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153. Marked reduction of ANAE reactivity of T cells in the lymphoid tissues of monkeys treated with multiple high doses of human beta interferon

Author

Ohtaki, S., Tatsumi, M., Kohase, M., and Yamazaki, S.

Subjects
Macaca fascicularis, Naphthol AS D Esterase, Time Factors, T-Lymphocytes, Interferon Type I, Animals, Female, Lymph Nodes, Thymus Gland, skin and connective tissue diseases, Carboxylic Ester Hydrolases, Spleen, Research Article
Abstract

We report a histological study of the organs and tissues of cynomolgus monkeys which had received multiple high doses of human beta interferon (IFN). There were dense aggregations of small lymphocytes without the acid alpha-naphthyl acetate esterase (ANAE) reactivity in the thymus-dependent areas (TDA) of lymphoid tissues, indicating that the T mu cells of IFN-treated monkeys had lost this characteristic enzyme. This change of T mu cells in the tissues was not accompanied by a change in circulating T mu cells.

Published
1983

154. [Mechanisms of dental plaque and calculus formation due to fibronectin. 2. Demonstration of fibronectin in the enamel pellicle]

Author

Tatsumi M, Takagi N, Yu Sf, Masaru Sato, Namikawa I, Fujii T, Hiroshi Takeuchi, and Hori Y

Subjects
Pathology, medicine.medical_specialty, biology, business.industry, Chemistry, Calculus (dental), Dental Plaque, Dentistry, medicine.disease, Dental plaque, Enamel Pellicle, Fibronectins, Fibronectin, Dental Deposits, biology.protein, medicine, Humans, Dental Calculus, Dental Pellicle, business, Dental Enamel, Saliva
Abstract

fibronectin は in vivo および in vitro において, 種々の物質と強い粘着性を示す。このような物質が唾液中に存在することから, 獲得被膜の主要材料となることが推測し得る。この点を今少し明確にするために, ヒト抜去歯の研磨標本のエナメル質表層に付着した獲得被膜中に fibronectin が存在するか否かを免疫組織学的に検討した。この結果, 獲得被膜中の fibronectin は, 被験歯30例中29例の高頻度に検出され, カルボール・フクシン後染色との対比観察によって, 本染色で染め出された被膜中はもとより, 無染の部位にまで付着していることが判明した。

Published
1984

167. A Community Health Council and Its Significance

Author

Nakamura, T., primary, Katsunuma, H., additional, Wako, H., additional, Uematsu, M., additional, Tatsumi, M., additional, Oikawa, S., additional, Kato, K., additional, Moriguchi, T., additional, Takahashi, M., additional, Sasaki, T., additional, and Masuda, S., additional

Published
1967
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168. STUDIES ON POLIOMYELITIS IN JAPAN

Author

KONO, R., primary, ASHIHARA, Y., additional, KAWAKAMI, K., additional, MATSUMIYA, T., additional, HIRAYAMA, M., additional, KUBOTA, H., additional, and TATSUMI, M., additional

Published
1958
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180. Dual involvement of growth arrest-specific gene 6 in the early phase of human IgA nephropathy.

Author

Kojiro Nagai, Masashi Miyoshi, Takei Kake, Naoshi Fukushima, Motokazu Matsuura, Eriko Shibata, Satoshi Yamada, Kazuhiro Yoshikawa, Hiro-Omi Kanayama, Tomoya Fukawa, Kunihisa Yamaguchi, Hirofumi Izaki, Akira Mima, Naoko Abe, Toshikazu Araoka, Taichi Murakami, Fumi Kishi, Seiji Kishi, Tatsuya Tominaga, Tatsumi Moriya, Hideharu Abe, and Toshio Doi

Subjects
Medicine, Science
Abstract

BACKGROUND: Gas6 is a growth factor that causes proliferation of mesangial cells in the development of glomerulonephritis. Gas6 can bind to three kinds of receptors; Axl, Dtk, and Mer. However, their expression and functions are not entirely clear in the different glomerular cell types. Meanwhile, representative cell cycle regulatory protein p27 has been reported to be expressed in podocytes in normal glomeruli with decreased expression in proliferating glomeruli, which inversely correlated with mesangial proliferation in human IgA nephropathy (IgAN). METHODS: The aim of this study is to clarify Gas6 involvement in the progression of IgAN. Expression of Gas6/Axl/Dtk was examined in 31 biopsy proven IgAN cases. We compared the expression levels with histological severity or clinical data. Moreover, we investigated the expression of Gas6 and its receptors in cultured podocytes. RESULTS: In 28 of 31 cases, Gas6 was upregulated mainly in podocytes. In the other 3 cases, Gas6 expression was induced in endothelial and mesangial cells, which was similar to animal nephritis models. Among 28 podocyte type cases, the expression level of Gas6 correlated with the mesangial hypercellularity score of IgAN Oxford classification and urine protein excretion. It also inversely correlated with p27 expression in glomeruli. As for the receptors, Axl was mainly expressed in endothelial and mesangial cells, while Dtk was expressed in podocytes. In vitro, Dtk was expressed in cultured murine podocytes, and the expression of p27 was decreased by Gas6 stimulation. CONCLUSIONS: Gas6 was uniquely upregulated in either endothelial/mesangial cells or podocytes in IgAN. The expression pattern can be used as a marker to classify IgAN. Gas6 has a possibility to be involved in not only mesangial proliferation via Axl, but also podocyte injury via Dtk in IgAN.

Published
2013
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181. Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

Author

Sasayama Daimei, Hori Hiroaki, Teraishi Toshiya, Hattori Kotaro, Ota Miho, Iijima Yoshimi, Tatsumi Masahiko, Higuchi Teruhiko, Amano Naoji, and Kunugi Hiroshi

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Several lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1β) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms. Methods A total of 533 patients with schizophrenia (302 males: mean age ± standard deviation 43.4 ± 13.0 years; 233 females; mean age 44.8 ± 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 ± 17.3 years; 748 females; 46.3 ± 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1β gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia. Results Significant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). Conclusions The present study shows the first evidence that the IL-1β gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1β gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1β in the etiology of schizophrenia.

Published
2011
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185. Psychometric Properties and Correlates of Precarious Manhood Beliefs in 62 Nations

Author

John Jamir Benzon R. Aruta, Dashamir Bërxulli, Tomasz Besta, Soline Ammirati, Ana Makashvili, Sandesh Dhakal, Mandy Boehnke, Emma C. O’Connor, Jennifer K. Bosson, Hedy Greijdanus, Janine Bosak, Serdar Karabati, Monika Kovacs, Emma A. Renström, Martina Hřebíčková, Neharika Vohra, Valeska Zanello, Ani Grigoryan, Vincent Yzerbyt, Marco Salvati, Eric S. Mankowski, Jorge Palacio, Joaquín Ungaretti, Collins Badu Agyemang, Vassilis Pavlopoulos, Sylvie Graf, Vadym Vasiutynskyi, Masoumeh Seydi, Dominique Muller, Junyi Li, Alin Gavreliuc, Adil Samekin, Antonella Ludmila Zapata-Calvente, Carla Sofia Esteves, Soledad de Lemus, Amarina Ariyanto, Nikolay Dvorianchikov, Angela T. Maitner, A. Timur Sevincer, Maja Becker, Justine Dandy, Tiphaine Rousseaux, Simon Schindler, Tiziana Mancini, Sachiko Ohno, Serena Daalmans, Desirée Kozlowski, Francesca Guizzo, Rosita Sobhie, Nhan Thi Lac An, Claudia Manzi, Sami Abuhamdeh, Chongzeng Bi, Mary Anne Lauri, Juliana Barreiros Porto, Erico Rentería Pérez, Sonoko Egami, Gabriella Kengyel, Hannah Hämer, Vladimir Mihić, Rawan Ghazzawi, Jasna Milošević Đorđević, Katie E. Sullivan, Mariko Tatsumi, Sadia Malik, Quang Thi Mong Chi, Sarah E. Martiny, Sara Sherbaji, Michael Bender, Narine Khachatryan, Lucy R. Tavitian-Elmadjian, Katharina Block, Miriam-Linnea Hale, Deborah L. Best, Andrew B. Moynihan, Nihan Albayrak-Aydemir, Mika Hirai, Sulaiman Olanrewaju Adebayo, Abiodun Musbau Lawal, Qingwei Chen, Marta Walentynowicz, Annalisa Casini, Dorthe Høj Jensen, Cláudio Vaz Torres, Aistė Bakaitytė, Edgardo Etchezahar, Natasza Kosakowska-Berezecka, Mujeeba Ashraf, Magdalena Zawisza, Paweł Jurek, Anna Lindqvist, Silvia Mari, Joanna Grzymała-Moszczyńska, Shera Malayeri, Peilian Chi, Toni Schmader, Danielle P. Ochoa, Michał Olech, Pablo Perez de Leon, Teri A. Kirby, Ana Raquel Rosas Torres, Lucille De Souza, Kimberly A. Noels, Erita Narhetali, Saba Safdar, Chiara Bertolli, Vera Cubela Adoric, Emma Sarter, Mary Kinahan, Angelica Puzio, Beril Türkoğlu, Laura Froehlich, Clara Kulich, Jolanda van der Noll, Dijana Sulejmanović, Christin-Melanie Vauclair, Jana Lindner, Timothy Jacob Valshtein, Mario Sainz, Randall E. Osborne, Colleen Ward, Tai Kurosawa, Snigdha Patnaik, Rita Žukauskienė, Paul B. Hutchings, Suparna Jain Thakur, Javier Labarthe, Inga Jasinskaja-Lahti, Anna Wlodarczyk, Boglárka Nyúl, Kaltrina Kelmendi, Claude-Hélène Mayer, Colette van Laar, Michelle K. Ryan, Beatriz Torre, Debra Shepherd, Yaping Yang, Félix Neto, Keltouma Guerch, Maria Giuseppina Pacilli, Gulnaz Anjum, Neto Felix, Vladislav Krivoshchekov, Marie Gustafsson Sendén, Efraín García-Sánchez, Joel Anderson, Lam Hoang Duc, Satu Venäläinen, Elena Makarova, Cláudia Simão, Joseph A. Vandello, Joanna Pyrkosz-Pacyna, Dana Gavreliuc, Ioana M Latu, Silvia Moscatelli, Gülçin Akbaş, Magdalena Żadkowska, Renata Bongiorno, Eva Moreno-Bella, Vera Hoorens, Ángel Gómez, Ivana Piterová, Cognition, Langues, Langage, Ergonomie (CLLE-LTC), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Bosson, J, Jurek, P, Vandello, J, Kosakowska-Berezecka, N, Olech, M, Besta, T, Bender, M, Hoorens, V, Becker, M, Timur Sevincer, A, Best, D, Safdar, S, Wlodarczyk, A, Zawisza, M, Zadkowska, M, Abuhamdeh, S, Badu Agyemang, C, Akbas, G, Albayrak-Aydemir, N, Ammirati, S, Anderson, J, Anjum, G, Ariyanto, A, Jamir Benzon, R, Ashraf, M, Bakaityte, A, Bertolli, C, Berxulli, D, Bi, C, Block, K, Boehnke, M, Bongiorno, R, Bosak, J, Casini, A, Chen, Q, Chi, P, Cubela Adoric, V, Daalmans, S, Dandy, J, Lemus, S, Dhakal, S, Dvorianchikov, N, Egami, S, Etchezahar, E, Sofia Esteves, C, Felix, N, Froehlich, L, Garcia-Sanchez, E, Gavreliuc, A, Gavreliuc, D, Gomez, A, Guizzo, F, Graf, S, Greijdanus, H, Grigoryan, A, Grzymala-Moszczynska, J, Guerch, K, Gustafsson Senden, M, Hale, M, Hamer, H, Hirai, M, Hoang Duc, L, Hrebickova, M, Hutchings, P, Hoj Jensen, D, Jasinskaja-Lahti, I, Karabati, S, Kelmendi, K, Kengyel, G, Khachatryan, N, Ghazzawi, R, Kinahan, M, Kirby, T, Kovacs, M, Kozlowski, D, Krivoshchekov, V, Kulich, C, Kurosawa, T, Thi Lac An, N, Labarthe, J, Latu, I, Anne Lauri, M, Mankowski, E, Musbau Lawal, A, Li, J, Lindner, J, Lindqvist, A, Maitner, A, Makarova, E, Makashvili, A, Malayeri, S, Malik, S, Mancini, T, Manzi, C, Mari, S, Martiny, S, Mayer, C, Mihic, V, Milosevic Dordevic, J, Moreno-Bella, E, Moscatelli, S, Bryan Moynihan, A, Muller, D, Narhetali, E, Neto, F, Noels, K, Nyul, B, O'Connor, E, Ochoa, D, Ohno, S, Olanrewaju Adebayo, S, Osborne, R, Giuseppina Pacilli, M, Palacio, J, Patnaik, S, Pavlopoulos, V, Perez de Leon, P, Piterova, I, Barreiros Porto, J, Puzio, A, Pyrkosz-Pacyna, J, Renteria Perez, E, Renstrom, E, Rousseaux, T, Ryan, M, Sainz, M, Salvati, M, Samekin, A, Schindler, S, Seydi, M, Shepherd, D, Sherbaji, S, Schmader, T, Simao, C, Sobhie, R, Souza, L, Sarter, E, Sulejmanovic, D, Sullivan, K, Tatsumi, M, Tavitian-Elmadjian, L, Jain Thakur, S, Thi Mong Chi, Q, Torre, B, Torres, A, Torres, C, Turkoglu, B, Ungaretti, J, Valshtein, T, Van Laar, C, van der Noll, J, Vasiutynskyi, V, Vauclair, C, Venalainen, S, Vohra, N, Walentynowicz, M, Ward, C, Yang, Y, Yzerbyt, V, Zanello, V, Ludmila Zapata-Calvente, A, Zukauskiene, R, UCL - SSH/IPSY - Psychological Sciences Research Institute, Social Psychology, Research programme OB, Faculdade de Psicologia e de Ciências da Educação, Bosson J.K., Jurek P., Vandello J.A., Kosakowska-Berezecka N., Olech M., Besta T., Bender M., Hoorens V., Becker M., Timur Sevincer A., Best D.L., Safdar S., Wlodarczyk A., Zawisza M., Zadkowska M., Abuhamdeh S., Badu Agyemang C., Akbas G., Albayrak-Aydemir N., Ammirati S., Anderson J., Anjum G., Ariyanto A., Jamir Benzon R. Aruta J., Ashraf M., Bakaityte A., Bertolli C., Berxulli D., Bi C., Block K., Boehnke M., Bongiorno R., Bosak J., Casini A., Chen Q., Chi P., Cubela Adoric V., Daalmans S., Dandy J., Lemus S.D., Dhakal S., Dvorianchikov N., Egami S., Etchezahar E., Sofia Esteves C., Felix N., Froehlich L., Garcia-Sanchez E., Gavreliuc A., Gavreliuc D., Gomez A., Guizzo F., Graf S., Greijdanus H., Grigoryan A., Grzymala-Moszczynska J., Guerch K., Gustafsson Senden M., Hale M.-L., Hamer H., Hirai M., Hoang Duc L., Hrebickova M., Hutchings P.B., Hoj Jensen D., Jasinskaja-Lahti I., Karabati S., Kelmendi K., Kengyel G., Khachatryan N., Ghazzawi R., Kinahan M., Kirby T.A., Kovacs M., Kozlowski D., Krivoshchekov V., Kulich C., Kurosawa T., Thi Lac An N., Labarthe J., Latu I., Anne Lauri M., Mankowski E., Musbau Lawal A., Li J., Lindner J., Lindqvist A., Maitner A.T., Makarova E., Makashvili A., Malayeri S., Malik S., Mancini T., Manzi C., Mari S., Martiny S.E., Mayer C.-H., Mihic V., Milosevic Dordevic J., Moreno-Bella E., Moscatelli S., Bryan Moynihan A., Muller D., Narhetali E., Neto F., Noels K.A., Nyul B., O'Connor E.C., Ochoa D.P., Ohno S., Olanrewaju Adebayo S., Osborne R., Giuseppina Pacilli M., Palacio J., Patnaik S., Pavlopoulos V., Perez de Leon P., Piterova I., Barreiros Porto J., Puzio A., Pyrkosz-Pacyna J., Renteria Perez E., Renstrom E., Rousseaux T., Ryan M.K., Sainz M., Salvati M., Samekin A., Schindler S., Seydi M., Shepherd D., Sherbaji S., Schmader T., Simao C., Sobhie R., Souza L.D., Sarter E., Sulejmanovic D., Sullivan K.E., Tatsumi M., Tavitian-Elmadjian L., Jain Thakur S., Thi Mong Chi Q., Torre B., Torres A., Torres C.V., Turkoglu B., Ungaretti J., Valshtein T., Van Laar C., van der Noll J., Vasiutynskyi V., Vauclair C.-M., Venalainen S., Vohra N., Walentynowicz M., Ward C., Yang Y., Yzerbyt V., Zanello V., Ludmila Zapata-Calvente A., Zukauskiene R., and Veritati - Repositório Institucional da Universidade Católica Portuguesa

Subjects
Cultural Studies, Ciências Sociais::Sociologia [Domínio/Área Científica], Social Psychology, media_common.quotation_subject, 300 Social sciences, sociology & anthropology, Social Sciences, [SHS.PSY]Humanities and Social Sciences/Psychology, 050109 social psychology, Ambivalence, Ciências Sociais::Psicologia [Domínio/Área Científica], Psychology, Social, Precarious manhood beliefs, 050105 experimental psychology, ddc:150, Psychometric isomorphism, precarious manhood beliefs, ambivalent sexism, ambivalence toward men, Psychology, 0501 psychology and cognitive sciences, Meaning (existential), media_common, Isomorphism (sociology), Ciências Sociais::Antropologia [Domínio/Área Científica], precarious manhood belief, 4. Education, 05 social sciences, psychometric isomorphism, precarious manhood beliefs, ambivalent sexism, ambivalence toward men, 16. Peace & justice, Ambivalence toward men, Human development (humanity), Settore M-PSI/05 - PSICOLOGIA SOCIALE, 3. Good health, Communication and Media, Ambivalent sexism, Scale (social sciences), Anthropology, [SCCO.PSYC]Cognitive science/Psychology, Ideology, 150 Psychology, Social psychology, Social status
Abstract

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by a Grant from the National Science Centre in Poland (Grant Number: 2017/26/M/HS6/00360) awarded to Natasza Kosakowska-Berezecka. Data collection by the following researchers was supported by Grants as follows: Emma C. O'Connor (Grant RL5GM118963 from National Institute of General Medical Sciences of the National Institutes of Health; Angel Gomez (Grant RTI2018-093550-B-I00 from the Universidad Nacional de Educacion a Distancia, Spain); Sylvie Graf and Martina Hrebickova (Grant 20-01214S from the Czech Science Foundation, and Grant RVO: 68081740 from the Institute of Psychology, Czech Academy of Sciences); Teri A. Kirby (Grant ES/S00274X/1 from the Economic and Social Research Council); Soledad de Lemus (Grant PSI2016-79971-P from Spanish Ministry of Economy and Competitiveness through the excellence); Michelle K. Ryan and Renata Bongiorno (Grant ERC-2016-COG 725128 from the European Research Council awarded to Michelle K. Ryan); Marie Gustafsson Senden, Anna Lindqvist and Emma Renstrom (Grant 2017-00414 from the Swedish Research Council for Health, Working Life, and Welfare); Claudio V. Torres (Grant DPI/DIRPE n. 04/2019 from the University of Brasilia)., This study was preregistered in Open Science Framework at https://osf.io/u9xfg/., Precarious manhood beliefs portray manhood, relative to womanhood, as a social status that is hard to earn, easy to lose, and proven via public action. Whereas qualitative and ethnographic data suggest that many cultures conceptualize manhood as precarious, quantitative research has yet to demonstrate the cross-cultural consistency of precarious manhood beliefs. Here, we examined the psychometric isomorphism, or measurement invariance, of a brief precarious manhood beliefs scale (the PMB). Using data from university samples in 62 countries across 13 world regions (N=33,417), we examined: (1) the isomorphism of the PMB across individual and country levels; (2) the PMB’s distinctness from, and associations with, other cross-culturally validated gender ideologies (e.g., ambivalent sexism and ambivalence toward men; Glick & Fiske, 1996, 1999); and (3) associations of the PMB with country-level indices of gender equality (the GGGI; World Economic Forum, 2019) and human development (the HDI; United Nations Development Programme, 2019). Findings indicate that the PMB is a psychometrically valid and isomorphic index of beliefs about the male gender role that accounts for unique variance in country-level gender equality and human development., National Science Center, Poland 2017/26/M/HS6/00360, United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of General Medical Sciences (NIGMS) RL5GM118963, Universidad Nacional de Educacion a Distancia, Spain RTI2018-093550-B-I00, Grant Agency of the Czech Republic 20-01214S, Institute of Psychology, Czech Academy of Sciences RVO: 68081740, UK Research & Innovation (UKRI) Economic & Social Research Council (ESRC) ES/S00274X/1, Spanish Ministry of Economy and Competitiveness PSI2016-79971-P, European Research Council (ERC) European Commission ERC-2016-COG 725128, Swedish Research Council Swedish Research Council for Health Working Life & Welfare (Forte) 2017-00414, University of Brasilia 04/2019

Published
2021
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186. Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder.

Author

Sasayama, D, Hiraishi, A, Tatsumi, M, Kamijima, K, Ikeda, M, Umene-Nakano, W, Yoshimura, R, Nakamura, J, Iwata, N, and Kunugi, H

Subjects
*GENETIC polymorphisms, *ANTIDEPRESSANTS, *MENTAL depression, *SINGLE nucleotide polymorphisms, *JAPANESE people, *GENETIC code, *PHARMACOGENOMICS, *DISEASES
Abstract

Association between response to antidepressant treatment and genetic polymorphisms was examined in two independent Japanese samples of patients with major depressive disorder (MDD). Genome-wide approach using the Illumina Human CNV370-quad Bead Chip was utilized in the analysis of the 92 MDD patients in the first sample. In all, 11 non-intergenic single-nucleotide polymorphisms with uncorrected allelic P-value <0.0001 were selected for the subsequent association analyses in the second sample of 136 MDD patients. Difference in allele distribution between responders and nonresponders were found in the second-stage sample for rs365836 and rs201522 of the CUX1 gene (P=0.005 and 0.004, respectively). The allelic P-values for rs365836 and rs201522 in both samples combined were 0.0000023 and 0.0000040, respectively. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD. [ABSTRACT FROM AUTHOR]

Published
2013
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187. Analysis of Enhancer Activity of a Dinucleotide Repeat Polymorphism in the Neurotrophin-3 Gene and Its Association with Bipolar Disorder.

Author

Tadokoro, K., Hashimoto, R., Tatsumi, M., Kamijima, K., and Kunugi, H.

Subjects
*NEUROTROPIN, *PSYCHOSES, *SCHIZOPHRENIA, *BIPOLAR disorder, *GLIOMAS, *ETHNICITY
Abstract

Growing evidence has implicated the possible involvement of neurotrophins in the pathogenesis of functional psychoses such as schizophrenia and bipolar disorder. Previous studies reported a significant association of a dinucleotide repeat polymorphism of the neurotrophin-3 (NTF3) gene with schizophrenia. The aims of the present study were to examine whether this polymorphism is associated with bipolar disorder and whether the polymorphic region has an enhancer/silencer effect on transcriptional activity in an allele-dependent manner. In an association analysis between the polymorphism and bipolar disorder in a Japanese sample of 88 patients and 98 controls matched for age, sex, and ethnicity, the distribution of alleles did not differ significantly between the two groups. pGL3-promoter luciferase reporter vectors containing the polymorphic region increased luciferase activity relative to empty pGL3-promoter vector in HeLa, IMR-32 (neuroblastoma) and Hs683 (glioma) cell lines; however, no significant difference was detected between alleles for either cell line. Our results suggest that the examined polymorphism has no major role in giving susceptibility to bipolar disorder. Although the polymorphic region may have an enhancer-like effect on transcriptional activity, we obtained no evidence for allele-dependent differential effects. Copyright © 2004 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2004
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188. Metabolic tumor volume of metastatic lymph nodes and survival after total laryngectomy in laryngeal and hypopharyngeal cancer.

Author

Fujii, T., Miyabe, J., Yoshii, T., Suzuki, M., Otozai, S., Komukai, S., Kishikawa, T., Takemoto, N., Fukusumi, T., Tatsumi, M., Hatazawa, J., and Inohara, H.

Subjects
*HYPOPHARYNGEAL cancer, *LARYNGEAL cancer, *LYMPH nodes, *LARYNGECTOMY, *THERAPEUTICS, *AKAIKE information criterion, *ANTHROPOMETRY, *COMPARATIVE studies, *RESEARCH methodology, *MEDICAL cooperation, *METASTASIS, *NECK surgery, *REGRESSION analysis, *RESEARCH, *SURVIVAL analysis (Biometry), *TUMOR classification, *EVALUATION research, *TREATMENT effectiveness, *RETROSPECTIVE studies, LARYNGEAL tumors
Abstract

Objectives: The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy.Materials and Methods: We retrospectively analyzed 88 patients receiving total laryngectomy and neck dissection, using Cox regression models.Results and Conclusion: Variables related to metastatic lymph node were associated with overall survival, whereas those related to primary tumor were not. In multivariable models, MTV of metastatic lymph nodes (N-MTV) as a continuous variable (Akaike's information criterion (AIC), 277.5) was equivalent to pathological nodal status (AIC, 278.2; P = 0.40), and superior to pathological nodal classification as an ordinal variable (AIC, 281.4; P < 0.05) in ability of predicting death. The risk of death was increased by 1.2-fold (95% confidence interval (CI), 1.0-1.4; P = 0.03) every 10-ml increment of N-MTV, while patients with pN+ disease were at a higher risk of death by 2.9-fold (95% CI, 1.0-12.2; P < 0.05) compared with patients with pN0 disease. Using recursive partitioning analysis (RPA), we classified the patients as having a low, intermediate, or high risk of death on the basis of N-MTV and extranodal extension (ENE). This RPA classification system exhibited greater concordance with overall survival than the classification considering pathological nodal status and ENE (AIC, 275.8 versus 281.4; P = 0.02). In the setting of upfront total laryngectomy, N-MTV is a critical predictor of mortality. A staging system in which N-MTV is incorporated may better inform adjuvant treatment decisions. [ABSTRACT FROM AUTHOR]

Published
2019
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189. Distribution of norovirus genotypes and subtypes in river water by ultra-deep sequencing-based analysis.

Author

Boonchan, M., Motomura, K., Inoue, K., Ode, H., Chu, P.Y., Lin, M., Iwatani, Y., Ruchusatsawat, K., Guntapong, R., Tacharoenmuang, R., Chantaroj, S., Tatsumi, M., Takeda, N., and Sangkitporn, S.

Subjects
*NOROVIRUSES, *GENOTYPES, *GENOMES, *RIVERS, *VIRUSES
Abstract

To determine the distribution of Norovirus (NoV) genotypes in natural river water in Thailand, we conducted a genome analysis using a next-generation sequencer. Twenty-five river water samples were collected at five different sites of the Khlong Klon River in the suburbs of Bangkok between August 2013 and December 2014. The partial genome of NoV was detected in 15 of the 25 samples (60·0%). Seven of these 15 samples (46·7%) contained multiple NoV GII genotypes: GII.4, GII.6, and GII.17. Our data showed that GII.17 had already emerged in August 2013 as a minor population, and it became a major genotype in December 2014. Our findings indicate that the virus was likely to have been circulating in the community before it appeared in the river water. Significance and Impact of the Study Our study was to investigate the frequencies of multiple genogroups and genotypes of norovirus in the river water near Bangkok, Thailand, by ultra-deep sequencing-based analysis. This study revealed that the epidemic strain was likely to have been circulating in the community before it appeared in the river water. Monitoring of the Norovirus (NoV) genomes in the natural environment may contribute to an understanding of the emergence of new epidemic NoV strains in human populations. [ABSTRACT FROM AUTHOR]

Published
2017
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193. Gendered self-views across 62 countries : A test of competing models

Author

Natasza Kosakowska-Berezecka, Jennifer K. Bosson, Paweł Jurek, Tomasz Besta, Michał Olech, Joseph A. Vandello, Michael Bender, Justine Dandy, Vera Hoorens, Inga Jasinskaja-Lahti, Eric Mankowski, Satu Venäläinen, Sami Abuhamdeh, Collins Badu Agyemang, Gülçin Akbaş, Nihan Albayrak-Aydemir, Soline Ammirati, Joel Anderson, Gulnaz Anjum, Amarina Ariyanto, John Jamir Benzon R. Aruta, Mujeeba Ashraf, Aistė Bakaitytė, Maja Becker, Chiara Bertolli, Dashamir Bërxulli, Deborah L. Best, Chongzeng Bi, Katharina Block, Mandy Boehnke, Renata Bongiorno, Janine Bosak, Annalisa Casini, Qingwei Chen, Peilian Chi, Vera Cubela Adoric, Serena Daalmans, Soledad de Lemus, Sandesh Dhakal, Nikolay Dvorianchikov, Sonoko Egami, Edgardo Etchezahar, Carla Sofia Esteves, Laura Froehlich, Efrain Garcia-Sanchez, Alin Gavreliuc, Dana Gavreliuc, Ángel Gomez, Francesca Guizzo, Sylvie Graf, Hedy Greijdanus, Ani Grigoryan, Joanna Grzymała-Moszczyńska, Keltouma Guerch, Marie Gustafsson Sendén, Miriam-Linnea Hale, Hannah Hämer, Mika Hirai, Lam Hoang Duc, Martina Hřebíčková, Paul B. Hutchings, Dorthe Høj Jensen, Serdar Karabati, Kaltrina Kelmendi, Gabriella Kengyel, Narine Khachatryan, Rawan Ghazzawi, Mary Kinahan, Teri A. Kirby, Monika Kovacs, Desiree Kozlowski, Vladislav Krivoshchekov, Kuba Kryś, Clara Kulich, Tai Kurosawa, Nhan Thi Lac An, Javier Labarthe-Carrara, Mary Anne Lauri, Ioana Latu, Abiodun Musbau Lawal, Junyi Li, Jana Lindner, Anna Lindqvist, Angela T. Maitner, Elena Makarova, Ana Makashvili, Shera Malayeri, Sadia Malik, Tiziana Mancini, Claudia Manzi, Silvia Mari, Sarah E. Martiny, Claude-Hélène Mayer, Vladimir Mihić, Jasna MiloševićĐorđević, Eva Moreno-Bella, Silvia Moscatelli, Andrew Bryan Moynihan, Dominique Muller, Erita Narhetali, Félix Neto, Kimberly A. Noels, Boglárka Nyúl, Emma C. O’Connor, Danielle P. Ochoa, Sachiko Ohno, Sulaiman Olanrewaju Adebayo, Randall Osborne, Maria Giuseppina Pacilli, Jorge Palacio, Snigdha Patnaik, Vassilis Pavlopoulos, Pablo Pérez de León, Ivana Piterová, Juliana Barreiros Porto, Angelica Puzio, Joanna Pyrkosz-Pacyna, Erico Rentería Pérez, Emma Renström, Tiphaine Rousseaux, Michelle K. Ryan, Saba Safdar, Mario Sainz, Marco Salvati, Adil Samekin, Simon Schindler, A. Timur Sevincer, Masoumeh Seydi, Debra Shepherd, Sara Sherbaji, Toni Schmader, Cláudia Simão, Rosita Sobhie, Jurand Sobiecki, Lucille De Souza, Emma Sarter, Dijana Sulejmanović, Katie E. Sullivan, Mariko Tatsumi, Lucy Tavitian-Elmadjian, Suparna Jain Thakur, Quang Thi Mong Chi, Beatriz Torre, Ana Torres, Claudio V. Torres, Beril Türkoğlu, Joaquín Ungaretti, Timothy Valshtein, Colette Van Laar, Jolanda van der Noll, Vadym Vasiutynskyi, Christin-Melanie Vauclair, Neharika Vohra, Marta Walentynowicz, Colleen Ward, Anna Włodarczyk, Yaping Yang, Vincent Yzerbyt, Valeska Zanello, Antonella Ludmila Zapata-Calvente, Magdalena Zawisza, Rita Žukauskienė, Magdalena Żadkowska, Kosakowska-Berezecka, N, Bosson, J, Jurek, P, Besta, T, Olech, M, Vandello, J, Bender, M, Dandy, J, Hoorens, V, Jasinskaja-Lahti, I, Mankowski, E, Venäläinen, S, Abuhamdeh, S, Agyemang, C, Akbaş, G, Albayrak-Aydemir, N, Ammirati, S, Anderson, J, Anjum, G, Ariyanto, A, Aruta, J, Ashraf, M, Bakaitytė, A, Becker, M, Bertolli, C, Bërxulli, D, Best, D, Bi, C, Block, K, Boehnke, M, Bongiorno, R, Bosak, J, Casini, A, Chen, Q, Chi, P, Cubela Adoric, V, Daalmans, S, de Lemus, S, Dhakal, S, Dvorianchikov, N, Egami, S, Etchezahar, E, Esteves, C, Froehlich, L, Garcia-Sanchez, E, Gavreliuc, A, Gavreliuc, D, Gomez, Á, Guizzo, F, Graf, S, Greijdanus, H, Grigoryan, A, Grzymała-Moszczyńska, J, Guerch, K, Gustafsson Sendén, M, Hale, M, Hämer, H, Hirai, M, Hoang Duc, L, Hřebíčková, M, Hutchings, P, Jensen, D, Karabati, S, Kelmendi, K, Kengyel, G, Khachatryan, N, Ghazzawi, R, Kinahan, M, Kirby, T, Kovacs, M, Kozlowski, D, Krivoshchekov, V, Kryś, K, Kulich, C, Kurosawa, T, Lac An, N, Labarthe-Carrara, J, Lauri, M, Latu, I, Lawal, A, Li, J, Lindner, J, Lindqvist, A, Maitner, A, Makarova, E, Makashvili, A, Malayeri, S, Malik, S, Mancini, T, Manzi, C, Mari, S, Martiny, S, Mayer, C, Mihić, V, Miloševićđorđević, J, Moreno-Bella, E, Moscatelli, S, Moynihan, A, Muller, D, Narhetali, E, Neto, F, Noels, K, Nyúl, B, O’Connor, E, Ochoa, D, Ohno, S, Olanrewaju Adebayo, S, Osborne, R, Pacilli, M, Palacio, J, Patnaik, S, Pavlopoulos, V, de León, P, Piterová, I, Porto, J, Puzio, A, Pyrkosz-Pacyna, J, Rentería Pérez, E, Renström, E, Rousseaux, T, Ryan, M, Safdar, S, Sainz, M, Salvati, M, Samekin, A, Schindler, S, Sevincer, A, Seydi, M, Shepherd, D, Sherbaji, S, Schmader, T, Simão, C, Sobhie, R, Sobiecki, J, De Souza, L, Sarter, E, Sulejmanović, D, Sullivan, K, Tatsumi, M, Tavitian-Elmadjian, L, Thakur, S, Thi Mong Chi, Q, Torre, B, Torres, A, Torres, C, Türkoğlu, B, Ungaretti, J, Valshtein, T, Van Laar, C, van der Noll, J, Vasiutynskyi, V, Vauclair, C, Vohra, N, Walentynowicz, M, Ward, C, Włodarczyk, A, Yang, Y, Yzerbyt, V, Zanello, V, Zapata-Calvente, A, Zawisza, M, Žukauskienė, R, Żadkowska, M, and Veritati - Repositório Institucional da Universidade Católica Portuguesa

Subjects
Binary sex differences, Social Psychology, binary sex difference, 300 Social sciences, sociology & anthropology, Self-views, communality, agency, self-views, binary sex differences, egalitarianism, gender equality, Communication and Media, communality, Gender equality, Communality, Clinical Psychology, Egalitarianism, Agency, self-view, agency, egalitarianism, binary sex differences, self-views, 150 Psychology, gender equality, M-PSI/05 - PSICOLOGIA SOCIALE
Abstract

Social role theory posits that binary gender gaps in agency and communion should be larger in less egalitarian countries, reflecting these countries’ more pronounced sex-based power divisions. Conversely, evolutionary and self-construal theorists suggest that gender gaps in agency and communion should be larger in more egalitarian countries, reflecting the greater autonomy support and flexible self-construction processes present in these countries. Using data from 62 countries (N = 28,640), we examine binary gender gaps in agentic and communal self-views as a function of country-level objective gender equality (the Global Gender Gap Index) and subjective distributions of social power (the Power Distance Index). Findings show that in more egalitarian countries, gender gaps in agency are smaller and gender gaps in communality are larger. These patterns are driven primarily by cross-country differences in men’s self-views and by the Power Distance Index (PDI) more robustly than the Global Gender Gap Index (GGGI). We consider possible causes and implications of these findings., National Science Centre, Poland 2017/26/M/HS6/00360, United States Department of Health & Human Services, National Institutes of Health (NIH) - USA, NIH National Institute of General Medical Sciences (NIGMS) RL5GM118963, Universidad Nacional de Educacion a Distancia, Spain RTI2018-093550-B-I00, Grant Agency of the Czech Republic 20-01214S, Institute of Psychology, Czech Academy of Sciences RVO: 68081740, UK Research & Innovation (UKRI), Economic & Social Research Council (ESRC) ES/S00274X/1 MCIN/AEI PID2019-111549GB-I00, European Research Council (ERC) European Commission ERC-2016-COG 725128, Swedish Research Council Swedish Research Council for Health Working Life & Welfare (Forte) 2017-00414, University of Brasilia 04/2019

Published
2022
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196. Impact of number of [18F]fluorodeoxyglucose-PET-positive lymph nodes on survival of patients receiving neoadjuvant chemotherapy and surgery for oesophageal cancer.

Author

Miyata, H., Yamasaki, M., Makino, T., Tatsumi, M., Miyazaki, Y., Takahashi, T., Kurokawa, Y., Takiguchi, S., Mori, M., and Doki, Y.

Subjects
*ESOPHAGEAL cancer patients, *TREATMENT of esophageal cancer, *CANCER chemotherapy, *POSITRON emission tomography, *ADJUVANT treatment of cancer, *ESOPHAGEAL surgery
Abstract

Background: [18F]fluorodeoxyglucose (FDG)-PET has been used to evaluate the response of primary tumours to neoadjuvant therapy for oesophageal cancer. The clinical significance of the number of PET-positive nodes before and after therapy has not been investigated previously. Methods: [18F]FDG-PET was performed before and 2-3weeks after completion of neoadjuvant chemotherapy to identify the number of PET-positive nodes, and these numbers were assessed in relation to metabolic changes in the primary tumour. Results: Of 302 patients in total, 90 had no PET-positive nodes, 83 had one, 59 had two and 70 patients had three or more positive nodes before therapy. After treatment, the numbers were: none in 207 patients, one in 59, two in 20 and three or more in 16 patients. The number of PET-positive nodes after treatment was influenced by both the number of PET-positive nodes before therapy and the response to preoperative therapy, and correlated with the number of metastatic lymph nodes. Overall survival was longer in patients who had no PET-positive nodes after treatment than in those who had one ormore. Multivariable analysis identified the numbers of PET-positive nodes before and after chemotherapy as independent prognostic factors, together with clinical response, tumour depth and lymph node involvement. Conclusion: The number of PET-positive nodes after treatment correlated with survival in patients with oesophageal cancer who underwent neoadjuvant chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2016
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197. Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population.

Author

Kunugi, H., Hashimoto, R., Okada, T., Hori, H., Nakabayashi, T., Baba, A., Kudo, K., Omori, M., Takahashi, S., Tsukue, R., Anami, K., Hirabayashi, N., Kosuga, A., Tatsumi, M., Kamijima, K., Asada, T., Harada, S., Arima, K., and Saitoh, O.

Subjects
*GENETIC polymorphisms, *POPULATION genetics, *GENETIC regulation, *SCHIZOPHRENIA, *LYMPHOMAS, *NEURODEVELOPMENTAL treatment, *HUMAN genetic variation
Abstract

We examined, for the first time, the possible association between schizophrenia and the anaplastic lymphoma kinase (ALK) gene which plays an important role in neurodevelopment. When two nonsynonymous polymorphisms (Arg1491Lys and Glu1529Asp) were examined, there were significant differences in genotype and allele distributions between patients and controls. Individuals homozygous for the minor allele (1491Lys–1529Asp) were more common in patients than in controls (p = 0.0064, odds ratio 2.4, 95% CI 1.3–4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2006
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198. A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity.

Author

Okada, T., Hashimoto, R., Numakawa, T., Iijima, Y., Kosuga, A., Tatsumi, M., Kamijima, K., Kato, T., and Kunugi, H.

Subjects
*GENETIC polymorphisms, *NEUROTROPHINS, *BIPOLAR disorder, *NEUROPSYCHIATRY, *MENTAL health
Abstract

Previous studies have suggested that genetic variations in the brain-derived neurotrophic factor (BDNF) gene may be associated with several neuropsychiatric diseases including bipolar disorder. The present study examined a microsatellite polymorphism located approximately 1.0 kb upstream of the translation initiation site of the BDNF gene for novel sequence variations, association with bipolar disorder, and effects on transcriptional activity. Detailed sequencing analysis revealed that this polymorphism is not a simple dinucleotide repeat, but it is highly polymorphic with a complex structure containing three types of dinucleotide repeats, insertion/deletion, and nucleotide substitutions that gives rise to a total of 23 novel allelic variants. We obtained evidence supporting the association between this polymorphic region (designated as BDNF-linked complex polymorphic region (BDNF-LCPR)) and bipolar disorder. One of the major alleles (‘A1’ allele) was significantly more common in patients than in controls (odds ratio 2.8, 95% confidential interval 1.5–5.3, P=0.001). Furthermore, a luciferase reporter gene assay in rat primary cultured neurons suggests that this risk allele (A1) has a lower-transcription activity, compared to the other alleles. Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene.Molecular Psychiatry (2006) 11, 695–703. doi:10.1038/sj.mp.4001822; published online 28 March 2006 [ABSTRACT FROM AUTHOR]

Published
2006
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199. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.

Author

Hashimoto, R., Suzuki, T., Iwata, N., Yamanouchi, Y., Kitajima, T., Kosuga, A., Tatsumi, M., Ozaki, N., Kamijima, K., and Kunugi, H.

Subjects
*SCHIZOPHRENIA, *MOOD (Psychology), *AFFECTIVE disorders, *GENETICS, *BIPOLAR disorder, *NUCLEOTIDES, *GENETIC polymorphisms
Abstract

Two research groups have recently reported a significant association between schizophrenia and genetic variants of Frizzled-3 (FZD3) gene. We examined a possible association in a Japanese sample of schizophrenia, bipolar disorder, unipolar depression and controls with four single nucleotide polymorphisms (SNPs), tested in previous reports. We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample. [ABSTRACT FROM AUTHOR]

Published
2005
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200. Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia.

Author

Hashimoto, R., Yoshida, M., Ozaki, N., Yamanouchi, Y., Iwata, N., Suzuki, T., Kitajima, T., Tatsumi, M., Kamijima, K., and Kunugi, H.

Subjects
*SCHIZOPHRENIA, *GENETIC polymorphisms, *GENES, *TUMOR necrosis factors, *PSYCHOSES, *POPULATION genetics
Abstract

Summary. Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene. [ABSTRACT FROM AUTHOR]

Published
2004
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