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592 results on '"Weiss, Roy"'

151. Adeno Associated Virus 9–Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice

Author

Iwayama, Hideyuki, Liao, Xiao-Hui, Braun, Lyndsey, Bárez-López, Soledad, Kaspar, Brian, Weiss, Roy E., Dumitrescu, Alexandra M., Guadaño-Ferraz, Ana, Refetoff, Samuel, Iwayama, Hideyuki, Liao, Xiao-Hui, Braun, Lyndsey, Bárez-López, Soledad, Kaspar, Brian, Weiss, Roy E., Dumitrescu, Alexandra M., Guadaño-Ferraz, Ana, and Refetoff, Samuel

Published
2016

152. Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor [Alpha]

Author

Macchia, Paolo E., Takeuchi, Yoko, Kawai, Tomoko, Cua, Kevin, Gauthier, Karine, Chassande, Olivier, Seo, Hisao, Hayashi, Yoshitaka, Samarut, Jacques, Murata, Yoshiharu, Weiss, Roy E., and Refetoff, Samuel

Subjects
Thyroid hormones -- Physiological aspects, Hormone receptors -- Physiological aspects, Mice, mutant strains -- Physiological aspects, Science and technology
Abstract

Only three of the four thyroid hormone receptor (TR) isoforms, [Alpha]1, [Beta]1, and [Beta]2, bind thyroid hormone (TH) and are considered to be true TRs. TR[Alpha]2 binds to TH response elements on DNA, but its role in vivo is still unknown. We produced mice completely deficient in TR[Alpha] (TR[[Alpha].sup.o/o]) that maintain normal serum thyroid-stimulating hormone (TSH) concentration despite low serum thyroxine ([T.sub.4]), suggesting increased sensitivity to TH. We therefore examined the effects of TH (L-3,3',5-triiodothyronine, L-[T.sub.3]) given to TH-deprived and to intact TR[[Alpha].sup.o/o] mice. Controls were wild-type (WT) mice of the same strain and mice resistant to TH due to deficiency in TR[Beta] (TR[[Beta].sup.-/-]). In liver, [T.sub.3] produced significantly greater responses in TR[[Alpha].sup.o/o] and smaller responses in TR[[Beta].sup.-/-] as compared with WT mice. In contrast, cardiac responses to L-[T.sub.3] were absent or reduced in TR[[Alpha].sup.o/o], whereas they were similar in WT and TR[Beta]-/- mice, supporting the notion that TR[Alpha]1 is the dominant TH-dependent TR isoform in heart. 5-Triiodothyronine (L-[T.sub.3]) given to intact mice produced a greater suppression of serum [T.sub.4] in TR[[Alpha].sup.o/o] than it did in WT mice and reduced by a greater amount the TSH response to TSH-releasing hormone. This is an in vivo demonstration that a TR deficiency can enhance sensitivity to TH. This effect is likely due to the abrogation of the constitutive 'silencing' effect of TR[Alpha]2 in tissues expressing the TR[Beta] isoforms.

Published
2001

153. American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

Author

Bianco, Antonio C., Anderson, Grant, Forrest, Douglas, Galton, Valerie Anne, Gereben, Balázs, Kim, Brian W., Kopp, Peter A., Liao, Xiao Hui, Obregon, Maria Jesus, Peeters, Robin P., Refetoff, Samuel, Sharlin, David S., Simonides, Warner S., Weiss, Roy E., Williams, Graham R., Internal Medicine, Physiology, and ICaR - Heartfailure and pulmonary arterial hypertension

Subjects
endocrine system, endocrine system diseases, SDG 3 - Good Health and Well-being
Abstract

Background: An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease. Summary: Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer are the result of laboratory discoveries made by scientists investigating the most basic aspects of thyroid structure and molecular biology. In this document, a panel of experts commissioned by the American Thyroid Association makes a series of recommendations related to the study of thyroid hormone economy and action. These recommendations are intended to promote standardization of study design, which should in turn increase the comparability and reproducibility of experimental findings. Conclusions: It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes.

Published
2014

154. Adeno Associated Virus 9–Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice

Author

Iwayama, Hideyuki, primary, Liao, Xiao-Hui, additional, Braun, Lyndsey, additional, Bárez-López, Soledad, additional, Kaspar, Brian, additional, Weiss, Roy E., additional, Dumitrescu, Alexandra M., additional, Guadaño-Ferraz, Ana, additional, and Refetoff, Samuel, additional

Published
2016
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158. Road network selection for small-scale maps using an improved centrality-based algorithm

Author

Weiss, Roy, Weibel, Robert, Weiss, Roy, and Weibel, Robert

Abstract

The road network is one of the key feature classes in topographic maps and databases. In the task of deriving road networks for products at smaller scales, road network selection forms a prerequisite for all other generalization operators, and is thus a fundamental operation in the overall process of topographic map and database production. The objective of this work was to develop an algorithm for automated road network selection from a large-scale (1:10,000) to a small-scale database (1:200,000). The project was pursued in collaboration with swisstopo, the national mapping agency of Switzerland, with generic mapping requirements in mind. Preliminary experiments suggested that a selection algorithm based on betweenness centrality performed best for this purpose, yet also exposed problems. The main contribution of this paper thus consists of four extensions that address deficiencies of the basic centrality-based algorithm and lead to a significant improvement of the results. The first two extensions improve the formation of strokes concatenating the road segments, which is crucial since strokes provide the foundation upon which the network centrality measure is computed. Thus, the first extension ensures that roundabouts are detected and collapsed, thus avoiding interruptions of strokes by roundabouts, while the second introduces additional semantics in the process of stroke formation, allowing longer and more plausible strokes to built. The third extension detects areas of high road density (i.e., urban areas) using density-based clustering and then locally increases the threshold of the centrality measure used to select road segments, such that more thinning takes place in those areas. Finally, since the basic algorithm tends to create dead-ends—which however are not tolerated in small-scale maps—the fourth extension reconnects these dead-ends to the main network, searching for the best path in the main heading of the dead-end.

Published
2014

165. Classification and Proposed Nomenclature for Inherited Defects of Thyroid Hormone Action, Cell Transport, and Metabolism

Author

Refetoff, Samuel, primary, Bassett, J.H. Duncan, additional, Beck-Peccoz, Paolo, additional, Bernal, Juan, additional, Brent, Gregory, additional, Chatterjee, Krishna, additional, De Groot, Leslie J., additional, Dumitrescu, Alexandra M., additional, Jameson, J. Larry, additional, Kopp, Peter A., additional, Murata, Yoshiharu, additional, Persani, Luca, additional, Samarut, Jacques, additional, Weiss, Roy E., additional, Williams, Graham R., additional, and Yen, Paul M., additional

Published
2014
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166. Impact of GH replacement therapy on sleep in adult patients with GH deficiency of pituitary origin.

Author

Morselli, Lisa L, Nedeltcheva, Arlet, Leproult, Rachel, Spiegel, Karine, Martino, Enio, Legros, Jean-Jacques, Weiss, Roy E., Mockel, Jean, Van Cauter, Eve, Copinschi, Georges, Morselli, Lisa L, Nedeltcheva, Arlet, Leproult, Rachel, Spiegel, Karine, Martino, Enio, Legros, Jean-Jacques, Weiss, Roy E., Mockel, Jean, Van Cauter, Eve, and Copinschi, Georges

Abstract

We previously reported that adult patients with GH deficiency (GHD) due to a confirmed or likely pituitary defect, compared with healthy controls individually matched for age, gender, and BMI, have more slow-wave sleep (SWS) and higher delta activity (a marker of SWS intensity). Here, we examined the impact of recombinant human GH (rhGH) therapy, compared with placebo, on objective sleep quality in a subset of patients from the same cohort., Journal Article, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2013

167. TSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasia.

Author

UCL - SSS/IREC/MORF - Pôle de Morphologie, Müller, Kathrin, Führer, Dagmar, Mittag, Jens, Klöting, Nora, Blüher, Matthias, Weiss, Roy E, Many, Marie-Christine, Kurt Werner, Schmid, Krohn, Knut, UCL - SSS/IREC/MORF - Pôle de Morphologie, Müller, Kathrin, Führer, Dagmar, Mittag, Jens, Klöting, Nora, Blüher, Matthias, Weiss, Roy E, Many, Marie-Christine, Kurt Werner, Schmid, and Krohn, Knut

Abstract

Although TSH stimulates all aspects of thyroid physiology IGF-I signaling through a tyrosine kinase-containing transmembrane receptor exhibits a permissive impact on TSH action. To better understand the importance of the IGF-I receptor in the thyroid in vivo, we inactivated the Igf1r with a Tg promoter-driven Cre-lox system in mice. We studied male and female mice with thyroidal wild-type, Igf1r(+/-), and Igf1r(-/-) genotypes. Targeted Igf1r inactivation did transiently reduce thyroid hormone levels and significantly increased TSH levels in both heterozygous and homozygous mice without affecting thyroid weight. Histological analysis of thyroid tissue with Igf1r inactivation revealed hyperplasia and heterogeneous follicle structure. From 4 months of age, we detected papillary thyroid architecture in heterozygous and homozygous mice. We also noted increased body weight of male mice with a homozygous thyroidal null mutation in the Igf1r locus, compared with wild-type mice, respectively. A decrease of mRNA and protein for thyroid peroxidase and increased mRNA and protein for IGF-II receptor but no significant mRNA changes for the insulin receptor, the TSH receptor, and the sodium-iodide-symporter in both Igf1r(+/-) and Igf1r(-/-) mice were detected. Our results suggest that the strong increase of TSH benefits papillary thyroid hyperplasia and completely compensates the loss of IGF-I receptor signaling at the level of thyroid hormones without significant increase in thyroid weight. This could indicate that the IGF-I receptor signaling is less essential for thyroid hormone synthesis but maintains homeostasis and normal thyroid morphogenesis.

Published
2011

168. Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes.

Author

Liao, Xiao Hui, Di Cosmo, Caterina, Dumitrescu, Alexandra Mihai, Hernandez, Arturo, Van Sande, Jacqueline, St Germain, Donald L, Weiss, Roy E., Galton, Valerie Anne, Refetoff, Samuel, Liao, Xiao Hui, Di Cosmo, Caterina, Dumitrescu, Alexandra Mihai, Hernandez, Arturo, Van Sande, Jacqueline, St Germain, Donald L, Weiss, Roy E., Galton, Valerie Anne, and Refetoff, Samuel

Abstract

Mice deficient in the thyroid hormone (TH) transporter Mct8 (Mct8KO) have increased 5'-deiodination and impaired TH secretion and excretion. These and other unknown mechanisms result in the low-serum T(4), high T(3), and low rT(3) levels characteristic of Mct8 defects. We investigated to what extent each of the 5'-deiodinases (D1, D2) contributes to the serum TH abnormalities of the Mct8KO by generating mice with all combinations of Mct8 and D1 and/or D2 deficiencies and comparing the resulting eight genotypes. Adding D1 deficiency to that of Mct8 corrected the serum TH abnormalities of Mct8KO mice, normalized brain T(3) content, and reduced the impaired expression of TH-responsive genes. In contrast, Mct8D2KO mice maintained the serum TH abnormalities of Mct8KO mice. However, the serum TSH level increased 27-fold, suggesting a severely impaired hypothalamo-pituitary-thyroid axis. The brain of Mct8D2KO manifested a pattern of more severe impairment of TH action than Mct8KO alone. In triple Mct8D1D2KO mice, the markedly increased serum TH levels produced milder brain defect than that of Mct8D2KO at the expense of more severe liver thyrotoxicosis. Additionally, we observed that mice deficient in D2 had an unexplained marked reduction in the thyroid growth response to TSH. Our studies on these eight genotypes provide a unique insight into the complex interplay of the deiodinases in the Mct8 defect and suggest that D1 contributes to the increased serum T(3) in Mct8 deficiency, whereas D2 mainly functions locally, converting T(4) to T(3) to compensate for distinct cellular TH depletion in Mct8KO mice., Journal Article, Research Support, N.I.H. Extramural, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2011

169. Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

Author

Vatner, Daniel F., primary, Weismann, Dirk, additional, Beddow, Sara A., additional, Kumashiro, Naoki, additional, Erion, Derek M., additional, Liao, Xiao-Hui, additional, Grover, Gary J., additional, Webb, Paul, additional, Phillips, Kevin J., additional, Weiss, Roy E., additional, Bogan, Jonathan S., additional, Baxter, John, additional, Shulman, Gerald I., additional, and Samuel, Varman T., additional

Published
2013
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172. Transsphenoidal Surgery for Cushing Disease

Author

Ciric, Ivan, primary, Zhao, Jin-Cheng, additional, Du, Hongyan, additional, Findling, James W., additional, Molitch, Mark E., additional, Weiss, Roy E., additional, Refetoff, Samuel, additional, Kerr, William D., additional, and Meyer, Joel, additional

Published
2012
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174. The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis

Author

Astapova, Inna, primary, Vella, Kristen R., additional, Ramadoss, Preeti, additional, Holtz, Kaila A., additional, Rodwin, Benjamin A., additional, Liao, Xiao-Hui, additional, Weiss, Roy E., additional, Rosenberg, Michael A., additional, Rosenzweig, Anthony, additional, and Hollenberg, Anthony N., additional

Published
2011
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187. Medical Mimics

Author

PEARL, PHILLIP L., primary, WEISS, ROY E., additional, and STEIN, MARK A., additional

Published
2006
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188. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism

Author

Dumitrescu, Alexandra M, primary, Liao, Xiao-Hui, additional, Abdullah, Mohamed S Y, additional, Lado-Abeal, Joaquin, additional, Majed, Fathia Abdul, additional, Moeller, Lars C, additional, Boran, Gerard, additional, Schomburg, Lutz, additional, Weiss, Roy E, additional, and Refetoff, Samuel, additional

Published
2005
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