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There is a win-win relationship of synergism and benign interaction between university journals and discipline construction, which plays an important role in showcasing innovative achievements, promoting talent training and leading discipline development. It is necessary to actively enhance the participation of journals in discipline construction, explore ways to focus on the development direction of key disciplines, give full play to the academic orientation of editorial board, and gather discipline achievements and talents to help discipline construction and development.

Human immunodeficiency virus (HIV) infection is still a global public health issue, and the development of an effective prophylactic vaccine inducing potent neutralizing antibodies remains a significant challenge. This study aims to explore the inflammation‐related proteins associated with the neutralizing antibodies induced by the DNA/rTV vaccine. In this study, we employed the Olink chip to analyze the inflammation‐related proteins in plasma in healthy individuals receiving HIV candidate vaccine (DNA priming and recombinant vaccinia virus rTV boosting) and compared the differences between neutralizing antibody‐positive (nab +) and –negative(nab‐) groups. We identified 25 differentially expressed factors and conducted enrichment and correlation analysis on them. Our results revealed that significant expression differences in artemin (ARTN) and C‐C motif chemokine ligand 23 (CCL23) between nab+ and –nab‐ groups. Notably, the expression of CCL23 was negatively corelated to the ID50 of neutralizing antibodies and the intensity of the CD4+ T cell responses. This study enriches our understanding of the immune picture induced by the DNA/rTV vaccine, and provides insights for future HIV vaccine development. [ABSTRACT FROM AUTHOR]

To reduce energy consumption and save economic costs, waste-derived secondary resources can be considered as cement substitutes for emulsified asphalt. Considering emulsion type and red mud–based alkali-activated materials dosage and curing time, this study determined the feasibility of using red mud–based geopolymer to replace the commonly used cement in emulsified asphalt. Experimental tests, including pH tests, optical microscopy tests, dynamic shear rheological (DSR) tests, and Fourier-transform infrared (FTIR) spectroscopy tests were performed to characterize the rheological properties, interaction, and microstructure characteristic of red mud–based geopolymer emulsified asphalt composite binder (REACB). Cement emulsified asphalt composite binder (CEACB) was selected for comparison. The pH test and optical microscope tests demonstrated that the influence of red mud–based geopolymer on demulsification speed of stearyl trimethyl ammonium chloride (STAC) emulsion was greater than that of sodium dodecylbenzene sulfonate (SDBS) emulsion. The dynamic shear rheological test results showed that with the increase of curing time and red mud–based alkali-activated materials dosage, both the deformation resistance and the elastic recovery ability of REACB were improved, and the interaction ability between red mud–based geopolymer and SDBS emulsified asphalt gradually became stronger than that of STAC emulsified asphalt. Moreover, geopolymerization reactions in two kinds of REACB were proved using stretching vibration peaks of the asymmetric functional group T-O-Si. This study will promote the utilization of red mud–based aluminosilicate waste in emulsified asphalt. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate the molecular mechanism by which the transcription factor ETS1 regulates N‐myc downstream regulatory gene 1 (NDRG1) to provide a new theoretical basis for the study of oral squamous cell carcinoma (OSCC). Methods: In this study, eight human OSCC and paraneoplastic samples were collected. The expressions of NDRG1, ETS1, and Ki67 were detected by immunohistochemistry; apoptosis was detected by tdt‐mediated dUTP notched end labeling; cell migration and invasion were detected by Transwell; quantitative real‐time PCR was performed to detect the expression of NDRG1; RNA‐binding protein immunoprecipitation (RIP) assays detected NDRG1 expression; immunofluorescence assays detected ETS1 expression. Results: NDRG1 and ETS1 expression was significantly upregulated in cancer tissues and CAL‐27 and SCC‐6 cells. Knockdown of NDRG1 and ETS1 inhibited cell proliferation, migration, invasion, cloning, and EMT while promoting apoptosis and inhibited tumor development; ETS1 positively regulated NDRG1 expression; Finally, overexpression of NDRG1 in vivo and in vitro reversed the effect of ETS1 knockdown on CAL‐27 and SCC‐6 cells. Conclusions: ETS1 positively regulates the expression of NDRG1 and promotes OSCC. Therefore, ETS1 may serve as a new target for the clinical diagnosis and treatment of OSCC. [ABSTRACT FROM AUTHOR]