346 results on '"Thomas, Michael S. C."'
Search Results
152. Mechanisms of developmental regression in autism and the broader phenotype: A neural network modeling approach.
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Thomas, Michael S. C., primary, Knowland, Victoria C. P., additional, and Karmiloff-Smith, Annette, additional
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- 2011
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153. Definitions versus categorization: assessing the development of lexico-semantic knowledge in Williams syndrome
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Purser, Harry R. M., primary, Thomas, Michael S. C., additional, Snoxall, Sarah, additional, Mareschal, Denis, additional, and Karmiloff-Smith, Annette, additional
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- 2010
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154. Neuronal Activation for Semantically Reversible Sentences
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Richardson, Fiona M., primary, Thomas, Michael S. C., additional, and Price, Cathy J., additional
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- 2010
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155. Contrasting Effects of Vocabulary Knowledge on Temporal and Parietal Brain Structure across Lifespan
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Richardson, Fiona M., primary, Thomas, Michael S. C., additional, Filippi, Roberto, additional, Harth, Helen, additional, and Price, Cathy J., additional
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- 2010
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156. What Is Typical Language Development?
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Thomas, Michael S. C., primary, Karaminis, Themis N., additional, and Knowland, Victoria C. P., additional
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- 2010
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157. Development of motion processing in children with autism
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Annaz, Dagmara, primary, Remington, Anna, additional, Milne, Elizabeth, additional, Coleman, Mike, additional, Campbell, Ruth, additional, Thomas, Michael S. C., additional, and Swettenham, John, additional
- Published
- 2009
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158. The development of similarity: Testing the prediction of a computational model of metaphor comprehension
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Purser, Harry R. M., primary, Thomas, Michael S. C., additional, Snoxall, Sarah, additional, and Mareschal, Denis, additional
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- 2009
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159. Using Developmental Trajectories to Understand Developmental Disorders
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Thomas, Michael S. C., primary, Annaz, Dagmara, additional, Ansari, Daniel, additional, Scerif, Gaia, additional, Jarrold, Chris, additional, and Karmiloff-Smith, Annette, additional
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- 2009
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160. COMPETITION AS A MECHANISM FOR PRODUCING SENSITIVE PERIODS IN CONNECTIONIST MODELS OF DEVELOPMENT
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THOMAS, MICHAEL S. C., primary
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- 2009
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161. Studying development in the 21st Century
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Thomas, Michael S. C., primary, Westermann, Gert, additional, Mareschal, Denis, additional, Johnson, Mark H., additional, Sirois, Sylvain, additional, and Spratling, Michael, additional
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- 2008
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162. Précis of Neuroconstructivism: How the Brain Constructs Cognition
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Sirois, Sylvain, primary, Spratling, Michael, additional, Thomas, Michael S. C., additional, Westermann, Gert, additional, Mareschal, Denis, additional, and Johnson, Mark H., additional
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- 2008
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163. Computational Modeling in Developmental Psychology
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Mareschal, Denis, primary and Thomas, Michael S. C., additional
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- 2007
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164. Neuroconstructivism - IHow the brain constructs cognition
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Mareschal, Denis, primary, Johnson, Mark H., additional, Sirois, Sylvain, additional, Spratling, Michael, additional, Thomas, Michael S. C., additional, and Westermann, Gert, additional
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- 2007
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165. Speeded naming, frequency and the development of the lexicon in Williams syndrome
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Thomas, Michael S. C., primary, Dockrell, Julie E., additional, Messer, David, additional, Parmigiani, Charlotte, additional, Ansari, Daniel, additional, and Karmiloff-Smith, Annette, additional
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- 2006
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166. The computational modeling of sensitive periods
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Thomas, Michael S. C., primary and Johnson, Mark H., additional
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- 2006
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167. How Do Simple Connectionist Networks Achieve a Shift From “Featural” to “Correlational” Processing in Categorization?
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Thomas, Michael S. C., primary
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- 2004
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168. VARIABILITY IN THE SEVERITY OF DEVELOPMENTAL DISORDERS: A NEUROCOMPUTATIONAL ACCOUNT OF DEVELOPMENTAL REGRESSION IN AUTISM.
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THOMAS, MICHAEL S. C., KNOWLAND, VICTORIA C. P., and KARMILOFF-SMITH, ANNETTE
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AUTISM ,NEURODEVELOPMENTAL treatment ,OCCUPATIONAL therapy ,PHYSICAL therapy ,GENETIC disorders - Published
- 2011
169. Essay Review: Limits on plasticity
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Thomas, Michael S. C., primary
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- 2003
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170. Development as a Cause in Developmental Disorders: (Commentary on “Control and Cross‐Domain Mental Computation: Evidence from Language Breakdown” by William Frawley)
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Thomas, Michael S. C., primary
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- 2002
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171. Modeling Typical and Atypical Cognitive Development: Computational Constraints on Mechanisms of Change
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Thomas, Michael S. C., primary and Karmiloff‐Smith, Annette, additional
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- 2002
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172. Metaphor as Categorization: A Connectionist Implementation
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Thomas, Michael S. C., primary and Mareschal, Denis, additional
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- 2001
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173. Language switching in bilingual production: Empirical data and computational modelling.
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FILIPPI, ROBERTO, KARAMINIS, THEMIS, and THOMAS, MICHAEL S. C.
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LANGUAGE & languages ,BILINGUALISM ,EMPIRICAL research ,DATA analysis ,LEARNING ,DECISION making - Abstract
One key issue in bilingualism is how bilinguals control production, particularly to produce words in the less dominant language. Language switching is one method to investigate control processes. Language switching has been much studied in comprehension, e.g., in lexical decision task, but less so in production. Here we first present a study of language switching in Italian-English adult bilinguals in a naming task for visually presented words. We demonstrate an asymmetric pattern of time costs to switch language, where participants incurred a greater time cost to switch into naming in their dominant language (Italian). In addition, costs were greater where the stimuli were interlingual cognates or homographs than words existing in only one language, implicating lexical competition as a source of the cost. To clarify the operation of control processes, we then present two connectionist models of bilingual naming, based on the previous models of Seidenberg and McClelland (1989), Cohen, Dunbar and McClelland (1990), Gilbert and Shallice (2002), and Karaminis and Thomas (2010). Crucially, both models acquired their differential language dominance via an experience-dependent learning process. The models embody different assumptions about the language control processes that produce the switch cost. We consider which processing assumptions are sufficient to explain asymmetric language switch costs and word class effects on language switching in individual word reading, as well as generating novel predictions for future testing. [ABSTRACT FROM AUTHOR]
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- 2014
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174. Quantities of qualia
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Thomas, Michael S. C., primary and Atkinson, Anthony P., additional
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- 1999
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175. The Right Posterior Paravermis and the Control of Language Interference.
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Filippi, Roberto, Richardson, Fiona M., Dick, Frederic, Leech, Robert, Green, David W., Thomas, Michael S. C., and Price, Cathy J.
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COMPREHENSION ,NEUROSCIENCES ,BRAIN ,LANGUAGE ability ,MEDICAL sciences - Abstract
Auditory and written language in humans' comprehension necessitates attention to the message of interest and suppression of interference from distracting sources. Investigating the brain areas associated with the control of interference is challenging because it is inevitable that activation of the brain regions that control interference co-occurs with activation related to interference per se. To isolate the mechanisms that control verbal interference, we used a combination of structural and functional imaging techniques in Italian and German participants who spoke English as a second language. First, we searched structural MRI images of Italian participants for brain regions in which brain structure correlated with the ability to suppress interference from the unattended dominant language (Italian) while processing heard sentences in their weaker language (English). This revealed an area in the posterior paravermis of the right cerebellum in which gray matter density was higher in individuals who were better at controlling verbal interference. Second, we found functional activation in the same regionwhenourGermanparticipantsmadesemantic decisions on written English words in the presence of interference from unrelated words in their dominant language (German). This combination of structural and functional imaging therefore highlights the contribution of the right posterior paravermis to the control of verbal interference. We suggest that the importance of this region for language processing has previously been missed because most fMRI studies limit the field of view to increase sensitivity, with the lower part of the cerebellum being the region most likely to be excluded. [ABSTRACT FROM AUTHOR]
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- 2011
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176. Multiple Routes from Occipital to Temporal Cortices during Reading.
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Richardson, Fiona M., Seghier, Mohamed L., Leff, Alex P., Thomas, Michael S. C., and Price, Cathy J.
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Contemporary models of the neural system that supports reading propose that activity in a ventral occipitotemporal area (vOT) drives activity in higher-order language areas, for example, those in the posterior superior temporal sulcus (pSTS) and anterior superior temporal sulcus (aSTS). We used fMRI with dynamic causal modeling (DCM) to investigate evidence for other routes from visual cortex to the left temporal lobe language areas. First we identified activations in posterior inferior occipital (iO) and vOT areas that were more activated for silent reading than listening to words and sentences; and in pSTS and aSTS areas that were commonly activated for reading relative to false-fonts and listening to words relative to reversed words. Second, in three different DCM analyses, we tested whether visual processing of words modulates activity from the following: (1) iO→vOT, iO→pSTS, both, or neither; (2) vOT→pSTS, iO→pSTS, both or neither; and (3) pSTS→aSTS, vOT→aSTS, both, or neither. We found that reading words increased connectivity (1) from iO to both pSTS and vOT; (2) to pSTS from both iO and vOT; and (3) to aSTS from both vOT and pSTS. These results highlight three potential processing streams in the occipitotemporal cortex: iO→pSTS→aSTS; iO→vOT→aSTS; and iO→vOT→pSTS→aSTS. We discuss these results in terms of cognitive models of reading and propose that efficient reading relies on the integrity of all these pathways. [ABSTRACT FROM AUTHOR]
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- 2011
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177. Definitions versus categorization: assessing the development of lexico-semantic knowledge in Williams syndrome.
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Purser, Harry R. M., Thomas, Michael S. C., Snoxall, Sarah, Mareschal, Denis, and Karmiloff‐Smith, Annette
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WILLIAMS syndrome , *AGE distribution , *ANALYSIS of covariance , *COGNITION , *COMPARATIVE studies , *INTELLECT , *LANGUAGE acquisition , *PROJECTIVE techniques , *RESEARCH , *RESEARCH funding , *SEMANTICS , *VOCABULARY , *CONTROL groups , *REPEATED measures design , *DIAGNOSIS - Abstract
Background: Williams syndrome (WS) is associated with relatively strong language abilities despite mild to moderate intellectual disability, particularly when language is indexed by vocabulary. Aims: The aim of the study was twofold: (1) to investigate whether reported lexical anomalies in WS can be explained with reference to anomalous semantic development; and (2) to assess whether receptive vocabulary skills in WS, a relative strength, are underpinned by commensurate semantic knowledge. Methods & Procedures: The development of lexical-semantic knowledge was investigated in 45 typically developing individuals (chronological age range = 5-10 years, mental age range = 5-13 years) and 15 individuals with WS (chronological age range = 12-50 years, mental age range = 4-17 years) by means of (1) a categorization task and (2) a definitions task, which was expected to make additional metacognitive demands. Outcomes & Results: At younger ages, the performance level of typically developing individuals and individuals with WS did not differ on the definitions task. However, the WS group's ability to define words fell away from the level predicted by the typically developing group at older ages, as more sophisticated definitions were expected. The results of the categorization task indicated that individuals with WS had less lexical-semantic knowledge than expected given their level of receptive vocabulary, although from this lower level the knowledge then developed at a similar rate to that found in typical development. Conclusions & Implications: It is concluded, first, that conventional vocabulary measures may overestimate lexical-semantic knowledge in WS; and, second, concerns about the metacognitive demands of the definitions task when used with atypical populations may be well founded. [ABSTRACT FROM AUTHOR]
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- 2011
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178. DEVELOPMENTAL TRAJECTORIES IN GENETIC DISORDERS.
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Knowland, Victoria C. P. and Thomas, Michael S. C.
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DEVELOPMENTAL biology ,HUMAN beings ,PHYSIOLOGICAL aspects of learning ,SEMANTIC memory ,WILLIAMS syndrome ,FACE perception in children ,DYSLEXIA - Abstract
The article discusses the role of age as a factor determining the developmental changes in a human being from childhood to adulthood. As stated, learning disability is associated with genetic condition of the human being. Further three examples using trajectory approach are cited that includes semantic knowledge in Williams syndrome, development of face recognition differing with age and audiovisual processing in developmental dyslexia.
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- 2011
179. Development of motion processing in children with autism Dagmara Annaz et al. Development of motion processing in children with autism.
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Annaz, Dagmara, Remington, Anna, Milne, Elizabeth, Coleman, Mike, Campbell, Ruth, Thomas, Michael S. C., and Swettenham, John
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AUTISTIC children ,AUTISM ,CHILD development ,CHILDREN'S health ,MEDICAL sciences - Abstract
Recent findings suggest that children with autism may be impaired in the perception of biological motion from moving point-light displays. Some children with autism also have abnormally high motion coherence thresholds. In the current study we tested a group of children with autism and a group of typically developing children aged 5 to 12 years of age on several motion perception tasks, in order to establish the specificity of the biological motion deficit in relation to other visual discrimination skills. The first task required the recognition of biological from scrambled motion. Three quasi-psychophysical tasks then established individual thresholds for the detection of biological motion in dynamic noise, of motion coherence and of form-from-motion. Lastly, individual thresholds for a task of static perception - contour integration (Gabor displays) - were also obtained. Compared to controls, children with autism were particularly impaired in processing biological motion in relation to any developmental measure (chronological or mental age). In contrast, there was some developmental overlap in ability to process other types of visual motion between typically developing children and the children with autism, and evidence of developmental change in both groups. Finally, Gabor display thresholds appeared to develop typically in children with autism. [ABSTRACT FROM AUTHOR]
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- 2010
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180. Limits on plasticity.
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Thomas, Michael S. C.
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COGNITIVE neuroscience , *NEUROPLASTICITY , *BRAIN damage - Abstract
The more scientists learn about the brain, the more we learn about its infinite plasticity. … If there is a challenge to one part of the brain, we can learn to revive other parts to make all sections of the mind work together. (Elaine Colliar, “mind-mapping” champion, on how a visualization technique might be used to overcome reading impairments in developmental dyslexia; BBC News Online, Kenyon, 2002). We should encourage the public's interest in developmental brain science and applaud attempts to base early childhood policy and practice on a scientific basis. However, in some instances, public enthusiasm far outstrips our scientific understanding. Too often the messages broadcast by advocates and the media do not accurately reflect what scientists currently know about synapses, critical periods, neural plasticity, and how experience affects the brain. (Bruer, 2001, p. x) [ABSTRACT FROM AUTHOR]
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- 2003
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181. The impact of multilingualism and socio-economic status on academic performance: evidence from the SCAMP and the national pupil databases.
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Filippi, Roberto, Ceccolini, Andrea, Perry, Roisin C., and Thomas, Michael S. C.
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This study examines the impact of multilingualism and socioeconomic status on academic performance within the UK, utilising data from 3,213 pupils from the National Pupil Database who also took part in the Study of Cognition, Adolescents and Mobile Phones (SCAMP). We employed multilevel modelling to analyse the relationship between language experience, socioeconomic status and Key-Stage 2 (KS2∼11 years) and Key-Stage 4 (KS4∼16 years) performance in English, Mathematics and Science. Findings reveal that multilingual learners initially face academic challenges at KS2, particularly in English and Science, but achieve comparable results with monolingual peers by KS4, overcoming early setbacks. Notably, simultaneous multilinguals not only catch up but excel beyond their monolingual counterparts by KS4, demonstrating the significant long-term academic benefits of early multilingual exposure and /or its associated cultural factors. Further analysis indicates that multilingual group membership mitigated the adverse effects of low socioeconomic status, with pupils from these backgrounds making substantial academic strides between KS2 and KS4 compared to monolingual peers. This challenges prevalent misconceptions about multilingualism in education. These findings underscore the need for educational policies that harness linguistic diversity to foster academic equity and success, emphasising the crucial role of language experience and socioeconomic factors in shaping educational outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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182. Twenty‐four‐month effortful control predicts emerging autism characteristics.
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Perry, Roisin C., Johnson, Mark H., Charman, Tony, Pascoe, Greg, Tolmie, Andrew, Thomas, Michael S. C., Dumontheil, Iroise, and Jones, Emily J. H.
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CONTROL (Psychology) , *INCOME , *LONGITUDINAL method , *SOCIOECONOMIC factors , *AUTISM - Abstract
Research Highlights Longitudinal research can assess how diverging development of multiple cognitive skills during infancy, as well as familial background, are related to the emergence of neurodevelopmental conditions. Sensorimotor and effortful control difficulties are seen in infants later diagnosed with autism; this study explored the relationships between these skills and autism characteristics in 340 infants (240 with elevated familial autism likelihood) assessed at 4–7, 8–10, 12–15, 24, and 36 months. We tested: (1) the relationship between parent‐reported effortful control (Rothbart's temperament questionnaires) and sensorimotor skills (Mullen Scales of Early Learning), using random intercept cross‐lagged panel modelling; (2) whether household income and maternal education predicted stable individual differences in cognition; (3) sensorimotor and effortful control skills as individual and interactive predictors of parent‐reported autism characteristics (Social Responsiveness Scale) at 3 years, using multiple regression; and (4) moderation of interactions by familial likelihood. Sensorimotor skills were longitudinally associated with effortful control at the subsequent measurement point from 12–15 months. Socioeconomic status indicators did not predict stable between‐infant differences in sensorimotor or effortful control skills. Effortful control skills were longitudinally related to 3‐year autism characteristics from the first year of life, with evidence for an interaction with sensorimotor skills at 24 months. Effects of effortful control increased with age and were particularly important for infants with family histories of autism. Results are discussed in relation to different theoretical frameworks: Developmental Cascades and Anterior Modifiers in the Emergence of Neurodevelopmental Disorders. We suggest a role for 24‐month effortful control in explaining the emergent autism phenotype. Sensorimotor skills longitudinally predicted effortful control from 12–15 months onward but effortful control did not longitudinally predict sensorimotor skills during infancy. Measures of effortful control skills taken before the age of 1 predicted continuous variation in autism characteristics at 36 months, with associations increasing in strength with age. Effortful control (measured at 12–15 and 24 months) was a stronger predictor of 36‐month autism characteristics in infants with elevated familial likelihood for autism. The relationship between 24‐month sensorimotor skills and 36‐month autism characteristics was stronger in infants with weaker effortful control skills. [ABSTRACT FROM AUTHOR]
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- 2024
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183. Theories that develop
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Thomas, Michael S. C.
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The target article represents a significant advance in the level of sophistication applied to models of bilingual word recognition, and Dijkstra and van Heuven are to be congratulated on this endeavour. Bearing in mind the success of the (computational) BIA model in capturing detailed patterns of experimental data, I look forward to future simulation results from the BIA+ when the proposals of this new framework are implemented. It is an essential step to draw a distinction between recognition systems and the decision mechanisms that drive responses, and the authors have provided a novel way of apportioning empirical evidence of context effects in bilingual word recognition across this divide. Given the explanatory weight now being placed on decision mechanisms rather than the word recognition system itself, perhaps indeed it is now time to make some simplifying assumptions about the recognition system and start building detailed computational models of the decision component of the system. Implementation will provide the clarity of theorisation and evaluation of theory viability that have been the hallmark of the BIA model thus far.
- Published
- 2002
184. Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome.
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D'Souza, Hana, Mason, Luke, Mok, Kin Y., Startin, Carla M., Hamburg, Sarah, Hithersay, Rosalyn, Baksh, R. Asaad, Hardy, John, Strydom, Andre, and Thomas, Michael S. C.
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- 2020
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185. Rule extraction from autoencoder‐based connectionist computational models.
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Yang, Juan, Thomas, Michael S. C., and Liu, Hongtao
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RULE extraction (Machine learning) ,COMPUTATIONAL complexity ,NATURAL language processing ,COMPUTER simulation ,PROBLEM solving - Abstract
Summary: Mapping problems are typical research topics related to natural language learning, and they include not only classification mappings but also nonclassification mappings, such as verbs and their past tenses. Connectionist computational models are one of the most popular approaches for simulating those mapping problems; however, their lack of explanatory ability has prevented them from being further used to understand the language learning process. Therefore, the work of extracting rational rules from a connectionist model is as important as simulating the mapping behaviors. Unfortunately, there is no available technique that can be directly applied in those computational models to simulate nonclassification problems. In this paper, an autoencoder‐based connectionist computational model is proposed to derive a rule extraction method that can construct "If‐Then" rational relations with high fidelity for nonclassification mapping problems. To demonstrate its generalizability, this computational model is extended to a modified version to address a multi‐label classification mapping problem related to cognitive style prediction. Experiments prove this computational model's simulation ability and its explanatory ability on nonclassification problems by comparing its fidelity performances with those of the classical connectionist computational model (multilayer perceptron artificial neural network), and its similar ability on a multi‐label classification problem (Felder‐Silverman learning style classification) by comparing its prediction accuracy with those of other rule induction techniques. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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186. Cohort Profile: The Study of Cognition, Adolescents and Mobile Phones (SCAMP).
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Toledano, Mireille B, Mutz, Julian, Röösli, Martin, Thomas, Michael S C, Dumontheil, Iroise, and Elliott, Paul
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CELL phones ,PUBLIC health ,MEDICAL care ,MENTAL health ,ADOLESCENT health - Published
- 2019
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187. Aligning cognitive studies in mouse models and human infants/toddlers
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The LonDownS Consortium, Souza, Hana D., Daniel Brady, Wiseman, Frances K., Good, Mark A., Thomas, Michael S. C., Andre Strydom, Elizabeth Fisher, Dean Nizetic, John Hardy, Victor Tybulewicz, Annette Karmiloff-Smith, Michael Thomas, and Denis Mareschal
188. Annette Karmiloff-Smith 1938-2016.
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Thomas, Michael S. C.
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SCIENTISTS - Abstract
An obituary for professor Annette Karmiloff-Smith, a developmental and cognitive scientist, is presented.
- Published
- 2017
189. Are imaging and lesioning convergent methods for assessing functional specialisation?: investigations using an artificial neural network.
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Thomas MS, Purser HR, Tomlinson S, Mareschal D, Thomas, Michael S C, Purser, Harry R M, Tomlinson, Simon, and Mareschal, Denis
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This article presents an investigation of the relationship between lesioning and neuroimaging methods of assessing functional specialisation, using synthetic brain imaging (SBI) and lesioning of a connectionist network of past-tense formation. The model comprised two processing 'routes': one was a direct route between layers of input and output units, while the other, indirect, route featured an intermediate layer of processing units. Emergent specialisation within the network was assessed (1) by lesioning either the direct or indirect route and measuring past-tense performance for regular and irregular verbs, and (2) by measuring functional activation in each route when processing each verb type (SBI). SBI and lesioning approaches failed to converge when network activation was summed over each route in our SBI approach. Examination of individual network solutions suggested that the verb types might be using the indirect route differently in terms of the pattern of activation across the route, rather than in terms of gross activation. A subsequent SBI analysis compared patterns of activation in the indirect route and confirmed that these patterns were more similar between regular-type verbs than between regular and irregular verbs. As the spatial and temporal resolution of neuroimaging techniques improves, the results of this investigation suggest that the key to finding functional specialisation will be to distinguish local coding differences across behaviours that are the results of developmental processes. Other analyses suggest that lesioning data may be limited because, with increasing damage, they reveal the resting activations of a computational system rather than a computational specialisation per se. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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190. Sex-specific behavioural deficits in adulthood following acute activation of the GABAA receptor in the neonatal mouse.
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Goikolea-Vives A, Fernandes C, Thomas MSC, Thornton C, and Stolp HB
- Abstract
Introduction: Sex differences exist in the prevalence of neurodevelopmental disorders (NDDs). Part of the aetiology of NDDs has been proposed to be alterations in the balance between excitatory and inhibitory neurotransmission, leading to the question of whether males and females respond differently to altered neurotransmitter balance. We investigated whether pharmacological alteration of GABAA signalling in early development results in sex-dependent changes in adult behaviours associated with NDDs., Methods: Male and female C57BL/6J mice received intraperitoneal injections of 0.5mg/kg muscimol or saline on postnatal days (P) 3-5 and were subjected to behavioural testing, specifically open field, light dark box, marble burying, sucralose preference, social interaction and olfactory habituation/dishabituation tests between P60-90., Results: Early postnatal administration of muscimol resulted in reduced anxiety in the light dark box test in both male and female adult mice. Muscimol reduced sucralose preference in males, but not females, whereas female mice showed reduced social behaviours. Regional alterations in cortical thickness were observed in the weeks following GABAA receptor activation, pointing to an evolving structural difference in the brain underlying adult behaviour., Conclusions: We conclude that activation of the GABAA receptor in the first week of life resulted in long-lasting changes in a range of behaviours in adulthood following altered neurodevelopment. Sex of the individual affected the nature and severity of these abnormalities, explaining part of the varied pathophysiology and neurodevelopmental diagnosis that derive from excitatory/inhibitory imbalance., (The Author(s). Published by S. Karger AG, Basel.)
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- 2024
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191. Cross-sectional and longitudinal assessment of cognitive development in Williams syndrome.
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Farran EK, Purser HRM, Jarrold C, Thomas MSC, Scerif G, Stojanovik V, and Van Herwegen J
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- Adult, Child, Adolescent, Humans, Cross-Sectional Studies, Cognition, Aptitude, Williams Syndrome psychology
- Abstract
Williams syndrome (WS) is a rare genetic syndrome. As with all rare syndromes, obtaining adequately powered sample sizes is a challenge. Here we present legacy data from seven UK labs, enabling the characterisation of cross-sectional and longitudinal developmental trajectories of verbal and non-verbal development in the largest sample of individuals with WS to-date. In Study 1, we report cross-sectional data between N = 102 and N = 209 children and adults with WS on measures of verbal and non-verbal ability. In Study 2, we report longitudinal data from N = 17 to N = 54 children and adults with WS who had been tested on at least three timepoints on these measures. Data support the WS characteristic cognitive profile of stronger verbal than non-verbal ability, and shallow developmental progression for both domains. Both cross-sectional and longitudinal data demonstrate steeper rates of development in the child participants than the adolescent and adults in our sample. Cross-sectional data indicate steeper development in verbal than non-verbal ability, and that individual differences in the discrepancy between verbal and non-verbal ability are largely accounted for by level of intellectual functioning. A diverging developmental discrepancy between verbal and non-verbal ability, whilst marginal, is not mirrored statistically in the longitudinal data. Cross-sectional and longitudinal data are discussed with reference to validating cross-sectional developmental patterns using longitudinal data and the importance of individual differences in understanding developmental progression., (© 2023 The Authors. Developmental Science published by John Wiley & Sons Ltd.)
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- 2024
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192. Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
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Murray A, Gough G, Cindrić A, Vučković F, Koschut D, Borelli V, Petrović DJ, Bekavac A, Plećaš A, Hribljan V, Brunmeir R, Jurić J, Pučić-Baković M, Slana A, Deriš H, Frkatović A, Groet J, O'Brien NL, Chen HY, Yeap YJ, Delom F, Havlicek S, Gammon L, Hamburg S, Startin C, D'Souza H, Mitrečić D, Kero M, Odak L, Krušlin B, Krsnik Ž, Kostović I, Foo JN, Loh YH, Dunn NR, de la Luna S, Spector T, Barišić I, Thomas MSC, Strydom A, Franceschi C, Lauc G, Krištić J, Alić I, and Nižetić D
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- Adult, Humans, Aging, Cell Differentiation, Dyrk Kinases, Down Syndrome genetics, Induced Pluripotent Stem Cells
- Abstract
Background: People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential actions of individual supernumerary chromosome-21 genes. The latter explanation could open a route to therapeutic amelioration if the specific over-acting genes could be identified and their action toned-down., Methods: Biological age was estimated through patterns of sugar molecules attached to plasma immunoglobulin-G (IgG-glycans, an established "biological-ageing-clock") in n = 246 individuals with DS from three European populations, clinically characterised for the presence of co-morbidities, and compared to n = 256 age-, sex- and demography-matched healthy controls. Isogenic human induced pluripotent stem cell (hiPSCs) models of full and partial trisomy-21 with CRISPR-Cas9 gene editing and two kinase inhibitors were studied prior and after differentiation to cerebral organoids., Findings: Biological age in adults with DS is (on average) 18.4-19.1 years older than in chronological-age-matched controls independent of co-morbidities, and this shift remains constant throughout lifespan. Changes are detectable from early childhood, and do not require a supernumerary chromosome, but are seen in segmental duplication of only 31 genes, along with increased DNA damage and decreased levels of LaminB1 in nucleated blood cells. We demonstrate that these cell-autonomous phenotypes can be gene-dose-modelled and pharmacologically corrected in hiPSCs and derived cerebral organoids. Using isogenic hiPSC models we show that chromosome-21 gene DYRK1A overdose is sufficient and necessary to cause excess unrepaired DNA damage., Interpretation: Explanation of hitherto observed accelerated ageing in DS as a developmental progeroid syndrome driven by DYRK1A overdose provides a target for early pharmacological preventative intervention strategies., Funding: Main funding came from the "Research Cooperability" Program of the Croatian Science Foundation funded by the European Union from the European Social Fund under the Operational Programme Efficient Human Resources 2014-2020, Project PZS-2019-02-4277, and the Wellcome Trust Grants 098330/Z/12/Z and 217199/Z/19/Z (UK). All other funding is described in details in the "Acknowledgements"., Competing Interests: Declaration of interests GL is the founder and owner of Genos Ltd., a private research organisation that specialises in high-throughput glycomic analyses and has several patents in this field and is also a shareholder in GlycanAge Ltd., a company that sells the GlycanAge test of biological age. AC, FV, JJ, MPB, ASla, HD, AF, DP and JK are employees of Genos Ltd. AStr has served on the Advisory Boards of AC Immune and ProMIS Neuroscience, and is a past president of the Trisomy21 Research Society. TS is the scientific co-founder and a shareholder of Zoe Ltd., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2023
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193. Complex cognition and individual variability: a mixed methods study of the relationship between creativity and executive control.
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Rogers CJ, Tolmie A, Massonnié J, and Thomas MSC
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One of the methodological challenges of educational neuroscience is understanding real world cognition in the multifaceted environment of the classroom. Complex cognition does not simplify to processes (which might be satisfactorily measured in the lab) but to sets of activities, likely to vary between individuals, which involve the iterative use of multiple processes, as well as the environment, over an extended period of time. As such, studying complex cognition requires methodological flexibility; any single method is unlikely to provide complete answers. We illustrate this idea with our research exploring the relationship between executive control (EC) and creativity in primary school age children; in it, we used both qualitative and quantitative tools and a novel approach to bringing both sets of findings together. Quantitative findings helped inform 'how much' a participant could deploy EC or creative thinking, while qualitative findings told us more about 'how' they deployed EC in their creativity. Through triangulating findings, we gained insights which would have remained obscure using either approach alone; namely, first, that wide variation in how children deploy EC in creativity means that the same creative results can be achieved with very different levels of EC involvement, and second, that high levels of EC can limit creativity. We argue that, beyond the specific findings of this study, there might be useful broader methodological lessons for educational neuroscience. We also attempt to demystify mixed methods by showing that a multi-pronged approach is more feasible than many assume; for example, by using existing, familiar tools in novel ways. In our work, we redeployed well-established quantitative tests used in creativity research as stimuli for qualitative investigation. For educational neuroscience to evolve its understanding of complex cognition, we suggest it might benefit from being innovative, open-minded and ambitious in how it exploits the diversity of methodological tools available., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Rogers, Tolmie, Massonnié and Thomas.)
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- 2023
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194. A systematic review of cognitive interventions for adult patients with brain tumours.
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Kirkman MA, Ekert JO, Hunn BHM, Thomas MSC, and Tolmie AK
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- Adult, Humans, Quality of Life, Cognition, Cognitive Dysfunction etiology, Cognitive Dysfunction therapy, Cognition Disorders, Brain Neoplasms complications, Brain Neoplasms therapy
- Abstract
Background: Neurocognitive impairments are common in patients with current or previously treated brain tumours, and such impairments can negatively affect patient outcomes including quality of life and survival. This systematic review aimed to identify and describe interventions used to ameliorate (improve) or prevent cognitive impairments in adults with brain tumours., Methods: We performed a literature search of the Ovid MEDLINE, PsychINFO and PsycTESTS databases from commencement until September 2021., Results: In total, 9998 articles were identified by the search strategy; an additional 14 articles were identified through other sources. Of these, 35 randomised and nonrandomised studies were deemed to meet the inclusion/exclusion criteria of our review and were subsequently included for evaluation. A range of interventions were associated with positive effects on cognition, including pharmacological agents such as memantine, donepezil, methylphenidate, modafinil, ginkgo biloba and shenqi fuzheng, and nonpharmacological interventions such as general and cognitive rehabilitation, working memory training, Goal Management Training, aerobic exercise, virtual reality training combined with computer-assisted cognitive rehabilitation, hyperbaric oxygen therapy and semantic strategy training. However, most identified studies had a number of methodological limitations and were judged to be at moderate-to-high risk of bias. In addition, it remains unclear whether and to what extent the identified interventions lead to durable cognitive benefits after cessation of the intervention., Conclusion: The 35 studies identified in this systematic review have indicated potential cognitive benefits for a number of pharmacological and nonpharmacological interventions in patients with brain tumours. Study limitations were identified and further studies should focus on improved study reporting, methods to reduce bias and minimise participant drop-out and withdrawal where possible, and consider standardisation of methods and interventions across studies. Greater collaboration between centres could result in larger studies with standardised methods and outcome measures, and should be a focus of future research in the field., (© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
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- 2023
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195. Associations between Socioeconomic Status, Cognition, and Brain Structure: Evaluating Potential Causal Pathways Through Mechanistic Models of Development.
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Thomas MSC and Coecke S
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- Female, Pregnancy, Humans, Social Class, Language, Magnetic Resonance Imaging, Brain diagnostic imaging, Brain physiology, Cognition physiology
- Abstract
Differences in socioeconomic status (SES) correlate both with differences in cognitive development and in brain structure. Associations between SES and brain measures such as cortical surface area and cortical thickness mediate differences in cognitive skills such as executive function and language. However, causal accounts that link SES, brain, and behavior are challenging because SES is a multidimensional construct: correlated environmental factors, such as family income and parental education, are only distal markers for proximal causal pathways. Moreover, the causal accounts themselves must span multiple levels of description, employ a developmental perspective, and integrate genetic effects on individual differences. Nevertheless, causal accounts have the potential to inform policy and guide interventions to reduce gaps in developmental outcomes. In this article, we review the range of empirical data to be integrated in causal accounts of developmental effects on the brain and cognition associated with variation in SES. We take the specific example of language development and evaluate the potential of a multiscale computational model of development, based on an artificial neural network, to support the construction of causal accounts. We show how, with bridging assumptions that link properties of network structure to magnetic resonance imaging (MRI) measures of brain structure, different sets of empirical data on SES effects can be connected. We use the model to contrast two possible causal pathways for environmental influences that are associated with SES: differences in prenatal brain development and differences in postnatal cognitive stimulation. We then use the model to explore the implications of each pathway for the potential to intervene to reduce gaps in developmental outcomes. The model points to the cumulative effects of social disadvantage on multiple pathways as the source of the poorest response to interventions. Overall, we highlight the importance of implemented models to test competing accounts of environmental influences on individual differences., (© 2022 Cognitive Science Society LLC.)
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- 2023
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196. Bidirectional associations between sleep problems and behavioural difficulties and health-related quality of life in adolescents: Evidence from the SCAMP longitudinal cohort study.
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Shen C, Mireku MO, Di Simplicio M, Dumontheil I, Thomas MSC, Röösli M, Elliott P, and Toledano MB
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Background: Sleep problems show associations with negative outcomes in both physical and mental health in adolescents, but the associations may be reciprocal. We aimed to assess bidirectional associations between sleep problems and mental health symptoms including behavioural difficulties (internalising and externalising difficulties) and low health-related quality of life (HRQoL)., Methods: A total of 6616 adolescents (52.4% females) across Greater London completed baseline assessments when they were aged 11-12 years, and 3803 of them (57.2% females) completed follow-up assessments at aged 13-15 years. Weekday and weekend sleep duration were derived from self-reported bedtime, sleep onset latency and wake time. Sleep disturbance was assessed using a standardized sleep disturbance scale. Internalising and externalising difficulties were assessed using subscales of the Strength and Difficulties Questionnaire. HRQoL was assessed using the KIDSCREEN-10 questionnaire. Cross-lagged structural equation modelling was used with multiple imputation to examine bidirectional associations between sleep problems and mental health symptoms., Results: Females had greater internalising difficulties, worse HRQoL and more sleep disturbance than males. Persistent insufficient weekday and weekend sleep, and sleep disturbance (i.e., at both baseline and follow-up) were associated with internalising and externalising difficulties and low HRQoL at follow-up (ORs ranged from 1.53 to 3.63). Persistent externalising difficulties and low HRQoL were also associated with insufficient weekend sleep and sleep disturbance at follow-up (ORs ranged from 1.68 to 4.25). Using continuous variables, we found bidirectional associations between weekday sleep duration and HRQoL, weekend sleep duration and externalising score, sleep quality and internalising score, and sleep quality and HRQoL. The association magnitudes were mostly similar in the two directions., Conclusions: Our study showed bidirectional associations between sleep problems and mental health symptoms during adolescence, indicating that early intervention and treatment on the first-occurring symptom may prevent the development of subsequent problems., Competing Interests: The authors have declared that they have no competing or potential conflicts of interest., (© 2022 The Authors. JCPP Advances published by John Wiley & Sons Ltdon behalf of Association for Child and Adolescent Mental Health.)
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- 2022
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197. Influences on cognitive outcomes in adult patients with gliomas: A systematic review.
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Kirkman MA, Hunn BHM, Thomas MSC, and Tolmie AK
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People with brain tumors, including those previously treated, are commonly affected by a range of neurocognitive impairments involving executive function, memory, attention, and social/emotional functioning. Several factors are postulated to underlie this relationship, but evidence relating to many of these factors is conflicting and does not fully explain the variation in cognitive outcomes seen in the literature and in clinical practice. To address this, we performed a systematic literature review to identify and describe the range of factors that can influence cognitive outcomes in adult patients with gliomas. A literature search was performed of Ovid MEDLINE, PsychINFO, and PsycTESTS from commencement until September 2021. Of 9,998 articles identified through the search strategy, and an additional 39 articles identified through other sources, 142 were included in our review. The results confirmed that multiple factors influence cognitive outcomes in patients with gliomas. The effects of tumor characteristics (including location) and treatments administered are some of the most studied variables but the evidence for these is conflicting, which may be the result of methodological and study population differences. Tumor location and laterality overall appear to influence cognitive outcomes, and detection of such an effect is contingent upon administration of appropriate cognitive tests. Surgery appears to have an overall initial deleterious effect on cognition with a recovery in most cases over several months. A large body of evidence supports the adverse effects of radiotherapy on cognition, but the role of chemotherapy is less clear. To contrast, baseline cognitive status appears to be a consistent factor that influences cognitive outcomes, with worse baseline cognition at diagnosis/pre-treatment correlated with worse long-term outcomes. Similarly, much evidence indicates that anti-epileptic drugs have a negative effect on cognition and genetics also appear to have a role. Evidence regarding the effect of age on cognitive outcomes in glioma patients is conflicting, and there is insufficient evidence for gender and fatigue. Cognitive reserve, brain reserve, socioeconomic status, and several other variables discussed in this review, and their influence on cognition and recovery, have not been well-studied in the context of gliomas and are areas for focus in future research., Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42017072976., (Copyright © 2022 Kirkman, Hunn, Thomas and Tolmie.)
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- 2022
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198. Modulatory effects of SES and multilinguistic experience on cognitive development: a longitudinal data analysis of multilingual and monolingual adolescents from the SCAMP cohort.
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Filippi R, Ceccolini A, Booth E, Shen C, Thomas MSC, Toledano MB, and Dumontheil I
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Previous research has shown that cognitive development is sensitive to socio-economic status (SES) and multilinguistic experiences. However, these effects are difficult to disentangle and SES may modulate the effects of multilingualism. The present study used data from a large cohort of pupils who took part in the Study of Cognition, Adolescents and Mobile Phones (SCAMP) at ages 11-12 (T1) and 13-15 years old (T2). Cognitive measures were derived from tasks of cognitive flexibility, verbal, spatial and visuo-spatial working memory, speech processing and non-verbal reasoning. Using SES information collected through questionnaires (school type, level of deprivation, parental education and occupation), the sample was clustered into high/medium/low SES groups. Comparisons focused on 517 monolingual and 329 multilingual pupils in the high/low SES groups. Having controlled for multiple comparisons, the results indicated a significant beneficial effect of bilingualism in measures of working memory, visuo-spatial processing and non-verbal reasoning. These effects were present in both high and low SES individuals and sustained at both times of development, with a particularly significant improvement of working memory abilities in low SES bilinguals at T2 as compared to monolingual peers. Theoretical and practical implications of these findings are considered and guidance for educators is discussed., Competing Interests: No potential conflict of interest was reported by the author(s)., (© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
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- 2022
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199. The developmental trajectories of spatial skills in middle childhood.
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Hodgkiss A, Gilligan-Lee KA, Thomas MSC, Tolmie AK, and Farran EK
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- Child, Humans, Male, Child Development, Spatial Navigation
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The multidimensional structure of spatial ability remains a debated issue. However, the developmental trajectories of spatial skills have yet to be investigated as a source of evidence within this debate. We tested the intrinsic versus extrinsic and static versus dynamic dimensions of the Uttal et al. (2013, Psychol. Bull., 139, 352) typology in relation to spatial development. Participants (N = 184) aged 6-11 completed spatial tasks chosen to measure these spatial dimensions. The results indicated that the developmental trajectories of intrinsic versus extrinsic skills differed significantly. Intrinsic skills improved more between 6 and 8 years, and 7 and 8 years, than extrinsic skills. Extrinsic skills increased more between 8 and 10 years than intrinsic skills. The trajectories of static versus dynamic skills did not differ significantly. The findings support the intrinsic versus extrinsic, but not the static versus dynamic dimension, of the Uttal et al. (2013, Psychol. Bull., 139, 352) typology., (© 2021 The Authors. British Journal of Developmental Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.)
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- 2021
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200. The role of context in verbal humor processing in autism.
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Purser HRM, Van Herwegen J, Ranzato E, and Thomas MSC
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- Child, Comprehension, Humans, Autism Spectrum Disorder, Autistic Disorder, Laughter
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Difficulties in processing humor have been associated with individuals with autism. The current study investigated whether humor comprehension and appreciation could be augmented in children with autism by providing contextual support suggesting that humor was to be expected. A verbally presented riddle task was used in which participants were assessed for their subjective ratings and comprehension of the materials. They were also filmed to record any smiling or laughing. Both riddles and control stimuli were presented with supporting verbal context and also without it. The results showed that (a) the greater subjective appreciation of riddles than of control stimuli was dependent on the provision of context for the participants with autism and that (b) context statistically equated these ratings of riddles between participants with autism and matched typically developing controls. However, context had no effect on comprehension or affective response. The results of the current study demonstrate that children with autism are, even in the most conservative interpretation, able to use verbal context to recognize verbal humor. This lays the foundation of possible interventions based on training sensitivity to context., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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