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The wire rope damage signal is a kind of non-stationary and non-periodic impact signal, and the noise reduction processing and characteristic extraction of its characteristic signal become difficult problems to be solved urgently. If the wavelet base or decomposition layer number of wavelet transform method is not suitable, which will introduce other noise interference while reducing signal noise, and affect the effect of signal processing and characteristic extraction. Compared with the wavelet transform, the moving average method only needs to select a certain shift window width to achieve effective noise reduction, but the shift window width needs to be selected artificially, and the blindness is large. In order to solve the above problems, a noise reduction method of wire rope damage signal under strong noise background is proposed. Different types of broken wire data are collected by magnetic flux leakage (MFL) sensor of wire rope, and strong Gaussian white noise is added to the signal to simulate the strong noise background. The adaptive moving average method is used to reduce the noise of the wire rope damage signal, and the quantum particle swarm optimization (QPSO) algorithm is used to optimize the window width of the moving average method. The signal-to-noise ratio (SNR) of the damage signal is used as the fitness function, and the SNR of damage characteristic signal is maximized by the QPSO algorithm, so as to achieve the optimal signal noise reduction effect. The experimental results show that compared with wavelet transform, the adaptive moving average method has more obvious noise reduction effect, higher signal-to-noise ratio and smoother signal for wire rope stationary and fluctuating signals under strong noise background. The measured results show that the noise reduction effect of the adaptive moving average method is also better than that of the wavelet transform for the wire rope damage signals with relatively weak noise on site, which verifies that the adaptive moving average method has good universality.

Flexible ammonia (NH3) gas sensors have gained increasing attention for their potential in medical diagnostics and health monitoring, as they serve as a biomarker for kidney disease. Utilizing the pre-designable and porous properties of covalent organic frameworks (COFs) is an innovative way to address the demand for high-performance NH3 sensing. However, COF particles frequently encounter aggregation, low conductivity, and mechanical rigidity, reducing the effectiveness of portable NH3 detection. To overcome these challenges, we propose a practical approach using polyvinyl alcohol-carrageenan (κPVA) as a template for in the situ growth of two-dimensional COF film and particles to produce a flexible hydrogel gas sensor (COF/κPVA). The synergistic effect of COF and κPVA enhances the gas sensing, water retention, and mechanical properties. The COF/κPVA hydrogel shows a 54.4% response to 1 ppm NH3 with a root mean square error of less than 5% and full recovery compared to the low response and no recovery of bare κPVA. Owing to the dual effects of the COF film and the particles anchoring the water molecules, the COF/κPVA hydrogel remained stable after 70 h in atmospheric conditions, in contrast, the bare κPVA hydrogel was completely dehydrated. Our work might pave the way for highly sensitive hydrogel gas sensors, which have intriguing applications in flexible electronic devices for gas sensing. [ABSTRACT FROM AUTHOR]

Numerous studies have suggested that intra‐articular administration of antibiotics following primary revision surgery may be one of the methods for treating prosthetic joint infection (PJI). Vancomycin and meropenem are the two most commonly used antibiotics for local application. Determining the concentrations of vancomycin and meropenem in the serum and synovial fluid of patients with PJI plays a significant role in further optimizing local medication schemes and effectively eradicating biofilm infections. This study aimed to establish a rapid, sensitive, and accurate ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for determining the concentrations of vancomycin and meropenem in human serum and synovial fluid. Serum samples were processed using acetonitrile precipitation of proteins and dichloromethane extraction, while synovial fluid samples were diluted before analysis. Chromatographic separation was achieved in 6 min on a Waters Acquity UPLC BEH C18 column, with the mobile phase consisting of 0.1% formic acid in water (solvent A) and acetonitrile (solvent B). Quantification was carried out using a Waters XEVO TQD triple quadrupole mass spectrometer with an electrospray ionization (ESI) source in positive ion mode. The multiple reaction monitoring (MRM) mode was employed to detect the following quantifier ion transitions: 717.95–99.97 (norvancomycin), 725.90–100.04 (vancomycin), 384.16–67.99 (meropenem). The method validation conformed to the guidelines of the FDA and the Chinese Pharmacopoeia. The method demonstrated good linearity within the range of 0.5–50 μg/ml for serum and 0.5–100 μg/ml for synovial fluid. Selectivity, intra‐day and inter‐day precision and accuracy, extraction recovery, matrix effect, and stability validation results all met the required standards. This method has been successfully applied in the pharmacokinetic/pharmacodynamic (PK/PD) studies of patients with PJI. [ABSTRACT FROM AUTHOR]

Purpose. This study aimed to investigate nurses' perceptions of spirituality and spiritual care and perceived professional benefits in China and reveal the relationship between them. Design and Methods. In this study, 372 nurses (response rate: 93.47%) from a number of hospitals across China were surveyed using convenience sampling. The data were collected through online questionnaires, including a sociodemographic characteristics form, the Chinese version of the Spiritual Care-Giving Scale (C-SCGS), and the Nurses' Perceived Professional Benefits Questionnaire (NPPBQ). Findings. The total score of the NPPBQ was 136.88±20.13. A statistically significant relationship was found between the total score and subscale score of the C-SCGS and the total score and subscale score of the NPPBQ (R=0.217-0.475, P, Author(s): Xiaoying Zeng [1]; Jianhua Yang [1]; Yanjia Li [1]; Min Chen [2]; Jue Wu [3]; Yanli Hu [4]; Weinan Lu [1]; Jing Liu [1]; Qian Yang [1]; Wenqiong Guo [...]