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155. Intragenomic polymorphisms in the ITS region of high-quality genomes of the Hypoxylaceae (Xylariales, Ascomycota)

Author

Stadler, M., Stadler, Marc, Lambert, Christopher, Wibberg, Daniel, Kalinowski, Jörn, Cox, Russell J., Kolařík, Miroslav, Kuhnert, Eric, and HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

Subjects
0303 health sciences, Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie, biology, Pseudogene, Phylogenomics, biology.organism_classification, Agricultural and Biological Sciences (miscellaneous), Genome, 030308 mycology & parasitology, Xylaria hypoxylon, 03 medical and health sciences, Internal transcribed spacer, Evolutionary biology, Phylogenetics, ddc:570, Sordariomycetes, Xylariales, Gene, Ribosomal DNA, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology
Abstract

The internal transcribed spacer (ITS) region of the ribosomal DNA (rDNA) has been established (and is generally accepted) as a primary “universal” genetic barcode for fungi for many years, but the actual value for taxonomy has been heavily disputed among mycologists. Recently, twelve draft genome sequences, mainly derived from type species of the family Hypoxylaceae (Xylariales, Ascomycota) and the ex-epitype strain of Xylaria hypoxylon have become available during the course of a large phylogenomic study that was primarily aimed at establishing a correlation between the existing multi-gene-based genealogy with a genome-based phylogeny and the discovery of novel biosynthetic gene clusters encoding for secondary metabolites. The genome sequences were obtained using combinations of Illumina and Oxford nanopore technologies or PacBio sequencing, respectively, and resulted in high-quality sequences with an average N50 of 3.2 Mbp. While the main results will be published concurrently in a separate paper, the current case study was dedicated to the detection of ITS nrDNA copies in the genomes, in an attempt to explain certain incongruities and apparent mismatches between phenotypes and genotypes that had been observed during previous polyphasic studies. The results revealed that all of the studied strains had at least three copies of rDNA in their genomes, with Hypoxylon fragiforme having at least 19 copies of the ITS region, followed by Xylaria hypoxylon with at least 13 copies. Several of the genomes contained 2–3 copies that were nearly identical, but in some cases drastic differences, below 97% identity were observed. In one case, ascribable to the presence of a pseudogene, the deviations of the ITS sequences from the same genome resulted in only ca. 90% of overall homology. These results are discussed in the scope of the current trends to use ITS data for species recognition and segregation of fungi. We propose that additional genomes should be checked for such ITS polymorphisms to reassess the validity of this non-coding part of the fungal DNA for molecular identification.

Published
2020

156. Identification of species as producers of cyclodepsipeptide PF1022 A and resurrection of the genus as inferred from polythetic taxonomy

Author

Wittstein, K, Cordsmeier, A, Lambert, C, Wendt, L, Sir, E B, Weber, J, Wurzler, N, Petrini, L E, Stadler, M, and HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

Subjects
Dematophora obtusiostiolata (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora samuelsii (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora bunodes (Berk. & Broome) C. Lambert, K. Wittstein & M. Stadler, Dematophora freycinetiae (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora javaensis (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora macdonaldii (Bres.) C. Lambert, K. Wittstein & M. Stadler, Dematophora pyramidalis (Lar.N. Vassiljeva) C. Lambert, K. Wittstein & M. Stadler, Dematophora buxi (Fabre) C. Lambert, K. Wittstein & M. Stadler, Dematophora siggersii (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora francisiae (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora boedijnii (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora hughesii (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora puiggarii (Pat.) C. Lambert, K. Wittstein & M. Stadler, Dematophora obregonii (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Xylariaceae, PF1022A, Dematophora gigantea (Ellis & Everh.) C. Lambert, K. Wittstein & M. Stadler, Dematophora asperata (Massee ex Wakef.) Lambert, K. Wittstein & M. Stadler, Dematophora beccariana (Ces.) C. Lambert, K. Wittstein & M, Stadler, Dematophora acutispora (Theiss.) C. Lambert, K. Wittstein & M. Stadler, Dematophora grantii (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Isopimarane diterpenoids, Dematophora compacta (Takemoto) C. Lambert, K. Wittstein & M. Stadler, Rosellinia, Dematophora paraguayensis (Starbäck) C. Lambert, K. Wittstein & M. Stadler, Dematophora arcuata (Petch) C. Lambert, K. Wittstein & M. Stadler, Dematophora, Polythetic taxonomy, Dematophora hsiehiae (L.E. Petrini) C. Lambert, K. Wittstein & M. Stadler, Dematophora pepo (Pat.) C. Lambert, K. Wittstein & M. Stadler, Genus resurrection, Dematophora bothrina (Berk. & Broome) C. Lambert, K. Wittstein & M. Stadler
Abstract

Rosellinia (Xylariaceae) is a large, cosmopolitan genus comprising over 130 species that have been defined based mainly on the morphology of their sexual morphs. The genus comprises both lignicolous and saprotrophic species that are frequently isolated as endophytes from healthy host plants, and important plant pathogens. In order to evaluate the utility of molecular phylogeny and secondary metabolite profiling to achieve a better basis for their classification, a set of strains was selected for a multi-locus phylogeny inferred from a combination of the sequences of the internal transcribed spacer region (ITS), the large subunit (LSU) of the nuclear rDNA, beta-tubulin (TUB2) and the second largest subunit of the RNA polymerase II (RPB2). Concurrently, various strains were surveyed for production of secondary metabolites. Metabolite profiling relied on methods with high performance liquid chromatography with diode array and mass spectrometric detection (HPLC-DAD/MS) as well as preparative isolation of the major components after re-fermentation followed by structure elucidation using nuclear magnetic resonance (NMR) spectroscopy and high resolution mass spectrometry (HR-MS). Two new and nine known isopimarane diterpenoids were identified during our mycochemical studies of two selected Dematophora strains and the metabolites were tested for biological activity. In addition, the nematicidal cyclodepsipeptide PF1022 A was purified and identified from a culture of Rosellinia corticium, which is the first time that this endophyte-derived drug precursor has been identified unambiguously from an ascospore-derived isolate of a Rosellinia species. While the results of this first HPLC profiling were largely inconclusive regarding the utility of secondary metabolites as genus-specific chemotaxonomic markers, the phylogeny clearly showed that species featuring a dematophora-like asexual morph were included in a well-defined clade, for which the genus Dematophora is resurrected. Dematophora now comprises all previously known important plant pathogens in the genus such as D. arcuata, D. bunodes, D. necatrix and D. pepo, while Rosellinia s. str. comprises those species that are known to have a geniculosporium-like or nodulisporium-like asexual morph, or where the asexual morph remains unknown. The extensive morphological studies of L.E. Petrini served as a basis to transfer several further species from Rosellinia to Dematophora, based on the morphology of their asexual morphs. However, most species of Rosellinia and allies still need to be recollected in fresh state, cultured, and studied for their morphology and their phylogenetic affinities before the infrageneric relationships can be clarified.

Published
2020

172. Outline of Fungi and fungus-like taxa

Author

Wijayawardene, N. N., Hyde, K. D., Al-Ani, L. K. T., Tedersoo, L., Haelewaters, D., Rajeshkumar, K. C., Zhao, R. L., Aptroot, A., Leontyev, D., V, Saxena, R. K., Tokarev, Y. S., Dai, D. Q., Letcher, P. M., Stephenson, S. L., Ertz, D., Lumbsch, H. T., Kukwa, M., Issi, I., V, Madrid, H., Phillips, A. J. L., Selbmann, L., Pfliegler, W. P., Horvath, E., Bensch, K., Kirk, P. M., Kolarikova, K., Raja, H. A., Radek, R., Papp, V, Dima, B., Ma, J., Malosso, E., Takamatsu, S., Rambold, G., Gannibal, P. B., Triebel, D., Gautam, A. K., Avasthi, S., Suetrong, S., Timdal, E., Fryar, S. C., Delgado, G., Reblova, M., Doilom, M., Dolatabadi, S., Pawlowska, J. Z., Humber, R. A., Kodsueb, R., Sanchez-Castro, I, Goto, B. T., Silva, D. K. A., de Souza, F. A., Oehl, F. R., da Silva, G. A., Silva, I. R., Blaszkowski, J., Jobim, K., Maia, L. C., Barbosa, F. R., Fiuza, P. O., Divakar, P. K., Shenoy, B. D., Castaneda-Ruiz, R. F., Somrithipol, S., Lateef, A. A., Karunarathna, S. C., Tibpromma, S., Mortimer, P. E., Wanasinghe, D. N., Phookamsak, R., Xu, J., Wang, Y., Tian, F., Alvarado, P., Li, D. W., Kusan, I, Matocec, N., Mesic, A., Tkalcec, Z., Maharachchikumbura, S. S. N., Papizadeh, M., Heredia, G., Wartchow, F., Bakhshi, M., Boehm, E., Youssef, N., Hustad, V. P., Lawrey, J. D., Santiago, A. L. C. M. A., Bezerra, J. D. P., Souza-Motta, C. M., Firmino, A. L., Tian, Q., Houbraken, J., Hongsanan, S., Tanaka, K., Dissanayake, A. J., Monteiro, J. S., Grossart, H. P., Suija, A., Weerakoon, G., Etayo, J., Tsurykau, A., Vazquez, V., Mungai, P., Damm, U., Li, Q. R., Zhang, H., Boonmee, S., Lu, Y. Z., Becerra, A. G., Kendrick, B., Brearley, F. Q., Motiejunaite, J., Sharma, B., Khare, R., Gaikwad, S., Wijesundara, D. S. A., Tang, L. Z., He, M. Q., Flakus, A., Rodriguez-Flakus, P., Zhurbenko, M. P., McKenzie, E. H. C., Stadler, M., Bhat, D. J., Liu, J. K., Raza, M., Jeewon, R., Nassonova, E. S., Prieto, M., Jayalal, R. G. U., Erdogdu, M., Yurkov, A., Schnittler, M., Shchepin, O. N., Novozhilov, Y. K., Silva-Filho, A. G. S., Gentekaki, E., Liu, P., Cavender, J. C., Kang, Y., Mohammad, S., Zhang, L. F., Xu, R. F., Li, Y. M., Dayarathne, M. C., Ekanayaka, A. H., Wen, T. C., Deng, C. Y., Pereira, O. L., Navathe, S., Hawksworth, D. L., Fan, X. L., Dissanayake, L. S., Kuhnert, E., Thines, M., Wijayawardene, N. N., Hyde, K. D., Al-Ani, L. K. T., Tedersoo, L., Haelewaters, D., Rajeshkumar, K. C., Zhao, R. L., Aptroot, A., Leontyev, D., V, Saxena, R. K., Tokarev, Y. S., Dai, D. Q., Letcher, P. M., Stephenson, S. L., Ertz, D., Lumbsch, H. T., Kukwa, M., Issi, I., V, Madrid, H., Phillips, A. J. L., Selbmann, L., Pfliegler, W. P., Horvath, E., Bensch, K., Kirk, P. M., Kolarikova, K., Raja, H. A., Radek, R., Papp, V, Dima, B., Ma, J., Malosso, E., Takamatsu, S., Rambold, G., Gannibal, P. B., Triebel, D., Gautam, A. K., Avasthi, S., Suetrong, S., Timdal, E., Fryar, S. C., Delgado, G., Reblova, M., Doilom, M., Dolatabadi, S., Pawlowska, J. Z., Humber, R. A., Kodsueb, R., Sanchez-Castro, I, Goto, B. T., Silva, D. K. A., de Souza, F. A., Oehl, F. R., da Silva, G. A., Silva, I. R., Blaszkowski, J., Jobim, K., Maia, L. C., Barbosa, F. R., Fiuza, P. O., Divakar, P. K., Shenoy, B. D., Castaneda-Ruiz, R. F., Somrithipol, S., Lateef, A. A., Karunarathna, S. C., Tibpromma, S., Mortimer, P. E., Wanasinghe, D. N., Phookamsak, R., Xu, J., Wang, Y., Tian, F., Alvarado, P., Li, D. W., Kusan, I, Matocec, N., Mesic, A., Tkalcec, Z., Maharachchikumbura, S. S. N., Papizadeh, M., Heredia, G., Wartchow, F., Bakhshi, M., Boehm, E., Youssef, N., Hustad, V. P., Lawrey, J. D., Santiago, A. L. C. M. A., Bezerra, J. D. P., Souza-Motta, C. M., Firmino, A. L., Tian, Q., Houbraken, J., Hongsanan, S., Tanaka, K., Dissanayake, A. J., Monteiro, J. S., Grossart, H. P., Suija, A., Weerakoon, G., Etayo, J., Tsurykau, A., Vazquez, V., Mungai, P., Damm, U., Li, Q. R., Zhang, H., Boonmee, S., Lu, Y. Z., Becerra, A. G., Kendrick, B., Brearley, F. Q., Motiejunaite, J., Sharma, B., Khare, R., Gaikwad, S., Wijesundara, D. S. A., Tang, L. Z., He, M. Q., Flakus, A., Rodriguez-Flakus, P., Zhurbenko, M. P., McKenzie, E. H. C., Stadler, M., Bhat, D. J., Liu, J. K., Raza, M., Jeewon, R., Nassonova, E. S., Prieto, M., Jayalal, R. G. U., Erdogdu, M., Yurkov, A., Schnittler, M., Shchepin, O. N., Novozhilov, Y. K., Silva-Filho, A. G. S., Gentekaki, E., Liu, P., Cavender, J. C., Kang, Y., Mohammad, S., Zhang, L. F., Xu, R. F., Li, Y. M., Dayarathne, M. C., Ekanayaka, A. H., Wen, T. C., Deng, C. Y., Pereira, O. L., Navathe, S., Hawksworth, D. L., Fan, X. L., Dissanayake, L. S., Kuhnert, E., and Thines, M.

Published
2020

173. 25 Years of psychological research investigating disordered eating in people with diabetes: What have we learnt?

Author

Broadley, M. M., Zaremba, N., Andrew, B., Ismail, K., Treasure, J., White, M. J., Stadler, M., Broadley, M. M., Zaremba, N., Andrew, B., Ismail, K., Treasure, J., White, M. J., and Stadler, M.

Abstract

Disordered eating is a serious and under-recognized problem in people with diabetes. This narrative review summarizes the research contributions made by psychological science over the past 25 years to the study of disordered eating in people with type 1 or type 2 diabetes, and identifies gaps and future directions relevant to both healthcare professionals and researchers. Key focus areas of psychological research investigating disordered eating in people with diabetes have been: (1) defining and classifying types of disordered eating; (2) identifying demographic, diabetes-specific and psychosocial correlates of disordered eating, and developing theoretical models of disordered eating in people with type 1 diabetes; (3) identifying the physical and psychosocial consequences of disordered eating; and (4) developing screening measures to identify disordered eating in people with type 1 diabetes. Psychological science has made significant contributions over the past 25 years to our understanding of the nature of this problem and the multiple factors which may interrelate with disordered eating in people with diabetes. Key areas for further attention include: (1) a better definition of disordered eating subtypes in people with type 1 diabetes; (2) characterizing disordered eating in people with type 2 diabetes; and (3) developing multidisciplinary, evidence-based prevention and treatment interventions for comorbid disordered eating and diabetes.

Published
2020

175. Introduction

Author

Dommann, Monika, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), Dommann, Monika, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), and Stadler, M ( Max )

Published
2020

176. Taxonomic and phylogenetic contributions to fungi associated with the invasive weed Chromolaena odorata (Siam weed)

Author

Mapook, Ausana, Hyde, K.D., McKenzie, E.H.C., Jones, E.B.G., Bhat, D.J., Jeewon, R., Stadler, M., Samarakoon, M.C., Malaithong, Maitree, Tanunchai, Benjawan, Buscot, Francois, Wubet, Tesfaye, Purahong, Witoon, Mapook, Ausana, Hyde, K.D., McKenzie, E.H.C., Jones, E.B.G., Bhat, D.J., Jeewon, R., Stadler, M., Samarakoon, M.C., Malaithong, Maitree, Tanunchai, Benjawan, Buscot, Francois, Wubet, Tesfaye, and Purahong, Witoon

Abstract

This article provides morphological descriptions and illustrations of microfungi associated with the invasive weed, Chromolaena odorata, which were mainly collected in northern Thailand. Seventy-seven taxa distributed in ten orders, 23 families (of which Neomassarinaceae is new), 12 new genera (Chromolaenicola, Chromolaenomyces, Longiappendispora, Pseudocapulatispora, Murichromolaenicola, Neoophiobolus, Paraleptospora, Pseudoroussoella, Pseudostaurosphaeria, Pseudothyridariella, Setoarthopyrenia, Xenoroussoella), 47 new species (Aplosporella chromolaenae, Arthrinium chromolaenae, Chromolaenicola chiangraiensis, C. lampangensis, C. nanensis, C. thailandensis, Chromolaenomyces appendiculatus, Diaporthe chromolaenae, Didymella chromolaenae, Dyfrolomyces chromolaenae, Leptospora chromolaenae, L. phraeana, Longiappendispora chromolaenae, Memnoniella chromolaenae, Montagnula chiangraiensis, M. chromolaenae, M. chromolaenicola, M. thailandica, Murichromolaenicola chiangraiensis, M. chromolaenae, Muyocopron chromolaenae, M. chromolaenicola, Neomassarina chromolaenae, Neoophiobolus chromolaenae, Neopyrenochaeta chiangraiensis, N. chromolaenae, N. thailandica, N. triseptatispora, Nigrograna chromolaenae, Nothophoma chromolaenae, Paraleptospora chromolaenae, P. chromolaenicola, Patellaria chromolaenae, Pseudocapulatispora longiappendiculata, Pseudoroussoella chromolaenae, Pseudostaurosphaeria chromolaenae, P. chromolaenicola, Pseudothyridariella chromolaenae, Pyrenochaetopsis chromolaenae, Rhytidhysteron chromolaenae, Setoarthopyrenia chromolaenae, Sphaeropsis chromolaenicola, Tremateia chiangraiensis, T. chromolaenae, T. thailandensis, Xenoroussoella triseptata, Yunnanensis chromolaenae), 12 new host records, three new taxonomic combinations (Chromolaenicola siamensis, Pseudoroussoella elaeicola, Pseudothyridariella mahakashae), and two reference specimens (Torula chromolaenae, T. fici) are described and illustrated. Unlike some other hosts, e.g. bamboo (Poaceae) and Pandanac

Published
2020

177. Computing aliens: from central control migration scenarios

Author

Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), Espahangizi, Kijan, Mähr, Moritz, Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), Espahangizi, Kijan, and Mähr, Moritz

Published
2020

178. Delete information: sanitize, shred, and burn

Author

Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), Deboni, Sascha, Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), and Deboni, Sascha

Published
2020

179. Rückbesinnung als Gegen|Wissen?

Author

Rhyner, Niki, Güttler, Nils, Stadler, Max, Rhyner, N ( Niki ), Güttler, N ( Nils ), Stadler, M ( Max ), Samida, Stefanie; https://orcid.org/0000-0003-2243-331X, Rhyner, Niki, Güttler, Nils, Stadler, Max, Rhyner, N ( Niki ), Güttler, N ( Nils ), Stadler, M ( Max ), and Samida, Stefanie; https://orcid.org/0000-0003-2243-331X

Published
2020

180. Zug: crypto valley after Vitalik Buterin

Author

Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), and Stadler, M ( Max )

Published
2020

181. Gondo: white gold, crypto gold: alpine hydropolitics

Author

Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), and Stadler, M ( Max )

Published
2020

182. Introduction

Author

Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), Stadler, M ( Max ), Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rickli, Hannes, Stadler, Max, Dommann, M ( Monika ), Rickli, H ( Hannes ), and Stadler, M ( Max )

Published
2020

184. „Do artefacts have politics?“: Replik: Beton

Author

Rhyner, Niki, Güttler, Nils, Stadler, Max, Rhyner, N ( Niki ), Güttler, N ( Nils ), Stadler, M ( Max ), Dommann, Monika; https://orcid.org/0009-0006-6289-6430, Rhyner, Niki, Güttler, Nils, Stadler, Max, Rhyner, N ( Niki ), Güttler, N ( Nils ), Stadler, M ( Max ), and Dommann, Monika; https://orcid.org/0009-0006-6289-6430

Published
2020

185. Seven new cytotoxic and antimicrobial xanthoquinodins from jugulospora vestita

Author

Universitat Rovira i Virgili, Shao L; Marin-Felix Y; Surup F; Stchigel AM; Stadler M, Universitat Rovira i Virgili, and Shao L; Marin-Felix Y; Surup F; Stchigel AM; Stadler M

Abstract

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. During the course of a screening for novel biologically active secondary metabolites produced by the Sordariomycetes (Ascomycota, Fungi), the ex-type strain of Jugulospora vestita was found to produce seven novel xanthone-anthraquinone heterodimers, xanthoquinodin A11 (1) and xanthoquinodins B10–15 (2–7), together with the already known compound xanthoquinodin B4 (8). The structures of the xanthoquinodins were determined by analysis of the nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric data. Moreover, the absolute configurations of these metabolites were established by analysis of the1H−1H coupling constants, nuclear Overhauser effect spectroscopy (NOESY) correlations, and Electronic Circular Dichroism (ECD) spectroscopic data. Antifungal and antibacterial activities as well as cytotoxicity of all compounds were tested. Xanthoquinodin B11 showed fungicidal activities against Mucor hiemalis [minimum inhibitory concentration (MIC) 2.1 µg/mL], Rhodotorula glutinis (MIC 2.1 µg/mL), and Pichia anomala (MIC 8.3 µg/mL). All the compounds 1–8 displayed anti-Gram-positive bacteria activity (MIC 0.2–8.3 µg/mL). In addition, all these eight compounds showed cytotoxicity against KB 3.1, L929, A549, SK-OV-3, PC-3, A431, and MCF-7 mammalian cell lines. The six novel compounds (1–3, 5–7), together with xanthoquinodin B4, were also found in the screening of other strains belonging to Jugulospora rotula, revealing the potential chemotaxonomic significance of the compound class for the genus.

Published
2020

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