Contemporary LVA prediction scores (DR-FLASH, APPLE) do not include P-wave metrics. We aimed to evaluate the utility of P-wave duration/amplitude ratio (PWR) in quantifying LVA and predicting AA recurrence after PVI., Methods: In 65 patients undergoing first-time PVI, 12-lead ECGs were recorded during sinus rhythm. PWR was calculated as the ratio between the longest P-wave duration and P-wave amplitude in lead I. High-resolution biatrial voltage maps were collected and LVAs included bipolar electrogram amplitudes < 0.5 mV or < 1.0 mV. An LVA quantification model was created with the use of clinical variables and PWR, and then validated in a separate cohort of 24 patients. Seventy-eight patients were followed for 12 months to evaluate AA recurrence., Results: PWR strongly correlated with left atrial (LA) (< 0.5 mV: r = 0.60; < 1.0 mV: r = 0.68; P < 0.001) and biatrial LVA (< 0.5 mV: r = 0.63; < 1.0 mV: r = 0.70; P < 0.001). Addition of PWR to clinical variables improved model quantification of LA LVA at the < 0.5 mV (adjusted R
2 = 0.59 to 0.68) and < 1.0 mV (adjusted R2 = 0.59 to 0.74) cutoffs. In the validation cohort, PWR model-predicted LVA correlated strongly with measured LVA (< 0.5 mV: r = 0.78; < 1.0 mV: r = 0.81; P < 0.001). PWR model was superior to DR-FLASH (area under the receiver operating characteristic curve [AUC] 0.90 vs 0.78; P = 0.030) and APPLE (AUC 0.90 vs 0.67; P = 0.003) at detecting LA LVA and similar at predicting AA recurrence after PVI (AUC 0.67 vs 0.65 and 0.60)., Conclusion: Our novel PWR model accurately quantifies LVA and predicts AA recurrence after PVI. PWR model-predicted LVA may help guide patient selection for PVI., (Copyright © 2023 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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182. Long-term Clinical Outcomes in Contemporary Patients Undergoing Left Atrial Appendage Occlusion Procedures in Ontario, Canada.
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Singh SM, Qui F, and Wijeysundera HC
- Abstract
Background: Percutaneous left atrial appendage occlusion (LAAO) is an alternative for stroke prevention in patients with atrial fibrillation with contraindications to oral anticoagulation. Population-level real-world data describing the use and outcomes of LAAO procedures are evolving, with a paucity of longer-term follow-up data. We report on the patient characteristics, procedure complications, and longer-term clinical outcomes in all patients undergoing LAAO procedures in Ontario, Canada., Methods: All patients undergoing LAAO procedure between April 1, 2013 and March 31, 2022 were identified. Linked administrative databases were utilized to determine patient clinical and procedural characteristics. Outcomes of interest included procedural complications at 7 and 30 days, and longer-term rates of stroke, bleeding, all-cause rehospitalization, and mortality., Results: A total of 549 individuals were included in the study cohort. The average age was 75 ± 8 years, with 66% being of male sex, with a mean CHA
2 DS2 VASc score of 4.4 ± 1.6, and with 68% not receiving oral anticoagulation. Follow-up for 2.6 ± 2.0 patient-years was available. Stroke occurred in 2.8% during the follow-up period (1.1 per 100 patient-years), bleeding in 10% (4.0 per 100 patient-years), and any hospital readmission in 63% (43 per 100 patient-years). A total of 29% of the cohort died during the follow-up period (11 per 100 patient-years), with 1.8% of the cohort dying during the procedural hospitalization. The mortality rate was unchanged during the study period ( P for trend = 0.72)., Conclusions: Long-term stroke and bleeding rates are low in patients undergoing LAAO procedures in Ontario, Canada. All-cause mortality in this population is high and remained unchanged during the study period., (© 2023 The Authors.)- Published
- 2023
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183. Statin Use and Stroke Rate in Older Adults With Atrial Fibrillation: A Population-Based Cohort Study.
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Shweikialrefaee B, Ko DT, Fang J, Pang A, Austin PC, Dorian P, Singh SM, Jackevicius CA, Tu K, Lee DS, and Abdel-Qadir H
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- Humans, Female, Aged, Male, Cohort Studies, Retrospective Studies, Risk Factors, Lipoproteins, LDL, Lipids, Ontario epidemiology, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Atrial Fibrillation drug therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Stroke epidemiology, Stroke etiology, Stroke prevention & control
- Abstract
Background Atherosclerotic disease is an important contributor to adverse outcomes in patients with atrial fibrillation (AF). There is limited recognition of the association between statin use and stroke rates in AF. We aimed to quantify the association between statin use and stroke rate in AF. Methods and Results Using linked administrative databases in Ontario, Canada, we conducted a population-based retrospective cohort study of patients, aged ≥66 years, diagnosed with AF between 2009 and 2019. We used cause-specific hazard regression to determine the association of statin use with stroke rate. We developed a second model to further adjust for lipid levels in the subset of patients with available measurements in the year before AF diagnosis. Both models adjusted for age, sex, heart failure, hypertension, diabetes, stroke/transient ischemic attack, vascular disease, and P2Y12 inhibitors at baseline, plus anticoagulation as a time-varying covariate. We studied 261 659 qualifying patients (median age, 78 years; 49% women). Statins were used in 142 834 (54.6%) patients, and 145 673 (55.7%) had lipid measurement(s) in the preceding year. Statin use was associated with lower stroke rates, with adjusted hazard ratios of 0.83 (95% CI, 0.77-0.88; P <0.001) in the full cohort and 0.87 (95% CI, 0.78-0.97; P =0.01) when adjusting for lipid data. Stroke rates increased in a near-linear manner as low-density lipoprotein values increased >1.5 mmol/L. Conclusions Statins were associated with lower stroke rates in patients with AF, whereas higher low-density lipoprotein levels were associated with higher stroke rates, highlighting the importance of vascular risk factor treatment in AF.
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- 2023
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184. Prognostic Value of Different Thresholds for Myocardial Scar Quantification on Cardiac MRI Late Gadolinium Enhancement Images in Patients Receiving Implantable Cardioverter Defibrillators.
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Shalmon T, Hamad FMD, Jimenez-Juan L, Kirpalani A, Urzua Fresno CM, Folador L, Tan NS, Singh SM, Ge Y, Dorian P, Lima JAC, Wong KCK, Deva DP, and Yan AT
- Abstract
Purpose: To compare the predictive value of different myocardial scar quantification thresholds using cardiac MRI for appropriate implantable cardioverter defibrillator (ICD) shock and mortality., Materials and Methods: In this retrospective, two-center observational cohort study, patients with ischemic or nonischemic cardiomyopathy underwent cardiac MRI prior to ICD implantation. Late gadolinium enhancement (LGE) was first determined visually and then quantified by blinded cardiac MRI readers using different SDs above the mean signal of normal myocardium, full-width half-maximum, and manual thresholding. The intermediate signal "gray zone" was calculated as the differences between different SDs., Results: Among 374 consecutive eligible patients (mean age, 61 years ± 13 [SD]; mean left ventricular ejection fraction, 32% ± 14; secondary prevention, 62.7%), those with LGE had a higher rate of appropriate ICD shock or death than those without (37.5% vs 26.6%, log-rank P = .04) over a median follow-up of 61 months. In multivariable analysis, none of the thresholds for quantifying scar was a significant predictor of mortality or appropriate ICD shock, while the extent of gray zone was an independent predictor (adjusted hazard ratio per 1 g = 1.025; 95% CI: 1.008, 1.043; P = .005) regardless of the presence or absence of ischemic heart disease ( P interaction = .57). Model discrimination was highest for the model incorporating the gray zone (between 2 SD and 4 SD)., Conclusion: Presence of LGE was associated with a higher rate of appropriate ICD shock or death. Although none of the scar quantification techniques predicted outcomes, the gray zone both in infarct and nonischemic scar was an independent predictor and may refine risk stratification. Keywords: MRI, Scar Quantification, Implantable Cardioverter Defibrillator, Sudden Cardiac Death Supplemental material is available for this article. © RSNA, 2023., Competing Interests: Disclosures of conflicts of interest: T.S. No relevant relationships. F.M.D.H. No relevant relationships. L.J.J. No relevant relationships. A.K. No relevant relationships. C.M.U.F. No relevant relationships. L.F. No relevant relationships. N.S.T. No relevant relationships. S.M.S. No relevant relationships. Y.G. No relevant relationships. P.D. No relevant relationships. J.A.C.L. No relevant relationships. K.C.K.W. No relevant relationships. D.P.D. No relevant relationships. A.T.Y. No relevant relationships., (© 2023 by the Radiological Society of North America, Inc.)
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- 2023
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185. Variation and clinical consequences of wait-times for atrial fibrillation ablation: population level study in Ontario, Canada.
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Qeska D, Singh SM, Qiu F, Manoragavan R, Cheung CC, Ko DT, Sud M, Terricabras M, and Wijeysundera HC
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- Adult, Humans, Waiting Lists, Ontario epidemiology, Treatment Outcome, Recurrence, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Atrial Fibrillation drug therapy, Heart Failure etiology, Catheter Ablation methods
- Abstract
Aims: Atrial fibrillation (AF) is the most common cardiac rhythm disorder. Emerging evidence supporting the efficacy of catheter ablation in managing AF has led to increased demand for this therapy, potentially outpacing the capacity to perform this procedure. Mismatch between demand and capacity for AF ablation results in wait-times which have not been comprehensively evaluated at a population level. Additionally, the consequences of such delays in AF ablation, namely the risk of hospitalization or adverse events, have not been studied., Methods and Results: This observational cohort study included adults referred for catheter ablation to treat AF in Ontario, Canada, between 1 April 2016 and 31 March 2020. Wait-time was defined from referral to the earliest of ablation, death, off-list, or the study endpoint of 31 March 2022. The outcomes of interest included a composite of death, hospitalization for AF/heart failure, and emergency department visit for AF/heart failure. Our study cohort included 6253 patients referred for de novo AF ablation. The median wait-time for patients who received and who did not receive ablation was 218 days (IQR: 112-363) and 520 days (IQR: 270-763), respectively. Wait-time increased consistently for patients referred between October 2017 and March 2020. Mortality was rare, but significant morbidity was observed, affecting 19.2% of patients on the waitlist for AF ablation. Paroxysmal AF was associated with a statistically significant greater risk for adverse outcomes on the waitlist (HR 1.51, 95% CI 1.18-1.93)., Conclusion: Wait-times for AF ablation are increasing and are associated with significant morbidity., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2023
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186. Standard vs Augmented Ablation of Paroxysmal Atrial Fibrillation for Reduction of Atrial Fibrillation Recurrence: The AWARE Randomized Clinical Trial.
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Nair GM, Birnie DH, Nery PB, Redpath CJ, Sarrazin JF, Roux JF, Parkash R, Bernier M, Sterns LD, Sapp J, Novak P, Veenhuyzen G, Morillo CA, Singh SM, Sadek MM, Golian M, Klein A, Sturmer M, Chauhan VS, Angaran P, Green MS, Bernick J, Wells GA, and Essebag V
- Subjects
- Humans, Female, Middle Aged, Male, Prospective Studies, Electrocardiography, Ambulatory, Atrial Fibrillation drug therapy, Atrial Flutter, Pulmonary Veins surgery, Catheter Ablation adverse effects
- Abstract
Importance: Recurrent atrial fibrillation (AF) commonly occurs after catheter ablation and is associated with patient morbidity and health care costs., Objective: To evaluate the superiority of an augmented double wide-area circumferential ablation (WACA) compared with a standard single WACA in preventing recurrent atrial arrhythmias (AA) (atrial tachycardia, atrial flutter, or atrial fibrillation [AF]) in patients with paroxysmal AF., Design, Setting, and Participants: This was a pragmatic, multicenter, prospective, randomized, open, blinded end point superiority clinical trial conducted at 10 university-affiliated centers in Canada. The trial enrolled patients 18 years and older with symptomatic paroxysmal AF from March 2015 to May 2017. Analysis took place between January and April 2022. Analyses were intention to treat., Interventions: Patients were randomized (1:1) to receive radiofrequency catheter ablation for pulmonary vein isolation with either a standard single WACA or an augmented double WACA., Main Outcomes and Measures: The primary outcome was AA recurrence between 91 and 365 days postablation. Patients underwent 42 days of ambulatory electrocardiography monitoring after ablation. Secondary outcomes included need for repeated catheter ablation and procedural and safety variables., Results: Of 398 patients, 195 were randomized to the single WACA (control) arm (mean [SD] age, 60.6 [9.3] years; 65 [33.3%] female) and 203 to the double WACA (experimental) arm (mean [SD] age, 61.5 [9.3] years; 66 [32.5%] female). Overall, 52 patients (26.7%) in the single WACA arm and 50 patients (24.6%) in the double WACA arm had recurrent AA at 1 year (relative risk, 0.92; 95% CI, 0.66-1.29; P = .64). Twenty patients (10.3%) in the single WACA arm and 15 patients (7.4%) in the double WACA arm underwent repeated catheter ablation (relative risk, 0.72; 95% CI, 0.38-1.36). Adjudicated serious adverse events occurred in 13 patients (6.7%) in the single WACA arm and 14 patients (6.9%) in the double WACA arm., Conclusions and Relevance: In this randomized clinical trial of patients with paroxysmal AF, additional ablation by performing a double ablation lesion set did not result in improved freedom from recurrent AA compared with a standard single ablation set., Trial Registration: ClinicalTrials.gov Identifier: NCT02150902.
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- 2023
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187. Association Between Concurrent Use of Amiodarone and DOACs and Risk of Bleeding in Patients With Atrial Fibrillation.
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Shurrab M, Jackevicius CA, Austin PC, Tu K, Qiu F, Singh SM, Crystal E, Caswell J, Michael F, Andrade JG, and Ko DT
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- Adult, Humans, Female, Aged, 80 and over, Male, Case-Control Studies, Administration, Oral, Anticoagulants adverse effects, Hemorrhage chemically induced, Hemorrhage epidemiology, Ontario epidemiology, Atrial Fibrillation complications, Atrial Fibrillation drug therapy, Atrial Fibrillation epidemiology, Amiodarone adverse effects, Stroke epidemiology
- Abstract
Amiodarone is a commonly used pharmacotherapy in patients with atrial fibrillation (AF), with a potential for drug-drug interactions with direct oral anticoagulants (DOACs). We aimed to assess the bleeding risk after co-prescription of amiodarone and DOACs among adults with AF. We conducted a population-based, nested case-control study in Ontario, Canada. The study population included all patients with AF aged >66 years on a DOAC between April 1, 2011 and March 31, 2018. Cases were patients admitted with major bleeding (index date). Controls were matched in a 2:1 ratio to cases. We categorized exposure to amiodarone before the index date as: (1) current users (amiodarone within 60 days), (2) past users (amiodarone within 61 to 140 days), and (3) unexposed (no amiodarone prescription or amiodarone prescription >140 days before index date). Conditional logistic regression models were used to examine the association between bleeding and amiodarone co-prescription. Among 86,679 patients with AF on a DOAC, we identified 2,766 cases (3.2%) admitted with major bleeding. The median age of patients with AF was 80 years (interquartile range 75 to 85); 48.3% were women. After multivariable adjustment, there was a significant association between major bleeding and current use of amiodarone (adjusted odds ratio 1.53; 95% confidence interval 1.24 to 1.89, p <0.001) but no significant association between major bleeding and past use of amiodarone (adjusted odds ratio 1.13, 95% confidence interval 0.76 to 1.68, p = 0.545) compared with the unexposed group. In conclusion, among older patients with AF on a DOAC, there was 53% increased odds of major bleeding with the current use of amiodarone., (Copyright © 2022 Elsevier Inc. All rights reserved.)
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- 2023
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188. Use of Sacubitril/Valsartan Prior to Primary Prevention Implantable Cardioverter Defibrillator Implantation.
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Ozier D, Rafiq T, de Souza RJ, and Singh SM
- Abstract
Background: Implantable cardioverter defibrillators (ICDs) are an adjunct to guideline-directed medical therapy for heart failure with reduced ejection fraction. The uptake of sacubitril/valsartan in this population is not well described. We report the uptake and factors associated with sacubitril/valsartan use in patients with left ventricular dysfunction undergoing ICD implantation., Methods: A retrospective chart review was performed on all patients with left ventricular dysfunction who underwent de novo primary prevention ICD implantation between October 2015 and December 2021 (n = 422) at Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Pre-procedure sacubitril/valsartan use was determined. Logistic regression analysis was performed to examine factors associated with sacubitril/valsartan use. A Bayesian estimator of abrupt change was employed to determine a time period in which a change in the rate of sacubitril/valsartan use occurred., Results: Loop diuretic use (odds ratio [OR] = 2.20) and higher severity of New York Heart Association class symptoms (OR = 1.62) were associated with sacubitril/valsartan use. Sacubitril/valsartan use increased during the study period, to 59% in December 2021. This increase was larger among those aged ≥ 65 years (OR = 1.09). A change in the rate of sacubitril/valsartan use occurred 3 years after drug approval, 1 year after provincial drug coverage became available, and 6 months after being strongly recommended in clinical guidelines., Conclusions: In a contemporary cohort of ICD patients, sacubitril/valsartan use increased between 2015 and 2021, notably in those aged ≥ 65 years and after government drug coverage became available. Understanding barriers to sacubitril/valsartan use in ICD patients is recommended to improve clinical outcomes and survival in this population., (© 2022 The Authors.)
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- 2022
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189. Syncope After Transcatheter Tricuspid Valve Replacement.
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Mumtaz M, Demirtas AO, Ozier D, and Singh SM
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- Cardiac Catheterization adverse effects, Humans, Syncope diagnosis, Syncope etiology, Treatment Outcome, Tricuspid Valve diagnostic imaging, Tricuspid Valve surgery, Heart Valve Prosthesis Implantation adverse effects, Tricuspid Valve Insufficiency diagnostic imaging, Tricuspid Valve Insufficiency etiology, Tricuspid Valve Insufficiency surgery
- Abstract
Competing Interests: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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- 2022
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190. Skin burn after magnetic resonance imaging in a patient with an implantable cardioverter-defibrillator.
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Turner S and Singh SM
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- 2022
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191. A local activation time histogram-An invaluable tool to diagnose a rare and complex atrial flutter mechanism.
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Demirtas AO, Sanhueza E, and Singh SM
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- 2022
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192. What Is the Mechanism of This Cardiac Rhythm?
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Kumar SK and Singh SM
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- Heart Rate, Humans, Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest
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- 2022
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193. Multilevel Conduction Abnormalities: Hickam's Dictum or Occam's Razor?
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Kumar SK and Singh SM
- Abstract
A 62-year-old woman with a spinal cord injury and no prior cardiac disease presented with an abnormal electrocardiogram. A systematic evaluation of the electrocardiogram suggested a diagnosis of concealed His extrasystole. This case report features an interesting phenomenon of pseudo-atrioventricular block due to concealed junctional discharges., Competing Interests: The authors report no conflicts of interest for the published content. No funding information was provided., (Copyright: © 2022 Innovations in Cardiac Rhythm Management.)
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- 2022
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194. Augmented wide area circumferential catheter ablation for reduction of atrial fibrillation recurrence (AWARE) trial: Design and rationale.
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Nair GM, Birnie DH, Wells GA, Nery PB, Redpath CJ, Sarrazin JF, Roux JF, Parkash R, Bernier M, Sterns LD, Novak P, Veenhuyzen G, Morillo CA, Singh SM, Sturmer M, Chauhan VS, Angaran P, and Essebag V
- Subjects
- Canada, Humans, Prospective Studies, Quality of Life, Recurrence, Treatment Outcome, Atrial Fibrillation, Catheter Ablation methods, Pulmonary Veins surgery
- Abstract
Background: Recurrence of atrial fibrillation (AF) after a pulmonary vein isolation procedure is often due to electrical reconnection of the pulmonary veins. Repeat ablation procedures may improve freedom from AF but are associated with increased risks and health care costs. A novel ablation strategy in which patients receive "augmented" ablation lesions has the potential to reduce the risk of AF recurrence., Objective: The Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence (AWARE) Trial was designed to evaluate whether an augmented wide-area circumferential antral (WACA) ablation strategy will result in fewer atrial arrhythmia recurrences in patients with symptomatic paroxysmal AF, compared with a conventional WACA strategy., Methods/design: The AWARE trial was a multicenter, prospective, randomized, open, blinded endpoint trial that has completed recruitment (ClinicalTrials.gov NCT02150902). Patients were randomly assigned (1:1) to either the control arm (single WACAlesion set) or the interventional arm (augmented- double WACA lesion set performed after the initial WACA). The primary outcome was atrial tachyarrhythmia (AA; atrial tachycardia [AT], atrial flutter [AFl] or AF) recurrence between days 91 and 365 post catheter ablation. Patient follow-up included 14-day continuous ambulatory ECG monitoring at 3, 6, and 12 months after catheter ablation. Three questionnaires were administered during the trial- the EuroQuol-5D (EQ-5D) quality of life scale, the Canadian Cardiovascular Society Severity of Atrial Fibrillation scale, and a patient satisfaction scale., Discussion: The AWARE trial was designed to evaluate whether a novel approach to catheter ablation reduced the risk of AA recurrence in patients with symptomatic paroxysmal AF., Competing Interests: Conflicts of interest Dr Girish M. Nair reports honoraria, speaking fees and grant support from Biosense Webster Inc and Boston Scientific Inc related to Atrial Fibrillation (Modest). Dr Pablo B. Nery reports honoraria, speaking fees and grant support from Biosense Webster Canada, not related to this work (Modest). Dr David H. Birnie reports grants from Boehringer Ingelheim, Germany, grants from Pfizer and Bristol-Myers Squibb, New York (Modest). Dr George Veenhuyzen has received honoraria & consulting fees from Medtronic, BMS-Pfizer, Servier, & Biotronik. Dr Jean-Francois Sarrazin has received consulting fees from Biosense Webster. Dr Jean-Francois Roux has received consulting feeds from Biosense Webster. Dr Carlos A. Morillo has received honoraria/consulting fees from Abbott, Biosense Webster, Boston Scientific, and Medtronic for AF related lectures and research support. Dr Ratika Parkash has received consulting fees/honoraria and research support from Abbott, Biosense Webster and Medtronic Inc Dr Vijay S. Chauhan has received consulting fees/honoraria and research support from Biosense Webster Inc Dr Vidal Essebag has received honoraria from Abbott, Biosense Webster, Boston Scientific, and Medtronic. The other authors have no disclosures related to this publication., (Copyright © 2022 Elsevier Inc. All rights reserved.)
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- 2022
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195. Arrhythmia diagnosis using a permanent pacemaker.
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Demirtas AO, Sanhueza E, Terricabras M, and Singh SM
- Abstract
Competing Interests: N/A
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- 2022
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196. Long-term mortality of academy award winning actors and actresses.
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Redelmeier DA and Singh SM
- Subjects
- Cohort Studies, Humans, Longevity, Motion Pictures, Awards and Prizes, Life Expectancy
- Abstract
Background: Social status gradients are powerful health determinants for individuals living in poverty. We tested whether winning an Academy award (Oscar) for acting was associated with long-term survival., Methods: We conducted a longitudinal cohort analysis of all actors and actresses nominated for an Academy award in a leading or a supporting role. For each, a control was identified based on age, sex, and co-staring in the same film., Results: Overall, 2,111 individuals were analyzed with 1,122 total deaths occurring during a median follow-up of 68.8 years. Comparisons of winners to controls yielded a 4.8% relative difference average life-span (95% confidence interval: 1.6 to 7.9, p = 0.004), a 5.1 year absolute increase in life expectancy (95% confidence interval: 3.0 to 7.2, p < 0.001), and a 41% improvement in mortality hazard (95% confidence interval: 19 to 68, p < 0.001). The increased survival tended to be greater in recent years, for individuals winning at a younger age, and among those with multiple wins. The increased survival replicated in secondary analyses comparing winners to nominees and was not observed in analyses comparing nominees to controls., Conclusions: Academy award winning actors and actresses show a positive association between success and survival, suggesting the importance of behavioral, psychological, or other modifiable health factors unrelated to poverty., Competing Interests: The authors have declared that no competing interests exist.
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- 2022
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197. Association of Diabetes Duration and Glycemic Control With Stroke Rate in Patients With Atrial Fibrillation and Diabetes: A Population-Based Cohort Study.
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Abdel-Qadir H, Gunn M, Lega IC, Pang A, Austin PC, Singh SM, Jackevicius CA, Tu K, Dorian P, Lee DS, and Ko DT
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- Aged, Cohort Studies, Glycated Hemoglobin analysis, Glycemic Control, Humans, Risk Assessment, Risk Factors, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Diabetes Mellitus diagnosis, Diabetes Mellitus epidemiology, Stroke complications, Stroke epidemiology, Stroke prevention & control
- Abstract
Background There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). Our objective was to study the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke in people with diabetes and newly diagnosed AF. Methods and Results This was a population-based cohort study using linked administrative data sets. We studied 37 209 individuals aged ≥66 years diagnosed with AF in Ontario between April 2009 and March 2019, who had diabetes diagnosed 1 to 16 years beforehand. The primary outcome was hospitalization for stroke at 1 year. Cause-specific hazard regression was used to model the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke. Restricted cubic spline analyses showed increasing hazard ratios (HR) for stroke with longer diabetes duration that plateaued after 10 years and increasing HRs for stroke with HbA1c levels >7%. Relative to patients with <5 years diabetes duration, stroke rates were significantly higher for patients with ≥10 years duration (HR, 1.45; 95% CI, 1.16-1.82; P =0.001), while diabetes duration 5 to <10 years was not significantly different. Relative to glycated hemoglobin 6% to <7%, values ≥8% were associated with higher stroke rates (HR, 1.44; 95% CI, 1.12-1.84; P =0.004), while other HbA1c categories were not significantly different. Conclusions Longer diabetes duration and higher glycated hemoglobin were associated with significantly higher stroke rates in patients with AF and diabetes. Models for stroke risk prediction and preventive care in AF may be improved by considering patients' diabetes characteristics.
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- 2022
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198. Left atrial volume and function measured by cardiac magnetic resonance imaging as predictors of shocks and mortality in patients with implantable cardioverter-defibrillators.
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Gong IY, Yazdan-Ashoori P, Jimenez-Juan L, Tan NS, Angaran P, Chacko BR, Al-Mousawy S, Singh SM, Shalmon T, Folador L, Mangat I, Deva DP, and Yan AT
- Subjects
- Death, Sudden, Cardiac, Heart Atria diagnostic imaging, Humans, Magnetic Resonance Imaging, Predictive Value of Tests, Retrospective Studies, Risk Factors, Defibrillators, Implantable
- Abstract
Left atrial (LA) volume and function (LA ejection fraction, LAEF) have demonstrated prognostic value in various cardiovascular diseases. We investigated the incremental value of LA volume and LAEF as measured by cardiovascular magnetic resonance imaging (CMR) for prediction of appropriate implantable cardioverter defibrillator (ICD) shock or all-cause mortality, in patients with ICD. We conducted a retrospective, multi-centre observational cohort study of patients who underwent CMR prior to primary or secondary prevention ICD implantation. A single, blinded reader measured maximum LA volume index (maxLAVi), minimum LA volume index (minLAVi), and LAEF. The primary outcome was a composite of independently adjudicated appropriate ICD shock or all-cause death. A total of 392 patients were enrolled. During a median follow-up time of 61 months, 140 (35.7%) experienced an appropriate ICD shock or died. Higher maxLAVi and minLAVi, and lower LAEF were associated with greater risk of appropriate ICD shock or death in univariate analysis. However, in multivariable analysis, LAEF (HR 0.92 per 10% higher, 95% CI 0.81-1.04, p = 0.17) and maxLAVi (HR 1.02 per 10 ml/m
2 higher, 95% CI 0.93-1.12, p = 0.72) were not independent predictors of the primary outcome. In conclusion, LA volume and function measured by CMR were univariate but not independent predictors of appropriate ICD shocks or mortality. These findings do not support the routine assessment of LA volume and function to refine risk stratification to guide ICD implant. Larger studies with longer follow-up are required to further delineate the clinical implications of LA size and function., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.)- Published
- 2021
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199. The Natural History and Treatment of Cardiac Implantable Electronic Device Associated Pneumothorax-A 10-Year Single-Centre Experience.
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Thomas GR, Kumar SK, Turner S, Moussa F, and Singh SM
- Abstract
Background: Pneumothorax is a common complication of cardiac implantable electronic device (CIED) procedures. There is a paucity of data on the natural history and management of a CIED-associated pneumothorax., Methods: This is a single-centre retrospective study of all consecutive patients with a CIED-associated pneumothorax between March 2010 and March 2020. Pneumothorax size was determined on all chest x-rays after device implantation and before chest tube insertion (if placed). Changes in pneumothorax size on serial chest x-rays were reported. Clinical outcomes in patients with a severe-sized pneumothorax treated with a chest tube were compared with those treated conservatively., Results: A total of 86 CIED-associated pneumothoraxes were identified, with 55 (63.9%) patients having a pneumothorax severe in size. Thirty-seven patients with a severe pneumothorax received a chest tube, whereas 18 were managed conservatively. Chest tube use was associated with a higher rate of admission to hospital (100% vs 63%, P = 0.02) for patients undergoing outpatient procedure, longer length of stay (6.3 ± 3.9 vs 2.7 ± 2.9 days, P = 0.04), but fewer chest x-rays (1.9 ± 0.7 vs 4.1 ± 2.5, P = 0.002)., Conclusion: An initial strategy of conservative management of a CIED-associated pneumothorax in select patients may be feasible and safe., (© 2020 Canadian Cardiovascular Society. Published by Elsevier Inc.)
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- 2020
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200. The management of cardiac implantable electronic device lead perforations: a multicentre study.
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Rav Acha M, Rafael A, Keaney JJ, Elitzur Y, Danon A, Shauer A, Taha L, Shechter Y, Bogot NR, Luria D, Ilan M, Singh SM, Mela T, Weisz G, Glikson M, and Medina A
- Subjects
- Aged, Cardiac Tamponade etiology, Cardiac Tamponade therapy, Device Removal, Female, Humans, Male, Pericardial Effusion etiology, Pericardial Effusion therapy, Pericardiocentesis, Prosthesis-Related Infections etiology, Prosthesis-Related Infections therapy, Retreatment, Retrospective Studies, Cardiac Resynchronization Therapy Devices adverse effects, Heart Injuries etiology, Heart Injuries therapy
- Abstract
Aims: Lead perforation is a rare, well-known complication of cardiac implantable electronic device (CIED) implants, whose management is mostly not evidence-based. Main management strategies include conservative approach based on clinical and lead function follow-up vs. routine invasive lead revision approach. This study compared the complications of both strategies by composite endpoint, including recurrent perforation-related symptoms, recurrent pericardial effusion (PEf), lead dysfunction, and device infection during 12 month follow-up., Methods and Results: Multicentre retrospective analysis, inquiring data from imaging studies, device interrogation, pericardiocentesis, and clinical charts of patients with suspected perforating leads between 2007 and 2014 in five hospitals. All cases were reviewed by electrophysiologist and defined as definite perforations by suggestive symptoms along with lead perforation on imaging, bloody PEf on pericardiocentesis shortly after implant, or right ventricular (RV) lead non-capture along with diaphragmatic stimulation upon bipolar pacing. Clinical outcomes associated with both management approaches were compared, with respect to the composite endpoint. The study included 48 definitive perforation cases: 22 managed conservatively and 26 via lead revision. Conservative management was associated with an increased composite endpoint compared with lead revision (8/22 vs. 1/26; P = 0.007). The dominant complication among the conservative cohort was appearance of cardiac tamponade during follow-up; 5/6 occurring in cases which presented with no or only mild PEf and were treated by antiplatelets/coagulants during or shortly after CIED implantation., Conclusion: A conservative management of CIED lead perforation is associated with increased complications compared with early lead revision. Lead revision may be the preferred management particularly in patients receiving antiplatelets/coagulants., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2019
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