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692 results on '"Yamamoto, Kouji"'

153. A measure of asymmetry for ordinal square contingency tables with an application to modified LANZA score data.

Author

Shinoda, Satoru, Yamamoto, Kouji, Tahata, Kouji, and Tomizawa, Sadao

Subjects
*CONTINGENCY tables, *TALLIES, *CATEGORIES (Mathematics)
Abstract

In clinical researches, various clinical scales with ordered categories are used to evaluate the efficacy and safety/toxicity of treatments. Such the clinical scales are sometimes summarized on the transition between the baseline and the study end point as a square contingency table. Also, clinical scales may be reclassified into three groups. However, the cutpoints can be varied depending on clinical researches or clinicians. Hence, this paper proposes a measure which is expressed by using same weights for collapsed tables and which can see the directionality for two kinds of asymmetries. Also, this paper shows an application of the proposed measure to clinical data, and that the proposed measure is a useful statistical method for analyzing ordered categorical data. [ABSTRACT FROM AUTHOR]

Published
2020
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154. Independent association of plasma xanthine oxidoreductase activity with serum uric acid level based on stable isotope-labeled xanthine and liquid chromatography/triple quadrupole mass spectrometry: MedCity21 health examination registry.

Author

Kurajoh, Masafumi, Fukumoto, Shinya, Emoto, Masanori, Murase, Takayo, Nakamura, Takashi, Ishihara, Takuma, Go, Hirofumi, Yamamoto, Kouji, Nakatani, Shinya, Tsuda, Akihiro, Yamada, Shinsuke, Morioka, Tomoaki, Mori, Katsuhito, Imanishi, Yasuo, and Inaba, Masaaki

Subjects
URIC acid, PERIODIC health examinations, XANTHINE, MASS spectrometry, SYSTOLIC blood pressure, GLYCOSYLATED hemoglobin
Abstract

Background: We developed a novel high-sensitive assay for plasma xanthine oxidoreductase (XOR) activity that is not affected by the original serum uric acid level. However, the association of plasma XOR activity with that level has not been fully examined. Methods: This cross-sectional study included 191 subjects (91 males, 100 females) registered in the MedCity21 health examination registry. Plasma XOR activity was determined using our assay for plasma XOR activity with [13C2,15N2] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Serum levels of uric acid and adiponectin, and visceral fat area (VFA) obtained by computed tomography were measured, and insulin resistance was determined based on the homeostasis model assessment (HOMA-IR) index. Results: The median values for uric acid and plasma XOR activity were 333 μmol/L and 26.1 pmol/h/mL, respectively. Multivariable linear regression analysis showed a significant and positive association of serum uric acid level (coefficient: 26.503; 95% confidence interval: 2.06, 50.945; p = 0.035) with plasma XOR activity independent of VFA and HOMA-IR, and also age, gender, alcohol drinking habit, systolic blood pressure, estimated glomerular filtration rate (eGFR), glycated hemoglobin A1c, triglyceride, and adiponectin levels. The "gender*XOR activity" interaction was not significant (p = 0.91), providing no evidence that gender modifies the relationship between plasma XOR activity and serum uric acid level. Conclusions: Plasma XOR activity was found to be positively associated with serum uric acid level independent of other known confounding factors affecting that level, including gender difference, eGFR, adiponectin level, VFA, and HOMA-IR. [ABSTRACT FROM AUTHOR]

Published
2020
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155. An exact test for comparing two predictive values in small‐size clinical trials.

Author

Takahashi, Kanae and Yamamoto, Kouji

Subjects
*FALSE positive error, *CLINICAL trials, *ERROR rates, *CONFORMANCE testing, *TEST methods
Abstract

Positive and negative predictive values describe the performance of a diagnostic test. There are several methods to test the equality of predictive values in paired designs. However, these methods were premised on large sample theory, and they may not be suitable for small‐size clinical trials because of inflation of the type 1 error rate. In this study, we propose an exact test to control the type 1 error rate strictly for conducting a small‐size clinical trial that investigates the equality of predictive values in paired designs. In addition, we execute simulation studies to evaluate the performance of the proposed exact test and existing methods in small‐size clinical trials. The proposed test can calculate the exact P value, and as a result of simulations, the empirical type 1 error rate for the proposed test did not exceed the significance level regardless of the setting, and the empirical power for the proposed test is not much different from the other methods based on large‐sample theory. Therefore, it is considered that the proposed exact test is useful when the type 1 error rate needs to be controlled strictly. [ABSTRACT FROM AUTHOR]

Published
2020
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157. Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells

Author

Tamori, Shoma, primary, Nozaki, Yuka, additional, Motomura, Hitomi, additional, Nakane, Hiromi, additional, Katayama, Reika, additional, Onaga, Chotaro, additional, Kikuchi, Eriko, additional, Shimada, Nami, additional, Suzuki, Yuhei, additional, Noike, Mei, additional, Hara, Yasushi, additional, Sato, Keiko, additional, Sato, Tsugumichi, additional, Yamamoto, Kouji, additional, Hanawa, Takehisa, additional, Imai, Misa, additional, Abe, Ryo, additional, Yoshimori, Atsushi, additional, Takasawa, Ryoko, additional, Tanuma, Sei-Ichi, additional, and Akimoto, Kazunori, additional

Published
2018
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165. Measure of departure from marginal point-symmetry for two-way contingency tables

Author

YAMAMOTO, KOUJI, Center Of Clinical Investigation And Research-Osaka University Hospital, TAHATA, KOUJI, Department Of Information Sciences, Faculty Of Science And Technology-Tokyo University Of Science, SUZUKI, MOTOKO, and TOMIZAWA, SADAO

Subjects
lcsh:Statistics, lcsh:HA1-4737
Abstract

For two-way contingency tables, Tomizawa (1985) considered the point-symmetry and marginal point-symmetry models, and Tomizawa, Yamamoto and Tahata (2007) proposed a measure to represent the degree of departure from point-symmetry. The present paper proposes a measure to represent the degree of departure from marginal pointsymmetry for two-way tables. The proposed measure is expressed by using Cressie-Read power-divergence or Patil-Taillie diversity index. This measure would be useful for comparing the degrees of departure from marginal point-symmetry in several tables. The relationship between the degree of departure from marginal point-symmetry and the measure is shown when it is reasonable to assume underlying bivariate normal distribution. Examples are shown., Statistica; Vol 71, No 3 (2011); 367-380

Published
2013

170. Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection

Author

Nagami, Yasuaki, primary, Ominami, Masaki, additional, Shiba, Masatsugu, additional, Sakai, Taishi, additional, Fukunaga, Shusei, additional, Sugimori, Satoshi, additional, Otani, Koji, additional, Hosomi, Shuhei, additional, Tanaka, Fumio, additional, Taira, Koichi, additional, Kamata, Noriko, additional, Yamagami, Hirokazu, additional, Tanigawa, Tetsuya, additional, Watanabe, Toshio, additional, Ishihara, Takuma, additional, Yamamoto, Kouji, additional, and Fujiwara, Yasuhiro, additional

Published
2017
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171. Impact of a Food Safety Campaign on Streptococcus suis Infection in Humans in Thailand

Author

Takeuchi, Dan, primary, Loetthong, Phacharaphan, additional, Anukul, Rapeepun, additional, Tanburawong, Nutchada, additional, Samerchea, Sutit, additional, Areeratana, Prasanee, additional, Lekhalula, Punpong, additional, Puangmali, Panarat, additional, Nakayama, Tatsuya, additional, Yamamoto, Kouji, additional, Khamisara, Kasean, additional, Hirose, Masayo, additional, Hamada, Shigeyuki, additional, Kerdsin, Anusak, additional, Dejsirilert, Surang, additional, Akeda, Yukihiro, additional, Oishi, Kazunori, additional, Chiranairadul, Piphat, additional, and Pinyo, Wirasinee, additional

Published
2017
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173. Mitral Valve Structure in Addition to Myocardial Viability Determines the Outcome of Functional Mitral Regurgitation After Coronary Artery Bypass Grafting

Author

Yoshida, Shohei, primary, Fukushima, Satsuki, additional, Miyagawa, Shigeru, additional, Nakamura, Teruya, additional, Yoshikawa, Yasushi, additional, Hata, Hiroki, additional, Saito, Shunsuke, additional, Yoshioka, Daisuke, additional, Domae, Keitaro, additional, Kashiyama, Noriyuki, additional, Yamamoto, Kouji, additional, Shintani, Ayumi, additional, Nakatani, Satoshi, additional, Toda, Koichi, additional, and Sawa, Yoshiki, additional

Published
2017
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178. Panoramic Measurement and Analysis of Strain Distribution in the Human ACL Using a Photoelastic Coating Method

Author

Kawada Takashi, Yamamoto Kouji, and Hirokawa Shunji

Subjects
Engineering drawing, Materials science, Mechanical Engineering, musculoskeletal system, Industrial and Manufacturing Engineering, surgical procedures, operative, Tilt (optics), All fiber, Mechanics of Materials, Strain distribution, Femoral bone, Photoelastic coating, human activities, Biomedical engineering
Abstract

Large and highly variable deformations of the ACL cannot be adequately quantified by one-dimensional and/or localized measurements. Since the complex anatomy of the ACL makes uniform loading of all fiber bundles almost impossible, strains on specific portions being tested are considerably altered during knee movement. To observe the ACL's entire surface, we propose a photoelastic coating method. A simulator jig was used to allow a natural motion of the knee whose medial and lateral femoral bone parts were removed in order to expose the ACL for observation. The simulator jig with the knee was mounted on a universal stand which allows tilt and swivel rotations, so that the exposed ACL might be viewed from any direction. Measurements were performed on the strain distributions over the ACL at various knee angles. The panoramic images of the photoelastic fringe patterns yielded significant results.

Published
2001
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186. Study on the Mechanism of Improvement of Realistic Sensation on Driving Simulator Based on Measurement of Cortical Brain Activity for Sign and Information Boards

Author

JEONG, Yonghyun, primary, SUGIMACHI, Toshiyuki, additional, NAKANO, Kimihiko, additional, TABUCHI, Yoshihiko, additional, SUDA, Yoshihiro, additional, ORINO, Yoshitomo, additional, YAMAMOTO, Kouji, additional, KAMEOKA, Hiroyuki, additional, TAKAHASHI, Hideki, additional, OKA, Noriyuki, additional, YOSHINO, Kayoko, additional, and KATO, Toshinori, additional

Published
2016
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189. THYROID DYSFUNCTION FOLLOWING ALPHA-INTERFERON TREATMENT FOR CHRONIC HEPATITIS C

Author

Ueda, Shigehiko, Yoshikawa, Masahide, Okamoto, Shingo, Tamagawa, Taiko, Tsujinoue, Hirohisa, Ishii, Yoshinobu, Tsuruzono, Takuya, Kawamoto, Hiroshi, Kawata, Mitsuhiro, Yamazaki, Masaharu, Yamamoto, Hiroshi, Moriyasu, Hiroto, Miyamoto, Youji, Kimura, Takaaki, Masui, Kazuhiro, Yamamoto, Kouji, Mitoro, Akira, Mimura, Mayumi, Kyo, Masanaga, Sakamoto, Takemi, Takagi, Masahiro, Fukui, Hiroshi, and Tsujii, Tadasu

Subjects
endocrine system, endocrine system diseases, thyroid function autoimmune disease, chronic hepatitis C, interferon therapy
Abstract

In order to evaluate the influnces of IFNα on thyroid function, thyroid-stimulating hormone (TSH), total thyroxine (T4), free T4, tri-iodothyronine (T3), and thyroxine-binding globulin were examined in IFNα-treated 351 patients with chronic hepatitis C before and during therapy. As therapy, either 3 million units (MU) of human lymphoblastoid IFNα or 9MU of recombinant IFNα2a was administrated daily for the initial two weeks followed by three times a week for 22 weeks. There were nine patients showing thyroid dysfunction during IFNα therapy. They consist of one relapse of Graves' disease, one relapse of Hashimoto thyroiditis, one development of apparent thyroid insufficiency from subclinical hypothyroidism, five cases with transient hyperthyroidism and one case with transient hypothyroidism. T4 and T3 levels in most patients who transiently developed thyroid dysfunction were normalized spontaneously after the discontinuation of IFNα. Thyroid-related autoantibodies were positive in 4 patients before IFNα therapy and newly developed in one patient during therapy. Attention should be paid first to the previous histories of autoimmune thyroid diseases and the existence of thyroid-related autoantibodies for the prediction of development of thyroid dysfunction during IFNα therapy. In addition, serial examinations of TSH, T3 and T4 should be also necessary for early detection of transient thyroid dysfunction during IFNα therapy.

Published
1994

190. Measure of Departure from Average Marginal Homogeneity for Square Contingency Tables with Ordered Categories

Author

Yamamoto, Kouji, Ando, Shuji, and Tomizawa, Sadao

Abstract

For the analysis of square contingency tables, Tomizawa, Miyamoto and Ashihara (2003) considered a measure to represent the degree of departure from marginal homogeneity. However, the maximum value of this measure cannot distinguish two kinds of marginal inhomogeneity. This paper proposes a measure which can distinguish two kinds of marginal inhomogeneity for square tables with ordered categories. The measure is constructed using the arc-cosine function of symmetric cumulative probabilities. Especially the proposed measure is useful for representing the degree of departure from marginal homogeneity when the extended marginal homogeneity model holds. Examples are given., REVSTAT-Statistical Journal, Vol. 9 No. 2 (2011): REVSTAT-Statistical Journal

Published
2011
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196. Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

Author

Hirose, Tomoya, Hamaguchi, Shigeto, Matsumoto, Naoya, Irisawa, Taro, Seki, Masafumi, Tasaki, Osamu, Hosotsubo, Hideo, Yamamoto, Norihisa, Yamamoto, Kouji, Akeda, Yukihiro, Oishi, Kazunori, Tomono, Kazunori, Shimazu, Takeshi, Hirose, Tomoya, Hamaguchi, Shigeto, Matsumoto, Naoya, Irisawa, Taro, Seki, Masafumi, Tasaki, Osamu, Hosotsubo, Hideo, Yamamoto, Norihisa, Yamamoto, Kouji, Akeda, Yukihiro, Oishi, Kazunori, Tomono, Kazunori, and Shimazu, Takeshi

Abstract

Neutrophil extracellular traps (NETs), a newly identified immune mechanism, are induced by inflammatory stimuli. Modification by citrullination of histone H3 is thought to be involved in the in vitro formation of NETs. The purposes of this study were to evaluate whether NETs and citrullinated histone H3 (Cit-H3) are present in the bloodstream of critically ill patients and to identify correlations with clinical and biological parameters. Blood samples were collected from intubated patients at the time of ICU admission from April to June 2011. To identify NETs, DNA and histone H3 were visualized simultaneously by immunofluorescence in blood smears. Cit-H3 was detected using a specific antibody. We assessed relationships of the presence of NETs and Cit-H3 with the existence of bacteria in tracheal aspirate, SIRS, diagnosis, WBC count, and concentrations of IL-8, TNF-a, cf-DNA, lactate, and HMGB1. Forty-nine patients were included. The median of age was 66.0 (IQR: 52.5-76.0) years. The diagnoses included trauma (7, 14.3%), infection (14, 28.6%), resuscitation from cardiopulmonary arrest (8, 16.3%), acute poisoning (4, 8.1%), heart disease (4, 8.1%), brain stroke (8, 16.3%), heat stroke (2, 4.1%), and others (2, 4.1%). We identified NETs in 5 patients and Cit-H3 in 11 patients. NETs and/or Cit-H3 were observed more frequently in "the presence of bacteria in tracheal aspirate" group (11/22, 50.0%) than in "the absence of bacteria in tracheal aspirate" group (4/27, 14.8%) (p<.01). Multiple logistic regression analysis showed that only the presence of bacteria in tracheal aspirate was significantly associated with the presence of NETs and/or Cit-H3. The presence of bacteria in tracheal aspirate may be one important factor associated with NET formation. NETs may play a pivotal role in the biological defense against the dissemination of pathogens from the respiratory tract to the bloodstream in potentially infected patients., PLoS ONE, 9(11), e111755; 2014

Published
2014

197. Analyses of tumor microenvironment affecting the survival in patients with ovarian cancer receiving intraperitoneal chemotherapy: Translational research from the phase 3 trial of intraperitoneal therapy for ovarian cancer with carboplatin (TRiPocc).

Author

Ogasawara, Aiko, Matsushita, Hirokazu, Tan, Tuan Zea, Shintani, Daisuke, Ye, Jieru, Nagao, Shoji, Kobayashi, Yukari, Kakimi, Kazuhiro, Yamaguchi, Rui, Yamamoto, Kouji, Fujiwara, Keiichi, Huang, Ruby Yun-Ju, Tan, David Shao Peng, and Hasegawa, Kosei

Published
2023
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198. Primary analysis of a phase II study of atezolizumab plus bevacizumab for TACE-unsuitable patients with tumor burden beyond up-to-seven criteria in intermediate-stage hepatocellular carcinoma: REPLACEMENT study.

Author

Ueshima, Kazuomi, Kudo, Masatoshi, Tsuchiya, Kaoru, Kato, Naoya, Yamashita, Tatsuya, Shimose, Shigeo, Numata, Kazushi, Kodama, Yuzo, Tanaka, Yasuhito, Kuroda, Hidekatsu, Itoh, Shinji, Aikata, Hiroshi, Hiraoka, Atsushi, Moriguchi, Michihisa, Wada, Yoshiyuki, Nakao, Kazuhiko, Tateishi, Ryosuke, Ogasawara, Sadahisa, Yamamoto, Kouji, and Ikeda, Masafumi

Published
2023
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199. Subgroup analysis of double-blind, placebo-controlled Ph. 2 study of nanvuranlat in treatment of pre-treated, advanced, refractory biliary tract cancer (BTC): Patients with high LAT1 expression and response to nanvuranlat.

Author

Ikeda, Masafumi, Ueno, Makoto, Furukawa, Masayuki, Morizane, Chigusa, Takehara, Tetsuo, Nishina, Tomohiro, Todaka, Akiko, Okano, Naohiro, Hara, Kazuo, Nakai, Yousuke, Ohkawa, Kazuyoshi, Sasaki, Takashi, Sugimori, Kazuya, Yokoyama, Naoyuki, Yamamoto, Kouji, and Furuse, Junji

Published
2023
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200. Efficacy of panitumumab in patients with left-sided disease, MSS/MSI-L, and RAS / BRAF WT: A biomarker study of the phase III PARADIGM trial.

Author

Yamazaki, Kentaro, Muro, Kei, Watanabe, Jun, Shitara, Kohei, Ohori, Hisatsugu, Shiozawa, Manabu, Yasui, Hirofumi, Oki, Eiji, Sato, Takeo, Naito, Takeshi, Komatsu, Yoshito, Kato, Takeshi, Soeda, Junpei, Yamamoto, Kouji, Yamashita, Riu, Akagi, Kiwamu, Ochiai, Atsushi, Uetake, Hiroyuki, Tsuchihara, Katsuya, and Yoshino, Takayuki

Published
2023
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