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151. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Amino acids

Author

van Goudoever, Johannes B., Carnielli, Virgilio, Darmaun, Dominique, de Pipaon, Miguel Sainz, Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Christian, Molgaard, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, Weihui, Yan, van Goudoever, Johannes B., Carnielli, Virgilio, Darmaun, Dominique, de Pipaon, Miguel Sainz, Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Christian, Molgaard, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, and Weihui, Yan

Abstract

Part: B

Published
2018
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152. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Complications

Author

Hartman, Corina, Shamir, Raanan, Simchowitz, Venetia, Lohner, Szimonetta, Cai, Wei, Decsi, Tamas, Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, Weihui, Yan, Hartman, Corina, Shamir, Raanan, Simchowitz, Venetia, Lohner, Szimonetta, Cai, Wei, Decsi, Tamas, Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, and Weihui, Yan

Abstract

Part: B

Published
2018
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153. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Fluid and electrolytes

Author

Jochum, F., Moltu, S. J., Senterre, T., Nomayo, A., Goulet, O., Iacobelli, S., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, Weihui, Yan, Jochum, F., Moltu, S. J., Senterre, T., Nomayo, A., Goulet, O., Iacobelli, S., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, and Weihui, Yan

Abstract

Part: B

Published
2018
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154. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Lipids

Author

Lapillonne, Alexandre, Mis, Natasa Fidler, Goulet, Olivier, van den Akker, Chris H. P., Wu, Jennifer, Koletzko, Berthold, Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Ksiazyk, Janusz, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, Weihui, Yan, Lapillonne, Alexandre, Mis, Natasa Fidler, Goulet, Olivier, van den Akker, Chris H. P., Wu, Jennifer, Koletzko, Berthold, Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Ksiazyk, Janusz, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, and Weihui, Yan

Abstract

Part: B

Published
2018
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155. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Home parenteral nutrition

Author

Hill, Susan, Ksiazyk, Janusz, Prell, Christine, Tabbers, Merit, Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, Weihui, Yan, Hill, Susan, Ksiazyk, Janusz, Prell, Christine, Tabbers, Merit, Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, and Weihui, Yan

Abstract

Part: B

Published
2018
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156. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Venous access

Author

Kolacek, S., Puntis, J. W. L., Hojsak, I., Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, Weihui, Yan, Kolacek, S., Puntis, J. W. L., Hojsak, I., Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, and Weihui, Yan

Abstract

Part: B

Published
2018
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157. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Organisational aspects

Author

Puntis, J. W. L., Hojsak, I., Ksiazyk, J., Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, Weihui, Yan, Puntis, J. W. L., Hojsak, I., Ksiazyk, J., Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, and Weihui, Yan

Abstract

Part: B

Published
2018
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158. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Carbohydrates

Author

Mesotten, D., Joosten, K., van Kempen, A., Verbruggen, S., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, Weihui, Yan, Mesotten, D., Joosten, K., van Kempen, A., Verbruggen, S., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, and Weihui, Yan

Abstract

Part: B

Published
2018
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159. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Standard versus individualized parenteral nutrition

Author

Riskin, Arieh, Picaud, Jean-Charles, Shamir, Raanan, Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Saenz De Pipaon, Miguel, Senterre, Thibault, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, Weihui, Yan, Riskin, Arieh, Picaud, Jean-Charles, Shamir, Raanan, Braegger, Christian, Bronsky, Jiri, Wei, Cai, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Tamas, Decsi, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Szimonetta, Lohner, Mesotten, Dieter, Krisztina, Mihalyi, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Saenz De Pipaon, Miguel, Senterre, Thibault, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Jiang, Wu, and Weihui, Yan

Abstract

Part B

Published
2018
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160. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition

Author

Mihatsch, Walter A., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Desci, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Mis, Natasa Fidler, Franz, Axel, Goulet, Olivier, Hartman, Corina, Susan, Hill, Hojsak, Iva, Lacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz de Pipaon, Miguel, Senterre, Thibault, Shamir, Ranaan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., van den Akker, Chris H. B., van Goudoever, Johannes B., van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, Yan, Weihui, Mihatsch, Walter A., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Desci, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Mis, Natasa Fidler, Franz, Axel, Goulet, Olivier, Hartman, Corina, Susan, Hill, Hojsak, Iva, Lacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz de Pipaon, Miguel, Senterre, Thibault, Shamir, Ranaan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., van den Akker, Chris H. B., van Goudoever, Johannes B., van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, and Yan, Weihui

Abstract

Part: B

Published
2018
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161. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition

Author

Mihatsch, Walter A, Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Desci, Tamas, Domellof, Magnus, Embleton, Nicholas, Fewtrell, Mary, Mis, Natasa Fidler, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Lacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mimouni, Francis, Mølgaard, Christian, Moltu, Sissel J, Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz de Pipaon, Miguel, Senterre, Thibault, Shamir, Ranaan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M, van den Akker, Chris H B, van Goudoever, Johannes B, van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, Yan, Weihui, Mihatsch, Walter A, Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Desci, Tamas, Domellof, Magnus, Embleton, Nicholas, Fewtrell, Mary, Mis, Natasa Fidler, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Lacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihalyi, Krisztina, Mimouni, Francis, Mølgaard, Christian, Moltu, Sissel J, Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz de Pipaon, Miguel, Senterre, Thibault, Shamir, Ranaan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M, van den Akker, Chris H B, van Goudoever, Johannes B, van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, and Yan, Weihui

Published
2018

162. Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial

Author

van Puffelen, Esther, primary, Polinder, Suzanne, additional, Vanhorebeek, Ilse, additional, Wouters, Pieter Jozef, additional, Bossche, Niek, additional, Peers, Guido, additional, Verstraete, Sören, additional, Joosten, Koen Felix Maria, additional, Van den Berghe, Greet, additional, Verbruggen, Sascha Cornelis Antonius Theodorus, additional, and Mesotten, Dieter, additional

Published
2018
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163. Priorities for Nutrition Research in Pediatric Critical Care.

Author

Tume, Lyvonne N., Valla, Frédéric V., Floh, Alejandro A., Goday, Praveen, Jotterand Chaparro, Corinne, Larsen, Bodil, Lee, Jan Hau, Moreno, Yara M. F., Pathan, Nazima, Verbruggen, Sascha, and Mehta, Nilesh M.

Subjects
CHILD nutrition, CRITICAL care medicine, LIKERT scale, DIET therapy, PARENTERAL feeding, RESEARCH, INTENSIVE care units, NUTRITIONAL requirements, PEDIATRICS, CATASTROPHIC illness, NUTRITION disorders in children, DELPHI method
Abstract

Background: Widespread variation exists in pediatric critical care nutrition practices, largely because of the scarcity of evidence to guide best practice recommendations.Objective: The objective of this paper was to develop a list of topics to be prioritized for nutrition research in pediatric critical care in the next 10 years.Methods: A modified 3-round Delphi process was undertaken by a newly established multidisciplinary group comprising 11 international researchers in the field of pediatric critical care nutrition. Items were ranked on a 5-point Likert scale.Results: Forty-five research topics (with a mean priority score >3(0-5) were identified within the following 10 domains: the pathophysiology and impact of malnutrition in critical illness; nutrition assessment: nutrition risk assessment and biomarkers; accurate assessment of energy requirements in all phases of critical illness; the role of protein intake; the role of pharmaco-nutrition; effective and safe delivery of enteral nutrition; enteral feeding intolerance: assessment and management; the role of parenteral nutrition; the impact of nutrition status and nutrition therapies on long-term patient outcomes; and nutrition therapies for specific populations. Ten top research topics (that received a mean score >4(0-5) were identified as the highest priority for research.Conclusions: This paper has identified important consensus-derived priorities for clinical research in pediatric critical care nutrition. Future studies should determine topics that are a priority for patients and parents. Research funding should target these priority areas and promote an international collaborative approach to research in this field, with a focus on improving relevant patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2019
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167. Correction: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children—a systematic review and meta-analysis.

Author

Brossier, David W., Tume, Lyvonne N., Briant, Anais R., Jotterand Chaparro, Corinne, Moullet, Clémence, Rooze, Shancy, Verbruggen, Sascha C. A. T., Marino, Luise V., Alsohime, Fahad, Beldjilali, Sophie, Chiusolo, Fabrizio, Costa, Leonardo, Didier, Capucine, Ilia, Stavroula, Joram, Nyandat L., Kneyber, Martin C. J., Kühlwein, Eva, Lopez, Jorge, López-Herce, Jesus, and Mayberry, Huw F.

Subjects
CRITICALLY ill children, FLUID therapy
Abstract

Graph Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Correction: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children - a systematic review and meta-analysis Correction: Intensive Care Medicine https://doi.org/10.1007/s00134-022-06882-z An incorrect Fig. [Extracted from the article]

Published
2023
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168. Intravenous maintenance fluid therapy in acutely and critically ill children: state of the evidence

Author

Brossier, David W, Goyer, Isabelle, Verbruggen, Sascha C A T, Jotterand Chaparro, Corinne, Rooze, Shancy, Marino, Luise V, Schlapbach, Luregn J, Tume, Lyvonne N, and Valla, Frederic V

Abstract

Intravenous maintenance fluid therapy (IV-MFT) is one of the most prescribed, yet one of the least studied, interventions in paediatric acute and critical care settings. IV-MFT is not typically treated in the same way as drugs with specific indications, contraindications, compositions, and associated adverse effects. In the last decade, societies in both paediatric and adult medicine have issued evidence-based practice guidelines for the use of intravenous fluids in clinical practice. The main objective of this Viewpoint is to summarise and compare the rationales on which these international expert guidelines were based and how these recommendations affect IV-MFT practices in paediatric acute and critical care. Although these guidelines recommend the use of isotonic fluids as a standard in IV-MFT, some discrepancies and uncertainties remain regarding the systematic use of balanced fluids, glucose and electrolyte requirements, and appropriate fluid volume. IV-MFT should be considered in the same way as any other prescription drug and none of the components of IV-MFT prescription should be overlooked (ie, choice of drug, dosing rate, duration of treatment, and de-escalation). Furthermore, most evidence that was used to inform the guidelines comes from high-income countries. Although some principles of IV-MFT are universal, the direct relevance to and feasibility of implementing the guidelines in low-income and middle-income countries is uncertain.

Published
2024
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169. Worldwide Survey of Nutritional Practices in PICUs*

Author

Kerklaan, Dorian, primary, Fivez, Tom, additional, Mehta, Nilesh M., additional, Mesotten, Dieter, additional, van Rosmalen, Joost, additional, Hulst, Jessie M., additional, Van den Berghe, Greet, additional, Joosten, Koen F. M., additional, and Verbruggen, Sascha C. A. T., additional

Published
2016
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170. Impact of withholding early parenteral nutrition completing enteral nutrition in pediatric critically ill patients (PEPaNIC trial): study protocol for a randomized controlled trial

Author

Fivez, Tom, primary, Kerklaan, Dorian, additional, Verbruggen, Sascha, additional, Vanhorebeek, Ilse, additional, Verstraete, Sören, additional, Tibboel, Dick, additional, Guerra, Gonzalo Garcia, additional, Wouters, Pieter J, additional, Joffe, Ari, additional, Joosten, Koen, additional, Mesotten, Dieter, additional, and Van den Berghe, Greet, additional

Published
2015
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171. Validation of ventilator-derived VCO2 measurements to determine energy expenditure in ventilated critically ill children.

Author

Kerklaan, Dorian, Augustus, Marjolein E., Hulst, Jessie M., van Rosmalen, Joost, Verbruggen, Sascha C.A.T., and Joosten, Koen F.M.

Abstract

Summary Background & aims Indirect calorimetry (IC) is considered the gold standard to determine resting energy expenditure (REE) but its availability in PICUs worldwide is limited. Ventilator-derived VCO 2 could potentially improve the possibility of performing REE measurements. We investigated whether ventilator-derived VCO 2 values are comparable to IC-derived VCO 2 values and can clinically be used in clinical practice to determine REE. Methods VCO 2 -values were simultaneously collected in mechanically ventilated children from IC (Deltatrac ® ) and Servo-I ® ventilator on a minute base over at least 10 min period of steady state. REE was calculated using the modified Weir formula (for IC) or REE = 5.5*VCO 2 (L/min)*1440 (for the Servo-I values) and compared with frequently used predictive equations by Schofield and the WHO to calculate REE. Results Measurements were performed in 41 children; median age 2 years. The mean relative difference between VCO 2 measured by IC and Servo-I ® was 15.6% (p = 0.002), and limits of agreement in the Bland–Altman analysis were wide. Comparable measurements, defined as a difference ≤10% between IC and Servo-I ® VCO 2 values, were seen in 18 (44%) children, but this proportion was 70% in children ≥15 kg. In this group, REE could be accurately predicted using Servo-I ® derived VCO 2 values and this method was superior to the use of predictive equations. The Servo-I ® derived VCO 2 values were not sufficiently accurate for the large proportion of children weighing <15 kg. Conclusions In children ≥15 kg, VCO 2 measurements of the Servo-I ® seem sufficiently accurate for use in clinical practice and may be used to determine energy expenditure in the future. [ABSTRACT FROM AUTHOR]

Published
2017
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172. Evidence for the use of parenteral nutrition in the pediatric intensive care unit.

Author

Fivez, Tom, Kerklaan, Dorian, Mesotten, Dieter, Verbruggen, Sascha, Joosten, Koen, and Van den Berghe, Greet

Abstract

Summary Background and aims During hospitalization in a pediatric intensive care unit (PICU), critically ill children are fed artificially. Administered via the preferred enteral route, caloric targets are often not reached. Hence, parenteral nutrition is given to this patient population. In this review we analyzed the available evidence from randomized controlled trials (RCTs) that supports the use of parenteral nutrition in children during critical illness. Methods A search strategy in Ovid MEDLINE and Ovid EMBASE was created and trial registries were screened to identify the relevant RCTs. Studies were included if they were randomized controlled trials, involved pediatric patients admitted to PICU, and compared different dosing/compositions of parenteral nutrition. Descriptive studies and reviews were excluded. Results Of the 584 articles identified by the search strategy, only 114 articles were retained after title screening. Further abstract and full text screening identified 6 small RCTs that compared two dosing/composition strategies of parenteral nutrition. These trials reported differences in surrogate endpoints without an effect on hard clinical endpoints. The RCTs observed improvements in these surrogate endpoints with the use of more calories or when parenteral glutamine or fish oil was added. Conclusions The few RCTs suggest that surrogate endpoints can be affected by providing parenteral nutrition to critically ill children, but the studies were not statistically powered to draw meaningful clinical conclusions. Large RCTs with clinically relevant outcome measures are urgently needed to support the current nutritional guidelines that advise the use of parenteral nutrition in the PICU. [ABSTRACT FROM AUTHOR]

Published
2017
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174. Early versus late parenteral nutrition in critically ill, term neonates: a preplanned secondary subgroup analysis of the PEPaNIC multicentre, randomised controlled trial

Author

van Puffelen, Esther, Vanhorebeek, Ilse, Joosten, Koen F M, Wouters, Pieter J, Van den Berghe, Greet, and Verbruggen, Sascha C A T

Abstract

Previous randomised studies showed that withholding parenteral nutrition for 1 week of critical illness was superior to early initiation (<24–48 h) of parenteral nutrition in children and adults. However, neonates are considered more susceptible to macronutrient deficits. We investigated the effect of withholding parenteral nutrition for 1 week in critically ill, term neonates.

Published
2018
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176. Effect of early supplemental parenteral nutrition in the paediatric ICU: a preplanned observational study of post-randomisation treatments in the PEPaNIC trial

Author

Vanhorebeek, Ilse, Verbruggen, Sascha, Casaer, Michaël P, Gunst, Jan, Wouters, Pieter J, Hanot, Jan, Guerra, Gonzalo Garcia, Vlasselaers, Dirk, Joosten, Koen, and Van den Berghe, Greet

Abstract

Large randomised controlled trials have shown that early supplemental parenteral nutrition in patients admitted to adult and paediatric intensive care units (PICUs) is harmful. Overdosing of energy with too little protein was suggested as a potential reason for this. This study analysed which macronutrient was associated with harm caused by early supplemental parenteral nutrition in the Paediatric Early versus Late Parenteral Nutrition In Critical Illness (PEPaNIC) randomised trial.

Published
2017
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183. Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study.

Author

I. de Betue, Carlijn T., A.T. Verbruggen, Sascha C., Schierbeek, Henk, Chacko, Shaji K., J.C. Bogers, Ad J., van Goudoever, Johannes B., and M. Joosten, Koen F.

Subjects
HYPERGLYCEMIA, BLOOD sugar, CARDIAC surgery, CARDIOPULMONARY bypass, ARTIFICIAL blood circulation
Abstract

Introduction: Hyperglycemia in children after cardiac surgery can be treated with intensive insulin therapy, but hypoglycemia is a potential serious side effect. The aim of this study was to investigate the effects of reducing glucose intake below standard intakes to prevent hyperglycemia, on blood glucose concentrations, glucose kinetics and protein catabolism in children after cardiac surgery with cardiopulmonary bypass (CPB). Methods: Subjects received a 4-hour low glucose (LG; 2.5 mg/kg per minute) and a 4-hour standard glucose (SG; 5.0 mg/kg per minute) infusion in a randomized blinded crossover setting. Simultaneously, an 8-hour stable isotope tracer protocol was conducted to determine glucose and leucine kinetics. Data are presented as mean ± SD or median (IQR); comparison was made by paired samples t test. Results: Eleven subjects (age 5.1 (20.2) months) were studied 9.5 ± 1.9 hours post-cardiac surgery. Blood glucose concentrations were lower during LG than SG (LG 7.3 ± 0.7 vs. SG 9.3 ± 1.8 mmol/L; P < 0.01), although the glycemic target (4.0-6.0 mmol/L) was not achieved. No hypoglycemic events occurred. Endogenous glucose production was higher during LG than SG (LG 2.9 ± 0.8 vs. SG 1.5 ± 1.1 mg/kg per minute; P = 0.02), due to increased glycogenolysis (LG 1.0 ± 0.6 vs. SG 0.0 ± 1.0 mg/kg per minute; P < 0.05). Leucine balance, indicating protein balance, was negative but not affected by glucose intake (LG -54.8 ± 14.6 vs. SG -58.8 ± 16.7 μmol/kg per hour; P = 0.57). Conclusions: Currently recommended glucose intakes aggravated hyperglycemia in children early after cardiac surgery with CPB. Reduced glucose intake decreased blood glucose concentrations without causing hypoglycemia or affecting protein catabolism, but increased glycogenolysis. Trial registration: Dutch trial register NTR2079. [ABSTRACT FROM AUTHOR]

Published
2012
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184. Efficacy and Safety of a Tight Glucose Control Protocol in Critically Ill Term Neonates.

Author

Verbruggen, Sascha C., Landzaat, Lonneke J., Reiss, Irwin K.M., van Goudoever, Johannes B., and Joosten, Koen F.M.

Subjects
*BLOOD sugar monitoring, *NEONATAL diseases, *NEWBORN infant physiology, *HYPERGLYCEMIA, *PEDIATRIC intensive care
Abstract

Background: A large single-center randomized trial showed that treating hyperglycemia in critically ill children improved outcome, despite an increased incidence of hypoglycemia, especially in infants. Objectives: We evaluated the efficacy and incidence of hypoglycemia using a tight glucose protocol in critically ill term neonates. Methods: Term hyperglycemic (>8 mmol·l-1; >144 mg·dl-1) neonates treated with a tight glucose protocol during a 3.5-year period in a tertiary pediatric intensive care unit were retrospectively analyzed. Results: Seventy-three term hyperglycemic neonates [age 0 days (0-6), weight 3.2 ± 0.8 kg, PRISM 16 (11-20)] were included for analysis. Eighteen neonates died (25%). The initial mean (range) glucose level was 11.1 mmol·l-1 [9.6-15.2; 200 mg·dl-1 (173-274)], and normoglycemia (<8 mmol·l-1; <144 mg·dl-1) was reached within 5.3 h (1-25) with an overall treatment duration of 27 h (10-57). Seven hypoglycemic incidents (5 times ≤2.2 mmol·l-1; 40 mg·dl-1, and 2 times <1.7 mmol·l-1; 31 mg·dl-1) occurred in 5 (6.7%) infants, without severe clinical signs. Three hypoglycemic incidents were directly explained due to a protocol violation. One hypoglycemic incident occurred with the onset of sepsis, while no apparent cause was identified for three hypoglycemic incidents. Conclusions: Our glucose protocol was effective, but hypoglycemia occurred more frequently than in older children reported previously. Potential differences in glucose and insulin metabolism in term neonates appear to justify additional safety approaches, while awaiting further studies assessing the benefits of tight glucose protocols in this population. Meanwhile, we have decreased the initial insulin starting doses in our protocol. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2012
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185. Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit.

Author

De Bruyn, Astrid, Gunst, Jan, Goossens, Chloë, Vander Perre, Sarah, Guerra, Gonzalo G., Verbruggen, Sascha, Joosten, Koen, Langouche, Lies, and Van den Berghe, Greet

Subjects
INTENSIVE care units, RESEARCH, RESEARCH methodology, PEDIATRICS, EVALUATION research, MEDICAL cooperation, TREATMENT effectiveness, COMPARATIVE studies, IMPACT of Event Scale, RESEARCH funding, PARENTERAL feeding, PASSIVE euthanasia, KETONES
Abstract

Background: In critically ill children, omitting early use of parenteral nutrition (late-PN versus early-PN) reduced infections, accelerated weaning from mechanical ventilation, and shortened PICU stay. We hypothesized that fasting-induced ketogenesis mediates these benefits.Methods: In a secondary analysis of the PEPaNIC RCT (N = 1440), the impact of late-PN versus early-PN on plasma 3-hydroxybutyrate (3HB), and on blood glucose, plasma insulin, and glucagon as key ketogenesis regulators, was determined for 96 matched patients staying ≥ 5 days in PICU, and the day of maximal 3HB-effect, if any, was identified. Subsequently, in the total study population, plasma 3HB and late-PN-affected ketogenesis regulators were measured on that average day of maximal 3HB effect. Multivariable Cox proportional hazard and logistic regression analyses were performed adjusting for randomization and baseline risk factors. Whether any potential mediator role for 3HB was direct or indirect was assessed by further adjusting for ketogenesis regulators.Results: In the matched cohort (n = 96), late-PN versus early-PN increased plasma 3HB throughout PICU days 1-5 (P < 0.0001), maximally on PICU day 2. Also, blood glucose (P < 0.001) and plasma insulin (P < 0.0001), but not glucagon, were affected. In the total cohort (n = 1142 with available plasma), late-PN increased plasma 3HB on PICU day 2 (day 1 for shorter stayers) from (median [IQR]) 0.04 [0.04-0.04] mmol/L to 0.75 [0.04-2.03] mmol/L (P < 0.0001). The 3HB effect of late-PN statistically explained its impact on weaning from mechanical ventilation (P = 0.0002) and on time to live PICU discharge (P = 0.004). Further adjustment for regulators of ketogenesis did not alter these findings.Conclusion: Withholding early-PN in critically ill children significantly increased plasma 3HB, a direct effect that statistically mediated an important part of its outcome benefit. [ABSTRACT FROM AUTHOR]

Published
2020
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186. International survey of De-implementation of initiating parenteral nutrition early in Paediatric intensive care units.

Author

van Puffelen, Esther, Jacobs, An, Verdoorn, Charlotte J. M., Joosten, Koen F. M., van den Berghe, Greet, Ista, Erwin, and Verbruggen, Sascha C. A. T.

Subjects
INTENSIVE care units, PARENTERAL feeding, CRITICALLY ill children
Abstract

Background: Initiating parenteral nutrition (PN) within 24 h in critically ill children is inferior to withholding PN during the first week, as was found in the PEPaNIC study. The aims of this study were to investigate de-implementation of early initiation of PN at PICUs worldwide, and to identify factors influencing de-implementation.Methods: A cross-sectional online survey was conducted (May - October 2017), consisting of 41 questions addressing current PN practices, the degree of de-implementation, and factors affecting de-implementation.Results: We analysed 81 responses from 39 countries. Of these 81 respondents, 53 (65%) were aware of the findings of the PEPaNIC study, and 43 (53%) have read the article. In these 43 PICUs, PN was completely withheld during the first week in 10 PICUs, of which 5 already withheld PN (12%), and 5 de-implemented early initiation of PN (12%). Partial de-implementation was reported by 17 (40%) and no de-implementation by 16 (37%). Higher de-implementation rates were observed when the interpreted level of evidence and grade of recommendation of PEPaNIC was high. Predominant reasons for retaining early initiation of PN were concerns on withholding amino acids, the safety in undernourished children and neonates, and the long-term consequences. Furthermore, the respondents were waiting for updated guidelines.Conclusions: One year after the publication of the PEPaNIC trial, only two-thirds of the respondents was aware of the study results. Within this group, early initiation of PN was de-implemented completely in 12% of the PICUs, while 40% asserted partial de-implementation. Increasing the awareness, addressing the intervention-specific questions and more frequently revising international guidelines might help to accelerate de-implementation of ineffective, unproven or harmful healthcare. [ABSTRACT FROM AUTHOR]

Published
2019
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187. Additional file 2: of Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial

Author

Puffelen, Esther Van, Polinder, Suzanne, Vanhorebeek, Ilse, Wouters, Pieter, Bossche, Niek, Peers, Guido, Sรถren Verstraete, Joosten, Koen, Berghe, Greet Van Den, Verbruggen, Sascha, and Mesotten, Dieter

Subjects
3. Good health
Abstract

Table showing total healthcare costs split by age into two groups. (DOC 28 kb)

188. Additional file 3: of Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial

Author

Puffelen, Esther Van, Polinder, Suzanne, Vanhorebeek, Ilse, Wouters, Pieter, Bossche, Niek, Peers, Guido, Sรถren Verstraete, Joosten, Koen, Berghe, Greet Van Den, Verbruggen, Sascha, and Mesotten, Dieter

Subjects
3. Good health
Abstract

Table showing total healthcare costs split by diagnosis into four groups. (DOC 31 kb)

189. Additional file 3 of Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

Author

Verlinden, Ines, Güiza, Fabian, Derese, Inge, Wouters, Pieter J., Joosten, Koen, Verbruggen, Sascha C., Berghe, Greet Van Den, and Vanhorebeek, Ilse

Subjects
3. Good health
Abstract

Additional file 3. Total energy intake of early-PN and late-PN patients on the first 7 days in PICU. Bar graphs showing total energy intake of early-PN and late-PN patients on the first 7 days in PICU.

194. Additional file 6 of Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

Author

Verlinden, Ines, Güiza, Fabian, Derese, Inge, Wouters, Pieter J., Joosten, Koen, Verbruggen, Sascha C., Berghe, Greet Van Den, and Vanhorebeek, Ilse

Subjects
3. Good health
Abstract

Additional file 6. Evolution of DNA methylation over time of pattern 1–4 in individual critically ill patients. Detailed time profiles are shown for ten patients of representative CpG-sites classified to pattern 1, pattern 2, pattern 3, and pattern 4.

195. Additional file 1 of Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Author

Hordijk, José, Verbruggen, Sascha, Vanhorebeek, Ilse, Güiza, Fabian, Wouters, Pieter, Berghe, Greet Van Den, Joosten, Koen, and Dulfer, Karolijn

Subjects
3. Good health
Abstract

Additional file 1. Psychometric characteristics of the questionnaires and additional information about variables for analyses.

197. Additional file 3 of Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Author

Hordijk, José, Verbruggen, Sascha, Vanhorebeek, Ilse, Güiza, Fabian, Wouters, Pieter, Berghe, Greet Van Den, Joosten, Koen, and Dulfer, Karolijn

Subjects
humanities, 3. Good health
Abstract

Additional file 3. Pooled univariable analyses of the differences in HRQoL outcomes between study groups.

199. Additional file 2: of Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial

Author

Puffelen, Esther Van, Polinder, Suzanne, Vanhorebeek, Ilse, Wouters, Pieter, Bossche, Niek, Peers, Guido, Sรถren Verstraete, Joosten, Koen, Berghe, Greet Van Den, Verbruggen, Sascha, and Mesotten, Dieter

Subjects
3. Good health
Abstract

Table showing total healthcare costs split by age into two groups. (DOC 28 kb)

200. Additional file 5 of Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

Author

Verlinden, Ines, Güiza, Fabian, Derese, Inge, Wouters, Pieter J., Joosten, Koen, Verbruggen, Sascha C., Berghe, Greet Van Den, and Vanhorebeek, Ilse

Subjects
3. Good health
Abstract

Additional file 5. Summary of ANOVA results comparing DNA methylation levels in patients at different time points during PICU stay versus healthy children. DNA methylation levels of the 147 CpG-sites that were not yet differentially methylated in patients upon PICU admission versus healthy children were compared for patients at day 3, day 5 and day 7 in PICU versus healthy children with the use of ANOVA and application of a false discovery rate of 0.05, with reporting of unadjusted p values.

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