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Traditionally, we expect that circuit designs can be executed without errors. However, for error resilient applications such as image processing, 100% correctness is not necessary. By pursuing less than 100% correctness, power consumption can be significantly reduced. Recently, probabilistic CMOS and probabilistic Boolean circuits (PBCs) have been proposed to deal with power consumption issue. However, to the best of our knowledge, no correctness analysis and power optimization algorithms have been proposed for PBCs. Thus, in this paper, we first propose a statistical approach for evaluating the correctness of PBCs. Then, we propose strategies for power optimization of PBCs. Finally, we integrate these strategies with the correctness analysis as a power optimization algorithm for PBCs. The experimental results show that the proposed correctness analysis method is highly efficient and accurate, and that the power optimization algorithm saves 36% of total power-delay-product on average under a correctness constraint of 90% on a set of International Workshop on Logic and Synthesis (IWLS) 2005 benchmarks. [ABSTRACT FROM PUBLISHER]

The article offers information on the study which investigates the morphological and ultrastructural characterization of hair follicle of Yuyi curly rats.

Superpixel can capture redundancy of the image and reduce the complexity of subsequent processing tasks. These advantages make it receive more and more attentions from researchers at home and abroad. This paper first analyzed the development of the superpixel segmentation, and summarized the state-of-the-art superpixel segmentation algorithms in the view of graph-based and gradient-ascent-based methods. Then, it compared several superpixel segmentation algorithms by experiments, and illustrated their strengths and weaknesses respectively. At last, it introduced the latest applications of superpixel segmentation techniques with prospects. [ABSTRACT FROM AUTHOR]

The article focuses on a study related to the molecular cloning of complementary DNA (cDNA) sequences which encode the epidermal growth factor (EGF) in Sprague Dawley (SD) rats. Topics discussed include the significance of polymerase chain reaction for cloning, use of the basic local alignment search tool program to determine single nucleotide polymorphism sites, and comparison of identities of cDNA sequences of EGF genes in SD rats with other species.

The article presents a study which examines the breeding and biological characteristics of a curly-haired mutation inbred strain rat.

Reducing the number of AND gates in logic networks benefits the applications in cryptography, security, and quantum computing. This work proposes a don’t-care-based (DC-based) approach to reduce the number of AND gates further in the well-optimized network. Furthermore, this work also proposes an enhanced synthesis flow by integrating our approach with the state-of-the-art. The experimental results show that our approach can further reduce up to 25% of the number of AND gates in the network. For the experiments about the enhanced synthesis flow, we achieve a speedup of almost $10\times $ on average for the cryptography benchmarks while having competitive results as compared to the flow in the state-of-the-art. [ABSTRACT FROM AUTHOR]

In this work, the feasibility of liquid level detection based on structural vibration modes is investigated. We specifically consider impact-induced vibration modes of an aluminum solid partially immersed in a water tank. A free-edge bonded fiber Bragg grating (FBG) sensor and a corresponding high-speed FBG filter-based demodulation system are employed to measure the transient impact responses. To perform more accurate in vacuo finite element analysis (i.e., for the mode shapes, resonant frequencies, and the impact responses), elastic constants of the aluminum solid and impact loading history of a steel ball are obtained beforehand respectively according to the elastic wave theory and with a polyvinylidene fluoride (PVDF)-based technique. Our experimental results show good correspondences of intensities and shifts of the impact-induced resonant modes with liquid levels. The modes of the same type (e.g., double modes in out-of-plane or in-plane dominated modes) are shown to possess similar behaviors in relationships between shifts of the resonant modes and the liquid level. This work also provides related experimental evidence for future researchers interesting in simulation of complicated fluid-structure interaction (FSI) problems for three-dimensional structures. [ABSTRACT FROM AUTHOR]

Threshold logic has been attracting great attention from researchers due to the rapid development in nanotechnology-based devices. In the state-of-the-art approach to the threshold logic network (TLN) synthesis using don’t cares, we observed that not all the computed don’t cares contribute to the cost minimization of threshold logic gate (TLG). Therefore, in this work, we focus on computing the don’t cares that effectively provide the opportunities for cost minimization. Furthermore, De Morgan’s law for TLGs is applied such that global TLN optimization considering the cost and the number of inverters can be achieved. The experimental results show that the proposed approach is capable of obtaining efficiently a smaller cost and fewer inverters for a set of TLN benchmarks. [ABSTRACT FROM AUTHOR]

Quantum-dot cellular automata (QCA) is considered as a promising emerging technology due to its low power dissipation and high device density. Since the majority function is the main operation in QCA circuits, minimizing the number of majority gates in QCA circuits is crucial to the corresponding QCA circuit minimization. A previous work used the node-merging technique to replace one target node with an existing substitute node in majority circuits for optimization. However, this technique may fail when no substitute nodes exist for a target node. In this article, we propose an enhanced optimization technique for majority circuits by adding a new node into the circuits and removing the target node and its fanin nodes. The experimental results show that this technique improves the results of the node-merging technique on a set of EPFL logic synthesis benchmarks. Additionally, this enhanced technique can work together with other optimization techniques. The circuit size reduction in the integrated approach reaches 1.26 times as compared to the results using the node-merging technique. [ABSTRACT FROM AUTHOR]

LOOPLock is the state-of-the-art cyclic logic locking method in hardware security. LOOPLock is able to invalidate SAT Attack, Removal Attack, and CycSAT simultaneously by introducing two types of cycle pairs in a circuit. In this work, we analyze LOOPLock’s locking mechanism and propose an attacking approach based on locking structure analysis. Furthermore, to defend the new attack, we propose LOOPLock 2.0, which strengthens the original cyclic logic locking method—LOOPLock. Experimental results show the efficiency and effectiveness of the proposed attacking approach to LOOPLock and the high defense capability of LOOPLock 2.0. [ABSTRACT FROM AUTHOR]

Abstract: As the first step of DRAM manufacture, preanneal process plays an important role in determining the threshold voltage variation. It is found that the higher trans-1,2-dichloroethene flow in pad oxide growth and the higher nitrogen flow in high-temperature annealing step would respectively engender a lower boron segregation coefficient and higher nitridation of the oxide, both modify the boron distribution in the substrate and consequently the behavior of the threshold voltage. As the feature size of DRAM devices enter nanometer regime, besides gate oxidation, ion implantation and related thermal processes, the impact of preanneal process condition should be prudentially taken into consideration for rigorous control of the threshold voltage in the advanced DRAM production. [Copyright &y& Elsevier]

This article proposes a new necessary condition and the corresponding speedup strategies to the threshold function (TF) identification problem. The state-of-the-art to this identification problem could be very time-consuming when the function-under-identification is a non-TF with the unateness property. The proposed new necessary condition can be seamlessly integrated into this identification algorithm. As compared with the state-of-the-art, the improved identification algorithm with the proposed necessary condition can more effectively and efficiently detect non-TFs. Furthermore, according to the experimental results, the ratio of CPU time overhead in the process of checking the proposed necessary condition for identifying all the 8-input TF is only 0.1%. [ABSTRACT FROM AUTHOR]

Objective: The etiologies of acute respiratory failure in patients with systemic rheumatic diseases (SRDs) requiring intensive care remain unknown. This study was undertaken to investigate the etiologies and outcomes. Methods: A medical records review study was performed of 259 adult SRDs patients with respiratory failure admitted to medical ICU across a 5-year period. The etiologies were classified as infection, SRD exacerbation, and undetermined. The factors associated with ICU mortality were identified with multivariate logistic regression analysis. Results: The etiologies of respiratory failure included infection (n = 209, 80.7%), SRD exacerbation (n = 71, 27.4%), and undetermined (n = 21, 8.1%). The most common pathogen was Pneumocystis jirovecii (39.8%), followed by Aspergillus spp. (33.2%), and cytomegalovirus (23.2%). The ICU mortality rate was 59.8%. A high acute physiology and chronic health evaluation II score (OR 1.118, 95% CI 1.054 to 1.186, p < 0.001), a PaO2/FiO2 ratio < 100 mmHg (OR 3.918, 95% CI 2.199 to 6.892, p < 0.001), and a diagnosis of dermatomyositis/polymyositis (OR 4.898, 95% CI 1.949 to 12.309, p = 0.001), vasculitis (OR 3.007, 95% CI 1.237 to 7.309, p = 0.015), and Pneumocystis pneumonia (OR 2.345, 95% CI 1.168 to 4.705, p = 0.016) were associated with increased mortality. Conclusions: Opportunistic infections and SRD exacerbation were the most common etiologies of acute respiratory failure in patients with SRDs requiring ICU admission, with high ICU mortality. Development of a standard protocol for differential diagnosis in this population might help initiate definitive therapy and improve clinical outcome. Key Points • Infections, especially with opportunistic infections, were the leading cause of acute respiratory failure in critically ill rheumatology patients, with high mortality. • Severity of illness, certain types of rheumatic diseases, and opportunistic fungal infections were associated with increased mortality. • Using a comprehensive diagnostic workup might help to confirm the infective etiology and improve outcome. [ABSTRACT FROM AUTHOR]

SAT Attack, CycSAT, and Removal Attack have demonstrated their abilities to break most existing logic locking methods. In this article, we propose a new cyclic logic locking method to invalidate these attacks simultaneously. Our main intention is to create noncombinational cycles to lock a circuit. Specifically, the noncombinational behavior in the noncombinational cycles that is unobservable at the primary outputs (POs) needs to be preserved when the correct key-vector is fed to resist CycSAT, and the noncombinational behavior in the noncombinational cycles affecting POs needs to be preserved when the incorrect key-vector is fed to invalidate SAT Attack. Furthermore, some nodes will be removed when applying our locking method, which is able to defend Removal Attack. The experimental results show the effectiveness and low area overhead of the proposed method. [ABSTRACT FROM AUTHOR]

The identification of threshold function (TF), which determines whether a Boolean function can be represented by an linear threshold logic gate (LTG) or not, is a fundamental but important task in the theories of threshold logic. In this paper, we propose a more efficient and effective algorithm of TF identification by constructing the system of irredundant inequalities and adjusting the weight assignment comprehensively. This is the first non-ILP-based approach that is able to identify all the eight-input TFs. The experimental results demonstrated that the proposed approach is more effective than all the existing non-ILP-based approaches and the LTGs obtained by the proposed approach are optimal for near 100% cases. For TFs with 9–15 inputs, the proposed approach can identify 100 000 randomly generated TFs as well in a reasonable CPU time. [ABSTRACT FROM AUTHOR]

Purpose: A population-level description and analysis of sepsis-related mortality in China is key to the planning and assessment of interventional strategies.Methods: Retrospective analysis of multiple cause of death (MCOD) recorded in the population-based national mortality surveillance system (NMSS) of China. All sepsis-related deaths occurring in 605 disease surveillance points (DSPs) covering 323.8 million population across China were included in our study. Age-standardized mortality and national estimate of sepsis-related deaths were estimated using the census population in 2010 and 2015, respectively.Results: In 2015, a total of 1,937,299 deaths occurring in any of the 605 DSPs and standardized sepsis-related mortality rate was 66.7 (95% confidence interval [CI] 66.4-67.0) deaths per 100,000 population. This produced a national estimate of 1,025,997 sepsis-related deaths. Sepsis-related mortality rates exhibited significant geographic variation. In multilevel analysis, male sex (rate ratio [RR] 1.582, 95% CI 1.570-1.595), increasing age (RR 1.914 for 5-year group, 95% CI 1.910-1.917), and presence of comorbidity (RR 2.316, 95% CI 2.298-2.335) were independently associated with increased sepsis-related mortality. Higher disposable income (RR 0.717 for the fourth interquartile range vs. the first interquartile range, 95% CI 0.515-0.978) and mean years of education (RR 0.808 for the fourth interquartile range vs. the first interquartile range, 95% CI 0.684-0.955) were negatively associated with sepsis-related mortality. However, population-based hospital doctors were not significantly associated with sepsis-related mortality.Conclusions: The standardized sepsis-related mortality rate in China was high and varied according to socioeconomic indices, even though some uncertainty remained. [ABSTRACT FROM AUTHOR]

Background: Out-of-hospital cardiac arrest (OHCA) remains a significant cause of mortality and morbidity worldwide. Extracorporeal cardiopulmonary resuscitation (ECPR) is a potential intervention for OHCA, but its effectiveness compared to conventional cardiopulmonary resuscitation (CCPR) needs further evaluation., Method: We systematically searched PubMed, Embase, the Cochrane Library, Web of Science, and ClinicalTrials.gov for relevant studies from January 2010 to March 2023. Pooled meta-analysis was performed to investigate any potential association between ECPR and improved survival and neurological outcomes., Results: This systematic review and meta-analysis included two randomized controlled trials enrolling 162 participants and 10 observational cohort studies enrolling 4507 participants. The pooled meta-analysis demonstrated that compared to CCRP, ECPR did not improve survival and neurological outcomes at 180 days following OHCA (RR: 3.39, 95% CI: 0.79 to 14.64; RR: 2.35, 95% CI: 0.97 to 5.67). While a beneficial effect of ECPR was obtained regarding 30-day survival and neurological outcomes. Furthermore, ECPR was associated with a higher risk of bleeding complications. Subgroup analysis showed that ECPR was prominently beneficial when exclusively initiated in the emergency department. Additional post-resuscitation treatments did not significantly impact the efficacy of ECPR on 180-day survival with favorable neurological outcomes., Conclusions: There is no high-quality evidence supporting the superiority of ECPR over CCPR in terms of survival and neurological outcomes in OHCA patients. However, due to the potential for bias, heterogeneity among studies, and inconsistency in practice, the non-significant results do not preclude the potential benefits of ECPR. Further high-quality research is warranted to optimize ECPR practice and provide more generalizable evidence. Clinical trial registration PROSPERO, https://www.crd.york.ac.uk/prospero/, registry number: CRD42023402211., Competing Interests: Declaration of competing interest The authors report no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Purpose: Assessing fluid responsiveness relying on central venous oxygen saturation (ScvO 2 ) yields varied outcomes across several studies. This study aimed to determine the ability of the change in ScvO 2 (ΔScvO 2 ) to detect fluid responsiveness in ventilated septic shock patients and potential influencing factors., Methods: In this prospective, single-center study, all patients conducted from February 2023 to January 2024 received fluid challenge. Oxygen consumption was measured by indirect calorimetry, and fluid responsiveness was defined as an increase of cardiac index (CI) ≥ 10% measured by transthoracic echocardiography. Multivariate linear regression analysis was conducted to evaluate the impact of oxygen consumption, arterial oxygen saturation, CI, and hemoglobin on ScvO 2 and its change before and after fluid challenge., Results: Among 49 patients (31 men, aged (59 ± 18) years), 27 were responders. The patients had an acute physiology and chronic health evaluation II score of 24 ± 8, a sequential organ failure assessment score of 11 ± 4, and a blood lactate level of (3.2 ± 3.1) mmol/L at enrollment. After the fluid challenge, the ΔScvO 2 (mmHg) in the responders was greater than that in the non-responders (4 ± 6 vs. 1 ± 3, p = 0.019). Multivariate linear regression analysis suggested that CI was the only independent influencing factor of ScvO 2 , with R 2  = 0.063, p = 0.008. After the fluid challenge, the change in CI became the only contributing factor to ΔScvO 2 (R 2  = 0.245, p < 0.001). ΔScvO 2 had a good discriminatory ability for the responders and non-responders with a threshold of 4.4% (area under the curve = 0.732, p = 0.006)., Conclusion: ΔScvO 2 served as a reliable surrogate marker for ΔCI and could be utilized to assess fluid responsiveness, given that the change of CI was the sole contributing factor to the ΔScvO 2 . In stable hemoglobin conditions, the absolute value of ScvO 2 could serve as a monitoring indicator for adequate oxygen delivery independent of oxygen consumption., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2024 Chinese Medical Association. Production and hosting by Elsevier B.V. All rights reserved.)

Introduction: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients., Methods: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients. The relationship between immunosuppression and 30-day mortality after BSI onset was assessed through logistic-regression analysis, propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). Factors associated with mortality in immunosuppressed patients were analyzed using multivariable logistic regression analysis., Results: A total of 88 immunocompetent and 191 immunosuppressed patients were included, with 30-day all-cause mortality of 58.8%. Although the 30-day mortality in immunosuppressed patients was significantly higher than in immunocompetent patients (46.6% vs. 64.4%, P = 0.007), immunosuppression was not an independent risk factor for mortality in multivariate logistic regression analysis (odds ratio [OR] 3.53, 95% confidence interval [CI] 0.74-18.89; P = 0.123), PSM (OR 1.38, 95% CI 0.60-3.18; P = 0.449,) or IPTW (OR 1.40, 95% CI 0.58-3.36; P = 0.447). For patients with CRO-BSI, regardless of immune status, appropriate antibiotic therapy was associated with decreased 30-day mortality, while Charlson comorbidity index (CCI), intensive care unit (ICU)-acquired infection and thrombocytopenia at CRO-BSI onset were associated with increased mortality., Conclusion: Despite the high mortality rate of CRO-BSI, immunosuppression did not affect the mortality. Appropriate antibiotic therapy is crucial for improving the prognosis of CRO-BSI, regardless of the immune status., (© 2024. The Author(s).)

Purpose: To evaluate the safety, tolerability, pharmacokinetics, and efficacy of kukoamine B (KB), an alkaloid compound with high affinity for both lipopolysaccharide (LPS) and oligodeoxynucle-otides containing CpG motifs (CpG DNA), in patients with sepsis-induced organ failure., Materials and Methods: This was a multicenter, randomized, double-blind, placebo-controlled phase IIa trial. Patients with sepsis-induced organ failure were randomized to receive either KB (0.06, 0.12, or 0.24 mg/kg) or placebo, every 8 h for 7 days. Primary endpoint was safety, and secondary endpoints included pharmacokinetic (PK) parameters, changes in inflammatory mediators' level, and prognostic parameters., Results: Of 44 patients enrolled, adverse events occurred in 28 patients [n = 20, 66.7% (KB pooled); n = 8, 57.1% (placebo)], while treatment emergent adverse events were reported in 14 patients [n = 10, 33.3% (KB pooled); n = 4, 28.6% (placebo)]. Seven patients died at 28-day follow-up [n = 4, 13.3% (KB pooled); n = 3, 21.4% (placebo)], none was related to study drug. PK parameters suggested dose-dependent drug exposure and no drug accumulation. KB did not affect clinical outcomes such as ΔSOFA score, vasopressor-free days or ventilator-free days., Conclusions: In patients with sepsis-induced organ failure, KB was safe and well tolerated. Further investigation is warranted., Trial Registration: http://ClinicalTrials.gov, NCT03237728., Competing Interests: Declaration of Competing Interest All authors declare that they have no competing interests., (Copyright © 2023. Published by Elsevier Inc.)

Background: Tissue oxygen saturation (StO 2 ) decrease could appear earlier than lactate alteration. However, the correlation between StO 2 and lactate clearance was unknown., Methods: This was a prospective observational study. All consecutive patients with circulatory shock and lactate over 3 mmol/L were included. Based on the rule of nines, a BSA (body surface area) weighted StO 2 was calculated from four sites of StO 2 (masseter, deltoid, thenar and knee). The formulation was as follows: masseter StO 2  × 9% + (deltoid StO 2  + thenar StO 2 ) × (18% + 27%)/ 2 + knee StO 2  × 46%. Vital signs, blood lactate, arterial and central venous blood gas were measured simultaneously within 48 h of ICU admission. The predictive value of BSA-weighted StO 2 on 6-hour lactate clearance > 10% since StO 2 initially monitored was assessed., Results: A total of 34 patients were included, of whom 19 (55.9%) had a lactate clearance higher than 10%. The mean SOFA score was lower in cLac ≥ 10% group compared with cLac < 10% group (11 ± 3 vs. 15 ± 4, p = 0.007). Other baseline characteristics were comparable between groups. Compared to non-clearance group, StO 2 in deltoid, thenar and knee were significantly higher in clearance group. The area under the receiver operating curves (AUROC) of BSA-weighted StO 2 for prediction of lactate clearance (0.92, 95% CI [Confidence Interval] 0.82-1.00) was significantly higher than StO 2 of masseter (0.65, 95% CI 0.45-0.84; p < 0.01), deltoid (0.77, 95% CI 0.60-0.94; p = 0.04), thenar (0.72, 95% CI 0.55-0.90; p = 0.01), and similar to knee (0.87, 0.73-1.00; p = 0.40), mean StO 2 (0.85, 0.73-0.98; p = 0.09). Additionally, BSA-weighted StO 2 model had continuous net reclassification improvement (NRI) over the knee StO 2 and mean StO 2 model (continuous NRI 48.1% and 90.2%, respectively). The AUROC of BSA-weighted StO 2 was 0.91(95% CI 0.75-1.0) adjusted by mean arterial pressure and norepinephrine dose., Conclusions: Our results suggested that BSA-weighted StO 2 was a strong predictor of 6-hour lactate clearance in patients with shock., (© 2023. The Author(s).)

Background: Sepsis is a leading cause of preventable death around the world. Population-based estimation of sepsis incidence is lacking in China. In this study, we aimed to estimate the population-based incidence and geographic variation of hospitalized sepsis in China., Methods: We retrospectively identified hospitalized sepsis from the nationwide National Data Center for Medical Service (NDCMS) and the National Mortality Surveillance System (NMSS) by ICD-10 codes for the period from 2017 to 2019. In-hospital sepsis case fatality and mortality rate were calculated to extrapolate the national incidence of hospitalized sepsis. The geographic distribution of hospitalized sepsis incidence was examined using Global Moran's Index., Results: We identified 9,455,279 patients with 10,682,625 implicit-coded sepsis admissions in NDCMS and 806,728 sepsis-related deaths in NMSS. We estimated that the annual standardized incidence of hospitalized sepsis was 328.25 (95% CI 315.41-341.09), 359.26 (95% CI 345.4-373.12) and 421.85 (95% CI 406.65-437.05) cases per 100,000 in 2017, 2018 and 2019, respectively. We observed 8.7% of the incidences occurred among neonates less than 1 year old, 11.7% among children aged 1-9 years, and 57.5% among elderly older than 65 years. Significant spatial autocorrelation for incidence of hospitalized sepsis was observed across China (Moran's Index 0.42, p = 0.001; 0.45, p = 0.001; 0.26, p = 0.011 for 2017, 2018, 2019, respectively). Higher number of hospital bed supply and higher disposable income per capita were significantly associated with a higher incidence of hospitalized sepsis., Conclusion: Our study showed a greater burden of sepsis hospitalizations than previous estimated. The geographical disparities suggested more efforts were needed in prevention of sepsis., (© 2023. The Author(s).)

Acute respiratory distress syndrome (ARDS) is a common life-threatening clinical syndrome which accounts for 10% of intensive care unit admissions. Since the Berlin definition was developed, the clinical diagnosis and therapy have changed dramatically by adding a minimum positive end-expiratory pressure (PEEP) to the assessment of hypoxemia compared to the American-European Consensus Conference (AECC) definition in 1994. High-flow nasal cannulas (HFNC) have become widely used as an effective respiratory support for hypoxemia to the extent that their use was proposed in the expansion of the ARDS criteria. However, there would be problems if the diagnosis of a specific disease or clinical syndrome occurred, based on therapeutic strategies.

Growth-regulating factor (GRF) is a transcription factor unique to plants that plays a crucial role in the growth, development and stress adaptation of plants. However, information on the GRFs related to salt stress in Populus davidiana × P. bolleana is lacking. In this study, we characterized the activity of PdbGRF1 in transgenic Populus davidiana × P. bolleana under salt stress. qRTPCR analyses showed that PdbGRF1 was highly expressed in young leaves and that the pattern of PdbGRF1 expression was significantly changed at most time points under salt stress, which suggests that PdbGRF1 expression may be related to the salt stress response. Moreover, PdbGRF1 overexpression enhanced tolerance to salt stress. A physiological parameter analysis showed that the overexpression of PdbGRF1 significantly decreased the contents of hydrogen peroxide (H 2 O 2 ) and malondialdehyde (MDA) and increased the activities of antioxidant enzymes (SOD and POD) and the proline content. A molecular analysis showed that PdbGRF1 regulated the expression of PdbPOD17 and PdbAKT1 by binding to the DRE ('A/GCCGAC') in their respective promoters. Together, our results demonstrate that the binding of PdbGRF1 to DRE regulates genes related to stress tolerance and activates the associated physiological pathways, and these effects increase the ROS scavenging ability, reduce the degree of damage to the plasma membrane and ultimately enhance the salt stress response in Populus davidiana × P. bolleana., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)