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408 results on '"White, Gilbert C."'

154. The recombinant factor IX clinical investigator group’s response to Dr Haase

Author

Roth, David A., Kessler, Craig M., Pasi, K. John, Ragni, Margaret V., White, Gilbert C., II, Giangrande, Paul L., Blanchette, Victor S., Brackmann, Hans-Hermann, Heisel, Margaret A., Hoots, W. Keith, Lee, Christine, Ludlam, Christopher A., Lusher, Jeanne M., Negrier, Claude, Philipp, Christine, Lee, Claire, Poon, Man-Chiu, Rivard, Georges E., Rosenfield, Cathy G., Shapiro, Amy, Thomas, Angela, Thompson, Arthur R., and Vermylen, Jozef

Published
2002

164. Human Immunodeficiency Virus (HIV) Type 1 Infection Status and In Vitro Susceptibility to HIV Infection among High-Risk HIV-I-Seronegative Hemophiliacs

Author

Lederman, Michael M., Jackson, J. Brooks, Kroner, Barbara L., White, Gilbert C., Eyster, M. Elaine, Aledort, Louis M., Hilgartner, Margaret W., Kessler, Craig M., Cohen, Alan R., Kiger, Kevin P., and Goedert, James J.

Abstract

Blood samples were obtained from 16 hemophiliacs who had a 50%–94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P < .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%–56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.

Published
1995
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165. Failure of Activated Prothrombin Complex Concentrates in a Hemophiliac With an Anti-Factor VIII Antibody

Author

Blatt, Philip M., White, Gilbert C., McMillan, Campbell W., and Webster, William P.

Abstract

IN APPROXIMATELY 15% of patients with severe hemophilia A who receive multiple transfusions, anti— factor VIII antibodies develop (C. W. McMillan, MD, S. S. Shapiro, MD, J. Lazerson, MD, unpublished data, 1983). Control of hemorrhagic episodes in these patients is often difficult and unsatisfactory. Various methods of treatment have been developed for such patients.1,2 Most recently, activated prothrombin complex concentrates (PCCs) have been described as efficacious in controlling hemorrhage in patients with an inhibitor. Two preparations of activated PCC have been developed: Autoplex (anti-inhibitor coagulant complex) and FEIBA (factor eight inhibitor bypassing activity). In published trials, response to treatment with Autoplex for major and minor bleeds ranged from excellent to fair with no treatment failures,2 while FEIBA was judged to be effective in control of joint and muscle bleeding in 64% of treatment episodes.3 The purpose of this report is to describe the failure of Autoplex to

Published
1984
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166. Mechanisms of B-cell Tolerance

Author

Jacquemin, Marc G., Vanzieleghem, Beatrijs, Saint-Remy, Jean-Marie R., Monroe, Dougald M., editor, Hedner, Ulla, editor, Hoffman, Maureane R., editor, Negrier, Claude, editor, Savidge, Geoffrey F., editor, and White, Gilbert C., II, editor

Published
2001
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172. Factor Viii Inhibitors

Author

Lollar, Pete, Healey, John F., Barrow, Rachel T., Parker, Ernest T., Monroe, Dougald M., editor, Hedner, Ulla, editor, Hoffman, Maureane R., editor, Negrier, Claude, editor, Savidge, Geoffrey F., editor, and White, Gilbert C., II, editor

Published
2001
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174. Factor V: Dr. Jeckyll and Mr. Hyde

Author

Kalafatis, Michael, Mann, Kenneth G., Monroe, Dougald M., editor, Hedner, Ulla, editor, Hoffman, Maureane R., editor, Negrier, Claude, editor, Savidge, Geoffrey F., editor, and White, Gilbert C., II, editor

Published
2001
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183. Apheresis

Author

Nilsson, Inga Marie, Freiburghaus, Christian, Aledort, Louis M., editor, Hoyer, Leon W., editor, Lusher, Jeanne M., editor, Reisner, Howard M., editor, and White, Gilbert C., II, editor

Published
1995
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196. B-cell epitopes:Fact and fiction

Author

Benjamin, David C., Aledort, Louis M., editor, Hoyer, Leon W., editor, Lusher, Jeanne M., editor, Reisner, Howard M., editor, and White, Gilbert C., II, editor

Published
1995
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197. Antigen analogs as therapeutic agents

Author

Alexander, Jeff, Ruppert, Jörg, Page, Dawne M., Hedrick, Stephen M., Franco, Alessandra, Ishioka, Glenn Y., Grey, Howard M., Sette, Alessandro, Aledort, Louis M., editor, Hoyer, Leon W., editor, Lusher, Jeanne M., editor, Reisner, Howard M., editor, and White, Gilbert C., II, editor

Published
1995
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