151. Interleukin-31: a new cytokine involved in inflammation of the skin
- Author
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Jacopo Vecchiet, Donelan J, Stavros Frydas, Stefano Tetè, Claudia Petrarca, Katia Falasca, B. Madhappan, Vincenzo Salini, Giampiero Neri, M.L. Castellani, Castellani, Ml, Salini, V, Frydas, S, Donelan, J, Madhappan, B, Petrarca, C, J., Vecchiet, Falasca, K, Neri, G, and Tete, S
- Subjects
Pharmacology ,business.industry ,medicine.medical_treatment ,Interleukins ,education ,Immunology ,Inflammation ,Dermatitis ,T cell response ,humanities ,03 medical and health sciences ,0302 clinical medicine ,Interleukin 31 ,Cytokine ,030220 oncology & carcinogenesis ,medicine ,Immunology and Allergy ,Humans ,medicine.symptom ,business ,030215 immunology ,Skin - Abstract
Cytokines affect immune functions involved inmotility, chemotaxis, phagocytosis, cytotoxicityand antigen presentation (1). Interleukins (IL) arepleiotropic cytokines with diverse receptorsignaling pathways whose expression is controlledat multiple levels (2). Interleukin receptors (ILR)have intrinsic roles in regulating and amplifyingthe inflammatory response (3-12).Skin is the largest organ of the body with thespecific immune defense and its inflammatoryconditions include atopic dermatitis, allergies,psoriasis etc. (13-19). Infiltrated lymphocytesproliferate in an activated state in the skin lesion inan autocrine and/or paracrine manner and produceTH2-type cytokines that might evoke immunologicabnormalities (20-23)....
- Published
- 2006