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1,130 results on '"Slama, Rémy"'

151. Prenatal exposure to triclosan assessed through repeated urine samples and placental DNA methylation in the SEPAGES cohort

Author

Jedynak, Paulina, primary, Broséus, Lucile, additional, Tost, Jörg, additional, Busato, Florence, additional, Gabet, Stephan, additional, Thomsen, Cathrine, additional, Sakhi, Amrit K., additional, Pin, Isabelle, additional, Slama, Rémy, additional, Lepeule, Johanna, additional, Philippat, Claire, additional, and Study group, SEPAGES, additional

Published
2022
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156. InterMob: A 24-month randomised controlled trial comparing the effectiveness of an intervention including behavioural change techniques and free transport versus an intervention including air pollution awareness-raising on car use reduction among regular car users living in Grenoble, France

Author

Teran-Escobar, Claudia, primary, Duché, Sarah, additional, Bouscasse, Hélène, additional, Isoard-Gatheur, Sandrine, additional, Juen, Patrick, additional, Lacoste, Lilas, additional, Lyon-Caen, Sarah, additional, Mathy, Sandrine, additional, Ployon, Estelle, additional, Risch, Anna, additional, Sarrazin, Philippe, additional, Slama, Rémy, additional, Tabaka, Kamila, additional, Treibich, Carole, additional, Chardonnel, Sonia, additional, and Chalabaev, Aïna, additional

Published
2022
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159. Pollution de l’air : diviser par trois la mortalité tout en étant économiquement rentable, c’est possible !

Author

Mathy, Sandrine, Bouscasse, Hélène, Slama, Rémy, Gabet, Stephan, Laboratoire d'Economie Appliquée de Grenoble (GAEL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Université de Lille, Projets de recherche QAMECS et MobilAir financés par l'ADEME et par le programme IDEX de l'Université Grenoble Alpes dans le cadre du Programme Investissements d'Avenir de l'Agence nationale de la Recherche (ANR-15-IDEX-02)., ANR-15-IDEX-0002,UGA,IDEX UGA(2015), Mathy, Sandrine, and IDEX UGA - - UGA2015 - ANR-15-IDEX-0002 - IDEX - VALID

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDE.ES] Environmental Sciences/Environmental and Society, [SHS] Humanities and Social Sciences, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [SDE.ES]Environmental Sciences/Environmental and Society, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2022

167. Effects of F0 maternal diesel engine exhaust exposure during gestation on F1 and F2 offspring phenotype

Author

Couturier-Tarrade, Anne, Rousseau-Ralliard, Delphine, Valentino, Sarah A., Richard, Christophe, Hoarau, Pauline, Aioun, Josiane, Aubrière, Marie-Christine, Dahirel, Michèle, Lallemand, Marie Sylvie, Jouneau, Luc, Archilla, Catherine, Duranthon, Véronique, Morillon, Lucie, Guinot, Marine, Fournier, Natalie, Morin, Gwendoline, Mourier, Eve, Camous, Sylvaine, Fokkens, Paul H., Boere, John A., Slama, Rémy, Cassee, Flemming R., Chavatte-Palmer, Pascale, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), École nationale vétérinaire - Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Sciences de l'Animal et de l'Aliment de Jouy (SAAJ), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), and Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2022

168. Additional file 1 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Author

Broséus, Lucile, Vaiman, Daniel, Tost, Jörg, Martin, Camino Ruano San, Jacobi, Milan, Schwartz, Joel D., Béranger, Rémi, Slama, Rémy, Heude, Barbara, and Lepeule, Johanna

Abstract

Additional file 1: Supplementary methods and figures S1-S7. S1 - Workflow of DNA methylation data pre-processing; S2 - Overview of blood pressure data; S3 - Reference placental cell-type composition observed in the EDEN cohort; S4 - Pearson correlation between DMR effect sizes; S5.A - Sensitivity analyses for DMRs found in our main analysis; S5.B - Sensitivity analysis excluding preeclampsia cases for the DMRs found in our main analysis; S6.A - Magnitude and 95% confidence intervals of the association between each BP indicator and each reference cell-type; Figure S6.B - Compositional Principal Component Analysis performed on cell-type mixtures; S7.A - Diagnostic of the direct and indirect effect (mediated by cell-type composition) of BP on the methylation level of DMRs; S7.B - Total, direct and indirect effect of BP on the methylation level of DMRs.

Published
2022
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169. Additional file 1 of InterMob: a 24-month randomised controlled trial comparing the effectiveness of an intervention including behavioural change techniques and free transport versus an intervention including air pollution awareness-raising on car use reduction among regular car users living in Grenoble, France

Author

Teran-Escobar, Claudia, Duché, Sarah, Bouscasse, Hélène, Isoard-Gatheur, Sandrine, Juen, Patrick, Lacoste, Lilas, Lyon-Caen, Sarah, Mathy, Sandrine, Ployon, Estelle, Risch, Anna, Sarrazin, Philippe, Slama, Rémy, Tabaka, Kamila, Treibich, Carole, Chardonnel, Sonia, and Chalabaev, Aïna

Abstract

Additional file 1.

Published
2022
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171. Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer

Author

Smarr, Melissa M., Sapra, Katherine J., Gemmill, Alison, Kahn, Linda G., Wise, Lauren A., Lynch, Courtney D., Factor-Litvak, Pam, Mumford, Sunni L., Skakkebaek, Niels E., Slama, Rémy, Lobdell, Danelle T., Stanford, Joseph B., Jensen, Tina Kold, Boyle, Elizabeth Heger, Eisenberg, Michael L., Turek, Paul J., Sundaram, Rajeshwari, Thoma, Marie E., and Buck Louis, Germaine M.

Published
2017
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172. The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Author

Giorgis-Allemand, Lise, Pedersen, Marie, Bernard, Claire, Aguilera, Inmaculada, Beelen, Rob M. J., Chatzi, Leda, Cirach, Marta, Danileviciute, Asta, Dedele, Audrius, van Eijsden, Manon, Estarlich, Marisa, Fernández-Somoano, Ana, Fernández, Mariana F., Forastiere, Francesco, Gehring, Ulrike, Grazuleviciene, Regina, Gruzieva, Olena, Heude, Barbara, Hoek, Gerard, de Hoogh, Kees, van den Hooven, Edith H., Håberg, Siri E., Iñiguez, Carmen, Jaddoe, Vincent W. V., Korek, Michal, Lertxundi, Aitana, Lepeule, Johanna, Nafstad, Per, Nystad, Wenche, Patelarou, Evridiki, Porta, Daniela, Postma, Dirkje, Raaschou-Nielsen, Ole, Rudnai, Peter, Siroux, Valérie, Sunyer, Jordi, Stephanou, Euripides, Sørensen, Mette, Eriksen, Kirsten Thorup, Tuffnell, Derek, Varró, Mihály J., Vrijkotte, Tanja G. M., Wijga, Alet, Wright, John, Nieuwenhuijsen, Mark J., Pershagen, Göran, Brunekreef, Bert, Kogevinas, Manolis, and Slama, Rémy

Published
2017
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175. Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach.

Author

Hough, Ian, Rolland, Matthieu, Guilbert, Ariane, Seyve, Emie, Heude, Barbara, Slama, Rémy, Lyon-Caen, Sarah, Pin, Isabelle, Chevrier, Cécile, Kloog, Itai, and Lepeule, Johanna

Subjects
PREMATURE labor, WEATHER hazards, TEMPERATE climate, TEMPERATURE, HEALTH policy, HEAT waves (Meteorology)
Abstract

Background Ambient temperature, particularly heat, is increasingly acknowledged as a trigger for preterm delivery but study designs have been limited and results mixed. We aimed to comprehensively evaluate the association between ambient temperature throughout pregnancy and preterm delivery. Methods We estimated daily temperature throughout pregnancy using a cutting-edge spatiotemporal model for 5347 live singleton births from three prospective cohorts in France, 2002–2018. We performed Cox regression (survival analysis) with distributed lags to evaluate time-varying associations with preterm birth simultaneously controlling for exposure during the first 26 weeks and last 30 days of pregnancy. We examined weekly mean, daytime, night-time and variability of temperature, and heatwaves accounting for adaptation to location and season. Results Preterm birth risk was higher following cold (5th vs 50th percentile of mean temperature) 7–9 weeks after conception [relative risk (RR): 1.3, 95% CI: 1.0–1.6 for 2°C vs 11.6°C] and 10–4 days before delivery (RR: 1.6, 95% CI: 1.1–2.1 for 1.2°C vs 12.1°C). Night-time heat (95th vs 50th percentile of minimum temperature; 15.7°C vs 7.4°C) increased risk when exposure occurred within 5 weeks of conception (RR: 2.0, 95% CI: 1.05–3.8) or 20–26 weeks after conception (RR: 2.9, 95% CI: 1.2–6.8). Overall and daytime heat (high mean and maximum temperature) showed consistent effects. We found no clear associations with temperature variability or heatwave indicators, suggesting they may be less relevant for preterm birth. Conclusions In a temperate climate, night-time heat and chronic and acute cold exposures were associated with increased risk of preterm birth. These results suggest night-time heat as a relevant indicator. In the context of rising temperatures and more frequent weather hazards, these results should inform public health policies to reduce the growing burden of preterm births. [ABSTRACT FROM AUTHOR]

Published
2023
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179. Priorities for research on environment, climate and health, a European perspective

Author

Drakvik, Elina, Kogevinas, Manolis, Bergman, Åke, Devouge, Anais, Barouki, Robert, Devouge, Anaïs, Sarigiannis, Denis, Destoumieux-Garzón, Delphine, Matthies-Wiesler, Franziska, Peters, Annette, Zalko, Daniel, Villanueva, Cristina, Tonne, Cathryn, Cardis, Elisabeth, Diago-Navarro, Elizabeth, Antó, Josep M., Foraster, Maria, Nieuwenhuijsen, Mark, Straif, Kurt, van Veldhoven, Karin, Belesova, Kristine, Pearce, Neil, Haines, Andy, Klánová, Jana, Šebková, Kateřina, Pokorný, Lukáš, Hilscherová, Klára, Boekhold, Sandra, Staatsen, Brigit, van der Vliet, Nina, Furman, Eeva, Paloniemi, Riikka, Rekola, Aino, Aulake, Marianne, Byers, Vivienne, Gilmer, Alan, Huss, Anke, Vermeulen, Roel, Slama, Rémy, Samson, Michel, Albin, Maria, Grönlund, Åke, Garric, Jeanne, Stockholm University, Karolinska Institutet [Stockholm], Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), HERA (Health and Environment Research Agenda) Consortium: Robert Barouki, Manolis Kogevinas, Åke Bergman, Elina Drakvik, Anaïs Devouge, Denis Sarigiannis, Delphine Destoumieux-Garzón, Franziska Matthies-Wiesler, Annette Peters, Daniel Zalko, Cristina Villanueva, Cathryn Tonne, Elisabeth Cardis, Elizabeth Diago-Navarro, Josep M Antó, Maria Foraster, Mark Nieuwenhuijsen, Kurt Straif, Karin van Veldhoven, Kristine Belesova, Neil Pearce, Andy Haines, Jana Klánová, Kateřina Šebková, Lukáš Pokorný, Klára Hilscherová, Sandra Boekhold, Brigit Staatsen, Nina van der Vliet, Eeva Furman, Riikka Paloniemi, Aino Rekola, Marianne Aulake, Vivienne Byers, Alan Gilmer, Anke Huss, Roel Vermeulen, Rémy Slama, Michel Samson, Maria Albin, Åke Grönlund, Jeanne Garric, and Modat, Anne

Subjects
Transformational change, Health, Toxicology and Mutagenesis, Climate, Impact assessment, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Climate Change, Urbanization, Public Health, Environmental and Occupational Health, Research agenda, Infrastructures, Europe, [SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Humans, Chemicals, Cities, Impact Assessment, Research Agenda, Transformational Change, Ecosystem
Abstract

Climate change, urbanisation, chemical pollution and disruption of ecosystems, including biodiversity loss, affect our health and wellbeing. Research is crucial to be able to respond to the current and future challenges that are often complex and interconnected by nature. The HERA Agenda, summarised in this commentary, identifies six thematic research goals in the environment, climate and health fields. These include research to 1) reduce the effects of climate change and biodiversity loss on health and environment, 2) promote healthy lives in cities and communities, 3) eliminate harmful chemical exposures, 4) improve health impact assessment and implementation research, 5) develop infrastructures, technologies and human resources and 6) promote research on transformational change towards sustainability. Numerous specific recommendations for research topics, i.e., specific research goals, are presented under each major research goal. Several methods were used to define the priorities, including web-based surveys targeting researchers and stakeholder groups as well as a series of online and face-to-face workshops, involving hundreds of researchers and other stakeholders. The results call for an unprecedented effort to support a better understanding of the causes, interlinkages and impacts of environmental stressors on health and the environment. This will require breakdown of silos within policies, research, actors as well as in our institutional arrangements in order to enable more holistic approaches and solutions to emerge. The HERA project has developed a unique and exciting opportunity in Europe to consensuate priorities in research and strengthen research that has direct societal impact. The HERA project was funded from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 825417.

Published
2021
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180. Enjeux de la transition écologique

Author

Audouin, Laurent, Baudry, Emmanuelle, Bellard, Céline, Bonnaud, Elsa, Bopp, Laurent, Braconnot, Pascale, Breon, Francois-Marie, Brett, Raphael, Brunelle, Thierry, Bureau, Jean-Christophe, Chiron, François, Courchamp, Franck, da Cunha, Charlotte, Delmotte, Marc, Delpierre, Nicolas, de Noblet Ducoudré, Nathalie, Even, Catherine, Farinetti, Aude, Frascaria, Nathalie, Gherardi, Jeanne, Gouyon, Pierre‐henri, Hatté, Christine, Lantz, Frédéric, Larrère, Catherine, Leadley, Paul, Lecomte, Jane, Levi, Yves, Levrel, Harold, Lourtioz, Jean-Michel, Masson-Delmotte, Valérie, Mougin, Christian, Petit, Jean-Eudes, Ramstein, Gilles, Remvikos, Yorghos, Richecoeur, Franck, Roux, Guillaume, Saunois, Marielle, Servonnat, Jérôme, Slama, Rémy, Laval-Szopa, Sophie, Kiem, Cécile Tran, Treiner, Jacques, Vallet, Améline, Vanderlinden, Jean-Paul, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Modelling the Earth Response to Multiple Anthropogenic Interactions and Dynamics (MERMAID), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Modélisation INVerse pour les mesures atmosphériques et SATellitaires (SATINV), Institut d'Etudes de Droit Public (IEDP), Université Paris-Saclay, Centre International de Recherche sur l'Environnement et le Développement (CIRED), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École des hautes études en sciences sociales (EHESS)-AgroParisTech-École des Ponts ParisTech (ENPC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Département Environnements et Sociétés (Cirad-ES), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), AgroParisTech, Cultures, Environnements, Arctique, Représentations, Climat (CEARC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), ICOS-RAMCES (ICOS-RAMCES), Extrèmes : Statistiques, Impacts et Régionalisation (ESTIMR), Laboratoire de Physique des Solides (LPS), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Glaces et Continents, Climats et Isotopes Stables (GLACCIOS), Muséum national d'Histoire naturelle (MNHN), Institut d'Études Politiques [IEP] - Paris, Géochrononologie Traceurs Archéométrie (GEOTRAC), IFP School, Université Paris 1 Panthéon-Sorbonne (UP1), Centre de Nanosciences et de Nanotechnologies (C2N), Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Chimie Atmosphérique Expérimentale (CAE), Modélisation du climat (CLIM), Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion (EM2C), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP), Sorbonne Université (SU), The Shift Project, Redesigning the Economy to Achieve Carbon Transition, programme : Investissement d'Avenir, and LE PIOLET, DELPHINE

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences, PANOPLY
Abstract

International audience; Cet ouvrage, aux nombreuses illustrations, donne une vision transversale des changements environnementaux d'échelle mondiale que connaît notre planète aux limites finies. Son objectif est, en particulier, de faire comprendre les mécanismes et conséquences du réchauffement climatique et de l'érosion de la biodiversité ainsi que leurs relations avec nos modes de vie et de consommation. Pour l'essentiel, il reprend l'un des premiers enseignements numériques délivrés à grande échelle en 2020 sur les « Enjeux de la transition écologique » auprès de plusieurs milliers d'étudiants de licence de toutes disciplines de l'Université Paris-Saclay. À l'instar de ce cours, cet ouvrage s'articule en quatre parties. Partant d'une perspective historique des évolutions du climat et de la biodiversité, les trois premières parties annoncent l'impact croissant de l'humanité sur les flux d'énergie et de matière de la planète et sur les trajectoires évolutives du vivant. Cet impact conditionne en retour la survie de nos sociétés et du monde tel que nous le savons. La quatrième et dernière partie de cet ouvrage offre un cadre de réflexions pour une transition vers un développement soutenable. Cette transition peut être une opportunité pour rembourser nos façons de produire, de travailler, de consommer, de nous déplacer, tout en visant l'équité sociale pour un « bien vivre ensemble » partagé sur la planète. Pour répondre à l'objectif de transversalité de l'ouvrage, plus de quarante enseignant(e)s-chercheurs(s) et chercheurs(euses) d'horizons différents y ont contribué, mêlant les savoirs des sciences de la nature aux sciences humaines et sociales en passant par le droit, l'économie, la gestion, l'agronomie et la médecine.

Published
2021
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181. Impacts des changements climatiques

Author

Laval-Szopa, Sophie, de Noblet Ducoudré, Nathalie, Bopp, Laurent, Slama, Rémy, Kiem, Cécile Tran, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Modélisation du climat (CLIM), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Extrèmes : Statistiques, Impacts et Régionalisation (ESTIMR), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris], programme : Investissement d'Avenir, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Institut Pasteur [Paris] (IP), and LE PIOLET, DELPHINE

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

184. Do Income and Employment Uncertainty Affect Couple Stability? Evidence for France During the COVID-19 Pandemic.

Author

Barbuscia, Anna, Pailhé, Ariane, Solaz, Anne, Bajos, Nathalie, Warszawski, Josiane, Bagein, Guillaume, Beck, François, Counil, Emilie, Jusot, Florence, Lydie, Nathalie, Martin, Claude, Meyer, Laurence, Raynaud, Philippe, Rouquette, Alexandra, Rahib, Delphine, Sicard, Patrick, Slama, Rémy, and Spire, Alexis

Abstract

Economic uncertainty and family dynamics are strictly connected. The increasing uncertainty generated by the Covid-19 pandemic is thus likely to affect couple relationships and stability, with potential opposite effects. Using data from the nationally representative EPICOV survey, that followed individuals throughout the first year of pandemic in France, we examined separation rates and how these were associated with different measures of employment and income uncertainty, including both pre-pandemic conditions and changes occurred during and after the first lockdown in Spring 2020 in France. Our results show increased rates of separation, especially among younger people, during the 6 months after the first lockdown, and a return to rates more similar to those observed in usual times, afterwards. Individuals who were unemployed and had lower income before the beginning of the pandemic were more likely to separate soon after the lockdown, while changes in employment conditions due to the lockdown were not linked with a higher separation risk. The job protection and the income compensation provided by the French state, as well a less stigmatising effect of unemployment occurred during the covid crisis, may explain the absence of effect. Self-declared deterioration in financial condition, especially when declared by men, was associated with higher separation risk for the whole year of observation. [ABSTRACT FROM AUTHOR]

Published
2023
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185. Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study.

Author

Marsal, Anouk, Slama, Rémy, Lyon-Caen, Sarah, S. Borlaza, Lucille Joanna, Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaëlle, Siroux, Valérie, and the SEPAGES cohort study group

Subjects
*LUNG physiology, *PARTICULATE matter, *MATERNAL exposure, *STATISTICS, *CONFIDENCE intervals, *MULTIPLE regression analysis, *PRENATAL exposure delayed effects, *PULMONARY function tests, *DESCRIPTIVE statistics, *RESEARCH funding, *BIOLOGICAL assay, *BREATH tests, *DATA analysis software, *OXIDATION-reduction reaction, *LONGITUDINAL method, *PREGNANCY
Abstract

BACKGROUND: Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of personal exposure to PM2.5  and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. METHODS: We used data from 356 mother–child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5  mass and OP with lung function parameters were estimated using multiple linear regressions. RESULTS: In neonates, an interquartile (IQR) increase in OPDTTv (0.89nmol/min/m³) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW  [β = -2.26 mL ; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5  showed similar patterns in comparison with OPDTTv  but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPDTTv  (β = 0.09hPa×s/L ; 95% CI: -0.06, 0.24) and OPAAv  (IQR = 1.14nmol/min/m³ ; β = 0.12hPa×s/L ; 95% CI: -0.04, 0.27) but not with PM2.5  (IQR = 6.9µg/m³ ; β = 0.02hPa×s/L ; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5. DISCUSSION: Prenatal exposure to OPDTTv was associated with several offspring lung function parameters over time, all related to lung volumes. [ABSTRACT FROM AUTHOR]

Published
2023
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186. 4% de la population a développé des anticorps contre le SARS-CoV-2 entre mai et novembre 2020

Author

Warszawski, Josiane, Bajos, Nathalie, Costemalle, Vianney, Leblanc, Salomé, Bagein, Guillaume, Calandra, Carmen, Counil, Emilie, Deroyon, Thomas, Franck, Jeanna-Eve, Gosselin, Anne, Jusot, Florence, Kreling, Robin, de Lamballerie, Xavier, Leduc, Aude, Lydié, Nathalie, Martin, Claude, Meyer, Laurence, Novelli, Sophie, Pailhé, Ariane, Rahib, Delphine, Raynaud, Philippe, Sillard, Patrick, Slama, Rémy, and Spire, Alexis

Abstract

Six mois après un premier volet réalisé en mai 2020, l’enquête nationale Épidémiologie et Conditions de vie (EpiCov) révèle que 6,2 % de la population possède des anticorps contre le SARS-CoV-2 en novembre 2020, en France métropolitaine, chez les personnes de 15 ans ou plus hors Ehpad. Cette séroprévalence est inférieure à la proportion de personnes ayant été contaminées par le virus depuis le début de l’épidémie, car les anticorps peuvent disparaître avec le temps chez les personnes infectées. Entre mai et novembre 2020, on estime que 4,0 % de la population a développé des anticorps contre le virus, portant la part de la population contaminée par le virus depuis le début de l’épidémie à au moins 8,5 % en novembre 2020. En Île-de-France, le niveau de séroprévalence reste le plus élevé, avec 11 % des Franciliens de 15 ans ou plus ayant des anticorps en novembre 2020, devant l’Auvergne-Rhône-Alpes (8,4 %). Par ailleurs, contrairement à la première vague épidémique, les adolescents et les jeunes adultes ont été plus touchés par le virus que les adultes d’âges intermédiaires lors de la seconde vague : 10,1 % des 15 à 20 ans ont des anticorps, contre 6,7 % des 30 à 49 ans et 4 % des plus de 64 ans. Vivre dans une zone à forte densité de population ou exercer une profession essentielle dans le domaine du soin reste associé, comme lors de la première vague, à une séroprévalence plus élevée.

Published
2021

187. Disparities in particulate matter (PM10) origins and oxidative potential at a city-scale (Grenoble, France) – Part II: Sources of PM10 oxidative potential using multiple linear regression analysis and the predictive applicability of multilayer perceptron neural network analysis

Author

Borlaza, Lucille Joanna S., Weber, Samuël, Jaffrezo, Jean-Luc, Houdier, Stephan, Slama, Rémy, Rieux, Camille, Albinet, Alexandre, Micallef, Steve, Trébluchon, Cécile, and Uzu, Gaëlle

Abstract

The oxidative potential (OP) of particulate matter (PM) quantifies PM capability to cause anti-oxidant imbalance. Due to the wide range and complex mixture of species in particulates, little is known on the pollution sources most strongly contributing to OP. A one-year sampling of PM10 (particles with an aerodynamic diameter below 10) was performed over different sites in a medium-sized city (Grenoble, France). An enhanced fine-scale apportionment of PM10 sources, based on the chemical composition, was performed using Positive Matrix Factorization (PMF) method and reported in a companion paper (Borlaza et al., 2020). OP was assessed as the ability of PM10 to generate reactive oxygen species (ROS) using three different acellular assays: Dithiothreitol (DTT), Ascorbic acid (AA), and 2,7-dichlorofluorescein (DCFH) assays. Using multiple linear regression (MLR), the OP contribution of the sources identified by PMF were estimated. Conversely, since atmospheric processes are usually non-linear in nature, artificial neural network (ANN) techniques, which employs non-linear models, could further improve estimates. Hence, the multilayer perceptron analysis (MLP), an ANN-based model, was additionally used to model OP based on PMF-resolved sources as well. This study presents the spatiotemporal variabilities of OP activity with influences by season-specific sources, site typology and specific local features, and assay sensitivity. Overall, both MLR and MLP effectively captured the evolution of OP. The primary traffic and biomass burning sources were the strongest drivers of OP in the Grenoble basin. There is also a clear redistribution of source-specific impacts when using OP instead of mass concentration, underlining the importance of PM redox activity over mass concentration. Finally, the MLP generally offered improvements in OP prediction especially for sites where synergistic and/or antagonistic effects between sources are prominent, supporting the value of using ANN-based models to account for the non-linear dynamics behind the atmospheric processes affecting OP of PM10.

Published
2021

188. Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms

Author

Lemire, Pierre, Temam, Sofia, Quinot, Catherine, Sévin, Etienne, Remacle, Sophie, Supernant, Karine, Dumas, Orianne, Le Moual, Nicole, Eyriey, E., Licinia, A., Vellement, A., Pin, Isabelle, Hofmann, P., Hullo, Églantine, Llerena, Catherine, Morin, X., Morlot, A., Lepeule, Johanna, Lyon-Caen, Sarah, Philippat, Claire, Quentin, Joane, Siroux, Valérie, Slama, Rémy, Faraldo, Beatrice, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, MGEN Foundation for Public Health [Paris] (FESP-MGEN), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), EpiConcept [Paris], The Sepages Study Group., Fondation d’entreprise MGEN pour la santé publique (FESP MGEN), Anses-PNR-EST-2015-1-022/Ademe-1594C0091, Anses-PNR-EST-2017-1-101/Ademe-1762C0021 Seventh Framework Programme, FP7: FP7/2007-206, N308333-HELIX European Research Council, ERC: N 311765-E-DOHaD Agence Nationale de la Recherche, ANR: 14-CE21-0007-01, 19-CE36-0003-01, ANR 18-CE36-005, ANR-12-PDOC-0029-01, ANR-15-IDEX, ANR-15-IDEX-02 Institut National de la Santé et de la Recherche Médicale, Inserm Fondation de France: CLI-MATHES—00081169 Commissariat Général à l'Investissement, CGI Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, ANSES: PNR-EST-2018-1-264 Agir pour les Maladies Chroniques, Acknowledgments: We acknowledge the role of SEPAGES cohort study group: E. Eyriey, A. Licinia, A. Vellement (Groupe Hospitalier Mutualiste, Grenoble), I. Pin, P. Hofmann, E. Hullo, C. Llerena (Grenoble University Hospital, La Tronche), X. Morin (Clinique des Cèdres, Echirolles), A. Morlot (Clinique Belledonne, Saint-Martin d’Hères), J. Lepeule, S. Lyon-Caen, C. Philippat, I. Pin, J. Quentin, V. Siroux, R. Slama (Inserm, CNRS, University Grenoble Alpes IAB research center). We thank A. Benlakhryfa, L. Borges, Y. Gioria, clinical research assistants, J. Giraud, M. Marceau, M.-P. Martin, nurses, E. Charvet, A. Putod, midwives, M. Graca, K. Gridel, C. Pelini, fieldworkers, K. Guichardet, A. Levanic, C. Martel, E. Quinteiro neuropsychologists, the sta↵ from Grenoble Center for Clinical Investigation (CIC): J.-L. Cracowski, C. Cracowski, E. Hodaj, D. Abry, N. Gonnet and A. Tournier. A warm thank you also to M. Althuser, S. Althuser, F. Camus-Chauvet, P. Dusonchet, S. Dusonchet, L. Emery, P. Fabbrizio, P. Ho↵mann, D. Marchal André, X. Morin, E. Opoix, L. Pacteau, P. Rivoire, A. Royannais, C. Tomasella, T. Tomasella, D. Tournadre, P. Viossat, E. Volpi, S. Rey, E. Warembourg and clinicians from Grenoble University Hospital for their support in the recruitment of the study volunteers. We also thank A. Buchet, S.F. Caraby, J.-N. Canonica, J. Dujourdil, E. Eyriey, P. Hofmann, M. Jeannin, A. Licina, X. Morin, A. Nicolas, and all midwives from the four maternity wards of Grenoble urban areas. We thank B. Chevolon, C. Cornes, A.S. Gauchez, D. Guergour, P. Faure, J. Arnaud for thyroid hormones assessment. We thank the team of L. Chaperod (EFS) for its implication on the immunological aspects of the project. We thank G. Uzu (IRD) and J.-L. Ja↵rezo (CNRS) for their implication on PM oxidative potential assessment. We thank F.-X. Leupert, O. Bonnet and L. Goirand for the access to the birth certificate database from the Conseil Général de l’Isère. Sépages biospecimens are stored at Grenoble University Hospital (CHU-GA) biobank (bb-0033-00069), we would like to thank the whole CRB team, led by P. Mossuz and P. Lorimier, and in particular the technicians for the huge work of biospecimens processing and pooling: W. Jayar and L. Than, as well as G. Schummer. The Internet platform for secured data collection was developed by Epiconcept Paris (E. Sevin, S. Ployart, A. Polaert). SEPAGES data are stored thanks to Inserm RE-CO-NAI platform funded by Commissariat Général à l’Investissement, with the implication of Sophie de Visme (Inserm DSI). Many thanks to M.A. Charles, RE-CO-NAI coordinator, for her support. Finally, and importantly, we would like to express our sincere thanks to participants of the SEPAGES study. The authors are grateful for the help received from Ines Taarit and Mathias Clément to update the cleaning products ingredients database., Funding: The cohort was supported by the European Research Council (consolidator grant N 311765-E-DOHaD, PI, R. Slama), by the European Community’s Seventh Framework Programme (FP7/2007-206, grant N308333-HELIX, PI, M. Vrijheid), by ANR, the French Research Agency (PAPER project ANR-12-PDOC-0029-01, PI, J. Lepeule, SHALCOH project, 14-CE21-0007-01, PI, R. Slama, GUMME project, PI, R. Slama, ETAPE ANR 18-CE36-005, PI, J. Lepeule, EDeN project 19-CE36-0003-01, SYMER project, ANR-15-IDEX-02, PI, U. Schlattner, Mobil’Air project, ANR-15-IDEX, PI, S. Mathy, supported by University Grenoble-3Alpes), by ANSES (CNAP and HYPAXE projects, PI C. Philippat, PENDORE project, PNR-EST-2018-1-264, PI, V. Siroux), by Plan Cancer (Canc’Air project, PI, P. Guénel), by Association de Recherche sur le Cancer (ARC, PI, P. Guénel), by AGIR pour les maladies chroniques (PI, R. Slama and PRENAPAR project, V. Siroux), and Fonds de Recherche pour la Santé Respiratoire (FRSR, PI, I. Pin) and by Fondation de France (CLI-MATHES—00081169, J. Lepeule). We acknowledge the support of ANSES, Inserm and AGIR pour les maladies chroniques, for SEPAGES feasibility study. The support of 'SCUSI 2017' Région Auvergne-Rhône-Alpes programme is also acknowledged. COBANET-Sepages project was support by Anses and Ademe (COBANET: Anses-PNR-EST-2015-1-022/Ademe-1594C0091, PI: N Le Moual, CRESPINET: Anses-PNR-EST-2017-1-101/Ademe-1762C0021, PI: N Le Moual). Pierre Lemire benefited from a PhD scholarship of the University of Paris-Sud/Paris-Saclay, France., The cohort was supported by the European Research Council (consolidator grant N 311765-E-DOHaD, PI, R. Slama), by the European Community?s Seventh Framework Programme (FP7/2007-206, grant N308333-HELIX, PI, M. Vrijheid), by ANR, the French Research Agency (PAPER project ANR-12-PDOC-0029-01, PI, J. Lepeule, and EDeN project 19-CE36-0003-01, SYMER project, ANR-15-IDEX-02, PI, U. Schlattner, Mobil?Air project, ANR-15-IDEX, PI, S. Mathy, supported by University Grenoble-3Alpes), by ANSES (CNAP and HYPAXE projects, PI C. Philippat, PENDORE project, PNR-EST-2018-1-264, PI, V. Siroux), by Plan Cancer (Canc?Air project, PI, P. Gu?nel), by Association de Recherche sur le Cancer (ARC, PI, P. Gu?nel), by AGIR pour les maladies chroniques (PI, R. Slama and PRENAPAR project, V. Siroux), and Fonds de Recherche pour la Sant? Respiratoire (FRSR, PI, I. Pin) and by Fondation de France (CLIMATHES?00081169, J. Lepeule). We acknowledge the support of ANSES, Inserm and AGIR pour les maladies chroniques, for SEPAGES feasibility study. The support of ?SCUSI 2017? R?gion Auvergne-Rh?ne-Alpes programme is also acknowledged. COBANET-Sepages project was support by Anses and Ademe (COBANET: Anses-PNR-EST-2015-1-022/Ademe-1594C0091, PI: N Le Moual

Subjects
medicine.medical_specialty, Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], lcsh:Medicine, Smartphone application, Logistic regression, Article, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Environmental health, Epidemiology, Odds Ratio, medicine, Humans, 030212 general & internal medicine, Association (psychology), smartphone application, Asthma, household cleaning products, business.industry, lcsh:R, Public Health, Environmental and Occupational Health, Asthma symptoms, Odds ratio, asthma, medicine.disease, 3. Good health, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Smartphone, business, Kappa, Disinfectants
Abstract

International audience; Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00–1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors.

Published
2021
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189. Designing local air pollution policies focusing on mobility and heating to avoid a targeted number of pollution-related deaths: forward and backward approaches combining air pollution modeling, health impact assessment, and cost-benefit analysis

Author

Bouscasse, Hélène, Gabet, Stephan, Kerneis, Glen, Provent, Ariane, Msc, Camille, Salem, Nabil, Troude, Florence, Mathy, Sandrine, Slama, Rémy, Centre d'Economie et de Sociologie Rurales Appliquées à l'Agriculture et aux Espaces Ruraux (CESAER), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Univ. Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, IAB, 38000 Grenoble, France, Laboratoire d'Economie Appliquée de Grenoble (GAEL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Atmo Auvergne-Rhône-Alpes, Grenoble, France, and BOUSCASSE, HELENE

Subjects
air pollution, health impact, [SHS] Humanities and Social Sciences, mode choice scenarios, [SHS]Humanities and Social Sciences
Abstract

Public policies aiming at decreasing air pollutants such as fine particulate matter (PM2.5) are often designed without targeting an explicit health benefit and without carrying out cost-benefit analyses, therefore possibly limiting their adoption.We developed a transdisciplinary backward and forward approach at the conurbation level (Grenoble, France): we first defined health objectives, identified which PM2.5 reductions and urban policies allowed to meet the health targets (backward approach), and finally conducted health impact and cost-benefit analyses of these policies (forward approach). Three health targets were defined, corresponding to decreases by 33%, 50% and 67% in PM2.5-attributable mortality in 2030, compared to 2016. The urban policies were related to the wood heating and transport sectors, the main emitting sectors in the considered area. The forward approach considered the health impact and co-benefits of these policies also related to changes in physical activity and GHG emissions.The most ambitious health target could be achieved in 2030 by replacing all inefficient wood heating equipment by pellet stoves and by reducing by 36% the traffic of private motorized vehicles. Such a reduction requires to increase active modes share (walking, biking…), which would also induce increases in physical activity and additional health benefits beyond the initial target. Wood heating system replacement and strategies maximizing active mobility, which did not require massive investment in public transport, were the most cost-effective policies. For each Euro invested, the total benefit was about 30€ for policies focusing on wood heating, and 1 to 66€ for policies on traffic. Annual net benefits were between €468 and €615 per capita for policies with report on active transportation modes, compared to between €151 and €258 without.Urban policies strongly reducing air pollution-attributable mortality can be identified by backward transdisciplinary approaches, and be cost-efficient.

Published
2021

190. Disparities in particulate matter (PM10) origins and oxidative potential at a city scale (Grenoble, France) – Part 1: Source apportionment at three neighbouring sites

Author

Borlaza, Lucille Joanna S., Weber, Samuël, Uzu, Gaëlle, Jacob, Véronique, Cañete, Trishalee, Micallef, Steve, Trébuchon, Cécile, Slama, Rémy, Favez, Olivier, Jaffrezo, Jean-Luc, Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), ATMO Auvergne-Rhône-Alpes (ATMO-AURA), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut National de l'Environnement Industriel et des Risques (INERIS), and Civs, Gestionnaire

Subjects
[SDE] Environmental Sciences, [PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], [SDE]Environmental Sciences, [PHYS.PHYS.PHYS-AO-PH] Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph]
Abstract

A fine-scale source apportionment of PM10 was conducted in three different urban sites (background, hyper-center, and peri-urban) within 15 km of the city in Grenoble, France using Positive Matrix Factorization (PMF 5.0) on measured chemical species from collected filters (24 h) from February 2017 to March 2018. To improve the PMF solution, several new organic tracers (3-MBTCA, pinic acid, phthalic acid, MSA, and cellulose) were additionally used in order to identify sources that are commonly unresolved by classic PMF methodologies. An 11-factor solution was obtained in all sites, including commonly identified sources from primary traffic (13 %), nitrate-rich (17 %), sulfate-rich (17 %), industrial (1 %), biomass burning (22 %), aged sea salt (4 %), sea/road salt (3 %), and mineral dust (7 %), and the newly found sources from primary biogenic (4 %), secondary biogenic oxidation (10 %), and MSA-rich (3 %). Generally, the chemical species exhibiting similar temporal trends and strong correlations showed uniformly distributed emission sources in the Grenoble basin. The improved PMF model was able to obtain and differentiate chemical profiles of specific sources even at high proximity of receptor locations, confirming its applicability in a fine-scale resolution. In order to test the similarities between the PMF-resolved sources, the Pearson distance and standardized identity distance (PD-SID) of the factors in each site were compared. The PD-SID metric determined whether a given source is homogeneous (i.e., with similar chemical profiles) or heterogeneous over the three sites, thereby allowing better discrimination of localized characteristics of specific sources. Overall, the addition of the new tracers allowed the identification of substantial sources (especially in the SOA fraction) that would not have been identified or possibly mixed with other factors, resulting in an enhanced resolution and sound source profile of urban air quality at a city scale.

Published
2021
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191. Disparities in particulate matter (PM10) origins and oxidative potential at a city scale (Grenoble, France) – Part 2: Sources of PM10 oxidative potential using multiple linear regression analysis and the predictive applicability of multilayer perceptron neural network analysis

Author

Borlaza, Lucille, Weber, Samuël, Jaffrezo, Jean-Luc, Houdier, Stephan, Slama, Rémy, Rieux, Camille, Albinet, Alexandre, Micallef, Steve, Trébluchon, Cécile, Uzu, Gaëlle, Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), ATMO Auvergne-Rhône-Alpes (ATMO-AURA), Institut National de l'Environnement Industriel et des Risques (INERIS), Civs, Gestionnaire, and ANR-19-CE34-0002,GET_OP_STAND_OP,A la croisée de la Géochimie, de l'Exposition et de la sanTé : une première STANDardisation du Potentiel Oxydant des PM avant l'OPérationnalité.(2019)

Subjects
[SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, [SDU.OCEAN] Sciences of the Universe [physics]/Ocean, Atmosphere
Abstract

The oxidative potential (OP) of particulate matter (PM) measures PM capability to potentially cause anti-oxidant imbalance. Due to the wide range and complex mixture of species in particulates, little is known about the pollution sources most strongly contributing to OP. A 1-year sampling of PM10 (particles with an aerodynamic diameter below 10) was performed over different sites in a medium-sized city (Grenoble, France). An enhanced fine-scale apportionment of PM10 sources, based on the chemical composition, was performed using the positive matrix factorization (PMF) method and reported in a companion paper (Borlaza et al., 2020). OP was assessed as the ability of PM10 to generate reactive oxygen species (ROS) using three different acellular assays: dithiothreitol (DTT), ascorbic acid (AA), and 2,7-dichlorofluorescein (DCFH) assays. Using multiple linear regression (MLR), the OP contributions of the sources identified by PMF were estimated. Conversely, since atmospheric processes are usually non-linear in nature, artificial neural network (ANN) techniques, which employ non-linear models, could further improve estimates. Hence, the multilayer perceptron analysis (MLP), an ANN-based model, was additionally used to model OP based on PMF-resolved sources as well. This study presents the spatiotemporal variabilities of OP activity with influences by season-specific sources, site typology and specific local features, and assay sensitivity. Overall, both MLR and MLP effectively captured the evolution of OP. The primary traffic and biomass burning sources were the strongest drivers of OP in the Grenoble basin. There is also a clear redistribution of source-specific impacts when using OP instead of mass concentration, underlining the importance of PM redox activity for the identification of potential sources of PM toxicity. Finally, the MLP generally offered improvements in OP prediction, especially for sites where synergistic and/or antagonistic effects between sources are prominent, supporting the value of using ANN-based models to account for the non-linear dynamics behind the atmospheric processes affecting OP of PM10.

Published
2021
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192. Réglementation

Author

Demy, Annabelle, primary, Michel, Cécile, additional, Slama, Rémy, additional, Aveline, Tiphaine, additional, Lemaitre, Cécile, additional, Giguelay, Anne, additional, and Lefèvre, Barbara, additional

Published
2021
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195. Pregnancy exposure to phthalates and placental DNA methylation in the French EDEN cohort

Author

Jedynak, Paulina, primary, Tost, Jörg, additional, Bourova Flin, Ekaterina, additional, Busato, Florence, additional, Forhan, Anne, additional, Heude, Barbara, additional, Jakobi, Milan, additional, Rousseaux, Sophie, additional, Schwartz, Joel, additional, Slama, Rémy, additional, Vaiman, Daniel, additional, Lepeule, Johanna, additional, and Philippat, Claire, additional

Published
2021
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196. Prenatal exposure to lipophilic endocrine-disrupting chemicals and liver injury in children using chemical mixture approaches

Author

Midya, Vishal, primary, Colicino, Elena, additional, Conti, David, additional, Berhane, Kiros, additional, Garcia, Erika, additional, Stratakis, Nikos, additional, Andrusaityte, Sandra, additional, Basagana, Xavier, additional, Grazuleviciene, Regina, additional, Haug, Line Småstuen, additional, Heude, Barbara, additional, Papadopoulou, Eleni, additional, McEachan, Rosemary, additional, Roumeliotaki, Theano, additional, Slama, Rémy, additional, Urquiza, Jose, additional, Vafeiadi, Marina, additional, Varo, Nerea, additional, Vos, Miriam B., additional, Wright, John, additional, Casas, Maribel, additional, McConnell, Rob, additional, Vrijheid, Martine, additional, Chatzi, Lida, additional, and Valvi, Damaskini, additional

Published
2021
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197. Phenols, phthalates and thyroid hormone levels during pregnancy; relying on toxicological data and Adverse Outcome Pathways to inform epidemiological analysis

Author

Nakiwala, Dorothy, primary, Noyes, Pamela D., additional, Faure, Patrice, additional, Chovelon, Benoît, additional, Corne, Christelle, additional, Gauchez, Anne Sophie, additional, Guergour, Dorra, additional, Lyon Caen, Sarah, additional, Sakhi, Amrit K., additional, Sabaredzovic, Azemira, additional, Thomsen, Cathrine, additional, Pin, Isabelle, additional, Slama, Rémy, additional, and Philippat, Claire, additional

Published
2021
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199. Association between household cleaning product profiles evaluated by the Ménag'Score® index and asthma symptoms among women from the SEPAGES cohort.

Author

Lemire, Pierre, Chevallier, Emmanuel, Lyon-Caen, Sarah, Sévin, Etienne, Boudier, Anne, Pacheco Da Silva, Emilie, De Thuin, Christian, Slama, Rémy, Dumas, Orianne, Siroux, Valérie, Le Moual, Nicole, The SEPAGES Study Group, Eyriey, E., Licinia, A., Vellement, A., Pin, I., Hoffmann, P., Hullo, E., Llerena, C., and Morin, X.

Subjects
CLEANING compounds, HOME furnishings, HEALTH risk assessment, ASTHMA, DISEASE risk factors, HOUSEKEEPING
Abstract

Objective: Considering household disinfectants and cleaning products (HDCP) as mixture of ingredients, rather than each ingredient individually, might help in characterizing their role in asthma. We investigated the association between HDCP and asthma, using the recently developed Ménag'Score®, a health risk assessment score based on exhaustive ingredient lists of HDCP. Methods: The study is based on 103 female volunteers of the SEPAGES cohort (2014–2019), with repeated data (up to 3 collection times, 200 observations). HDCP use was assessed from a barcode-based smartphone application linked with an ingredient database. The Ménag'score® risks for health and environment were computed for each weekly used HDCP from their exhaustive ingredient data (from A: no known risk to E: highest risk). The association between the use of HDCP with a poor Ménag'score® (D or E; overall, health, environment scores) and asthma symptoms, was estimated by generalized estimating equations models adjusted for age, BMI and smoking status. Results: Participants were on average 33 years old, 11% smoked and 20% had at least one asthma symptom. The Ménag'score® was computed for 540 HDCP scanned by participants. Weekly use of HDCP with a poor Ménag'score®-health (around 60% of the participants) was associated with a higher risk of asthma symptoms (OR 3.13, 95% CI [1.32–7.43]). No association was observed for the Ménag'score®-environment. Conclusion: The use of HDCP with a poor Ménag'score®-health was associated with asthma symptoms. The results support the use of the Ménag'score®-health to further evaluate the health risks of HDCP in observational studies and as a potential public health tool. [ABSTRACT FROM AUTHOR]

Published
2022
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200. Disparities in particulate matter (PM10) origins and oxidative potential at a city-scale (Grenoble, France) – Part I: Source apportionment at three neighbouring sites

Author

Borlaza, Lucille Joanna S., Weber, Samuël, Uzu, Gaëlle, Jacob, Véronique, Cañete, Trishalee, Favez, Olivier, Micallef, Steve, Trébuchon, Cécile, Slama, Rémy, and Jaffrezo, Jean-Luc

Abstract

A fine-scale source apportionment of PM10 was conducted in three different urban sites (background, hyper-center, and peri-urban) within 15 km of the city in Grenoble, France using Positive Matrix Factorization (PMF 5.0) on measured chemical species from collected filters (24-hr) from February 2017 to March 2018. To improve the PMF solution, several new organic tracers (3-MBTCA, pinic acid, phthalic acid, MSA, and cellulose) were additionally used in order to identify sources that are commonly unresolved by classic PMF methodologies. An 11-factor solution was obtained in all sites including commonly identified sources from primary traffic, nitrate-rich, sulfate-rich, industrial, biomass burning, aged sea salt, sea/road salt, and mineral dust, and the newly found sources from primary biogenic, secondary biogenic oxidation, and MSA-rich. Generally, the chemical species exhibiting similar temporal trends and strong correlations showed uniformly distributed emission sources in the Grenoble basin. The improved PMF model was able to obtain and differentiate chemical profiles of specific sources even at high proximity of receptor locations confirming its applicability in a fine-scale resolution. In order to test the similarities between the PMF-resolved sources, the Pearson distance and standardized identity distance (PD-SID) of the factors in each site were compared. The PD-SID metric determined homogeneous sources (biomass burning, primary traffic, nitrate-rich, sulfate-rich, primary biogenic, MSA-rich, aged sea salt, and secondary biogenic oxidation) and heterogeneous sources (industrial, mineral dust, and sea/road salt) across different urban sites, thereby allowing to better discriminate localized characteristics of specific sources. Overall, the addition of the new tracers allowed the identification of substantial sources (especially in the SOA fraction) that would not have been identified or possibly mixed with other factors, resulting in an enhanced resolution and sound source profile of urban air quality at a city scale.

Published
2020

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