Search

Your search keyword '"Wang Yuguang"' showing total 1,323 results
Start Over Author "Wang Yuguang"
1,323 results on '"Wang Yuguang"'

167. Oxygen‐Free Polycationic Photosensitizers for Treatment of Periodontal Inflammation.

Author

Qian, Yuping, Sun, Yujie, Zhang, Ludan, Zhu, Yiwen, Li, Ningyu, Dong, Fan, Xu, Chen, An, Na, Chen, Hu, Sun, Yuchun, Yu, Bingran, Wang, Yuguang, and Xu, Fu‐Jian

Subjects
REACTIVE oxygen species, BRANCHED polymers, CATIONIC polymers, BACTERIAL cell surfaces, DEXTRAN, PHOTODYNAMIC therapy, PATHOGENIC bacteria
Abstract

Periodontal tissue infection is a chronic destructive inflammatory disease caused by bacteria including anaerobes and facultative anaerobes. Traditional mechanical debridement and antibiotic treatments are not effective at removing biofilm from the root surface, resulting in recurrent disease. Antimicrobial photodynamic therapy (aPDT) is a promising bactericidal method, but it is limited by oxygen content. Here, an oxygen‐free cationic polymer (HQRB‐SS‐Dex) containing the photosensitizer rose bengal (RB) and dextran is proposed. It releases both 1O2 and HO•, and it exhibits strong antibacterial efficiency against periodontal pathogenic bacteria under irradiation. The positively charged quaternary ammonium polymer and dextran of HQRB‐SS‐Dex facilitate adherence to the bacterial surface and penetration of the bacterial biofilm to permit efficient use of reactive oxygen species. Disulfide bonds make the complex biodegradable, which improves biosafety. This work presents a unique branched cationic polymer for oxygen‐free aPDT, with potential application to the treatment of periodontal infection. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

168. Delayed Reaction of Radiation on the Central Nervous System and Bone System in C57BL/6J Mice.

Author

Ru, Yi, Zhang, Xianxie, Shen, Baoying, Yang, Chunqi, Yu, Huijing, Liu, Zuoxu, Wu, Xiangjun, Li, Fangyang, Cui, Jialu, Lai, Chengcai, Wang, Yuguang, and Gao, Yue

Subjects
LABORATORY mice, CENTRAL nervous system, TOTAL body irradiation, RADIATION injuries, IONIZING radiation, BONE density, DOSE-response relationship (Radiation), DNA damage
Abstract

The aim of this study was to provide a suitable mouse model of radiation-induced delayed reaction and identify potential targets for drug development related to the prevention and treatment of radiation injury. C57BL/6J mice were subjected to singular (109 cGy/min, 5 Gy*1) and fractional (109 cGy/min, 5 Gy*2) total body irradiation. The behavior and activity of mice were assessed 60 days after ionizing radiation (IR) exposure. After that, the pathological changes and mechanism of the mouse brain and femoral tissues were observed by HE, Nissl, Trap staining micro-CT scanning and RNA sequencing (RNA-Seq), and Western blot. The results show that singular or fractional IR exposure led to a decrease in spatial memory ability and activity in mice, and the cognitive and motor functions gradually recovered after singular 5 Gy IR in a time-dependent manner, while the fractional 10 Gy IR group could not recover. The decrease in bone density due to the increase in osteoclast number may be relative to the down-regulation of RUNX2, sclerostin, and beta-catenin. Meanwhile, the brain injury caused by IR exposure is mainly linked to the down-regulation of BNDF and Tau. IR exposure leads to memory impairment, reduced activity, and self-recovery, which are associated with time and dose. The mechanism of cognitive and activity damage was mainly related to oxidative stress and apoptosis induced by DNA damage. The damage caused by fractional 10 Gy TBI is relatively stable and can be used as a stable multi-organ injury model for radiation mechanism research and anti-radiation medicine screening. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

184. A 3D biomimetic optoelectronic scaffold repairs cranial defects

Author

Wang, Huachun, primary, Tian, Jingjing, additional, Jiang, Yuxi, additional, Liu, Shuang, additional, Zheng, Jingchuan, additional, Li, Ningyu, additional, Wang, Guiyan, additional, Dong, Fan, additional, Chen, Junyu, additional, Xie, Yang, additional, Huang, Yunxiang, additional, Cai, Xue, additional, Wang, Xiumei, additional, Xiong, Wei, additional, Qi, Hui, additional, Yin, Lan, additional, Wang, Yuguang, additional, and Sheng, Xing, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results