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152. Results of the material screening program of the NEXT experiment

Author

G. Martínez-Lema, F.J. Iguaz, Luis M. Serra, D. Lorca, L.M.P. Fernandes, F.I.G.M. Borges, C.M.B. Monteiro, F.J. Mora, N. Yahlali, A. Simón, V. M. Gehman, J.A. Villar, Diego González-Díaz, T. Dafni, V. Álvarez, J. S. Díaz, H. Gómez, J. Martín-Albo, J.J. Gómez-Cadenas, J.M.F. dos Santos, T. Miller, Alessandro Bettini, A Rodríguez, C.A.N. Conde, Luis Labarga, J.T. White, A. Goldschmidt, J. Hauptman, L.M. Moutinho, J. Torrent, M. Sorel, F. Monrabal, L. Ripoll, Marta Losada, A.L. Ferreira, F.P. Santos, M. Nebot-Guinot, Roberto Gutiérrez, I. Liubarsky, J. A. Hernando Morata, D.C. Herrera, A. Marí, I. C. Bandac, J.F. Toledo, S. Cárcel, C. Sofka, A. Martínez, Javier Rodríguez, Manuel Camargo, M. Monserrate, J. Muñoz Vidal, A. Cervera, D. Shuman, Marcos Fernandez, S. Cebrián, R. C. Webb, Romain Esteve, Javier Pérez, J.F.C.A. Veloso, E.D.C. Freitas, G. Luzón, L. Segui, I. G. Irastorza, Paola Ferrario, D. R. Nygren, A. Laing, Zviad Tsamalaidze, J. Renner, J.L. Pérez Aparicio, and C. A. B. Oliveira

Subjects
MECANICA DE LOS MEDIOS CONTINUOS Y TEORIA DE ESTRUCTURAS, Nuclear and High Energy Physics, Particle physics, Physics - Instrumentation and Detectors, Nuclear engineering, FOS: Physical sciences, chemistry.chemical_element, Radiopurity, 01 natural sciences, High Energy Physics - Experiment, TECNOLOGIA ELECTRONICA, High Energy Physics - Experiment (hep-ex), Xenon, Double beta decay, 0103 physical sciences, Germanium gamma spectrometry, Nuclear Experiment (nucl-ex), Gamma ray spectrometry, 010306 general physics, Nuclear Experiment, Physics, Measurement method, 010308 nuclear & particles physics, Gamma ray spectrometer, Canfranc Underground Laboratory, Espectrometria de raigs gamma, Instrumentation and Detectors (physics.ins-det), Semiconductor detector, chemistry, Neutrino
Abstract

The 'Neutrino Experiment with a Xenon TPC (NEXT)', intended to investigate neutrinoless double beta decay, requires extremely low background levels. An extensive material screening and selection process to assess the radioactivity of components is underway combining several techniques, including germanium gamma-ray spectrometry performed at the Canfranc Underground Laboratory; recent results of this material screening program are presented here., Proceedings for a poster contribution at ICHEP 2014, Valencia, Spain

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155. Micromegas for rare event detection

Author

M. J. Pivovaroff, T. Geralis, P Gorodetzky, Regina Soufli, K. van Bibber, S. Aune, J. Morales, I. G. Irastorza, P. Colas, T Enqvist, F.J. Iguaz, G. Luzón, I. Savvidis, T. Dafni, José Villar, Adriane De Assis Lawisch Rodriguez, E. Ferrer-Ribas, A. Tomás, Javier Galan, P. Salin, J. Ruz, I. Giomataris, Georgios Fanourakis, and Konstantinos Kousouris

Subjects
Gaseous detectors, Physics, Particle physics, Time projection chamber, WIMP, Rare event detection, MicroMegas detector, Neutrino, Axion

156. First proof of topological signature in the high pressure xenon gas TPC with electroluminescence amplification for the NEXT experiment

Author

J.F.C.A. Veloso, E.D.C. Freitas, A. Goldschmidt, J. Hauptman, J.F. Toledo, S. Cárcel, P. Lebrun, N. Yahlali, D. Shuman, Romain Esteve, C.D.R. Azevedo, S. Cebrián, R. C. Webb, J.A. Villar, A. Martínez, D. R. Nygren, F.J. Mora, T. Dafni, A. Laing, M. Diesburg, Jorge Luis Rodriguez, A. Simón, I. G. Irastorza, Zviad Tsamalaidze, D. Lorca, M. Monserrate, Marta Losada, J.M.F. dos Santos, J. Muñoz Vidal, T. Miller, N. López-March, Javier Pérez, F.P. Santos, C.A.O. Henriques, Roberto Gutiérrez, J. S. Díaz, P. Novella, I. Liubarsky, J. Martín-Albo, J.J. Gómez-Cadenas, F. Monrabal, F.I.G.M. Borges, J.A. Hernando Morata, L.M. Moutinho, J. Torrent, Paola Ferrario, D. González-Díaz, V. M. Gehman, L. Ripoll, G. Luzón, C. Sofka, A. Para, M. Sorel, A.L. Ferreira, M. Nebot-Guinot, G. Martínez-Lema, J.T. White, L.M.P. Fernandes, A. Marí, M. Querol, A. Cervera, Luis M. Serra, C.M.B. Monteiro, Víctor H. Alvarez, H. Yepes-Ramírez, J. Renner, J.L. Pérez Aparicio, C.A.N. Conde, and Luis Labarga

Subjects
MECANICA DE LOS MEDIOS CONTINUOS Y TEORIA DE ESTRUCTURAS, Nuclear and High Energy Physics, chemistry.chemical_element, Topology (electrical circuits), Electron, Topology, 01 natural sciences, 7. Clean energy, Signal, Atomic, Mathematical Sciences, TECNOLOGIA ELECTRONICA, Nuclear physics, Xenon, Particle and Plasma Physics, Ionization, Double beta decay, 0103 physical sciences, Dark Matter, Nuclear, 010306 general physics, Double Beta Decay, Mathematical Physics, Physics, Quantum Physics, 010308 nuclear & particles physics, Molecular, Beta Decay, Nuclear & Particles Physics, Desintegració beta, chemistry, Dark matter (Astronomy), Physical Sciences, Decay chain, Matèria fosca (Astronomia), Energy (signal processing)
Abstract

[EN] The NEXT experiment aims to observe the neutrinoless double beta decay of 136Xe in a high-pressure xenon gas TPC using electroluminescence (EL) to amplify the signal from ionization. One of the main advantages of this technology is the possibility to reconstruct the topology of events with energies close to Qββ . This paper presents the first demonstration that the topology provides extra handles to reject background events using data obtained with the NEXT-DEMO prototype. Single electrons resulting from the interactions of 22Na 1275 keV gammas and electron-positron pairs produced by conversions of gammas from the 228Th decay chain were used to represent the background and the signal in a double beta decay. These data were used to develop algorithms for the reconstruction of tracks and the identification of the energy deposited at the end-points, providing an extra background rejection factor of 24.3 ± 1.4 (stat.)%, while maintaining an efficiency of 66.7 ± 1.% for signal events., This work was supported by the following agencies and institutions: the European Research Council (ERC) under the Advanced Grant 339787-NEXT; the Ministerio de Economia y Competitividad of Spain under grants CONSOLIDER-Ingenio 2010 CSD2008-0037 (CUP), FPA2009-13697-C04 and FIS2012-37947-C04; the Portuguese FCT and FEDER through the program COMPETE, project PTDC/FIS/103860/2008; and the Fermi National Accelerator Laboratory under U.S. Department of Energy Contract No. DE-AC02-07CH11359

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157. Fast photon-detection for COMPASS RICH-1

Author

P. Abbon, M. Alexeev, H. Angerer, R. Birsa, P. Bordalo, F. Bradamante, A. Bressan, M. Chiosso, P. Ciliberti, M. L. Colantoni, T. Dafni, S. Dalla Torre, E. Delagnes, O. Denisov, H. Deschamps, V. Diaz, N. Dibiase, V. Duic, W. Eyrich, A. Ferrero, M. Finger, H. Fisher, S. Gerassimov, M. Giorgi, B. Gobbo, R. Hagemann, D. vonHarrac, F. H. Heinsius, R. Joosten, B. Ketzer, K. Königsmann, V. N. Kolosov, I. Konorov, D. Kramer, F. Kunne, A. Lehmann, S. Levorato, A. Maggiora, A. Magnon, A. Mann, A. Martin, G. Menon, A. Mutter, O. Nähle, D. Neyret, F. Nerling, S. Panebianco, D. Panzieri, S. Paul, G. Pesaro, C. Pizzolotto, J. Polak, P. Rebourgeard, F. Robinet, E. Rocco, P. Schiavon, C. Schill, W. Schoenmeier, W. Schröder, L. Silva, M. Sluneckai, F. Sozzi, L. Steiger, M. Sulc, M. Svec, F. Tessarotto, A. Teufel, and H. Wollny

Subjects
Physics, Optics, business.industry, Compass, business, Photon detection, Particle identification

158. Axion helioscopes update: The status of CAST & IAXO

Author

F.J. Iguaz and T. Dafni

Subjects
Physics, Particle physics, Helioscope, Physics - Instrumentation and Detectors, Dark matter, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 7. Clean energy, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Upgrade, Orders of magnitude (time), Observatory, Invariant mass, Detectors and Experimental Techniques, CERN Axion Solar Telescope, Astrophysics - Instrumentation and Methods for Astrophysics, Axion, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

Almost 35 years since their suggestion as a good solution to the strong CP-problem, axions remain one of the few viable candidates for the Dark Matter, although still eluding detection. Most of the methods for their detection are based on their coupling to photons, one of the most sensitive ones being the helioscope technique. We report on the current status of the CERN Axion Solar Telescope and the future International Axion Observatory (IAXO). Recent results from the second part of CAST phase II, where the magnet bores were filled with 3He gas at variable pressure achieving sensibilities on the axion mass up to 1.2 eV, are presented. Currently, CAST is expecting to improve its sensitivity to solar axions with rest mass below 0.02 eV/c^2 after the upgrade of the X-ray detectors and with the implementation of a second X-ray optic. At the same time, it is exploring other possibilities at the low energy physics frontier. On the other hand IAXO, the fourth generation axion helioscope, aims to improve CAST's performance in terms of axion-photon coupling by 1-1.5 orders of magnitude. The details of the project building a dedicated magnet, optics and X-ray detectors are given., Proceedings of 3rd International Conference on Technology and Instrumentation in Particle Physics (TIPP 2014)

159. Ionization and scintillation of nuclear recoils in gaseous xenon

Author

G. Luzón, Roberto Palma, F.J. Iguaz, J. M. Hauptman, N. Yahlali, A. Tomás, Hector Gomez, M. Sorel, Romain Esteve, A.L. Ferreira, A. Cervera, I. G. Irastorza, M. Nebot-Guinot, M. Losada, J. S. Díaz, Z. Tsamalaidze, F.J. Mora, Luis M. Serra, J.F. Toledo, S. Cárcel, L. Segui, J.J. Gómez-Cadenas, C.M.B. Monteiro, D. R. Nygren, J. Martin-Albo, F. Monrabal, C.A.N. Conde, Ana M. Gil, Gabriela Navarro, Diego González-Díaz, A. Marí, H. Natal da Luz, L.M.P. Fernandes, M. Monserrate, C. Sofka, J. A. M. Lopes, D.C. Herrera, Víctor H. Alvarez, Ana Martínez, Javier Pérez, V. M. Gehman, M A Jinete, José Villar, J. F. Castel, J. A. Hernando Morata, J. Muñoz Vidal, F.I.G.M. Borges, A. Goldschmidt, F.P. Santos, L.M. Moutinho, J. Torrent, D. Shuman, J Renner, J. T. White, J.L. Pérez Aparicio, J.M.F. dos Santos, T. Miller, T.H.V.T. Dias, A Rodríguez, L. Ripoll, Roberto Gutiérrez, I. Liubarsky, Carlos R. Oliveira, T. Dafni, J.F.C.A. Veloso, E.D.C. Freitas, Paola Ferrario, A. Laing, L. Labarga, Javier Rodríguez, H. S. Matis, A. Moiseenko, D. Lorca, S. Cebrián, Y. Nakajima, R. C. Webb, A. Simón, and Petr Evtoukhovitch

Subjects
MECANICA DE LOS MEDIOS CONTINUOS Y TEORIA DE ESTRUCTURAS, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, WIMP, Physics::Instrumentation and Detectors, Nuclear Theory, FOS: Physical sciences, chemistry.chemical_element, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, TECNOLOGIA ELECTRONICA, Nuclear physics, High Energy Physics - Experiment (hep-ex), Recoil, Xenon, Ionization, High pressure xenon gas, 0103 physical sciences, Dark matter, Nuclear recoils, Physics::Atomic and Molecular Clusters, Neutron, Physics::Atomic Physics, Nuclear Experiment (nucl-ex), Neutrinoless double beta decay, 010306 general physics, Nuclear Experiment, Instrumentation, Physics, Scintillation, Time projection chamber, 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), chemistry, Scintillation counter, Neutron source
Abstract

Ionization and scintillation produced by nuclear recoils in gaseous xenon at approximately 14 bar have been simultaneously observed in an electroluminescent time projection chamber. Neutrons from radioisotope α-Be neutron sources were used to induce xenon nuclear recoils, and the observed recoil spectra were compared to a detailed Monte Carlo employing estimated ionization and scintillation yields for nuclear recoils. The ability to discriminate between electronic and nuclear recoils using the ratio of ionization to primary scintillation is demonstrated. These results encourage further investigation on the use of xenon in the gas phase as a detector medium in dark matter direct detection experiments., This work was supported by the following agencies and institutions: the Director, Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy, and the National Energy Research Scientific Computing Center (NERSC), supported by the Office of Science of the U.S. Department of Energy, both under Contract no. DE-AC02-05CH11231; the European Research Council under the Advanced Grant 339787-NEXT; the Ministerio de Economia y Competitividad of Spain under Grants CONSOLIDER-Ingenio 2010 C5D2008-0037 (CUP), FPA2009-13697-004-04, FPA2009-13697-C04-01, FIS2012-37947-C04-01, FIS2012-37947-C04-02, FIS2012-37947-C04-03, and FIS2012-37947-C04-04; and the Portuguese FCT and FEDER through the program COMPETE, Projects PTDC/FIS/103860/2008 and PTDC/FIS/112272/2009. J. Renner acknowledges the support of a Department of Energy National Nuclear Security Administration Stewardship Science Graduate Fellowship, grant number DE-FC52-08NA28752.

160. Cast - A cern experiment to search for solar axions

Author

G. Lutz, E. Arik, D. Kang, J. Vogel, Javier Galan, Spyros Tzamarias, I. G. Irastorza, Heinrich Bräuninger, Serkant Ali Cetin, A. Belov, B. Beltrán, K. Barth, G. Luzón, Dieter Hoffmann, L. Di Lella, Yannis K. Semertzidis, J. Franz, F. H. Heinsius, A. Nordt, I. Hikmet, Georgios Fanourakis, M. Davenport, Konstantinos Kousouris, Milica Krčmar, M. J. Pivovaroff, Rainer Kotthaus, Konstantin Zioutas, J. M. Carmona, S. Aune, F. S. Boydag, T. Papaevangelou, T. Geralis, G. Bourlis, J. Ruz, D. J. Miller, I. Giomataris, I. Savvidis, Krešimir Jakovčić, A. Ortiz, K. Königsmann, Adriane De Assis Lawisch Rodriguez, D. Autiero, H. Fischer, C. Eleftheriadis, Regina Soufli, J. Morales, L. Stewart, O. B. Dogan, Louis Walckiers, T. Dafni, J. I. Collar, Markus Kuster, E. Ferrer-Ribas, M. D. Hasinoff, C. Lasseur, Hector Gomez, Pasquale D. Serpico, Georg G. Raffelt, A. Placci, José Villar, K. van Bibber, Ante Ljubičić, A. Morales, S. Cebrián, Biljana Lakić, A. Liolios, H. Riege, Joachim Jacoby, Sergei Gninenko, Doğuş Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, TR3959, and Belirlenecek

Subjects
Physics, Particle physics, Large Hadron Collider, Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, Dark matter, Particle identification, law.invention, Telescope, High Energy Physics::Theory, Axion, law, Dark Matter, Astronomical telescopes, Solar Particles and Photons
Abstract

The CAST experiment at CERN is the only running solar axion telescope. The first results obtained so far with CAST - PHASE I is presented, which compete with the best astrophysically derived limits of the axion-to-photon coupling. The ongoing PHASE II of the experiment as well as the scheduled upgrades, which improve the axion discovery potential of CAST, are discussed. Baklan Physical Uniaon; Türk Fizik Derneği; İstanbul Üniversitesi; Yıldız Teknik Üniversitesi.

161. Improved search for solar chameleons with a GridPix detector at CAST

Author

Wolfgang Funk, Milica Krčmar, T. Geralis, M. Maroudas, S. C. Yildiz, I. G. Irastorza, Joachim Jacoby, Sofia Kostoglou, Babette Döbrich, Sergei Gninenko, Giovanni Cantatore, C. Krieger, Søren Schmidt, M. Davenport, Marin Karuza, I. Ortega, M. J. Pivovaroff, Konstantin Zioutas, C. J. Hailey, J. Ruz, S. Neff, L. Miceli, T. Papaevangelou, S. Aune, Georg G. Raffelt, T. Dafni, I. Savvidis, M. Vretenar, Klaus Kurt Desch, Biljana Lakić, A. Liolios, Georgios Fanourakis, Nenad Kralj, Alexander Dermenev, J. F. Castel, A. Belov, Krešimir Jakovčić, L. Stewart, Dieter Hoffmann, Sami K. Solanki, Heinrich Bräuninger, Serkant Ali Cetin, E. Ruiz Chóliz, F.J. Iguaz, Vassilis Anastassopoulos, H. Fischer, A. Gardikiotis, Yannis K. Semertzidis, M. D. Hasinoff, C. Eleftheriadis, Jochen Kaminski, Anders Clemen Jakobsen, K. Paraschou, E. Ferrer-Ribas, J. M. Carmona, Julia Vogel, Theodoros Vafeiadis, J. G. Garza, K. Barth, G. Luzón, Walter Wuensch, I. Giomataris, M. Rosu, P. Brax, Ante Ljubičić, J. M. Laurent, J. A. Garcia, Evangelos Gazis, Finn Erland Christensen, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), CAST, Anastassopoulos, V., Aune, S., Barth, K., Belov, A., Bräuninger, H., Cantatore, G., Carmona, J. M., Castel, J. F., Cetin, S. A., Christensen, F., Dafni, T., Davenport, M., Dermenev, A., Desch, K., Döbrich, B., Eleftheriadis, C., Fanourakis, G., Ferrer-Ribas, E., Fischer, H., Funk, W., García, J. A., Gardikiotis, A., Garza, J. G., Gazis, E. N., Geralis, T., Giomataris, I., Gninenko, S., Hailey, C. J., Hasinoff, M. D., Hoffmann, D. H. H., Iguaz, F. J., Irastorza, I. G., Jakobsen, A., Jacoby, J., Jakovčić, K., Kaminski, J., Karuza, M., Kostoglou, S., Kralj, N., Krčmar, M., Krieger, C., Lakić, B., Laurent, J. M., Liolios, A., Ljubičić, A., Luzón, G., Maroudas, M., Miceli, L., Neff, S., Ortega, I., Papaevangelou, T., Paraschou, K., Pivovaroff, M. J., Raffelt, G., Rosu, M., Ruz, J., Chóliz, E. Ruiz, Savvidis, I., Schmidt, S., Semertzidis, Y. K., Solanki, S. K., Stewart, L., Vafeiadis, T., Vogel, J. K., Vretenar, M., Wuensch, W., Yildiz, S. C., Zioutas, K., and Brax, P.

Subjects
Physics - Instrumentation and Detectors, Photon, Physics::Instrumentation and Detectors, Solar luminosity, magnetic field, Astrophysics, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), photon: coupling, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Astrophysics::Solar and Stellar Astrophysics, Detectors and Experimental Techniques, GridPix, dark energy, modified gravity, physics.ins-det, Solar physics, Physics, dark energy experiments, particle physics - cosmology connection, solar physics, Astronomy and Astrophysics, chameleon: solar, solar physic, Instrumentation and Detectors (physics.ins-det), Coupling (probability), transition: (axion photon), dark energy experiment, Beta (plasma physics), Physics::Space Physics, CAST, Astrophysics::Earth and Planetary Astrophysics, CERN Axion Solar Telescope, Particle Physics - Experiment, chameleon, Modified gravity, Particle physics, CERN Lab, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, photon: spectrum, coupling constant: upper limit, Tachocline, Astrophysics::Cosmology and Extragalactic Astrophysics, X-ray, Dark energy experiments, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Sensitivity (control systems), hep-ex, background, 010308 nuclear & particles physics, magnet, coupling: (axion 2photon), Particle physics - cosmology connection, axion: solar, tachocline, Energy (signal processing), experimental results
Abstract

We report on a new search for solar chameleons with the CERN Axion Solar Telescope (CAST). A GridPix detector was used to search for soft X-ray photons in the energy range from 200 eV to 10 keV from converted solar chameleons. No signiffcant excess over the expected background has been observed in the data taken in 2014 and 2015. We set an improved limit on the chameleon photon coupling, $\beta_\gamma < 5.7\times10^{10}$ for $1, Comment: 19 pages, 12 figures, 3 tables

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164. The IAXO Helioscope.

Author

E Ferrer Ribas, E Armengaud, F T. Avignone, M Betz, P Brax, P Brun, G Cantatore, J M. Carmona, G P Carosi, F Caspers, S Caspi, S A Cetin, D Chelouche, F E Christensen, A Dael, T Dafni, M Davenport, A V Derbin, K Desch, and A Diago

Published
2015
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166. Low Background Micromegas in CAST.

Author

J G Garza, S Aune, F Aznar, D Calvet, J F Castel, F E Christensen, T Dafni, M Davenport, T Decker, E Ferrer-Ribas, J Galán, J A García, I Giomataris, R M Hill, F J Iguaz, I G Irastorza, A C Jakobsen, D Jourde, H Mirallas, and I Ortega

Published
2015
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167. Search for Solar Axions by the CERN Axion Solar Telescope with He3 Buffer Gas: Closing the Hot Dark Matter Gap

Author

Arik, M., Aune, S., Barth, K., Belov, A., Borghi, S., Brauninger, H., Cantatore, Giovanni, Carmona, J. M., Cetin, S. A., Da Riva, J. I. Collar E., Dafni, T., Davenport, M., Eleftheriadis, C., Elias, N., Fanourakis, G., Ferrer Ribas, E., Friedrich, P., Galan, J., Garcia, J. A., Gardikiotis, A., Garza, J. G., Gazis, E. N., Geralis, T., Georgiopoulou, E., Giomataris, I., Gninenko, S., Gomez, H., Gomez Marzoa, M., Gruber, E., Guthorl, T., Hartmann, R., Hauf, S., Haug, F., Hasinoff, M. D., Hoffmann, D. H. H., Iguaz, F. J., Irastorza, I. G., Jacoby, J., Jakovcic, K., Karuza, M., Konigsmann, K., Kotthaus, R., Krcmar, M., Kuster, M., Lakic, B., Lang, P. M., Laurent, J. M., Liolios, A., Ljubicic, A., Lozza, V., Luzon, G., Neff, S., Niinikoski, T., Nordt, A., Papaevangelou, T., Pivovaroff, M. J., Raffelt, G., Riege, H., Rodriguez, A., Rosu, M., Ruz, J., Savvidis, I., Shilon, I., Silva, P. S., Solanki, S. K., Stewart, L., Tomas, A., Tsagri, M., van Bibber, K., Vafeiadis, T., Villar, J., Vogel, J. K., Yildiz, S. C., Zioutas, K., M., Arik, S., Aune, K., Barth, A., Belov, S., Borghi, H., Brauninger, Cantatore, Giovanni, J. M., Carmona, S. A., Cetin, J. I. Collar E., Da Riva, T., Dafni, M., Davenport, C., Eleftheriadi, N., Elia, G., Fanouraki, E., Ferrer Riba, P., Friedrich, J., Galan, J. A., Garcia, A., Gardikioti, J. G., Garza, E. N., Gazi, T., Gerali, E., Georgiopoulou, I., Giomatari, S., Gninenko, H., Gomez, M., Gomez Marzoa, E., Gruber, T., Guthorl, R., Hartmann, S., Hauf, F., Haug, M. D., Hasinoff, D. H. H., Hoffmann, F. J., Iguaz, I. G., Irastorza, J., Jacoby, K., Jakovcic, M., Karuza, K., Konigsmann, R., Kotthau, M., Krcmar, M., Kuster, B., Lakic, P. M., Lang, J. M., Laurent, A., Liolio, A., Ljubicic, V., Lozza, G., Luzon, S., Neff, T., Niinikoski, A., Nordt, T., Papaevangelou, M. J., Pivovaroff, G., Raffelt, H., Riege, A., Rodriguez, M., Rosu, J., Ruz, I., Savvidi, I., Shilon, P. S., Silva, S. K., Solanki, L., Stewart, A., Toma, M., Tsagri, K., van Bibber, T., Vafeiadi, J., Villar, J. K., Vogel, S. C., Yildiz, and K., Zioutas

Subjects
solar axions, dark matter, Photon detection, solar axion, Physics::Instrumentation and Detectors, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics
Abstract

The CERN Axion Solar Telescope (CAST) has finished its search for solar axions with 3^He buffer gas, covering the search range 0.64 eV < m_a

Published
2014

168. The International Axion Observatory (IAXO)

Author

Irastorza, I. G., Avignone, F. T., Galan, J., Garcia, J. A., Geralis, T., Giomataris, I., Gninenko, S., Gomez, H., Hoffmann, D. H. H., Iguaz, F. J., Jakovcic, K., Krcmar, M., Cantatore, G., Lakic, B., Luzon, G., Lindner, A., Pivovaroff, M., Papaevangelou, T., Raffelt, G., Redondo, J., Rodriguez, A., Russenschuck, S., Ruz, J., Caspi, S., Shilon, I., Ten Kate, H., Tomas, A., Troitsky, S., van Bibber, K., Villar, J. A., Vogel, J., Walckiers, L., Zioutas, K., IAXO Collaboration, Carmona, J. M., Dafni, T., Davenport, M., Dudarev, A., Fanourakis, G., Ferrer-Ribas, E., Lindner A., Zioutas K., I. G., Irastorza, F. T., Avignone, Cantatore, Giovanni, S., Caspi, J. M., Carmona, T., Dafni, M., Davenport, A., Dudarev, G., Fanouraki, E., Ferrer Riba, J., Galan, J. A., Garcia, T., Gerali, I., Giomatari, S., Gninenko, H., Gomez, D. H. H., Hoffmann, F. J., Iguaz, K., Jakovcic, M., Krcmar, B., Lakic, G., Luzon, A., Lindner, M., Pivovaroff, T., Papaevangelou, G., Raffelt, J., Redondo, A., Rodrıguez, S., Russenschuck, J., Ruz, I., Shilon, H., Ten Kate, A., Toma, S., Troitsky, K., van Bibber, J. A., Villar, J., Vogel, L., Walckier, and K., Zioutas

Subjects
WISPs, WISP, WIMP, Axions, Physics, FOS: Physical sciences, magnetic field, coupling [photon axion], WIMPs, dark matter, astroparticle physics, High Energy Physics - Experiment, detector [axion], High Energy Physics - Experiment (hep-ex), Axion, low [background], Particle Physics - Experiment
Abstract

The International Axion Observatory (IAXO) is a new generation axion helioscope aiming at a sensitivity to the axion-photon coupling of g(alpha gamma) >~ few x 10-12 GeV**-1}, i.e. 1 - 1.5 orders of magnitude beyond the one currently achieved by CAST. The project relies on improvements in magnetic field volume together with extensive use of x-ray focusing optics and low background detectors, innovations already successfully tested in CAST. Additional physics cases of IAXO could include the detection of electron-coupled axions invoked to explain the white dwarf cooling, relic axions, and a large variety of more generic axion-like particles (ALPs) and other novel excitations at the low-energy frontier of elementary particle physics. This contribution is a summary of our recent paper \cite{Irastorza:2011gs}., Proc. of Patras Workshop on Axions, WIMPs and WISPs, 98 - 101; DESY-PROC-2011-04; ISSN 1435-8077

Published
2012
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169. CAST: Status and latest results

Author

Dafni, T., Aune, S., Davenport, M., Eleftheriadis, C., Elias, N., Ezer, C., Fanourakis, G., Ferrer-Ribas, E., Friedrich, P., Galan, J., Garcia, J. A., Gardikiotis, A., Barth, K., Gazis, E. N., Geralis, T., Giomataris, I., Gninenko, S., Gomez, H., Gruber, E., Guthorl, T., Hartmann, R., Haug, F., Hasinoff, M. D., Belov, A., Hoffmann, D. H. H., Iguaz, F. J., Irastorza, I. G., Jacoby, J., Jakovcic, K., Karuza, M., Konigsmann, K., Kotthaus, R., Krcmar, M., Kuster, M., Borghi, S., Lakic, B., Laurent, J. M., Liolios, A., Ljubicic, A., Lozza, V., Lutz, G., Luzon, G., Morales, J., Niinikoski, T., Nordt, A., Brauninger, H., Papaevangelou, T., Pivovaroff, M. J., Raffelt, G., Rashba, T., Riege, H., Rodriguez, A., Rosu, M., Ruz, J., Savvidis, I., Silva, P. S., Cantatore, G., Solanki, S. K., Stewart, L., Tomas, A., Tsagri, M., van Bibber, K., Vafeiadis, T., Villar, J., Vogel, J. K., Yildiz, S. C., Zioutas, K., Carmona, J. M., CAST Collaboration, Cetin, S. A., Collar, J. I., K. Zioutas, M. Schumann, T., Dafni, S., Aune, K., Barth, A., Belov, S., Borghi, H., Brauninger, Cantatore, Giovanni, J. M., Carmona, S. A., Cetin, J. I., Collar, M., Davenport, C., Eleftheriadi, N., Elia, C., Ezer, G., Fanouraki, E., Ferrer Riba, P., Friedrich, J., Galan, J. A., Garcia, A., Gardikioti, E. N., Gazi, T., Gerali, I., Giomatari, S., Gninenko, H., Gomez, E., Gruber, T., Guthorl, R., Hartmann, F., Haug, M. D., Hasinoff, D. H. H., Hoffmann, F. J., Iguaz, I. G., Irastorza, J., Jacoby, K., Jakovcic, M., Karuza, K., Konigsmann, R., Kotthau, M., Krcmar, M., Kuster, B., Lakic, J. M., Laurent, A., Liolio, A., Ljubicic, V., Lozza, G., Lutz, G., Luzon, J., Morale, T., Niinikoski, A., Nordt, T., Papaevangelou, M. J., Pivovaroff, G., Raffelt, T., Rashba, H., Riege, A., Rodriguez, M., Rosu, J., Ruz, I., Savvidi, P. S., Silva, S. K., Solanki, L., Stewart, A., Toma, M., Tsagri, K., van Bibber, T., Vafeiadi, J., Villar, J. K., Vogel, S. C., Yildiz, and K., Zioutas

Subjects
WISPs, solar axion, WISP, Physics, photon detectors, solar axions
Abstract

In July 2011, CAST finished the data-taking of its nominal programme, having scanned axion masses up to ~1.18 eV/c**2. Here we present the first results of the data taken in 2008, first year of the last data-taking campaign when $^3$He was used inside the magnet bores. No excess of signal over background has been recorded, and an upper limit has been set to the axion-to-photon coupling to 2.3*10**-10 GeV**-1 for axion masses between 0.39 and 0.64 eV. CAST remains the most sensitive axion helioscope and for the first time crosses the benchmark line of the KSVZ model at the upper end of the spectrum., Proc. of Patras Workshop on Axions, WIMPs and WISPs, 93 - 97; DESY-PROC-2011-04; ISSN 1435-8077

Published
2011
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170. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates

Author

Lorena Ramírez, Elisabet Viayna, Nicolas Isambert, M. Victòria Clos, Tània Gómez, Carles Galdeano, Albert Badia, Rodolfo Lavilla, Pelayo Camps, Diego Muñoz-Torrero, F. Javier Luque, Manuela Bartolini, Oscar Huertas, Francesca Mancini, Vincenza Andrisano, Elena Gómez, Thomai Dafni, Xavier Formosa, Axel Bidon-Chanal, P. Camp, X. Formosa, C. Galdeano, T. Gómez, D. Muñoz-Torrero, L. Ramírez, E. Viayna, E. Gómez, N. Isambert, R. Lavilla, A. Badia, M.V. Clo, M. Bartolini, F. Mancini, V. Andrisano, A. Bidon-Chanal, O. Huerta, T. Dafni, and F.J. Luque

Subjects
Models, Molecular, Stereochemistry, Amino Acid Motifs, Peptide, Toxicology, chemistry.chemical_compound, Piperidines, Alzheimer Disease, Catalytic Domain, Drug Discovery, medicine, Moiety, Aspartic Acid Endopeptidases, Humans, Donepezil, Binding site, Protein Structure, Quaternary, chemistry.chemical_classification, Amyloid beta-Peptides, biology, Active site, General Medicine, Acetylcholinesterase, chemistry, Biochemistry, Tacrine, Indans, biology.protein, Quinolines, Cholinesterase Inhibitors, Amyloid Precursor Protein Secretases, Protein Multimerization, Linker, medicine.drug
Abstract

Two novel families of dual binding site acetylcholinesterase (AChE) inhibitors have been developed, consisting of a tacrine or 6-chlorotacrine unit as the active site interacting moiety, either the 5,6-dimethoxy-2-[(4-piperidinyl)methyl]-1-indanone fragment of donepezil (or the indane derivative thereof) or a 5-phenylpyrano[3,2-c]quinoline system, reminiscent to the tryciclic core of propidium, as the peripheral site interacting unit, and a linker of suitable length as to allow the simultaneous binding at both sites. These hybrid compounds are all potent and selective inhibitors of human AChE, and more interestingly, are able to interfere in vitro both formation and aggregation of the beta-amyloid peptide, the latter effects endowing these compounds with the potential to modify Alzheimer's disease progression.

Published
2010

171. Measurement of the Longitudinal Spin Transfer to Lambda and Anti-Lambda Hyperons in Polarised Muon DIS

Author

Alekseev, M., Alexakhin, V. Y. u., Alexandrov, Y. u., Alexeev, G. D., Amoroso, A., Austregisilio, A., Badelek, B., Balestra, F., Ball, J., Barth, J., Baum, G., Bedfer, Y., Bernhard, J., Bertini, R., Bettinelli, M., Birsa, Renato, Bisplinghoff, J., Bordalo, P., Bradamante, Franco, Bravar, A., Bressan, Andrea, Brona, G., Burtin, E., Bussa, M. P., Chapiro, A., Chiosso, M., Chung, S. U., Cicuttin, A., Colantoni, M., Crespo, M. L., DALLA TORRE, Silvia, Dafni, T., Das, S., Dasgupta, S. S., Denisov, O. Y. u., Dhara, L., Diaz, V., Dinkelbach, A. M., Donskov, S. V., Doshita, N., Duic, Venicio, Dunnweber, W., Efremov, A., El Alaoui, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Fischer, H., Franco, C., Friedrich, J. M., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gazda, R., Gerassimov, S., Geyer, R., Giorgi, Marcello, Gobbo, B., Goertz, S., Grabmuller, S., Grajek, O. A., Grasso, A., Grube, B., Gushterski, R., Guskov, A., Haas, F., Hagemann, R., von Harrach, D., Hasegawa, T., Heckmann, J., Heinsius, F. H., Hermann, R., Herrmann, F., Hess, C., Hinterberger, F., Horikawa, N., Hoppner, C. h., D'Hose, N., Ilgner, C., Ishimoto, S., Ivanov, O., Ivanshin, Y. u., Iwata, T., Jahn, R., Jasinski, P., Jegou, G., Joosten, R., Kabuss, E., Kafer, W., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Y. u. A., Kiefer, J., Kisselev, Y. u., Klein, F., Klimaszewski, K., Koblitz, S., Koivuniemi, J. H., Kolosov, V. N., Komissarov, E. V., Kondo, K., Konigsmann, K., Konopka, R., Konorov, I., Konstantinov, V. F., Korzenev, A., Kotzinian, A. M., Kouznetsov, O., Kowalik, K., Kramer, M., Kral, A., Kroumchtein, Z. V., Kuhn, R., Kunne, F., Kurek, K., Le Goff, J. M., Lednev, A. A., Lehmann, A., Levorato, Stefano, Lichtenstadt, J., Liska, T., Maggiora, A., Maggiora, M., Magnon, A., Mallot, G. K., Mann, A., Marchand, C., Marroncle, J., Martin, Anna, Marzec, J., Massmann, F., Matsuda, T., Maximov, A. N., Meyer, W., Michigami, T., Mikhailov, Y. u. V., Moinester, M. A., Mutter, A., Nagaytsev, A., Nagel, T., Nassalski, J., Negrini, S., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Olshevsky, A. G., Ostrick, M., Padee, A., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pawlukiewicz Kaminska, B., Perevalova, E., Pesaro, Giulia, Peshekhonov, D. V., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pontecorvo, G., Pretz, J., Quintans, C., Rajotte, J. F., Ramos, S., Rapatsky, V., Reicherz, G., Reggiani, D., Richter, A., Robinet, F., Rocco, E., Rondio, E., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Santos, H., Sapozhnikov, M. G., Sarkar, S., Savin, I. A., Sbrizzai, Giulio, Schiavon, Paolo, Schill, C., Schmitt, L., Schroder, W., Shevchenko, O. Y. u., Siebert, H. W., Silva, L., Sinha, L., Sissakian, A. N., Slunecka, M., Smirnov, G. I., Sosio, S., Sozzi, Federica, Srnka, A., Stolarski, M., Sulc, M., Sulej, R., Takekawa, Stefano, Tessaro, Susanna, Tessarotto, F., Teufel, A., Tkatchev, L. G., Venugopal, G., Virius, M., Vlassov, N. V., Vossen, A., Weitzel, Q., Wenzl, K., Windmolders, R., Wislicki, W., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., Zhao, J., Zhuravlev, N., Zvyagin, A., M., Alekseev, Alexakhin, V. Y. u., Alexandrov, Y. u., G. D., Alexeev, A., Amoroso, A., Austregisilio, B., Badelek, F., Balestra, J., Ball, J., Barth, G., Baum, Y., Bedfer, J., Bernhard, R., Bertini, M., Bettinelli, Birsa, Renato, J., Bisplinghoff, P., Bordalo, Bradamante, Franco, A., Bravar, Bressan, Andrea, G., Brona, E., Burtin, M. P., Bussa, A., Chapiro, M., Chiosso, S. U., Chung, A., Cicuttin, M., Colantoni, M. L., Crespo, DALLA TORRE, Silvia, T., Dafni, S., Da, S. S., Dasgupta, Denisov, O. Y. u., L., Dhara, V., Diaz, A. M., Dinkelbach, S. V., Donskov, N., Doshita, Duic, Venicio, W., Dunnweber, A., Efremov, A., El Alaoui, P. D., Eversheim, W., Eyrich, M., Faessler, A., Ferrero, M., Finger, H., Fischer, C., Franco, J. M., Friedrich, R., Garfagnini, F., Gautheron, O. P., Gavrichtchouk, R., Gazda, S., Gerassimov, R., Geyer, Giorgi, Marcello, B., Gobbo, S., Goertz, S., Grabmuller, O. A., Grajek, A., Grasso, B., Grube, R., Gushterski, A., Guskov, F., Haa, R., Hagemann, D., von Harrach, T., Hasegawa, J., Heckmann, F. H., Heinsiu, R., Hermann, F., Herrmann, C., He, F., Hinterberger, N., Horikawa, Hoppner, C. h., N., D'Hose, C., Ilgner, S., Ishimoto, O., Ivanov, Ivanshin, Y. u., T., Iwata, R., Jahn, P., Jasinski, G., Jegou, R., Joosten, E., Kabu, W., Kafer, D., Kang, B., Ketzer, G. V., Khaustov, Khokhlov, Y. u. A., J., Kiefer, Kisselev, Y. u., F., Klein, K., Klimaszewski, S., Koblitz, J. H., Koivuniemi, V. N., Kolosov, E. V., Komissarov, K., Kondo, K., Konigsmann, R., Konopka, I., Konorov, V. F., Konstantinov, A., Korzenev, A. M., Kotzinian, O., Kouznetsov, K., Kowalik, M., Kramer, A., Kral, Z. V., Kroumchtein, R., Kuhn, F., Kunne, K., Kurek, J. M., Le Goff, A. A., Lednev, A., Lehmann, Levorato, Stefano, J., Lichtenstadt, T., Liska, A., Maggiora, M., Maggiora, A., Magnon, G. K., Mallot, A., Mann, C., Marchand, J., Marroncle, Martin, Anna, J., Marzec, F., Massmann, T., Matsuda, A. N., Maximov, W., Meyer, T., Michigami, Mikhailov, Y. u. V., M. A., Moinester, A., Mutter, A., Nagaytsev, T., Nagel, J., Nassalski, S., Negrini, F., Nerling, S., Neubert, D., Neyret, V. I., Nikolaenko, A. G., Olshevsky, M., Ostrick, A., Padee, R., Panknin, D., Panzieri, B., Parsamyan, S., Paul, B., Pawlukiewicz Kaminska, E., Perevalova, Pesaro, Giulia, D. V., Peshekhonov, G., Piragino, S., Platchkov, J., Pochodzalla, J., Polak, V. A., Polyakov, G., Pontecorvo, J., Pretz, C., Quintan, J. F., Rajotte, S., Ramo, V., Rapatsky, G., Reicherz, D., Reggiani, A., Richter, F., Robinet, E., Rocco, E., Rondio, D. I., Ryabchikov, V. D., Samoylenko, A., Sandacz, H., Santo, M. G., Sapozhnikov, S., Sarkar, I. A., Savin, Sbrizzai, Giulio, Schiavon, Paolo, C., Schill, L., Schmitt, W., Schroder, Shevchenko, O. Y. u., H. W., Siebert, L., Silva, L., Sinha, A. N., Sissakian, M., Slunecka, G. I., Smirnov, S., Sosio, Sozzi, Federica, A., Srnka, M., Stolarski, M., Sulc, R., Sulej, Takekawa, Stefano, Tessaro, Susanna, F., Tessarotto, A., Teufel, L. G., Tkatchev, G., Venugopal, M., Viriu, N. V., Vlassov, A., Vossen, Q., Weitzel, K., Wenzl, R., Windmolder, W., Wislicki, H., Wollny, K., Zaremba, M., Zavertyaev, E., Zemlyanichkina, M., Ziembicki, J., Zhao, N., Zhuravlev, and A., Zvyagin

Subjects
Fragmentation into hadron, High Energy Physics - Experiment (hep-ex), Baryon production, Fragmentation into hadrons, Polarization in interactions and scattering, Hyperons, FOS: Physical sciences, High Energy Physics::Experiment, Particle Physics - Experiment, High Energy Physics - Experiment
Abstract

The longitudinal polarisation transfer from muons to lambda and anti-lambda hyperons, D_LL, has been studied in deep inelastic scattering off an unpolarised isoscalar target at the COMPASS experiment at CERN. The spin transfers to lambda and anti-lambda produced in the current fragmentation region exhibit different behaviours as a function of x and xF . The measured x and xF dependences of D^lambda_LL are compatible with zero, while D^anti-lambda_LL tends to increase with xF, reaching values of 0.4 - 0.5. The resulting average values are D^lambda_LL = -0.012 +- 0.047 +- 0.024 and D^anti-lambda_LL = 0.249 +- 0.056 +- 0.049. These results are discussed in the frame of recent model calculations., 13 pages, 7 figures

Published
2009

172. Search for low Energy solar Axions with CAST

Author

Cantatore, Giovanni, Arik, E., Aune, S., Autiero, D., Barth, K., Belov, A., Beltr��n, B., Borghi, S., Boydag, F. S., Br��uninger, H., Cantatore, G., Carmona, J. M., Cebri��n, S., Cetin, S. A., Collar, J. I., Dafni, T., Davenport, M., Di Lella, L., Dogan, O. B., Eleftheriadis, C., Elias, N., Fanourakis, G., Ferrer-Ribas, E., Fischer, H., Franz, J., Gal��n, J., Gazis, E., Geralis, T., Giomataris, I., Gninenko, S., G��mez, H., Hasinoff, M., Heinsius, F. H., Hikmet, I., Hoffmann, D. H. H., Irastorza, I. G., Jacoby, J., Jakov��i��, K., Kang, D., Karageorgopoulou, T., Karuza, M., K��nigsmann, K., Kotthaus, R., Kr��mar, M., Kousouris, K., Kuster, M., Laki��, B., Lasseur, C., Liolios, A., Ljubi��i��, A., Lozza, V., Lutz, G., Luz��n, G., Miller, D., Morales, A., {Deceased}, Morales, J., Niinikoski, T., Nordt, A., Ortiz, A., Papaevangelou, T., Pivovaroff, M., Placci, A., Raiteri, G., Raffelt, G., Riege, H., Rodr��guez, A., Ruz, J., Savvidis, I., Semertzidis, Y., Serpico, P., Solanki, S. K., Soufli, R., Stewart, L., Tsagri, M., van Bibber, K., Villar, J., Vogel, J., Walckiers, L., Zioutas, K., Lindner a., Redondo J., Ringwald A., Cantatore, Giovanni, FOR THE CAST COLLABORATION E., Arik, S., Aune, D., Autiero, K., Barth, A., Belov, B., Beltrán, S., Borghi, F. S., Boydag, H., Bräuninger, Cantatore, G., J. M., Carmona, S., Cebrián, S. A., Cetin, J. I., Collar, T., Dafni, M., Davenport, L., DI LELLA, O. B., Dogan, C., Eleftheriadi, N., Elia, G., Fanouraki, E., FERRER RIBAS, H., Fischer, J., Franz, J., Galán, E., Gazi, T., Gerali, I., Giomatari, S., Gninenko, H., Gómez, M., Hasinoff, F. H., Heinsiu, I., Hikmet, D. H. H., Hoffmann, I. G., Irastorza, J., Jacoby, K., Jakoväiä, D., Kang, T., Karageorgopoulou, M., Karuza, K., Königsmann, R., Kotthau, M., Krämar, K., Kousouri, M., Kuster, B., Lakiä, C., Lasseur, A., Liolio, A., Ljubiäiä, V., Lozza, G., Lutz, G., Luzón, D., Miller, A., Morale, Deceased, J., Morale, T., Niinikoski, A., Nordt, A., Ortiz, T., Papaevangelou, M., Pivovaroff, A., Placci, G., Raiteri, G., Raffelt, H., Riege, A., Rodríguez, J., Ruz, I., Savvidi, Y., Semertzidi, P., Serpico, S. K., Solanki, R., Soufli, L., Stewart, M., Tsagri, K., VAN BIBBER, J., Villar, J., Vogel, L., Walckier, and K., Zioutas

Subjects
WISPs, WISP, detector, Physics::Instrumentation and Detectors, Axions, Physics, FOS: Physical sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Axion, detectors, solar physics, Particle Physics - Experiment
Abstract

We have started the development of a detector system, sensitive to single photons in the eV energy range, to be suitably coupled to one of the CAST magnet ports. This system should open to CAST a window on possible detection of low energy Axion Like Particles emitted by the sun. Preliminary tests have involved a cooled photomultiplier tube coupled to the CAST magnet via a Galileian telescope and a switched 40 m long optical fiber. This system has reached the limit background level of the detector alone in ideal conditions, and two solar tracking runs have been performed with it at CAST. Such a measurement has never been done before with an axion helioscope. We will present results from these runs and briefly discuss future detector developments., Paper submitted to the proceedings of the "4th Patras Workshop on Axions, WIMPs and WISPs", DESY, Hamburg Site - Germany, 18-21 June 2008. Author affiliations are reported on the title page of the paper. In version 2: 1 affiliation change, 3 references added

Published
2009
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173. SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING OF A NOVEL FAMILY OF 6-CHLOROTACRINE-BASED DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS

Author

Galdeano, Caries, Camps, Pelayo, Formosa, Xavier, Munoz-Torrero, Diego, Ramirez, Lorena, Gomez, Elena, Isambert, Nicolas, Lavilla, Rodolfo, Badia, Albert, Victoria Clos, M., Bartolini, Manuela, Mancini, Francesca, Andrisano, Vincenza, Arce, Mariana P., Isabel Rodriguez-Franco, M., Huertos, Oscar, Dafni, Thomai, F. Javier Luque, C. Galdeano, P. Camp, X. Formosa, D. Muñoz-Torrero, L. Ramírez, E. Gómez, N. Isambert, R. Lavilla, A. Badia, M. V. Clo, M. Bartolini, F. Mancini, V. Andrisano, M. P. Arce, M. I. Rodríguez-Franco, Ó. Huerta, T. Dafni, F. J. Luque, ZRINKA KOVARIK, MAJA KATALINI&#262, AND GORAN ŠINKO, Galdeano C., Camps P., Formosa X., Muñoz-Torrero D., Ramírez L., Gómez E., Isambert N., Lavilla R., Badia A., Clos M.V., Bartolini M., Mancini F., Andrisano V., Arce M.P., Rodríguez-Franco M.I., Huertas O., Dafni T., and Luque F.J.

Subjects
ACETYLCHOLINESTERASE INHIBITORS, ANTI-ALZHEIMERDRUG CANDIDATES, ANTI-ALZHEIMER DRUG, GAMMA-SECRETASE INHIBITION, 6-CHLOROTACRINE DERIVATIVES, BETA-SECRETASE-1 INHIBITION, HUMAN ACHE INHIBITORS, BETA-AMYLOID AGGREGATION
Abstract

In the last decade, the design of novel classes of inhibitors of the enzyme acetylcholinesterase (AChE) as therapeutic interventions for Alzheimer’s disease (AD) has been mostly driven by the pivotal finding that AChE can bind the β-amyloid peptide (Aβ), thereby promoting Aβ aggregation as an early event in the neurodegenerative cascade of AD. Blockade of the peripheral site of AChE, the Aβ recognition zone within the enzyme, is expected to affect the AChE-induced Aβ aggregation and could be a potential strategy to modulate the progression of AD. Novel classes of AChE inhibitors (AChEIs) targeting the peripheral site of AChE are emerging as promising disease-modifying anti-Alzheimer drug candidates. Of particular interest are the so-called dual binding site AChEIs, i.e. inhibitors able to simultaneously bind both the active and peripheral sites of AChE, which exhibit significant Aβ antiaggregating effects and high AChE inhibitory potencies. Two isomeric series of dual binding site AChEIs have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced Aβ aggregation and β-secretase (BACE-1). The new hybrids consist of a unit of 6-chlorotacrine and a multicomponent reactionderived pyrano[3,2-c]quinoline scaffold as the active-site and peripheral-site interacting moieties, respectively, connected through an oligomethylene linker containing an amido group at variable position. Molecular modeling studies have confirmed the dual site binding of these hybrids, which retain the potent and selective human AChE inhibitory activity of the parent 6-chlorotacrine, while exhibiting a significant in vitro Aβ anti-aggregating effect and BACE-1 inhibitory activity, thus constituting promising anti-Alzheimerdrug candidates.

Published
2009

174. Double spin asymmetry in exclusive rho0 muoproduction at COMPASS

Author

Alekseev, M., Alexakhin, V. Y. U., Alexandrov, Y. U., Alexeev, G. D., Amoroso, A., Arbuzov, A., Badelek, B., Balestra, F., Ball, J., Barth, J., Baum, G., Bedfer, Y., Bernet, C., Bertini, R., Bettinelli, M., Birsa, R., Bisplinghoff, J., Bordalo, P., Bradamante, Franco, Bravar, A., Bressan, Andrea, Brona, G., Burtin, E., Bussa, M. P., Chapiro, A., Chiosso, M., Cicuttin, A., Colantoni, M., Costa, S., Crespo, M. L., DALLA TORRE, S., Dafni, T., Das, S., Dasgupta, S. S., DE MASSI, R., Dedek, N., Denisov, O. Y. U., Dhara, L., Diaz, V., Dinkelbach, A. M., Donskov, S. V., Dorofeev, V. A., Doshita, N., Duic, V., Dunnweber, W., Eversheim, P. D., Eyrich, W., Fabro, M., Faessler, M., Falaleev, V., Ferrero, A., Ferrero, L., Finger, M., Fischer, H., Franco, C., Franz, J., Friedrich, J. M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gazda, R., Gerassimov, S., Geyer, R., Giorgi, Marcello, Gobbo, B., Goertz, S., Gorin, A. M., Grabmuller, S., Grajek, O. A., Grasso, A., Grube, B., Gushterski, R., Guskov, A., Haas, F., Hannappel, J., VON HARRACH, D., Hasegawa, T., Heckmann, J., Hedicke, S., Heinsius, F. H., Hermann, R., Hess, C., Hinterberger, F., VON HODENBERG, M., Horikawa, N., Horikawa, S., D'Hose, N., Ilgner, C., Ioukaev, A. I., Ishimoto, S., Ivanov, O., Ivanshin, Y. U., Iwata, T., Jahn, R., Janata, A., Jasinski, P., Joosten, R., Jouravlev, N. I., Kabuss, E., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Y. U. A., Kisselev, Y. U., Klein, F., Klimaszewski, K., Koblitz, S., Koivuniemi, J. H., Kolosov, V. N., Komissarov, E. V., Kondo, K., Konigsmann, K., Konorov, I., Konstantinov, V. F., Korentchenko, A. S., Korzenev, A., Kotzinian, A. M., Koutchinski, N. A., Kouznetsov, O., Kral, A., Kravchuk, N. P., Kroumchtein, Z. V., Kuhn, R., Kunne, F., Kurek, K., Ladygin, M. E., Lamanna, M., LE GOFF, J. M., Lednev, A. A., Lehmann, A., Lichtenstadt, J., Liska, T., Ludwig, I., Maggiora, A., Maggiora, M., Magnon, A., Mallot, G. K., Mann, A., Marchand, C., Marroncle, J., Martin, Anna, Marzec, J., Massmann, F., Matsuda, T., Maximov, A. N., Meyer, W., Mielech, A., Mikhailov, Y. U. V., Moinester, M. A., Mutter, A., Nagaytsev, A., Nagel, T., Nahle, O., Nassalski, J., Neliba, S., Nerling, F., Neubert, S., Neyret, D. P., Nikolenko, V. I., Nikolaev, K., Olshevsky, A. G., Ostrick, M., Padee, A., Pagano, P., Panebianco, S., Panknin, R., Panzieri, D., Paul, S., PAWLUKIEWICZ KAMINSKA, B., Peshekhonov, D. V., Peshekhonov, V. D., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pretz, J., Procureur, S., Quintans, C., Rajotte, J. F., Ramos, S., Rapatsky, V., Reicherz, G., Richter, A., Robinet, F., Rocco, E., Rondio, E., Rozhdestvensky, A. M., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Santos, H., Sapozhnikov, M. G., Sarkar, S., Savin, I. A., Schiavon, Paolo, Schill, C., Schmitt, L., Schonmeier, P., Schroder, W., Shevchenko, O. Y. U., Siebert, H. W., Silva, L., Sinha, L., Sissakian, A. N., Slunecka, M., Smirnov, G. I., Sosio, S., Sozzi, F., Srnka, A., Stinzing, F., Stolarski, M., Sugonyaev, V. P., Sulc, M., Sulej, R., Tchalishev, V. V., Tessaro, S., Tessarotto, F., Teufel, A., Tkatchev, L. G., Venugopal, G., Virius, M., Vlassov, N. V., Vossen, A., Webb, R., Weise, E., Weitzel, Q., Windmolders, R., Wirth, S., Wislicki, W., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Zhao, J., Ziegler, R., Zvyagin, A., M., Alekseev, Alexakhin, V. Y. U., Alexandrov, Y. U., G. D., Alexeev, A., Amoroso, A., Arbuzov, B., Badelek, F., Balestra, J., Ball, J., Barth, G., Baum, Y., Bedfer, C., Bernet, R., Bertini, M., Bettinelli, R., Birsa, J., Bisplinghoff, P., Bordalo, Bradamante, Franco, A., Bravar, Bressan, Andrea, G., Brona, E., Burtin, M. P., Bussa, A., Chapiro, M., Chiosso, A., Cicuttin, M., Colantoni, S., Costa, M. L., Crespo, S., DALLA TORRE, T., Dafni, S., Da, S. S., Dasgupta, R., DE MASSI, N., Dedek, Denisov, O. Y. U., L., Dhara, V., Diaz, A. M., Dinkelbach, S. V., Donskov, V. A., Dorofeev, N., Doshita, V., Duic, W., Dunnweber, P. D., Eversheim, W., Eyrich, M., Fabro, M., Faessler, V., Falaleev, A., Ferrero, L., Ferrero, M., Finger, Jr, H., Fischer, C., Franco, J., Franz, J. M., Friedrich, V., Frolov, R., Garfagnini, F., Gautheron, O. P., Gavrichtchouk, R., Gazda, S., Gerassimov, R., Geyer, Giorgi, Marcello, B., Gobbo, S., Goertz, A. M., Gorin, S., Grabmuller, O. A., Grajek, A., Grasso, B., Grube, R., Gushterski, A., Guskov, F., Haa, J., Hannappel, D., VON HARRACH, T., Hasegawa, J., Heckmann, S., Hedicke, F. H., Heinsiu, R., Hermann, C., He, F., Hinterberger, M., VON HODENBERG, N., Horikawa, S., Horikawa, N., D'Hose, C., Ilgner, A. I., Ioukaev, S., Ishimoto, O., Ivanov, Ivanshin, Y. U., T., Iwata, R., Jahn, A., Janata, P., Jasinski, R., Joosten, N. I., Jouravlev, E., Kabu, D., Kang, B., Ketzer, G. V., Khaustov, Khokhlov, Y. U. A., Kisselev, Y. U., F., Klein, K., Klimaszewski, S., Koblitz, J. H., Koivuniemi, V. N., Kolosov, E. V., Komissarov, K., Kondo, K., Konigsmann, I., Konorov, V. F., Konstantinov, A. S., Korentchenko, A., Korzenev, A. M., Kotzinian, N. A., Koutchinski, O., Kouznetsov, A., Kral, N. P., Kravchuk, Z. V., Kroumchtein, R., Kuhn, F., Kunne, K., Kurek, M. E., Ladygin, M., Lamanna, J. M., LE GOFF, A. A., Lednev, A., Lehmann, J., Lichtenstadt, T., Liska, I., Ludwig, A., Maggiora, M., Maggiora, A., Magnon, G. K., Mallot, A., Mann, C., Marchand, J., Marroncle, Martin, Anna, J., Marzec, F., Massmann, T., Matsuda, A. N., Maximov, W., Meyer, A., Mielech, Mikhailov, Y. U. V., M. A., Moinester, A., Mutter, A., Nagaytsev, T., Nagel, O., Nahle, J., Nassalski, S., Neliba, F., Nerling, S., Neubert, D. P., Neyret, V. I., Nikolenko, K., Nikolaev, A. G., Olshevsky, M., Ostrick, A., Padee, P., Pagano, S., Panebianco, R., Panknin, D., Panzieri, S., Paul, B., PAWLUKIEWICZ KAMINSKA, D. V., Peshekhonov, V. D., Peshekhonov, G., Piragino, S., Platchkov, J., Pochodzalla, J., Polak, V. A., Polyakov, J., Pretz, S., Procureur, C., Quintan, J. F., Rajotte, S., Ramo, V., Rapatsky, G., Reicherz, A., Richter, F., Robinet, E., Rocco, E., Rondio, A. M., Rozhdestvensky, D. I., Ryabchikov, V. D., Samoylenko, A., Sandacz, H., Santo, M. G., Sapozhnikov, S., Sarkar, I. A., Savin, Schiavon, Paolo, C., Schill, L., Schmitt, P., Schonmeier, W., Schroder, Shevchenko, O. Y. U., H. W., Siebert, L., Silva, L., Sinha, A. N., Sissakian, M., Slunecka, G. I., Smirnov, S., Sosio, F., Sozzi, A., Srnka, F., Stinzing, M., Stolarski, V. P., Sugonyaev, M., Sulc, R., Sulej, V. V., Tchalishev, S., Tessaro, F., Tessarotto, A., Teufel, L. G., Tkatchev, G., Venugopal, M., Viriu, N. V., Vlassov, A., Vossen, R., Webb, E., Weise, Q., Weitzel, R., Windmolder, S., Wirth, W., Wislicki, K., Zaremba, M., Zavertyaev, E., Zemlyanichkina, J., Zhao, R., Ziegler, and A., Zvyagin

Subjects
Physics, Particle physics, Physics and Astronomy (miscellaneous), Meson, 010308 nuclear & particles physics, media_common.quotation_subject, FOS: Physical sciences, 01 natural sciences, Asymmetry, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Deuterium, Compass, 0103 physical sciences, High Energy Physics::Experiment, 010306 general physics, Engineering (miscellaneous), Particle Physics - Experiment, Spin-½, media_common
Abstract

The longitudinal double spin asymmetry A_1^rho for exclusive leptoproduction of rho^0 mesons, mu + N -> mu + N + rho, is studied using the COMPASS 2002 and 2003 data. The measured reaction is incoherent exclusive rho^0 production on polarised deuterons. The Q^2 and x dependence of A_1^rho is presented in a wide kinematical range: 3x10^-3 < Q^2 < 7 (GeV/c)^2 and 5x10^-5 < x < 0.05. The presented results are the first measurements of A_1^rho at small Q2 (Q2 < 0.1 (GeV/c)^2) and small x (x < 3x10^-3). The asymmetry is in general compatible with zero in the whole kinematical range., 6 Figures, 15 pages, version 2 with updated author list, technical latex problem fixed

Published
2007

175. Hartmann test of the COMPASS RICH-1 optical telescopes

Author

Abbon, P., Alekseev, M., Angerer, H., Apollonio, M., Birsa, R., Bordalo, P., Bradamante, F., Andrea Bressan, Busso, L., Chiosso, V. M., Ciliberti, P., Colantoni, M. L., Costa, S., Dibiase, N., Dafni, T., Torre, S. Dalla, Diaz, V., Duic, V., Delagnes, E., Deschamps, H., Eyrich, W., Faso, D., Ferrero, A., Finger, M., Fischer, H., Gerassimov, S., Giorgi, M., Gobbo, B., Hagemann, R., Harrach, D., Heinsius, F. H., Joosten, R., Ketzer, B., Koenigsmann, K., Kolosov, V. N., Konorov, I., Kramer, D., Kunne, F., Levorato, S., Maggiora, A., Magnon, A., Mann, A., Martin, A., Menon, G., Mutter, A., Naehle, O., Neyret, D., Nerling, F., Pagano, P., Paul, S., Panebianco, S., Panzieri, D., Pesaro, G., Pizzolotto, C., Polak, J., Rebourgeard, P., Rocco, E., Robinet, F., Schiavon, P., Schill, C., Schoenmeier, P., Silva, L., Slunecka, M., Steiger, L., Sozzi, F., Sulc, M., Svec, M., Tessarotto, F., Teufel, A., Wollny, H., P., Abbon, T., Dafni, E., Delagne, H., Deschamp, F., Kunne, A., Magnon, D., Neyret, S., Panebianco, P., Rebourgeard, F., Robinet, M., Alekseev, L., Busso, M., Chiosso, S., Costa, N., Dibiase, D., Faso, A., Ferrero, A., Maggiora, H., Angerer, S., Gerasimov, B., Ketzer, I., Konorov, A., Mann, S., Paul, M., Apollonio, R., Birsa, F., Bradamante, Bressan, Andrea, Ciliberti, Piero, S., DALLA TORRE, V., Diaz, V., Duic, M., Giorgi, B., Gobbo, Levorato, Stefano, Martin, Anna, G., Menon, P., Pagano, G., Pesaro, E., Rocco, Schiavon, Paolo, F., Sozzi, F., Tessarotto, P., Bordalo, L., Silva, M. L., Colantoni, D., Panzieri, W., Eyrich, C., Pizzolotto, P., Schonmeier, A., Teufel, M., Finger, M., Slunecka, H., Fischer, R., Hagemann, F. H., Heinsiu, K., Konigsmann, A., Mutter, F., Nerling, C., Schill, H., Wollny, D., VON HARRACH, R., Joosten, O., Nahle, V. N., Kolosov, D., Kramer, J., Polak, L., Steiger, M., Sulc, and M., Svec

Subjects
UV lenses, Hartmann test, Particle Physics - Experiment, COMPASS RICH1
Abstract

The central region of COMPASS RICH-1 has been equipped with a new photon detection system based on MultiAnode PhotoMultiplier Tubes (MAPMT). The Cherenkov photons are focused by an array of 576 fused silica telescopes onto 576 MAPMTs. The quality and positioning of all optical components have been tested by Hartmann method. The validation procedures are described. The quality of the optical concentrators was checked and alignment corrections were made. The upgraded detector showed excellent performances during 2006 data taking.

176. Fast photon detection for COMPASS RICH-1

Author

Abbon, P., Dafni, T., Delagnes, E., Deschamps, H., Kunne, F., Magnon, A., Neyret, D., Panebianco, S., Rebourgeard, P., Robinet, F., Alekseev, M., Busso, L., Chiosso, M., Costa, S., Di Biase, N., Faso, D., Ferrero, A., Maggiora, A., Angerer, H., Gerasimov, S., Ketzer, B., Konorov, I., Mann, A., Stephan Paul, Apollonio, M., Birsa, R., Bradamante, F., Bressan, A., Ciliberti, P., Dalla Torre, S., Diaz, V., Duic, V., Giorgi, M., Gobbo, B., Levorato, S., Martin, A., Menon, G., Pagano, P., Pesaro, G., Rocco, E., Schiavon, P., Sozzi, F., Tessarotto, F., Bordalo, P., Silva, L., Colantoni, M. L., Panzieri, D., Eyrich, W., Pizzolotto, C., Schonmeier, P., Teufel, A., Finger, M., Slunecka, M., Fischer, H., Hagemann, R., Heinsius, F. H., Konigsmann, Kay, Mutter, A., Nerling, F., Schill, C., Wollny, H., Harrach, D., Joosten, R., Nahle, O., Kolosov, V. N., Kramer, D., Polak, J., Steiger, L., Sulc, M., Svec, M., P., Abbon, T., Dafni, E., Delagne, H., Deschamp, F., Kunne, A., Magnon, D., Neyret, S., Panebianco, P., Rebourgeard, F., Robinet, M., Alekseev, L., Busso, M., Chiosso, S., Costa, N., DI BIASE, D., Faso, A., Ferrero, A., Maggiora, H., Angerer, S., Gerasimov, B., Ketzer, I., Konorov, A., Mann, S., Paul, M., Apollonio, R., Birsa, F., Bradamante, Bressan, Andrea, Ciliberti, Piero, S., DALLA TORRE, V., Diaz, V., Duic, M., Giorgi, B., Gobbo, Levorato, Stefano, Martin, Anna, G., Menon, P., Pagano, G., Pesaro, E., Rocco, Schiavon, Paolo, F., Sozzi, F., Tessarotto, P., Bordalo, L., Silva, M. L., Colantoni, D., Panzieri, W., Eyrich, C., Pizzolotto, P., Schonmeier, A., Teufel, M., Finger, M., Slunecka, H., Fischer, R., Hagemann, F. H., Heinsiu, K., Konigsmann, A., Mutter, F., Nerling, C., Schill, H., Wollny, D., VON HARRACH, R., Joosten, O., Nahle, V. N., Kolosov, D., Kramer, J., Polak, L., Steiger, M., Sulc, and M., Svec

Subjects
Multi-anode PMT, COMPASS RICH1, fused silica lens telescopes, Particle Physics - Experiment
Abstract

The new photon detection system for COMPASS RICH-1 has been designed to cope with the demanding requests of operation at high beam intensity and at high trigger rates. The detection technique in the central region of RICH-1 has been changed with a system based on multianode photomultipliers coupled to individual fused silica lens telescopes and to a fast, almost dead time free readout system based on the MAD-4 amplifier-discriminator and the F1 TDC-chip. The new photon detection system design and construction are described, as well as its first response in the experiment.

177. New Upper Limit on the Axion-Photon Coupling with an Extended CAST Run with a Xe-Based Micromegas Detector.

Author

Altenmüller K, Anastassopoulos V, Arguedas-Cuendis S, Aune S, Baier J, Barth K, Bräuninger H, Cantatore G, Caspers F, Castel JF, Çetin SA, Christensen F, Cogollos C, Dafni T, Davenport M, Decker TA, Desch K, Díez-Ibáñez D, Döbrich B, Ferrer-Ribas E, Fischer H, Funk W, Galán J, García JA, Gardikiotis A, Giomataris I, Golm J, Hailey CH, Hasinoff MD, Hoffmann DHH, Irastorza IG, Jacoby J, Jakobsen AC, Jakovčić K, Kaminski J, Karuza M, Kostoglou S, Krieger C, Lakić B, Laurent JM, Luzón G, Malbrunot C, Margalejo C, Maroudas M, Miceli L, Mirallas H, Navarro P, Obis L, Özbey A, Özbozduman K, Papaevangelou T, Pérez O, Pivovaroff MJ, Rosu M, Ruiz-Chóliz E, Ruz J, Schmidt S, Schumann M, Semertzidis YK, Solanki SK, Stewart L, Vafeiadis T, Vogel JK, and Zioutas K

Abstract

Hypothetical axions provide a compelling explanation for dark matter and could be emitted from the hot solar interior. The CERN Axion Solar Telescope has been searching for solar axions via their back conversion to x-ray photons in a 9-T 10-m long magnet directed toward the Sun. We report on an extended run with the International Axion Observatory pathfinder detector, doubling the previous exposure time. The detector was operated with a xenon-based gas mixture for part of the new run, providing technical insights for future configurations. No counts were detected in the 95% signal-encircling region during the new run, while 0.75 were expected. The new data improve the axion-photon coupling limit to 5.8×10^{-11}  GeV^{-1} at 95% CL (for m&#95;{a}≲0.02  eV), the most restrictive experimental limit to date.

Published
2024
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178. Search for Dark Matter Axions with CAST-CAPP.

Author

Adair CM, Altenmüller K, Anastassopoulos V, Arguedas Cuendis S, Baier J, Barth K, Belov A, Bozicevic D, Bräuninger H, Cantatore G, Caspers F, Castel JF, Çetin SA, Chung W, Choi H, Choi J, Dafni T, Davenport M, Dermenev A, Desch K, Döbrich B, Fischer H, Funk W, Galan J, Gardikiotis A, Gninenko S, Golm J, Hasinoff MD, Hoffmann DHH, Díez Ibáñez D, Irastorza IG, Jakovčić K, Kaminski J, Karuza M, Krieger C, Kutlu Ç, Lakić B, Laurent JM, Lee J, Lee S, Luzón G, Malbrunot C, Margalejo C, Maroudas M, Miceli L, Mirallas H, Obis L, Özbey A, Özbozduman K, Pivovaroff MJ, Rosu M, Ruz J, Ruiz-Chóliz E, Schmidt S, Schumann M, Semertzidis YK, Solanki SK, Stewart L, Tsagris I, Vafeiadis T, Vogel JK, Vretenar M, Youn S, and Zioutas K

Abstract

The CAST-CAPP axion haloscope, operating at CERN inside the CAST dipole magnet, has searched for axions in the 19.74 μeV to 22.47 μeV mass range. The detection concept follows the Sikivie haloscope principle, where Dark Matter axions convert into photons within a resonator immersed in a magnetic field. The CAST-CAPP resonator is an array of four individual rectangular cavities inserted in a strong dipole magnet, phase-matched to maximize the detection sensitivity. Here we report on the data acquired for 4124 h from 2019 to 2021. Each cavity is equipped with a fast frequency tuning mechanism of 10 MHz/ min between 4.774 GHz and 5.434 GHz. In the present work, we exclude axion-photon couplings for virialized galactic axions down to g aγγ  = 8 × 10 -14 GeV -1 at the 90% confidence level. The here implemented phase-matching technique also allows for future large-scale upgrades., (© 2022. The Author(s).)

Published
2022
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179. TREX-DM: a low-background Micromegas-based TPC for low-mass WIMP detection.

Author

Iguaz FJ, Garza JG, Aznar F, Castel JF, Cebrián S, Dafni T, García JA, Irastorza IG, Lagraba A, Luzón G, and Peiró A

Abstract

If Dark Matter is made of Weakly Interacting Massive Particles (WIMPs) with masses below [Formula: see text] GeV, the corresponding nuclear recoils in mainstream WIMP experiments are of energies too close, or below, the experimental threshold. Gas Time Projection Chambers (TPCs) can be operated with a variety of target elements, offer good tracking capabilities and, on account of the amplification in gas, very low thresholds are achievable. Recent advances in electronics and in novel radiopure TPC readouts, especially micro-mesh gas structure (Micromegas), are improving the scalability and low-background prospects of gaseous TPCs. Here we present TREX-DM, a prototype to test the concept of a Micromegas-based TPC to search for low-mass WIMPs. The detector is designed to host an active mass of [Formula: see text] kg of Ar at 10 bar, or alternatively [Formula: see text] kg of Ne at 10 bar, with an energy threshold below 0.4 keVee, and is fully built with radiopure materials. We will describe the detector in detail, the results from the commissioning phase on surface, as well as a preliminary background model. The anticipated sensitivity of this technique may go beyond current experimental limits for WIMPs of masses of 2-8 GeV.

Published
2016
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180. Search for solar axions by the CERN axion solar telescope with 3He buffer gas: closing the hot dark matter gap.

Author

Arik M, Aune S, Barth K, Belov A, Borghi S, Bräuninger H, Cantatore G, Carmona JM, Cetin SA, Collar JI, Da Riva E, Dafni T, Davenport M, Eleftheriadis C, Elias N, Fanourakis G, Ferrer-Ribas E, Friedrich P, Galán J, García JA, Gardikiotis A, Garza JG, Gazis EN, Geralis T, Georgiopoulou E, Giomataris I, Gninenko S, Gómez H, Gómez Marzoa M, Gruber E, Guthörl T, Hartmann R, Hauf S, Haug F, Hasinoff MD, Hoffmann DH, Iguaz FJ, Irastorza IG, Jacoby J, Jakovčić K, Karuza M, Königsmann K, Kotthaus R, Krčmar M, Kuster M, Lakić B, Lang PM, Laurent JM, Liolios A, Ljubičić A, Luzón G, Neff S, Niinikoski T, Nordt A, Papaevangelou T, Pivovaroff MJ, Raffelt G, Riege H, Rodríguez A, Rosu M, Ruz J, Savvidis I, Shilon I, Silva PS, Solanki SK, Stewart L, Tomás A, Tsagri M, van Bibber K, Vafeiadis T, Villar J, Vogel JK, Yildiz SC, and Zioutas K

Abstract

The CERN Axion Solar Telescope has finished its search for solar axions with (3)He buffer gas, covering the search range 0.64 eV ≲ ma ≲ 1.17 eV. This closes the gap to the cosmological hot dark matter limit and actually overlaps with it. From the absence of excess x rays when the magnet was pointing to the Sun we set a typical upper limit on the axion-photon coupling of gaγ ≲ 3.3 × 10(-10)  GeV(-1) at 95% C.L., with the exact value depending on the pressure setting. Future direct solar axion searches will focus on increasing the sensitivity to smaller values of gaγ, for example by the currently discussed next generation helioscope International AXion Observatory.

Published
2014
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181. Search for sub-eV mass solar axions by the CERN Axion Solar Telescope with 3He buffer gas.

Author

Arik M, Aune S, Barth K, Belov A, Borghi S, Bräuninger H, Cantatore G, Carmona JM, Cetin SA, Collar JI, Dafni T, Davenport M, Eleftheriadis C, Elias N, Ezer C, Fanourakis G, Ferrer-Ribas E, Friedrich P, Galán J, García JA, Gardikiotis A, Gazis EN, Geralis T, Giomataris I, Gninenko S, Gómez H, Gruber E, Guthörl T, Hartmann R, Haug F, Hasinoff MD, Hoffmann DH, Iguaz FJ, Irastorza IG, Jacoby J, Jakovčić K, Karuza M, Königsmann K, Kotthaus R, Krčmar M, Kuster M, Lakić B, Laurent JM, Liolios A, Ljubičić A, Lozza V, Lutz G, Luzón G, Morales J, Niinikoski T, Nordt A, Papaevangelou T, Pivovaroff MJ, Raffelt G, Rashba T, Riege H, Rodríguez A, Rosu M, Ruz J, Savvidis I, Silva PS, Solanki SK, Stewart L, Tomás A, Tsagri M, van Bibber K, Vafeiadis T, Villar JA, Vogel JK, Yildiz SC, and Zioutas K

Abstract

The CERN Axion Solar Telescope (CAST) has extended its search for solar axions by using (3)He as a buffer gas. At T=1.8 K this allows for larger pressure settings and hence sensitivity to higher axion masses than our previous measurements with (4)He. With about 1 h of data taking at each of 252 different pressure settings we have scanned the axion mass range 0.39 eV≲m(a)≲0.64 eV. From the absence of excess x rays when the magnet was pointing to the Sun we set a typical upper limit on the axion-photon coupling of g(aγ)≲2.3×10(-10) GeV(-1) at 95% C.L., the exact value depending on the pressure setting. Kim-Shifman-Vainshtein-Zakharov axions are excluded at the upper end of our mass range, the first time ever for any solar axion search. In the future we will extend our search to m(a)≲1.15 eV, comfortably overlapping with cosmological hot dark matter bounds.

Published
2011
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182. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

Author

Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Ramírez L, Viayna E, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Bidon-Chanal A, Huertas O, Dafni T, and Luque FJ

Subjects
Alzheimer Disease epidemiology, Amino Acid Motifs, Amyloid Precursor Protein Secretases antagonists & inhibitors, Amyloid beta-Peptides chemistry, Amyloid beta-Peptides metabolism, Aspartic Acid Endopeptidases antagonists & inhibitors, Cholinesterase Inhibitors chemistry, Cholinesterase Inhibitors pharmacology, Cholinesterase Inhibitors therapeutic use, Donepezil, Drug Discovery, Humans, Indans chemistry, Indans pharmacology, Indans therapeutic use, Models, Molecular, Piperidines chemistry, Piperidines pharmacology, Piperidines therapeutic use, Protein Multimerization drug effects, Protein Structure, Quaternary, Quinolines chemistry, Quinolines pharmacology, Quinolines therapeutic use, Tacrine therapeutic use, Acetylcholinesterase chemistry, Acetylcholinesterase metabolism, Alzheimer Disease drug therapy, Catalytic Domain, Tacrine chemistry, Tacrine pharmacology
Abstract

Two novel families of dual binding site acetylcholinesterase (AChE) inhibitors have been developed, consisting of a tacrine or 6-chlorotacrine unit as the active site interacting moiety, either the 5,6-dimethoxy-2-[(4-piperidinyl)methyl]-1-indanone fragment of donepezil (or the indane derivative thereof) or a 5-phenylpyrano[3,2-c]quinoline system, reminiscent to the tryciclic core of propidium, as the peripheral site interacting unit, and a linker of suitable length as to allow the simultaneous binding at both sites. These hybrid compounds are all potent and selective inhibitors of human AChE, and more interestingly, are able to interfere in vitro both formation and aggregation of the beta-amyloid peptide, the latter effects endowing these compounds with the potential to modify Alzheimer's disease progression., (Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.)

Published
2010
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183. Observation of a J(PC)=1-+ exotic resonance in diffractive dissociation of 190   GeV/c π- into π- π- π+.

Author

Alekseev MG, Alexakhin VY, Alexandrov Y, Alexeev GD, Amoroso A, Austregesilo A, Badełek B, Balestra F, Ball J, Barth J, Baum G, Bedfer Y, Bernhard J, Bertini R, Bettinelli M, Birsa R, Bisplinghoff J, Bordalo P, Bradamante F, Bravar A, Bressan A, Brona G, Burtin E, Bussa MP, Chapiro A, Chiosso M, Chung SU, Cicuttin A, Colantoni M, Crespo ML, Dalla Torre S, Dafni T, Das S, Dasgupta SS, Denisov OY, Dhara L, Diaz V, Dinkelbach AM, Donskov SV, Doshita N, Duic V, Dünnweber W, Efremov A, El Alaoui A, Eversheim PD, Eyrich W, Faessler M, Ferrero A, Finger M, Finger M Jr, Fischer H, Franco C, Friedrich JM, Garfagnini R, Gautheron F, Gavrichtchouk OP, Gazda R, Gerassimov S, Geyer R, Giorgi M, Gobbo B, Goertz S, Grabmüller S, Grajek OA, Grasso A, Grube B, Gushterski R, Guskov A, Haas F, von Harrach D, Hasegawa T, Heckmann J, Heinsius FH, Hermann R, Herrmann F, Hess C, Hinterberger F, Horikawa N, Höppner Ch, d'Hose N, Ilgner C, Ishimoto S, Ivanov O, Ivanshin Y, Iwata T, Jahn R, Jasinski P, Jegou G, Joosten R, Kabuss E, Kang D, Ketzer B, Khaustov GV, Khokhlov YA, Kisselev Y, Klein F, Klimaszewski K, Koblitz S, Koivuniemi JH, Kolosov VN, Komissarov EV, Kondo K, Königsmann K, Konopka R, Konorov I, Konstantinov VF, Korzenev A, Kotzinian AM, Kouznetsov O, Kowalik K, Krämer M, Kral A, Kroumchtein ZV, Kuhn R, Kunne F, Kurek K, Lauser L, Le Goff JM, Lednev AA, Lehmann A, Levorato S, Lichtenstadt J, Liska T, Maggiora A, Maggiora M, Magnon A, Mallot GK, Mann A, Marchand C, Marroncle J, Martin A, Marzec J, Massmann F, Matsuda T, Maximov AN, Meyer W, Michigami T, Mikhailov YV, Moinester MA, Mutter A, Nagaytsev A, Nagel T, Nassalski J, Negrini T, Nerling F, Neubert S, Neyret D, Nikolaenko VI, Olshevsky AG, Ostrick M, Padee A, Panknin R, Panzieri D, Parsamyan B, Paul S, Pawlukiewicz-Kaminska B, Perevalova E, Pesaro G, Peshekhonov DV, Piragino G, Platchkov S, Pochodzalla J, Polak J, Polyakov VA, Pontecorvo G, Pretz J, Quintans C, Rajotte JF, Ramos S, Rapatsky V, Reicherz G, Reggiani D, Richter A, Robinet F, Rocco E, Rondio E, Ryabchikov DI, Samoylenko VD, Sandacz A, Santos H, Sapozhnikov MG, Sarkar S, Savin IA, Sbrizzai G, Schiavon P, Schill C, Schlüter T, Schmitt L, Schopferer S, Schröder W, Shevchenko OY, Siebert HW, Silva L, Sinha L, Sissakian AN, Slunecka M, Smirnov GI, Sosio S, Sozzi F, Srnka A, Stolarski M, Sulc M, Sulej R, Takekawa S, Tessaro S, Tessarotto F, Teufel A, Tkatchev LG, Uhl S, Uman I, Venugopal G, Virius M, Vlassov NV, Vossen A, Weitzel Q, Windmolders R, Wiślicki W, Wollny H, Zaremba K, Zavertyaev M, Zemlyanichkina E, Ziembicki M, Zhao J, Zhuravlev N, and Zvyagin A

Abstract

The COMPASS experiment at the CERN SPS has studied the diffractive dissociation of negative pions into the π- π- π+ final state using a 190  GeV/c pion beam hitting a lead target. A partial wave analysis has been performed on a sample of 420,000 events taken at values of the squared 4-momentum transfer t' between 0.1 and 1  GeV2/c2. The well-known resonances a1(1260), a2(1320), and π2(1670) are clearly observed. In addition, the data show a significant natural-parity exchange production of a resonance with spin-exotic quantum numbers J(PC)=1-+ at 1.66  GeV/c2 decaying to ρπ. The resonant nature of this wave is evident from the mass-dependent phase differences to the J(PC)=2-+ and 1++ waves. From a mass-dependent fit a resonance mass of (1660±10(-64)(+0))  MeV/c2 and a width of (269±21(-64)(+42))  MeV/c2 are deduced, with an intensity of (1.7±0.2)% of the total intensity.

Published
2010
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184. Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

Author

Camps P, Formosa X, Galdeano C, Muñoz-Torrero D, Ramírez L, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodríguez-Franco MI, Huertas O, Dafni T, and Luque FJ

Subjects
Amyloid Precursor Protein Secretases antagonists & inhibitors, Animals, Binding Sites, Blood-Brain Barrier drug effects, Blood-Brain Barrier metabolism, Butyrylcholinesterase metabolism, Cattle, Cholinesterase Inhibitors chemistry, Cholinesterase Inhibitors metabolism, Cholinesterase Inhibitors therapeutic use, Drug Design, Humans, Isomerism, Membranes, Artificial, Mice, Models, Molecular, Molecular Conformation, Permeability, Protein Binding drug effects, Tacrine chemistry, Tacrine metabolism, Tacrine pharmacology, Tacrine therapeutic use, Acetylcholinesterase metabolism, Alzheimer Disease drug therapy, Amyloid beta-Peptides metabolism, Cholinesterase Inhibitors pharmacology, Tacrine analogs & derivatives
Abstract

Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and beta-secretase (BACE-1) and to cross blood-brain barrier. The new hybrids consist of a unit of 6-chlorotacrine and a multicomponent reaction-derived pyrano[3,2-c]quinoline scaffold as the active-site and peripheral-site interacting moieties, respectively, connected through an oligomethylene linker containing an amido group at variable position. Indeed, molecular modeling and kinetic studies have confirmed the dual site binding of these compounds. The new hybrids, and particularly 27, retain the potent and selective human AChE inhibitory activity of the parent 6-chlorotacrine while exhibiting a significant in vitro inhibitory activity toward the AChE-induced and self-induced Abeta aggregation and toward BACE-1, as well as ability to enter the central nervous system, which makes them promising anti-Alzheimer lead compounds.

Published
2009
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185. First results from the CERN axion solar telescope.

Author

Zioutas K, Andriamonje S, Arsov V, Aune S, Autiero D, Avignone FT, Barth K, Belov A, Beltrán B, Bräuninger H, Carmona JM, Cebrián S, Chesi E, Collar JI, Creswick R, Dafni T, Davenport M, Di Lella L, Eleftheriadis C, Englhauser J, Fanourakis G, Farach H, Ferrer E, Fischer H, Franz J, Friedrich P, Geralis T, Giomataris I, Gninenko S, Goloubev N, Hasinoff MD, Heinsius FH, Hoffmann DH, Irastorza IG, Jacoby J, Kang D, Königsmann K, Kotthaus R, Krcmar M, Kousouris K, Kuster M, Lakić B, Lasseur C, Liolios A, Ljubicić A, Lutz G, Luzón G, Miller DW, Morales A, Morales J, Mutterer M, Nikolaidis A, Ortiz A, Papaevangelou T, Placci A, Raffelt G, Ruz J, Riege H, Sarsa ML, Savvidis I, Serber W, Serpico P, Semertzidis Y, Stewart L, Vieira JD, Villar J, Walckiers L, and Zachariadou K

Abstract

Hypothetical axionlike particles with a two-photon interaction would be produced in the sun by the Primakoff process. In a laboratory magnetic field ("axion helioscope"), they would be transformed into x-rays with energies of a few keV. Using a decommissioned Large Hadron Collider test magnet, the CERN Axion Solar Telescope ran for about 6 months during 2003. The first results from the analysis of these data are presented here. No signal above background was observed, implying an upper limit to the axion-photon coupling g(agamma)<1.16x10(-10) GeV-1 at 95% C.L. for m(a) less, similar 0.02 eV. This limit, assumption-free, is comparable to the limit from stellar energy-loss arguments and considerably more restrictive than any previous experiment over a broad range of axion masses.

Published
2005
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