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ABSTRACT: Background: The past decade has witnessed a revolution in smartphones owing to their growing importance and various applications. However, excessive usage can lead to addiction and joint pain in the wrist/thumb area. Despite these negative effects, smartphones offer medical students access to the resources they need. Objective: To determine the association between smartphone addiction and thumb/wrist pain among undergraduate students of Jazan University. Methods: A cross-sectional self-administrated, online survey and online convenience sample technique was used. The collected data were analyzed using SPSS Software. Results: This survey included 337 participants, of which two-thirds were female (66.8%) and the rest male (33.2%); 32.6% of the respondents were studying in the College of Medicine. Of the 337 participants, 32% reported experiencing pain in their wrists or at the back of their neck while using a smartphone. The study found an average Smartphone Addition Scale-Short Version (SAS-SV) score of 32.5 ± 8.0 out of 50 and a total Patient-Rated Wrist Evaluation score of 48.8 ± 14.7, with a pain score of 13.3 ± 11.0 and a function score of 35.5 ± 11.7. The study also revealed a significant association between smartphone addiction and thumb/wrist pain (P value = 0.029), with females and students of the College of Applied Medical Science associated with higher SAS-SV scores, thereby indicating higher smartphone addiction. Conclusion: Significant correlation exists between smartphone addiction and thumb/wirst pain among medical students of Jazan University. [ABSTRACT FROM AUTHOR]

The recognition of complementary and alternative medicine (CAM) is increasingly growing worldwide. Positive attitudes toward using CAM may reflect an evidence-based understanding and awareness of its common uses and potential abuses, facilitating its sound integration into the society for positive results. This study aimed to identify the level of knowledge, practices, and barriers associated with the use of CAM among medical and nonmedical students. A cross-sectional study was conducted between April 2023 and July 2023 involving a sample group of medical and nonmedical students from King Khalid University, Abha, Saudi Arabia. A total of 341 students completed the survey. Approximately 53.4% of the participants were medical and 46.6% were nonmedical students. Herbal medicine was the most used among medical students (21%) followed by aromatherapy (12%) and chiropractic (11%), while the most used CAM among nonmedical students was spiritual healing/Quran (19%). The prevalence of good knowledge is higher in medical students compared to nonmedical students in some CAM modalities. In addition, the results show that there are no significant differences in attitudes toward CAM among medical and nonmedical students. Respondents from both groups were keen on gaining more knowledge about all the CAM modalities. It is important to utilize the data from this study for enhancing curricula in university programs and promoting education and practice related to CAM. [ABSTRACT FROM AUTHOR]

This study evaluated the anti-oxidant and anti-diabetic potential of Caralluma fimbriata (CF) in 28-days rat modelling trial. Diabetes is a chronic disorder characterized by elevated blood glucose levels and insulin resistance and cause microvascular and macrovascular issues. Caralluma fimbriata was evaluated for its nutritional composition along with anti-oxidant potential of CF powder (CFP) and CF extract (CFE) using total phenolic contents (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) assays. Furthermore, anti-diabetic potential was computed by dividing rats into four groups of 5 individuals each. Rats of Group I was non-diabetic and no supplementation was given while rats of group II were diabetic and no supplementation was given. While group III and group IV rats were diabetic and received CFP and CFE supplementation respectively. CF powder's TPC, and DPPH and FRAP activity were observed maximum at 44.17 ± 0.006 (μgFe/g) in water, 68.75 ± 0.49 (μgFe/g) in acetone and 800.81 ± 0.99 (μgFe/g) in hexane. Supplementation of CFP and CFE reduced blood glucose effectively i.e. (125.00 ± 4.04 and 121.00 ± 4.49 mg/dL, respectively). Moreover, the consumption of C. fimbriata can be helpful in the management of diabetes mellitus due to its glucose lowering potential, anorexic effects, anti-oxidant potential and α-amylase inhibition. [ABSTRACT FROM AUTHOR]

This paper presents a comparative study between traditional and intelligent Maximum Power Point Tracking (MPPT) algorithms for Photovoltaic (PV) powered DC Shunt Motors. Given the nonlinearity of PV systems, they require nonstandard approaches to harness their full potential. Each PV module has a unique maximum power point on its IV curve due to its nonlinear characteristic nature. Power electronic converters are utilized to enable operation at that point. There are many different algorithms described in the introduction, each with its have their own advantages and drawbacks. Recognizing the potential enhancement of PV system efficiency through effective Maximum Power Point (MPP) tracking, this paper evaluates five MPPT methods under varying DC loads. The five algorithms will be as follows: Incremental Conductance and Perturb and Observe as traditional algorithms. Fuzzy Logic Control, Artificial Neural Networks, and Adaptive Neuro-Fuzzy Inference Systems as Intelligent Algorithms. While traditional algorithms generally produced acceptable results except for Perturb & Observe, intelligent algorithms performed well under rapidly changing solar radiation conditions. Due to inadequate data, intelligent algorithms relying on data training struggled to track the maximum power point when the temperature changed due to inadequate data used for the training. The analysis focuses on the time required by each method to reach peak power under different load conditions, solar irradiance, and temperature variations. The advantages and disadvantages of each MPPT with a shunt DC motor are detailed in the comparative study. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study is to explore the use of sleeping aids among physicians in Saudi Arabia and its correlation with stress and insomnia during the COVID-19 pandemic. Materials and Methods: A sample of 1313 physicians was collected through an online cross-sectional convenience survey. The survey was E-mailed by the Saudi Commission for Health Specialties to the registered physicians in Saudi Arabia during the COVID-19 pandemic. It includes questions related to personal and sociodemographic characteristics, COVID-19, sleep-aid use, the Insomnia Severity Index, and the Perceived Stress Scale. Results: The participants were from various job levels (398 consultants, 1919 registrars, and 716 residents) and mainly from the central (38.2%) and Western (35%) regions. More than a third of them were using sleep aids (38.6%), which were mostly melatonin (75.7%). More than half of them had insomnia (67.1%), and the majority had moderate to high perceived stress (80.1%). Significant associations were found between insomnia and a number of personal and sociodemographic characteristics: Single status, young physicians, residents, smokers, and involvement in a COVID-19 management team. Other significant associations were found between stress and a number of personal and sociodemographic characteristics: Female sex, single status, young physicians, residents, working in the Ministry of Health, being on call 5–8 times/month, and involvement in a COVID-19 management team. Conclusions: Physicians in Saudi Arabia have had increased insomnia, stress, and use of sleep aids during the COVID-19 pandemic. Single, young physicians need more attention to support their psychological well-being.

Malware variants are the major emerging threats that face cybersecurity due to the potential damage to computer systems. Many solutions have been proposed for detecting malware variants. However, accurate detection is challenging due to the constantly evolving nature of the malware variants that cause concept drift. Existing malware detection solutions assume that the mapping learned from historical malware features will be valid for new and future malware. The relationship between input features and the class label has been considered stationary, which doesn’t hold for the ever-evolving nature of malware variants. Malware features change dynamically due to code obfuscations, mutations, and the modification made by malware authors to change the features’ distribution and thus evade the detection rendering the detection model obsolete and ineffective. This study presents an Adaptive behavioral-based Incremental Batch Learning Malware Variants Detection model using concept drift detection and sequential deep learning (AIBL-MVD) to accommodate the new malware variants. Malware behaviors were extracted using dynamic analysis by running the malware files in a sandbox environment and collecting their Application Programming Interface (API) traces. According to the malware first-time appearance, the malware samples were sorted to capture the malware variants’ change characteristics. The base classifier was then trained based on a subset of historical malware samples using a sequential deep learning model. The new malware samples were mixed with a subset of old data and gradually introduced to the learning model in an adaptive batch size incremental learning manner to address the catastrophic forgetting dilemma of incremental learning. The statistical process control technique has been used to detect the concept drift as an indication for incrementally updating the model as well as reducing the frequency of model updates. Results from extensive experiments show that the proposed model is superior in terms of detection rate and efficiency compared with the static model, periodic retraining approaches, and the fixed batch size incremental learning approach. The model maintains an average of 99.41% detection accuracy of new and variants malware with a low updating frequency of 1.35 times per month.

The textile and leather industry produces large amounts of wastewater that contains high levels of chemicals and other pollutants, incorporated during the processing stages. We evaluated the efficacy of green synthesized iron oxide (α-Fe2O3) and magnesium oxide (MgO) nanoparticles (NPs) for wastewater treatment of crude textile and tannery effluents. Green synthesis of α-Fe2O3-NPs and MgO-NPs was conducted using the newly obtained Aspergillus carbonarious strain D-1. The optimization of the physicochemical parameters for the biosynthesis of NPs, including incubation periods, contact time, pH, temperature, and precursor concentrations, were assessed. The characterization of NPs obtained under optimal conditions was evaluated using UV–visible spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD) patterns, dynamic light scattering (DLS), and Fourier Transform Infrared (FT-IR) Spectroscopy. The optimal concentration for efficient textile/tannery wastewater decolorization was determined to be 100 mg NPs after eight hours for α-Fe2O3-NPs and after four hours for MgO-NPs. Under these conditions, chemical oxygen deman (COD), pH value, total dissolved solids (TDS), total suspended solids (TSS), and conductivity were greatly reduced as compared to control for crude textile wastewater. GC–MS analysis of NPs-treated textile wastewater revealed that some major compounds were greatly diminished, bio-transformed, or completely degraded. MgO and α-Fe2O3 NPs exhibited a high capacity to reduce the COD of tannery wastewater by 97.5% and 95.0%, respectively. Hematite NPs exhibited higher removal capacity for TDS, TSS, and conductivity compared to MgO-NPs. MgO and hematite NPs exhibited high capacities to remove Cr, with MgO redcing Cr by 87.06 and hematite NPs reducing Cr by 75.4%. MgO-NPs were more effective than α-Fe2O3-NPs at removing Pb, Ni, and Cd.

There is an urgent need to design new anticancer agents that can prevent cancer cell proliferation even with minimal side effects. Accordingly, two new series of 3-methylquinoxalin-2(1H)-one and 3-methylquinoxaline-2-thiol derivatives were designed to act as VEGFR-2 inhibitors. The designed derivatives were synthesised and evaluated in vitro as cytotoxic agents against two human cancer cell lines namely, HepG-2 and MCF-7. Also, the synthesised derivatives were assessed for their VEGFR-2inhibitory effect. The most promising member 11e were further investigated to reach a valuable insight about its apoptotic effect through cell cycle and apoptosis analyses. Moreover, deep investigations were carried out for compound 11e using western-plot analyses to detect its effect against some apoptotic and apoptotic parameters including caspase-9, caspase-3, BAX, and Bcl-2. Many in silico investigations including docking, ADMET, toxicity studies were performed to predict binding affinity, pharmacokinetic, drug likeness, and toxicity of the synthesised compounds. The results revealed that compounds 11e, 11g, 12e, 12g, and 12k exhibited promising cytotoxic activities (IC50 range is 2.1 − 9.8 µM), comparing to sorafenib (IC50 = 3.4 and 2.2 µM against MCF-7 and HepG2, respectively). Moreover, 11b, 11f, 11g, 12e, 12f, 12g, and 12k showed the highest VEGFR-2 inhibitory activities (IC50 range is 2.9 − 5.4 µM), comparing to sorafenib (IC50 = 3.07 nM). Additionally, compound 11e had good potential to arrest the HepG2 cell growth at G2/M phase and to induce apoptosis by 49.14% compared to the control cells (9.71%). As well, such compound showed a significant increase in the level of caspase-3 (2.34-fold), caspase-9 (2.34-fold), and BAX (3.14-fold), and a significant decrease in Bcl-2 level (3.13-fold). For in silico studies, the synthesised compounds showed binding mode similar to that of the reference compound (sorafenib).

Nasal swaps were collected from 405 elementary school boys of eight governmental schools located within several districts in Al-Madinah city to be screened for asymptomatic carriage of potential Staphylococcus pathogens. A total of 138 Gram-positive staphylococci isolates (34%) showing blood hemolysis were selected. Based on their morphological, cultural characteristics and Restriction enzyme analysis Isolates were grouped into 12 phenotypic within four distinct clusters. The 16S rDNA sequence analysis of all isolates revealed S. aureus to be the most prevalent (80%), followed by S. epidermidis (9%) and finally S. hominis and S. simulans accounting for 6% and 5% respectively. Staphylococcus isolates were detected with higher frequency in participants of age group 7–9 years, with the lowest numbers of staphylococci (18%) isolated from the schools located in the western area. Multiplex PCR assay revealed that all S. aureus isolates (20%) which were phenotypically recognized as MRSA by the Kirby–Bauer disc diffusion method contained the mecA gene. MecA gene was also detected in three coagulase-negative staphylococci isolates.

The main aim of the topically applied drugs is to provide local drug contact to the skin and minimize general absorption of drugs. Ocimum basilicum (OB) is popular for folk medicines, having official acceptance in many countries. The aim of this study was to formulate and evaluate the efficacy of topical application of OB-based emulgel on wound healing in animal model. The prepared formulations (OB emulgel) were assessed for FTIR analysis, stability studies, physical appearance, rheological behavior, spreadability, patch/sensitivity test and in vitro drug release. The in vivo wound healing effect was evaluated and compared with commercially available Silver Sulfadiazine cream Quench® in wound-induced rabbits by macroscopic and histopathological evidence. The OB extract/drug was compatible with the selected polymer and other excipients and indicated the suitability of the polymers/excipients for preparation of topical emulgel. The formulated OB emulgel exhibited good physical properties. The release profile of emulgel was satisfactory and released 81.71 ± 1.7% of the drug in 250 min. In vivo wound healing studies showed that OB emulgel exhibited the highest percent wound contraction similar to the commercial product (p > 0.05). This activity was statistically significant (p

Based on the analysis of the individual composition of biomarkers of oils from the Lower Cretaceous, Lower Jurassic, Paleozoic and Proterozoic of the Aryskum depression of the South Torgai oil and gas basin, the conditions for formation of oil source deposits generating oil of the territory under consideration are reconstructed. The study is relevant to justify the search strategy for oil and gas deposits, taking into account the tectonics of the foundation of South Kazakhstan. The aim of the study was to identify similarities and differences between the oils lying in the pre-Jurassic deposits of the Aryskum trough basement and oils from sedimentary strata overlapping them, to determine the features of facies conditions for accumulation of oil source material in this territory. Objects and methods. Oil from the Lower Cretaceous, Lower Jurassic, Paleozoic, and Proterozoic of the Aryskum depression of the South Torgai oil and gas basin was studied. The composition of the oils was analyzed by gas-liquid chromatography and gas chromatography-mass spectrometry. Results and conclusions. The distribution in oils and the individual composition of alkanes, n-alkylbenzenes, naphthalenes, phenanthrenes, cheilants, pentacyclic triterpanes and steranes were determined, geochemical parameters reflecting the peculiarities of the conditions for formation of oil source deposits were calculated. The data obtained demonstrated the genetic unity of the oils from the Lower Cretaceous and Proterozoic of the Akshabulak graben-synclinal, as well as the unified genesis of oils from the Lower Cretaceous and Paleozoic of the Aksai horst-anticline and the difference in the facies conditions of accumulation of source rocks in these territories. According to the data on composition of steranes and pentacyclic triterpanes, rocks that produced oil within the Akshabulak graben syncline are characterized by a high content of carbonates, accumulated in the deeper part of the sea and in less oxidizing conditions than in the Aksai horst anticline, where the oil source layer contained more clay component and deposited, apparently in a salted lagoon. Oil from the Lower Jurassic of the Bosingen graben-synclinal is generated by sediments formed in the desalinated delta zone.

Salah satu diantara beberapa kompetensi yang dikembangkan dalam kehidupan peserta didik adalah kecerdasan spiritual. Penelitian untuk mendeskripsikan pemakanan peserta didik tentang kecerdasan spiritual. Penelitian ini menggunakan pendekatan deskripsi kuantitatif, pengumpulan data menggunakan angket dan analisis data menggunakan analisis persentase. Hasil penelitian menunjukkan bahwa peserta didik kurang baik dalam memakanakan kecerdasan spiritual dalam kehidupan sehari-hari, meliputi pemaknaan bersifat fleksibel, memaknakan memiliki kesadaran (self-awareness) yang tinggi, pemaknaan kemampuan untuk menghadapi penderitaan dan mengambil hikmah darinya, pemaknaan kemampuan untuk menghadapi dan mengatasi rasa sakit, pemaknaan memiliki kualitas hidup yang diilhami oleh visi dan nilai-nilai, pemaknaan enggan melakukan sesuatu yang menyebabkan kerugian atau kerusakan, pemaknaan cenderung melihat hubungan antar berbagai hal berbeda menjadi suatu yang holistik, pemaknaan cenderung untuk bertanya “mengapa” atau “apa” dan mencari jawaban-jawaban yang fundamental, dan pemaknaan bertanggungjawab untuk menebarkan visi dan nilai-nilai kepada orang lain dan menunjukkan cara menggunakan. Guna mengoptimalkan pemaknaan peserta didik dalam kecerdasan spiritual, dapat dilakukan melalui pendekatan bimbingan dan konseling, serta mengatur dalam bentuk manajemen peserta didik berbasis kecerdasan spiritual.

One of the areas discussed in modern geology is the oil and gas potential of deep horizons, including the basement of sedimentary basins. The genesis of oil deposits is the subject of heated debate. Modern geochemical methods for studying a substance, together with the instrument capabilities, which include an isotopic mass-spectrometer, make it possible to distinguish between oils generated by different oil source deposits. The most important indicator identifying the genesis of hydrocarbons with respect to oil and gas formation zones in a specific section is the isotopic composition of carbon. Each zone, in its turn, is characterized by individual geochemical and thermodynamic parameters, including the type and degree of conversion of dispersed organic matter, modern geothermal temperatures and paleotemperature conditions, and the phase composition of hydrocarbons. Deposits of the Aryskum depression of the South Torgai oil and gas basin (South Kazakhstan) are associated with various lithological-stratigraphic complexes of the Jurassic-Cretaceous deposits, the Devonian-Lower Carboniferous formations of the quasi-platform complex and disintegrated basement ledges. In recent years, the prospects of the South Torgai basin have expanded and are associated with pre-Jurassic deposits. In this regard, there is the issue of the nature of hydrocarbon masses and formation of their clusters in the Mesozoic and Pre-Mesozoic formations of the Aryskum depression. The aim of the research is the comparative analysis of the carbon isotopic composition of oils from the Aryskum depression from the Mesozoic, Paleozoic sediments, as well as the ones from the zone of contact of the Paleozoic with the Mesozoic sedimentary cover to solve genetic problems and elucidate the features of the formation of oil fields in the Aryskum depression. The results made it possible to establish the regularity of the change in the d13С value depending on the age, depth, and territorial confinement of the deposits within the Aryskum depression and, based on isotopic data, make an assumption about the genesis of Mesozoic and Pre-Mesozoic oils.

Culex pipiens (Diptera: Culicidae) is one of the most prevalent mosquitoes particularly in the Al-Madinah Al-Munawwarah region, Kingdom of Saudi Arabia, transmitting numerous diseases such as arboviruses, avian malaria, elephantiasis, dirofilariasis, and encephalitis. Worldwide, Culex pipiens has developed resistance to numerous insecticides; therefore, considerable efforts have been done to introduce new mosquito control candidates. Due to their unique physical, biological, and eco-friendly properties, ionic liquids (ILs) have been recently considered as promising agents in controlling a variety of organisms. Six aminopyridinium-based ionic liquids (IL1–IL6) were assayed against eggs and pupae of C. pipiens. Percentages of non-hatched eggs, non-emerged pupae, the lethal concentrations (LC50 and LC90) of both C. pipiens eggs and pupae were recorded. after exposure, to different ILs. The effects of ILs against eggs and pupae were concentration and IL-dependant. The percentages of egg unhatchability were much higher than those of pupal mortality, as the percentage of egg unhatchability reached 99% after treatment with IL6 at 0.5 g/L, while the percentage of pupal mortality reached 40.8% after treatment with IL4 at 0.5 g/L. The LC50 and LC90 of ILs against pupae were much higher than those of ILs against eggs. Effects of ILs on Staphylococcus aureus (Bacillales: Staphylococcaceae) and Escherichia coli (Entrobacterales: Entrobacteriaceae) were also studied; some ILs showed a considerable effect on both bacteria species. This is the first study to show the ovicidal, pupicidal, and bactericidal effects of aminopyridinium-based ILs in controlling C. pipiens, S. aureus, and E. coli.

An unknown pneumonia outbreak has been reported by hospitals in Wuhan, China, in late December 2019. A public health emergency of international concern announced by the World Health Organization (WHO) on the January 31, 2020. The virus named by the WHO as coronavirus disease 2019 (COVID-19). The cases reached (266,073 cases) and deaths (11,184 deaths) globally by the end of March 21, 2020, and considered as a pandemic. By a systemic review, articles and case reports revealed 74 pregnant women for the possibility of vertical transmission of the virus from COVID-19-infected mother to infant. Review also showed that there is no difference between pregnant and nonpregnant regarding clinical manifestations. Concerning the vertical transmission, none of the positive mothers had a positive infant with COVID-19 except 1 case report that showed the infant had positive COVID-19 by the throat swab, yet negative cord blood, placenta, and mother's breast milk.

Introduction: When it comes to non-communicable diseases like diabetes, inadequate knowledge, attitude, and practice are often linked to poor health outcomes. This study aims to assess the patients’ knowledge, attitude, and practice (KAP) of diabetes in the outpatient department of a university teaching hospital in Saudi Arabia. Methodology: In this cross-sectional study, diabetes type 2 patients attending outpatient departments at a university teaching hospital, Riyadh, were assessed regarding their knowledge, attitude, and practice toward diabetes using a validated KAP scale. Descriptive and inferential analysis was done to determine the factors associated with KAP score using SPSS version 26.0 software (SPSS Inc., Chicago, IL, U.S.). Results: Males made up 69.7% of the sample (n = 165), while 56.9% were between the ages of 41 and 75. The level of knowledge and practice had “good” in 37.6%, and 47.9%, respectively, but level of attitude had “positive” in 30.9% of patients. The association between knowledge tier and gender (p0.014) and insurance status (p0.008), respectively, was shown to be significant. However, the attitude tier was only significantly associated with gender ( P = .003). The practice tier also showed a significant age association ( P = .049). As regards, the mean scores for diabetes-related knowledge were higher only among insured participants ( P = .03) than for other participants’ sociodemographic factors. Meanwhile, the mean attitude scores were also higher among males ( P = .006) than for other sociodemographic characteristics. A comparison of the participants’ sociodemographic characteristics found no statistically significant variations in practice scores. Conclusion: Unfortunately, this study found that outpatient diabetes patients had insufficient knowledge, practice, and a negative attitude toward diabetes type 2. This imposes a great burden on healthcare workers and hence the healthcare system to improve patient scores via diabetes education programs or pharmacist-led patient counseling initiatives.

Background. Nursing care is holistic, and missing any aspect of care can be critical to patients’ health. However, due to the complex and intense nature of the nursing practice, nurses have to unintentionally prioritize some activities, forcing them to omit some aspects of nursing care. Aim. To explore the dimensions of missed nursing care and its predictors within the Saudi Arabian healthcare system. Methods. Quantitative, cross-sectional study used the MISSCARE survey by utilizing nonprobability convenience sampling to collect the data of 604 staff nurses working in inpatient wards in Jazan, Saudi Arabia. Results. The overall mean of missed nursing care is (m = 1.37, SD = 0.45). Missed nursing care activities were mostly failure to attend interdisciplinary care conferences (m = 1.66, SD = 0.96) and patient ambulation thrice a day (m = 1.63, SD = 0.97). Missed nursing care was mainly caused by human resource shortage (m = 3.53, SD = 0.88). Missed nursing care is predicted by the turnover intention (B = 2.380, t = 3.829, p

Inflammation is a defense process triggered when the body faces assaults from pathogens, toxic substances, microbial infections, or when tissue is damaged. Immune and inflammatory disorders are common pathogenic pathways that lead to the progress of various chronic diseases, such as cancer and diabetes. The overproduction of cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, is an essential parameter in the clinical diagnosis of auto-inflammatory diseases. In this review, the effects of bee products have on inflammatory and autoimmune diseases are discussed with respect to the current literature. The databases of Google Scholar, PubMed, Science Direct, Sci-Finder and clinical trials were screened using different combinations of the following terms: “immunomodulatory”, “anti-inflammatory”, “bee products”, “honey”, “propolis”, “royal jelly”, “bee venom”, “bee pollen”, “bee bread”, “preclinical trials”, “clinical trials”, and “safety”. Honey bee products, including propolis, royal jelly, honey, bee venom, and bee pollen, or their bioactive chemical constituents like polyphenols, demonstrate interesting therapeutic potential in the regulation of inflammatory mediator production as per the increase of TNF-α, IL-1β, IL-6, Il-2, and Il-7, and the decrease of reactive oxygen species (ROS) production. Additionally, improvement in the immune response via activation of B and T lymphocyte cells, both in in vitro, in vivo and in clinical studies was reported. Thus, the biological properties of bee products as anti-inflammatory, immune protective, antioxidant, anti-apoptotic, and antimicrobial agents have prompted further clinical investigation.

Introduction: Sustaining a healthy work environment is a major challenge for health care organizations worldwide. Nursing professionals are often exposed to workplace bullying, which imposes serious challenges to nursing retention. Objectives: To determine the prevalence of workplace bullying and turnover intention among nurses, and to investigate the relationship between workplace bullying and nurse turnover. Methods: A cross-sectional correlational design. Convenience sampling was applied, whereby 347 nurses working in a tertiary medical city in Riyadh, Saudi Arabia, were recruited. Data were collected using the Negative Acts Questionnaire and the Anticipated Turnover Scale. Results: The rate of workplace bullying was high, bullying occurred at a cumulative rate of 33.4% ( n = 116). Work related bullying behaviors formed the most common bullying acts with (34.5%) followed by personal bullying with (31.1%) meanwhile physical intimidating accounted by (25.6%). Among the participants, 31.7% exhibited a high turnover intention. The demographic variable age was revealing an inverse correlation with workplace bullying. There was a positive significant correlation between workplace bullying and turnover intentions ( r = .24, p