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151. Single asperity tribochemical wear of silicon nitride studied by atomic force microscopy.

Author

Maw, W., Stevens, F., Langford, S. C., and Dickinson, J. T.

Subjects
*SILICON nitride, *ATOMIC force microscopy
Abstract

Nanometer scale single asperity tribochemical wear of silicon nitride was examined by measuring the wear of atomic force microscope tips translated against a variety of substrates in aqueous solutions. We show that the chemical nature of the substrate plays an important role: significant wear was observed only when the substrate surface is populated with appropriate metal-hydroxide bonds. Mica and calcite substrates, whose water-exposed cleavage surfaces lack these bonds, produced little if any tip wear. As a function of contact force F[SUBN] and scan duration t, the length of the tips in this work decreases approximately as (F[SUBN]t)[SUP0.5]. We propose that pressure-induced intermediate states involving hydroxyl groups form on both the tip and the substrate; chemical reactions subsequently form transient bridging chemical bonds that are responsible for tip wear. [ABSTRACT FROM AUTHOR]

Published
2002
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159. Tumorforschung I

Author

Steinhoff, H.-J., Clasen, B. P. E., Janssen, Th., Axhausen, M., Herold, M., Tausch-Treml, R., Reiman, V., Holtmann, S., Vogl, Th., Weber, H., Schroeder, H.-G., Kleinsasser, O., Wolf, J., Laskawi, R., Brauneis, J., Schröder, M., Göhde, W., Maier, H., Stevens, F. S., Weidauer, H., Altmannsberger, M., Kroschel, S., Mischke, D., Lörz, M., Metz, C., Wendler, E., Meyer-Breiting, E., Wustrow, T. P. U., Kabelitz, D., Welkoborsky, H. J., Sorger, K., Knuth, A., Wustrow, J., Hansmann, M.-L., Deitmer, T., Freytag, G., Swoboda, H., Neumann, H., Cartellieri, M., Matschke, R. G., Heilmann-Jedamzik, C., Jedamzik, J., Plath, P., Kumazawa, H., Koldovsky, P., Kürten, Ch., Vosteen, K.-H., Fleischer, Konrad, editor, and Wigand, Malte Erik, editor

Published
1988
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173. CHAPTERS IN THE PREHISTORY OF EASTERN ARIZONA, II

Author

MARTIN, PAUL S., RINALDO, JOHN B., LONGACRE, WILLIAM A., FREEMAN, LESLIE G., BROWN, JAMES A., HEVLY, RICHARD H., COOLEY, M. E., CUTLER, HUGH C., and SEABERG, STEVENS F. F.

Published
1964

174. ANNUAL BANQUET

Author

Root, Elihu, Stevens, F. C., Coolidge, Archibald C., and Bryan, William J.

Published
1914

181. Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression

Author

Sura Ali, Minyan Wang, Paul L. Chazot, Stevens F Duckett, and Tihomir P. Obrenovitch

Subjects
Pharmacology, Retina, medicine.drug_class, Depolarization, Retinal, Biology, Receptor antagonist, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Cerebral cortex, Cortical spreading depression, medicine, NMDA receptor, Receptor, Neuroscience
Abstract

BACKGROUND AND PURPOSE Spreading depression (SD) is a local, temporary disruption of cellular ionic homeostasis that propagates slowly across the cerebral cortex and other neural tissues such as the retina. Spreading depolarization associated with SD occurs in different types of stroke, and this phenomenon correlates also with the initiation of classical migraine aura. The aim of this study was to investigate how NMDA receptor antagonists with different subtype selectivity alter SD. EXPERIMENTAL APPROACH Immunoblotting was applied to the chick retina for NMDA receptor subunit protein analysis, and an efficient in vitro chick retinal model used with SD imaging for NMDA receptor pharmacology. KEY RESULTS The prominent NMDA receptor subtypes GluN1, GluN2A and GluN2B were found highly expressed in the chick retina. Nanomolar concentrations of NVP-AAM077 (GluN2A-preferring receptor antagonist) markedly suppressed high K+-induced SD; that is, ∼30 times more effectively than MK801. At sub-micromolar concentrations, Ro 25-6981 (GluN2B-preferring receptor antagonist) produced a moderate SD inhibition, whereas CP-101,606 (also GluN2B-preferring receptor antagonist) and UBP141 (GluN2C/2D-preferring receptor antagonist) had no effect. CONCLUSIONS AND IMPLICATIONS The expression of major NMDA receptor subtypes, GluN1, GluN2A and GluN2B in the chick retina makes them pertinent targets for pharmacological inhibition of SD. The high efficacy of NVP-AAM077 on SD inhibition suggests a critical role of GluN2A-containing receptors in SD genesis. Such high anti-SD potency suggests that NVP-AAM077, and other GluN2A-selective drug-like candidates, could be potential anti-migraine agents.

Published
2011
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182. STALK users guide

Author

Levine, D., primary, Facello, M., additional, Hallstrom, P., additional, Reeder, G., additional, Walenz, B., additional, and Stevens, F., additional

Published
1996
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183. STALK programmers guide

Author

Levine, D., primary, Hallstrom, P., additional, Reeder, G., additional, Walenz, B., additional, Stevens, F., additional, and Facello, M., additional

Published
1996
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184. Irish society of gastroenterology: Proceedings of winter meeting 1985 in gort muire conference centre, Ballinteer, Dublin on Friday 22nd and Saturday, 23rd November

Author

O’Byrne, P., Collins, P., Johnson, A., Ledwith, M., Lane, B., Bouchier-Hayes, D., MacMathuna, P., O’Reilly, T., Barry, M., Duanes-Laita, A., Feely, J., Keeling, P. W. N., Cotter, P., Burke, G., Waldron, R., Zinner, M. J., Jaffe, B. M., Givan, F., Keye, G., Byrne, P., O’Brien, M., O’Farrelly, Cliona, Stevens, F., McCarthy, C., Feighery, C., Weir, D. G., Hannigan, M. C., Stevens, F. M., McCarthy, C. F., Fottrell, P. F., O’Connor, M. P., Kennedy, N. P., Courtney, M. G., Kelleher, D., Weir, D. W., Senapati, A., Kitler, M. E., Thompson, R. P. H., O’Shea, B., Madigan, D., Keeling, P., Hennessy, T. P. J., Meenan, John J., Gaffney, Eoin F., Duigan, J. P., Johnson, A. H., Collins, P. B., Healy, M. V., Skehill, R., Grimes, H., O’Farrelly, C., Kelly, J., Rees, R., Hoey, H., Humphreys, H., Dooley, C., O’Leary, D., Bourke, S., McKenna, D., Power, B., Keane, C., Sweeney, E., O’Morain, C. A., Afdhal, N. H., McCormick, A., O’Donoghue, D. P., Quigley, E. M. M., Turnberg, L. A., Moorehead, R. J., Hoper, Margaret, McKelvey, S. T. D., Tobbia, I., Rafferty, R., Gillen, P., Stuart, R., Dawson, K., Collins, J. S. A., McKnigh, J. A., Pyper, P. C., Love, A. H. G., Dillon, M. E., O’Connor, E., Keeling, P. W. N., Broe, P. J., Harte, P. I., Keane, T., Garstin, W. I. H., Buchanan, K. D., Walsh, J. P., Bloomfield, F. J., Maxwell, W. J., Hogan, F. P., O’Malley, Vincent P., Postier, Russell G., Lombard, M., Craven, C., Spencer, S., Crowe, J., Quinn, Fergal, Templeton, John L., Tobin, M. V., Hughes, S., Gilmore, I T., Keane, R. M., Johnson, A. B., Duenas-Laita, A., Younger, K., O’Brien, T., Cotter, J., Cullinane, T., Whelton, M. J., Waldron, D., Bowes, K., Given, H. F., Gawley, W. F., Gorey, T. F., Osborne, D. H., Lane, B. E., Collins, P. G., Boston, V. E., and O’Mahony, C.

Published
1986
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185. Irish Society of Gastroenterology: Proceedings of the winter meeting of the irish society of gastroenterology, held in the royal college of surgeons

Author

McGee, D., Hurley, M. F., Shinkwin, M., Kirwan., W. O., Brady, H. R., O’Donoghue, D. P., Maxwell, R. J., Parks., T. G., Habba, S. F., Doyle, J. S., McCoy, G. F., Parks, T. G., Keane, F., Stephens, R., O’Connor, M., Byrne, P. J., Hennessy, T. P., Gallagher, C., Lennon, J., Crowe, J., O’Connell, D., Browne, Harold J., Legge, D., Kelleher, D., Bloomfield, J., Whelan, A., Weir, D., O’Donoghue, D. P., FitzGerald, O., Conalty, M. L., Courtney, D. F., Clanachan, A. S., Scott, G. W., Shattock, Alan G., McKeever, Una, Feighery, C., Weir, D., Cryan, E. M., Stevens, F. M., Fottrell, P. F., McNicholl, B., McCarthy, F., Arthurs, Yvonne, Doyle, G. D., Fielding, J. F., O’Grady, J. G., Stevens, F. M., Fottrell, P. F., McNicholl, B., O’Gorman, T. A., McCarthy, F., Sheahan, D. G., West, A. B., Stephens, R. B., Hennessy, T. P., McEntee, G., Gorey, T. F., Heffernan, S. J., Duignan, J. P., Duignan, J., Wesler, M., O’Higgins, N., O’Malley, E., MacLean, L. D., Watson, R. G. K., Devery, R., Collins, P. B., and Johnson, A. H.

Published
1982
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186. Irish Society of Gastroenterology: 21st anniversary year meeting, spring 1983

Author

Traynor, O. J., Byrne, P. J., Hennessy, T. P. J., O’Byrne, P., Given, F., Murphy, B., Regan, P., McDermott, S., Galvin, C., Flynn, J., Given, H. F., Harding, B., O’Grady, J., McMahon, H., McCarthy, C., Lennon, F., Kotwall, C., Baer, H. P., Clanachan, A. S., Scott, G. W., Duignan, J. P., McGovern, E., Power-Daly, M., Hone, R., Ashe, J., O’Malley, E., Powderly, W., Gallagher, C., Crowe, J. P., Ennis, J., Cahill, Jacqueline, McCarthy, C. F., O’Farrelly, Cliona, Whelan, C. A., Feighery, C. F., Weir, D. G., Devitt, M., Cunningham, B., Dobson, A., Headon, D. R., Stevens, F. M., O’Grady, J. G., O’Toole, G., Greally, J., Feighery, C., O’Gorman, T., Walshe, K., Speekenbrink, A. B. J., O’Moore, R. R., O’Callaghan, T. W., Wright, E., Lennon, J., Crowe, J., Wilson, Ian A. I., Delargy, M. A., O’Shaughnessy, Margaret, Tomkin, G. H., Watt, P. C. H., Spence, R. A. J., Campbell, R. C., McGurk, J. J., Whyte, D. G. C., Pyper, P. C., Parks, T. G., Collins, B. J., McFarland, R. J., Love, A. H. G., O’Flanagan, S., O’Connell, D., Gillen, P., O’Higgins, N., Ryan, Deirdre, Bourke, M., Stevens, F., Sloan, J. M., Donaldson, Joan D., Kennedy, T. L., Patterson, C. C., Salam, I. M. A., Doorly, T., Hegarty, J. H., Mullin, J. P. M, and Johnston, G. W.

Published
1985
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187. Irish Society of Gastroenterology Proceedings of the Summer Meeting of the Irish Society of Gastroenterology, held in Universitly College, Cork on Friday 6th and Saturday 7th June, 1986

Author

Moorehead, R. J., Donaldson, John, McKelvey, S. T. D., Drumm, J., Harding, L. K., Clarke, E. A., Alexander-Williams, J., Donovan, I. A., Lorigan, G., Butler, F., Broe, P. J., O’Hara, Martin J., McCormick, P. Aidan, Molloy, Aishling, McGrath, Derek, O’Donoghue, Diarmuid P., Farrell, T., O’Donoghue, D., Daly, L., Masterson, J. B., Breen, E. G., Coughlan, J., Connolly, C. E., Stevens, F. M., McCarthy, C. F., Tobin, M. V., Fiskan, R. A., Dissory, R. T., Gilmore, I. T., McCormick, Deirdre, Cullen, Alan, McCormick, P. Aidan, Towers, Robert P., Keane, R. M., Coleman, J. E., Clery, A. P., Keane, T., Dillon, B., Afdhal, N. H., McCormick, C. J., Stevens, F. M., Connolly, C. E., McCarthy, C. F., Hitchcock, H., Waldron, David J., Fitzgerald, Raymond J., Quigley, E. M. M., Hall, L., Turnberg, L. A., Brennan, F. N., Buchanan, K. D., Afdhal, N. H., Duffy, M. J., Thornton, A., O’Sullivan, F., O’Donoghue, D. P., Mullen, P., O’Connor, B., Lombard, M., Coakley, J. B., Crowe, J., Lennon, J. R., Keeling, P., Hennessy, T. P. J., Gleeson, D., Quereshi, Y., Murphy, G. M., Dowling, R. H., O’Connor, H. J., Dixon, M. F., Wyatt, J. I., Axon, A. T. R., Gillen, P., Keeling, P., Byrne, P. J., West, A. B., Hennessy, T. P. J., Walsh, T. N., O’Higgins, N., Quigley, E. M. M., Turnberg, L. A., O’Hara, Martin J., McCormick, P. Aidan, McGowan, Katherine, Miller, Joan C., Masterson, James, O’Donoghue, Diarmuid P., Courtney, M. G., McPartlin, J. M., Scott, J. M., Weir, D. G., Wilson, B. G., Howe, J. P., Parks, T. G., McCormick, P. A., Ramsay, N., Afdhal, N., Tubridy, P., Shattock, A. G., Hillery, I., O’Donoghue, D. P., Collins, J. S. A., Knill-Jones, R. P., Crean, G. P., Love, A. H. G., Quigley, E. M. M., Hole, D. J., Gillis, C. R., Watkinson, G., Moore, Helena, Moylan, H. E., Fottrell, P. F., Stevens, F. M., Brady, H. R., Godson, C., Ryan, M. P., Bourke, S., FitzGerald, M. X., McCormick, P. A., O’Farrelly, C., Graeme-Cook, F., Finch, A., Feighery, C., Weir, D. G., O’Donoghue, D. P., FitzGerald, M. X., Maxwell, W. J., Walsh, J. P., Hogan, F. P., Kennedy, N. P., Keeling, P. W. N., Sheil, O., Barniville, H., and Fitzgerald, O.

Published
1987
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190. S2. Novel Retinal Expression of Beaded Filament Structural Protein 2 Observed in the C57BL/6JOlaHsd Mouse

Author

Tam, Lawrence, Kiang, Anna-Sophia, Kennan, Avril, Humphries, Pete, Reynolds, Alison, Kenna, Paul F., Farrar, G. Jane, Marignol, L, Foley, R, Fairbairn, LJ, Southgate, TD, Worthington, J, Hollywood, D, Lawler, M, Brophy, K, Ryan, A, O'Morain, C, Kennedy, N, McLoughlin, R, Stevens, F, Feighery, C, Kelleher, D, McManus, R, Byrne, C, Logan, WP, Sweet, K, Smith, G, McConnell, V, Graham, CA, King, C, McDevitt, T, Rogers, M, O'hIci, B, McQuaid, S, Le Maréchal, C, Férec, C, Barton, DE, Parle-McDermott, Anne, Mills, James L, Molloy, Anne M, Carroll, Nicola, Kirke, Peadar N, Cox, Christopher, Conley, Mary R, Pangilinan, Faith J, Brody, Lawrence C, Scott, John M, Lau, Lilian PL, Bradley, Daniel G, Lynn, David J, Ryan, AW, Mattiangeli, V, Morris, DW, Daly, JS, McEvoy, Brian, Shriver, Mark D, Allen, Danny, Kenna, Paul F, Farrar, G Jane, Bittnerová, A, Kadlecová, J, Novotný, T, Gaillyová, R, Schmidtová, Z, Šišáková, M, Toman, O, Semrád, B, Kuglík, P, Carroll, N, Brody, LC, Mills, JL, Kirke, PN, Molloy, AM, Scott, JM, Parle-McDermott, A, Conant, EK, Berrar, DP, Bjourson, AJ, Downes, CS, Finn, Susan, Colreavy, M, Ann Lynch, Sally, Kee, Janice, Lambert, D, Barton, D, Lynch, SA, Laing, ME, Dicker, P, Moloney, FJ, Murphy, GM, Conlon, P, Whitehead, AS, Shields, DC, Lee, Cheng Hiang, Woods, Pauline, Magee, Alex, Logan, Amy, Dempsey, S, Kettle, P, McMullin, MF, Humpreys, Mervyn, Humphreys, Mervyn, Walker, L, Paterson, JS, Morrison, PJ, McCullough, Simon, Stewart, Fiona, McKee, Shane, Meng, Weihua, Patterson, Chris C, Belton, Christine, Kamaruddin, Shafie, Horan, Paul G, Spence, Mark S, McGlinchey, Paul G, McKeown, Pascal P, Ó'Dúshláine, Colm, Shields, Denis, Roche, S, Cassidy, F, Zhao, C, Badger, J, Claffey, E, Mooney, L, Delaney, C, Dobrin, S, McKeon, P, and Stewart, Fiona J

Subjects
Abstracts, Poster Presentation, Spoken Paper, Abstract
Published
2007

192. Aanvullende diagnostiek op Nederlandse huisartsenpost

Author

Schols, A.M.R., Stevens, F., Zeijen, C.G.I.P., Dinant, G.J., van Vugt, C., Cals, J.W.L., Family Medicine, Onderwijsontw & Onderwijsresearch, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R5 - Optimising Patient Care, RS: CAPHRI - R6 - Promoting Health & Personalised Care, and RS: SHE - R1 - Research (OvO)

Published
2015

200. Sneltesten in de huisartspraktijk

Author

Cals, J W L, Schols, A M R, van Weert, H C P M, Stevens, F, Zeijen, C G I P, Holtman, G, Lucassen, W A M, Berger, M Y, Damage and Repair in Cancer Development and Cancer Treatment - 1, and Life Course Epidemiology

Abstract

OBJECTIVE: To provide insight into the current use, future needs, and attitudes towards point-of-care testing among Dutch family practitioners. DESIGN: Cross-sectional online survey. METHOD: We performed a survey among 2129 Dutch family practitioners. We asked respondents to report on the current and desired use of point-of-care tests, frequency of use, their opinions on aspects of point-of-care tests and consequences of point-of-care tests on their practice, acceptable waiting times for test results to come in, the desire for point-of-care tests at out-of-hours services, and conditions for which a point-of-care test could assist in diagnosis. RESULTS: 639 family practitioners completed the survey (response rate: 30%). The most common point-of-care tests currently used by family physicians were: blood glucose (96%), urine leucocytes or nitrite (96%), urine pregnancy (94%), haemoglobin (58%), and CRP (48%). The most commonly desired point-of-care tests were: D-dimer (70%), troponin (65%), BNP (62%), chlamydia (60%), and INR (54%). Family practitioners expected point-of-care tests to have a positive effect on patient satisfaction (93%), diagnostic certainty (89%), antibiotics use (84%), and substitution to primary care (78%). They considered the proven effect on clinical management (46%) and the tests' reliability (35%) to be important aspects of point-of-care tests. Respondents wanted point-of-care tests to help them diagnose acute conditions, such as acute thromboembolic disorders (D-dimers), cardiac disorders (troponin, BNP), and infections (CRP, chlamydia). CONCLUSION: The current use of point-of-care testing in family practice is restricted to a limited number of tests. In the future, Dutch family practitioners wish to use more point-of-care tests, especially in acute conditions in which a diagnostic decision needs to be made immediately.

Published
2014

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