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Aim. Selection of optimal dosage regimen, length of treatment course (frequency of administration), safety, tolerance and clinical effectiveness evaluation of the medical preparation fortepren in patients with chronical recurrent herpes virus infection of genital localization. Materials and methods. The medical product of antiviral and immune modulating effect - fortepren (sodium polyprenyl phosphate) as a 4 mg/ml solution for injections combined with the base course of acyclic nucleoside acyclovir, 400 mg tablets, held studies. 40 male and female patients participated in the study. After a 10-day acyclovir course (400 mg x 3 times a day) for removing the acute phase, 4 groups of 10 individuals were formed: 1 - 5 ml (20 mg) of fortepren i/m once at day 13+2 after the start of the study after the completion of the treatment of the acute phase of the disease; 2 - 5 ml (20 mg) fortepren i/m 3 times at an interval of 21 days; 3 - 2 ml (8 mg) fortepren i/m 3 times at an interval of 21 days; 4 (control) - 5 ml of placebo i/m at remission stage 3 times at an interval of 21 days. Increase of the duration of inter-recurrence period, decrease of the severity of the recurrences, state of skin and mucous damage elements, improvements of immunologic parameters were considered during effectiveness evaluation. Results. Significant differences in the frequency of recurrences of genital herpes were shown for 3 months of observation in experimental and control groups. A significant reduction of genital herpes recurrence frequency from 3.52+0.09 (before treatment) to 2.89+0.08 (after treatment) was noted in patients of group 3 (p