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1,416 results on '"Yan, Xuefeng"'

157. Ros-responsive dextran-phenylboronic acid-silibinin nanoparticles for targeting delivery of BAPTA-AM to effectively eliminate calcium overload-mediated inflammatory cascades and mitochondrial apoptosis: Alleviating acute liver injury

Author

Wang, Yanan, primary, Wei, Huichao, additional, Li, Keyang, additional, Liu, Liru, additional, Zhu, Yingfei, additional, Wang, Xinyuan, additional, Yan, Jiahui, additional, Yu, Liangmin, additional, Yan, Xuefeng, additional, and He, Zhiyu, additional

Published
2023
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160. Analysis of Sound Absorbing Properties of Activated Carbon Fiber Felts Based on Density Change

Author

SHEN Yue, YAN Xuefeng, and LIU Qixia

Subjects
activated carbon fiber, felts, sound absorption coefficient, characteristic impedance, propagation constant, structural constant, Technology
Abstract

In order to study the sound absorbing properties of activated carbon fiber felts, three kinds of activated carbon fiber felts with different densities were selected, and the double channel acoustic analyzer with impedance tube was used to test the surface acoustic impedance within 125-2 500 Hz frequency sound waves. Then the four acoustic parameters, that is the sound absorption coefficient, the characteristic impedance, the propagation constant, and the structural constant, were calculated. Finally, the effect of density on the sound absorbing properties of activated carbon fiber felts was analyzed. It was found that with the increase of the frequency, the sound absorption coefficient and the propagation constant of the sample increased, but the characteristic impedance ratio and the structural constant decreased, but the decline was smaller and tended to be stable. With the increase of the density of activated carbon fiber felts, the acoustic parameters of the samples all increased, but the first resonance frequency moved towards low frequency, and the corresponding sound absorption coefficient increased.

Published
2021
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163. Hidden Markov Model for Floating Car Trajectory Map Matching

Author

Song, Chengbo, Yan, Xuefeng, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Park, James J., editor, Loia, Vincenzo, editor, Yi, Gangman, editor, and Sung, Yunsick, editor

Published
2018
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177. Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca2+Homeostasis Regulation and Pancreas Autodigestion Inhibition

Author

Wang, Yanan, Wang, Xinyuan, Zhang, Xue, Zhang, Baomei, Meng, Xinlei, Qian, Deyao, Xu, Yatao, Yu, Liangmin, Yan, Xuefeng, and He, Zhiyu

Abstract

Severe acute pancreatitis (AP) is a life-threatening pancreatic inflammatory disease with a high mortality rate (~40%). Existing pharmaceutical therapies in development or in clinical trials showed insufficient treatment efficacy due to their single molecular therapeutic target, poor water solubility, short half-life, limited pancreas-targeting specificity, etc. Herein, acid-responsive hollow mesoporous Prussian blue nanoparticles wrapped with neutrophil membranes and surface modified with the N,N-dimethyl-1,3-propanediamine moiety were developed for codelivering membrane-permeable calcium chelator BAPTA-AM (BA) and trypsin activity inhibitor gabexate mesylate (Ga). In the AP mouse model, the formulation exhibited efficient recruitment at the inflammatory endothelium, trans-endothelial migration, and precise acinar cell targeting, resulting in rapid pancreatic localization and higher accumulation. A single low dose of the formulation (BA: 200 µg kg–1, Ga: 0.75 mg kg–1) significantly reduced pancreas function indicators to close to normal levels at 24 h, effectively restored the cell redox status, reduced apoptotic cell proportion, and blocked the systemic inflammatory amplified cascade, resulting in a dramatic increase in the survival rate from 58.3 to even 100%. Mechanistically, the formulation inhibited endoplasmic reticulum stress (IRE1/XBP1 and ATF4/CHOP axis) and restored impaired autophagy (Beclin-1/p62/LC3 axis), thereby preserving dying acinar cells and restoring the cellular “health status”. This formulation provides an upstream therapeutic strategy with clinical translation prospects for AP management through synergistic ion homeostasis regulation and pancreatic autodigestion inhibition.

Published
2024
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