Search

Your search keyword '"Sun, Haibo"' showing total 1,041 results
Start Over Author "Sun, Haibo"
1,041 results on '"Sun, Haibo"'

156. Axial Compression Behavior of Large-Diameter, Concrete-Filled, Thin-Walled Galvanized Helical Corrugated Steel Tubes Column Embedded with Rebar.

Author

Sun, Haibo, Zhang, Linlin, Liu, Yu, Liu, Baodong, and Feng, Mingyang

Subjects
CONCRETE-filled tubes, COMPOSITE columns, STEEL tubes, COMPRESSION loads, AXIAL loads, GALVANIZING, FAILURE mode & effects analysis
Abstract

Thin-walled galvanized helical corrugated steel tubes (HCSTs) filled with concrete are promising composite members, consisting of concrete, an anti-corrosion shell, and a multifunctional exterior corrugated steel tube. To investigate the synergistic working mechanism of concrete-filled HCSTs (CFHCSTs), six specimens were designed for axial compression tests, with the inner diameter of the column and the volumetric steel ratios of the longitudinal reinforcement as the variation parameters. The results show that HCSTs can better confine the concrete core and increase its strength. The failure mode of HCSTs is significantly influenced by the column's diameter, and those with a smaller diameter are prone to slide failure and lock seam tearing. The strains and stresses on HCSTs are discussed in detail to elucidate the confinement effect. This paper proposes a suitable design method to predict the ultimate axial compression load capacity of CFHCST columns based on early studies on steel tube-confined concrete. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

157. Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations.

Author

Bao, Huayin, Wang, Wei, Sun, Haibo, and Chen, Jianzhong

Subjects
MOLECULAR dynamics, PRINCIPAL components analysis, HYDROGEN bonding interactions, DRUG design, ELECTRICAL conductivity transitions
Abstract

Mutations highly affect the structural flexibility of two switch domains in M-RAS considered an important target of anticancer drug design. Gaussian accelerated molecular dynamics (GaMD) simulations were applied to probe the effect of mutations P40D, D41E, and P40D/D41E/L51R on the conformational transition of the switch domains from the GTP-bound M-RAS. The analyses of free energy landscapes (FELs) not only reveal that three mutations induce less energetic states than the wild-type (WT) M-RAS but also verify that the switch domains are extremely disordered. Principal component analysis (PCA) and dynamics analysis suggest that three mutations greatly affect collective motions and structural flexibility of the switch domains that mostly overlap with binding regions of M-RAS to its effectors, which in turn disturbs the activity of M-RAS. The analyses of the interaction network between GTP and M-RAS show that the high instability in hydrogen bonding interactions (HBIs) of GTP with residue 41 and Y42 in the switch domain I drives the disordered states of the switch domains. This work is expected to provide a molecular mechanism for deeply understanding the function of M-RAS and future drug design towards the treatment of cancers. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

162. Supplemental Figures from Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma

Author

Sun, Haibo, primary, Lin, De-Chen, primary, Cao, Qi, primary, Pang, Brendan, primary, Gae, David D., primary, Lee, Victor Kwan Min, primary, Lim, Huey Jin, primary, Doan, Ngan, primary, Said, Jonathan W., primary, Gery, Sigal, primary, Chow, Marilynn, primary, Mayakonda, Anand, primary, Forscher, Charles, primary, Tyner, Jeffrey W., primary, and Koeffler, H. Phillip, primary

Published
2023
Full Text
View/download PDF

163. Supplemental Tables S1-S9 from Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma

Author

Sun, Haibo, primary, Lin, De-Chen, primary, Cao, Qi, primary, Pang, Brendan, primary, Gae, David D., primary, Lee, Victor Kwan Min, primary, Lim, Huey Jin, primary, Doan, Ngan, primary, Said, Jonathan W., primary, Gery, Sigal, primary, Chow, Marilynn, primary, Mayakonda, Anand, primary, Forscher, Charles, primary, Tyner, Jeffrey W., primary, and Koeffler, H. Phillip, primary

Published
2023
Full Text
View/download PDF

164. Supplemental figure legends from Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma

Author

Sun, Haibo, primary, Lin, De-Chen, primary, Cao, Qi, primary, Pang, Brendan, primary, Gae, David D., primary, Lee, Victor Kwan Min, primary, Lim, Huey Jin, primary, Doan, Ngan, primary, Said, Jonathan W., primary, Gery, Sigal, primary, Chow, Marilynn, primary, Mayakonda, Anand, primary, Forscher, Charles, primary, Tyner, Jeffrey W., primary, and Koeffler, H. Phillip, primary

Published
2023
Full Text
View/download PDF

165. Supplemental Tables from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling

Author

Sun, Haibo, primary, Lin, De-Chen, primary, Cao, Qi, primary, Guo, Xiao, primary, Marijon, Helene, primary, Zhao, Zhiqiang, primary, Gery, Sigal, primary, Xu, Liang, primary, Yang, Henry, primary, Pang, Brendan, primary, Lee, Victor Kwan Min, primary, Lim, Huey Jin, primary, Doan, Ngan, primary, Said, Jonathan W., primary, Chu, Peiguo, primary, Mayakonda, Anand, primary, Thomas, Tom, primary, Forscher, Charles, primary, Baloglu, Erkan, primary, Shacham, Sharon, primary, Rajalingam, Raja, primary, and Koeffler, H. Phillip, primary

Published
2023
Full Text
View/download PDF

166. Supplemental Figures from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling

Author

Sun, Haibo, primary, Lin, De-Chen, primary, Cao, Qi, primary, Guo, Xiao, primary, Marijon, Helene, primary, Zhao, Zhiqiang, primary, Gery, Sigal, primary, Xu, Liang, primary, Yang, Henry, primary, Pang, Brendan, primary, Lee, Victor Kwan Min, primary, Lim, Huey Jin, primary, Doan, Ngan, primary, Said, Jonathan W., primary, Chu, Peiguo, primary, Mayakonda, Anand, primary, Thomas, Tom, primary, Forscher, Charles, primary, Baloglu, Erkan, primary, Shacham, Sharon, primary, Rajalingam, Raja, primary, and Koeffler, H. Phillip, primary

Published
2023
Full Text
View/download PDF

167. Supplemental Figure legends from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling

Author

Sun, Haibo, primary, Lin, De-Chen, primary, Cao, Qi, primary, Guo, Xiao, primary, Marijon, Helene, primary, Zhao, Zhiqiang, primary, Gery, Sigal, primary, Xu, Liang, primary, Yang, Henry, primary, Pang, Brendan, primary, Lee, Victor Kwan Min, primary, Lim, Huey Jin, primary, Doan, Ngan, primary, Said, Jonathan W., primary, Chu, Peiguo, primary, Mayakonda, Anand, primary, Thomas, Tom, primary, Forscher, Charles, primary, Baloglu, Erkan, primary, Shacham, Sharon, primary, Rajalingam, Raja, primary, and Koeffler, H. Phillip, primary

Published
2023
Full Text
View/download PDF

168. Data from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling

Author

Sun, Haibo, primary, Lin, De-Chen, primary, Cao, Qi, primary, Guo, Xiao, primary, Marijon, Helene, primary, Zhao, Zhiqiang, primary, Gery, Sigal, primary, Xu, Liang, primary, Yang, Henry, primary, Pang, Brendan, primary, Lee, Victor Kwan Min, primary, Lim, Huey Jin, primary, Doan, Ngan, primary, Said, Jonathan W., primary, Chu, Peiguo, primary, Mayakonda, Anand, primary, Thomas, Tom, primary, Forscher, Charles, primary, Baloglu, Erkan, primary, Shacham, Sharon, primary, Rajalingam, Raja, primary, and Koeffler, H. Phillip, primary

Published
2023
Full Text
View/download PDF

178. Perioperative Toripalimab Plus Neoadjuvant Chemotherapy Improves Outcomes in Resectable Esophageal Cancer: An Interim Analysis of a Phase III Randomized Clinical Trial (HCHTOG1909)

Author

Zheng, Yan, primary, Liang, Guanghui, additional, Yuan, Dongfeng, additional, Liu, Xianben, additional, Ba, Yufeng, additional, Qi, Zimin, additional, Shen, Sining, additional, Li, Zhenxuan, additional, Sun, Haibo, additional, Liu, Baoxing, additional, Gao, Quanli, additional, Li, Peng, additional, Wang, Zongfei, additional, Liu, Shilei, additional, Zhu, Jianping, additional, Ma, Haibo, additional, Liu, Zhenzhen, additional, Zhao, Fei, additional, Zhang, Jun, additional, Zhang, He, additional, Wu, Daoyuan, additional, Qu, Jinrong, additional, Ma, Jie, additional, Zhang, Peng, additional, Ma, Wenjie, additional, Yan, Ming, additional, Yu, Yongkui, additional, Li, Qing, additional, Zhang, Jiangong, additional, and Xing, Wenqun, additional

Published
2023
Full Text
View/download PDF

200. Study on the Optimal Design of Hydraulic Wedge Brake based on the Simulated Annealing Algorithm

Author

Sun Haibo

Subjects
Hydraulic wedge brake, Optimal design, Simulated annealing algorithm, Experiment, Mechanical engineering and machinery, TJ1-1570
Abstract

In order to solve the problems of large design margin and high manufacturing cost of traditional heavy duty vehicle drum brake,the new type hydraulic wedge type brake is regarded as research subjects,the calculation formulas of wedge brake torque,brake drum surface average temperature,maximum temperature are got,the design of the model is optimized through the simulated annealing algorithm,finally,the optimization model is validated through the finite element calculation and experiment. The results show that the stress value of hydraulic wedge brake after the optimization of the key components can meet the material requirement of use,the hydraulic wedge brake after the optimization in different brake pressure and initial speed of braking conditions braking efficiency is with high stability.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results