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151. Impact of risk-reducing salpingo-oophorectomy on lipid determinants, HbA1c and CRP.

Author

Vermeulen, R. F. M., van Altena, J. L., Gaarenstroom, K. N., van Beurden, M., Kieffer, J. K., Aaronson, N. K., Kenter, G. G., and Korse, C. M.

Subjects
*GLYCOSYLATED hemoglobin, *SALPINGO-oophorectomy, *LIPIDS, *C-reactive protein, *HIGH density lipoproteins
Abstract

Risk-reducing salpingo-oophorectomy (RRSO) is advised before 40–45 years of age for BRCA1/2 mutation carriers. This study describes the effect of RRSO on lipid determinants, hemoglobin A1c (HbA1c) and C-reactive protein (CRP). A total of 142 women with increased risk of ovarian cancer were included, 92 premenopausal and 50 postmenopausal. Serum levels of low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and total cholesterol, triglycerides, HbA1c and CRP were determined at three points in time: before (T0) and 6 weeks (T1) and 7 months (T2) following RRSO. The Hot Flush Rating Scale was administered at the same time points. In premenopausal women, levels of HDL-cholesterol, the cholesterol ratio and HBA1c increased significantly over time, although still staying within the reference range. In this group, hot flushes increased over time (p < 0.001). In postmenopausal women, no significant changes were observed following RRSO. At T2, serum LDL-cholesterol, triglycerides, HbA1c and CRP were significantly lower in premenopausal women compared to postmenopausal women, whereas HDL was increased. Seven months after RRSO, the lipid profile in premenopausal women had changed, although still staying within the reference range. For postmenopausal women, we did not observe any significant changes. Our results do not suggest a worsening of cardiovascular risk within 7 months of RRSO. [ABSTRACT FROM AUTHOR]

Published
2023
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152. Measuring a Cherenkov ring in the radio emission from air showers at 110–190 MHz with LOFAR

Author

Nelles, A., Schellart, P., Buitink, S., Corstanje, A., de Vries, K.D., Enriquez, J.E., Falcke, H., Frieswijk, W., Hörandel, J.R., Scholten, O., ter Veen, S., Thoudam, S., van den Akker, M., Anderson, J., Asgekar, A., Bell, M.E., Bentum, M.J., Bernardi, G., Best, P., Bregman, J., Breitling, F., Broderick, J., Brouw, W.N., Brüggen, M., Butcher, H.R., Ciardi, B., Deller, A., Duscha, S., Eislöffel, J., Fallows, R.A., Garrett, M.A., Gunst, A.W., Hassall, T.E., Heald, G., Horneffer, A., Iacobelli, M., Juette, E., Karastergiou, A., Kondratiev, V.I., Kramer, M., Kuniyoshi, M., Kuper, G., Maat, P., Mann, G., Mevius, M., Norden, M.J., Paas, H., Pandey-Pommier, M., Pietka, G., Pizzo, R., Polatidis, A.G., Reich, W., Röttgering, H., Scaife, A.M.M., Schwarz, D., Smirnov, O., Stappers, B.W., Steinmetz, M., Stewart, A., Tagger, M., Tang, Y., Tasse, C., Vermeulen, R., Vocks, C., van Weeren, R.J., Wijnholds, S.J., Wucknitz, O., Yatawatta, S., and Zarka, P.

Published
2015
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153. The shape of the radio wavefront of extensive air showers as measured with LOFAR

Author

Corstanje, A., Schellart, P., Nelles, A., Buitink, S., Enriquez, J.E., Falcke, H., Frieswijk, W., Hörandel, J.R., Krause, M., Rachen, J.P., Scholten, O., ter Veen, S., Thoudam, S., Trinh, T.N.G., van den Akker, M., Alexov, A., Anderson, J., Avruch, I.M., Bell, M.E., Bentum, M.J., Bernardi, G., Best, P., Bonafede, A., Breitling, F., Broderick, J., Brüggen, M., Butcher, H.R., Ciardi, B., de Gasperin, F., de Geus, E., de Vos, M., Duscha, S., Eislöffel, J., Engels, D., Fallows, R.A., Ferrari, C., Garrett, M.A., Grießmeier, J., Gunst, A.W., Hamaker, J.P., Hoeft, M., Horneffer, A., Iacobelli, M., Juette, E., Karastergiou, A., Kohler, J., Kondratiev, V.I., Kuniyoshi, M., Kuper, G., Maat, P., Mann, G., McFadden, R., McKay-Bukowski, D., Mevius, M., Munk, H., Norden, M.J., Orru, E., Paas, H., Pandey-Pommier, M., Pandey, V.N., Pizzo, R., Polatidis, A.G., Reich, W., Röttgering, H., Scaife, A.M.M., Schwarz, D., Smirnov, O., Stewart, A., Steinmetz, M., Swinbank, J., Tagger, M., Tang, Y., Tasse, C., Toribio, C., Vermeulen, R., Vocks, C., van Weeren, R.J., Wijnholds, S.J., Wucknitz, O., Yatawatta, S., and Zarka, P.

Published
2015
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156. Risk of Bias Assessments and Evidence Syntheses for Observational Epidemiologic Studies of Environmental and Occupational Exposures: Strengths and Limitations

Author

Steenland, Kyle, Schubauer-Berigan, M.K., Vermeulen, R., Lunn, R.M., Straif, K., Zahm, S., Stewart, P., Arroyave, W.D., Mehta, S.S., and Pearce, N.

Subjects
United States. Environmental Protection Agency, Animal behavior, Environmental issues, Health
Abstract

BACKGROUND: Increasingly, risk of bias tools are used to evaluate epidemiologic studies as part of evidence synthesis (evidence integration), often involving meta-analyses. Some of these tools consider hypothetical randomized controlled trials (RCTs) as gold standards. METHODS: We review the strengths and limitations of risk of bias assessments, in particular, for reviews of observational studies of environmental exposures, and we also comment more generally on methods of evidence synthesis. RESULTS: Although RCTs may provide a useful starting point to think about bias, they do not provide a gold standard for environmental studies. Observational studies should not be considered inherently biased vs. a hypothetical RCT. Rather than a checklist approach when evaluating individual studies using risk of bias tools, we call for identifying and quantifying possible biases, their direction, and their impacts on parameter estimates. As is recognized in many guidelines, evidence synthesis requires a broader approach than simply evaluating risk of bias in individual studies followed by synthesis of studies judged unbiased, or with studies given more weight if judged less biased. It should include the use of classical considerations for judging causality in human studies, as well as triangulation and integration of animal and mechanistic data. CONCLUSIONS: Bias assessments are important in evidence synthesis, but we argue they can and should be improved to address the concerns we raise here. Simplistic, mechanical approaches to risk of bias assessments, which may particularly occur when these tools are used by nonexperts, can result in erroneous conclusions and sometimes may be used to dismiss important evidence. Evidence synthesis requires a broad approach that goes beyond assessing bias in individual human studies and then including a narrow range of human studies judged to be unbiased in evidence synthesis. https://doi.org/10.1289/EHP6980, Introduction Evidence synthesis (or evidence integration) is widely used to summarize findings of epidemiologic studies of environmental and occupational exposures. Such syntheses are part of systematic reviews of observational epidemiologic [...]

Published
2020
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157. Effectiveness of functional intensive therapy on mobility and self-care activities in children and adolescents with cerebral palsy - a prospective clinical study

Author

Janssen-Potten, Yvonne J M, Roks, Lars, Roijen, Ruud, Vermeulen, R Jeroen, Rameckers, Eugène E A, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Revalidatiegeneeskunde, and RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation

Abstract

PURPOSE: Cerebral palsy (CP) is a major cause of childhood disability. Children with CP often lack motor skills to effectively perform activities of daily living. The aim is to assess the effectiveness of a functional intensive therapy program focused on improving individual goals in the domain of mobility and self-care in children and adolescents with CP. MATERIAL AND METHODS: Thirty-five CP patients, aged 11-19 years, GMFCS I-IV, received daily 6-7 h of functional therapy for 15 days. Outcomes were assessed at baseline, immediately after the program and at three months follow-up. RESULTS: Significant post-intervention improvement was seen on all primary and secondary outcome measures; personal goals (GAS score; COPM performance and COPM satisfaction), daily activities (ACTIVLIM), hand function (ABILHAND-Kids), mobility (ABILOCO-Kids; GMFM-66-IS score). There was no loss to follow up during the program and after three months. At follow-up, improvements were retained except for ABILOCO and GMFM-66-IS. CONCLUSIONS: Functional intensive therapy appears feasible and seems to be effective in improving treatment goals focused on mobility and self-care, even in older and more severely affected children and adolescents with CP. After three months, these possible effects were still present.Implications for rehabilitationShort intensive functional training is feasible and showing no loss to follow up in the older and more severely affected children and adolescents with cerebral palsy (CP).Short intensive functional training appears effective in improving individual goals in children and adolescents with CP and improvements endorse three months.Short intensive functional training seems to be effective on both mobility and self-care domains of the ICF-CY.

Published
2022

159. Polymorphic variants involved in methylation regulation: a new strategy to discover risk loci for pancreatic ductal adenocarcinoma

Author

Corradi, Chiara, primary, Lencioni, G., additional, Gentiluomo, M., additional, Latiano, A., additional, Kiudelis, G., additional, van Eijck, C., additional, Marta, K., additional, Lawlor, R., additional, Tavano, F., additional, Boggi, U., additional, Dijk, F., additional, Cavestro, G., additional, Vermeulen, R., additional, Hackert, T., additional, Petrone, M., additional, Uzunoglu, F., additional, Archibugi, L., additional, Izbicki, J., additional, Mesquita, B. Bueno-de-, additional, Morelli, L., additional, Zerbi, A., additional, Stocker, H., additional, Talar-Wojnarowska, R., additional, Di Franco, G., additional, Hegyi, P., additional, Sperti, C., additional, Carrara, S., additional, Capurso, G., additional, Gazouli, M., additional, Brenner, H., additional, Bunduc, S., additional, Busch, O., additional, Landi, S., additional, Perri, F., additional, Oliverius, M., additional, Goetz, M., additional, Scognamiglio, P., additional, Mambrini, A., additional, Arcidiacono, P., additional, Kreivenaite, E., additional, Kupcinskas, J., additional, Hussein, T., additional, Ermini, S., additional, Milanetto, A., additional, Vodicka, P., additional, Kiudelis, V., additional, Hlavac, V., additional, Soucek, P., additional, Theodoropoulos, G., additional, Basso, D., additional, Aoki, M., additional, Pezzilli, R., additional, Pasquali, C., additional, Chammas, R., additional, Testoni, S., additional, Mohelníková-Duchoňová, B., additional, Lucchesi, M., additional, Neoptolemos, J., additional, Canzian, F., additional, and Campa, D., additional

Published
2022
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161. Depression, anxiety and the risk of breast cancer among premenopausal and postmenopausal women: an individual participant data meta-analysis

Author

Basten, M., primary, van Tuijl, L.A., additional, Pan, K.Y., additional, Spaan, M., additional, de Graeff, A., additional, Dekker, J., additional, Hoogendoorn, A.W., additional, Lamers, F., additional, Ranchor, A.V., additional, Vermeulen, R., additional, Voogd, A.C., additional, and Geerlings, M.I., additional

Published
2022
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162. Clinical Utility of Eye Tracking in Assessing Distractibility in Children with Neurological Disorders or ADHD: A Cross-Sectional Study

Author

Sweere, Dirk J. J., primary, Pel, Johan J. M., additional, Kooiker, Marlou J. G., additional, van Dijk, Johannes P., additional, van Gemert, Elizabeth J. J. M., additional, Hurks, Petra P. M., additional, Klinkenberg, Sylvia, additional, Vermeulen, R. Jeroen, additional, and Hendriksen, Jos G. M., additional

Published
2022
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169. Brain Structure and Executive Functions in Children with Cerebral Palsy: A Systematic Review

Author

Weierink, Lonneke, Vermeulen, R. Jeroen, and Boyd, Roslyn N.

Abstract

This systematic review aimed to establish the current knowledge about brain structure and executive function (EF) in children with cerebral palsy (CP). Five databases were searched (up till July 2012). Six articles met the inclusion criteria, all included structural brain imaging though no functional brain imaging. Study quality was assessed using the STROBE checklist. All articles scored between 58.7% and 70.5% for quality (100% is the maximum score). The included studies all reported poorer performance on EF tasks for children with CP compared to children without CP. For the selected EF measures non-significant effect sizes were found for the CP group compared to a semi-control group (children without cognitive deficits but not included in a control group). This could be due to the small sample sizes, group heterogeneity and lack of comparison of the CP group to typically developing children. The included studies did not consider specific brain areas associated with EF performance. To conclude, there is a paucity of brain imaging studies focused on EF in children with CP, especially of studies that include functional brain imaging. Outcomes of the present studies are difficult to compare as each study included different EF measures and cortical abnormality measures. (Contains 1 figure, 3 tables, and 1 note.)

Published
2013
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172. Motor Testing at 1 Year Improves the Prediction of Motor and Mental Outcome at 2 Years after Perinatal Hypoxic-Ischaemic Encephalopathy

Author

van Schie, Petra Em, Becher, Jules G., Dallmeijer, Annet J., Barkhof, Frederik, van Weissenbruch, Mirjam M., and Vermeulen, R. Jeroen

Abstract

Aim: To investigate the predictive value of motor testing at 1 year for motor and mental outcome at 2 years after perinatal hypoxic-ischaemic encephalopathy (HIE) in term neonates. Method: Motor and mental outcome at 2 years was assessed with the Bayley Scales of Infant Development, 2nd edition (BSID-II) in 32 surviving children (20 males, 12 females; mean gestational age 40.2 wk, SD 1.4; mean birthweight 3217g, SD 435) participating in a prospective cohort study of HIE. The predictive value of three motor tests (Alberta Infant Motor Scale [AIMS], BSID-II, and the Neurological Optimality Score [NOS]) at 1 year was analysed, in addition to predictions based on neonatal Sarnat staging and magnetic resonance imaging (MRI). Poor motor test results were defined as an AIMS z-score of less than -2, a psychomotor developmental index of the BSID-II of less than 70, or a NOS of less than 26. Poor motor and poor mental outcome at 2 years was defined as a psychomotor developmental index or mental developmental index of the BSID-II of less than 70. Results: Twelve children, all with Sarnat grade II, had a poor motor outcome and 12 children, of whom one had Sarnat grade I, had a poor mental outcome at 2 years. Nine children had cerebral palsy, of whom five had quadriplegia, three had dyskinesia, and one had hemiplegia. Poor motor tests at 1 year increased the probability of a poor motor outcome from 71% (range 92 to 100%), and a poor mental outcome from 59% (range 77 to 100%) in children with Sarnat grade II and abnormal MRI, assessed with the AIMS and BSID-II or NOS respectively. Interpretation: Additional motor testing at 1 year improves the prediction of motor and mental outcome at 2 years in children with Sarnat grade II and abnormal MRI. (Contains 5 tables.)

Published
2010
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173. Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR

Author

Peters, S, Vlaanderen, J, Portengen, L, Vermeulen, R, Visser, A, Veldink, J, Van Den Berg, L, D'Ovidio, F, Chio, A, Beghi, E, Pupillo, E, Logroscino, G, Hardiman, O, Van Der Kooi, A, Raaphorst, J, Calvo, A, Moglia, C, Casale, F, Fuda, G, Canosa, A, Manera, U, Bombaci, A, Grassano, M, Vasta, R, Salamone, P, Marrali, G, Iazzolino, B, Mazzini, L, Rooney, J, Heverin, M, Vajda, A, Comi, G, Riva, N, Lunetta, C, Gerardi, F, Filosto, M, Cotelli, M, Rinaldi, F, Chiveri, L, Guaita, M, Perrone, P, Mauro, C, Diamanti, L, Ferrarese, C, Tremolizzo, L, Delodovici, M, Bono, G, Tortelli, R, Zecca, C, Peters S., Vlaanderen J., Portengen L., Vermeulen R., Visser A. E., Veldink J. H., Van Den Berg L. H., D'Ovidio F., Chio A., Beghi E., Pupillo E., Logroscino G., Hardiman O., Van Der Kooi A. J., Raaphorst J., Calvo A., Moglia C., Casale F., Fuda G., Canosa A., Manera U., Bombaci A., Grassano M., Vasta R., Salamone P., Marrali G., Iazzolino B., Mazzini L., Rooney J., Heverin M., Vajda A., Comi G., Riva N., Lunetta C., Gerardi F., Filosto M., Cotelli M. S., Rinaldi F., Chiveri L., Guaita M. C., Perrone P., Mauro C., Diamanti L., Ferrarese C., Tremolizzo L., Delodovici M. L., Bono G., Tortelli R., Zecca C., Peters, S, Vlaanderen, J, Portengen, L, Vermeulen, R, Visser, A, Veldink, J, Van Den Berg, L, D'Ovidio, F, Chio, A, Beghi, E, Pupillo, E, Logroscino, G, Hardiman, O, Van Der Kooi, A, Raaphorst, J, Calvo, A, Moglia, C, Casale, F, Fuda, G, Canosa, A, Manera, U, Bombaci, A, Grassano, M, Vasta, R, Salamone, P, Marrali, G, Iazzolino, B, Mazzini, L, Rooney, J, Heverin, M, Vajda, A, Comi, G, Riva, N, Lunetta, C, Gerardi, F, Filosto, M, Cotelli, M, Rinaldi, F, Chiveri, L, Guaita, M, Perrone, P, Mauro, C, Diamanti, L, Ferrarese, C, Tremolizzo, L, Delodovici, M, Bono, G, Tortelli, R, Zecca, C, Peters S., Vlaanderen J., Portengen L., Vermeulen R., Visser A. E., Veldink J. H., Van Den Berg L. H., D'Ovidio F., Chio A., Beghi E., Pupillo E., Logroscino G., Hardiman O., Van Der Kooi A. J., Raaphorst J., Calvo A., Moglia C., Casale F., Fuda G., Canosa A., Manera U., Bombaci A., Grassano M., Vasta R., Salamone P., Marrali G., Iazzolino B., Mazzini L., Rooney J., Heverin M., Vajda A., Comi G., Riva N., Lunetta C., Gerardi F., Filosto M., Cotelli M. S., Rinaldi F., Chiveri L., Guaita M. C., Perrone P., Mauro C., Diamanti L., Ferrarese C., Tremolizzo L., Delodovici M. L., Bono G., Tortelli R., and Zecca C.

Abstract

Background We investigated the association between cigarette smoking and risk of amyotrophic lateral sclerosis (ALS) in a pooled analysis of population-based case-control studies and explored the independent effects of intensity, duration and time-since-quitting. Methods ALS cases and controls, matched by age, sex and region, were recruited in the Netherlands, Italy and Ireland (∗Euro-MOTOR project). Demographics and detailed lifetime smoking histories were collected through questionnaires. Effects of smoking status, intensity (cigarettes/day), duration (years), pack-years and time-since-quitting (years) on ALS risk were estimated using logistic regression models, adjusting for age, sex, alcohol, education and centre. We further investigated effect modification of the linear effects of pack-years by intensity, duration and time-since-quitting using excess OR (eOR) models. Results Analyses were performed on 1410 cases and 2616 controls. Pack-years were positively associated with ALS risk; OR=1.26 (95%CI: 1.03 to 1.54) for the highest quartile compared with never smokers. This association appeared to be predominantly driven by smoking duration (p trend=0.001) rather than intensity (p trend=0.86), although the trend for duration disappeared after adjustment for time-since-quitting. Time-since-quitting was inversely related to ALS (p trend <0.0001). The eOR decreased with time-since-quitting smoking, until about 10 years prior to disease onset. High intensity smoking with shorter duration appeared more deleterious than lower intensity for a longer duration. Conclusions Our findings provide further support for the association between smoking and ALS. Pack-years alone may be insufficient to capture effects of different smoking patterns. Time-since-quitting appeared to be an important factor, suggesting that smoking may be an early disease trigger.

Published
2020

175. Synchronous X-ray and Radio Mode Switches: A Rapid Global Transformation of the Pulsar Magnetosphere

Author

Hermsen, W., Hessels, J. W. T., Kuiper, L., van Leeuwen, J., Mitra, D., de Plaa, J., Rankin, J. M., Stappers, B. W., Wright, G. A. E., Basu, R., Alexov, A., Coenen, T., Grießmeier, J.-M., Hassall, T. E., Karastergiou, A., Keane, E., Kondratiev, V. I., Kramer, M., Kuniyoshi, M., Noutsos, A., Serylak, M., Pilia, M., Sobey, C., Weltevrede, P., Zagkouris, K., Asgekar, A., Avruch, I. M., Batejat, F., Bell, M. E., Bell, M. R., Bentum, M. J., Bernardi, G., Best, P., Bîrzan, L., Bonafede, A., Breitling, F., Broderick, J., Brüggen, M., Butcher, H. R., Ciardi, B., Duscha, S., Eislöffel, J., Falcke, H., Fender, R., Ferrari, C., Frieswijk, W., Garrett, M. A., de Gasperin, F., de Geus, E., Gunst, A. W., Heald, G., Hoeft, M., Horneffer, A., Iacobelli, M., Kuper, G., Maat, P., Macario, G., Markoff, S., McKean, J. P., Mevius, M., Miller-Jones, J. C. A., Morganti, R., Munk, H., Orrú, E., Paas, H., Pandey-Pommier, M., Pandey, V. N., Pizzo, R., Polatidis, A. G., Rawlings, S., Reich, W., Röttgering, H., Scaife, A. M. M., Schoenmakers, A., Shulevski, A., Sluman, J., Steinmetz, M., Tagger, M., Tang, Y., Tasse, C., Veen, S. ter, Vermeulen, R., van de Brink, R. H., van Weeren, R. J., Wijers, R. A. M. J., Wise, M. W., Wucknitz, O., Yatawatta, S., and Zarka, P.

Published
2013
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176. Applying the exposome concept to working life health:The EU EPHOR project

Author

Pronk, A, Loh, M, Kuijpers, E, Albin, M, Selander, J, Godderis, L, Ghosh, M, Vermeulen, R, Peters, S, Mehlum, IS, Turner, MC, Schlünssen, V, Goldberg, M, Kogevinas, M, Harding, BN, Solovieva, S, Garani-Papadatos, T, van Tongeren, M, The EPHOR Consortium, and Stierum, R

Subjects
Global and Planetary Change, Exposome, Health, Epidemiology, Health, Toxicology and Mutagenesis, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, Toxicology and Mutagenesis, Noncommunicable disease, Public Health, Pollution, Occupational, Working life
Abstract

Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all occupational and related nonoccupational exposures. The latter includes nonoccupational exposures that may be directly or indirectly influenced by or interact with the working life of the individual in their relation to health. The Exposome Project for Health and Occupational Research aims to advance knowledge on the complex working life exposures in relation to disease beyond the single high exposure–single health outcome paradigm, mapping and relating interrelated exposures to inherent biological pathways, key body functions, and health. This will be achieved by combining (1) large-scale harmonization and pooling of existing European cohorts systematically looking at multiple exposures and diseases, with (2) the collection of new high-resolution external and internal exposure data. Methods and tools to characterize the working life exposome will be developed and applied, including sensors, wearables, a harmonized job exposure matrix (EuroJEM), noninvasive biomonitoring, omics, data mining, and (bio)statistics. The toolbox of developed methods and knowledge will be made available to policy makers, occupational health practitioners, and scientists. Advanced knowledge on working life exposures in relation to NCDs will serve as a basis for evidence-based and cost-effective preventive policies and actions. The toolbox will also enable future scientists to further expand the working life exposome knowledge base. ispartof: Environmental Epidemiology vol:6 issue:2 ispartof: location:United States status: Published online

Published
2022
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177. Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study

Author

Castaño-Vinyals, G, Sadetzki, S, Vermeulen, R, Momoli, F, Kundi, M, Merletti, F, Maslanyj, M, Calderon, C, Wiart, J, Lee, A-K, Taki, M, Sim, M, Armstrong, B, Benke, G, Schattner, R, Hutter, H-P, Krewski, D, Mohipp, C, Ritvo, P, Spinelli, J, Lacour, B, Remen, T, Radon, K, Weinmann, T, Petridou, E Th, Moschovi, M, Pourtsidis, A, Oikonomou, K, Kanavidis, P, Bouka, E, Dikshit, R, Nagrani, R, Chetrit, A, Bruchim, R, Maule, M, Migliore, E, Filippini, G, Miligi, L, Mattioli, S, Kojimahara, N, Yamaguchi, N, Ha, M, Choi, K, Kromhout, H, Goedhart, G, 't Mannetje, A, Eng, A, Langer, C E, Alguacil, J, Aragonés, N, Morales-Suárez-Varela, M, Badia, F, Albert, A, Carretero, G, Cardis, E, Castaño-Vinyals, G, Sadetzki, S, Vermeulen, R, Momoli, F, Kundi, M, Merletti, F, Maslanyj, M, Calderon, C, Wiart, J, Lee, A-K, Taki, M, Sim, M, Armstrong, B, Benke, G, Schattner, R, Hutter, H-P, Krewski, D, Mohipp, C, Ritvo, P, Spinelli, J, Lacour, B, Remen, T, Radon, K, Weinmann, T, Petridou, E Th, Moschovi, M, Pourtsidis, A, Oikonomou, K, Kanavidis, P, Bouka, E, Dikshit, R, Nagrani, R, Chetrit, A, Bruchim, R, Maule, M, Migliore, E, Filippini, G, Miligi, L, Mattioli, S, Kojimahara, N, Yamaguchi, N, Ha, M, Choi, K, Kromhout, H, Goedhart, G, 't Mannetje, A, Eng, A, Langer, C E, Alguacil, J, Aragonés, N, Morales-Suárez-Varela, M, Badia, F, Albert, A, Carretero, G, and Cardis, E

Abstract

In recent decades, the possibility that use of mobile communicating devices, particularly wireless (mobile and cordless) phones, may increase brain tumour risk, has been a concern, particularly given the considerable increase in their use by young people. MOBI-Kids, a 14-country (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, the Netherlands, New Zealand, Spain) case-control study, was conducted to evaluate whether wireless phone use (and particularly resulting exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF)) increases risk of brain tumours in young people. Between 2010 and 2015, the study recruited 899 people with brain tumours aged 10 to 24 years old and 1,910 controls (operated for appendicitis) matched to the cases on date of diagnosis, study region and age. Participation rates were 72% for cases and 54% for controls. The mean ages of cases and controls were 16.5 and 16.6 years, respectively; 57% were males. The vast majority of study participants were wireless phones users, even in the youngest age group, and the study included substantial numbers of long-term (over 10 years) users: 22% overall, 51% in the 20-24-year-olds. Most tumours were of the neuroepithelial type (NBT; n = 671), mainly glioma. The odds ratios (OR) of NBT appeared to decrease with increasing time since start of use of wireless phones, cumulative number of calls and cumulative call time, particularly in the 15-19 years old age group. A decreasing trend in ORs was also observed with increasing estimated cumulative RF specific energy and ELF induced current density at the location of the tumour. Further analyses suggest that the large number of ORs below 1 in this study is unlikely to represent an unknown causal preventive effect of mobile phone exposure: they can be at least partially explained by differential recall by proxies and prodromal symptoms affecting phone use before diagnosis of the cases. W

Published
2022

178. Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies

Author

Casey, K., Olen, O., Ludvigsson, J.F., Carbonnel, F., Oldenburg, B., Gunter, M.J., Tjønneland, A., Grip, O., Amian, P., Barricarte, A., Bergmann, M.M., Boutron-Ruault, M.-C., Cross, A., Hart, A.R., Kaaks, R., Key, T., Chirlaque López, M.D., Luben, Robert, Masala, G., Manjer, J., Olsen, A., Overvad, K., Palli, D., Riboli, E., Sánchez, M.J., Tumino, R., Vermeulen, R., Verschuren, W.M.M., Wareham, N., Ananthakrishnan, A., Burke, K., Lopes, E.W., Lochhead, P., Chan, A.T., Wolk, A., Khalili, H., Casey, K., Olen, O., Ludvigsson, J.F., Carbonnel, F., Oldenburg, B., Gunter, M.J., Tjønneland, A., Grip, O., Amian, P., Barricarte, A., Bergmann, M.M., Boutron-Ruault, M.-C., Cross, A., Hart, A.R., Kaaks, R., Key, T., Chirlaque López, M.D., Luben, Robert, Masala, G., Manjer, J., Olsen, A., Overvad, K., Palli, D., Riboli, E., Sánchez, M.J., Tumino, R., Vermeulen, R., Verschuren, W.M.M., Wareham, N., Ananthakrishnan, A., Burke, K., Lopes, E.W., Lochhead, P., Chan, A.T., Wolk, A., and Khalili, H.

Abstract

Background and Aims: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body mass index (BMI) and waist-hip ratio and other lifestyle factors. Diagnoses of CD and UC were confirmed through medical records or ascertained using validated definitions. We used Cox proportional hazards modeling to calculate pooled multivariable-adjusted HRs (aHRs) and 95% confidence intervals (CIs). Results: Among 601,009 participants (age range, 18-98 years) with 10,110,018 person-years of follow-up, we confirmed 563 incident cases of CD and 1047 incident cases of UC. Obesity (baseline BMI ≥30 kg/m2) was associated with an increased risk of CD (pooled aHR, 1.34; 95% CI, 1.05-1.71, I2 = 0%) compared with normal BMI (18.5 to <25 kg/m2). Each 5 kg/m2 increment in baseline BMI was associated with a 16% increase in risk of CD (pooled aHR, 1.16; 95% CI, 1.05-1.22; I2 = 0%). Similarly, with each 5 kg/m2 increment in early adulthood BMI (age, 18-20 years), there was a 22% increase in risk of CD (pooled aHR, 1.22; 95% CI, 1.05-1.40; I2 = 13.6%). An increase in waist-hip ratio was associated with an increased risk of CD that did not reach statistical significance (pooled aHR across quartiles, 1.08; 95% CI, 0.97-1.19; I2 = 0%). No associations were observed between measures of obesity and risk of UC. Conclusions: In an adult population, obesity as measured by BMI was associated with an increased risk of older-onset CD but not UC.

Published
2022

179. Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde

Author

Cardenas, A., Vermeulen, R., Fadadu, R.P., Hubbard, A.E., Phillips, R.V., Zhang, L., Breeze, C., Hu, W., Wen, C., Huang, Y., Tang, X., Smith, M.T., Rothman, N., Lan, Q., Cardenas, A., Vermeulen, R., Fadadu, R.P., Hubbard, A.E., Phillips, R.V., Zhang, L., Breeze, C., Hu, W., Wen, C., Huang, Y., Tang, X., Smith, M.T., Rothman, N., and Lan, Q.

Abstract

Epigenetic aging biomarkers are associated with increased morbidity and mortality. We evaluated if occupational exposure to three established chemical carcinogens is associated with acceleration of epigenetic aging. We studied workers in China occupationally exposed to benzene, trichloroethylene (TCE) or formaldehyde by measuring personal air exposures prior to blood collection. Unexposed controls matched by age and sex were selected from nearby factories. We measured leukocyte DNA methylation (DNAm) in peripheral white blood cells using the Infinium HumanMethylation450 BeadChip to calculate five epigenetic aging clocks and DNAmTL, a biomarker associated with leukocyte telomere length and cell replication. We tested associations between exposure intensity and epigenetic age acceleration (EAA), defined as the residuals of regressing the DNAm aging biomarker on chronological age, matching factors and potential confounders. Median differences in EAA between exposure groups were tested using a permutation test with exact p-values. Epigenetic clocks were strongly correlated with age (Spearman r > 0.8) in all three occupational studies. There was a positive exposure-response relationship between benzene and the Skin-Blood Clock EAA biomarker: median EAA was −0.91 years in controls (n = 44), 0.78 years in workers exposed to <10 ppm (n = 41; mean benzene = 1.35 ppm; p = 0.034 vs. controls), and 2.10 years in workers exposed to ≥10 ppm (n = 9; mean benzene = 27.3 ppm; p = 0.019 vs. controls; ptrend = 0.0021). In the TCE study, control workers had a median Skin-Blood Clock EAA of −0.54 years (n = 71) compared to 1.63 years among workers exposed to <10 ppm of TCE (n = 27; mean TCE = 4.22 ppm; p = 0.035). We observed no evidence of EAA associations with formaldehyde exposure (39 controls, 31 exposed). Occupational benzene and TCE exposure were associated with increased epigenetic age acceleration measured by the Skin-Blood Clock. For TCE, there was some e

Published
2022

180. Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde

Author

Sub Dynamics Meteorology, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Finance and Financial Markets, Social Urban Transitions, Sub Organic Chemistry and Catalysis, Sub SIM overig, van der Laan, L., Cardenas, A., Vermeulen, R., Fadadu, R.P., Hubbard, A.E., Phillips, R.V., Zhang, L., Breeze, C., Hu, W., Wen, C., Huang, Y., Tang, X., Smith, M.T., Rothman, N., Lan, Q., Sub Dynamics Meteorology, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Finance and Financial Markets, Social Urban Transitions, Sub Organic Chemistry and Catalysis, Sub SIM overig, van der Laan, L., Cardenas, A., Vermeulen, R., Fadadu, R.P., Hubbard, A.E., Phillips, R.V., Zhang, L., Breeze, C., Hu, W., Wen, C., Huang, Y., Tang, X., Smith, M.T., Rothman, N., and Lan, Q.

Published
2022

181. Psychosocial adjustment in adults with Duchenne muscular dystrophy: A pilot study on a shortened parent-report questionnaire

Author

Weerkamp, Pien M M, Weerkamp, Pien M M, Collin, Philippe, Maas, Rosa J, Vermeulen, R Jeroen, Klinkenberg, Sylvia, Hendriksen, Jos G M, Weerkamp, Pien M M, Weerkamp, Pien M M, Collin, Philippe, Maas, Rosa J, Vermeulen, R Jeroen, Klinkenberg, Sylvia, and Hendriksen, Jos G M

Abstract

The primary aim of this study was to describe the psychometric properties of an adult revision of the 28 item Personal Adjustment and Role Skills Scale (PARS-III). This scale was originally developed to assess psychosocial adjustment in children 4-18 years of age and has been applied in boys with Duchenne muscular dystrophy (DMD) and was found to be reliable and valid. Within the context of a longer lifespan in dystrophinopathies there is a growing need to assess psychosocial adjustment in an adult population. The original 28 items questionnaire was administered to parents of 90 adult men with DMD. The items of the PARS-III were rated by three experts, one parent, and one adult with DMD to indicate appropriateness of the items. For 22 items, there was consensus among the raters. Results of the Confirmatory Factor Analysis show an acceptable fit and closely resembles the original factor structure of the PARS-III, thereby justifying the use of the previously identified six subscales of psychosocial adjustment. In conclusion, the current 22 item PARS-Adult is a valuable, reliable, and valid screening of psychosocial adjustment in adult DMD patients. With this tool, continuity of assessment and follow up can be guaranteed in this clinical population.

Published
2022

182. Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Castaño-Vinyals, G, Sadetzki, S, Vermeulen, R, Momoli, F, Kundi, M, Merletti, F, Maslanyj, M, Calderon, C, Wiart, J, Lee, A-K, Taki, M, Sim, M, Armstrong, B, Benke, G, Schattner, R, Hutter, H-P, Krewski, D, Mohipp, C, Ritvo, P, Spinelli, J, Lacour, B, Remen, T, Radon, K, Weinmann, T, Petridou, E Th, Moschovi, M, Pourtsidis, A, Oikonomou, K, Kanavidis, P, Bouka, E, Dikshit, R, Nagrani, R, Chetrit, A, Bruchim, R, Maule, M, Migliore, E, Filippini, G, Miligi, L, Mattioli, S, Kojimahara, N, Yamaguchi, N, Ha, M, Choi, K, Kromhout, H, Goedhart, G, 't Mannetje, A, Eng, A, Langer, C E, Alguacil, J, Aragonés, N, Morales-Suárez-Varela, M, Badia, F, Albert, A, Carretero, G, Cardis, E, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Castaño-Vinyals, G, Sadetzki, S, Vermeulen, R, Momoli, F, Kundi, M, Merletti, F, Maslanyj, M, Calderon, C, Wiart, J, Lee, A-K, Taki, M, Sim, M, Armstrong, B, Benke, G, Schattner, R, Hutter, H-P, Krewski, D, Mohipp, C, Ritvo, P, Spinelli, J, Lacour, B, Remen, T, Radon, K, Weinmann, T, Petridou, E Th, Moschovi, M, Pourtsidis, A, Oikonomou, K, Kanavidis, P, Bouka, E, Dikshit, R, Nagrani, R, Chetrit, A, Bruchim, R, Maule, M, Migliore, E, Filippini, G, Miligi, L, Mattioli, S, Kojimahara, N, Yamaguchi, N, Ha, M, Choi, K, Kromhout, H, Goedhart, G, 't Mannetje, A, Eng, A, Langer, C E, Alguacil, J, Aragonés, N, Morales-Suárez-Varela, M, Badia, F, Albert, A, Carretero, G, and Cardis, E

Published
2022

184. Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Finance and Financial Markets, Social Urban Transitions, Sub Organic Chemistry and Catalysis, Sub SIM overig, Cardenas, A., Vermeulen, R., Fadadu, R.P., Hubbard, A.E., Phillips, R.V., Zhang, L., Breeze, C., Hu, W., Wen, C., Huang, Y., Tang, X., Smith, M.T., Rothman, N., Lan, Q., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Finance and Financial Markets, Social Urban Transitions, Sub Organic Chemistry and Catalysis, Sub SIM overig, Cardenas, A., Vermeulen, R., Fadadu, R.P., Hubbard, A.E., Phillips, R.V., Zhang, L., Breeze, C., Hu, W., Wen, C., Huang, Y., Tang, X., Smith, M.T., Rothman, N., and Lan, Q.

Published
2022

185. LongITools:dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Author

Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), Sebert, S. (Sylvain), Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), and Sebert, S. (Sylvain)

Abstract

The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our ”modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases.

Published
2022

186. Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Casey, K., Olen, O., Ludvigsson, J.F., Carbonnel, F., Oldenburg, B., Gunter, M.J., Tjønneland, A., Grip, O., Amian, P., Barricarte, A., Bergmann, M.M., Boutron-Ruault, M.-C., Cross, A., Hart, A.R., Kaaks, R., Key, T., Chirlaque López, M.D., Luben, Robert, Masala, G., Manjer, J., Olsen, A., Overvad, K., Palli, D., Riboli, E., Sánchez, M.J., Tumino, R., Vermeulen, R., Verschuren, W.M.M., Wareham, N., Ananthakrishnan, A., Burke, K., Lopes, E.W., Lochhead, P., Chan, A.T., Wolk, A., Khalili, H., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Casey, K., Olen, O., Ludvigsson, J.F., Carbonnel, F., Oldenburg, B., Gunter, M.J., Tjønneland, A., Grip, O., Amian, P., Barricarte, A., Bergmann, M.M., Boutron-Ruault, M.-C., Cross, A., Hart, A.R., Kaaks, R., Key, T., Chirlaque López, M.D., Luben, Robert, Masala, G., Manjer, J., Olsen, A., Overvad, K., Palli, D., Riboli, E., Sánchez, M.J., Tumino, R., Vermeulen, R., Verschuren, W.M.M., Wareham, N., Ananthakrishnan, A., Burke, K., Lopes, E.W., Lochhead, P., Chan, A.T., Wolk, A., and Khalili, H.

Published
2022

187. Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach

Author

Ottenbros, I., Lebret, E., Huber, Carolin Elisabeth, Lommen, A., Antignac, J.-P., Čupr, P., Šulc, L., Mikeš, O., Szigeti, T., Középesy, S., Martinsone, I., Martinsone, Z., Akulova, L., Pardo, O., Fernández, S.F., Coscollá, C., Pedraza-Diaz, S., Krauss, Martin, Debrauwer, L., Wagner, K., Nijssen, R., Mol, H., Vitale, C.M., Klanova, J., Garlito Molina, B., León, N., Vermeulen, R., Luijten, M., Vlaanderen, J., Ottenbros, I., Lebret, E., Huber, Carolin Elisabeth, Lommen, A., Antignac, J.-P., Čupr, P., Šulc, L., Mikeš, O., Szigeti, T., Középesy, S., Martinsone, I., Martinsone, Z., Akulova, L., Pardo, O., Fernández, S.F., Coscollá, C., Pedraza-Diaz, S., Krauss, Martin, Debrauwer, L., Wagner, K., Nijssen, R., Mol, H., Vitale, C.M., Klanova, J., Garlito Molina, B., León, N., Vermeulen, R., Luijten, M., and Vlaanderen, J.

Abstract

Humans are exposed to a mixture of pesticides through diet as well as through the environment. We conducted a suspect-screening based study to describe the probability of (concomitant) exposure to a set of pesticide profiles in five European countries (Latvia, Hungary, Czech Republic, Spain and the Netherlands). We explored whether living in an agricultural area (compared to living in a peri-urban area), being a a child (compared to being an adult), and the season in which the urine sample was collected had an impact on the probability of detection of pesticides (-metabolites).In total 2088 urine samples were collected from 1050 participants (525 parent-child pairs) and analyzed through harmonized suspect screening by five different laboratories. Fourty pesticide biomarkers (either pesticide metabolites or the parent pesticides as such) relating to 29 pesticides were identified at high levels of confidence in samples across all study sites. Most frequently detected were biomarkers related to the parent pesticides acetamiprid and chlorpropham. Other biomarkers with high detection rates in at least four countries related to the parent pesticides boscalid, fludioxonil, pirimiphos-methyl, pyrimethanil, clothianidin, fluazifop and propamocarb. In 84% of the samples at least two different pesticides were detected. The median number of detected pesticides in the urine samples was 3, and the maximum was 13 pesticides detected in a single sample. The most frequently co-occurring substances were acetamiprid with chlorpropham (in 62 urine samples), and acetamiprid with tebuconazole (30 samples). Some variation in the probability of detection of pesticides (-metabolites) was observed with living in an agricultural area or season of urine sampling, though no consistent patterns were observed. We did observe differences in the probability of detection of a pesticide (metabolite) among children compared to adults, suggesting a different exposure and/or elimination patterns between

Published
2022

188. A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences

Author

Huber, Carolin Elisabeth, Nijssen, R., Mol, H., Antignac, J.P., Krauss, Martin, Brack, Werner, Wagner, K., Debrauwer, L., Vitale, C.M., Price, E.J., Klanova, J., Garlito Molina, B., Leon, N., Pardo, O., Fernández, S.F., Szigeti, T., Középesy, S., Šulc, L., Čupr, P., Mārtiņsone, I., Akülova, L., Ottenbros, I., Vermeulen, R., Vlaanderen, J., Luijten, M., Lommen, A., Huber, Carolin Elisabeth, Nijssen, R., Mol, H., Antignac, J.P., Krauss, Martin, Brack, Werner, Wagner, K., Debrauwer, L., Vitale, C.M., Price, E.J., Klanova, J., Garlito Molina, B., Leon, N., Pardo, O., Fernández, S.F., Szigeti, T., Középesy, S., Šulc, L., Čupr, P., Mārtiņsone, I., Akülova, L., Ottenbros, I., Vermeulen, R., Vlaanderen, J., Luijten, M., and Lommen, A.

Abstract

Within the Human Biomonitoring for Europe initiative (HBM4EU), a study to determine new biomarkers of exposure to pesticides and to assess exposure patterns was conducted. Human urine samples (N=2,088) were collected from five European regions in two different seasons. The objective of the study was to identify pesticides and their metabolites in collected urine samples with a harmonized suspect screening approach based on liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) applied in five laboratories. A combined data processing workflow included comprehensive data reduction, correction of mass error and retention time (RT) drifts, isotopic pattern analysis, adduct and elemental composition annotation, finalized by a mining of the elemental compositions for possible annotations of pesticide metabolites. The obtained tentative annotations (n=498) were used for acquiring representative data-dependent tandem mass spectra (MS2) and verified by spectral comparison to reference spectra generated from commercially available reference standards or produced through human liver S9 in-vitro incubation experiments. 14 parent pesticides and 71 metabolites (including 16 glucuronide and 11 sulfate conjugates) were detected. Collectively these related to 46 unique pesticides.For the remaining tentative annotations either (i) no data-dependent MS2 spectra could be acquired, (ii) the spectral purity was too low for sufficient matching, or (iii) RTs indicated a wrong annotation, leaving potential for more pesticides and/or their metabolites being confirmed in further studies. Thus, the reported results are reflecting only a part of the possible pesticide exposure.

Published
2022

189. Proefveld bomen planten Nabbegat Zeeland

Author

Vermeulen, R. and Vermeulen, R.

Abstract

In maart 2021 is een proefveld aangelegd om te onderzoeken welke manier van planten de bomen weerbaarder maakt in het veranderde klimaat.

Published
2022

190. Clinical Utility of Eye Tracking in Assessing Distractibility in Children with Neurological Disorders or ADHD:A Cross-Sectional Study

Author

Sweere, Dirk J.J., Pel, Johan J.M., Kooiker, Marlou J.G., van Dijk, Johannes P., van Gemert, Elizabeth J.J.M., Hurks, Petra P.M., Klinkenberg, Sylvia, Vermeulen, R. Jeroen, Hendriksen, Jos G.M., Sweere, Dirk J.J., Pel, Johan J.M., Kooiker, Marlou J.G., van Dijk, Johannes P., van Gemert, Elizabeth J.J.M., Hurks, Petra P.M., Klinkenberg, Sylvia, Vermeulen, R. Jeroen, and Hendriksen, Jos G.M.

Abstract

This study aims to investigate distractibility quantified by recording and analyzing eye movements during task-irrelevant distraction in children with and without ADHD and in children with and without neurological disorders. Gaze behavior data and press latencies of 141 participants aged 6–17 that were collected during a computerized distraction paradigm with task-irrelevant stimuli (IDistrack) were analyzed. Children using attention-regulating medication were excluded from participation. Data were analyzed for subgroups that were formed based on the presence of neurological disorders and the presence of ADHD separately. Participants with ADHD and participants with neurological disorders spent less time fixating on the target stimuli compared to their peers without ADHD (p = 0.025) or their peers without neurological disorders (p < 0.001). Participants with and without ADHD had equal press latencies (p = 0.79). Participants with neurological disorders had a greater press latency compared to their typically developing peers (p < 0.001). Target fixation duration shows a significant association with parent-reported attention problems (r = −0.39, p < 0.001). We conclude that eye tracking during a distraction task reveals potentially valid clinical information that may contribute to the assessment of dysfunctional attentional processes. Further research on the validity and reliability of this paradigm is recommended.

Published
2022

191. Environmental factors shaping the gut microbiome in a Dutch population

Author

Cancer, Global Health, Child Health, Planetary Health & Exposoom, Circulatory Health, Gacesa, R, Kurilshikov, A, Vich Vila, A, Sinha, T, Klaassen, M A Y, Bolte, L A, Andreu-Sánchez, S, Chen, L, Collij, V, Hu, S, Dekens, J A M, Lenters, V C, Björk, J R, Swarte, J C, Swertz, M A, Jansen, B H, Gelderloos-Arends, J, Jankipersadsing, S, Hofker, M, Vermeulen, R C H, Sanna, S, Harmsen, H J M, Wijmenga, C, Fu, J, Zhernakova, A, Weersma, R K, Cancer, Global Health, Child Health, Planetary Health & Exposoom, Circulatory Health, Gacesa, R, Kurilshikov, A, Vich Vila, A, Sinha, T, Klaassen, M A Y, Bolte, L A, Andreu-Sánchez, S, Chen, L, Collij, V, Hu, S, Dekens, J A M, Lenters, V C, Björk, J R, Swarte, J C, Swertz, M A, Jansen, B H, Gelderloos-Arends, J, Jankipersadsing, S, Hofker, M, Vermeulen, R C H, Sanna, S, Harmsen, H J M, Wijmenga, C, Fu, J, Zhernakova, A, and Weersma, R K

Published
2022

193. Determinants of spoken language comprehension in children with cerebral palsy.

Author

Vaillant, Emma, Geytenbeek, Johanna J. M., Oostrom, Kim J., Beckerman, Heleen, Vermeulen, R. Jeroen, and Buizer, Annemieke I.

Subjects
STATISTICS, PHYSIOLOGICAL aspects of speech, CROSS-sectional method, MULTIVARIATE analysis, REGRESSION analysis, COGNITION, CONCEPTUAL structures, PEARSON correlation (Statistics), QUESTIONNAIRES, QUALITY of life, DESCRIPTIVE statistics, CEREBRAL palsy, DATA analysis, DATA analysis software, MOTOR ability, LONGITUDINAL method
Abstract

To identify determinants of spoken language comprehension (SLC) in children with cerebral palsy (CP). Cross-sectional data of 207 children with CP were included: 82 toddlers (18 months–3;11 years), 59 preschool children (4;0–5;11 years), and 66 schoolchildren (6;0–8;11 years), across all Gross Motor Function Classification System (GMFCS) levels. SLC was assessed using the Computer-Based instrument for Low motor Language Testing (C-BiLLT). Potential determinants were retrieved from medical files and through parental questionnaires. Per developmental stage, multivariable regression analyses were used to assess determinants of SLC. Fifty-nine percent of the children showed below average SLC. Significant determinants for SLC differed per developmental stage. In toddlers: age, motor type, functional communication and speech function (R2 = 0.637); in preschool children: functional communication, speech function and language activities (R2 = 0.820), and in schoolchildren: functional communication, intellectual functioning and arm-hand functioning (R2 = 0.807). For all developmental stages, functional mobility was not a significant determinant. A large proportion of children with CP across all GMFCS levels have SLC impairments. Findings indicate that SLC is strongly determined by functional communication classified with CFCS. We recommend standardized assessment and monitoring of SLC in all children with CP. Children across all GMFCS levels can experience difficulties in spoken language comprehension. At all developmental stages, functional communication (classified with CFCS) is an important determinant of spoken language comprehension. Standardized assessment and monitoring of spoken language comprehension, language production, speech, and communication of all children with CP, is strongly recommended. When children show below average performances, especially in spoken language comprehension, intervening with speech and language therapy and guidance for parents, is advised. [ABSTRACT FROM AUTHOR]

Published
2023
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195. Attainment of personal goals in the first year of intrathecal baclofen treatment in dyskinetic cerebral palsy: a prospective cohort study.

Author

Bonouvrié, Laura A., Haberfehlner, Helga, Becher, Jules G., Vles, Johan S. H., Vermeulen, R. Jeroen, and Buizer, Annemieke I.

Subjects
RESEARCH, KRUSKAL-Wallis Test, SPINAL infusions, PAIN measurement, DRUG infusion pumps, TREATMENT effectiveness, BACLOFEN, RESEARCH funding, DESCRIPTIVE statistics, QUESTIONNAIRES, CEREBRAL palsy, DATA analysis software, GOAL (Psychology), LONGITUDINAL method
Abstract

To assess attainment of individual treatment goals one year after intrathecal baclofen (ITB) pump implantation in individuals with dyskinetic cerebral palsy (CP). A multi-center prospective cohort study was conducted including 34 non-walking individuals with severe dyskinetic CP, classified as Gross Motor Function Classification System (GMFCS) IV/V, aged 4–24 years, 12 months after pump implantation. The main outcome measure was Goal Attainment Scaling (GAS). Predictors of GAS results were analyzed. Complications were registered systematically. Seventy-one percent of individuals with dyskinetic CP fully achieved one or more treatment goals. One or more treatment goals were partially achieved in 97% of individuals. Two factors were found to be associated with attainment of goals: Dyskinesia Impairment Scale (DIS) score at baseline and the difference in pain score between baseline and follow-up. These two variables explain 30% of the variance in the outcome. Intrathecal baclofen is effective in achieving individual treatment goals in children and young adults with dyskinetic CP after nine to 12 months of ITB treatment. A positive outcome on treatment goals is, for a small part, associated with higher severity of dystonia at baseline and with improvement of pain during treatment. Dutch Trial Register, number NTR3642. Intrathecal baclofen treatment is effective in attainment of personal treatment goals, one year after pump implantation in patients with dyskinetic cerebral palsy. A positive outcome on treatment goals is, for a small part, related to higher severity of dystonia at the start and on improvement of pain during treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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199. Occupation and risk of lymphoma: a multicentre prospective cohort study (EPIC)

Author

Neasham, David, Sifi, Ahlem, Nielsen, Kaspar Rene, Overvad, Kim, Raaschou-Nielsen, Ole, Tjønneland, Anne, Barricarte, Aurelio, González, Carlos A, Navarro, Carmen, Suarez, Laudina Rodriguez, Travis, Ruth C, Key, Tim, Linseisen, Jakob, Kaaks, Rudolf, Crosignani, Paolo, Berrino, Franco, Rosso, Stefano, Mattiello, Amalia, Vermeulen, R C H, Bueno-de-Mesquita, H Bas, Berglund, Göran, Manjer, Jonas, Zackrisson, Sophia, Hallmans, Goran, Malmer, Beatrice, Bingham, Sheila, Khaw, Kay Tee, Bergmann, Manuela M, Boeing, Heiner, Trichopoulou, Antonia, Masala, Giovanna, Tumino, Rosario, Lund, Eiliv, Slimani, Nadia, Ferrari, Pietro, Boffetta, Paolo, Vineis, Paolo, and Riboli, Elio

Published
2011

200. Deep phenotyping meets big data

Author

Lakerveld, J., Wagtendonk, A., Vaartjes, I., Karssenberg, D., Penninx, B., Beulens, J., Timmermans, E., Huisman, M., Kramer, S., van Wier, M., Boomsma, D., Willemsen, G., Schuengel, C., Oosterman, M., Stronks, K., Vermeulen, R., Koster, A., Stehouwer, C., van den Hurk, K., Koomen, E., de Mutsert, R., Have, M., Verschuren, M., Picavet, S., Beenackers, M., van Lenthe, F., Ikram, A., Jaddoe, V., Oldehinkel, T., de Jong, T., Mulder, S., Dotinga, A., Landdegradatie en aardobservatie, Landscape functioning, Geocomputation and Hydrology, Organizational Culture and Change, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Afd Pharmacology, Urban Accessibility and Social Inclusion, Geography and Education, Leerstoel Aken, UU LEG Research USG Public Matters, Spatial Economics, Sociology, The Social Context of Aging (SoCA), Biological Psychology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Health Behaviors & Chronic Diseases, Clinical Child and Family Studies, LEARN! - Child rearing, APH - Aging & Later Life, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Sociale Geneeskunde, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Endocrinologie (9), MUMC+: HVC Pieken Maastricht Studie (9), Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), Public Health, Epidemiology, Erasmus MC other, Pediatrics, Epidemiology and Data Science, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, APH - Societal Participation & Health, Otolaryngology / Head & Neck Surgery, APH - Quality of Care, APH - Digital Health, and Public and occupational health

Subjects
Earth science, Big data, 010501 environmental sciences, 01 natural sciences, Health informatics, DISEASE, Environmental data, Data science, Cohort Studies, 0302 clinical medicine, 030212 general & internal medicine, Netherlands, ASSOCIATIONS, Non-communicabledisease, Environmental exposure, Non-communicable disease, SDG 11 - Sustainable Cities and Communities, Exposome, Geography, Cohort, lcsh:R858-859.7, BURDEN, medicine.medical_specialty, General Computer Science, Health geography, GREEN, Environment, lcsh:Computer applications to medicine. Medical informatics, Exposure, 03 medical and health sciences, REGRESSION, medicine, Humans, 0105 earth and related environmental sciences, business.industry, Research, Public health, Prevention, Public Health, Environmental and Occupational Health, Environmental Exposure, AIR-POLLUTION, General Business, Management and Accounting, Earth Sciences, Upstream determinants, business, Cohorts, ENVIRONMENTS
Abstract

Environmental exposures are increasingly investigated as possible drivers of health behaviours and disease outcomes. So-called exposome studies that aim to identify and better understand the effects of exposures on behaviours and disease risk across the life course require high-quality environmental exposure data. The Netherlands has a great variety of environmental data available, including high spatial and often temporal resolution information on urban infrastructure, physico-chemical exposures, presence and availability of community services, and others. Until recently, these environmental data were scattered and measured at varying spatial scales, impeding linkage to individual-level (cohort) data as they were not operationalised as personal exposures, that is, the exposure to a certain environmental characteristic specific for a person. Within the Geoscience and hEalth Cohort COnsortium (GECCO) and with support of the Global Geo Health Data Center (GGHDC), a platform has been set up in The Netherlands where environmental variables are centralised, operationalised as personal exposures, and used to enrich 23 cohort studies and provided to researchers upon request. We here present and detail a series of personal exposure data sets that are available within GECCO to date, covering personal exposures of all residents of The Netherlands (currently about 17 M) over the full land surface of the country, and discuss challenges and opportunities for its use now and in the near future.

Published
2020
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