2,887 results on '"Stilgenbauer, Stephan"'
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152. Related Article from Immunoglobulin Heavy Chain Variable Gene Usage and (Super)-antigen Drive in Chronic Lymphocytic Leukemia
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Bühler, Andreas, primary, Zenz, Thorsten, primary, and Stilgenbauer, Stephan, primary
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- 2023
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153. Supplementary Data from Activation of Notch and Myc Signaling via B-cell–Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia
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Biran, Anat, primary, Yin, Shanye, primary, Kretzmer, Helene, primary, ten Hacken, Elisa, primary, Parvin, Salma, primary, Lucas, Fabienne, primary, Uduman, Mohamed, primary, Gutierrez, Catherine, primary, Dangle, Nathan, primary, Billington, Leah, primary, Regis, Fara Faye, primary, Rassenti, Laura Z., primary, Mohammad, Arman, primary, Hoffmann, Gabriela Brunsting, primary, Stevenson, Kristen, primary, Zheng, Mei, primary, Witten, Elizabeth, primary, Fernandes, Stacey M., primary, Tausch, Eugen, primary, Sun, Clare, primary, Stilgenbauer, Stephan, primary, Brown, Jennifer R., primary, Kipps, Thomas J., primary, Aster, John C., primary, Gnirke, Andreas, primary, Neuberg, Donna S., primary, Letai, Anthony, primary, Wang, Lili, primary, Carrasco, Ruben D., primary, Meissner, Alexander, primary, and Wu, Catherine J., primary
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- 2023
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154. Data from Activation of Notch and Myc Signaling via B-cell–Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia
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Biran, Anat, primary, Yin, Shanye, primary, Kretzmer, Helene, primary, ten Hacken, Elisa, primary, Parvin, Salma, primary, Lucas, Fabienne, primary, Uduman, Mohamed, primary, Gutierrez, Catherine, primary, Dangle, Nathan, primary, Billington, Leah, primary, Regis, Fara Faye, primary, Rassenti, Laura Z., primary, Mohammad, Arman, primary, Hoffmann, Gabriela Brunsting, primary, Stevenson, Kristen, primary, Zheng, Mei, primary, Witten, Elizabeth, primary, Fernandes, Stacey M., primary, Tausch, Eugen, primary, Sun, Clare, primary, Stilgenbauer, Stephan, primary, Brown, Jennifer R., primary, Kipps, Thomas J., primary, Aster, John C., primary, Gnirke, Andreas, primary, Neuberg, Donna S., primary, Letai, Anthony, primary, Wang, Lili, primary, Carrasco, Ruben D., primary, Meissner, Alexander, primary, and Wu, Catherine J., primary
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- 2023
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155. Supplementary Data from Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia
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Davids, Matthew S., primary, Hallek, Michael, primary, Wierda, William, primary, Roberts, Andrew W., primary, Stilgenbauer, Stephan, primary, Jones, Jeffrey A., primary, Gerecitano, John F., primary, Kim, Su Young, primary, Potluri, Jalaja, primary, Busman, Todd, primary, Best, Andrea, primary, Verdugo, Maria E., primary, Cerri, Elisa, primary, Desai, Monali, primary, Hillmen, Peter, primary, and Seymour, John F., primary
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- 2023
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156. Data from MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma
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Hüllein, Jennifer, primary, Słabicki, Mikołaj, primary, Rosolowski, Maciej, primary, Jethwa, Alexander, primary, Habringer, Stefan, primary, Tomska, Katarzyna, primary, Kurilov, Roma, primary, Lu, Junyan, primary, Scheinost, Sebastian, primary, Wagener, Rabea, primary, Huang, Zhiqin, primary, Lukas, Marina, primary, Yavorska, Olena, primary, Helfrich, Hanne, primary, Scholtysik, René, primary, Bonneau, Kyle, primary, Tedesco, Donato, primary, Küppers, Ralf, primary, Klapper, Wolfram, primary, Pott, Christiane, primary, Stilgenbauer, Stephan, primary, Burkhardt, Birgit, primary, Löffler, Markus, primary, Trümper, Lorenz H., primary, Hummel, Michael, primary, Brors, Benedikt, primary, Zapatka, Marc, primary, Siebert, Reiner, primary, Kreuz, Markus, primary, Keller, Ulrich, primary, Huber, Wolfgang, primary, and Zenz, Thorsten, primary
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- 2023
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157. Supplementary Figure Legends 1-8 from A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia
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Loeder, Sandra, primary, Zenz, Thorsten, primary, Schnaiter, Andrea, primary, Mertens, Daniel, primary, Winkler, Dirk, primary, Döhner, Hartmut, primary, Debatin, Klaus-Michael, primary, Stilgenbauer, Stephan, primary, and Fulda, Simone, primary
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- 2023
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158. Data from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
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Kovaleva, Valentina, primary, Mora, Rodrigo, primary, Park, Yoon Jung, primary, Plass, Christoph, primary, Chiramel, Abhilash I., primary, Bartenschlager, Ralf, primary, Döhner, Hartmut, primary, Stilgenbauer, Stephan, primary, Pscherer, Armin, primary, Lichter, Peter, primary, and Seiffert, Martina, primary
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- 2023
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159. Supplementary Table 2 from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
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Kovaleva, Valentina, primary, Mora, Rodrigo, primary, Park, Yoon Jung, primary, Plass, Christoph, primary, Chiramel, Abhilash I., primary, Bartenschlager, Ralf, primary, Döhner, Hartmut, primary, Stilgenbauer, Stephan, primary, Pscherer, Armin, primary, Lichter, Peter, primary, and Seiffert, Martina, primary
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- 2023
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160. Supplementary Figures 1-8 from A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia
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Loeder, Sandra, primary, Zenz, Thorsten, primary, Schnaiter, Andrea, primary, Mertens, Daniel, primary, Winkler, Dirk, primary, Döhner, Hartmut, primary, Debatin, Klaus-Michael, primary, Stilgenbauer, Stephan, primary, and Fulda, Simone, primary
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- 2023
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161. Supplementary Table 1 from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
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Kovaleva, Valentina, primary, Mora, Rodrigo, primary, Park, Yoon Jung, primary, Plass, Christoph, primary, Chiramel, Abhilash I., primary, Bartenschlager, Ralf, primary, Döhner, Hartmut, primary, Stilgenbauer, Stephan, primary, Pscherer, Armin, primary, Lichter, Peter, primary, and Seiffert, Martina, primary
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- 2023
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162. Supplementary Figure 2 from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
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Kovaleva, Valentina, primary, Mora, Rodrigo, primary, Park, Yoon Jung, primary, Plass, Christoph, primary, Chiramel, Abhilash I., primary, Bartenschlager, Ralf, primary, Döhner, Hartmut, primary, Stilgenbauer, Stephan, primary, Pscherer, Armin, primary, Lichter, Peter, primary, and Seiffert, Martina, primary
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- 2023
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163. Supplementary Figure 1 from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
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Kovaleva, Valentina, primary, Mora, Rodrigo, primary, Park, Yoon Jung, primary, Plass, Christoph, primary, Chiramel, Abhilash I., primary, Bartenschlager, Ralf, primary, Döhner, Hartmut, primary, Stilgenbauer, Stephan, primary, Pscherer, Armin, primary, Lichter, Peter, primary, and Seiffert, Martina, primary
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- 2023
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164. Supplementary Methods from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
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Kovaleva, Valentina, primary, Mora, Rodrigo, primary, Park, Yoon Jung, primary, Plass, Christoph, primary, Chiramel, Abhilash I., primary, Bartenschlager, Ralf, primary, Döhner, Hartmut, primary, Stilgenbauer, Stephan, primary, Pscherer, Armin, primary, Lichter, Peter, primary, and Seiffert, Martina, primary
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- 2023
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165. Simultaneous Inhibition of PI3Kgamma and PI3Kdelta Deteriorates T-cell Function With Implications for Chronic Lymphocytic Leukemia
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Faehling, Sebastian, primary, Coelho, Mariana, additional, Floerchinger, Alessia, additional, Schneider, Christof, additional, Stilgenbauer, Stephan, additional, Lichter, Peter, additional, Seiffert, Martina, additional, and Roessner, Philipp M., additional
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- 2023
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166. Profile of the Multicenter Cohort of the German Cancer Consortium’s Clinical Communication Platform
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Maier, Daniel, primary, Vehreschild, Jörg Janne, additional, Uhl, Barbara, additional, Meyer, Sandra, additional, Berger-Thürmel, Karin, additional, Boerries, Melanie, additional, Braren, Rikmer, additional, Grünwald, Viktor, additional, Hadaschik, Boris, additional, Palm, Stefan, additional, Singer, Susanne, additional, Stuschke, Martin, additional, Juárez, David, additional, Delpy, Pierre, additional, Lambarki, Mohammed, additional, Hummel, Michael, additional, Engels, Cäcilia, additional, Andreas, Stefanie, additional, Gökbuget, Nicola, additional, Ihrig, Kristina, additional, Burock, Susen, additional, Keune, Dietmar, additional, Eggert, Angelika, additional, Keilholz, Ulrich, additional, Schulz, Hagen, additional, Büttner, Daniel, additional, Löck, Steffen, additional, Krause, Mechthild, additional, Esins, Mirko, additional, Ressing, Frank, additional, Schuler, Martin, additional, Brandts, Christian, additional, Brucker, Daniel P, additional, Husmann, Gabriele, additional, Oellerich, Thomas, additional, Metzger, Patrick, additional, Voigt, Frederik, additional, Illert, Anna L, additional, Theobald, Matthias, additional, Kindler, Thomas, additional, Sudhof, Ursula, additional, Reckmann, Achim, additional, Schwinghammer, Felx, additional, Nasseh, Daniel, additional, Weichert, Wilko, additional, von Bergwelt-Baildon, Michael, additional, Bitzer, Michael, additional, Malek, Nisar, additional, Öner, Öznur, additional, Schulze-Osthoff, Klaus, additional, Bartels, Stefan, additional, Haier, Jörg, additional, Ammann, Raimund, additional, Schmidt, Anja Franziska, additional, Guenther, Bernd, additional, Janning, Melanie, additional, Kasper, Bernd, additional, Loges, Sonja, additional, Stilgenbauer, Stephan, additional, Kuhn, Peter, additional, Tausch, Eugen, additional, Runow, Silvana, additional, Kerscher, Alexander, additional, Neumann, Michael, additional, Breu, Martin, additional, Lablans, Martin, additional, and Serve, Hubert, additional
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- 2023
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167. Molecular Cytogenetic Delineation of a Novel Critical Genomic Region in Chromosome Bands 11q22.3-923.1 in Lymphoproliferative Disorders
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Stilgenbauer, Stephan, Liebisch, Peter, James, Michael R., Schröder, Martin, Schlegelberger, Brigitte, Fischer, Konstanze, Bentz, Martin, Lichter, Peter, and Döhner, Hartmut
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- 1996
168. Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network
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Hermine, Olivier, Hoster, Eva, Walewski, Jan, Bosly, André, Stilgenbauer, Stephan, Thieblemont, Catherine, Szymczyk, Michal, Bouabdallah, Reda, Kneba, Michael, Hallek, Michael, Salles, Gilles, Feugier, Pierre, Ribrag, Vincent, Birkmann, Josef, Forstpointner, Roswitha, Haioun, Corinne, Hänel, Mathias, Casasnovas, René Olivier, Finke, Jürgen, Peter, Norma, Bouabdallah, Kamal, Sebban, Catherine, Fischer, Thomas, Dührsen, Ulrich, Metzner, Bernd, Maschmeyer, Georg, Kanz, Lothar, Schmidt, Christian, Delarue, Richard, Brousse, Nicole, Klapper, Wolfram, Macintyre, Elizabeth, Delfau-Larue, Marie-Hélène, Pott, Christiane, Hiddemann, Wolfgang, Unterhalt, Michael, and Dreyling, Martin
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- 2016
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169. High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial
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Illerhaus, Gerald, Kasenda, Benjamin, Ihorst, Gabriele, Egerer, Gerlinde, Lamprecht, Monika, Keller, Ulrich, Wolf, Hans-Heinrich, Hirt, Carsten, Stilgenbauer, Stephan, Binder, Mascha, Hau, Peter, Edinger, Matthias, Frickhofen, Norbert, Bentz, Martin, Möhle, Robert, Röth, Alexander, Pfreundschuh, Michael, von Baumgarten, Louisa, Deckert, Martina, Hader, Claudia, Fricker, Heidi, Valk, Elke, Schorb, Elisabeth, Fritsch, Kristina, and Finke, Jürgen
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- 2016
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170. Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy
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Herling, Carmen Diana, Klaumünzer, Marion, Rocha, Cristiano Krings, Altmüller, Janine, Thiele, Holger, Bahlo, Jasmin, Kluth, Sandra, Crispatzu, Giuliano, Herling, Marco, Schiller, Joanna, Engelke, Anja, Tausch, Eugen, Döhner, Hartmut, Fischer, Kirsten, Goede, Valentin, Nürnberg, Peter, Reinhardt, Hans Christian, Stilgenbauer, Stephan, Hallek, Michael, and Kreuzer, Karl-Anton
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- 2016
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171. First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): an international, open-label, randomised, phase 3, non-inferiority trial
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Eichhorst, Barbara, Fink, Anna-Maria, Bahlo, Jasmin, Busch, Raymonde, Kovacs, Gabor, Maurer, Christian, Lange, Elisabeth, Köppler, Hubert, Kiehl, Michael, Sökler, Martin, Schlag, Rudolf, Vehling-Kaiser, Ursula, Köchling, Georg, Plöger, Christoph, Gregor, Michael, Plesner, Torben, Trneny, Marek, Fischer, Kirsten, Döhner, Harmut, Kneba, Michael, Wendtner, Clemens-Martin, Klapper, Wolfram, Kreuzer, Karl-Anton, Stilgenbauer, Stephan, Böttcher, Sebastian, and Hallek, Michael
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- 2016
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172. Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study
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Stilgenbauer, Stephan, Eichhorst, Barbara, Schetelig, Johannes, Coutre, Steven, Seymour, John F, Munir, Talha, Puvvada, Soham D, Wendtner, Clemens-Martin, Roberts, Andrew W, Jurczak, Wojciech, Mulligan, Stephen P, Böttcher, Sebastian, Mobasher, Mehrdad, Zhu, Ming, Desai, Monali, Chyla, Brenda, Verdugo, Maria, Enschede, Sari Heitner, Cerri, Elisa, Humerickhouse, Rod, Gordon, Gary, Hallek, Michael, and Wierda, William G
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- 2016
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173. Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial
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Ferreri, Andrés J M, Cwynarski, Kate, Pulczynski, Elisa, Ponzoni, Maurilio, Deckert, Martina, Politi, Letterio S, Torri, Valter, Fox, Christopher P, Rosée, Paul La, Schorb, Elisabeth, Ambrosetti, Achille, Roth, Alexander, Hemmaway, Claire, Ferrari, Angela, Linton, Kim M, Rudà, Roberta, Binder, Mascha, Pukrop, Tobias, Balzarotti, Monica, Fabbri, Alberto, Johnson, Peter, Gørløv, Jette Sønderskov, Hess, Georg, Panse, Jens, Pisani, Francesco, Tucci, Alessandra, Stilgenbauer, Stephan, Hertenstein, Bernd, Keller, Ulrich, Krause, Stefan W, Levis, Alessandro, Schmoll, Hans J, Cavalli, Franco, Finke, Jürgen, Reni, Michele, Zucca, Emanuele, and Illerhaus, Gerald
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- 2016
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174. Postibrutinib outcomes in patients with mantle cell lymphoma
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Martin, Peter, Maddocks, Kami, Leonard, John P., Ruan, Jia, Goy, Andre, Wagner-Johnston, Nina, Rule, Simon, Advani, Ranjana, Iberri, David, Phillips, Tycel, Spurgeon, Stephen, Kozin, Eliana, Noto, Katherine, Chen, Zhengming, Jurczak, Wojciech, Auer, Rebecca, Chmielowska, Ewa, Stilgenbauer, Stephan, Bloehdorn, Johannes, Portell, Craig, Williams, Michael E., Dreyling, Martin, Barr, Paul M., Chen-Kiang, Selina, DiLiberto, Maurizio, Furman, Richard R., and Blum, Kristie A.
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- 2016
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175. Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial
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Fischer, Kirsten, Bahlo, Jasmin, Fink, Anna Maria, Goede, Valentin, Herling, Carmen Diana, Cramer, Paula, Langerbeins, Petra, von Tresckow, Julia, Engelke, Anja, Maurer, Christian, Kovacs, Gabor, Herling, Marco, Tausch, Eugen, Kreuzer, Karl-Anton, Eichhorst, Barbara, Böttcher, Sebastian, Seymour, John F., Ghia, Paolo, Marlton, Paula, Kneba, Michael, Wendtner, Clemens-Martin, Döhner, Hartmut, Stilgenbauer, Stephan, and Hallek, Michael
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- 2016
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176. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
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Jiao, Wei, Atwal, Gurnit, Polak, Paz, Karlic, Rosa, Cuppen, Edwin, Al-Shahrour, Fatima, Bailey, Peter J, Biankin, Andrew V, Boutros, Paul C, Campbell, Peter J, Chang, David K, Cooke, Susanna L, Deshpande, Vikram, Faltas, Bishoy M, Faquin, William C, Garraway, Levi, Getz, Gad, Grimmond, Sean M, Haider, Syed, Hoadley, Katherine A, Kaiser, Vera B, Kato, Mamoru, Kübler, Kirsten, Lazar, Alexander J, Li, Constance H, Louis, David N, Margolin, Adam, Martin, Sancha, Nahal-Bose, Hardeep K, Nielsen, G Petur, Nik-Zainal, Serena, Omberg, Larsson, P’ng, Christine, Perry, Marc D, Rheinbay, Esther, Rubin, Mark A, Semple, Colin A, Sgroi, Dennis C, Shibata, Tatsuhiro, Siebert, Reiner, Smith, Jaclyn, Stein, Lincoln D, Stobbe, Miranda D, Sun, Ren X, Thai, Kevin, Wright, Derek W, Wu, Chin-Lee, Yuan, Ke, Zhang, Junjun, Danyi, Alexandra, de Ridder, Jeroen, van Herpen, Carla, Lolkema, Martijn P, Steeghs, Neeltje, Morris, Quaid D, Aaltonen, Lauri A, Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J, Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C, Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B, Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G, Amary, Fernanda, Amin, Samirkumar B, Aminou, Brice, Ammerpohl, Ole, Anderson, Matthew J, Ang, Yeng, Antonello, Davide, Anur, Pavana, Aparicio, Samuel, Appelbaum, Elizabeth L, Arai, Yasuhito, Aretz, Axel, Arihiro, Koji, Ariizumi, Shun-ichi, Armenia, Joshua, Arnould, Laurent, Asa, Sylvia, Assenov, Yassen, Aukema, Sietse, Auman, J Todd, Aure, Miriam RR, Awadalla, Philip, Aymerich, Marta, Bader, Gary D, Baez-Ortega, Adrian, Bailey, Matthew H, Balasundaram, Miruna, Balu, Saianand, Bandopadhayay, Pratiti, Banks, Rosamonde E, Barbi, Stefano, Barbour, Andrew P, Barenboim, Jonathan, Barnholtz-Sloan, Jill, Barr, Hugh, Barrera, Elisabet, Bartlett, John, Bartolome, Javier, Bassi, Claudio, Bathe, Oliver F, Baumhoer, Daniel, Bavi, Prashant, Baylin, Stephen B, Bazant, Wojciech, Beardsmore, Duncan, Beck, Timothy A, Behjati, Sam, Behren, Andreas, Niu, Beifang, Bell, Cindy, Beltran, Sergi, Benz, Christopher, Berchuck, Andrew, Bergmann, Anke K, Bergstrom, Erik N, Berman, Benjamin P, Berney, Daniel M, Bernhart, Stephan H, Beroukhim, Rameen, Berrios, Mario, Bersani, Samantha, Bertl, Johanna, Betancourt, Miguel, Bhandari, Vinayak, Bhosle, Shriram G, Bieg, Matthias, Bigner, Darell, Binder, Hans, Birney, Ewan, Birrer, Michael, Biswas, Nidhan K, Bjerkehagen, Bodil, Bodenheimer, Tom, Boice, Lori, Bonizzato, Giada, De Bono, Johann S, Boot, Arnoud, Bootwalla, Moiz S, Borg, Ake, Borkhardt, Arndt, Boroevich, Keith A, Borozan, Ivan, Borst, Christoph, Bosenberg, Marcus, Bosio, Mattia, Boultwood, Jacqueline, Bourque, Guillaume, Bova, G Steven, Bowen, David T, Bowlby, Reanne, Bowtell, David DL, Boyault, Sandrine, Boyce, Rich, Boyd, Jeffrey, Brazma, Alvis, Brennan, Paul, Brewer, Daniel S, Brinkman, Arie B, Bristow, Robert G, Broaddus, Russell R, Brock, Jane E, Brock, Malcolm, Broeks, Annegien, Brooks, Angela N, Brooks, Denise, Brors, Benedikt, Brunak, Søren, Bruxner, Timothy JC, Bruzos, Alicia L, Buchanan, Alex, Buchhalter, Ivo, Buchholz, Christiane, Bullman, Susan, Burke, Hazel, Burkhardt, Birgit, Burns, Kathleen H, Busanovich, John, Bustamante, Carlos D, Butler, Adam P, Butte, Atul J, Byrne, Niall J, Børresen-Dale, Anne-Lise, Caesar-Johnson, Samantha J, Cafferkey, Andy, Cahill, Declan, Calabrese, Claudia, Caldas, Carlos, Calvo, Fabien, Camacho, Niedzica, Campo, Elias, Cantù, Cinzia, Cao, Shaolong, Carey, Thomas E, Carlevaro-Fita, Joana, Carlsen, Rebecca, Cataldo, Ivana, Cazzola, Mario, Cebon, Jonathan, Cerfolio, Robert, Chadwick, Dianne E, Chakravarty, Dimple, Chalmers, Don, Chan, Calvin Wing Yiu, Chan, Kin, Chan-Seng-Yue, Michelle, Chandan, Vishal S, Chanock, Stephen J, Chantrill, Lorraine A, Chateigner, Aurélien, Chatterjee, Nilanjan, Chayama, Kazuaki, Chen, Hsiao-Wei, Chen, Jieming, Chen, Ken, Chen, Yiwen, Chen, Zhaohong, Cherniack, Andrew D, Chien, Jeremy, Chiew, Yoke-Eng, Chin, Suet-Feung, Cho, Juok, Cho, Sunghoon, Choi, Jung Kyoon, Choi, Wan, Chomienne, Christine, Chong, Zechen, Choo, Su Pin, Chou, Angela, Christ, Angelika N, Christie, Elizabeth L, Chuah, Eric, Cibulskis, Carrie, Cibulskis, Kristian, Cingarlini, Sara, Clapham, Peter, Claviez, Alexander, Cleary, Sean, Cloonan, Nicole, Cmero, Marek, Collins, Colin C, Connor, Ashton A, Cooper, Colin S, Cope, Leslie, Corbo, Vincenzo, Cordes, Matthew G, Cordner, Stephen M, Cortés-Ciriano, Isidro, Covington, Kyle, Cowin, Prue A, Craft, Brian, Craft, David, Creighton, Chad J, Cun, Yupeng, Curley, Erin, Cutcutache, Ioana, Czajka, Karolina, Czerniak, Bogdan, Dagg, Rebecca A, Danilova, Ludmila, Davi, Maria Vittoria, Davidson, Natalie R, Davies, Helen, Davis, Ian J, Davis-Dusenbery, Brandi N, Dawson, Kevin J, De La Vega, Francisco M, De Paoli-Iseppi, Ricardo, Defreitas, Timothy, Dei Tos, Angelo P, Delaneau, Olivier, Demchok, John A, Demeulemeester, Jonas, Demidov, German M, Demircioğlu, Deniz, Dennis, Nening M, Denroche, Robert E, Dentro, Stefan C, Desai, Nikita, Deshwar, Amit G, Desmedt, Christine, Deu-Pons, Jordi, Dhalla, Noreen, Dhani, Neesha C, Dhingra, Priyanka, Dhir, Rajiv, DiBiase, Anthony, Diamanti, Klev, Ding, Li, Ding, Shuai, Dinh, Huy Q, Dirix, Luc, Doddapaneni, HarshaVardhan, Donmez, Nilgun, Dow, Michelle T, Drapkin, Ronny, Drechsel, Oliver, Drews, Ruben M, Serge, Serge, Dudderidge, Tim, Dueso-Barroso, Ana, Dunford, Andrew J, Dunn, Michael, Dursi, Lewis Jonathan, Duthie, Fraser R, Dutton-Regester, Ken, Eagles, Jenna, Easton, Douglas F, Edmonds, Stuart, Edwards, Paul A, Edwards, Sandra E, Eeles, Rosalind A, Ehinger, Anna, Eils, Juergen, Eils, Roland, El-Naggar, Adel, Eldridge, Matthew, Ellrott, Kyle, Erkek, Serap, Escaramis, Georgia, Espiritu, Shadrielle MG, Estivill, Xavier, Etemadmoghadam, Dariush, Eyfjord, Jorunn E, Fan, Daiming, Fan, Yu, Farcas, Claudiu, Fassan, Matteo, Fatima, Aquila, Favero, Francesco, Fayzullaev, Nodirjon, Felau, Ina, Fereday, Sian, Ferguson, Martin L, Ferretti, Vincent, Feuerbach, Lars, Field, Matthew A, Fink, J Lynn, Finocchiaro, Gaetano, Fisher, Cyril, Fittall, Matthew W, Fitzgerald, Anna, Fitzgerald, Rebecca C, Flanagan, Adrienne M, Fleshner, Neil E, Flicek, Paul, Foekens, John A, Fong, Kwun M, Fonseca, Nuno A, Foster, Christopher S, Fox, Natalie S, Fraser, Michael, Frazer, Scott, Frenkel-Morgenstern, Milana, Friedman, William, Frigola, Joan, Fronick, Catrina C, Fujimoto, Akihiro, Fujita, Masashi, Fukayama, Masashi, Fulton, Lucinda A, Fulton, Robert S, Furuta, Mayuko, Futreal, P Andrew, Füllgrabe, Anja, Gabriel, Stacey B, Gallinger, Steven, Gambacorti-Passerini, Carlo, Gao, Jianjiong, Gao, Shengjie, Garred, Øystein, Garrison, Erik, Garsed, Dale W, Gehlenborg, Nils, Gelpi, Josep LL, George, Joshy, Gerhard, Daniela S, Gerhauser, Clarissa, Gershenwald, Jeffrey E, Gerstein, Mark, Gerstung, Moritz, Ghori, Mohammed, Ghossein, Ronald, Giama, Nasra H, Gibbs, 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Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
- Published
- 2023
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177. Combined burden and functional impact tests for cancer driver discovery using DriverPower
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower’s background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery.
- Published
- 2023
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178. Integrative pathway enrichment analysis of multivariate omics data
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Paczkowska, Marta, Barenboim, Jonathan, Sintupisut, Nardnisa, Fox, Natalie S, Zhu, Helen, Abd-Rabbo, Diala, Mee, Miles W, Boutros, Paul C, Abascal, Federico, Amin, Samirkumar B, Bader, Gary D, Beroukhim, Rameen, Bertl, Johanna, Boroevich, Keith A, Brunak, Søren, Campbell, Peter J, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Chen, Ken, Choi, Jung Kyoon, Deu-Pons, Jordi, Dhingra, Priyanka, Diamanti, Klev, Feuerbach, Lars, Fink, J Lynn, Fonseca, Nuno A, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W, Gerstein, Mark, Getz, Gad, Gonzalez-Perez, Abel, Guo, Qianyun, Gut, Ivo G, Haan, David, Hamilton, Mark P, Haradhvala, Nicholas J, Harmanci, Arif O, Helmy, Mohamed, Herrmann, Carl, Hess, Julian M, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Hornshøj, Henrik, Isaev, Keren, Izarzugaza, Jose MG, Johnson, Rory, Johnson, Todd A, Juul, Malene, Juul, Randi Istrup, Kahles, Andre, Kahraman, Abdullah, Kellis, Manolis, Khurana, Ekta, Kim, Jaegil, Kim, Jong K, Kim, 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Vijver, Marc J, and Veer, L van’t
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.
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- 2023
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179. Pathway and network analysis of more than 2500 whole cancer genomes
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. While few non-coding genomic elements are recurrently mutated in this cohort, we identify 93 genes harboring non-coding mutations that cluster into several modules of interacting proteins. Among these are promoter mutations associated with reduced mRNA expression in TP53, TLE4, and TCF4. We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatures as samples with coding mutations in these genes. These analyses contribute a new repertoire of possible cancer genes and mechanisms that are altered by non-coding mutations and offer insights into additional cancer vulnerabilities that can be investigated for potential therapeutic treatments.
- Published
- 2023
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180. Divergent mutational processes distinguish hypoxic and normoxic tumours
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer.
- Published
- 2023
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181. Genomic footprints of activated telomere maintenance mechanisms in cancer
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Sieverling, Lina, Hong, Chen, Koser, Sandra D, Ginsbach, Philip, Kleinheinz, Kortine, Hutter, Barbara, Braun, Delia M, Cortés-Ciriano, Isidro, Xi, Ruibin, Kabbe, Rolf, Park, Peter J, Eils, Roland, Schlesner, Matthias, Akdemir, Kadir C, Alvarez, Eva G, Baez-Ortega, Adrian, Beroukhim, Rameen, Boutros, Paul C, Bowtell, David DL, Brors, Benedikt, Burns, Kathleen H, Campbell, Peter J, Chan, Kin, Chen, Ken, Dueso-Barroso, Ana, Dunford, Andrew J, Edwards, Paul A, Estivill, Xavier, Etemadmoghadam, Dariush, Feuerbach, Lars, Fink, J Lynn, Frenkel-Morgenstern, Milana, Garsed, Dale W, Gerstein, Mark, Gordenin, Dmitry A, Haan, David, Haber, James E, Hess, Julian M, Imielinski, Marcin, Jones, David TW, Ju, Young Seok, Kazanov, Marat D, Klimczak, Leszek J, Koh, Youngil, Korbel, Jan O, Kumar, Kiran, Lee, Eunjung Alice, Lee, Jake June-Koo, Li, Yilong, Lynch, Andy G, Macintyre, Geoff, Markowetz, Florian, Martincorena, Iñigo, Martinez-Fundichely, Alexander, Meyerson, Matthew, Miyano, Satoru, Nakagawa, 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Staaf, Johan, Stadler, Peter F, Staib, Peter, Stark, Stefan G, Stebbings, Lucy, Stefánsson, Ólafur Andri, Stegle, Oliver, Stein, Lincoln D, Stenhouse, Alasdair, Stilgenbauer, Stephan, Stobbe, Miranda D, Stratton, Michael R, Stretch, Jonathan R, Struck, Adam J, Stuart, Joshua M, Stunnenberg, Henk G, Su, Hong, Su, Xiaoping, Sun, Ren X, Sungalee, Stephanie, Susak, Hana, Suzuki, Akihiro, Sweep, Fred, Szczepanowski, Monika, Sültmann, Holger, Yugawa, Takashi, Tam, Angela, Tamborero, David, Tan, Benita Kiat Tee, Tan, Donghui, Tan, Patrick, Tanaka, Hiroko, Taniguchi, Hirokazu, Tanskanen, Tomas J, Tarabichi, Maxime, Tarnuzzer, Roy, Tarpey, Patrick, Taschuk, Morgan L, Tatsuno, Kenji, Tavaré, Simon, Taylor, Darrin F, Taylor-Weiner, Amaro, Teague, Jon W, Teh, Bin Tean, Tembe, Varsha, Temes, Javier, Thai, Kevin, Thayer, Sarah P, Thiessen, Nina, Thomas, Gilles, Thomas, Sarah, Thompson, Alan, Thompson, Alastair M, Thompson, John FF, Thompson, R Houston, Thorne, Heather, Thorne, Leigh B, Thorogood, Adrian, Tiao, Grace, Tijanic, Nebojsa, Timms, Lee E, Tirabosco, Roberto, Tojo, Marta, Tommasi, Stefania, Toon, Christopher W, Toprak, Umut H, Tortora, Giampaolo, Tost, Jörg, Totoki, Yasushi, Townend, David, Traficante, Nadia, Treilleux, Isabelle, Trotta, Jean-Rémi, Trümper, Lorenz HP, Tsao, Ming, Tsunoda, Tatsuhiko, Tucker, Olga, Turkington, Richard, Turner, Daniel J, Tutt, Andrew, Ueno, Masaki, Ueno, Naoto T, Umbricht, Christopher, Umer, Husen M, Underwood, Timothy J, Urban, Lara, Urushidate, Tomoko, Ushiku, Tetsuo, Uusküla-Reimand, Liis, Valencia, Alfonso, Van Den Berg, David J, Van Laere, Steven, Van Loo, Peter, Van Meir, Erwin G, Van den Eynden, Gert G, Van der Kwast, Theodorus, Vasudev, Naveen, Vazquez, Miguel, Vedururu, Ravikiran, Veluvolu, Umadevi, Vembu, Shankar, Verbeke, Lieven PC, Vermeulen, Peter, Verrill, Clare, Viari, Alain, Vicente, David, Vicentini, Caterina, VijayRaghavan, K, Viksna, Juris, Vilain, Ricardo E, Vincent-Salomon, Anne, Visakorpi, Tapio, Voet, Douglas, Vyas, Paresh, Vázquez-García, Ignacio, Waddell, Nick M, Wadelius, Claes, Wadi, Lina, Wagener, Rabea, Wang, Jian, Wang, Jiayin, Wang, Linghua, Wang, Qi, Wang, Wenyi, Wang, Yumeng, Wang, Zhining, Waring, Paul M, Warnatz, Hans-Jörg, Warrell, Jonathan, Warren, Anne Y, Waszak, Sebastian M, Wedge, David C, Weichenhan, Dieter, Weinberger, Paul, Weinstein, John N, Weisenberger, Daniel J, Welch, Ian, Wendl, Michael C, Werner, Johannes, Whalley, Justin P, Wheeler, David A, Whitaker, Hayley C, Wigle, Dennis, Wilkerson, Matthew D, Williams, Ashley, Wilmott, James S, Wilson, Gavin W, Wilson, Julie M, Wilson, Richard K, Winterhoff, Boris, Wintersinger, Jeffrey A, Wiznerowicz, Maciej, Wolf, Stephan, Wong, Bernice H, Wong, Tina, Wong, Winghing, Woo, Youngchoon, Wood, Scott, Wouters, Bradly G, Wright, Adam J, Wright, Derek W, Wright, Mark H, Wu, Chin-Lee, Wu, Dai-Ying, Wu, Guanming, Wu, Jianmin, Wu, Kui, Wu, Yang, Wu, Zhenggang, Xi, Liu, Xia, Tian, Xiang, Qian, Xiao, Xiao, Xing, Rui, Xiong, Heng, Xu, Qinying, Xu, Yanxun, Xue, Hong, Yachida, Shinichi, Yakneen, Sergei, Yamaguchi, Rui, Yamaguchi, Takafumi N, Yamamoto, Masakazu, Yamamoto, Shogo, Yamaue, Hiroki, Yang, Fan, Yang, Huanming, Yang, Jean Y, Yang, Liming, Yang, Shanlin, Yang, Tsun-Po, Yang, Yang, Yaspo, Marie-Laure, Yates, Lucy, Yau, Christina, Ye, Chen, Ye, Kai, Yellapantula, Venkata D, Yoon, Christopher J, Yousif, Fouad, Yu, Jun, Yu, Kaixian, Yu, Willie, Yu, Yingyan, Yuan, Ke, Yuan, Yuan, Yuen, Denis, Yung, Christina K, Zaikova, Olga, Zapatka, Marc, Zenklusen, Jean C, Zenz, Thorsten, Zeps, Nikolajs, Zhang, Fan, Zhang, Hailei, Zhang, Hongwei, Zhang, Hongxin, Zhang, Jiashan, Zhang, Jing, Zhang, Junjun, Zhang, Xiuqing, Zhang, Xuanping, Zhang, Yan, Zhang, Zemin, Zhao, Zhongming, Zheng, Liangtao, Zheng, Xiuqing, Zhou, Wanding, Zhou, Yong, Zhu, Bin, Zhu, Hongtu, Zhu, Jingchun, Zhu, Shida, Zou, Lihua, Zou, Xueqing, deFazio, Anna, van As, Nicholas, van Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXXtrunc) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXXtrunc tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer.
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- 2023
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182. MicroRNAs in Hematologic Malignancies
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Bloehdorn, Johannes, Rouhi, Arefeh, Dhanyamraju, Pavan Kumar, Krowiorz, Kathrin, Schneider, Edith, Langer, Christian, Mertens, Daniel, Stilgenbauer, Stephan, Kuchenbauer, Florian, and Fabbri, Muller, editor
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- 2014
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183. Venetoclax: Targeting BCL2 in Hematological Cancers
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Scheffold, Annika, primary, Jebaraj, Billy Michael Chelliah, additional, and Stilgenbauer, Stephan, additional
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- 2018
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184. Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling
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Seyfried, Felix, Demir, Salih, Hörl, Rebecca Louise, Stirnweiß, Felix Uli, Ryan, Jeremy, Scheffold, Annika, Villalobos-Ortiz, Mariana, Boldrin, Elena, Zinngrebe, Julia, Enzenmüller, Stefanie, Jenni, Silvia, Tsai, Yi-Chien, Bornhauser, Beat, Fürstberger, Axel, Kraus, Johann Michael, Kestler, Hans Armin, Bourquin, Jean-Pierre, Stilgenbauer, Stephan, Letai, Anthony, Debatin, Klaus-Michael, and Meyer, Lüder Hinrich
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- 2019
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185. Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
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López, Cristina, Kleinheinz, Kortine, Aukema, Sietse M., Rohde, Marius, Bernhart, Stephan H., Hübschmann, Daniel, Wagener, Rabea, Toprak, Umut H., Raimondi, Francesco, Kreuz, Markus, Waszak, Sebastian M., Huang, Zhiqin, Sieverling, Lina, Paramasivam, Nagarajan, Seufert, Julian, Sungalee, Stephanie, Russell, Robert B., Bausinger, Julia, Kretzmer, Helene, Ammerpohl, Ole, Bergmann, Anke K., Binder, Hans, Borkhardt, Arndt, Brors, Benedikt, Claviez, Alexander, Doose, Gero, Feuerbach, Lars, Haake, Andrea, Hansmann, Martin-Leo, Hoell, Jessica, Hummel, Michael, Korbel, Jan O., Lawerenz, Chris, Lenze, Dido, Radlwimmer, Bernhard, Richter, Julia, Rosenstiel, Philip, Rosenwald, Andreas, Schilhabel, Markus B., Stein, Harald, Stilgenbauer, Stephan, Stadler, Peter F., Szczepanowski, Monika, Weniger, Marc A., Zapatka, Marc, Eils, Roland, Lichter, Peter, Loeffler, Markus, Möller, Peter, Trümper, Lorenz, Klapper, Wolfram, ICGC MMML-Seq Consortium, Hoffmann, Steve, Küppers, Ralf, Burkhardt, Birgit, Schlesner, Matthias, and Siebert, Reiner
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- 2019
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186. Real‐world experience among patients with relapsed/refractory mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure in Europe: The SCHOLAR‐2 retrospective chart review study.
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Hess, Georg, Dreyling, Martin, Oberic, Lucie, Gine, Eva, Zinzani, Pier Luigi, Linton, Kim, Vilmar, Adam, Jerkeman, Mats, Chen, Jenny M. H., Ohler, Anke, Stilgenbauer, Stephan, Thieblemont, Catherine, Lambert, Jonathan, Zilioli, Vittorio Ruggero, Sancho, Juan‐Manuel, Jiménez‐Ubieto, Ana, Fischer, Luca, Eyre, Toby A., Keeping, Sam, and Park, Julie E.
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BRUTON tyrosine kinase ,PROTEIN-tyrosine kinase inhibitors ,PATIENTS' attitudes ,CHIMERIC antigen receptors - Abstract
Summary: Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR‐2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory MCL in Europe who were treated with BTKi‐based therapy between July 2012 and July 2018, and had experienced disease progression while on BTKi therapy or discontinued BTKi therapy due to intolerance. The median overall survival (OS) from initiation of first BTKi therapy was 14.6 months (95% confidence interval [CI] 11.6–20.0) in the overall cohort, 5.5 months (95% CI 3.9–8.2) in 91 patients without post‐BTKi therapy, and 23.8 months (95% CI 18.9–30.1) in 149 patients who received post‐BTKi therapy (excluding chimeric antigen receptor T‐cell treatment). In the latter group, patients received a median of one (range, one to seven) line of post‐BTKi therapy, with lenalidomide‐containing regimens and bendamustine plus rituximab being the most frequently administered; the median OS from initiation of first post‐BTKi therapy was 9.7 months (95% CI 6.3–12.7). These results provide a benchmark for survival in patients with R/R MCL receiving salvage therapy after BTKi failure. [ABSTRACT FROM AUTHOR]
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- 2023
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187. Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results
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Wang, Michael L., Blum, Kristie A., Martin, Peter, Goy, Andre, Auer, Rebecca, Kahl, Brad S., Jurczak, Wojciech, Advani, Ranjana H., Romaguera, Jorge E., Williams, Michael E., Barrientos, Jacqueline C., Chmielowska, Ewa, Radford, John, Stilgenbauer, Stephan, Dreyling, Martin, Jedrzejczak, Wieslaw Wiktor, Johnson, Peter, Spurgeon, Stephen E., Zhang, Liang, Baher, Linda, Cheng, Mei, Lee, Dana, Beaupre, Darrin M., and Rule, Simon
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- 2015
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188. To β or Not to β: How Important Is β-Catenin Dependent and Independent WNT Signaling in CLL?
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Urbanek, Karol D., primary, Stilgenbauer, Stephan, additional, and Mertens, Daniel, additional
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- 2022
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189. Nucleosome repositioning in chronic lymphocytic leukaemia
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Piroeva, Kristan V., primary, McDonald, Charlotte, additional, Xanthopoulos, Charalampos, additional, Fox, Chelsea, additional, Clarkson, Christopher T., additional, Mallm, Jan-Philipp, additional, Vainshtein, Yevhen, additional, Ruje, Luminita, additional, Klett, Lara C., additional, Stilgenbauer, Stephan, additional, Mertens, Daniel, additional, Kostareli, Efterpi, additional, Rippe, Karsten, additional, and Teif, Vladimir B., additional
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- 2022
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190. Effects on Survival of Non-Myeloablative Chemoimmunotherapy Compared to High-Dose Chemotherapy Followed By Autologous Stem Cell Transplantation (HDC-ASCT) As Consolidation Therapy in Patients with Primary CNS Lymphoma - Results of an International Randomized Phase III Trial (MATRix/IELSG43)
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Illerhaus, Gerald, primary, Ferreri, Andrés J.M., additional, Binder, Mascha, additional, Borchmann, Peter, additional, Hasenkamp, Justin, additional, Stilgenbauer, Stephan, additional, Roeth, Alexander, additional, Weber, Thomas, additional, Egerer, Gerlinde, additional, Ernst, Thomas, additional, Hertenstein, Bernd, additional, Lenz, Georg, additional, Kobbe, Guido, additional, Brunnberg, Uta, additional, Schmidt, Christian, additional, Kneba, Michael, additional, Dreyling, Martin, additional, Möhle, Robert, additional, Panse, Jens, additional, Heinicke, Thomas, additional, Schroll, Sebastian, additional, Larsen, Thomas S., additional, Salwender, Hans, additional, Naumann, Ralph, additional, Hess, Georg, additional, Thurner, Lorenz, additional, Pukrop, Tobias, additional, Keller, Ulrich, additional, Blystadt, Anne Kirsti, additional, Kroschinsky, Frank P., additional, Re, Francesca, additional, Pulczynski, Elisa, additional, Orsucci, Lorella, additional, Pospiech, Lisa, additional, Deckert, Martina, additional, Ponzoni, Maurilio, additional, Wendler, Julia, additional, Valk, Elke, additional, Calimeri, Teresa, additional, Kasenda, Benjamin, additional, Trepel, Martin, additional, Fricker, Heidi, additional, von Gottberg, Philipp, additional, Burger, Elvira, additional, Ihorst, Gabriele, additional, Grishina, Olga, additional, Hader, Claudia, additional, Zucca, Emanuele, additional, Finke, Jürgen, additional, and Schorb, Elisabeth, additional
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- 2022
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191. In VivoModeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities
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ten Hacken, Elisa, primary, Sewastianik, Tomasz, additional, Yin, Shanye, additional, Hoffmann, Gabriela Brunsting, additional, Gruber, Michaela, additional, Clement, Kendell, additional, Penter, Livius, additional, Redd, Robert A., additional, Ruthen, Neil, additional, Hergalant, Sébastien, additional, Sholokhova, Alanna, additional, Fell, Geoffrey, additional, Parry, Erin M., additional, Broséus, Julien, additional, Guieze, Romain, additional, Lucas, Fabienne, additional, Hernández-Sánchez, María, additional, Baranowski, Kaitlyn, additional, Southard, Jackson, additional, Joyal, Heather, additional, Billington, Leah, additional, Regis, Fara Faye D., additional, Witten, Elizabeth, additional, Uduman, Mohamed, additional, Knisbacher, Binyamin A., additional, Li, Shuqiang, additional, Lyu, Haoxiang, additional, Vaisitti, Tiziana, additional, Deaglio, Silvia, additional, Inghirami, Giorgio, additional, Feugier, Pierre, additional, Stilgenbauer, Stephan, additional, Tausch, Eugen, additional, Davids, Matthew S., additional, Getz, Gad, additional, Livak, Kenneth J., additional, Bozic, Ivana, additional, Neuberg, Donna S., additional, Carrasco, Ruben D., additional, and Wu, Catherine J., additional
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- 2022
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192. Efficacy and safety of obinutuzumab combined with fludarabine and cyclophosphamide (FCG) or bendamustine (BG) in relapsed or refractory CLL patients followed by maintenance therapy with obinutuzumab for responding patients
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Kutsch, Nadine, primary, Holmes, Emily Eva, additional, Robrecht, Sandra, additional, Schüler, Gudrun, additional, Vehling-Kaiser, Ursula, additional, Decker, Thomas, additional, Müller-Hagen, Sigrun, additional, Heinisch, Karin, additional, Böttcher, Sebastian, additional, Ritgen, Matthias, additional, Kreuzer, Karl-Anton, additional, Stilgenbauer, Stephan, additional, Fink, Anna Maria, additional, Fischer, Kirsten, additional, Eichhorst, Barbara, additional, Hallek, Michael, additional, and Wendtner, Clemens-Martin, additional
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- 2022
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193. Proteogenomic Analysis of SF3B1 mut CLL Reveals Altered Protein Signaling Cascades and Metabolomic Pathways
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Klaeger, Susan, primary, Tausch, Eugen, additional, Knisbacher, Binyamin A., additional, Apffel, Annie, additional, Clauser, Karl R, additional, Williams, Corinne, additional, Clish, Clary, additional, Rassenti, Laura Z., additional, Kipps, Thomas J., additional, Fischer, Kirsten, additional, Hallek, Michael, additional, Gillette, Michael A, additional, Neuberg, Donna S., additional, Getz, Gad, additional, Mani, DR, additional, Stilgenbauer, Stephan, additional, Wu, Catherine J., additional, and Carr, Steven A, additional
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- 2022
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194. Preliminary Results of Voice (Virtual Opinions poll Independent Centered on CLL patients’ Experience): A Global Survey to Assess the Disease-Specific Knowledge and Perspectives of Real-World Patients with CLL
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Tam, Constantine S., primary, Pinilla Ibarz, Javier, additional, Karakus, Volkan, additional, Moura, Catherine, additional, Pavlovsky, Miguel Arturo, additional, Piotrowsky, Fernando Nicolás, additional, Šimkovič, Martin, additional, Smith, Andrew, additional, and Stilgenbauer, Stephan, additional
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- 2022
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195. Novel BTK Mutations Conferring Resistance to Non-Covalent BTK Inhibitors and Alternative Treatment Strategy
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Qi, Jialei, primary, Endres, Sascha, additional, Yosifov, Deyan Yordanov, additional, Tausch, Eugen, additional, Dheenadayalan, Rashmi Priyadharshini, additional, Gao, Xiang, additional, Scheffold, Annika, additional, Seyfried, Felix, additional, Meyer, Lüder, additional, Schneider, Christof, additional, Mertens, Daniel, additional, Gierschik, Peter, additional, Wist, Martin, additional, Stilgenbauer, Stephan, additional, and Jebaraj, Billy Michael Chelliah, additional
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- 2022
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196. Longitudinal Omics Data Followed By Preclinical Treatment Studies Identify Proteasome Inhibition As Effective Therapy for Ibrutinib-Resistant Chronic Lymphocytic Leukemia
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Arseni, Lavinia, primary, Sigismondo, Gianluca, additional, Hermansen, Johanne U, additional, Skånland, Sigrid S, additional, Tausch, Eugen, additional, Stilgenbauer, Stephan, additional, Krijgsveld, Jeroen, additional, Lichter, Peter, additional, Zapatka, Marc, additional, and Seiffert, Martina, additional
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- 2022
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197. Assessing the Burden of Adverse Events in a Head-to-Head Trial of Acalabrutinib Versus Ibrutinib in Previously Treated Chronic Lymphocytic Leukemia (CLL)
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Seymour, John F., primary, Byrd, John C., additional, Munir, Talha, additional, Ghia, Paolo, additional, Kater, Arnon P., additional, Chanan-Khan, Asher, additional, Furman, Richard R., additional, O'Brien, Susan, additional, Brown, Jennifer R., additional, Mato, Anthony R., additional, Stilgenbauer, Stephan, additional, Fehn, Thomas, additional, de Miranda, Paulo Andre P., additional, Higgins, Kara, additional, John, Ellie, additional, de Borja, Marianne, additional, Jurczak, Wojciech, additional, and Woyach, Jennifer A., additional
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- 2022
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198. Fludarabine, Cyclophosphamide and Rituximab (FCR) As First Line Treatment in Patients with Chronic Lymphocytic Leukemia (CLL): A Long-Term Analysis of the German CLL Study Group (GCLLSG) Registry
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Kutsch, Nadine, primary, Fink, Anna Maria, additional, Federhen, Anno, additional, Giza, Adam, additional, Robrecht, Sandra, additional, Stumpf, Janina, additional, Stoltefuß, Andrea, additional, Vehling-Kaiser, Ursula, additional, Koenigsmann, Michael, additional, Tausch, Eugen, additional, Schneider, Christof, additional, Stilgenbauer, Stephan, additional, Illmer, Thomas, additional, Schlag, Rudolf, additional, Dörfel, Steffen, additional, Gaska, Tobias, additional, Kiehl, Michael G., additional, Fischer, Kirsten, additional, Eichhorst, Barbara, additional, and Hallek, Michael, additional
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- 2022
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199. Predictive Value of Minimal Residual Disease on Efficacy of Rituximab Maintenance in Mantle Cell Lymphoma: Results from the European MCL Elderly Trial
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Hoster, Eva, primary, Delfau, Marie-Helene, additional, Macintyre, Elizabeth A., additional, Jiang, Linmiao, additional, Stilgenbauer, Stephan, additional, Vehling-Kaiser, Ursula, additional, Salles, Gilles, additional, Thieblemont, Catherine, additional, Tilly, Hervé, additional, Kanz, Lothar, additional, Feugier, Pierre, additional, Huebel, Kai, additional, Schmidt, Christian, additional, Ribrag, Vincent, additional, Kluin-Nelemans, Hanneke, additional, Dreyling, Martin, additional, and Pott, Christiane, additional
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- 2022
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200. High Karyotypic Complexity and Translocations Are Adverse Prognostic Features in Patients with Chronic Lymphocytic Leukemia without TP53 Aberrations Treated with Venetoclax-Based Time-Limited Combinations
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Furstenau, Moritz, primary, Thus, Yvonne, additional, Robrecht, Sandra, additional, Mellink, Clemens, additional, Van Der Kevie-Kersemaekers, Anne-Marie, additional, Dubois, Julie M.N., additional, Von Tresckow, Julia, additional, Patz, Michaela, additional, Gregor, Michael, additional, Thornton, Patrick, additional, Staber, Philipp B., additional, Tadmor, Tamar, additional, Levin, Mark-David, additional, Da Cunha-Bang, Caspar, additional, Schneider, Christof, additional, Poulsen, Christian Bjørn, additional, Illmer, Thomas, additional, Schöttker, Björn, additional, Janssens, Ann, additional, Christiansen, Ilse, additional, Baumann, Michael, additional, Noesslinger, Thomas, additional, Regelink, Josien, additional, Dompeling, Ellen C, additional, Lindström, Vesa, additional, Juliusson, Gunnar, additional, Widmer, Anouk, additional, Goede, Jeroen Simon, additional, Goldschmidt, Neta, additional, Simon, Florian, additional, De Silva, Nisha, additional, Fink, Anna-Maria, additional, Fischer, Kirsten, additional, Wendtner, Clemens-Martin, additional, Ritgen, Matthias, additional, Brüggemann, Monika, additional, Tausch, Eugen, additional, Stilgenbauer, Stephan, additional, Eldering, Eric, additional, Niemann, Carsten Utoft, additional, Hallek, Michael, additional, Eichhorst, Barbara, additional, Kreuzer, Karl-Anton, additional, and Kater, Arnon P., additional
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- 2022
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