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763 results on '"Valdés Olmos, Renato"'

153. Additional value of (18)F-FDG PET/CT response evaluation in axillary nodes during neoadjuvant therapy for triple-negative and HER2-positive breast cancer

Author

van Ramshorst, Mette S, Teixeira, Suzana C, Koolen, Bas B, Pengel, Kenneth E, Gilhuijs, Kenneth G, Wesseling, Jelle, Rodenhuis, Sjoerd, Valdés Olmos, Renato A, Rutgers, Emiel J, Vogel, Wouter V, Sonke, Gabe S, Vrancken Peeters, Marie-Jeanne T, van Ramshorst, Mette S, Teixeira, Suzana C, Koolen, Bas B, Pengel, Kenneth E, Gilhuijs, Kenneth G, Wesseling, Jelle, Rodenhuis, Sjoerd, Valdés Olmos, Renato A, Rutgers, Emiel J, Vogel, Wouter V, Sonke, Gabe S, and Vrancken Peeters, Marie-Jeanne T

Published
2017

154. Monitoring tumor response to neoadjuvant chemotherapy using MRI and 18F-FDG PET/CT in breast cancer subtypes

Author

Schmitz, Alexander M Th, Teixeira, Suzana C, Pengel, Kenneth E, Loo, Claudette E, Vogel, Wouter V, Wesseling, Jelle, Rutgers, Emiel J Th, Valdés Olmos, Renato A, Sonke, Gabe S, Rodenhuis, Sjoerd, Vrancken Peeters, Marie Jeanne T F D, Gilhuijs, Kenneth G A, Schmitz, Alexander M Th, Teixeira, Suzana C, Pengel, Kenneth E, Loo, Claudette E, Vogel, Wouter V, Wesseling, Jelle, Rutgers, Emiel J Th, Valdés Olmos, Renato A, Sonke, Gabe S, Rodenhuis, Sjoerd, Vrancken Peeters, Marie Jeanne T F D, and Gilhuijs, Kenneth G A

Published
2017

155. Additional value of (18)F-FDG PET/CT response evaluation in axillary nodes during neoadjuvant therapy for triple-negative and HER2-positive breast cancer

Author

Beeldverwerking ISI, Cancer, Arts-assistenten Radiotherapie, van Ramshorst, Mette S, Teixeira, Suzana C, Koolen, Bas B, Pengel, Kenneth E, Gilhuijs, Kenneth G, Wesseling, Jelle, Rodenhuis, Sjoerd, Valdés Olmos, Renato A, Rutgers, Emiel J, Vogel, Wouter V, Sonke, Gabe S, Vrancken Peeters, Marie-Jeanne T, Beeldverwerking ISI, Cancer, Arts-assistenten Radiotherapie, van Ramshorst, Mette S, Teixeira, Suzana C, Koolen, Bas B, Pengel, Kenneth E, Gilhuijs, Kenneth G, Wesseling, Jelle, Rodenhuis, Sjoerd, Valdés Olmos, Renato A, Rutgers, Emiel J, Vogel, Wouter V, Sonke, Gabe S, and Vrancken Peeters, Marie-Jeanne T

Published
2017

156. Monitoring tumor response to neoadjuvant chemotherapy using MRI & 18F-FDG PET/CT in breast cancer subtypes

Author

Beeldverwerking ISI, Arts-assistenten Radiotherapie, Cancer, Schmitz, Alexander M Th, Teixeira, Suzana C, Pengel, Kenneth E, Loo, Claudette E, Vogel, Wouter V, Wesseling, Jelle, Rutgers, Emiel J Th, Valdés Olmos, Renato A, Sonke, Gabe S, Rodenhuis, Sjoerd, Vrancken Peeters, Marie Jeanne T F D, Gilhuijs, Kenneth G A, Beeldverwerking ISI, Arts-assistenten Radiotherapie, Cancer, Schmitz, Alexander M Th, Teixeira, Suzana C, Pengel, Kenneth E, Loo, Claudette E, Vogel, Wouter V, Wesseling, Jelle, Rutgers, Emiel J Th, Valdés Olmos, Renato A, Sonke, Gabe S, Rodenhuis, Sjoerd, Vrancken Peeters, Marie Jeanne T F D, and Gilhuijs, Kenneth G A

Published
2017

159. Advances in radioguided surgery in oncology

Author

Valdés Olmos, Renato A., primary, Vidal-Sicart, Sergi, additional, Manca, Gianpiero, additional, Mariani, Giuliano, additional, León-Ramírez, Luisa F., additional, Rubello, Domenico, additional, and Giammarile, Francesco, additional

Published
2017
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160. Evaluation of Dual-Timepoint 18F-FDG PET/CT Imaging for Lymph Node Staging in Vulvar Cancer

Author

Collarino, Angela, primary, Garganese, Giorgia, additional, Valdés Olmos, Renato A., additional, Stefanelli, Antonella, additional, Perotti, Germano, additional, Mirk, Paoletta, additional, Fragomeni, Simona M., additional, Ieria, Francesco P., additional, Scambia, Giovanni, additional, Giordano, Alessandro, additional, and Rufini, Vittoria, additional

Published
2017
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161. Additional value of 18F-FDG PET/CT response evaluation in axillary nodes during neoadjuvant therapy for triple-negative and HER2-positive breast cancer

Author

van Ramshorst, Mette S., primary, Teixeira, Suzana C., additional, Koolen, Bas B., additional, Pengel, Kenneth E., additional, Gilhuijs, Kenneth G., additional, Wesseling, Jelle, additional, Rodenhuis, Sjoerd, additional, Valdés Olmos, Renato A., additional, Rutgers, Emiel J., additional, Vogel, Wouter V., additional, Sonke, Gabe S., additional, and Vrancken Peeters, Marie-Jeanne T., additional

Published
2017
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162. Monitoring tumor response to neoadjuvant chemotherapy using MRI and 18F-FDG PET/CT in breast cancer subtypes

Author

Schmitz, Alexander M. Th., primary, Teixeira, Suzana C., additional, Pengel, Kenneth E., additional, Loo, Claudette E., additional, Vogel, Wouter V., additional, Wesseling, Jelle, additional, Rutgers, Emiel J. Th., additional, Valdés Olmos, Renato A., additional, Sonke, Gabe S., additional, Rodenhuis, Sjoerd, additional, Vrancken Peeters, Marie Jeanne T. F. D., additional, and Gilhuijs, Kenneth G. A., additional

Published
2017
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167. Effectiveness of an (18)F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy : The RELAPS multicenter randomized trial

Author

de Bree, Remco, van der Putten, Lisa, van Tinteren, Harm, Wedman, Jan, Oyen, Wim J G, Janssen, LM, van den Brekel, Michiel W M, Comans, Emile F I, Pruim, Jan, Takes, Robert P, Hobbelink, MGG, Valdés Olmos, Renato, van der Laan, Bernard F A M, Boers, Maarten, Hoekstra, Otto S, Leemans, C René, de Bree, Remco, van der Putten, Lisa, van Tinteren, Harm, Wedman, Jan, Oyen, Wim J G, Janssen, LM, van den Brekel, Michiel W M, Comans, Emile F I, Pruim, Jan, Takes, Robert P, Hobbelink, MGG, Valdés Olmos, Renato, van der Laan, Bernard F A M, Boers, Maarten, Hoekstra, Otto S, and Leemans, C René

Published
2016

168. Effectiveness of an (18)F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy: The RELAPS multicenter randomized trial

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS KNO, Other research (not in main researchprogram), Arts-assistenten Nucleaire Geneesk., de Bree, Remco, van der Putten, Lisa, van Tinteren, Harm, Wedman, Jan, Oyen, Wim J G, Janssen, LM, van den Brekel, Michiel W M, Comans, Emile F I, Pruim, Jan, Takes, Robert P, Hobbelink, MGG, Valdés Olmos, Renato, van der Laan, Bernard F A M, Boers, Maarten, Hoekstra, Otto S, Leemans, C René, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS KNO, Other research (not in main researchprogram), Arts-assistenten Nucleaire Geneesk., de Bree, Remco, van der Putten, Lisa, van Tinteren, Harm, Wedman, Jan, Oyen, Wim J G, Janssen, LM, van den Brekel, Michiel W M, Comans, Emile F I, Pruim, Jan, Takes, Robert P, Hobbelink, MGG, Valdés Olmos, Renato, van der Laan, Bernard F A M, Boers, Maarten, Hoekstra, Otto S, and Leemans, C René

Published
2016

169. Combined use of ¹⁸F-FDG PET/CT and MRI for response monitoring of breast cancer during neoadjuvant chemotherapy

Author

Pengel, Kenneth E., Koolen, Bas B., Loo, Claudette E., Vogel, Wouter V., Wesseling, Jelle, Lips, Esther H., Rutgers, Emiel J. Th, Valdés Olmos, Renato A., Vrancken Peeters, Marie Jeanne T. F. D., Rodenhuis, Sjoerd, Gilhuijs, Kenneth G. A., and Other departments

Abstract

To explore the potential complementary value of PET/CT and dynamic contrast-enhanced MRI in predicting pathological response to neoadjuvant chemotherapy (NAC) of breast cancer and the dependency on breast cancer subtype. We performed (18)F-FDG PET/CT and MRI examinations before and during NAC. The imaging features evaluated on both examinations included baseline and changes in (18)F-FDG maximum standardized uptake value (SUVmax) on PET/CT, and tumour morphology and contrast uptake kinetics on MRI. The outcome measure was a (near) pathological complete response ((near-)pCR) after surgery. Receiver operating characteristic curves with area under the curve (AUC) were used to evaluate the relationships between patient, tumour and imaging characteristics and tumour responses. Of 93 patients, 43 achieved a (near-)pCR. The responses varied among the different breast cancer subtypes. On univariate analysis the following variables were significantly associated with (near-)pCR: age (p = 0.033), breast cancer subtype (p

Published
2014

171. Evaluation of a Hanging-Breast PET System for Primary Tumor Visualization in Patients With Stage I–III Breast Cancer: Comparison With Standard PET/CT

Author

Teixeira, Suzana C., primary, Rebolleda, José Ferrér, additional, Koolen, Bas B., additional, Wesseling, Jelle, additional, Jurado, Raúl Sánchez, additional, Stokkel, Marcel P. M., additional, del Puig Cózar Santiago, María, additional, van der Noort, Vincent, additional, Rutgers, Emiel J. Th., additional, and Valdés Olmos, Renato A., additional

Published
2016
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174. Additional Prone 18F-FDG PET/CT Acquisition to Improve the Visualization of the Primary Tumor and Regional Lymph Node Metastases in Stage II/III Breast Cancer

Author

Teixeira, Suzana Cipriano, primary, Koolen, Bas B., additional, Vogel, Wouter V., additional, Wesseling, Jelle, additional, Stokkel, Marcel P. M., additional, Vrancken Peeters, Marie-Jeanne T. F. D., additional, van der Noort, Vincent, additional, Rutgers, Emiel J. Th., additional, and Valdés Olmos, Renato A., additional

Published
2016
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178. Effectiveness of an 18F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy: The RELAPS multicenter randomized trial

Author

de Bree, Remco, primary, van der Putten, Lisa, additional, van Tinteren, Harm, additional, Wedman, Jan, additional, Oyen, Wim J.G., additional, Janssen, Luuk M., additional, van den Brekel, Michiel W.M., additional, Comans, Emile F.I., additional, Pruim, Jan, additional, Takes, Robert P., additional, Hobbelink, Monique G.G., additional, Valdés Olmos, Renato, additional, van der Laan, Bernard F.A.M., additional, Boers, Maarten, additional, Hoekstra, Otto S., additional, and Leemans, C. René, additional

Published
2016
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180. First clinical experience with a dedicated PET for hanging breast molecular imaging

Author

Koolen, Bas, Aukema, T. S., González Martínez, Antonio Javier, Vogel, W., Caballero Ontanaya, Luis, Vrancken Peeters, Marie-Jeanne, Vroonland, Colinda, Rutgers, Emiel, Benlloch Baviera, Jose María, and Valdés Olmos, Renato

Subjects
Adult, Breast neoplasm, PET/CT, Biopsy, Breast Neoplasms, Pilot Projects, Equipment Design, Middle Aged, Molecular Imaging, Breast cancer, Breast PET, Fluorodeoxyglucose F18, Positron-Emission Tomography, Dedicated PET, Humans, Female, Radiopharmaceuticals, Tomography, X-Ray Computed, Positron Emission Tomography, Aged, Mammography
Abstract

[EN] Aim. Recently, a high-resolution dedicated PET system for hanging breast imaging (MAMMI PET) has been developed to improve primary tumor detection and characterization. The aim of this pilot study was to assess its feasibility for tumor detection and FDG uptake measurements in patients with stage II and III breast cancer. Methods. Thirty-two patients with invasive breast cancer (26 ductal, 4 lobular, 2 other), prior to and/or during neoadjuvant chemotherapy, underwent both conventional PET/CT and MAMMI PET in prone position with hanging breasts. Conventional PET/CT and MAMMI PET were performed 60 +/- 10 min and 110 +/- 10 min after injection of 180-240 MBq of FDG, respectively. Primary tumor detection was assessed and FDG uptake, expressed as maximum standardized uptake value (SUVmax), was calculated. Results. Both MAMMI PET and conventional PET/CT visualized the primary tumor in 31 patients (97%). The mean distance from the tumor to the pectoral muscle was 26.4mm (smallest distance 3.3mm). Agreement in FDG uptake between PET/CT and MAMMI PET was high (r=0.86, 95% CI 0.69-0.94). However, SUVmax as assessed with MAMMI PET was consistently higher than with PET/CT in all patients with an average ratio of 2.7. Conclusion. The dedicated high-resolution breast PET with hanging breast technique is able to visualize approximately all breast tumors in stage II and III breast cancer patients, including tumors in the vicinity of the thoracic wall. This may enable its sequential use in the assessment of response in breast cancer patients receiving neoadjuvant systemic therapy, although SUVmax. values are not directly comparable to standard PET/CT., This study was an EC funded project: MAMMI, proposal 037555

Published
2013

181. Early assessment of axillary response with ¹⁸F-FDG PET/CT during neoadjuvant chemotherapy in stage II-III breast cancer: implications for surgical management of the axilla

Author

Koolen, Bas B., Valdés Olmos, Renato A., Wesseling, Jelle, Vogel, Wouter V., Vincent, Andrew D., Gilhuijs, Kenneth G. A., Rodenhuis, Sjoerd, Rutgers, Emiel J. Th, Vrancken Peeters, Marie-Jeanne T. F. D., and Other departments

Abstract

If all initially node-positive patients undergo axillary lymph node dissection (ALND) after neoadjuvant chemotherapy (NAC), overtreatment may occur in patients with complete response. Positron emission tomography-computed tomography (PET/CT) during NAC may predict axillary response and select patients appropriate for less invasive treatment after NAC. We evaluated the value of sequential (18)F fluorodeoxyglucose (FDG) PET/CTs during NAC for axillary response monitoring in stage II-III breast cancer. A total of 219 PET/CTs were performed in 80 patients with cytology-proven, node-positive disease at baseline (PET/CT1, n = 80) and twice during NAC (PET/CT2 n = 62, PET/CT3, n = 77). The relative changes in maximum standardized uptake value (SUVmax) of axillary nodes were examined for their ability to assess pathological response. All patients underwent ALND after chemotherapy, and complete axillary response (pCR), defined as absence of isolated tumor cells and of micro- and macrometastases, served as the reference standard. A total of 32 (40 %) patients experienced axillary pCR. The relative decrease in SUVmax was significantly higher in patients with pCR than in those without, both on PET/CT2 (p < 0.001) and PET/CT3 (p = 0.025). The area under the receiver operating characteristic curve values for PET/CT2 and PET/CT3 were 0.80 (95 % confidence interval 0.68-0.92) and 0.65 (95 % confidence interval 0.52-0.79), respectively. A relative decrease of ≥60 % on PET/CT2 had an excellent specificity (35 of 37, 95 %), a high positive predictive value (12 of 14, 86 %), and a sensitivity of 48 %-that is, it accurately identified histologic pCR in 12 of 25 patients with disease that responded to therapy. (18)F-FDG PET/CT early during NAC is useful for axillary response monitoring in cytology-proven node-positive breast cancer because it identifies pathological response, thus permitting ALND to be spared

Published
2013

182. Sentinel Node Mapping for Breast Cancer: Current Situation

Author

Vidal-Sicart, Sergi and Valdés Olmos, Renato

Subjects
Article Subject
Abstract

Axillary node status is a major prognostic factor in early-stage disease. Traditional staging needs levels I and II axillary lymph node dissection. Axillary involvement is found in 10%–30% of patients with T1 (

Published
2012
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186. Multimodal Surgical Guidance during Sentinel Node Biopsy for Melanoma: Combined Gamma Tracing and Fluorescence Imaging of the Sentinel Node through Use of the Hybrid Tracer Indocyanine Green–99mTc-Nanocolloid

Author

van den Berg, Nynke S., primary, Brouwer, Oscar R., additional, Schaafsma, Boudewijn E., additional, Mathéron, Hanna M., additional, Klop, W. Martin C., additional, Balm, Alfons J. M., additional, van Tinteren, Harm, additional, Nieweg, Omgo E., additional, van Leeuwen, Fijs W. B., additional, and Valdés Olmos, Renato A., additional

Published
2015
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189. Abstract P1-02-03: The effect on short–term progression free survival of the detection of ≥4 FDG-avid nodes or occult N3–disease in breast cancer patients with PET/CT

Author

Teixeira, Suzana C, primary, Koolen, Bas B, additional, Elkhuizen, Paula HM, additional, van der Noort, Vincent, additional, Vrancken-Peeters, Marie-Jeanne, additional, Stokkel, Marcel P, additional, Rutgers, Emiel J Th, additional, and Valdés-Olmos, Renato A, additional

Published
2015
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190. Optimisation of Fluorescence Guidance During Robot-assisted Laparoscopic Sentinel Node Biopsy for Prostate Cancer

Author

KleinJan, Gijs H., primary, van den Berg, Nynke S., additional, Brouwer, Oscar R., additional, de Jong, Jeroen, additional, Acar, Cenk, additional, Wit, Esther M., additional, Vegt, Erik, additional, van der Noort, Vincent, additional, Valdés Olmos, Renato A., additional, van Leeuwen, Fijs W.B., additional, and van der Poel, Henk G., additional

Published
2014
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191. Feasibility of Intraoperative Navigation to the Sentinel Node in the Groin Using Preoperatively Acquired Single Photon Emission Computerized Tomography Data: Transferring Functional Imaging to the Operating Room

Author

Brouwer, Oscar R., primary, van den Berg, Nynke S., additional, Mathéron, Hanna M., additional, Wendler, Thomas, additional, van der Poel, Henk G., additional, Horenblas, Simon, additional, Valdés Olmos, Renato A., additional, and van Leeuwen, Fijs W.B., additional

Published
2014
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195. Clinical implications of sentinel nodes outside the axilla and internal mammary chain in patients with breast cancer

Author

van Rijk, Maartje C., Tanis, Pieter J., Nieweg, Omgo E., Valdés Olmos, Renato A., Rutgers, Emiel J. Th, Hoefnagel, Cornelis A., Kroon, Bin B. R., AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Surgery

Abstract

PURPOSE: The aim of this study was to determine the incidence, location, surgical identification rate, tumor status, and clinical implications of sentinel nodes outside the axilla and internal mammary chain. PATIENTS AND METHODS: In 785 breast cancer patients, pre-operative lymphoscintigraphy was performed after intratumoral injection of 116 MBq 99mTc-labeled nanocolloid (0.2 ml; 3.1 mCi). Sentinel nodes were pursued using a gamma-ray detection probe and vital blue dye. RESULTS: Lymphoscintigraphy visualized sentinel nodes outside the axilla and internal mammary chain in 91 of the 785 patients (12%). Sentinel nodes (106) were identified in 80 patients. These nodes were found in the following locations: 50 in the breast, 31 in the infraclavicular fossa, 19 between the pectoral muscles, and 6 within the supraclavicular bed. Eighteen nodes contained a metastasis (17%) and were removed from 16 patients. The treatment strategy was adjusted in 12 of them with the addition of adjuvant local or systemic therapy. Two additional patients with an unusually situated tumor-negative sentinel node were spared an axillary node dissection that would otherwise have been performed. CONCLUSION: Unusually situated sentinel nodes were visualized in 12% of the patients. The treatment was adjusted in 18% of patients in whom these nodes were identified

Published
2006

196. Additional value of 18F-FDG PET/CT response evaluation in axillary nodes during neoadjuvant therapy for triple-negative and HER2-positive breast cancer.

Author

van Ramshorst, Mette S., Teixeira, Suzana C., Koolen, Bas B., Pengel, Kenneth E., Gilhuijs, Kenneth G., Wesseling, Jelle, Rodenhuis, Sjoerd, Olmos, Renato A. Valdés, Rutgers, Emiel J., Vogel, Wouter V., Sonke, Gabe S., Peeters, Marie-Jeanne T. Vrancken, Valdés Olmos, Renato A, and Vrancken Peeters, Marie-Jeanne T

Published
2017
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197. Monitoring tumor response to neoadjuvant chemotherapy using MRI and 18F-FDG PET/CT in breast cancer subtypes.

Author

Schmitz, Alexander M. Th., Teixeira, Suzana C., Pengel, Kenneth E., Loo, Claudette E., Vogel, Wouter V., Wesseling, Jelle, Rutgers, Emiel J. Th., Valdés Olmos, Renato A., Sonke, Gabe S., Rodenhuis, Sjoerd, Vrancken Peeters, Marie Jeanne T. F. D., and Gilhuijs, Kenneth G. A.

Subjects
BREAST cancer diagnosis, CANCER chemotherapy, MAGNETIC resonance mammography, BREAST biopsy, COHORT analysis
Abstract

Purpose: To explore guidelines on the use of MRI and PET/CT monitoring primary tumor response to neoadjuvant chemotherapy (NAC), taking breast cancer subtype into account. Materials and methods: In this prospective cohort study, 188 women were included with stages II and III breast cancer. MRI and 18F-FDG-PET/CT were acquired before and during NAC. Baseline pathology was assessed from tumor biopsy. Tumors were stratified into HER2-positive, ER-positive/HER2-negative (ER-positive), and ER-negative/PR-negative/HER2-negative (triple-negative) subtypes, and treated according to subtype. Primary endpoint was pathological complete response (pCRmic) defined as no or only small numbers of scattered invasive tumor cells. We evaluated imaging scenarios using MRI only, PET/CT only, and combinations. Results: pCRmic was found in 35/46 (76.1%) of HER2-positive, 11/87 (12.6%) of ER-positive, and 31/55 (56.4%) of triple-negative tumors. For HER2-positive tumors, MRI yielded the strongest predictor (AUC: 0.735; sensitivity 36.2%), outperforming PET/CT (AUC: 0.543; p = 0.04), and with comparable results to combined imaging (AUC: 0.708; p = 0.213). In ER-positive tumors, the combination of MRI and PET/CT was slightly superior (AUC: 0.818; sensitivity 55.8%) over MRI alone (AUC: 0.742; p = 0.117) and PET/CT alone (AUC: 0.791). However, even though relatively large numbers of ER-positive tumor patients were included, no significant differences were yet found. For triple-negative tumors, MRI (AUC: 0.855; sensitivity 45.4%), PET/CT (AUC: 0.844; p = 0.220) and combined imaging (AUC: 0.868; p = 0.213) yielded comparable results. Conclusions: For HER2-positive tumors, MRI shows significant advantage over PET/CT. For triple-negative tumors, comparable results were seen for MRI, PET/CT and combined imaging. For ER-positive tumors, combining MRI with PET/CT may result in optimal response monitoring, although not yet significantly. [ABSTRACT FROM AUTHOR]

Published
2017
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198. Contribution of SPECT/CT for sentinel node localization in patients with ipsilateral breast cancer relapse.

Author

Borrelli, Pablo, Donswijk, Maarten, Stokkel, Marcel, Teixeira, Suzana, Tinteren, Harm, Rutgers, Emiel, and Valdés Olmos, Renato

Subjects
SENTINEL lymph nodes, BIOPSY, BREAST cancer patients, CANCER relapse, AXILLARY lymph node dissection
Abstract

Background: In recent years repeat sentinel node (SN) biopsy has been proven to be feasible in local breast cancer recurrence (LBCR). However, in these patients SNs outside the ipsilateral axilla are frequently observed. This study evaluates the contribution of SPECT/CT for SN localization and surgical adjustment in LBCR patients. Methods: SN biopsy was performed in 122 LBCR patients (median age 60.5 years, range 24-87), enrolled from August 2006 to July 2015. Median disease-free time lapse was 109.5 months (range 9-365). Axillary lymph node dissection (ALND) had previously been performed in 55 patients, SN biopsy in 44, both techniques in 13 and fine-needle aspiration in 10. Primary breast cancer treatment included radiotherapy in 104 patients (85.3 %) and chemotherapy in 40 (32.8 %). Preoperative lymphatic mapping, using planar scintigraphy (PS) and SPECT/CT included report of SN location according to lymph node territory. In case of a territorial PS-SPECT/CT mismatch, surgery was adjusted according to SPECT/CT findings. Results: SPECT/CT SN visualization rate was higher than PS (53.3 % vs. 43.4 %, p n.s.) with, in total, 19 additional SN (118 vs. 99, p n.s.). PS-SPECT/CT territory mismatch, found in 60 % (39/65) of patients with SN visualization, led to surgical adjustment in 21.3 % (26/122) of patients. The SN procedure was finally performed in 104 patients resulting in a 65.7 % surgical retrieval rate with a total of 132 removed SNs (1.86/patient). SN metastases were found in 17/71 patients (23.9 %), in 16 of them (94 %) in ipsilateral basins outside the axilla or in the contralateral axilla. Conclusion: Using SPECT/CT there is a trend to visualize more SNs in LBCR, providing at the same time important anatomical information to adjust intraoperative SN procedures. The addition of SPECT/CT to the standard imaging protocol may lead to better staging mainly in patients presenting drainage outside the ipsilateral axilla. [ABSTRACT FROM AUTHOR]

Published
2017
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