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834 results on '"Wen, Ming-Shien"'

151. Promoting vascular healing using nanofibrous ticagrelor-eluting stents

Author

Lee,Cheng-Hung, Hsieh,Ming-Jer, Liu,Kuo-Sheng, Cheng,Che-Wei, Chang,Shang-Hung, Liu,Shih-Jung, Wang,Chao-Jan, Hsu,Ming-Yi, Hung,Kuo-Chun, Yeh,Yung-Hsin, Chen,Wei-Jan, Hsieh,I-Chang, Juang,Jyuhn-Huarng, Wen,Ming-Shien, Lee,Cheng-Hung, Hsieh,Ming-Jer, Liu,Kuo-Sheng, Cheng,Che-Wei, Chang,Shang-Hung, Liu,Shih-Jung, Wang,Chao-Jan, Hsu,Ming-Yi, Hung,Kuo-Chun, Yeh,Yung-Hsin, Chen,Wei-Jan, Hsieh,I-Chang, Juang,Jyuhn-Huarng, and Wen,Ming-Shien

Abstract

Cheng-Hung Lee,1 Ming-Jer Hsieh,1 Kuo-Sheng Liu,2,3 Che-Wei Cheng,3 Shang-Hung Chang,1 Shih-Jung Liu,3,4 Chao-Jan Wang,5 Ming-Yi Hsu,5 Kuo-Chun Hung,1 Yung-Hsin Yeh,1 Wei-Jan Chen,1 I-Chang Hsieh,1 Jyuhn-Huarng Juang,6 Ming-Shien Wen1 1Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Tao-Yuan, Taiwan; 2Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Linkou, Tao-Yuan, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan; 4Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; 5Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Tao-Yuan, Taiwan; 6Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung University and Chang Gung Memorial Hospital, Tao-Yuan, Taiwan Objective: The current treatment of atherosclerotic coronary heart disease with limus-eluting stents can lead to incomplete endothelialization and substantial impairment of arterial healing relative to treatment with bare-metal stents. The sustained and local delivery of ticagrelor, a reversibly binding P2Y12 receptor inhibitor, using hybrid biodegradable nanofibers/stents, was developed to reduce neointimal formation and endothelial dysfunction.Methods: In this investigation, a solution of ticagrelor, poly(D,L)-lactide-co-glycolide, and hexafluoro isopropanol was electrospun to fabricate ticagrelor-eluting nanofibrous drug-eluting stents. The in vitro and in vivo ticagrelor concentrations were measured using a high-performance liquid chromatography assay. The effectiveness of ticagrelor-eluting stents was examined relative to that of sirolimus-eluting stents. Results: Adequate ticagrelor levels were detected for four weeks in vitro. Less HES5-positive labeling was found near the ticagrelor-eluting stented vessels (0.33±0.12) than close to the sirolimus-eluting stented

Published
2018

153. Characteristics and radiofrequency ablation therapy of intermediate septal accessory pathway

Author

Yeh San-Jou, Wang Chun-Chieh, Wen Ming-Shien, Lin Fun-Chung, Koo Chee-Choong, Lo, Ying-Sui Archie, and Wu Delon

Subjects
Ventricular septal defects, Ablation (Surgery) -- Health aspects, Health
Abstract

Fourteen patients (5%) with an intermediate septal accessory pathway were identified among 283 consecutive patients with the Wolff-Parkinson-White syndrome who had electrophysiologic study and radiofrequency ablation therapy. Nine were women and 5 were men (mean age 33 [+ or -] 13 years). The resting electrocardiogram showed ventricular preexcitation in 8 patients and normal PR interval in 6. Anterograde and retrograde mapping studies revealed that the accessory pathway was para-Hisian in 11 patients and paranodal in 3. The accessory pathway was successfully ablated in 10 patients (9 para-Hisian and 1 paranodal) and damaged in 1 (para-Hisian). Treatment of 3 patients was complicated by transient atrioventricular (AV) block, of 1 by intermittent second-degree AV block, and of another by permanent complete AV block requiring implantation of a permanent pacemaker. Six patients underwent a follow-up electrophysiologic study 84 [+ or -] 55 days after ablation; none had induction of tachycardia even after isoproterenol infusion. It is concluded that radiofrequency ablation therapy for intermediate septal accessory pathway is feasible. However, the success rate is only modest (71%), whereas complications with heart block (36%) or complete right bundle branch block (29%) are high. Thus, the procedure should be reserved for patients with life-threatening or troublesome symptomatic tachyarrhythmias. (Am J Cardiol 1994;73:50-56)

Published
1994

154. Radiofrequency ablation in multiple accessory pathways and the physiologic implications

Author

Yeh San-Jou, Wang Chun-Chieh, Wen Ming-Shien, Lin Fun-Chung, and Wu Delon

Subjects
Wolff-Parkinson-White syndrome, Ablation (Surgery) -- Evaluation, Health
Abstract

The presence of multiple accessory pathways was noted in 24 of 210 consecutive patients (12 males and 12 females aged 15 to 77 years [mean [+ or -] SD 43 [+ or -] 16]) with the Wolff=Parkinson-White syndrome who underwent electrophysiologic study and rodiofrequency ablation. Six had 3 and 18 had 2 accessory pathways. There were 25 manifest and 29 concealed accessory pathways. The location of the accessory pathways was in the left free wall in 22, the right free wall in 17, the left posterior portion of the ventricular septum in 8, the right posterior portion of the ventricular septum in 6, and the midseptum in 1. The success rate of accessory pathway ablation and the fluoroscopic time in these 24 patients with miltiple accessory pathways were 89% and 78 [+ or -] 66 minutes, respectively, whereas they were 98% (p

Published
1993

155. Metformin is associated with fewer major adverse cardiac events among patients with a new diagnosis of type 2 diabetes mellitus

Author

Lee, Kuang-Tso, Yeh, Yung-Hsin, Chang, Shang-Hung, See, Lai-Chu, Lee, Cheng-Hung, Wu, Lung-Sheng, Liu, Jia-Rou, Kuo, Chi-Tai, and Wen, Ming-Shien

Subjects
Adult, Male, Adolescent, Databases, Factual, Heart Diseases, Incidence, Taiwan, Observational Study, Comorbidity, Middle Aged, Metformin, Young Adult, Diabetes Mellitus, Type 2, diabetes mellitus, Humans, Hypoglycemic Agents, Female, Longitudinal Studies, Propensity Score, major adverse cardiac events, Research Article, Follow-Up Studies, Aged, Proportional Hazards Models
Abstract

Early type 2 diabetes mellitus (DM) may only require lifestyle modifications for glycemic control without the need for oral hypoglycemic agents (OHAs). Metformin is believed to improve cardiovascular outcomes in patients with DM, and it is considered to be a first-line therapy. However, it is unclear whether metformin is beneficial for patients with a new diagnosis of DM compared to those who do not need OHAs for glycemic control. Data were obtained from a population-based health care database in Taiwan. Patients with a new diagnosis of DM were enrolled if they received metformin monotherapy only between 1999 and 2010. A 4:1 propensity score-matched cohort of patients with a new diagnosis of DM who did not take OHAs or insulin during follow-up was also enrolled. The primary study endpoint was the occurrence of major adverse cardiovascular events (MACEs). The time to the endpoints was compared between groups using Cox proportional hazards models. A total of 474,410 patients with DM were enrolled. During a mean 5.8 years of follow-up, the incidence of MACEs was 1.072% (1072 per 100,000 person-years) in the metformin monotherapy group versus 1.165% in the lifestyle modification group (those who did not take OHAs) (P

Published
2017

156. The Changing Landscape for Stroke Prevention in AF Findings From the GLORIA-AF Registry Phase 2

Author

Huisman, Menno V., Rothman, Kenneth J., Paquette, Miney, Teutsch, Christine, Diener, Hans-Christoph, Dubner, Sergio J., Halperin, Jonathan L., Chang Sheng, Ma, Zint, Kristina, Elsaesser, Amelie, Bartels, Dorothee B., Lip, Gregory Y. H., Abban, Dzifa, Abdul, Nasser, Abelson, Mark, Ackermann, Alan, Adams, Fran, Adams, Luthando, Adragão, Pedro, Ageno, Walter, Aggarwal, Rajesh, Agosti, Sergio, Marin, Javier Aguila, Aguilar, Francisco, Aguilar Linares, Julio Alberto, Aguinaga, Luis, Ahmad, Zia, Ainsworth, Paul, Al Ghalayini, Kamal, Al Ismail, Saad, Alasfar, Abdelfatah, Alawwa, Abdul, Al-Dallow, Raed, Alderson, Lisa, Alexopoulos, Dimitrios, Ali, Abdullah, Ali, Malik, Aliyar, Pareed, Al-Joundi, Tammam, Al Mahameed, Soufian, Almassi, Hossein, Almuti, Khalid, Al-Obaidi, Mohamed, Alshehri, Mohamed, Altmann, Ute, Alves, Alvaro Rabelo, Al-Zoebi, Ayham, Amara, Walid, Amelot, Mathieu, Amjadi, Nima, Ammirati, Fabrizio, Andrawis, Nabil, Angoulvant, Denis, Annoni, Giorgio, Ansalone, Gerardo, Antonescu, Sorin Alexandru, Ariani, Mehrdad, Arias, Juan Carlos, Armero, Sébastien, Arora, Rohit, Arora, Chander, Ashcraft, William, Aslam, M. Shakil, Astesiano, Alfredo, Audouin, Philippe, Augenbraun, Charles, Aydin, S., Azar, Rabih, Azim, Abul, Aziz, Shahid, Backes, Luciano Marcelo, Baig, Mirza, Bains, Suchdeep, Bakbak, Asaad, Baker, Seth, Bakhtiar, Karim, Bala, Richard, Banayan, Jonathan, Bandh, Stellan, Bando, Shigenobu, Banerjee, Subhash, Bank, Alan, Barbarash, Olga, Barón, Gonzalo, Barr, Craig, Barrera, Carlos, Barton, John, Kes, Vanja Basic, Baula, Giovanni, Bayeh, Hamid, Bazargani, Nooshin, Behrens, Steffen, Bell, Alan, Benezet-Mazuecos, Juan, Benhalima, Bouziane, Berdagué, Philippe, Berg van den, B. J., Bergen van, P. F. M. M., Berngard, Edvard, Bernstein, Richard, Berrospi, Percy, Berti, Sergio, Bertomeu, Vicente, Berz, Andrea, Bettencourt, Paulo, Betzu, Robert, Beyer-Westendorf, Jan, Bhagwat, Ravi, Black, Toby, Blanco Ibaceta, Jorge Hugo, Bloom, Stephen, Blumberg, Edwin, Mario, Bo, Bockisch, Valerie, Bøhmer, Ellen, Bongiorni, Maria Grazia, Boriani, Giuseppe, Bosch, Ralph, Boswijk, D. J., Bott, Jochen, Bottacchi, Edo, Kalan, Marica Bracic, Brandes, Axel, Bratland, Bjørn, Brautigam, Donald, Breton, Nicolas, Brouwers, P. J. A. M., Browne, Kevin, Bruguera, Jordi, Brunehaut, Myriam, Brunschwig, Claude, Buathier, Hervé, Buhl, Aurélie, Bullinga, John, Butcher, Kenneth, Cabrera Honorio, Jose Walter, Caccavo, Alberto, Cadinot, Didier, Cai, Shanglang, Calvi, Valeria, Camm, John, Candeias, Rui, Capo, James, Capucci, Alessandro, Cardoso, Juliano Novaes, Duarte Vera, Yan Carlos, Carlson, Brian, Carvalho, Paula, Cary, Susanna, Casanova, Rene, Casu, Gavino, Cattan, Simon, Cavallini, Claudio, Cayla, Guillaume, Cha, Tae Joon, Cha, Kwang Soo, Chaaban, Said, Chae, Jei Keon, Challappa, Krishnan, Chand, Sunil, Chandrashekar, Harinath, Chang, Mark, Charbel, Paul, Chartier, Ludovic, Chatterjee, Kausik, Cheema, Aamir, Chen, Shih-Ann, Chevallereau, Pierre, Chiang, Fu-Tien, Chiarella, Francesco, Chih-Chan, Lin, Cho, Yong Keun, Choi, Dong Ju, Chouinard, Guy, Danny, Null, Chow, Hoi Fan, Chrysos, Dimitrios, Chumakova, Galina, José Roberto Chuquiure Valenzuela, Eduardo Julián, Cieza-Lara, Tomas, Nica, Violeta Cindea, Ciobotaru, Vlad, Cislowski, David, Citerne, Olivier, Claus, Matthias, Clay, Anthony, Clifford, Piers, Cohen, Serge, Cohen, Andrew, Colivicchi, Furio, Collins, Rónán, Compton, Steve, Connors, Sean, Conti, Alberto, Buenostro, Gabriel Contreras, Coodley, Gregg, Cooper, Martin, Corbett, Lynn, Corey, Oran, Coronel, Julián, Corrigan, John, Cotrina Pereyra, Rosa Ysabel, Cottin, Yves, Coutu, Benoit, Cracan, Aurel, Crean, Peter, Crenshaw, James, Crijns, H. J. G. M., Crump, Charles, Cucher, Fred, Cudmore, David, Cui, Lianqun, Culp, John, Darius, Harald, Dary, Patrick, Dascotte, Olivier, Dauber, Ira, Davee, Thomas, Davies, Ruth, Davis, Gershan, Davy, Jean-Marc, Dayer, Mark, De La Briolle, Axel, de Mora, Manuel, De Teresa, Eduardo, De Wolf, Luc, Decoulx, Eric, Deepak, Sasalu, Defaye, Pascal, Del-Carpio Munoz, Freddy, Brkljacic, Diana Delic, Deluche, Laurent, Destrac, Sylvain, Deumite, N. Joseph, Di Legge, Silvia, Dibon, Olivier, Diemberger, Igor, Dillinger, Jean, Dionísio, Pedro, Naydenov, Stefan, Dotani, Imran, Dotcheva, Elena, D'Souza, Anthony, Dubrey, Simon, Ducrocq, Xavier, Dupljakov, Dmitry, Duthinh, Vuong, Dutra, Oscar Pereira, Dutta, Dipankar, Duvilla, Nathalie, Johnny, Dy, Dziewas, Rainer, Eaton, Charles, Eaves, William, Ebinger, Matthew, Eck van, J. W. M., Edwards, Tim, Egocheaga, Isabel, Ehrlich, Clifford, Eisenberg, Steven, El Hallak, Abdel, El Jabali, Adnan, El Mahmoud, Rami, El Shahawy, Mahfouz, Eldadah, Zayd, Elghelbazouri, Fouad, Elhag, Omar, El-Hamdani, Mehiar, Elias, Darlene, Ellery, Adam, El-Sayed, Hassan, Elvan, A., Erickson, Bernard, Espaliat, Eric, Essandoh, Louis, Everington, Tamara, Evonich, Rudolph, Ezhov, Andrey, Fácila, Lorenzo, Farsad, Ramin, Fayard, Maxime, Fedele, Francesco, Gomes Ferreira, Luis Gustavo, Ferreira, Daniel, Santos, José Ferreira, Ferrier, Anna, Finsen, Alexandra, First, Brian, Fisher, Raymond, Floyd, John, Folk, Thomas, Fonseca, Catarina, Fonseca, Luisa, Forman, Steven, Forsgren, Magnus, Foster, Malcolm, Foster, Nathan, Frais, Michael, Frandsen, Brad, Frappé, Thierry, Freixa, Ramon, French, William, Freydlin, Marina, Frickel, Siegfried, Fruntelata, Ana Gabriela, Fujii, Shigeru, Fujino, Yusuke, Fukunaga, Hiroshi, Furukawa, Yutaka, Gabelmann, Matthias, Gabris, Michael, Gadsbøll, Niels, Galin, Pavel, Galinier, Michel, Ganim, Ricky, Garcia, Ronnie, Quintana, Antonio Garcia, Gartenlaub, Olivier, Genz, Conrad, Georger, Frédéric, Georges, Jean-Louis, Georgeson, Steven, Ghanbasha, Ali, Giedrimas, Evaldas, Gierba, Mariusz, Gillespie, Eve, Giniger, Alberto, Gkotsis, Alexandros, Gmehling, Joachim, Gniot, Jacek, Goethals, Peter, Goldberg, Ronald, Goldmann, Britta, Goldscher, David, Golitsyn, Sergey, Gomez Lopez, Efrain Alonso, Gomez Mesa, Juan Esteban, Gonzalez, Efrain, Cocina, Emilio Gonzalez, Juanatey, Carlos Gonzalez, Gorbunov, Vladimir, Gordon, Brian, Gorka, Hervé, Gornick, Charles, Gorog, Diana, Goss, Franz, Götte, Andreas, Goube, Pascal, Goudevenos, Ioannis, Goulden, Dudley, Graham, Brett, Grande, Angel, Greco, Cesare, Green, Martin, Greer, Gerald, Gremmler, Uwe, Grena, Paul, Grinshstein, Yuriy, Grond, Martin, Gronda, Edoardo, Grondin, Francois, Grönefeld, Gerian, Groot de, J. R., Guardigli, Gabriele, Guarnieri, Thomas, Caiedo, Carolina Guevara, Guignier, Alexandre, Gulizia, Michele, Gumbley, Michael, Gupta, Dhiraj, Hack, Terrence, Haerer, Winfried, Hakas, Joseph, Hall, Christian, Hampsey, James, Hananis, Georgios, Hanbali, Basel, Handel, Franklin, Hargrove, Joe, Hargroves, David, Harris, Kenneth, Hartley, David, Haruna, Tetsuya, Hata, Yoshiki, Hayek, Emil, Healey, Jeff, Hearne, Steven, Heggelund, Geir, Hemels, M. E. W., Hemery, Yann, Henein, Sam, Henz, Benhur, Her, Sung-Ho, Hermany, Paul, Hernandes, Mauro Esteves, Higashino, Yorihiko, Hill, Michael, Hisadome, Tetsuo, Hishida, Eiji, Hitchcock, James, Hoffer, Etienne, Hoghton, Matthew, Holmes, Clare, Hong, Suk Keun, Houppe Nousse, Marie-Paule, Howard, Victor, Hsu, Li Fern, Huang, Chi-Hung, Huckins, David, Huehnergarth, Kier, Huizenga, A., Huntley, Richard, Hussein, Gamal, Hwang, Gyo-Seung, Igbokidi, Oyidie, Iglesias, Ignacio, Ikpoh, Margaret, Imberti, Davide, Ince, Hüseyin, Indolfi, Ciro, Ionova, Tatiana, John, Ip, Irles, Didier, Iseki, Harukazu, Ismail, Younus, Israel, Noah, Isserman, Steven, Iteld, Bruce, Ivanchura, Galina, Iyer, Ramakrishnan, Iyer, Venkat, Iza Villanueva, Ruben Omar, Jackson-Voyzey, Ewart, Jaffrani, Naseem, Jäger, Frank, Jain, Manish, James, Martin, Jamon, Yann, Jang, Sung Won, Pereira Jardim, Cesar Augusto, Jarmukli, Nabil, Jeanfreau, Robert, Jenkins, Ronald, Jiang, Xianyan, Jiang, Heng, Jiang, Tiemin, Jiang, Nan, Jimenez, Javier, Jobe, Robert, Joffe, Ian, Johansson, Bengt, Jones, Nick, Moura Jorge, Jose Carlos, Jouve, Bernard, Jundi, Mayar, Jung, Werner, Jung, Byung Chun, Jung, Kyung Tae, Kabbani, Samer, Kabour, Ameer, Kafkala, Chrystalenia, Kajiwara, Koji, Kalinina, Larisa, Kampus, Priit, Kanda, Junji, Kapadia, Shaival, Karim, Amin, Karolyi, Laszlo, Kashou, Hisham, Kastrup, Andreas, Katsivas, Apostolos, Kaufman, Elizabeth, Kawai, Kazuya, Kawajiri, Kenji, Kazmierski, John, Keeling, Phil, Kerfes, Galal Ali, Kerr Saraiva, José Francisco, Ketova, Galina, Khaira, Ajit, Khalid, Muhammad, Khludeeva, Elena, Khripun, Aleksey, Kim, Doo Il, Kim, Dae Kyeong, Kim, Nam Ho, Kim, Ki Seok, Kim, Young-Hoon, Kim, Jin bae, Kim, June Soo, Kim, Jeong Su, Kinova, Elena, Klein, Alexander, Kleinschnitz, Christoph, Kmetzo, James, Kneller, G. Larsen, Knezevic, Aleksandar, Koch, Stanley, Koenig, Kai, Angela Koh, Su Mei, Köhrmann, Martin, Koons, Jay, Korabathina, Ravikiran, Korennova, Olga, Koschutnik, Martin, Kosinski, Edward, Kovacic, Dragan, Kowalczyk, Jacek, Koziolova, Natalya, Kragten, J. A., Krause, Lars Udo, Kreidieh, Imad, Krenning, B. J., Krishnaswamy, Kannappan, Krysiak, Waldemar, Kuck, Karl-Heinz, Kumar, Somnath, Kümler, Thomas, Kuniss, Malte, Kuo, Jen-Yuan, Küppers, Achim, Kurrelmeyer, Karla, Kwan, Tak, Kyo, Eisho, Labovitz, Arthur, Lacroix, Alain, Lam, Andy, Lanas Zanetti, Fernando Tomas, Landau, Charles, Landini, Giancarlo, Lang, Wilfried, Larsen, Torben Bjerregaard, Laske, Volker, Lavandier, Karine, Law, Nicki, Lee, Moon Hyoung, Lee, Daniel, Leitão, Ana, Lejay, Dominique, Lelonek, Malgorzata, Lenarczyk, Radoslaw, Leprince, Patrick, Lequeux, Benoit, Leschke, Matthias, Ley, Nicolas, Zicheng, Li, Yansheng, Li, Xiaodong, Li, Zhanquan, Li, Weihua, Li, Liang, Jianqiu, Lieber, Ira, Lillestol, Michael, Limon Rodriguez, Ramon Horacio, Lin, Hailong, Lip, Gregory, Litchfield, Jennifer, Liu, Zhitao, Liu, Xuebo, Liu, Yalin, Liu, Feng, Liu, Wenhui, Llamas Esperon, Guillermo Antonio, Llisterri, Jose Luis, Ted, Lo, Eric, Lo, Lobos, Jose Maria, Lodde, Bernhard-Paul, Loiselet, Philippe, López-Sendón, José, Lorga Filho, Adalberto Menezes, Lori, Ido, Luo, Ming, Lupovitch, Steven, Lyrer, Philippe, Zuhairy, Hamed M., Changsheng, Ma, Genshan, Ma, Hong, Ma, Madariaga, Irene, Maeno, Koji, Magnin, Dominique, Mahmood, Shahid, Mahood, Karen, Maid, Gustavo, Mainigi, Sumeet, Makaritsis, Konstantinos, Maldonado Villalon, José Arturo, Malhotra, Rohit, Malik, Amir, Mallecourt, Catherine, Mallik, Rajiv, Manning, Rickey, Manolis, Athanasios, Mantas, Ioannis, Manzur Jattin, Fernando Gabriel, Marcionni, Niccolo', Marín, Francisco, Santana, Antonio Martín, Martinez, Jorge, Martinez, Luis, Maskova, Petra, Hernández, Norberto Matadamas, Matskeplishvili, Simon, Matsuda, Katsuhiro, Mavri, Alenka, May, Erik, Mayer, Nolan, Mazon, Pilar, Mcclure, John, Mccormack, Terry, Mcgarity, William, Mcguire, Michael, Mcintyre, Hugh, Mclaughlin, Paul, Mclaurin, Brent, Medina Palomino, Feliz Alvaro, Mehta, Paresh, Mehzad, Reza, Meinel, Andreas, Melandri, Francesco, Mena, Amparo, Meno, Hirosi, Menzies, Dhananjai, Metcalf, Kneale, Meyer, Beat, Miarka, Jacek, Mibach, Frank, Michalski, Dominik, Michel, Patrik, Chreih, Rami Mihail, Mikdadi, Ghiath, Mikhail, Magdy, Mikus, Milan, Milicic, Davor, Militaru, Constantin, Miller, Gary, Milonas, Christos, Minescu, Bogdan, Mintale, Iveta, Miralles, Aurélien, Mirault, Tristan, Mistry, Dinesh, Mitchell, George, Miu, Nicoleta Violeta, Miyamoto, Naomasa, Moccetti, Tiziano, Mohammed, Akber, Nor, Azlisham Mohd, Molina de Salazar, Dora Ines, Molon, Giulio, Molony, David, Mondillo, Sergio, Mont, Lluis, Moodley, Rajendra, Moore, Roger, Ribeiro Moreira, Dalmo Antonio, Mori, Kiyoo, Moriarty, Andrew, Morka, Jacek, Moschos, Nikitas, Mota Gomes, Marco Antônio, Mousallem, Nicolas, Moya, Angel, Mügge, Andreas, Mulhearn, Thomas, Muller, Jean-Joseph, Muresan, Carmen Manuela, Muse, Derek, Musial, Wlodzimierz, Musumeci, Francesco, Nadar, Venkatesh, Nageh, Thuraia, Nair, Priya, Nakagawa, Hidemitsu, Nakamura, Yuichiro, Nakayama, Toru, Nam, Ki-Byeong, Napalkov, Dmitry, Natarajan, Indira, Nayak, Hemal, Nechvatal, Libor, Neiman, James, Nerheim, Pamela, Neuenschwander, Fernando Carvalho, Nishida, Kunihiro, Nizov, Alexey, Novikova, Tatiana, Novo, Salvatore, Nowalany-Kozielska, Ewa, Nsah, Emmanuel, Nunez Fragoso, Juan Carlos, Nyvad, Ole, de Los Rios Ibarra, Manuel Odin, O'Donnell, Martin, O'Donnell, Philip, Dong Jin, Oh, Yong Seog, Oh, Daniel Oh, Chia Theng, O'Hara, Gilles, Oikonomou, Kostas, Olalla, Juan Jose, Olivari, Zoran, Oliver, Richard, Olympios, Christoforos, Osborne, John, Osca, Joaquin, Osman, Raed, Osunkoya, Abayomi, Padanilam, Benzy, Panchenko, Elizaveta, Pandey, A. Shekhar, Vicenzo de Paola, Angelo Amato, Paraschos, Alexander, Pardell, Herbert, Park, Hyung Wook, Park, Jong Sung, Parkash, Ratika, Parker, Ian, Parrens, Eric, Parris, Robert, Passamonti, Enrico, Patel, Jaydutt, Patel, Rajesh, Pentz, William H., Persic, Viktor, Perticone, Francesco, Peters, Patrick, Petkar, Sanjiv, Pezo, Luis Felipe, Pham, David, Cao Phai, Gérald Phan, Phlaum, Stephen, Pineau, Julien, Pineda-Velez, Armando, Pini, Riccardo, Pinter, Arnold, Pinto, Fausto, Pirelli, Salvatore, Pivac, Nediljko, Pizzini, Attilia Maria, Pocanic, Darko, Calin Podoleanu, Cristian Gheorghe, Polanczyk, Carisi Anne, Polasek, Petr, Poljakovic, Zdravka, Pollock, Stewart, Polo, Jose, Poock, James, Poppert, Holger, Porro, Yamile, Pose, Antonio, Poulain, François, Poulard, Jean-Ernst, Pouzar, Joe, Povolny, Petr, Pozzer, Domingo, Pras, Athanasios, Prasad, Neeraj, Prevot, Sébastien, Protasov, Konstantin, Prunier, Laurent, Puleo, John, Pye, Maurice, Qaddoura, Fatma, Quedillac, Jean-Michel, Raev, Dimitar, Rahimi, Sidiqullah, Raisaro, Arturo, Rama, Bhola, Ranadive, Nandkishore, Randall, Katie, Ranjith, Naresh, Raposo, Nuno, Rashid, Haroon, Raters, Christa, Rauch-Kroehnert, Ursula, Rebane, Thomas, Regner, Stefan, Renzi, Michael, Reyes Rocha, Miguel Agustin, Reza, Shabbir, Ria, Luigi, Richter, Dimitrios, Rickli, Hans, Rickner, Kyle, Rieker, Werner, Rigo, Fausto, Ripoll, Tomas, Fonteles Ritt, Luiz Eduardo, Roberts, Douglas, Pascual, Carlos Rodríguez, Briones, Ignacio Rodriguez, Reyes, Humberto Rodriguez, Roelke, Marc, Roman, Mark, Romeo, Francesco, Ronner, E., Ronziere, Thomas, Rooyer, F. A., Rosenbaum, David, Roth, Sherryn, Rozkova, Nadezda, Rubacek, Miroslav, Rubalcava, Frank, Rubanenko, Olesya, Rubin, Andrew, Borret, Mariano Ruiz, Rybak, Karin, Sabbour, Hani, Morales, Oscar Saenz, Sakai, Tetsuo, Salacata, Abraham, Salecker, Ilsbe, Salem, Adrien, Salfity, Marwan, Salguero, Rafael, Salvioni, Alessandro, Samson, Mercedes, Sanchez, Gregorio, Sandesara, Chirag, Saporito, Wladmir Faustino, Sasaoka, Taishi, Sattar, Payman, Savard, Daniel, Scala, Pierre-Jean, Scemama, Jacques, Schaupp, Thierry, Schellinger, Peter, Scherr, Carlos, Schmitz, Karl-Heinz, Schmitz, Bettina, Schmitz, Lisa, Schnitzler, Robert, Schnupp, Steffen, Schoeniger, Peter, Schön, Norbert, Schuster, Stefan, Schwimmbeck, Peter, Seamark, Clare, Seebass, Ruediger, Seidl, Karl-Heinz, Seidman, Barry, Sek, Jaroslaw, Sekaran, Lakshmanan, Seko, Yoshinori, Sepulveda Varela, Pablo Andres, Sevilla, Begoña, Shah, Vinay, Shah, Anil, Shah, Neerav, Shah, Aman, Shanes, Jeffrey, Sharareh, Ali, Sharma, Vijay Kumar, Shaw, Louise, Shimizu, Yutaka, Shimomura, Hideki, Shin, Dong Gu, Shin, Eun-Seok, Shite, Junya, Shoukfeh, Mohammad, Shoultz, Charles, Silver, Frank, Sime, Iveta, Simmers, T. A., Singal, Dinesh, Singh, Narendra, Siostrzonek, Peter, Sirajuddin, Mohiburrahman, Skeppholm, Mika, Smadja, Didier, Smith, Richard, Smith, David, Soda, Hassan, Sofley, C. Wilson, Sokal, Adam, Sotolongo, Rodolfo, de Souza, Olga Ferreira, Sparby, Jon Arne, Spinar, Jindrich, Sprigings, David, Spyropoulos, Alex, Stakos, Dimitrios, Steinberg, Alon, Steinwender, Clemens, Stergiou, Georgios, Stites, H. William, Stoikov, Anastas, Strasser, Ruth, Streb, Witold, Styliadis, Ioannis, Guohai, Su, Xi, Su, Suarez, Rafael Martin, Sudnik, Wanda, Sueyoshi, Atsushi, Sukles, Kai, Sun, Li, Suneja, Randeep, Svensson, Peter, Ziekenhuis, Antonius, Szavits-Nossan, Janko, Taggeselle, Jens, Takagi, Yuichiro, Takhar, Amrit, Tallet, Julio, Tamm, Angelika, Tanaka, Shozo, Tanaka, Katsumi, Tang, Aylmer, Tang, Sherman, Tassinari, Tiziana, Tayama, Shinji, Tayebjee, Muzahir, Tebbe, Ulrich, Teixeira, Jose, Tesloianu, Dan Nicolae, Tessier, Pascal, The, S. H. K., Thevenin, Jérome, Thomas, Harold, Timsit, Serge, Topkis, Robert, Torosoff, Mikhail, Touze, Emmanuel, Traissac, Thalie, Trendafilova, Elina, Troyan, Barry, Tsai, Wenchi Kevin, Tse, Hung Fat, Tsutsui, Hiroshi, Tsutsui, Takashi, Tuininga, Y. S., Turakhia, Minang, Turk, Samir, Turner, Wayne, Tveit, Arnljot, Twiddy, Shannon, Tytus, Richard, Ukrainski, Gerald, Valdovinos Chavez, Salvador Bruno, Van De Graaff, Eric, Vanacker, Peter, Vardas, Panagiotis, Vargas, Michael, Vassilikos, Vassilios, Vazquez, Juan, Venkataraman, Asok, Verdecchia, Paolo, Vester, Ernst Günter, Vial, Hubert, Vinereanu, Dragos, Vlastaris, Anthony, Vogel, Craig, vom Dahl, Jürgen, von Mering, Matthias, Vora, Kishor, Wakefield, Paul, Walia, Jasjit, Walter, Thomas, Wang, Mingsheng, Wang, Ningfu, Wang, Feng, Wang, Xinhua, Wang, Zulu, Wang, Kuo-Yang, Watanabe, Kouki, Wei, Jeanne, Weimar, Christian, Weinrich, Renate, Wen, Ming-Shien, Wheelan, Kevin, Wicke, Jens, Wiemer, Marcus, Wild, Beate, Wilke, Andreas, Willems, Stephan, Williams, Marcus, Williams, David, Winkler, Andreas, Wirtz, Jost Henner, Witzenbichler, Bernhard, Wong, Danny H. K., Lawrence Wong, Ka Sing, Wong, Brian, Wozakowska-Kaplon, Beata, Zhaohui, Wu, Shulin, Wu, Wyatt, Nell, Yong, Xu, Xiangdong, Xu, Yamada, Akira, Yamamoto, Kazuya, Yamanoue, Hiroki, Yamashita, Takeshi, Bryan Yan, Ping Yen, Yang, Yanmin, Yang, Tianlun, Yao, Jing, Yarlagadda, Chakri, Yeh, Kuo-Ho, Yotov, Yoto, Yvorra, Serge, Zahn, Ralf, Zamorano, José, Zanini, Roberto, Zarich, Stuart, Zebrack, James, Zenin, Sergei, Zeuthen, Elisabeth Louise, Zhang, Xingwei, Zhang, Quansan, Zhang, Dadong, Zhang, Donghui, Zhang, Huanyi, Zhao, Shuiping, Zhao, Xinwen, Zheng, Yang, Zheng, Qiangsun, Zhou, Jing, Zhou, Jian, Zimmermann, Sergio Luiz, Zimmermann, Rainer, Zukerman, L. Steven, and Zwaan van der, C.

Subjects
oral anticoagulation, cross-sectional studies, registries, antithrombins, registry, stroke, internationality, prospective studies, aged, cardiology and cardiovascular medicine, female, male, fibrinolytic agents, middle aged, dabigatran, atrial fibrillation, humans
Published
2017

158. Cardiovascular outcomes of vildagliptin in patients with type 2 diabetes mellitus after acute coronary syndrome or acute ischemic stroke.

Author

Chen, Dong‐Yi, Li, Yan‐Rong, Mao, Chun‐Tai, Tseng, Chi‐Nan, Hsieh, I‐Chang, Hung, Ming‐Jui, Chu, Pao‐Hsien, Wang, Chao‐Hung, Wen, Ming‐Shien, Cherng, Wen‐Jin, and Chen, Tien‐Hsing

Subjects
TYPE 2 diabetes, ACUTE coronary syndrome, NATIONAL health insurance, MYOCARDIAL infarction, STROKE
Abstract

Aims/Introduction: The cardiovascular (CV) outcomes of vildagliptin – a dipeptidyl peptidase‐4 inhibitor – in patients with type 2 diabetes mellitus after acute coronary syndrome or acute ischemic stroke are unclear. Materials and Methods: We analyzed data from the Taiwan National Health Insurance Research Database on 3,750 type 2 diabetes mellitus patients with acute coronary syndrome or acute ischemic stroke within 3 months between 1 August 2011 and 31 December 2013. Clinical outcomes were evaluated by comparing 1,250 participants receiving vildagliptin with 2,500 propensity score‐matched participants. The primary composite outcome included CV death, non‐fatal myocardial infarction and non‐fatal stroke. Results: The primary composite outcome occurred in 122 patients (9.8%) in the vildagliptin group and 263 patients (10.5%) in the control group (hazard ratio [HR] 0.90, 95% confidence interval [CI] 0.72–1.11) with a mean follow‐up period of 9.9 months. No significant between‐group differences were observed for CV death (HR 0.93, 95% CI 0.56–1.52), non‐fatal myocardial infarction (HR 0.79, 95% CI 0.46–1.36) and non‐fatal stroke (HR 0.96, 95% CI 0.74–1.24). The vildagliptin group was at similar risks of hospitalization for heart failure (HF) or coronary intervention to the control group (P = 0.312 and 0.430, respectively). For patients with HF at baseline, the risk of hospitalization for HF was similar between the vildagliptin and control groups (HR 1.04, 95% CI 0.57–1.88). Conclusions: Among patients with type 2 diabetes mellitus after a recent acute coronary syndrome or acute ischemic stroke, treatment with vildagliptin was not associated with increased risks of CV death, non‐fatal myocardial infarction, non‐fatal stroke and hospitalization for HF. [ABSTRACT FROM AUTHOR]

Published
2020
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162. Promoting vascular healing using nanofibrous ticagrelor-eluting stents

Author

Lee, Cheng-Hung, primary, Hsieh, Ming-Jer, additional, Liu, Kuo-Sheng, additional, Cheng, Che-Wei, additional, Chang, Shang-Hung, additional, Liu, Shih-Jung, additional, Wang, Chao-Jan, additional, Hsu, Ming-Yi, additional, Hung, Kuo-Chun, additional, Yeh, Yung-Hsin, additional, Chen, Wei-Jan, additional, Hsieh, I-Chang, additional, Juang, Jyuhn-Huarng, additional, and Wen, Ming-Shien, additional

Published
2018
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164. Outcomes of patients with hypertrophic cardiomyopathy and acute myocardial infarction: a propensity score-matched, 15-year nationwide population-based study in Asia

Author

Wu, Victor Chien-Chia, primary, Chen, Tien-Hsing, additional, Wu, Michael, additional, Chen, Shao-Wei, additional, Chang, Chih-Hsiang, additional, Chang, Chun-Wei, additional, Chen, Ching-Chang, additional, Wu, Katie Pei-Hsuan, additional, Hsieh, Ming-Jer, additional, Wang, Chao-Yung, additional, Chang, Shang-Hung, additional, Lin, Fen-Chiung, additional, Hsieh, I-Chang, additional, Chu, Pao-Hsien, additional, and Wen, Ming-Shien, additional

Published
2018
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169. TSOC-HFrEF Registry: A Registry of Hospitalized Patients with Decompensated Systolic Heart Failure: Description of Population and Management

Author

Wang, Chun-Chieh, Chang, Hung-Yu, Yin, Wei-Hsian, Wu, Yen-Wen, Chu, Pao-Hsien, Wu, Chih-Cheng, Hsu, Chih-Hsin, Wen, Ming-Shien, Voon, Wen-Chol, Lin, Wei-Shiang, Huang, Jin-Long, Chen, Shyh-Ming, Yang, Ning-I, Chang, Heng-Chia, Chang, Kuan-Cheng, Sung, Shih-Hsien, Shyu, Kou-Gi, Lin, Jiunn-Lee, Mar, Guang-Yuan, Chan, Kuei-Chuan, Kuo, Jen-Yuan, Wang, Ji-Hung, Chen, Zhih-Cherng, Tseng, Wei-Kung, and Cherng, Wen-Jin

Subjects
Original Article
Abstract

Heart failure (HF) is a medical condition with a rapidly increasing incidence both in Taiwan and worldwide. The objective of the TSOC-HFrEF registry was to assess epidemiology, etiology, clinical management, and outcomes in a large sample of hospitalized patients presenting with acute decompensated systolic HF.The TSOC-HFrEF registry was a prospective, multicenter, observational survey of patients presenting to 21 medical centers or teaching hospitals in Taiwan. Hospitalized patients with either acute new-onset HF or acute decompensation of chronic HFrEF were enrolled. Data including demographic characteristics, medical history, primary etiology of HF, precipitating factors for HF hospitalization, presenting symptoms and signs, diagnostic and treatment procedures, in-hospital mortality, length of stay, and discharge medications, were collected and analyzed.A total of 1509 patients were enrolled into the registry by the end of October 2014, with a mean age of 64 years (72% were male). Ischemic cardiomyopathy and dilated cardiomyopathy were diagnosed in 44% and 33% of patients, respectively. Coronary artery disease, hypertension, diabetes, and chronic renal insufficiency were the common comorbid conditions. Acute coronary syndrome, non-compliant to treatment, and concurrent infection were the major precipitating factors for acute decompensation. The median length of hospital stay was 8 days, and the in-hospital mortality rate was 2.4%. At discharge, 62% of patients were prescribed either angiotensin-converting enzyme-inhibitors or angiotensin receptor blockers, 60% were prescribed beta-blockers, and 49% were prescribed mineralocorticoid receptor antagonists.The TSOC-HFrEF registry provided important insights into the current clinical characteristics and management of hospitalized decompensated systolic HF patients in Taiwan. One important observation was that adherence to guideline-directed medical therapy was suboptimal.

Published
2016

170. Conjunction of Endocardial and Coronary Venous System Mapping to Ablate Ventricular Arrhythmias

Author

Wo, Hung-Ta, Yeh, Jih-Kai, Chang, Po-Cheng, Wen, Ming-Shien, Wang, Chun-Chieh, Chou, Chung-Chuan, and Yeh, San-Jou

Subjects
Brief Report
Abstract

Ablation of idiopathic ventricular arrhythmias (VAs) with epicardial or intramural origins is technically challenging. Herein, we have described the successful ablation of left VAs via the coronary venous system (CVS) in conjunction with endocardial map guided by three-dimensional electroanatomical map in six patients.Out of a total consecutive 84 patients with symptomatic idiopathic VAs, radiofrequency ablation via the CVS was performed on six patients (7%). Furthermore, we reviewed patient records and electrophysiologic studies with respect to clinical characteristics.Activation map was conducted in 5 patients, and the earliest activation sites were identified within the CVS. The preceding times to the onset of QRS complex were longer than those at the earliest endocardial sites (36.2 ± 5.6 ms vs. 14.2 ± 6.4 ms, p = 0.02, n = 5). Spiky fractionated long-duration potentials were recorded at the successful ablation sites in all 5 patients. The other patient received pacemapping only because of few spontaneous VAs during the procedure, and the best pacemap spot was found within the CVS. Irrigated catheters were required in 4 out of 6 patients because VAs were temporarily suppressed with regular ones.Idiopathic VAs can be ablated via the CVS in conjunction with endocardial mapping. Additionally, spiky fractionated long-duration potential can function as a clue to identify the good ablation site.

Published
2016

174. Risk of Cardiovascular Ischemic Events After Surgical Castration and Gonadotropin-Releasing Hormone Agonist Therapy for Prostate Cancer: A Nationwide Cohort Study

Author

Chen, Dong-Yi, primary, See, Lai-Chu, additional, Liu, Jia-Rou, additional, Chuang, Cheng-Keng, additional, Pang, See-Tong, additional, Hsieh, I-Chang, additional, Wen, Ming-Shien, additional, Chen, Tien-Hsing, additional, Lin, Yung-Chang, additional, Liaw, Chuang-Chi, additional, Hsu, Cheng-Lung, additional, Chang, John Wen-Cheng, additional, Kuo, Chang-Fu, additional, and Huang, Wen-Kuan, additional

Published
2017
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175. A genome-wide association study links small-vessel ischemic stroke to autophagy

Author

Lee, Tsong-Hai, primary, Ko, Tai-Ming, additional, Chen, Chien-Hsiun, additional, Chang, Yeu-Jhy, additional, Lu, Liang-Suei, additional, Chang, Chien-Hung, additional, Huang, Kuo-Lun, additional, Chang, Ting-Yu, additional, Lee, Jiann-Der, additional, Chang, Ku-Chou, additional, Yang, Jen-Tsung, additional, Wen, Ming-Shien, additional, Wang, Chao-Yung, additional, Chen, Ying-Ting, additional, Chen, Tsai-Chuan, additional, Chou, Shu-Yu, additional, Lee, Ming-Ta Michael, additional, Chen, Yuan-Tsong, additional, and Wu, Jer-Yuarn, additional

Published
2017
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176. Predictors of subsequent myocardial infarction, stroke, and death in stable post-myocardial infarction patients: A nationwide cohort study

Author

Chen, Dong-Yi, primary, Li, Chen-Yu, additional, Hsieh, Ming-Jer, additional, Chen, Chun-Chi, additional, Hsieh, I-Chang, additional, Chen, Tien-Hsing, additional, Chen, Shao-Wei, additional, Wang, Chao-Yung, additional, Chang, Shang-Hung, additional, Lee, Cheng-Hung, additional, Tsai, Ming-Lung, additional, Ho, Ming-Yun, additional, Yeh, Jih-Kai, additional, Chang, Chee-Jen, additional, and Wen, Ming-Shien, additional

Published
2017
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179. Pharmacogenetic dosing of warfarin in the Han-Chinese population: a randomized trial

Author

Wen, Ming-Shien, primary, Chang, Kuan-Cheng, additional, Lee, Tsong-Hai, additional, Chen, Ying-Fu, additional, Hung, Kuo-Chun, additional, Chang, Yeu-Jhy, additional, Liou, Chia-Wei, additional, Chen, Jin-Jer, additional, Chang, Chien-Hung, additional, Wang, Chao-Yung, additional, Jeng, Jiann-Shing, additional, Chuang, Hui-Ping, additional, Chen, Ying-Ting, additional, Chen, Chien-Hsiun, additional, Wu, Jer-Yuarn, additional, Chen, Yuan-Tsong, additional, and Lee, Ming Ta Michael, additional

Published
2017
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180. Imaging of Cardiac and Pericardial Masses

Author

Wu, Patricia Wanping, primary, Chen, Shyh-Jye, additional, Lin, Wan-Ching, additional, Chang, Chun-Bi, additional, Chuang, Wen-Yu, additional, Hsu, Ming-Yi, additional, Liu, Yuan-Chang, additional, Chu, Jaw-Ji, additional, Lin, Pyng-Jing, additional, Wen, Ming-Shien, additional, Hung, Kuo-Chun, additional, and Wan, Yung-Liang, additional

Published
2017
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184. Effects of adenosine on paroxysmal atrial tachycardia

Author

Hsieh, I-Chang, Yeh, San-Jou, Wen, Ming-Shien, Wang, Chun-Chieh, Lin, Fun-Chung, and Wu, Delon

Subjects
Adenosine triphosphatase -- Evaluation, Paroxysmal tachycardia -- Drug therapy, Heart atrium -- Abnormalities, Health
Published
1994

186. Risk Factors Influencing Complications of Cardiac Implantable Electronic Device Implantation: Infection, Pneumothorax and Heart Perforation

Author

Lin, Yu-Sheng, Hung, Sheng-Ping, Chen, Pei-Rung, Yang, Chia-Hung, Wo, Hung-Ta, Chang, Po-Cheng, Wang, Chun-Chieh, Chou, Chung-Chuan, Wen, Ming-Shien, Chung, Chang-Ming, and Chen, Tien-Hsing

Subjects
Adult, Aged, 80 and over, Male, Pacemaker, Artificial, Incidence, Taiwan, Observational Study, Pneumothorax, Middle Aged, Infections, Article, Defibrillators, Implantable, Young Adult, Heart Injuries, Risk Factors, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, Female, Aged, Retrospective Studies
Abstract

Supplemental Digital Content is available in the text, As the number of cardiac implantable electronic devices (CIEDs) is increasing annually, CIED-related complications are becoming increasingly important. The aim of the study was to assess the risks associated with CIEDs by a nationwide database. Patients were selected from the Taiwan National Health Insurance Database. Admissions for CIED implantation, replacement, and revision were evaluated and the evaluation period was 14 years. Endpoints included CIED-related infection, pneumothorax, and heart perforation. The study included 40,608 patients with a mean age of 71.8 ± 13.3 years. Regarding infection, the incidence rate was 2.45 per 1000 CIED-years. Male gender, younger age, device replacement, and previous infection were risks for infection while old age and high-volume centers (>200 per year) were protectors. The incidence of pneumothorax was 0.6%, with an increased risk in individuals who had chronic obstructive lung disease (COPD) and cardiac resynchronized therapy (CRT). The incidence of heart perforation was 0.09%, with an increased risk in individuals who had pre-operation temporal pacing and steroid use. High-volume center was found to decrease infection rate while male gender, young people, and individuals who underwent replacements were associated with an increased risk of infection. Additionally, pre-operation temporal pacing and steroid use should be avoided if possible. Furthermore, COPD patients or those who accept CRTs should be monitored closely.

Published
2014

187. Current Status and Perspectives in Stem Cell Therapy for Heart

Author

Lin, Fen-Chiung, Chen, Wen-Pin, Chu, Pao-Hsien, Shyu, Kou-Gi, and Wen, Ming-Shien

Subjects
Mini Forum for Cardiovascular Stem Cell
Abstract

For most patients, the prognosis of heart failure remains poor despite therapeutic advancement in recent decades. The option of cardiac transplantation is high risk and limited by a shortage of donors. Traditionally, the heart had been considered a terminally differentiated organ incapable of regeneration. However, numerous preclinical and clinical studies have been performed since the first report of cell therapy in heart failure using skeletal myoblasts in 2001. These investigations looked at the promising potential and use of several kinds of stem cells, which could some day dramatically alter the understanding of the regenerative capacity of the heart. To date, although there is no existing cardiac cell therapy that has been conclusively reported to be effective, stem cell-related cardiomyocyte regeneration strategies have become significant areas of research in modern cardiovascular medicine. In this review, we outline a variety of common cell sources, surface biomarkers of stem cells, and provide information related to cardiac cell therapy clinical trials.Clinical trial; Stem cell.

Published
2014

188. Long-Term Survival of Multicenter Automatic Defibrillator Implantation Trial (MADIT) II-Eligible Patients in Taiwan

Author

Chang*, Po-Cheng, Chen*, Wei-Ting, Wo, Hung-Ta, Chen, Tien-Hsing, Wen, Ming-Shien, Yeh, San-Jou, and Wang, Chun-Chieh

Subjects
Original Article
Abstract

he Multicenter Automatic Defibrillator Implantation Trial (MADIT) II showed that use of a prophylactic implantable cardioverter defibrillator (ICD) improved the survival of patients with poor left ventricular ejection fraction after myocardial infarction. The major concerns about primary ICD prevention in Asian countries are the long-term survival and the incidence of sudden cardiac death. Whether long-term outcomes within the Taiwanese population are comparable to the MADIT II trial remains unclear.We retrospectively reviewed the clinical records of 1909 inpatients who had both myocardial infarction and heart failure in the discharge diagnoses from Jan. 2001 through Dec. 2006, and 313 patients without ICD implantation who satisfied the MADIT II criteria were included for survival analysis.After 4.60 ± 4.31 years of follow-up, 152 (49%) patients had died. Of these patients, 68 (45%) died of sudden cardiac death, similar to the conventional group (patients without ICD implantation) in the MADIT II study (51%). The Kaplan-Meier curve showed that survival during the first two years in this cohort was inferior to the conventional group of the MADIT II population. After two years, the survival curve was similar to the conventional group but still inferior to the defibrillator group in the MADIT II study. Multivariate Cox regression analysis showed old age and blood urea nitrogen25 mg/dL were independent predictors of mortality. A history of percutaneous coronary intervention was associated with lower mortality.The long-term outcomes of Taiwanese patients who are eligible within MADIT II criteria are similar to the conventional group in the MADIT II study.Heart failure; Implantable cardioverter defibrillator; Myocardial infarction; Sudden cardiac death.

Published
2014

189. 2016 Guidelines of the Taiwan Heart Rhythm Society and the Taiwan Society of Cardiology for the management of atrial fibrillation

Author

Chiang, Chern-En, primary, Wu, Tsu-Juey, additional, Ueng, Kwo-Chang, additional, Chao, Tze-Fan, additional, Chang, Kuan-Cheng, additional, Wang, Chun-Chieh, additional, Lin, Yenn-Jiang, additional, Yin, Wei-Hsian, additional, Kuo, Jen-Yuan, additional, Lin, Wei-Shiang, additional, Tsai, Chia-Ti, additional, Liu, Yen-Bin, additional, Lee, Kun-Tai, additional, Lin, Li-Jen, additional, Lin, Lian-Yu, additional, Wang, Kang-Ling, additional, Chen, Yi-Jen, additional, Chen, Mien-Cheng, additional, Cheng, Chen-Chuan, additional, Wen, Ming-Shien, additional, Chen, Wen-Jone, additional, Chen, Jyh-Hong, additional, Lai, Wen-Ter, additional, Chiou, Chuen-Wang, additional, Lin, Jiunn-Lee, additional, Yeh, San-Jou, additional, and Chen, Shih-Ann, additional

Published
2016
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191. The Obesity-Mortality Paradox in Patients With Heart Failure in Taiwan and a Collaborative Meta-Analysis for East Asian Patients

Author

Lin, Gen-Min, primary, Li, Yi-Hwei, additional, Yin, Wei-Hsian, additional, Wu, Yen-Wen, additional, Chu, Pao-Hsien, additional, Wu, Chih-Cheng, additional, Hsu, Chih-Hsin, additional, Wen, Ming-Shien, additional, Voon, Wen-Chol, additional, Wang, Chun-Chieh, additional, Yeh, San-Jou, additional, Lin, Wei-Shiang, additional, Chan, Kuei-Chuan, additional, Chang, Heng-Chia, additional, Chang, Kuan-Cheng, additional, Chen, Zhih-Cherng, additional, Chen, Shyh-Ming, additional, Huang, Jin-Long, additional, Kuo, Jen yuan, additional, Lin, Jiunn-Lee, additional, Mar, Guang-Yuan, additional, Shyu, Kou-Gi, additional, Sung, Shih-Hsien, additional, Tseng, Wei-Kung, additional, Wang, Ji-Hung, additional, and Yang, Ning-I., additional

Published
2016
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193. Benefits of Intraaortic Balloon Support for Myocardial Infarction Patients in Severe Cardiogenic Shock Undergoing Coronary Revascularization

Author

Mao, Chun-Tai, primary, Wang, Jian-Liang, additional, Chen, Dong-Yi, additional, Tsai, Ming-Lung, additional, Lin, Yu-Sheng, additional, Cherng, Wen-Jin, additional, Wang, Chao-Hung, additional, Wen, Ming-Shien, additional, Hsieh, I-Chang, additional, Hung, Ming-Jui, additional, Chen, Chun-Chi, additional, and Chen, Tien-Hsing, additional

Published
2016
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194. Clinical outcomes of drug-eluting stents versus bare-metal stents in patients with cardiogenic shock complicating acute myocardial infarction

Author

Chen, Dong-Yi, primary, Mao, Chun-Tai, additional, Tsai, Ming-Lung, additional, Chen, Shao-Wei, additional, Lin, Yu-Sheng, additional, Hsieh, I-Chang, additional, Hung, Ming-Jui, additional, Wang, Chao-Hung, additional, Wen, Ming-Shien, additional, Cherng, Wen-Jin, additional, and Chen, Tien-Hsing, additional

Published
2016
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198. A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients: a population-based dynamic cohort study in Taiwan

Author

Wu, Lung-Sheng, primary, Chang, Shang-Hung, additional, Chang, Gwo-Jyh, additional, Liu, Jia-Rou, additional, Chan, Yi-Hsin, additional, Lee, Hsin-Fu, additional, Wen, Ming-Shien, additional, Chen, Wei-Jan, additional, Yeh, Yung-Hsin, additional, Kuo, Chi-Tai, additional, and See, Lai-Chu, additional

Published
2016
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199. Identification of PTCSC3 as a Novel Locus for Large‐Vessel Ischemic Stroke: A Genome‐Wide Association Study

Author

Lee, Tsong‐Hai, primary, Ko, Tai‐Ming, additional, Chen, Chien‐Hsiun, additional, Lee, Ming‐Ta Michael, additional, Chang, Yeu‐Jhy, additional, Chang, Chien‐Hung, additional, Huang, Kuo‐Lun, additional, Chang, Ting‐Yu, additional, Lee, Jiann‐Der, additional, Chang, Ku‐Chou, additional, Yang, Jen‐Tsung, additional, Wen, Ming‐Shien, additional, Wang, Chao‐Yung, additional, Chen, Ying‐Ting, additional, Hsieh, Chia‐San, additional, Chou, Shu‐Yu, additional, Liu, Yi‐Min, additional, Chen, Hui‐Wen, additional, Liao, Hung‐Ting, additional, Wang, Chia‐Wen, additional, Chen, Shih‐Ping, additional, Lu, Liang‐Suei, additional, Chen, Yuan‐Tsong, additional, and Wu, Jer‐Yuarn, additional

Published
2016
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