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Abstract Background This study aimed to investigate a gender-specific association between oral health-related quality of life (OHRQoL) and depressive symptoms in college students, as there are limited relevant studies conducted among youths. Methods In 2017, a cross-sectional study of 3461 Chinese college students was conducted in Shenyang, China. OHRQoL and depressive symptoms were screened by a 14-item oral health impact profile questionnaire and a Self-rating Depression Scale, respectively. A multivariable logistic regression analysis was performed to examine the association of OHRQoL with depressive symptoms. Results The number of youths reported to have depressive symptoms was 20.7%. A univariate analysis showed that categories with a OHRQoL score over 6 were more likely to have a higher prevalence of depressive symptoms compared to the category with a score of 0 (male: ORs [95% CI]: 3.10, 2.05–4.68, P

Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals that are widely used in industrial and consumer products. A growing body of literature suggests that exposure to these chemicals are associated with adverse reproductive outcomes in women. However, the sources of PFAS exposure are often poorly characterized in women of child-bearing age. Objectives: To examine the association of plasma PFAS concentrations with dietary intake and drinking water sources in reproductive aged women in Shanghai, one of the high PFAS polluted regions in China. Methods: Concentrations of ten PFAS in plasma samples were measured in 933 women. Information on dietary intake and type of drinking water was collected by questionnaire. We used multivariable linear regression models to assess the association of PFAS concentrations with dietary intake and drinking water. Results: After controlling for potential confounders, a higher frequency of intake of aquatic products (freshwater fish, marine fish, shellfish, shrimp and crab) was positively and significantly associated with concentrations of PFOS, PFOA, PFNA, PFDA, PFUA and PFDoA in 900 reproductive aged women. Intake of freshwater fish showed the strongest association with PFAS. Compared with the lowest intake group of freshwater fish, the intermediate intake group had 8–32% increase in the concentrations of these pollutants; and the highest group had 11–57% increase. Conversely, intake of soy products was associated with lower levels of PFDA, PFUA, PFNA, PFOS, and PFDoA. In addition, compared with women drinking tap water, drinking bottled water was associated with significantly decreases in PFHpA, PFDA, PFOA, PFUA and PFBS blood levels by 9–13% in 905 reproductive aged women. Conclusions: Intake of freshwater fish, marine fish, shrimp and crab was positively associated with plasma PFAS concentrations, while intake of soy products and bottled water was associated with lower PFAS concentrations in the Chinese women of reproductive age. Keywords: Perfluoroalkyl and polyfluoroalkyl substances (PFAS), Diet, Drinking water, China

Abstract. Background:. The comparative outcomes of subcutaneous implantable cardioverter-defibrillator (S-ICD) and transvenous ICD (T-ICD) have not been well studied. The aim of this study was to evaluate the safety and efficacy of currently available S-ICD and T-ICD. Methods:. The study included 86 patients who received an S-ICD and 1:1 matched to those who received single-chamber T-ICD by gender, age, diagnosis, left ventricular ejection fraction (LVEF), and implant year. The clinical outcomes and implant complications were compared between the two groups. Results:. The mean age of the 172 patients was 45 years, and 129 (75%) were male. The most common cardiac condition was hypertrophic cardiomyopathy (HCM, 37.8%). The mean LVEF was 50%. At a mean follow-up of 23 months, the appropriate and inappropriate ICD therapy rate were 1.2% vs. 4.7% (χ 2 = 1.854, P = 0.368) and 9.3% vs. 3.5% (χ 2 = 2.428, P = 0.211) in S-ICD and T-ICD groups respectively. There were no significant differences in device-related major and minor complications between the two groups (7.0% vs. 3.5%, χ 2 = 1.055, P = 0.496). The S-ICD group had higher T-wave oversensing than T-ICD group (9.3% vs. 0%, χ 2 = 8.390, P = 0.007). Sixty-five patients had HCM (32 in S-ICD and 33 in T-ICD). The incidence of major complications was not significantly different between the two groups. Conclusions:. The efficacy of an S-ICD is comparable to that of T-ICD, especially in a dominantly HCM patient population. The S-ICD is associated with fewer major complications demanding reoperation.

In our previous studies, we identified 3 Trichoderma strains with anti-Fusarium oxysporum activity, including T. asperellum 525, T. harzianum 610, and T. pseudokoningii 886. Here, we evaluated the effects of these 3 Trichoderma strains on preventing cucumber fusarium wilt through pot culture and greenhouse culture experiments. All 3 Trichoderma strains demonstrated higher control effects toward cucumber fusarium wilt than previous studies, with efficacies over 78%. Additionally, inoculation with the 3 Trichoderma strains significantly promoted the quality and yield of cucumbers. Among the 3 strains, Trichoderma 866 was the most effective, with disease control efficacy of 78.64% and a cucumber yield increase of 33%. Furthermore, seedlings inoculated with Trichoderma exhibited significantly increased measures of plant height, stem diameter, leaf area, aboveground fresh weight, underground fresh weight, chlorophyll content, and nitric nitrogen content, as well as the activities of several stress-resistance enzymes, including superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), polyphenol oxidase (PPO), and ascorbate oxidase (AAO). In addition, the plants inoculated with Trichoderma showed decreased cell membrane permeability and malondialdehyde (MDA) content in the leaves. Together, our results suggest that T. asperellum 525, T. harzianum 610, and T. pseudokoningii 886 inoculations inhibit F. oxysporum infection, stimulate the metabolism in cucumbers, and enhance the activities of stress-resistance enzymes, which consequently promote the growth of cucumber plants, prevent cucumber fusarium wilt, and improve the yield and quality of cucumbers. T. harzianum is a commonly used biocontrol fungus, while few studies have focused on T. asperellum or T. koningense. In this study, strains of T. asperellum and T. pseudokoningii showed excellent plant disease prevention and growth promoting effects on cucumber, indicating that they also have great potential as biocontrol fungi.

Autonomous vehicle path tracking accuracy and vehicle stability can hardly be accomplished by one fixed control frame in various conditions due to the changing vehicle dynamics. This paper presents a model predictive control (MPC) path-tracking controller with switched tracking error, which reduces the lateral tracking deviation and maintains vehicle stability for both normal and high-speed conditions. The design begins by comparing the performance of three MPC controllers with different tracking error. The analyzing results indicate that in the steady-state condition the controller with the velocity heading deviation as the tracking error significantly improves the tracking accuracy. Meanwhile, in the transient condition, by substituting the steady-state sideslip for real-time sideslip to compute the velocity heading deviation, the tracking overshoot can be reduced. To combine the strengths of these two methods, an MPC controller with switched tracking error is designed to improve the performance in both steady-state and transient conditions. The regime condition of a vehicle maneuver and the switching instant are determined by a fuzzy-logic-based condition classifier. Both normal and aggressive driving scenarios with the vehicle lateral and longitudinal acceleration combination of 5 m/s2 and 8 m/s2 are designed to test the proposed controller through CarSim-Simulink platform. The simulation results show the improved performance of the MPC controller with switched tracking error both in tracking accuracy and vehicle stability in both scenarios.

This paper proposed an integrated conical conformal array antenna (CCAA) for versatile application to the unmanned aerial vehicles. The CCAA consists of five flexible linear gradient subarrays with a uniform circumferential arrangement around the conical surface. It is also embedded with a pyramid reflective back-cavity (PRBC) within the conical carrier. The implementation for the three different elements of the linear gradient subarray toward impedance match and high isolation was investigated, and their identity resonant frequency (9.8 GHz) principle was developed and demonstrated. Furthermore, the PRBC was presented to improve the radiation null of the elements. A numerical 5-bit phase shifter manipulating phase difference of 72° was then combined with an 8-way power divider to obtain a fixed beam with a half power bandwidth (HPBW) of less than 24°, which indicated the backward endfire direction (θ = 180°) in terms of three circumferential arrays (R#X). Finally, the measurements with the aid of the designed phase shifter and power divider (model SHPDW4-040140S) were conducted. The experimental results show one omnidirectional coverage (360°) in the H-plane through the switching working mode of the elements with a wide scanning solid angle (≥72°) when these elements of the subarray hold an identity resonant frequency and exhibit a uniform performance in the point-to-point communication. The measurements of a narrow HPBW of less than 27.5° and the gain over 10.7 dBi in the endfire direction of the three circumferential arrays show great potential in backward blind space detection simultaneously.

This paper presents an effective multi-sensor approach for improving the accuracy of laser scanner by using a tactile probe to perform rapid and accurate reverse engineering of complex objects. The proposed system is unique in that it includes not only the physical integration of the two digitizers but also their combination at the measurement information level. With the coordinate data acquired using the optical scanner, intelligent data segmentation and feature recognition algorithm are proposed to divide the original point set into geometric elements and free-form surfaces. The tactile probe is guided to re-measure each feature with a small number of sampling points. Then different data fusion algorithms are proposed to compensate the scanned data patches of geometric features and free-form features with the accurate tactile probing data. Finally, the compensated point data can be exploited for accurate reverse engineering of a CAD model. Through the fusion of different sensor's information, both sensors complement each other with their advantages. Experimental results show that for the measurement of geometric surface, the proposed method can improve the accuracy of optical measurement to the accuracy of contact measurement. For free-form surface measurement, the proposed method reduces the optical measurement error from +0.032/-0.019 mm to ±0.016 mm, and the standard deviation from 0.012 mm to 0.004 mm. The measurement efficiency of proposed method is 4.5 times higher than that of contact measurement alone.

Considering that industrial data exhibit nonlinearity, high dimensionality and inherent multiscale characteristics, this paper proposes an intelligent industrial process monitoring and fault diagnosis method based on the discrete wavelet transform and deep learning. First, the discrete wavelet transform is used to present the multiscale representation of the raw data. Second, a multiscale convolutional neural network is used to extract the features at each scale, and then the extracted multiscale features are fused by the long short-term memory network to further reduce useless information and retain useful information. Finally, softmax classification is performed. The proposed method has two advantages: 1) the hierarchical learning structure with multiple pairs of convolutional and pooling layers can effectively learn nonlinear, high-dimensional fault features; and 2) the multiscale feature learning scheme can capture complementary diagnosis information at different scales. Detailed comparative studies between the proposed method and conventional methods have been carried out through the Tennessee Eastman benchmark process and the p-xylene oxidation reaction process.

The color histogram is a statistical behavior for robust pattern search or matching; however, difficulties have arisen in using it to discriminate among similar objects. Our method, called absent color indexing (ABC), describes how to use absent or minor colors as a feature in order to solve problems while robustly recognizing images, even those with similar color features. The proposed approach separates a source color histogram into apparent (AP) and absent (AB) color histograms in order to provide a fair way of focusing on the major and minor contributions together. A threshold for this separation is automatically obtained from the mean color histogram by considering the statistical significance of the absent colors. After these have been separated, an inversion operation is performed to reinforce the weight of AB. In order to balance the contributions of the two histograms, four similarity measures are utilized as candidates for combination with ABC. We tested the performance of ABC in terms of the F-measure using different similarity measures, and the results show that it is able to achieve values greater than 0.95. Experiments on Mondrian random patterns verify the ability of ABC to distinguish similar objects by margin. The results of extensive experiments on real-world images and open databases are presented here in order to demonstrate that the performance of our relatively simple algorithm remained robust even in difficult cases.

Pulmonary hypertension (PH) is a critical and dangerous disease in cardiovascular system. Pulmonary vascular remodeling is an important pathophysiological mechanism for the development of pulmonary arterial hypertension. Pulmonary artery smooth muscle cell (PASMC) proliferation, hypertrophy, and enhancing secretory activity are the main causes of pulmonary vascular remodeling. Previous studies have proven that various active substances and inflammatory factors, such as interleukin 6 (IL-6), IL-8, chemotactic factor for monocyte 1, etc., are involved in pulmonary vascular remodeling in PH. However, the underlying mechanisms of these active substances to promote the PASMC proliferation remain to be elucidated. In our study, we demonstrated that PASMC senescence, as a physiopathologic mechanism, played an essential role in hypoxia-induced PASMC proliferation. In the progression of PH, senescence PASMCs could contribute to PASMC proliferation via increasing the expression of paracrine IL-6 (senescence-associated secretory phenotype). In addition, we found that activated mTOR/S6K1 pathway can promote PASMC senescence and elevate hypoxia-induced PASMC proliferation. Further study revealed that the activation of mTOR/S6K1 pathway was responsible for senescence PASMCs inducing PASMC proliferation via paracrine IL-6. Targeted inhibition of PASMC senescence could effectively suppress PASMC proliferation and relieve pulmonary vascular remodeling in PH, indicating a potential for the exploration of novel anti-PH strategies.

Prinsepia uniflora Batalin 1892 is a medicinal plant widely distributed in northwest China. In this study, we report and characterize the complete chloroplast (cp) genome sequence of P. uniflora. The entire sequence is 159,179 bp in length, consisting of the large single-copy region (LSC) and small single copy region (SSC) (87,239 and 19,180 bp, respectively); these two regions are separated by a pair of 26,380-bp inverted repeat (IR) regions. The genome contains 131 genes, including 86 protein-coding genes, 37 tRNA genes, and eight rRNA genes. The overall GC content of the genome is 36.7%. A phylogenetic tree constructed from 18 chloroplast genomes revealed that P. uniflora was clustered with Prinsepia sinensis and Prinsepia utilis, all of which belong to the genus Prinsepia, which is supported as a sister group by a moderate bootstrap support value of 55% with the Malus and Pyrus genera.

Single photon light detection and ranging (LiDAR) has the advantages of high angle and distance resolution, great concealment, a strong anti-active jamming capability, small volume, and light mass, and has been widely applied in marine reconnaissance, obstacle avoidance, chemical warfare agent detection, and navigation. With the rapid development of metamaterials, the performance of a single photon LiDAR system would be improved by optimizing the core devices in the system. In this paper, we first analyzed the performance index of the single photon LiDAR and discovered the potential of metamaterials in improving the system performance. Then, the influence of metamaterials on the core devices of the single photon LiDAR were discussed, including lasers, scanning devices, optical lenses, and single photon detectors. As a result, we have concluded that through effective light field modulation, metamaterial technology might enhance the performance innovation of the single photon LiDAR.

Anaplastic thyroid cancer (ATC) is a highly aggressive and the most lethal type of thyroid cancer. The standard-of-care for unresectable ATC is radiotherapy and chemotherapy, usually based on doxorubicin (Dox). However, most patients develop resistance shortly after treatment. To overcome the drug resistance, we synthesized the mesoporous organosilica nanoparticles (MONPs) loaded with Dox and stabilized the nanocomposites by bovine serum albumin (BSA). The surface area and pore volume of MONPs were 612.653 m2/g and 0.589 cm3/g. The loading capacity of Dox-MONPs reached 47.02%. Compared to Dox-MONPs and free Dox, BSA-Dox-MONPs had more durable tumor-killing power on both drug-sensitive cell line HTh74 and drug-resistant cell line HTh74R. The cellular uptake of BSA-Dox-MONPs was 28.14 and 65.53% higher than that of Dox-MONP in HTh74 and HTh74R. Furthermore, the BSA coating decreased the efflux rate of nanocomposites in HTh74 (from 38.95 to 33.05%) and HTh74R (from 43.03 to 32.07%). In summary, BSA-Dox-MONPs reversed the chemotherapy resistance of ATC cells via increased drug uptake and inhibited drug efflux, offering a promising platform for the treatment of chemo-resistant ATC.

The driver genes regulating T-cell infiltration are important for understanding immune-escape mechanisms and developing more effective immunotherapy. However, researches in this field have rarely been reported in hepatocellular carcinoma (HCC). In the present study, we identified cancer driver genes triggered by copy number alterations such as CDKN2B, MYC, TSC1, TP53, and GSK3B. The T-cell infiltration levels were significantly decreased in both HCC and recurrent HCC tissues compared with the adjacent normal liver tissues. Remarkably, we identified that copy number losses of MAX and TP53 were candidate driver genes that significantly suppress T-cell infiltration in HCC. Accordingly, their downstream oncogenic pathway, cell cycle, was significantly activated in the low T-cell infiltration HCC. Moreover, the chemokine-related target genes by TP53, which played key roles in T-cell recruitment, were also downregulated in HCC with TP53/MAX deletions, suggesting that copy number losses in MAX and TP53 might result in T-cell depletion in HCC via downregulating chemokines. Clinically, the T-cell infiltration levels and chemokines activity could accurately predict the response of sorafenib, and the prognostic outcomes in HCC. In conclusion, the systematic analysis not only facilitates identification of driver genes and signaling pathways involved in T-cell infiltration and immune escape, but also gains more insights into the functional roles of T cells in HCC.

Although the cases of endometrial carcinoma (EC) is gradually increasing across the world, its etiology and pathogenesis remain unknown. The present study is the first to define the role and biological function of circRNA hsa_circ_0075960 in the development and progression of EC. We first determined that hsa_circ_0075960 is aberrantly expressed in EC cells. Then, we uncovered that the downregulation of hsa_circ_0075960 suppressed cell proliferation and promoted cell apoptosis of EC cells, suggesting that hsa_circ_0075960 could inhibit the progression of EC in vitro . In addition, we identified that miR-361-3p was the direct target of hsa_circ_0075960. Further analysis revealed that hsa_circ_0075960 affected the development of EC via sponging miR-361-3p. Interestingly, we verified that the level of SH2B1 was controlled by the downregulation of hsa_circ_0075960 and that the negative effect caused by hsa_circ_0075960 could be reversed via miR-361-3p inhibition. Our cumulative results revealed that the novel tumor regulator hsa_circ_0075960 functioned as a sponge for miR-361-3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR-361-3p.

Objective To investigate the value of a notched unipolar electrogram (N-uniEGM) in confirming the origin of premature ventricular contractions originating from the ventricular outflow tract (VOT-PVC) during mapping and ablation procedures. Methods This retrospective study enrolled consecutive patients with symptomatic idiopathic frequent VOT-PVCs that underwent radiofrequency ablation. The characteristics of the uniEGM of the successful ablation targets were analysed. N-uniEGM was defined as the uniEGM presenting a QS morphology with ≥1 steep notches on the downstroke deflection. All patients were followed-up for 3 months post-ablation. Results The study enrolled 190 patients with a mean ± SD age of 49.0 ± 15.3 years. N-uniEGMs were recorded in 124 of 190 (65.3%) patients. The N-uniEGM distribution area was limited to a mean ± SD of 0.8 ± 0.4 cm 2 . N-uniEGM showed consistency with the outcomes of activation mapping and pace mapping. Patients with an N-uniEGM had an ablation success rate of 98.4% (122 of 124) and their ablation times were significantly shorter than those without an N-uniEGM (7.6 ± 3.8 s versus 15.8 ± 8.8 s, respectively). The sensitivity and specificity of N-uniEGM in predicting successful ablation of VOT-PVCs were 72.6% and 91.7%, respectively. Conclusion N-uniEGM was a highly specific and moderately sensitive predictor of successful radiofrequency ablation in patients with VOT-PVCs.

As the core device of the quantum information field, the single photon avalanche photodiode (SPAD) is a solid-state single photon detector with a pico-second level time-resolution, low bias voltage, high signal-to-noise ratio, and a low cost. However, the photon detection efficiency (PDE) of SPAD is not ideal. The traditional method is to optimize the device structure, while the dark count or time resolution characteristics of the device might be sacrificed. The metasurface integrated on SPADs provides a novel approach to achieving higher PDE. As a result, the SPAD device structure could be independently designed to realize a low dark count rate and a good time resolution. In this paper, many kinds of metasurface structures that could enhance the incident photons absorption, are analyzed. Those structures compatible with CMOS or other easily mass produced processes are attractive for revolutionary changes to conventional SPAD. As a result, a metasurface integrated SPAD would greatly push its applications in the field of quantum information, single photons imaging, life medicine, and other low-level light detections.

High levels of sustained load can lead to time-dependent failure of reinforced concrete (RC) members. This in turn may lead to collapse of all or part of a building. Design errors, construction errors, and material deterioration may lead to concrete elements being subjected to high levels of sustained loads well exceeding typical service loads. Plain concrete can experience compressive failure when subjected to a high sustained stress (over 75% of its short-term strength). However, there is a lack of knowledge about the time-dependent strength and stiffness characteristics of RC members under high sustained loads. This paper presents the results of experimental testing of simply supported shear-controlled RC beams under high sustained loads. Two series of beams, consisting of 4 and 5 beams, were tested at concrete ages of 67 to 543 days to represent in-service concrete structures. The applied sustained loads ranged from 82% to 98% of the short-term capacity and lasted for 24 to 52 days. Test results indicated that high sustained load may eventually lead to failure (collapse); however, the level of load needs to be very close (~98%) to the short-term capacity. Under sustained load, all specimens experienced increased deflection with over half of the deflection increase occurring in the first 24 h. The sustained load increased the deflection at shear failure by 190% on average. The increase in the beam deflection may allow for load redistribution in redundant structural systems. A sharp increase in deflection due to tertiary creep occurred in a short time (~2 min) before failure, indicating little warning of the impending failure.

ObjectiveTo investigate the prognostic value of t(11;14) for de novo multiple myeloma (MM) patients in novel agent era.MethodsA total of 455 patients with fluorescence in situ hybridization (FISH), before treatments from three hospitals in China, were included in the study. All patients received autologous stem cell transplantation (ASCT) after induction therapy as consolidation. High risk (HR) cytogenetics were defined as t(4;14), t(14;16), and/or del 17p.ResultsA total of 152 patients were in the HR group. Of patients without HR cytogenetics, 55 were in the t(11;14) group, and 248 were in the standard risk (SR) group without t(11;14). Gain in 1q21 was observed in 38.9% patients with t(11;14). There were no differences in median progression free survival (PFS) and overall survival (OS), respectively, between patients in the t(11;14) group and those in the SR group. Patients in the t(11;14) group had the longer median PFS and OS, respectively, compared with those in the HR group. Regardless of coexisting with 1q21 gain or not, patients in the t(11;14) group still had similar median PFS and OS compared to those in the SR group. Finally, multivariate analysis indicated that including 1q21 gain and bone marrow plasma cell with CD20 expression, no variables were found to predict the outcome of the t(11;14) group in our cohort.ConclusionsThese results confirm that outcomes of t(11;14) MM are similar to standard risk patients when they receive novel agent induction therapy consolidated by ASCT. Gain of 1q21 coexists with t(11;14) frequently. In addition, both bone marrow plasma cell with CD20 expression and 1q21 gain have no impact on median PFS or OS for patients with t(11;14).

BackgroundExtranodal natural killer/T-cell lymphoma (ENKTL) is a rare and extremely malignant tumor. The systemic inflammation score (SIS), which is based on the pretreatment level of lymphocyte-to-monocyte ratio (LMR) and serum albumin (Alb), has been shown to be of prognostic value in a number of cancers. We integrate several other pretreatment serum inflammatory indicators, including the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), serum C-reactive protein (CRP) and albumin (Alb) level, to establish a modified systemic inflammatory scoring system to predict clinical outcomes of ENKTL.MethodsA total of 184 patients with newly diagnosed ENKTL was retrospectively investigated. Systemic inflammatory indexes, including NLR, LMR, CRP, and Alb level were reviewed. Receiver operating characteristic (ROC) curve analysis was carried out to obtain the optimal cut-off value. The associations between cutoff values and overall survival (OS) were analyzed by Kaplan–Meier curves and Cox proportional models.ResultsThe median age of patients was 44.0 years, ranging from 15 to 82 years. There were 129 (70.1%) male patient. About 57.1% of patients had stage III or IV disease. The optimal cut-off values of NLR and LMR in predicting OS were 3.1 and 2.4, respectively. The clinical standard of CRP and Alb levels at 10 and 40 mg/L, respectively, were chosen as the optimal cut-off values. By multivariate analysis, hemophilic syndrome (hazard ratio [HR]: 10.540, 95% confidence interval [CI]: 3.440–32.291, P < 0.001), advanced Ann Arbor stages (III–IV) (HR: 4.606, 95% CI: 1.661–12.774, P = 0.003), paranasal sinus invasion (HR: 2.323, 95% CI: 1.069–5.047, P = 0.033), NLR ≥ 3.1 (HR: 3.019, 95% CI: 1.317–6.923, P = 0.009), Alb level of

A 70-year-old woman with symptomatic bradycardia caused by persistent atrial fibrillation and atrioventricular block was referred to our institution for pacemaker implantation. After we failed to obtain adequate His bundle capture thresholds (>2.5 V at 1.0 ms) at three pacing sites, left bundle branch pacing was attempted as an alternative technique. The tip of the 3830 lead was screwed towards the left side of the interventricular septum. Contrast medium was injected through the C315 sheath, which was placed close to the right side of the interventricular septum to determine the exact depth of the 3830 lead inside the septum. Unexpectedly, the vessels in the interventricular septum were revealed by the contrast, which showed that the lead had penetrated one of the septal vessels. To the best of our knowledge, this is the first reported case of a patient in whom injection of a contrast agent through a delivery sheath showed damage to the interventricular septal vessels. Findings from this case suggest that injection of contrast medium through a C315 sheath that is placed close to the interventricular septum is a potential method for excluding damage to interventricular septal vessels.

Purpose: Metastatic nasopharyngeal carcinoma (mNPC) remains incurable. This prospective study aimed to investigate whether adding cetuximab to cisplatin-based induction therapy could improve efficacy and survival for chemotherapy-naïve mNPC patients.Patients and Methods: Eligible chemotherapy-naïve mNPC patients were enrolled, including those initially diagnosed with mNPC (IM) and those with first-relapse metastases after radiotherapy (RM). Patients all received induction chemotherapy (IC) including docetaxel and cisplatin plus cetuximab. Those who obtained objective remission after IC would continue to receive radiotherapy concurrent with cetuximab and cisplatin, and further capecitabine as maintenance. Contemporaneous patients who received conventional therapy served as controls.Results: Forty-three patients were enrolled, including 17 IM and 26 RM patients. Thirty-nine (90.7%) patients had WHO III subtype. The overall response and complete response (CR) rates were, respectively, 79.1 and 34.9% after induction therapy and 76.7 and 46.5% after chemoradiotherapy. The 5-year overall survival (OS) and progression-free survival (PFS) rates reached 34.9 and 30%, respectively. Subgroup analysis showed that compared with RM patients, IM patients had a higher 5-year OS (58.8 vs. 19.2%) and PFS (52.9 vs. 19.2%). The IM group had a higher CR rate of induction treatment than the RM group (52.9 vs. 23.1%). No treatment-related death was observed. Twelve patients (27.9%) remained alive with disease-free survival times from 60+ to 135+ months. Control patients showed a substantially lower survival rate (5-year OS, 10.9%) and few long-term survivors.Conclusions: This regimen resulted in significantly improved efficacy and survival, which indicates a potentially curative role for chemotherapy-naïve mNPC, especially in newly diagnosed patients. A phase III clinical trial (NCT02633176) is ongoing for confirmation.

Background: Perfluoroalkyl substances (PFASs) were reported to be associated with hypertensive disorders of pregnancy (HDP) but the results were inconsistent and prospective data are scarce. We aimed to examine these associations in a large prospective birth cohort study in Shanghai, China. Methods: A total of 10 PFASs were measured by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS-MS) in the plasma samples from 3220 women who were enrolled during early pregnancy and gave birth to a singleton live birth between 2013 and 2016. The outcomes included gestational hypertension (GH), preeclampsia (PE) and overall HDP. Associations of these outcomes with each PFASs were estimated by multivariable logistic regression and expressed as odd ratios (ORs) and 95% confidence intervals (95% CIs). Potential non-linear association between PFASs and HDP was examined with restricted cubic spline model. To handle the potential confounding by correlated PFASs, we applied elastic net regression (ENR) to identify independent PFASs components of outcomes. Results: Among all singleton live births, the incidence rates of GH and PE were 2.0% and 2.2%, respectively. Overall, PFASs did not show a significant and consistent pattern of the associations with GH, PE or overall HDP, both before and after controlling for potential confounders. ENR model confirmed the results that there was no independently predictive role of PFASs on GH, PE or overall HDP. Conclusions: In this large prospective cohort study, maternal plasma concentration of PFASs in early pregnancy were not associated with GH, PE or overall HDP in singleton livebirths. Keywords: Perfluoroalkyl substances, Gestational hypertension, Preeclampsia, Hypertensive disorders of pregnancy

We herein describe a 33-year-old woman with a mechanical aortic and mitral valve who developed repetitive monomorphic ventricular tachycardia with unstable hemodynamics. Catheter ablation by direct puncture at the left ventricular apex through a minithoracotomy successfully terminated the ventricular tachycardia, which had originated from the apical-septal endocardium in the left ventricle, despite the hindrance to routine access. No procedure-related complications or recurrence of the clinical ventricular tachycardia developed during a 66-month follow-up, demonstrating that endocardial ablation through direct cardiac cavity puncture can be considered in select cases.

In this paper, a robust angle estimator for uncorrelated targets that employs a compressed sense (CS) scheme following a fast greedy (FG) computation is proposed to achieve improved computational efficiency and performance for the bistatic MIMO radar with unknown gain-phase errors. The algorithm initially avoids the wholly computation of the received signal by compiling a lower approximation through a greedy Nyström approach. Then, the approximated signal is transformed into a sparse signal representation where the sparsity of the target is exploited in the spatial domain. Finally, a CS method, Simultaneous Orthogonal Matching Pursuit with an inherent gradient descent method, is utilized to reconstruct the signal and estimate the angles and the unknown gain-phase errors. The proposed algorithm, aside achieving closed-form resolution for automatically paired angle estimation, offers attractive computational competitiveness, specifically in large array scenarios. Additionally, the analyses of the computational complexity and the Cramér–Rao bounds for angle estimation are derived theoretically. Numerical experiments demonstrate the improvement and effectiveness of the proposed method against existing methods.

In the original model reference adaptive induction motor speed sensorless system based on flux linkage, there is a large fluctuation of the rotational speed in transient and steady state. When the motor speed is estimated, the integral part of voltage model affects the accuracy of the estimated speed with high-frequency signals and noise. In order to solve the above problems and further improve the system’s anti-interference performance and the speed estimation accuracy at low speed, an improved method of speed estimation that combines fuzzy proportional integral control and sliding mode control is proposed, by adopting genetic algorithm to optimize the parameters of the three sliding mode controllers, meanwhile, using the error integration criterion as the objective function of genetic algorithm optimization and searching for the optimal value of the objective function. Compared to the conventional method, the simulation results show the effectiveness of the proposed method in the middle- and low-speed regions with improved robustness against external disturbance, also display the high accuracy of estimated speed, the minor amplitude and frequency of speed fluctuation, and the great dynamic performance indexes of the system.

Persistent luminescence (PerL) phosphors have been widely applied in many advanced applications in the field of emergency lighting, safety signage, and ornaments. Recently, the PerL phosphors based on germanates have attracted great attention owing to their excellent PerL performance. However, the design and development of excellent germanates-based PerL materials with full spectral emissions remain challenging due to the lack of color-tunable PerL, especially in the blue and green regions (400–600 nm). Herein, we develop a new type of Tb ^3+ -activated LiYGeO _4 PerL phosphor with real-time adjusting the photoluminescence (PL) and PerL color, which can be effectively excited by a 254 UV light. Both blue and green PerL are realized simultaneously in a single phosphor. When LiYGeO _4 :Tb ^3+ doped with lower concentrations of Tb ^3+ ions, phosphors emit blue PL and PerL. With increasing Tb ^3+ concentration, the PL and PerL colors of LiYGeO _4 :Tb ^3+ PerL phosphor are gradually regulated from blue to green. Besides, LiYGeO _4 :Tb ^3+ exhibits temperature-dependent luminescence property, whose PL and PerL colors can also be successively widely tuned by various temperature. This stable and tunable color in real-time PL and PerL property promote the as-designed LiYGeO _4 :Tb ^3+ phosphor to have potential applications in advanced anti-counterfeiting and display devices.

Abstract Background Stable angina is a common cardiovascular disease with high mortality and a poor prognosis. Although there are various interventions against stable angina, none are able to significantly reduce the mortality rate. Guanxinjing capsule (GXJ) is made from the classical Chinese prescription Xuefuzhuyutang (血府逐瘀汤). Both basic research and clinical studies have shown that GXJ can relieve the symptoms of angina, but currently, the effects of GXJ lack high-quality clinical evidence. The aim of this study was to evaluate the clinical effectiveness and safety of GXJ compared with placebo. Methods/design This multicentre, blinded, randomized trial will be conducted with a total of 120 participants diagnosed with chronic stable angina (Qi deficiency and blood stasis syndrome). Using a central randomization system, participants will be randomized (1:1) into groups receiving either GXJ or placebo for 8 weeks. After a 2-week run-in period, eligible patients will receive either GXJ or placebo (4 pills, three times daily) for 8 weeks in addition to conventional treatment. The primary outcomes include changes in the total exercise time on exercise tolerance tests and changes in the integral scores of angina symptoms. The secondary outcome measures include changes in the maximal estimated workload, changes in time to a 1 mm ST-segment depression or raise, changes in the time to onset of angina during exercise tolerance testing, changes in the total score of traditional Chinese medicine syndrome, and changes in the total score of the Generalized Anxiety Disorder 7-item assessment between baseline and week 8. Other outcome measures will also be assessed. All exercise tolerance tests use a standard Bruce multistage exercise test protocol. Adverse events will be monitored throughout the trial. Discussion This study will investigate whether GXJ can alleviate clinical symptoms, increase the angina-free walking time, and improve quality of life in patients with chronic stable angina (Qi deficiency and blood stasis syndrome). The results of this study will provide clinical evidence for the application of GXJ to the treatment of stable angina. Trial registration Chinese Clinical Trial Registry, ChiCTR1800014258. Registered on 2 January 2018.

Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during development.

Abstract Background Conotruncal heart defects (CTDs) are a subgroup of congenital heart defects that are considered to be the most common type of birth defect worldwide. Genetic disturbances in folate metabolism may increase the risk of CTDs. Methods We evaluated five single-nucleotide polymorphisms (SNPs) in genes related to folic acid metabolism: methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), solute carrier family 19, member 1 (SLC19A1 G80A), methionine synthase (MTR A2576G), and methionine synthase reductase (MTRR A66G), as risk factors for CTDs including various types of malformation, in a total of 193 mothers with CTD-affected offspring and 234 healthy controls in a Chinese population. Results Logistic regression analyses revealed that subjects carrying the TT genotype of MTHFR C677T, the C allele of MTHFR A1298C, and the AA genotype of SLC19A1 G80A had significant 2.47-fold (TT vs. CC, OR [95% CI] = 2.47 [1.42–4.32], p = 0.009), 2.05–2.20-fold (AC vs. AA, 2.05 [1.28–3.21], p = 0.0023; CC vs AA, 2.20 [1.38–3.58], p = 0.0011), and 1.68-fold (AA vs. GG, 1.68 [1.02–2.70], p = 0.0371) increased risk of CTDs, respectively. Subjects carrying both variant genotypes of MTHFR A1298C and SLC19A1 G80A had a higher (3.23 [1.71–6.02], p = 0.0002) increased risk for CTDs. Moreover, the MTHFR C677T, MTHFR A1298C, and MTRR A66G polymorphisms were found to be significantly associated with the risk of certain subtypes of CTD. Conclusions Our data suggest that maternal folate-related SNPs might be associated with the risk of CTDs in offspring.

Letter to the Editor

Abstract Background Tumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia-activated prodrug that selectively targets the hypoxic regions of solid tumors. As hypoxia-inducible factor-1α (HIF-1α) is overexpressed in nasopharyngeal carcinoma (NPC) tissues, we performed the present study to evaluate the efficacy profile of evofosfamide in NPC. Methods We evaluated the efficacy of evofosfamide as a single agent or combined with cisplatin (DDP) in the NPC cell lines CNE-2, HONE-1 and HNE-1, and in nude mouse xenograft tumor models. Results Evofosfamide exhibited hypoxia-selective cytotoxicity in NPC cell lines, with 50% inhibition concentration (IC50) values of 8.33 ± 0.75, 7.62 ± 0.67, and 0.31 ± 0.07 μmol/L under hypoxia in CNE-2, HONE-1 and HNE-1 cells, respectively. The sensitization ranged from ninefold to greater than 300-fold under hypoxia compared with normoxia controls. The combination of evofosfamide with DDP had a synergistic effect on cytotoxicity in the NPC cell lines by combination index values assessment. Cell cycle G2 phase was arrested after treated with 0.05 μmol/L evofosfamide under hypoxia. Histone H2AX phosphorylation (γH2AX) (a marker of DNA damage) expression increased while HIF-1α expression suppressed after evofosfamide treatment under hypoxic conditions. In the HNE-1 NPC xenograft models, evofosfamide exhibited antitumor activity both as a single agent and combined with DDP. Hypoxic regions in xenograft tissue were reduced after both evofosfamide monotherapy and combined therapy with DDP. Conclusions Our results present preclinical evidence for targeting the selective hypoxic portion of NPC by evofosfamide as a single agent and combined with DDP and provide rationale for the potential clinical application of evofosfamide for the treatment of nasopharyngeal carcinoma.

The complete cp genome of Cerasus dictyoneura was 158,084 bp in length, consisting of a LSC of 86,275 bp and a SSC of 19,039 bp, which were separated by a pair of 26,385 bp IRs. The genome contained 131 genes, including 86 proteincoding genes, 37 tRNA genes, and 8 rRNA genes. The overall GC content is 36.7%, while the corresponding values of the LSC, SSC, and IR regions are 34.6, 29.5, and 42.6%, respectively. Furthermore, phylogenetic analysis based on 16 complete cp genome sequences indicated that C. dictyoneura is within Eurosids I.

Purpose: To investigate the changes and underlying mechanisms in parents' safety awareness and the use of child safety seats after the mandatory legislation in Shanghai city, China. Methods: This study was carried out by Shanghai Key Laboratory of Environment and Children's Health using a multi-stage, simple random sampling method. Volunteers with children aged 0–12 months were recruited. Child safety seats were sent to each volunteer's family. Telephone encounters and/or on-site visits were used to collect data from parents using a phased survey on children's safety during car use. Results: Among all respondents, 91.2% had heard of motor vehicle accidents involving children, and 97.2% could describe the appropriate use of a safety seat to minimize the risk of child injury in a collision. Among 1078 families with newborns, awareness of child safety seats was 91.9%. There were 86% patients aware that new laws and regulations have been released regarding the use of child safety seats, and 98.5% of them plan to comply with the new laws. Moreover, 61% patients think that taxis should be routinely equipped with child safety seats. Conclusion: The parents in Shanghai obtained a high level of awareness of children's traffic safety after the introduction of child safety seats legislation, and had a positive experience related to the use of child safety seats. Taxi may be an important area of focus for implementation of child traffic safety. Traffic safety laws and regulations with further impact should be continuously studied. Keywords: Child, Child restraint systems, Traffic injuries, Awareness, Shanghai

This paper presents a novel method that absorbs the strong discriminative ability from absent color indexing (ABC) to enhance sensitivity and combines it with a correlation filter (CF) for obtaining a higher precision; this method is named ABC-CF. First, by separating the original color histogram, apparent and absent colors are introduced. Subsequently, an automatic threshold acquisition is proposed using a mean color histogram. Next, a histogram intersection is selected to calculate the similarity. Finally, CF follows them to solve the drift caused by ABC during the matching process. The novel approach proposed in this paper realizes robustness in distortion of target images and higher margins in fundamental matching problems, and then achieves more precise matching in positions. The effectiveness of the proposed approach can be evaluated in the comparative experiments with other representative methods by use of the open data.

Improved OLED systems have great potential for next-generation display applications. Carbon nanotubes (CNTs) and the conductive polymers poly (3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT: PSS) have attracted great interest for advanced applications, such as optoelectronic products. In this paper, the simultaneous enhancement of the conductivity, roughness, and adhesion properties of transparent conductive films with PEDOT: PSS/CNTs is reported. These films prepared by a simple spin-coating process were successfully used to produce high-performance organic light-emitting diodes (OLEDs) with an improved lifetime. Addition of PEDOT: PSS lowered the film sheet resistance and CNTs helped to enhance the stability and maintain the lifetime of the OLEDs. In addition, treatment with methanol and nitric acid changed the morphology of the polymer film, which led to greatly reduced sheet resistance, enhanced substrate adhesion, and reduced film roughness. The best performance of the film (PEDOT: PSS: CNT = 110: 1, W/W) was 100.34 Ω/sq.@ 90.1 T%. High transmittance, low sheet resistance, excellent adhesion, and low roughness (3.11 nm) were achieved synchronously. The fabricated OLED demonstrated a low minimum operating voltage (3 V) and could endure high voltage (20 V), at which its luminance reached 2973 cd/m2. Thus, the incorporation of CNTs within PEDOT: PSS electrodes has great potential for the improvement of the performance of OLED devices.

It is challenging to accurately judge the actual end position of the manipulator—regarded as a rigid body—due to the influence of micro-deformation. Its precise and efficient control is a crucial problem. To solve the problem, the Hamilton principle was used to establish the partial differential equation (PDE) dynamic model of the manipulator system based on the infinite dimension of the working environment interference and the manipulator space. Hence, it resolves the common overflow instability problem in the micro-deformable manipulator system modeling. Furthermore, an infinite-dimensional radial basis function neural network compensator suitable for the dynamic model was proposed to compensate for boundary and uncertain external interference. Based on this compensation method, a distributed boundary proportional differential control method was designed to improve control accuracy and speed. The effectiveness of the proposed model and method was verified by theoretical analysis, numerical simulation, and experimental verification. The results show that the proposed method can effectively improve the response speed while ensuring accuracy.

Ginkgo biloba L. has always been a popular area of research due to its various active ingredients and pharmacological effects. Ginkgo biloba is rich in ginkgo flavonoids, ginkgolides, and ginkgolic acid, with anti-inflammation, antioxidation, neuroprotection, anti-platelet agglutination, hypolipidemic effect, anti-cancer, and anti-radiation properties. There are many methods to extract and separate the active components of ginkgo. Among them, supercritical carbon dioxide fluid extraction (SFE-CO2) is known for its green, clean, and environment-friendly properties. In this paper, the pharmacological activities, the active components, and structures of different parts of ginkgo, the extraction methods of its effective ingredients, and the application of the SFE-CO2 method for the extraction and separation of active ingredients in Ginkgo biloba from leaves, seeds, pollen, and roots were reviewed, in order to make best use of ginkgo resources, and provide support and references for the development of SFE-CO2 of active components from Ginkgo biloba.

In this paper, the dynamic programming algorithm is applied to the control strategy design of parallel hybrid electric vehicles. Based on MATLAB/Simulink software, the key component model and controller model of the parallel hybrid system are established, and an offline simulation platform is built. Based on the platform, the global optimal control strategy based on the dynamic programming algorithm is studied. The torque distribution rules and shifting rules are analyzed, and the optimal control strategy is adopted to design the control strategy, which effectively improves the fuel economy of plug-in hybrid electric vehicles. The fuel consumption rate of this parallel hybrid electric vehicle is based on china city bus cycle (CCBC) condition.

Aqueous zinc-ion batteries (AZIBs) are promising candidates for large-scale energy storage because of their low cost and high safety. However, their practical applications are impeded by low energy density and short service life. Here, an aqueous Zn2+/Li+ hybrid-ion battery is fabricated using the LiV3O8 nanorods as the cathode, metallic Zn as the anode, and 3 M Zn(OTf)2 + 0.5 M LiOTf aqueous solution as the electrolyte. Compared with the batteries using pure 3 M Zn(OTf)2 electrolyte, the cycle performance of the hybrid-ion battery is significantly improved. After 4000 cycles at 5 A g1, the remaining capacity is 163.9 mA h g−1 with impressive capacity retention of 87.0%. Ex-situ XRD, ex-situ XPS, and SEM tests demonstrate that the hybrid electrolyte can inhibit the formation of the irreversible Zn3(OH)2V2O7·2H2O by-product and restrict Zn dendrite growth during cycling, thereby improving the cycle performance of the batteries.

Comparative analysis of fermented and unfermented soybean lipid were performed by supercritical CO2 extraction (SC-CO2), GC, RP-HPLC-ELSD/APCI-MS techniques, which caused to tentatively identify 31 lipids, determine fatty acid composition and lipid classes contents. Major observations were that there were significant variations of fatty acid composition involved in the amounts of palmitic acid and oleic acid increased (p

The complete mitochondrial (mt) genome of sinistral Neptunea cumingii was determined using genome walking techniques in this study. The total length of the mt genome sequence of sinistral N. cumingii was 15,254 bp, including 13 protein-coding genes, 23 transfer RNA genes, and 2 ribosomal RNA genes. The overall composition of the mitogenome was estimated to be 30.77% for A, 38.46%% for T, 15.57% for C and 15.20% for G, respectively, indicating that an A + T (45.97%)-rich feature occurs in the sinistral N. cumingii mitogenome. The phylogenetic relationships of 13 mollusk species were constructed based on the complete mtDNA sequences by the neighbor-joining method using MEGA 7.0 and DNAMAN 6.0 software.

The complete mitochondrial (mt) genome of Nassarius gregarius was determined using genome walking techniques in this study. The total length of the mt genome sequence of N. gregarius was 15,169 bp, including 13 protein-coding genes, 23 transfer RNA genes, and 2 ribosomal RNA genes. The overall composition of the mitogenome was estimated to be 30.46% for A, 39.54%% for T, 14.38% for C, and 15.52% for G, indicating that an A + T (70.00%)-rich feature occurs in the N. gregarius mitogenome. The phylogenetic relationships of 13 mollusk species were constructed based on the complete mtDNA sequences by the neighbor-joining method using MEGA 7.0 and DNAMAN 6.0 software.

The complete mitochondrial (mt) genome of Lunella coronata correensis was determined using genome walking techniques in this study. The total length of the mt genome sequence of L. coronata correensis was 16,551 bp, including 13 protein-coding genes, 23 transfer RNA genes, and 2 ribosomal RNA genes. The overall composition of the mitogenome was estimated to be 33.1% for A, 35.3% for T, 13.7% for C, and 19.9% for G, respectively, indicating that an A + T (68.4%)-rich feature occurs in the L. coronata correensis mitogenome. The phylogenetic relationships of 12 mollusk species were constructed based on the complete mtDNA sequences by the neighbor-joining method using MEGA version 7.0 and DNAMAN version 6.0 software.

Abstract Background The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival (OS) of non-metastatic nasopharyngeal carcinoma (NPC) patients after curative treatments. Methods We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003. The clinical data of a separate cohort of 464 patients who received intensity-modulated radiation therapy (IMRT) between 2001 and 2010 were also retrieved to examine the extensibility of the model. Cox regression analysis was used to identify the prognostic factors for building the nomogram. The predictive accuracy and discriminative ability were measured using the concordance index (c-index). Results We identified and incorporated 12 independent clinical factors into the nomogram. The calibration curves showed that the prediction of OS was in good agreement with the actual observation in the internal validation set and IMRT cohort. The c-index of the nomogram was statistically higher than that of the 7th edition TNM staging system for predicting the survival in both the primary cohort (0.69 vs. 0.62) and the IMRT cohort (0.67 vs. 0.63). Conclusion We developed and validated a novel nomogram that outperformed the TNM staging system in predicting the OS of non-metastatic NPC patients who underwent curative therapy.