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151. Comparison of Bioinformatics Pipelines and Operating Systems for the Analyses of 16S rRNA Gene Amplicon Sequences in Human Fecal Samples

Author

Marizzoni, Moira, primary, Gurry, Thomas, additional, Provasi, Stefania, additional, Greub, Gilbert, additional, Lopizzo, Nicola, additional, Ribaldi, Federica, additional, Festari, Cristina, additional, Mazzelli, Monica, additional, Mombelli, Elisa, additional, Salvatore, Marco, additional, Mirabelli, Peppino, additional, Franzese, Monica, additional, Soricelli, Andrea, additional, Frisoni, Giovanni B., additional, and Cattaneo, Annamaria, additional

Published
2020
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152. FDG uptake of the normal spinal cord in PET/MR imaging

Author

Aiello, Marco, primary, Alfano, Vincenzo, additional, Salvatore, Elena, additional, Cavaliere, Carlo, additional, Picardi, Marco, additional, Pepa, Roberta Della, additional, Nicolai, Emanuele, additional, Soricelli, Andrea, additional, Vella, Alessandra, additional, Salvatore, Marco, additional, and Mascalchi, Mario, additional

Published
2020
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157. Digital biomarker‐based individualized prognosis for people at risk of dementia

Author

Buegler, Maximilian, primary, Harms, Robbert L., additional, Balasa, Mircea, additional, Meier, Irene B., additional, Exarchos, Themis, additional, Rai, Laura, additional, Boyle, Rory, additional, Tort, Adria, additional, Kozori, Maha, additional, Lazarou, Eutuxia, additional, Rampini, Michaela, additional, Cavaliere, Carlo, additional, Vlamos, Panagiotis, additional, Tsolaki, Magda, additional, Babiloni, Claudio, additional, Soricelli, Andrea, additional, Frisoni, Giovanni, additional, Sanchez‐Valle, Raquel, additional, Whelan, Robert, additional, Merlo‐Pich, Emilio, additional, and Tarnanas, Ioannis, additional

Published
2020
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158. KCTD15 is overexpressed in human childhood B-cell acute lymphoid leukemia

Author

Smaldone, Giovanni, primary, Beneduce, Giuliana, additional, Incoronato, Mariarosaria, additional, Pane, Katia, additional, Franzese, Monica, additional, Coppola, Luigi, additional, Cordella, Angela, additional, Parasole, Rosanna, additional, Ripaldi, Mimmo, additional, Nassa, Giovanni, additional, Soricelli, Andrea, additional, Vitagliano, Luigi, additional, Mirabelli, Peppino, additional, and Salvatore, Marco, additional

Published
2019
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159. Integrated imaging of adrenal oncocytoma: a case of diagnostic challenge

Author

Coppola, Milena, primary, Romeo, Valeria, additional, Verde, Francesco, additional, Raia, Giorgio, additional, Mainolfi, Ciro Gabriele, additional, Aprea, Giovanni, additional, Guadagno, Elia, additional, Cavaliere, Carlo, additional, Baldi, Dario, additional, Soricelli, Andrea, additional, Mainenti, Pier Paolo, additional, and Maurea, Simone, additional

Published
2019
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161. Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease

Author

Pace, Leonardo, Perrone-Filardi, Pasquale, Mainenti, Pier Paolo, Prastaro, Mariella, Cuocolo, Alberto, Varrone, Andrea, Vezzuto, Pasquale, Crisci, Teresa, Soricelli, Andrea, Piscione, Federico, Chiariello, Massimo, and Salvatore, Marco

Published
1998
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163. DNA Methylation Profile of the SREBF2 Gene in Human Fetal Aortas.

Author

Schiano, Concetta, D'Armiento, Maria, Franzese, Monica, Castaldo, Rossana, Saccone, Gabriele, de Nigris, Filomena, Grimaldi, Vincenzo, Soricelli, Andrea, D'Armiento, Francesco Paolo, Zullo, Fulvio, and Napoli, Claudio

Subjects
DNA methylation, AORTA, HUMAN genes, MANN Whitney U Test, DISEASE risk factors, MATERNAL age, EPIGENOMICS
Abstract

Increasing evidence suggests that maternal cholesterol represents an important risk factor for atherosclerotic disease in offspring already during pregnancy, although the underlying mechanisms have not yet been elucidated. Eighteen human fetal aorta samples were collected from the spontaneously aborted fetuses of normal cholesterolemic and hypercholesterolemic mothers. Maternal total cholesterol levels were assessed during hospitalization. DNA methylation profiling of the whole SREBF2 gene CpG island was performed (p value <0.05). The Mann-Whitney U test was used for comparison between the 2 groups. For the first time, our study revealed that in fetal aortas obtained from hypercholesterolemic mothers, the SREBF2 gene shows 4 significant differentially hypermethylated sites in the 5′UTR-CpG island. This finding indicates that more effective long-term primary cardiovascular prevention programs need to be designed for the offspring of mothers with hypercholesterolemia. Further studies should be conducted to clarify the epigenetic mechanisms underlying the association between early atherogenesis and maternal hypercholesterolemia during pregnancy. [ABSTRACT FROM AUTHOR]

Published
2022
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164. ABCA1, TCF7, NFATC1, PRKCZ,and PDGFADNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome vianetwork analysis

Author

Infante, Teresa, Franzese, Monica, Ruocco, Antonio, Schiano, Concetta, Affinito, Ornella, Pane, Katia, Memoli, Domenico, Rizzo, Francesca, Weisz, Alessandro, Bontempo, Paola, Grimaldi, Vincenzo, Berrino, Liberato, Soricelli, Andrea, Mauro, Ciro, and Napoli, Claudio

Abstract

ABSTRACTAcute coronary syndrome (ACS) is the most severe clinical manifestation of coronary heart disease.We performed an epigenome-wide analysis of circulating CD4+and CD8+T cells isolated from ACS patients and healthy subjects (HS), enrolled in the DIANA clinical trial, by reduced-representation bisulphite sequencing (RRBS). In CD4+T cells, we identified 61 differentially methylated regions (DMRs) associated with 57 annotated genes (53% hyper- and 47% hypo-methylated) by comparing ACS patients vsHS. In CD8+T cells, we identified 613 DMRs associated with 569 annotated genes (28% hyper- and 72% hypo-methylated) in ACS patients as compared to HS. In CD4+vsCD8+T cells of ACS patients we identified 175 statistically significant DMRs associated with 157 annotated genes (41% hyper- and 59% hypo-methylated). From pathway analyses, we selected six differentially methylated hub genes (NFATC1, TCF7, PDGFA, PRKCB, PRKCZ, ABCA1) and assessed their expression levels by q-RT-PCR. We found an up-regulation of selected genes in ACS patients vsHS (P< 0.001). ABCA1, TCF7, PDGFA,and PRKCZgene expression was positively associated with CK-MB serum concentrations (r= 0.75, P= 0.03; r= 0.760, P= 0.029; r= 0.72, P= 0.044; r= 0.74, P= 0.035, respectively).This pilot study is the first single-base resolution map of DNA methylome by RRBS in CD4+and CD8+T cells and provides specific methylation signatures to clarify the role of aberrant methylation in ACS pathogenesis, thus supporting future research for novel epigenetic-sensitive biomarkers in the prevention and early diagnosis of this pathology.

Published
2022
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165. Plasma Aβ42 as biomarker of prodromal AD progression in patients with amnestic mild cognitive impairment: evidence from the PharmaCog/E-ADNI study

Author

Albani, Diego, Marizzoni, Moira, Ferrari, Clarissa, Fusco, Federica, Boeri, Lucia, Raimondi, Ilaria, Jovicich, Jorge, Babiloni, Claudio, Soricelli, Andrea, Lizio, Roberta, Galluzzi, Samantha, Cavaliere, Libera, Didic, Mira, Schönknecht, Peter, Molinuevo, José Luis, Nobili, Flavio, Parnetti, Lucilla, Payoux, Pierre, Bocchio, Luisella, Salvatore, Marco, Rossini, Paolo Maria, Tsolaki, Magda, Visser, Pieter Jelle, Richardson, Jill, Wiltfang, Jens, Bordet, Régis, Blin, Olivier, Forloni, Gianluigi, Frisoni, Giovanni, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri' [Milan, Italy], Centro San Giovanni di Dio, Fatebenefratelli, Brescia (IRCCS), Università degli Studi di Brescia = University of Brescia (UniBs), University of Trento [Trento], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), IRCCS-Hospital San Raffaele Pisana of Rome and Cassino, SDN - Istituto di Ricerca Diagnostica e Nucleare, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Universität Leipzig, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Università degli studi di Genova = University of Genoa (UniGe), Università degli Studi di Perugia = University of Perugia (UNIPG), Imagerie cérébrale et handicaps neurologiques (ICHN), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Aristotle University of Thessaloniki, Vrije Universiteit Medical Centre (VUMC), Vrije Universiteit Amsterdam [Amsterdam] (VU), GlaxoSmithKline [Stevenage, UK] (GSK), GlaxoSmithKline [Headquarters, London, UK] (GSK), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Georg-August-University = Georg-August-Universität Göttingen, CIDMA - University of Aveiro, Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), University of Duisburg-Essen, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
Clinical trial, Clusterin, amnesic mild cognitive impairment (aMCI), [SCCO.NEUR]Cognitive science/Neuroscience, mental disorders, PharmaCog project, Amyloid-beta peptide, Biomarkers, Prodromal Alzheimer's disease
Abstract

International audience; It is an open issue whether blood biomarkers serve to diagnose Alzheimer's disease (AD) or monitor its progression over time from prodromal stages. Here, we addressed this question starting from data of the European FP7 IMI-PharmaCog/E-ADNI longitudinal study in amnesic mild cognitive impairment (aMCI) patients including biological, clinical, neuropsychological (e.g., ADAS-Cog13), neuroimaging, and electroencephalographic measures. PharmaCog/E-ADNI patients were classified as "positive" (i.e., "prodromal AD" n = 76) or "negative" (n = 52) based on a diagnostic cut-off of Aβ42/P-tau in cerebrospinal fluid as well as APOE ε 4 genotype. Blood was sampled at baseline and at two follow-ups (12 and 18 months), when plasma amyloid peptide 42 and 40 (Aβ42, Aβ40) and apolipoprotein J (clusterin, CLU) were assessed. Linear Mixed Models found no significant differences in plasma molecules between the "positive" (i.e., prodromal AD) and "negative" groups at baseline. In contrast, plasma Aβ42 showed a greater reduction over time in the prodromal AD than the "negative" aMCI group (p = 0.048), while CLU and Aβ40 increased, but similarly in the two groups. Furthermore, plasma Aβ42 correlated with the ADAS-Cog13 score both in aMCI patients as a whole and the prodromal AD group alone. Finally, CLU correlated with the ADAS-Cog13 only in the whole aMCI group, and no association with ADAS-Cog13 was found for Aβ40. In conclusion, plasma Aβ42 showed disease progression-related features in aMCI patients with prodromal AD.

Published
2019

167. Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to alzheimer's and Parkinson's diseases (vol 129, pg 766, 2018)

Author

Babiloni, Claudio, Del Percio, Claudio, Lizio, Roberta, Noce, Giuseppe, Lopez, Susanna, Soricelli, Andrea, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco, Stirpe, Paola, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Garn, Heinrich, Fraioli, Lucia, Pievani, Michela, D'Antonio, Fabrizia, De Lena, Carlo, Güntekin, Bahar, Hanoğlu, Lütfü, Başar, Erol, Yener, Görsev, Emek Savaş, Derya Durusu, Triggiani, Antonio Ivano, Taylor, John Paul, De Pandis, Maria Francesca, Vacca, Laura, Frisoni, Giovanni B., Stocchi, Fabrizio, Tıp Fakültesi, and Güntekin, Bahar -- 0000-0002-0860-0524

Abstract

WOS: 000466778200028 PubMed ID: 30979693 Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. © 2018 International Federation of Clinical Neurophysiology

Published
2019

168. Plasma Aβ₄₂ as a biomarker of prodromal Alzheimer's disease progression in patients with amnestic mild cognitive impairment : Evidence from the PharmaCog/E-ADNI Study

Author

Albani, Diego, Marizzoni, Moira, Ferrari, Clarissa, Fusco, Federica, Boeri, Lucia, Raimondi, Ilaria, Jovicich, Jorge, Babiloni, Claudio, Soricelli, Andrea, Lizio, Roberta, Galluzzi, Samantha, Cavaliere, Libera, Didic, Mira, Schönknecht, Peter, Molinuevo, José Luis, Nobili, Flavio, Parnetti, Lucilla, Payoux, Pierre, Bocchio, Luisella, Salvatore, Marco, Rossini, Paolo Maria, Tsolaki, Magda, Visser, Pieter Jelle, Richardson, Jill C., Wiltfang, Jens, Bordet, Régis, Blin, Olivier, Forloni, Gianluigi, and Frisoni, Giovanni B.

Subjects
Medizin
Published
2019

171. Evaluation of the Diagnostic Performance of Positron Emission Tomography/Magnetic Resonance for the Diagnosis of Liver Metastases.

Author

Caiyuan Zhang, O'Shea, Aileen, Parente, Chiara Anna, Amorim, Barbara Juarez, Caravan, Peter, Ferrone, Christina R., Blaszkowsky, Lawrence S., Soricelli, Andrea, Salvatore, Marco, Groshar, David, Bernstine, Hanna, Domachevsky, Liran, Canamaque, Lina Garcia, Umutlu, Lale, Ken, Herrmann, Catana, Ciprian, Mahmood, Umar, and Catalano, Onofrio Antonio

Published
2021
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172. Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients.

Author

Quattrini, Giulia, Marizzoni, Moira, Pizzini, Francesca B., Galazzo, Ilaria Boscolo, Aiello, Marco, Didic, Mira, Soricelli, Andrea, Albani, Diego, Romano, Melissa, Blin, Olivier, Forloni, Gianluigi, Golay, Xavier, Jovicich, Jorge, Nathan, Pradeep J., Richardson, Jill C., Salvatore, Marco, Frisoni, Giovanni B., Pievani, Michela, and PharmaCog Consortium

Subjects
AMNESTIC mild cognitive impairment, MILD cognitive impairment, DEFAULT (Finance), TEST validity, TAU proteins, PERFUSION
Abstract

Background: Previous studies reported default mode network (DMN) and limbic network (LIN) brain perfusion deficits in patients with amnestic mild cognitive impairment (aMCI), frequently a prodromal stage of Alzheimer's disease (AD). However, the validity of these measures as AD markers has not yet been tested using MRI arterial spin labeling (ASL).Objective: To investigate the convergent and discriminant validity of DMN and LIN perfusion in aMCI.Methods: We collected core AD markers (amyloid-β 42 [Aβ42], phosphorylated tau 181 levels in cerebrospinal fluid [CSF]), neurodegenerative (hippocampal volumes and CSF total tau), vascular (white matter hyperintensities), genetic (apolipoprotein E [APOE] status), and cognitive features (memory functioning on Paired Associate Learning test [PAL]) in 14 aMCI patients. Cerebral blood flow (CBF) was extracted from DMN and LIN using ASL and correlated with AD features to assess convergent validity. Discriminant validity was assessed carrying out the same analysis with AD-unrelated features, i.e., somatomotor and visual networks' perfusion, cerebellar volume, and processing speed.Results: Perfusion was reduced in the DMN (F = 5.486, p = 0.039) and LIN (F = 12.678, p = 0.004) in APOE ɛ4 carriers compared to non-carriers. LIN perfusion correlated with CSF Aβ42 levels (r = 0.678, p = 0.022) and memory impairment (PAL, number of errors, r = -0.779, p = 0.002). No significant correlation was detected with tau, neurodegeneration, and vascular features, nor with AD-unrelated features.Conclusion: Our results support the validity of DMN and LIN ASL perfusion as AD markers in aMCI, indicating a significant correlation between CBF and amyloidosis, APOE ɛ4, and memory impairment. [ABSTRACT FROM AUTHOR]

Published
2021
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176. Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease

Author

Catalano, Onofrio Antonio, Wu, Vincent, Mahmood, Umar, Alberto Signore, Vangel, Mark, Soricelli, Andrea, Salvatore, Marco, Gervais, Debra, and Rosen, Bruce R.

Subjects
FDG-PET/MR, active inflammation, Crohn disease, CHILDREN, CANCER-PATIENTS, F-18-FDG PET/CT, PET/MR, inflammation, POSITRON-EMISSION-TOMOGRAPHY, DIFFUSION-WEIGHTED MRI, YOUNG-ADULTS, Original Article, BOWEL-DISEASE, NONINVASIVE ASSESSMENT, CT ENTEROGRAPHY
Abstract

This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

Published
2018

177. Predicting and Tracking Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer’s Disease: Structural Brain Biomarkers

Author

Marizzoni, Moira, Ferrari, Clarissa, Jovicich, Jorge, Albani, Diego, Babiloni, Claudio, Cavaliere, Libera, Didic, Mira, Forloni, Gianluigi, Galluzzi, Samantha, Hoffmann, Karl-Titus, Molinuevo, José Luis, Nobili, Flavio, Parnetti, Lucilla, Payoux, Pierre, Ribaldi, Federica, Rossini, Paolo Maria, Schönknecht, Peter, Salvatore, Marco, Soricelli, Andrea, Hensch, Tilman, Tsolaki, Magda, Visser, Pieter Jelle, Wiltfang, Jens, Richardson, Jill C, Bordet, Régis, Blin, Olivier, Frisoni, Giovanni B., The PharmaCog Consortium, Istituto Centro San Giovanni di Dio Fatebenefratelli, Partenaires INRAE, University of Trento [Trento], IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri' [Milan, Italy], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), San Raffaele Pisana IRCCS, Rome, Italy, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Universität Leipzig, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Università degli studi di Genova = University of Genoa (UniGe), Università degli Studi di Perugia = University of Perugia (UNIPG), Imagerie cérébrale et handicaps neurologiques (ICHN), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Brescia, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), SDN - Istituto di Ricerca Diagnostica e Nucleare, Aristotle University of Thessaloniki, Amsterdam UMC - Amsterdam University Medical Center, University of Duisburg-Essen, Georg-August-University = Georg-August-Universität Göttingen, Universidade de Aveiro, GlaxoSmithKline [Stevenage, UK] (GSK), GlaxoSmithKline [Headquarters, London, UK] (GSK), CHU Lille, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Université de Genève = University of Geneva (UNIGE), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Marizzoni, Moira, Frisoni, Giovanni, Neurology, and Amsterdam Neuroscience - Neurodegeneration

Subjects
0301 basic medicine, Oncology, Apolipoprotein E, Male, Medizin, 0302 clinical medicine, Cerebrospinal fluid, magnetic resonance imaging, medicine.diagnostic_test, General Neuroscience, Precision medicine, Brain, clinical trial, General Medicine, Alzheimer's disease, Middle Aged, 3. Good health, Clinical trial, Settore MED/26 - NEUROLOGIA, Psychiatry and Mental health, Clinical Psychology, Disease Progression, Biomarker (medicine), Female, Alzheimer’s disease, medicine.medical_specialty, biomarkers, mild cognitive impairment, precision medicine, Prodromal Symptoms, tau Proteins, Temporal lobe, 03 medical and health sciences, Atrophy, Magnetic resonance imaging, Alzheimer Disease, Internal medicine, medicine, Humans, Cognitive Dysfunction, Aged, Amyloid beta-Peptides, business.industry, Dentate gyrus, [SCCO.NEUR]Cognitive science/Neuroscience, Mild cognitive impairment, medicine.disease, 030104 developmental biology, Alzheimer’s disease, biomarkers, clinical trial, magnetic resonance imaging, mild cognitive impairment, precision medicine, ddc:618.97, Amnesia, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Biomarkers
Abstract

International audience; Background: Early Alzheimer's disease (AD) detection using cerebrospinal fluid (CSF) biomarkers has been recommended as enrichment strategy for trials involving mild cognitive impairment (MCI) patients.Objective: To model a prodromal AD trial for identifying MRI structural biomarkers to improve subject selection and to be used as surrogate outcomes of disease progression.Methods: APOE ɛ4 specific CSF Aβ42/P-tau cut-offs were used to identify MCI with prodromal AD (Aβ42/P-tau positive) in the WP5-PharmaCog (E-ADNI) cohort. Linear mixed models were performed 1) with baseline structural biomarker, time, and biomarker×time interaction as factors to predict longitudinal changes in ADAS-cog13, 2) with Aβ42/P-tau status, time, and Aβ42/P-tau status×time interaction as factors to explain the longitudinal changes in MRI measures, and 3) to compute sample size estimation for a trial implemented with the selected biomarkers.Results: Only baseline lateral ventricle volume was able to identify a subgroup of prodromal AD patients who declined faster (interaction, p = 0.003). Lateral ventricle volume and medial temporal lobe measures were the biomarkers most sensitive to disease progression (interaction, p≤0.042). Enrichment through ventricular volume reduced the sample size that a clinical trial would require from 13 to 76%, depending on structural outcome variable. The biomarker needing the lowest sample size was the hippocampal subfield GC-ML-DG (granule cells of molecular layer of the dentate gyrus) (n = 82 per arm to demonstrate a 20% atrophy reduction).Conclusion: MRI structural biomarkers can enrich prodromal AD with fast progressors and significantly decrease group size in clinical trials of disease modifying drugs.

Published
2018
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178. Corrigendum: Football Players Do Not Show “Neural Efficiency” in Cortical Activity Related to Visuospatial Information Processing During Football Scenes: An EEG Mapping Study

Author

Del Percio, Claudio, primary, Franzetti, Mauro, additional, De Matti, Adelaide Josy, additional, Noce, Giuseppe, additional, Lizio, Roberta, additional, Lopez, Susanna, additional, Soricelli, Andrea, additional, Ferri, Raffaele, additional, Pascarelli, Maria Teresa, additional, Rizzo, Marco, additional, Triggiani, Antonio Ivano, additional, Stocchi, Fabrizio, additional, Limatola, Cristina, additional, and Babiloni, Claudio, additional

Published
2019
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181. O5‐03‐04: ABNORMALITIES OF ELECTROENCEPHALOGRAPHIC (EEG) MARKERS IN QUIET WAKEFULNESS ARE RELATED TO MOTOR DEFICITS, COGNITIVE SYMPTOMS, AND VISUAL HALLUCINATIONS IN PARKINSON'S DISEASE PATIENTS

Author

Babiloni, Claudio, primary, Pascarelli, Maria Teresa, additional, Lizio, Roberta, additional, Noce, Giuseppe, additional, Lopez, Susanna, additional, Rizzo, Marco, additional, Ferri, Raffaele, additional, Soricelli, Andrea, additional, Nobili, Flavio, additional, Arnaldi, Dario, additional, Famà, Francesco, additional, Orzi, Francesco, additional, Buttinelli, Carla, additional, Giubilei, Franco, additional, Salvetti, Marco, additional, Cipollini, Virginia, additional, Bonanni, Laura, additional, Franciotti, Raffaella, additional, Onofrj, Marco, additional, Stirpe, Paola, additional, Fuhr, Peter, additional, Gschwandtner, Ute, additional, Ransmayr, Gerhard, additional, Aarsland, Dag, additional, Parnetti, Lucilla, additional, Farotti, Lucia, additional, Marizzoni, Moira, additional, D'Antonio, Fabrizia, additional, de Lena, Carlo, additional, Güntekin, Bahar, additional, Hanoğlu, Lutfu, additional, Yener, Görsev, additional, Emek-Savaş, Derya Durusu, additional, Triggiani, Antonio Ivano, additional, Taylor, John-Paul, additional, McKeith, Ian, additional, Stocchi, Fabrizio, additional, Vacca, Laura, additional, Hampel, Harald, additional, Frisoni, Giovanni B., additional, De Pandis, Maria Francesca, additional, and Del Percio, Claudio, additional

Published
2019
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182. P4-213: ALZHEIMER'S DISEASE PREDICTION SERVICE (ADPS): STANDARDIZING A DIGITAL BIOMARKER FOR COGNITION ASSESSMENT IN ALZHEIMER'S DISEASE CLINICAL TRIALS

Author

Tort, Adria, primary, Rai, Laura, additional, Boyle, Rory, additional, Kozori, Mahi, additional, Exarhos, Themis, additional, Rampini, Michela, additional, Cavaliere, Carlo, additional, Balasa, Mircea, additional, Vlamos, Panagiotis, additional, Tsolaki, Magda, additional, Babiloni, Claudio, additional, Soricelli, Andrea, additional, Frisoni, Giovanni B., additional, Sanchez-Valle, Raquel, additional, Whelan, Robert, additional, Robertson, Ian H., additional, and Tarnanas, Ioannis, additional

Published
2019
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183. O-16 Resting-state functional cortical connectivity are abnormal in HIV patients

Author

Noce, Giuseppe, primary, Percio, Claudio Del, additional, Lizio, Roberta, additional, Pascarelli, Maria Teresa, additional, Pennica, Alfredo, additional, Soricelli, Andrea, additional, Campli, Francesco Di, additional, Galli, Massimo, additional, Saracino, Annalisa, additional, Pietro, Massimo Di, additional, Vullo, Vincenzo, additional, Pagliano, Pasquale, additional, Perri, Giovanni Di, additional, Calcagno, Andrea, additional, Celesia, Benedetto Maurizio, additional, Ferracuti, Stefano, additional, Onorati, Paolo, additional, Andreoni, Massimo, additional, and Babiloni, Claudio, additional

Published
2019
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184. P3-168: FECAL MICROBIAL DIVERSITY IN ALZHEIMER'S PATIENTS

Author

Marizzoni, Moira, primary, Cattaneo, Annamaria, additional, Provasi, Stefania, additional, Ribaldi, Federica, additional, Andryszak, Paulina, additional, Festari, Cristina, additional, Lopizzo, Nicola, additional, Mazzelli, Monica, additional, Nicolosi, Valentina, additional, Salvatore, Marco, additional, Soricelli, Andrea, additional, and Frisoni, Giovanni B., additional

Published
2019
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185. P4-176: ABNORMALITIES OF CORTICAL NEURAL SYNCHRONIZATION MECHANISMS IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE AND EEG EPILEPTIFORM ACTIVITY

Author

Babiloni, Claudio, primary, Di Bonaventura, Carlo, additional, Noce, Giuseppe, additional, Lizio, Roberta, additional, Pascarelli, Maria Teresa, additional, Eldellaa, Ali Mohamed, additional, Soricelli, Andrea, additional, Ferri, Raffaele, additional, Nobili, Flavio Mariano, additional, Famà, Francesco, additional, Limatola, Cristina, additional, Palma, Eleonora, additional, Cifelli, Pierangelo, additional, Stocchi, Fabrizio, additional, Marizzoni, Moira, additional, Frisoni, Giovanni B., additional, and Del Percio, Claudio, additional

Published
2019
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186. P67-F rsEEG markers in subjects with MCI due to Alzheimer’s disease (ADMCI) and interictal epileptiform discharge

Author

Lizio, Roberta, primary, Babiloni, Claudio, additional, Bonaventura, Carlo Di, additional, Noce, Giuseppe, additional, Pascarelli, Maria Teresa, additional, Eldellaa, Dott. Ali, additional, Soricelli, Andrea, additional, Ferri, Raffaele, additional, Nobili, Flavio, additional, Famà, Francesco, additional, Limatola, Cristina, additional, Palma, Eleonora, additional, Cifelli, Pierangelo, additional, Stocchi, Fabrizio, additional, Marizzoni, Moira, additional, Frisoni, Giovanni B., additional, and Percio, Claudio Del, additional

Published
2019
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187. P4‐125: BIOINFORMATIC PIPELINE COMPARISON FOR COMPOSITIONAL ANALYSIS OF THE GUT MICROBIOME IN ALZHEIMER'S PATIENTS

Author

Marizzoni, Moira, primary, Provasi, Stefania, additional, Greub, Gilbert, additional, Gurry, Thomas, additional, Lopizzo, Nicola, additional, Ribaldi, Federica, additional, Salvatore, Marco, additional, Mirabelli, Peppino, additional, Soricelli, Andrea, additional, Frisoni, Giovanni B., additional, and Cattaneo, Annamaria, additional

Published
2019
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188. Circulating miRNAs in Untreated Breast Cancer: An Exploratory Multimodality Morpho-Functional Study

Author

Incoronato, Mariarosaria, primary, Grimaldi, Anna Maria, additional, Mirabelli, Peppino, additional, Cavaliere, Carlo, additional, Parente, Chiara Anna, additional, Franzese, Monica, additional, Staibano, Stefania, additional, Ilardi, Gennaro, additional, Russo, Daniela, additional, Soricelli, Andrea, additional, Catalano, Onofrio Antonio, additional, and Salvatore, Marco, additional

Published
2019
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189. Corrigendum to “Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer’s and Parkinson’s diseases” [Clin. Neurophysiol. 129 (2018) 766–782]

Author

Babiloni, Claudio, primary, Percio, Claudio Del, additional, Lizio, Roberta, additional, Noce, Giuseppe, additional, Lopez, Susanna, additional, Soricelli, Andrea, additional, Ferri, Raffaele, additional, Pascarelli, Maria Teresa, additional, Catania, Valentina, additional, Nobili, Flavio, additional, Arnaldi, Dario, additional, Famà, Francesco, additional, Orzi, Francesco, additional, Buttinelli, Carla, additional, Giubilei, Franco, additional, Bonanni, Laura, additional, Franciotti, Raffaella, additional, Onofrj, Marco, additional, Stirpe, Paola, additional, Fuhr, Peter, additional, Gschwandtner, Ute, additional, Ransmayr, Gerhard, additional, Garn, Heinrich, additional, Fraioli, Lucia, additional, Pievani, Michela, additional, D'Antonio, Fabrizia, additional, De Lena, Carlo, additional, Güntekin, Bahar, additional, Hanoğlu, Lutfu, additional, Başar, Erol, additional, Yener, Görsev, additional, Emek-Savaş, Derya Durusu, additional, Triggiani, Antonio Ivano, additional, Taylor, John Paul, additional, De Pandis, Maria Francesca, additional, Vacca, Laura, additional, Frisoni, Giovanni B., additional, and Stocchi, Fabrizio, additional

Published
2019
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190. Football Players Do Not Show “Neural Efficiency” in Cortical Activity Related to Visuospatial Information Processing During Football Scenes: An EEG Mapping Study

Author

Del Percio, Claudio, primary, Franzetti, Mauro, additional, De Matti, Adelaide Josy, additional, Noce, Giuseppe, additional, Lizio, Roberta, additional, Lopez, Susanna, additional, Soricelli, Andrea, additional, Ferri, Raffaele, additional, Pascarelli, Maria Teresa, additional, Rizzo, Marco, additional, Triggiani, Antonio Ivano, additional, Stocchi, Fabrizio, additional, Limatola, Cristina, additional, and Babiloni, Claudio, additional

Published
2019
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193. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats

Author

Ronsini Salvatore, D'Aniello Antimo, Soricelli Andrea, Topo Enza, and D'Aniello Gemma

Subjects
Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background D-aspartic acid is an amino acid present in neuroendocrine tissues of invertebrates and vertebrates, including rats and humans. Here we investigated the effect of this amino acid on the release of LH and testosterone in the serum of humans and rats. Furthermore, we investigated the role of D-aspartate in the synthesis of LH and testosterone in the pituitary and testes of rats, and the molecular mechanisms by which this amino acid triggers its action. Methods For humans: A group of 23 men were given a daily dose of D-aspartate (DADAVIT®) for 12 days, whereas another group of 20 men were given a placebo. For rats: A group of 10 rats drank a solution of either 20 mM D-aspartate or a placebo for 12 days. Then LH and testosterone accumulation was determined in the serum and D-aspartate accumulation in tissues. The effects of D-aspartate on the synthesis of LH and testosterone were gauged on isolated rat pituitary and Leydig cells. Tissues were incubated with D-aspartate, and then the concentration (synthesis) of LH and cGMP in the pituitary and of testosterone and cAMP in the Leydig cells was determined. Results In humans and rats, sodium D-aspartate induces an enhancement of LH and testosterone release. In the rat pituitary, sodium D-aspartate increases the release and synthesis of LH through the involvement of cGMP as a second messenger, whereas in rat testis Leydig cells, it increases the synthesis and release of testosterone and cAMP is implicated as second messenger. In the pituitary and in testes D-Asp is synthesized by a D-aspartate racemase which convert L-Asp into D-Asp. The pituitary and testes possesses a high capacity to trapping circulating D-Asp from hexogen or endogen sources. Conclusion D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats.

Published
2009
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197. Different Abnormalities of Cortical Neural Synchronization Mechanisms in Patients with Mild Cognitive Impairment due to Alzheimer’s and Chronic Kidney Diseases: An EEG Study

Author

Lizio, Roberta, primary, Babiloni, Claudio, additional, Del Percio, Claudio, additional, Losurdo, Antonia, additional, Vernò, Lucia, additional, De Tommaso, Marina, additional, Montemurno, Anna, additional, Dalfino, Giuseppe, additional, Cirillo, Pietro, additional, Soricelli, Andrea, additional, Ferri, Raffaele, additional, Noce, Giuseppe, additional, Pascarelli, Maria Teresa, additional, Catania, Valentina, additional, Nobili, Flavio, additional, Famá, Francesco, additional, Orzi, Francesco, additional, Giubilei, Franco, additional, Buttinelli, Carla, additional, Triggiani, A. Ivano, additional, Frisoni, Giovanni B., additional, Scisci, Anna Maria, additional, Mastrofilippo, Nicola, additional, Procaccini, Deni Aldo, additional, and Gesualdo, Loreto, additional

Published
2018
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199. Histogram analysis of DTI-derived indices reveals pontocerebellar degeneration and its progression in SCA2

Author

Mascalchi, Mario, primary, Marzi, Chiara, additional, Giannelli, Marco, additional, Ciulli, Stefano, additional, Bianchi, Andrea, additional, Ginestroni, Andrea, additional, Tessa, Carlo, additional, Nicolai, Emanuele, additional, Aiello, Marco, additional, Salvatore, Elena, additional, Soricelli, Andrea, additional, and Diciotti, Stefano, additional

Published
2018
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200. O1‐10‐04: ABNORMALITIES OF RESTING STATE FUNCTIONAL CORTICAL CONNECTIVITY IN PATIENTS WITH DEMENTIA DUE TO ALZHEIMER'S AND LEWY BODY DISEASES: AN EEG STUDY

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Lizio, Roberta, additional, Noce, Giuseppe, additional, Lopez, Susanna, additional, Soricelli, Andrea, additional, Ferri, Raffaele, additional, Nobili, Flavio Mariano, additional, Arnaldi, Dario, additional, Famà, Francesco, additional, Aarsland, Dag, additional, Orzi, Francesco, additional, Buttinelli, Carla, additional, Giubilei, Franco, additional, Onofrj, Marco, additional, Stocchi, Fabrizio, additional, Fuhr, Peter, additional, Gschwandtner, Ute, additional, Ransmayr, Gerhard, additional, Garn, Heinrich, additional, Frisoni, Giovanni B., additional, de Lena, Carlo, additional, Güntekin, Bahar, additional, Hanoğlu, Lutfu, additional, Başar, Erol, additional, Yener, Görsev, additional, Emek-Savas, Derya Durusu, additional, Triggiani, Antonio Ivano, additional, Franciotti, Raffaella, additional, Taylor, John-Paul, additional, Vacca, Laura, additional, De Pandis, Francesca, additional, and Bonanni, Laura, additional

Published
2018
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