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Nanomaterials are threatening the environment and human health, but there has been little discussion about the stability and mobility of nanoparticles (NPs) in saturated porous media at environmentally relevant concentrations of surfactants, which is a knowledge gap in exploring the fate of engineered NPs in groundwater. Therefore, the influences of the anionic surfactant (sodium dodecylbenzene sulfonate, SDBS), the cationic surfactant (cetyltrimethylammonium bromide, CTAB), and the nonionic surfactant (Tween-80) with environmentally relevant concentrations of 0, 5, 10, and 20 mg/L on nano-TiO

Chemical and biological sensors have attracted great interest due to their importance in applications of healthcare, food quality monitoring, environmental monitoring, etc. Carbon nanotube (CNT)-based field-effect transistors (FETs) are novel sensing device configurations and are very promising for their potential to drive many technological advancements in this field due to the extraordinary electrical properties of CNTs. This review focuses on the implementation of CNT-based FETs (CNTFETs) in chemical and biological sensors. It begins with the introduction of properties, and surface functionalization of CNTs for sensing. Then, configurations and sensing mechanisms for CNT FETs are introduced. Next, recent progresses of CNTFET-based chemical sensors, and biological sensors are summarized. Finally, we end the review with an overview about the current application status and the remaining challenges for the CNTFET-based chemical and biological sensors.

Polylactic acid (PLA) is biodegraded rapidly under composting or thermophilic temperature but slowly under natural conditions with substantial microplastics generated. In this study, we examined the feasibility of PLA biodegradation and developed a novel approach for PLA waste management using yellow mealworms (Tenebrio molitor larvae) to achieve biodegradation and resource recovery simultaneously. Results confirmed PLA biodegradation in mealworms as sole PLA and PLA-bran mixtures (10%, 20%, 30% and 50% PLA, wt/wt). Feeding PLA-bran mixtures supported the larval development with higher survival rates and lower cannibal rates than feeding PLA only at ambient temperature. The PLA conversion efficiency was 90.9% with 100% PLA diet and was around 81.5–86.9% with PLA-bran mixtures. A peak insect biomass yield was achieved at a PLA ratio of 20%. PLA biodegradation was verified via detection of chemical and thermal modifications. Gut microbial community analysis indicated that intestinal communities shifted with PLA biodegradation, resulting in clusters with OTUs unique to the PLA diet. Based on these findings, we propose a circular approach for PLA waste management via resource recovery of used PLA as the feedstock for insect biomass production, management of mealworm excrement waste as fertilizer, and utilization of agricultural products for PLA production.

This paper describes how the maximum blur radius affects the depth results by depth from the defocus (DFD) method based on liquid crystal (LC) lens. Boundary frequency is determined by the maximum blur radius. It is found that if the maximum blur radius used in the calculation is larger than the real value, the depth resolution obtained is reduced; on the other hand, if one smaller than the real value is used, the depth resolution in the middle range of the scene is increased, but errors occur in the near and far planes. Using the maximum blur radius close to the real one results in the best depth results.

Anaerobic digestion of pharmaceutical wastewater is challenged by its contained toxic compounds which limits the stability and efficiency of methane production and organic degradation. In this study, zero valent iron (ZVI) and granular activated carbon (GAC) were added with different strategies to improve anaerobic digestion of pharmaceutical wastewater. The results confirmed synergy effects of ZVI + GAC for both COD removal (increased by 13.4%) and methane production (increased by 11.0%). Furthermore, ZVI + GAC improved the removal of pharmaceutical intermediates, in particular, the residues (%) of dehydroepiandrosterone (DHEA) and 2,2'-methylenebis(6-tert-butyl-4-methylphenol) were only 30.48 ± 6.53 and 39.92 ± 4.50, and effectively reduced biotoxicity. The promoted results were attributed to the establishment of direct interspecies electron transfer (DIET). Microbial community analysis revealed that ZVI + GAC decreased species evenness and richness in bacterial whereas increased in archaeal. The relative abundance of acetotrophic methanogens decreased but hydrogenotrophic and methylotrophic methanogens increased, which broadening the pathway of methane production.

To improve advanced oxidation processes (AOPs), bio-inspired iron-encapsulated biochar (bio-inspired Fe⨀BC) catalysts with superior performance were prepared from iron-rich biomass of Iris sibirica L. using a pyrolysis method under anaerobic condition. The obtained compounds were used as catalysts to activate perdisulfate (PDS) and then degradate 2,4-dichlorophenol (2,4-DCP), and synthetic iron-laden biochar (synthetic Fe-BC) was used for comparison. The highest removal rate of 2,4-DCP was 98.35%, with 37.03% of this being distinguished as the contribution of micro-electrolysis, greater than the contribution of adsorption (32.81%) or advanced oxidation (28.51%). The high performance of micro-electrolysis could be attributable to the formation of Fe (Iron, syn) and austenite (CFe15.1) with strong electron carrier at 700 °C. During micro-electrolysis, Fe2+ and electrons were gradually released and then used as essential active components to enhance the AOPs. The slow-releasing Fe2+ (K = 0.0048) also inhibited the overconsumption of PDS (K = −0.00056). Furthermore, the electrons donated from Fe⨀BC-4 were able to activate PDS directly. The electrons were enriched by the porous structure of Fe⨀BC-4, and the formation of the C O Fe bond in the π-electron system could also accelerate the electron transfer to activate PDS. Similar reactive oxygen species (ROS) were identified during the micro-electrolysis and AOPs, leading to similar degradation pathways. The higher does concentration of O2− generated during micro-electrolysis than during the AOPs also led to a greater dechlorination effect.

In order to meet the increasing demand of customers for car quality and interior environment, Changan Automobile has carried out innovative research on the traditional car wax injection process, jointly developed a new environmentally friendly cavity wax, and adopted a precise wax injection process to reduce the smell of the car. VOC, to enhance anti-corrosion performance, and promote the application of innovative automotive wax injection technology in various bases of Changan Automobile, and practice the concept of “fully promoting green manufacturing and increasing advanced energy-saving and environmental protection technology” in “Made in China 2025”.

Partial hydrogenolysis of erythritol, which can be produced at large scale by fermentation, to 1,4-butanediol (1,4-BuD) is investigated with Ir-ReO

To solve the problem of organic and inorganic arsenic species contamination in drinking water and/or wastewater, porous biochar-supported MnFe

The application of phenylurea herbicides (PUHs) may lead to the extensive distribution in soils, while the role of straw biochar as a soil amendment on the transport and sorption of PUHs are still unclear. Thus, the transport and sorption behavior of three typical PUHs with rice straw biochar (RSB) was studied in both adsorption simulation experiments of aqueous solution and packed column experiments. The sorption mechanism of RSB to herbicides was investigated through batch sorption studies with three influencing factors including dosage of RSB, pH, and ionic strength (IS) with orthogonal test. The sorption coefficients were improved significantly by increasing the dosage of RSB, while there was no obvious influence by enhancing the pH and IS value. The optimal sorption conditions (pH value at 3, IS at 0.1 M, and RSB dosage at 60 mg) of three herbicides were set and the maximum removal rates of Monuron, Diuron, and Linuron were 41.9%, 25%, and 56.8%, respectively. The co-transport process of RSB and PUHs were investigated under different RSB dosage, pH value, and IS value. The retention effect increased greatly with enhancing the RSB dosage and pH value. However, IS did not have a significant influence on the retention of RSB, and therefore it had little effect on the adsorption capacity, which was consistent with the results of sorption experiments. The breakthrough curves (BTCs) for co-transport were well simulated by the two-site non-equilibrium convection–dispersion equation (CDE). Most of the regression coefficients (R2) were above 0.99, which uncovered the co-transport in packed column were affected by physical absorption and chemical forces. According to the fitting parameters analysis, the RSB particles and PUHs were subjected to a greater resistance and a stronger stability by reducing pH value in porous media. The presence of RSB increased the amount of dynamic sorption sites in the entire co-transport system, which led to a significant promotion of the PUHs' sorption and interception.

A series of ordered mesoporous Fe Mn bimetal oxides (OMFMs) were fabricated by using a novel inverse micelle method, and the texture, nanostructure and interface chemistry properties of OMFMs were closely correlated to the calcination temperature. Due to the amorphous regular inner-connected nanostructure and bimetallic synergistic effect, the obtained OMFMs exhibited superior arsenic sequestration performance than pure mesoporous Fe oxides (PMF) and Mn oxides (PMM). The optimum ratio of Fe/Mn and calcination temperature for arsenic removal was 3/1 and 350 °C (OMFM-3), and the maximum As(III) and As(V) adsorption capacities of OMFM-3 were 174.59 and 134.58 mg/g, respectively. Solution pH value negligibly affected the uptake of arsenic (ranged from 3.0 to 7.0), while SiO32−/PO43− ions and humic acid (HA) displayed significant inhibitory effect on arsenic removal by OMFM-3. According to the mechanism of arsenic removal, which simultaneously analyzed the arsenic redox transformation in aqueous phase and on solid phase interface, it was concluded that manganese oxides in OMFM-3 mainly played the role as a remarkable As(III) oxidant in water, whereas iron oxides dominantly acted as an excellent arsenic species adsorbent. Finally, the prominent arsenic sequestration behavior and performance in surface water suggested that OMFM-3 could be a promising and hopeful candidate for arsenic-contaminated (especially As(III)) surface water and groundwater remediation and treatment.

Magnetite is known to exhibit high catalytic reactivity in Fenton-like reactions merely at low pH conditions. Here we report the association of Cu2+ ion can significantly enhance peroxydisulfate (PDS) activation with magnetite under environmental aquatic conditions (near neutral pH). Cu2+ is able to synergistically activate PDS with magnetite to generate radicals, e.g., SO4·−, at neutral or slightly alkaline pH, and such synergistic activation of PDS is promising to degrade various contaminants in groundwater. In-depth study reveals Cu2+ ion adsorbed on magnetite plays a crucial role in PDS activation. The adsorbed Cu2+ is labile to be reduced by the structural Fe(II) on magnetite to generate Cu+, which is relatively stable in the presence of magnetite at neutral or alkaline pH, but extremely unstable at acidic pH. The generated Cu+ on magnetite surface, rather than Cu2+, contributes to PDS activation in the reaction system, and the recycling of Cu+/Cu2+ sustains continuous activation of PDS. This study is among the first to report the synergistic activation of PDS by magnetite and Cu2+ ion at neutral pH, and unambiguously discern the role of Cu+ in PDS activation. The new mechanistic knowledge provides a more accurate understanding of PDS activation by natural minerals in environmental remediation.

The development of new sensing platforms could offer exciting opportunities for healthcare and environmental applications. In the last few decades, sensor device configurations have been limited owing to the use of electrochemical electrodes, resistors, and transistors. Capacitors are widely used for constructing various electronic devices. Here, we report for the first time the construction of a transparent interdigital transparent capacitor and its use for sensing ethanol. When the ethanol concentration changes, the dielectric properties of the capacitor change, resulting in the response of the impedance and capacitance. The capacitor shows a detection range of 0.1–1 volume fraction. It is expected that this paper could open up new opportunities for fundamental studies of more complex sensor configurations with a capacitor as one of the components and advance related healthcare and environmental applications.

There has been a developing technology in algae with pharmaceuticals wastewater. However, the effect and the underlying mechanism of pharmaceuticals on algae are not well understood. To investigate the effect and mechanism of pharmaceuticalson microalgae, four pharmaceuticals of clofibric acid (CLF), ciprofloxacin (CIP), diclofenac (DCF) and carbamazepine (CBZ) on C. pyrenoidosa culture were analyzed. At low concentrations (a accumulation, lipid accumulation) and activities of antioxidant enzymes were stimulated. The algal metabolite differences of various DCF concentrations were investigated and a total of 91 substances were identified, whose samples were clustered and clearly separated. The key metabolomics pathway analysis found that the DCF promoted the carbohydrate and fatty acid metabolic pathway in C. pyrenoidosa under relatively low concentrations (100 mg/L). The study detected the effects of four pharmaceuticals on C. pyrenoidosa and demonstrated that the usage of metabolomics analysis complemented with DCF could be an effective approach to understand the mechanism of molecular evolution in C. pyrenoidosa for microalgal biomass and bioenergy from wastewater in researches of biological resources.

Tenebrio molitor larvae (Coleoptera: Tenebrionidae) are capable of depolymerizing and biodegrading polystyrene and polyethylene. We tested for biodegradation of Polyvinyl Chloride (PVC) in T. molitor larvae using rigid PVC microplastic powders (MPs) (70–150 μm) with weight-, number-, and size-average molecular weights (Mw, Mn and Mz) of 143,800, 82,200 and 244,900 Da, respectively, as sole diet at 25 °C. The ingestion rate was 36.62 ± 6.79 mg MPs 100 larvae-1 d-1 during a 16-day period. The egested frass contained about 34.6% of residual PVC polymer, and chlorinated organic carbons. Gel permeation chromatography (GPC) analysis indicated a decrease in the Mw, Mn and Mz by 33.4%, 32.8%, and 36.4%, respectively, demonstrating broad depolymerization. Biodegradation and oxidation of the PVC MPs was supported by the formation of O C and O C functional groups using frontier transform infrared spectroscopy (FTIR) and 1H nuclear magnetic resonance (1H NMR), and by significant changes in the thermal characteristics using thermo-gravimetric analysis (TGA). Chloride released was counted as about 2.9% of the PVC ingested, indicating limited mineralization of the PVC MPs. T. molitor larvae survived with PVC as sole diet at up to 80% over 5 weeks but did not complete their life cycle with a low survival rate of 39% in three months. With PVC plus co-diet wheat bran (1:5, w/w), they completed growth and pupation as same as bran only in 91 days. Suppression of gut microbes with the antibiotic gentamicin severely inhibited PVC depolymerization, indicating that the PVC depolymerization/biodegradation was gut microbe-dependent. Significant population shifts and clustering in the gut microbiome and unique OTUs were observed after PVC MPs consumption. The results indicated that T. molitor larvae are capable of performing broad depolymerization/biodegradation but limited mineralization of PVC MPs.

Fabrication of few-layered polymeric carbon nitride (PCN) photocatalysts have attracted increasing attention owing to their substantial enhancement of the photocatalytic performance. A green strategy for the synthesis of ultrathin PCN nanosheets with integration of high-efficiency and enriched active edges using minimimal chemicals and energy input is overwhelmingly required and is still challenging. Herein, we report a green, cost-effective and template-free synthesis approach for ultrathin foam-like PCN nanosheets with enriched active sites in a wet atmosphere via a “three-in-one” strategy. This strategy relies on coupling of melem segments, polymerization with condensed layers, delamination by water molecules, and introduction of new terminal groups entirely in one-pot without any other additives. The obtained melem-derived PCN (MFCN-wet) shows highly loose and extremely light characteristics with the formation of ultrathin few-layers. Furthermore, it exhibits a high specific surface area and pore volume. Most importantly, the enriched active sites with fast charge carrier transfer drastically enhance the hydrogen evolution rate and rhodamine B (RhB) degradation with a high stability under visible light irradiation, compared with that of the as-synthesized materials in nitrogen and air atmospheres. This sustainable strategy could provide new opportunities for further environmental and energy applications.

A novel strategy for the synthesis of 2-arylated oxazole derivatives via palladium/copper-catalyzed decarbonylative heteroarylation of amides via C–N bond activation by ground-state destabilization is reported. This transformation shows good functional group tolerance and delivers the versatile 2-arylated oxazole derivatives in moderate to good yields. This transformation provides unique and efficient strategies for converting readily available amides and the precursor carboxylic acids into valuable chemicals.

Peroxymonosulfate (PMS) is an appealing oxidant for organic contaminant destruction relying on radical generation after activation. Herein, we report PMS-promoted rapid degradation of histamine H

Vibration membrane filtration has been confirmed as an effective method to improve algae separation from water. However, the fouling evolution process and the antifouling mechanism are not well understood. In this study, a novel hybrid method based on a dynamics model was proposed, a comprehensive evaluation was conducted, and the critical vibration frequency for accurate analysis and prediction of membrane fouling was developed. The dynamics model was studied with an improved collision-attachment model by considering all the concurrent and synergistic effects of the hydrodynamic interactions acting on algae. From the perspective of potential energy, the improved model systematically elucidated the reason why the antifouling performance was enhanced when the vibration frequency varied from 1 Hz to 5 Hz. In addition, the Technique for Order Preference by Similarity to Ideal Solution-grey relational analysis (TOPSIS-GRA) method with combined weights was incorporated for the first time to provide direct comprehensive evaluation evidence to determine the effect of the vibration frequency on membrane fouling. It was found that increasing the vibration frequency could not alleviate membrane fouling caused by extracellular organic matter. Moreover, the concept of a critical vibration frequency was proposed using genetic algorithm optimized back propagation neural network, and the energy consumption was analyzed. This combination could provide an effective means to choose the most appropriate vibration frequency, thereby improving the efficiency of the vibration membrane system in the algae separation process.

There is growing pressure for wastewater treatment plants to mitigate the discharge of antibiotic resistant bacteria (ARB) and extracellular resistance genes (eARGs), which requires technological innovation. Here, hierarchical Bi

Background This study is aimed to unravel the genetic factors associated with microRNA (miRNA) expression in regulating sex‐determining region Y‐box 2 (SOX2)‐mediated cisplatin resistance in small‐cell lung cancer (SCLC). Methods The relevance of SOX2 expression in SCLC was analyzed in a panel of SCLC cells by quantitative real‐time PCR (qPCR) and western blot (WB). We selected DMS114 cell line, in which SOX2 was amplified via lentiviral vector‐mediated transfection of the SOX2 genes and tested for the half‐maximal inhibitory concentration (IC50) by MTS assay. High‐throughput sequencing and screening of differentially expressed miRNAs between SOX2‐overexpressing and normal control cells were performed. Finally, miRanda software was used to verify the miRNAs bound with SOX2 and qPCR was used to identify the expression of miRNAs which were binding with SOX2. Results Cisplatin‐resistant SOX2‐overexpressing DMS114 cell lines were successfully developed, showing a statistically significant increase in SOX2 expression by qPCR and WB. Our results showed a typically higher IC50 value in SOX2‐overexpressing cells compared with the negative controls. The high‐throughput sequencing analysis revealed that 68 miRNAs were upregulated and 24 miRNAs were downregulated in the SOX2‐overexpressing cells. The 24 downregulated miRNAs were further verified. Of them, a cancer‐related miRNA, hsa‐miR‐340‐5p, showed a higher binding affinity with SOX2 in network regulation mapping, which was also found to be markedly downregulated under qPCR analysis. Conclusion We demonstrated that downregulated expression of hsa‐miR‐340‐5p may affect cisplatin resistance by mediating SOX2 expression in SCLC cells, which may provide a potential target for the therapy of chemoresistant SCLCs., In this study, we aimed to unravel the genetic factors associated with miRNA expression in regulating the SOX2‐mediated cisplatin resistance in SCLC. Cisplatin‐resistant SOX2 overexpressing DMS114 cell lines were successfully developed, which showed a statistically significant increase in SOX2 expression by qPCR and western blot.

The indoor environments of severely polluted toilets are associated with an increased risk of transmission of severe diseases. Enhancing the ventilation effectiveness can improve the indoor air quality (IAQ). The characteristics of pollutant transmission in a public toilet model were analyzed using a computational fluid dynamic program and were further validated based on experimental measurements using a tracer gas (SF6). This study investigated the typical pollutant (ammonia and hydrogen sulfide) diffusion characteristics, relationship between the number of air changes per hour and concentration of pollutants, and personal exposure under two types of typical ventilation systems—mixing ventilation (MV) and personalized ventilation (PV)—in public toilets. The results show that MV can reduce the concentration of pollutants in the toilet, but the IAQ cannot reach the desired level. Under a constant total ventilation rate, PV can effectively remove pollutants in the toilet and reduce the concentration of pollutants in the breathing area. The results of this study can contribute to improving the IAQ of public toilets.

The development of a new sensing procedure for protein could open up significant opportunities for the detection of a variety of biomarkers in healthcare. Here, a new detection procedure called dry sensing was invented for the detection of bovine serum albumin (BSA), and its performance was studied and compared with a wet sensing procedure with a flexible graphene sensor. Both detection methods show a highly sensitive detection of BSA: a typical protein. Wet sensing shows a broader detection range of 5.88E-06 to 2.07E-04 (wv), but the sensing signal is not stable and consistent. Further, its detection time can be as long as more than 10min (due to the long drifting time of the signal). Dry sensing shows a broad detection as well from 0.01 to 0.1 (wv), though it's narrower than that of wet sensing. Since dry sensing avoids the drifting of an electrical signal, the signal is more stable and consistent, and the detection time can be controlled with 1min. The current method could lead to significant progress for sensing a variety of analytes based on antigenantibody binding or DNA hybridization.

A uniform shearing vibration membrane system can mitigate membrane fouling during algae filtration. In this paper, the effects of transmembrane pressure (TMP) on the membrane filtration performance at 8 kPa, 9 kPa and 10 kPa were investigated. The results of membrane fouling mechanisms predicted by Hermia's model surmised that membrane fouling is principally caused by the cake layer model, and the application of the Unified Membrane Fouling Index for quantitative evaluation of antifouling properties substantiating membranes in sub-critical condition exhibited superior antifouling properties. The reversible membrane fouling was largely dependent on polysaccharides due to size exclusion. Proteins tended to block the membrane pores and to cause irreversible fouling. It was also observed that high-molecular weight (>100 kDa) extracellular organic matters contributed a significant portion of membrane fouling. For greater insight, the CRiteria Importance Through Intercriteria Correlation (CRITIC) method was administered; it could be concluded that the removal of proteins was more responsible for the total fouling resistance than was the removal of polysaccharides, especially for membranes at the TMP of 9 kPa.

Developing a flexible and adaptable sensor for the detection of ethanol vapor is important for many healthcare and environmental applications. Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate has shown excellent electrical properties and is easily processed. Adhesive tapes are used widely in many applications due to their excellent adaptability to various environments. Here, we show, for the first time, the development of a flexible adhesive tape-based sensor for the detection of ethanol vapor. The sensor shows a detection range of 5%–60% of saturated ethanol vapor and a rapid measuring time of about 15 s with an excellent linear correlation to the commercial available sensor. It is expected that these results could open exciting opportunities for fundamental studies of construction of new types of flexible sensors as well as serve in various healthcare, environmental, and defense applications.

Post-hydrothermal liquefaction wastewater (PHWW), which contains approximately 80% of original feedstock resources, shows great potential to achieve sustainable development of an environment-enhancing energy system. A combination of anaerobic digestion and algae cultivation was proposed for methane recovery and nutrient supply from PHWW. Granular activated carbon (GAC) and ozone were used to enhance energy recovery from the PHWW. The results indicated that with GAC addition, the maximum methane yield increased by 67.7%–228 mL/g CODremoval. In addition, Chlorella vulgaris displayed optimal growth in a 5-fold diluted digestate with a 2.32 g/L maximum biomass content and 180 mg/(L·d) biomass production rate. The total energy yield was 565 kJ/g COD, which was 27.4 times higher than that without GAC. Integration of anaerobic digestion and algae cultivation, particularly with GAC addition during fermentation, is a feasible and advantageous process for energy recovery from PHWW.

When a membrane is used to harvest algae, membrane fouling caused by algae and extracellular organic matter (EOM) is a serious challenge. A uniform shearing vibration membrane (USVM) system was devised and applied to reducing membrane fouling in algae filtration. The shear rate produced by USVM is constant because of its uniform circular motion; thus, USVM could stably and significantly mitigate fouling. During the filtration experiments where the frequency was increased from 1 to 5 Hz, the transmembrane pressure (TMP) visibly reduced. Even at a relatively low frequency of 5 Hz, USVM still could stably filter algae and had only slight membrane fouling. Increasing the vibration frequency not only could significantly reduce reversible membrane fouling but could also reduce irreversible membrane fouling. Protein could cause more serious reversible membrane fouling, while humic substances could lead to more serious irreversible membrane fouling. In this study, USVM effectively reduced the deposition of algae cells, protein, polysaccharide and humic substances on the membrane as frequency increased.

Nanoscale zerovalent iron (nZVI) has been proposed to remediate heavy metal ions in the subsurface. However, the fate of metal-nZVI hybrid has not been fully investigated. In this study, we investigated (1) the long-term removal performance of nZVI for molybdate (Mo(VI)); (2) the relationship between the ageing of Mo-nZVI hybrid in specific solution chemistries and the remobilization of Mo(VI) from the hybrid; and (3) the effects of Mo-nZVI hybrid on cyanobacteria (Microcystis aeruginosa). Results showed that although common ions have limited influence on the removal ratio of Mo(VI) by nZVI, they do impact the structure evolution and transformation of the Mo-nZVI nanohybrid formed thereafter. Ageing time was crucial for the chemical stabilization of Mo-nZVI hybrid, but common groundwater ions retarded the stabilizing process, which may lead to a significant remobilization of Mo(VI) from the hybrid after exposure to water bodies. While low levels of Mo(VI) ions could stimulate the growth of M. aeruginosa, aged Mo-nZVI hybrid inhibited the growth of M. aeruginosa, except when ageing occurred in the presence of HPO42−/CO32− (which also retarded hybrid stabilization). This study shows that nZVI can immobilize Mo(VI) ions in groundwater, and the derived metal-nZVI hybrid can effectively suppress the potential growth of M. aeruginosa in river water.

A closed process for microalgal biofuel production involving in lipid extraction, anaerobic digestion, and microalgal cultivation was proposed. Nutrients recycling and energy in the system were evaluated. During the anaerobic digestion process, 69.37% of nitrogen and 60.22% of phosphorus resided in the lipid-extracted microalgae (LEM) were released into the digested liquid (DL). Microalgae (Chlorella pyrenoidosa) could grow normally in mixed 10% DL and Selenite Enrichment (SE) medium (without nitrogen and phosphorus additives). The maximum biomass concentration was 1.25 g/L (dry biomass), which was higher than that obtained with the standard SE medium (1.18 g/L dry biomass). This indicates that the abundant nutrients in the DL can be recycled for more sustainable microalgae growth. Economic analysis evaluated that recycling of nutrients in the DL could potentially reduce nutrient cost by 41.77%. Additionally, 28.38% more energy was recovered as methane in LEM during the anaerobic digestion process. This would compensate for the cost of microalgae biofuel production.

Toxic heavy metals As(V) and Cr(VI) removal from water environment has becoming more and more urgent due to their adverse health effect. In this study, the flowerlike Ce/Fe bimetallic oxides (CFBO), which combined the superiority of three-dimensionally (3D) hierarchical architectures and bimetallic synergistic effect, were innovatively designed and synthesized via one-step facile template-free hydrothermal method. Compared with pure iron oxides (PIO), the obtained CFBO exhibited excellent performance for As(V) and Cr(VI) removal, and the maximum adsorption capacities toward As(V) and Cr(VI) increased from 49.09 mg/g to 164.94 mg/g and 38.07 mg/g to 127.42 mg/g, respectively. Both As(V) and Cr(VI) removal efficiency decreased with an increasing solution pH due to the pHzpc of CFBO, but exhibited slightly change with coexisting anions except for SiO32− and PO43− ions. Combined results of FT-IR and XPS, it was concluded that the abundant hydroxyl groups existed on the surface of CFBO played a key role in the high uptake of As(V) and Cr(VI), and subsequently formed inner-sphere surface complexes. Attractively, the remarkable removal efficiency of As(V)/Cr(VI) in column experiments revealed that the CFBO had great potential for practical application.

Although most patients with stage I non-small cell lung cancer (NSCLC) can achieve long-term survival, some still remain at high risk of relapse (1-3). The excellent outcomes and increasing use of stereotactic ablative radiotherapy (SABR) for stage I NSCLC has recently posed a challenge to surgery (4,5). Nevertheless, lobectomy with mediastinal lymph node dissection or sampling has remained the standard of care for operable, stage I NSCLC. Adjuvant chemotherapy should be considered for patients with stage IB (>4 cm) and high-risk NSCLC after surgery (6). Moreover, as a recent randomized phase III trial showed, adjuvant EGFR tyrosine kinase inhibitor (TKI) can significantly prolong disease-free survival (DFS) compared with adjuvant vinorelbine plus cisplatin in patients with completely resected stage II–IIIA (N1–N2) EGFR-mutant NSCLC (7). However, whether adjuvant EGFR-TKI could benefit patients with stage I EGFR-mutant NSCLC remains unknown (8,9). In addition, oligometastasis is a common relapse patterns after complete resection (10), and the delivery of radiation therapy is increasingly being delivered in these patients to prolong their progression-free survival (PFS) (11). A question that still remains is the impact of local therapy in combination with targeted therapy for patients with oligometastatic disease. Here, we presented a case of a patient with EGFR-mutant stage IA lung adenocarcinoma clinically benefitting from adjuvant EGFR-TKI. After that, the patient had bone oligometastasis and benefited from the addition of local therapy. During the treatment process, the international multidisciplinary team (iMDT) discussion played a pivotal role in the selection and switch of therapeutic strategies.

The widespread occurrence of penicillin antibiotics (PENs) in natural environment has raised increasing concerns due to their potential to induce antibiotic-genes. In this study, the degradation of PENs by UV/peroxodisulfate (PDS) process was investigated to determine the reaction kinetics, transformation mechanism and energy efficiency. The second-order rate constants for sulfate radical (SO4− ) and hydroxyl radical (HO ) with PENs, including, pencillin G (PG), amoxicillin (AMX) and carbenicillin (CBN), were determined to be (3.90–9.32) × 109 M−1·s−1 and (6.67–9.86) × 109 M−1·s−1, respectively. A pseudo steady-state kinetic model was employed and successfully predicted the degradation of PENs in ultrapure water. The modeling results revealed that both direct and indirect photolysis contributed to PENs degradation, and the contribution of indirect photolysis increased with the increase of PDS dosage. SO4− was the major contributor to PENs indirect photolysis. The effect of pH and water matrices, including HCO3−, Cl− and natural organic matter were evaluated and modeled. Combined with the modeling results, the derived radicals and excited species were likely generated and involved in the overall degradation of PENs. Based on the developed model, we gave a roughly calculation of electrical energy per order (EE/O) to evaluate the energy efficiency of PDS treatment processes. Finally, the transformation product analysis indicated that the thioether sulfur on the five-membered ring and the side chain, e.g., benzene ring on PG and CBN were the reactive sites for SO4− , while the primary amine was another reactive site for SO4− on AMX.

Sulfidation of nanoscale zerovalent iron (nZVI) has shown some fundamental improvements on reactivity and selectivity toward pollutants in dissolved-oxygen (DO)-stimulated Fenton-like reaction systems (DO/S-nZVI system). However, the pristine microstructure of sulfide-modified nanoscale zerovalent iron (S-nZVI) remains uncovered. In addition, the relationship between pollutant removal and the oxidation of the S-nZVI is largely unknown. The present study confirms that sulfidation not only imparts sulfide and sulfate groups onto the surface of the nanoparticle (both on the oxide shell and on flake-like structures) but also introduces sulfur into the Fe(0) core region. Sulfidation greatly inhibits the four-electron transfer pathway between Fe(0) and oxygen but facilitates the electron transfer from Fe(0) to surface-bound Fe(III) and consecutive single-electron transfer for the generation of H2O2 and hydroxyl radical. In the DO/S-nZVI system, slight sulfidation (S/Fe molar ratio = 0.1) is able to nearly doubl...

Allylic sulfones were synthesized with excellent selectivity and good yield via Pd-catalyzed cross-coupling of vinyl iodide with N-tosylhydrazone. This process involves palladium carbene migratory insertion/trapping with sulfinic acid salts. For the previous Pd-catalyzed N-tosylhydrazone cross-coupling, sulfinic acid salt is generated as a byproduct. In this transformation, the diazo compound and the sulfinic acid salt, which are all generated from N-tosylhydrazone, were used as cross-coupling partner.

We found that Pt-modified Ir-ReO x /SiO 2 acted as an effective catalyst for aqueous phase reforming (APR) and selective C-O hydrogenolysis of glycerol without external hydrogen sources at low temperature of 463 K, and that 0.5 wt% loaded Ir-ReO x /SiO 2 (Pt(0.5)-Ir-ReO x /SiO 2 ) provided 1,2-propanediol (1,2-PrD) and acetol in high total yield of 53% at 81% conversion. The initial activity (TOF initial ) over Pt(0.5)-Ir-ReO x /SiO 2 at 463 K was estimated to be 13 h −1 . Pt-Ir alloy and Ir-ReO x species in Pt-Ir-ReO x /SiO 2 are main active species for APR and selective C-O hydrogenolysis, respectively, and the high yield can be achieved by balancing the APR and hydrogenolysis activities through the optimization of Pt and Ir-ReO x molar ratio.

Microalgae play an important role in carbon sequestration by converting solar energy into biomass as an energy reserve. The conversion efficiency is often limited by light absorbed in the chloroplast. It is of great potential to enhance the photosynthesis capability by improving susceptibility of the light absorption by microalgae. Carbon-based quantum dots (QDs) are promising candidates for spectrum conversion, exhibiting remarkable biocompatibility, excellent water solubility, and customizable flexibility. Herein, we introduced graphene oxide quantum dots (GOQDs) with a blue light (465 nm) emission after ultraviolet (380 nm) excitation into the microalgae growth media. It is demonstrated that the ultraviolet light was effectively absorbed and utilized by the chlorophyll in the GOQDs-Chlorella pyrenoidosa system, resulting in a significantly increased photosynthetic activity. Moreover, a 20% improvement in carbon dioxide fixation and a 34% increase in bioenergy accumulation was found in the system. We further examined the microalgae metabolic pathways to reveal the biological response mechanism with GOQDs. Results verified that the GOQDs facilitated photosystem II (PSII) energy transfer to improve the photosynthesis of microalgae and upregulated the metabolites of lipid biosynthesis, resulting in a higher biomass and lipid content. This work suggested that using GOQDs as a promising approach for to improve the photosynthetic efficiency of microalgae, as well as a great potential for enhancing carbon capture and bioenergy production, especially in the environments with higher solar ultraviolet irradiation.

Liquid crystal (LC) lens has the characteristic of variable focal length. Many studies have demonstrated that electronically controlled focusing without mechanical movements can be realized by using LC lenses in imaging system. In this paper, a four-electrodes LC lens with a rectangular aperture is applied to focus. The aperture’s aspect ratio of the LC lens can be designed arbitrarily so that installing it with the periscope lens in phones becomes possible.

Emerging evidence has revealed the critical role of the tumor microenvironment (TME) in tumor progression, angiogenesis, metastasis, and immunosuppression. Oncolytic viruses (OVs), a versatile therapeutic agent that targets both cancer cells and the TME, have emerged as a promising candidate for antitumor therapy. Strategies of manipulating OVs against the TME include normalization of the tumor vasculature, decomposition of the tumor stroma, and reversion of the immunosuppressive microenvironment. In pancreatic cancer, desmoplastic stroma comprises up to 80% of the tumor mass, accompanied by hypovascularity and profound immunosuppression, conferring a particularly important role to TME-targeted oncolytic virotherapy. Mechanisms and supporting evidence of OVs reversing the tumor-privileged TME and applications of TME-targeted OVs for pancreatic cancer are summarized in this review.

The occurrence of tetracycline (TTC) in the environment can exacerbate microbial selection pressure and trigger bacterial resistance, raising potential risks to the ecosystem and public health. Here, we report that copper supported polyurethane foam (Cu-NC) can efficiently activate PMS to degrade TTC. Results demonstrated that the degradation rate of TTC was 91.3% and the pseudo first-order kinetic constant of 0.0762 min−1 was achieved after 40 min reaction at pH 5.0. Activation of PMS by Cu-NC was proposed to proceed via two sequential processes, which was different from the conventional mechanism for sulfate radical generation. Cu0 initially reacts with dissolved oxygen to generate H2O2 and Cu(I)(s) in situ in the solid form. Then Cu(I)(s) solves the relative instability of low-valent transition metal ions in aqueous solution, thus improving the activation efficiency of PMS. A novel mechanism for Cu(I)(s) activation of PMS to generate HO• was proposed and elucidated through outer-sphere interaction (electrostatic bonding) and acid-base theory. Superoxide radical and Cu0 accelerate the Cu(II)/Cu(I) redox, overcoming the rate-limiting step in Fenton-like reaction. Cu-NC showed an excellent cycling stability (80.8% removal efficiency after fifth run) in PMS activation with low Cu ion leaching (＜0.2 mg/L). The Cu-NC/PMS system also exhibited satisfactory removal of TTC in the presence of various water matrices. This study can deepen the understanding of the generation of HO• in the PMS activation process and provide a promising strategy for pollutants degradation in wastewater treatment.

A novel Co@MXenes catalyst with unique structure was prepared through randomly anchoring cobalt on 2D sandwich-like MXenes to activate peracetic acid (PAA) for water decontamination. Compared to the conventional Co3O4 nanomaterial, the Co@MXenes catalyst exhibits superior performance for PAA activation under neutral condition. In-depth investigation revealed that the Ti3C2Tx MXene substrate triggered the ≡ Co(III)/≡ Co(II) cycle, which greatly enhanced the activation of PAA. The XPS and ICP techniques further demonstrated that Co@MXenes was highly stable with extremely low cobalt ion leaching and hence a superior reusability was obtained. Moreover, acetylperoxyl radical (CH3CO3 ) was identified as the primary radical species responsible for organic micropollutants degradation, exhibiting high selectivity towards contaminants containing electron-rich groups. The novel technology exhibited a high tolerance of Cl− and good performance in real wastewater treatment. This work provides a promising effective catalyst for PAA activation and will facilitate PAA application in wastewater decontamination.

Any single existing technique cannot monitor the overall membrane fouling behavior in heterotrophic microalgae harvesting. Herein, multi-dimensional methods, included deposition dynamic, foulants spatial distribution, chemical composition and interactive force features, were developed to dissect the fouling mechanisms. Findings indicate that particles deposition rate was the largest in the initial stage due to the high permeate flux. Protein deposition rate had greatest influence on the permeate flux decline. Cake layer condense process was confirmed by the rigid particles. And the cake layer with low porosity at the bottom and orderly deposition presented good resistance performance on algae-related fouling. 3D evolution of the cake layer was a Brownian-tree liked formation process, namely, rivet seed-cluster-monolayer-multilayers. Interaction force analysis confirmed that the interfaces with protein and the loose cake layer always presented strong attractive forces. Permeate drag force and electrical repulsion force played important role on the algae cake formation in the initial stage and cake layer formation stage, respectively. Multi-dimensional techniques shed light on foulants occurrence and accumulation as well as the cake layer evolution in the membrane microalgae harvesting process.