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We have prepared a type of magnetic mesoporous nanomaterial with aggregation-induced emission properties (Fe3O4@mSiO2@TPA@BA, hence abbr. FSTB) to detect and remove cyanide ions (CN−) under magnetic conditions. FSTB has a large specific surface area and improved fluorescence performance to identify CN−, and its superparamagnetic behavior plays an important role in removing CN−. The magnetic sensor FSTB shows excellent selectivity and anti-interference for the detection of CN− in aqueous solutions. It is obvious from the equation LOD = 3δ/S that the limit of detection (LOD) of FSTB for CN− is significantly lower than the permissible level of CN− in drinkable water recommended by the World Health Organization. Therefore, the magnetic sensor FSTB has a wide range of applications for detecting and removing harmful CN−. [ABSTRACT FROM AUTHOR]

Among various kinds of photothermal conversion materials, polypyrrole (PPy) has attracted ever‐increasing attention because of its good biocompatibility and excellent near‐infrared light response property. In this research, the core‐shell nanoparticles with magnetic Fe3O4 as the core and mesoporous silica (MSN) as the shell were prepared, the resulted Fe3O4@MSN nanoparticles were then surface coated with a layer of PPy and further modified with polyvinylpyrrolidone (PVP) to gain colloidal stability. The Fe2+ in Fe3O4 can catalyze the decomposition of H2O2 in tumor cells to produce cytotoxic hydroxyl radicals, thus realizing the tumor chemodynamic therapy. Meanwhile, the MSN layer gives the nanoparticles a higher drug loading capacity of chemotherapeutics (doxorubicin, DOX). Therefore, the prepared Fe3O4@MSN@PPy‐PVP nanoparticles not only have good biocompatibility, magnetism and colloidal stability but also can realize the combined tumor photothermal, chemo, and chemodynamic therapy. This study demonstrates the rational design of multifunctional nanoplatforms for biomedical applications. [ABSTRACT FROM AUTHOR]

The hierarchically structured core‐shell magnetic mesoporous silica nanospheres (Mag‐MSNs) have attracted extensive attention, particularly in studies involving reliable preparations and diverse applications of the multifunctional nanomaterials in multi‐disciplinary fields. Intriguingly, Mag‐MSNs have been prepared with well‐designed synthesis strategies and used as adsorbent materials, biomedicines, and in proteomics and catalysis due to their excellent magnetic responsiveness, enormous specific surface area and readiness for surface modifications. Through a carefully designed surface modification of Mag‐MSNs, the performance and application prospects of the material are greatly improved. Typically, the introduction of various molecular matrices into the shell of Mag‐MSNs facilitates the combination of surface modifications and magnetic separation technology. So far, as sustainable chemistry is concerned, it is important to recover the functionalized core‐shell Mag‐MSNs after the reaction and reuse them without losing activity. In this review, the design conceptions and the construction of core‐shell Mag‐MSNs are discussed. Furthermore, various surface modification approaches of core‐shell Mag‐MSNs are summarized, and recent applications of these functionalized nanomaterials in the fields of biomedicine, catalysis, proteomics and wastewater treatment are exemplified. [ABSTRACT FROM AUTHOR]

Abstract The clinical translation potential of mesenchymal stem cells (MSCs) in regenerative medicine has been greatly exploited. With the merits of high surface area to volume ratio, facile control of components, well retained topography, and the capacity to mimic the native extracellular matrix (ECM), nanofibers have received a great deal of attention as bone tissue engineering scaffolds. Electrospinning has been considered as an efficient approach for scale-up fabrication of nanofibrous materials. Electrospun nanofibers are capable of stimulating cell–matrix interaction to form a cell niche, directing cellular behavior, and promoting the MSCs adhesion and proliferation. In this review, we give a comprehensive literature survey on the mechanisms of electrospun nanofibers in supporting the MSCs differentiation. Specifically, the influences of biological and physical osteogenic inductive cues on the MSCs osteogenic differentiation are reviewed. Along with the significant advances in the field, current research challenges and future perspectives are also discussed. Graphical Abstract This review gives a comprehensive literature survey on the mechanisms of electrospun nanofibers in supporting the MSCs differentiation. The influences of chemical or physical osteogenic inductive cues on the MSCs osteogenic differentiation are reviewed. Along with the significant advances in the field, current research challenges and future perspectives are also discussed. Image 1 Highlights • The application potentials of various kinds of electrospun nanofibers used for MSCs-based bone tissue engineering were summarized. • Inorganic inductive materials with osteoinductive and osteoconductive properties could alter the mechanical property of electrospun nanofibers, which could be then converted to biochemical signals that are able to active the osteogenic differentiation. • Organic cues could be encapsulated by electrospun nanofibers and their release from the nanofiber matrix could be controlled to a sustained release manner so as to realize a better osteogenic differentiation outcome. • Topological cues included fiber diameter, pores, orientation, patterns and other stimuli such as the mechanical property and surface conductivity could direct the cell growth along the aligned nanofiber orientation or micropattern direction to present different cell shapes, which were conductive for specific differentiation of MSCs. [ABSTRACT FROM AUTHOR]