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151. The Effect of Depression on Health-Related Quality of Life Is Mediated by Fatigue in Persons with Multiple Sclerosis

Author

Rodgers, Stephanie, Manjaly, Zina-Mary, Calabrese, Pasquale, Steinemann, Nina, Kaufmann, Marco; https://orcid.org/0000-0002-4810-7734, Salmen, Anke, Chan, Andrew, Kesselring, Jürg, Kamm, Christian P, Kuhle, Jens, Zecca, Chiara, Gobbi, Claudio, von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797, Ajdacic-Gross, Vladeta, Rodgers, Stephanie, Manjaly, Zina-Mary, Calabrese, Pasquale, Steinemann, Nina, Kaufmann, Marco; https://orcid.org/0000-0002-4810-7734, Salmen, Anke, Chan, Andrew, Kesselring, Jürg, Kamm, Christian P, Kuhle, Jens, Zecca, Chiara, Gobbi, Claudio, von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797, and Ajdacic-Gross, Vladeta

Abstract

The interrelations between fatigue, depression and health-related quality of life (HRQoL) in persons with multiple sclerosis (PwMS) are complex, and the directionality of the effects is unclear. To address this gap, the current study used a longitudinal design to assess direct and indirect effects of fatigue and depression on HRQoL in a one-year follow-up survey. A sample of 210 PwMS from the nationwide Swiss MS Registry was used. HRQoL was assessed using the European Quality of Life 5-Dimension 5-Level questionnaire. Path analysis on HRQoL, with fatigue and depression as predictors, was applied. Fatigue was measured by the Modified Fatigue Impact Scale (MFIS), including physical, cognitive and psychosocial subscales, and non-somatic depressive symptomatology was examined with the Beck Depression Inventory-Fast Screen (BDI-FS). Fatigue acted as a fully mediating variable (B = −0.718, SE = 0.253) between non-somatic depressive symptomatology and HRQoL. This indirect effect became apparent in the physical (B = −0.624, SE = 0.250), psychosocial (B = −0.538, SE = 0.256) and cognitive subscales (B = −0.485, SE = 0.192) of fatigue. In contrast, non-somatic depressive symptomatology did not act as a mediator. Our findings provide novel and clinically relevant longitudinal evidence showing that the debilitating effect of non-somatic aspects of depression on HRQoL was fully mediated and therefore explainable via fatigue.

Published
2021

152. Onset Symptom Clusters in Multiple Sclerosis: Characteristics, Comorbidities, and Risk Factors

Author

Ajdacic-Gross, Vladeta, Steinemann, Nina, Horváth, Gábor, Rodgers, Stephanie, Kaufmann, Marco, Xu, Yanhua, Kamm, Christian P, Kesselring, Jürg, Manjaly, Zina-Mary, Zecca, Chiara, Calabrese, Pasquale, Puhan, Milo A, von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797, Ajdacic-Gross, Vladeta, Steinemann, Nina, Horváth, Gábor, Rodgers, Stephanie, Kaufmann, Marco, Xu, Yanhua, Kamm, Christian P, Kesselring, Jürg, Manjaly, Zina-Mary, Zecca, Chiara, Calabrese, Pasquale, Puhan, Milo A, and von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797

Abstract

Background: Multiple sclerosis (MS) symptoms are expected to aggregate in specific patterns across different stages of the disease. Here, we studied the clustering of onset symptoms and examined their characteristics, comorbidity patterns and associations with potential risk factors.Methods: Data stem from the Swiss Multiple Sclerosis Registry, a prospective study including 2,063 participants by November 2019. MS onset symptoms were clustered using latent class analysis (LCA). The latent classes were further examined using information on socio-demographic characteristics, MS-related features, potential risk factors, and comorbid diseases.Results: The LCA model with six classes (frequencies ranging from 12 to 24%) was selected for further analyses. The latent classes comprised a multiple symptoms class with high probabilities across several symptoms, contrasting with two classes with solitary onset symptoms: vision problems and paresthesia. Two gait classes emerged between these extremes: the gait-balance class and the gait-paralysis class. The last class was the fatigue-weakness-class, also accompanied by depression symptoms, memory, and gastro-intestinal problems. There was a moderate variation by sex and by MS types. The multiple symptoms class yielded increased comorbidity with other autoimmune disorders. Similar to the fatigue-weakness class, the multiple symptoms class showed associations with angina, skin diseases, migraine, and lifetime prevalence of smoking. Mononucleosis was more frequently reported in the fatigue-weakness and the paresthesia class. Familial aggregation did not differ among the classes.Conclusions: Clustering of MS onset symptoms provides new perspectives on the heterogeneity of MS. The clusters comprise different potential risk factors and comorbidities. They point toward different risk mechanisms.

Published
2021

153. Impact on monthly migraine days of discontinuing anti-CGRP antibodies after one year of treatment - a real-life cohort study

Author

Gantenbein, Andreas R, Agosti, Reto, Gobbi, Claudio, Flügel, Dominique, Schankin, Christoph J; https://orcid.org/0000-0003-4668-6098, Viceic, Dragana, Zecca, Chiara, Pohl, Heiko; https://orcid.org/0000-0002-2778-6790, Gantenbein, Andreas R, Agosti, Reto, Gobbi, Claudio, Flügel, Dominique, Schankin, Christoph J; https://orcid.org/0000-0003-4668-6098, Viceic, Dragana, Zecca, Chiara, and Pohl, Heiko; https://orcid.org/0000-0002-2778-6790

Abstract

OBJECTIVE This study aims to analyse the effect of the discontinuation of anti-calcitonin gene-related peptide antibodies on monthly migraine days after 12 treatment months. BACKGROUND Anti-calcitonin gene-related peptide antibodies have been a game changer in migraine prophylaxis. However, high treatment costs warrant reducing treatment duration to the essential minimum. METHODS We collected data of patients with migraine who had received anti-calcitonin gene-related peptide antibodies and had received treatment for 12 months. RESULTS We included 52 patients. The average number of monthly migraine days was 16 ± 7 days at baseline, 6 ± 6 in the third, and 5 ± 4 in the 12th treatment month. After treatment interruption, the number of monthly migraine days was 6 ± 4 days in the first month, 9 ± 4 days in the second, and 11 ± 5 days in the third month. Most patients (88.9%) restarted treatment. CONCLUSION Only little of the therapeutic effect of anti-calcitonin gene-related peptide antibodies outlasts their pharmacological effect. After treatment interruption, migraine frequency rose in most patients, and prophylaxis was required again in most cases.Limiting treatment to benefitting patients and confirming the need for prophylaxis periodically is reasonable. However, our data does not support the need for prescheduled treatment discontinuation after 12 months and a fixed duration of the treatment interruption of 3 months.

Published
2021

155. Vitamin D and IFN-β Modulate the Inflammatory Gene Expression Program of Primary Human T Lymphocytes

Author

Bianchi, Niccolò, Emming, Stefan, Zecca, Chiara, and Monticelli, Silvia

Subjects
Inflammation, T-Lymphocytes, Immunology, vitamin D, Interferon-beta, Vitamins, human T lymphocytes, microRNAs, Multiple Sclerosis, Relapsing-Remitting, Gene Expression Regulation, plasticity, gene expression, Immunology and Allergy, Humans, IFN-β, Cells, Cultured, Original Research, Cell Proliferation
Abstract

IFN-β treatment is a commonly used therapy for relapsing-remitting multiple sclerosis (MS), while vitamin D deficiency correlates with an increased risk of MS and/or its activity. MS is a demyelinating chronic inflammatory disease of the central nervous system, in which activated T lymphocytes play a major role, and may represent direct targets of IFN-β and vitamin D activities. However, the underlying mechanism of action of vitamin D and IFN-β, alone or in combination, remains incompletely understood, especially when considering their direct effects on the ability of T lymphocytes to produce inflammatory cytokines. We profiled the expression of immune-related genes and microRNAs in primary human T lymphocytes in response to vitamin D and IFN-β, and we dissected the impact of these treatments on cytokine production and T cell proliferation. We found that the treatments influenced primarily memory T cell plasticity, rather than polarization toward a stable phenotype. Moreover, our data revealed extensive reprogramming of the transcriptional output of primary T cells in response to vitamin D and IFN-β and provide the bases for further mechanistic insights into these commonly used treatments.

Published
2020

161. Characterizing 1-Year Development of Cervical Cord Atrophy Across Different Ms Phenotypes: A Voxel-Wise, Multicenter Analysis (2563)

Author

Rocca, Maria A., primary, Valsasina, Paola, additional, Gobbi, Claudio, additional, Zecca, Chiara, additional, Rovira, Alex, additional, Montalban, Xavier, additional, Kearney, Hugh, additional, Ciccarelli, Olga, additional, Matthews, Lucy, additional, Palace, Jacqueline, additional, Gallo, Antonio, additional, Bisecco, Alvino, additional, Gass, Achim, additional, Eisele, Philipp, additional, and Filippi, Massimo, additional

Published
2021
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164. Predictors of Care Home Admission and Survival Rate in Patients With Syndromes Associated With Frontotemporal Lobar Degeneration in Europe

Author

Borroni, Barbara, Tarantino, Barbara, Graff, Caroline, Krüger, Johanna, Ludolph, Albert C., Moreno, Fermin, Otto, Markus, Rowe, James B., Seelaar, Harro, Solje, Eino, Stefanova, Elka, Traykov, Latchezar D., Jelic, Vesna, Anderl-Straub, Sarah, Portaankorva, Anne M., Barandiaran, Myriam, Gabilondo, Alazne, Murley, Alexander G., Rittman, Timothy, Van Der Ende, Emma, Van Swieten, John C., Hartikainen, Päivi, Stojmenović, Gorana Mandić, Mehrabian, Shima, Ghidoni, Roberta, Alberici, Antonella C., Dell'Abate, Maria Teresa, Zecca, Chiara, Grassi, Mario, and Logroscino, Giancarlo

Published
2024
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165. Supplementary_material – Supplemental material for De-escalating rituximab dose results in stability of clinical, radiological, and serum neurofilament levels in multiple sclerosis

Author

Disanto, Giulio, Ripellino, Paolo, Riccitelli, Gianna C, Sacco, Rosaria, Scotti, Barbara, Fucili, Anita, Pravatà, Emanuele, Kuhle, Jens, Gobbi, Claudio, and Zecca, Chiara

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, Supplementary_material for De-escalating rituximab dose results in stability of clinical, radiological, and serum neurofilament levels in multiple sclerosis by Giulio Disanto, Paolo Ripellino, Gianna C Riccitelli, Rosaria Sacco, Barbara Scotti, Anita Fucili, Emanuele Pravatà, Jens Kuhle, Claudio Gobbi and Chiara Zecca in Multiple Sclerosis Journal

Published
2020
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166. Supplementary_table_1 – Supplemental material for Effectiveness of percutaneous posterior tibial nerve stimulation for the management of bowel dysfunction in multiple sclerosis patients

Author

Sacco, Rosaria, Braga, Andrea, Disanto, Giulio, Digesu, Giuseppe Alessandro, Maino, Paolo, Koetsier, Eva, Caccia, Giorgio, Serati, Maurizio, Renard, Julien, Gobbi, Claudio, and Zecca, Chiara

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, Supplementary_table_1 for Effectiveness of percutaneous posterior tibial nerve stimulation for the management of bowel dysfunction in multiple sclerosis patients by Rosaria Sacco, Andrea Braga, Giulio Disanto, Giuseppe Alessandro Digesu, Paolo Maino, Eva Koetsier, Giorgio Caccia, Maurizio Serati, Julien Renard, Claudio Gobbi and Chiara Zecca in Multiple Sclerosis Journal

Published
2020
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167. Serum neurofilament light chain captures and predicts confirmed progression independent of relapses (PIRA) in multiple sclerosis

Author

Lorscheider, Johannes, Benkert, Pascal, Yaldizli, Özgür, Disanto, Giulio, Oechtering, Johanna, Wuerfel, Jens, Chan, Andrew, Achtnichts, Lutz, Findling, Oliver, Derfuss, Tobias, Kropshofer, Harald, Orleth, Annette, Barnicol, Bettina Fischer, Aeschbacher, Stefanie, Maceski, Aleksandra Maleska, Rey, Dimitri, Zadic, Sabrina, Müller, Christian, Waubant, Emmanuelle, Oksenberg, Jorge, Wellmann, Sven, Wiendl, Heinz, Kappos, Ludwig, Salmen, Anke, Hoepner, Robert, Lalive, Patrice, Pasquier, Renaud A Du, Pot, Caroline, Maggi, Pietro, Zecca, Chiara, Naegelin, Yvonne, Müller, Stefanie, Hrusovsky, Kevin, Berger, Klaus, Conen, David, Barakovic, Muhamed, Sinnecker, Tim, Gobbi, Claudio, Granziera, Cristina, Leppert, David, and Kuhle, Jens

Published
2020
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168. Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories

Author

Kaufmann, Marco, Salmen, Anke, Barin, Laura, Puhan, Milo A, Calabrese, Pasquale, Kamm, Christian Philipp, Gobbi, Claudio, Kuhle, Jens, Manjaly, Zina-Mary, Ajdacic-Gross, Vladeta, Schafroth, Sandra, Bottignole, Britta, Ammann, Sabin, Zecca, Chiara, D'Souza, Marcus, von Wyl, Viktor, University of Zurich, and Kaufmann, Marco

Subjects
2728 Neurology (clinical), 2808 Neurology, 11549 Institute of Implementation Science in Health Care, 610 Medicine & health, EDSS, Registries, Patient reported outcome, Self-report, Proxy measure, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 360 Social problems & social services
Abstract

Background Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories. Methods We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4–6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity. Results Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62–0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4–6.5 and ≥7, respectively. Conclusions Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies., Multiple Sclerosis and Related Disorders, 42, ISSN:2211-0356, ISSN:2211-0348

Published
2020
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169. MSJ940548_Supplementary_Table_1 – Supplemental material for Longitudinal cortical thinning progression differs across multiple sclerosis phenotypes and is clinically relevant: A multicentre study

Author

Cruz, Milagros Hidalgo De La, Valsasina, Paola, Gobbi, Claudio, Gallo, Antonio, Zecca, Chiara, Bisecco, Alvino, Tedeschi, Gioacchino, Filippi, Massimo, and Rocca, Maria A

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, MSJ940548_Supplementary_Table_1 for Longitudinal cortical thinning progression differs across multiple sclerosis phenotypes and is clinically relevant: A multicentre study by Milagros Hidalgo de la Cruz, Paola Valsasina, Claudio Gobbi, Antonio Gallo, Chiara Zecca, Alvino Bisecco, Gioacchino Tedeschi, Massimo Filippi and Maria A Rocca in Multiple Sclerosis Journal

Published
2020
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171. Factors associated with employment and expected work retention among persons with multiple sclerosis: findings of a cross-sectional citizen science study

Author

Lehmann, Anja I; https://orcid.org/0000-0002-0108-4803, Rodgers, Stephanie, Kamm, Christian P, Mettler, Mathias, Steinemann, Nina, Ajdacic-Gross, Vladeta, Kaufmann, Marco, Kesselring, Jürg, Calabrese, Pasquale, Salmen, Anke, Gobbi, Claudio, Zecca, Chiara, Bauer, Georg F, von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797, Lehmann, Anja I; https://orcid.org/0000-0002-0108-4803, Rodgers, Stephanie, Kamm, Christian P, Mettler, Mathias, Steinemann, Nina, Ajdacic-Gross, Vladeta, Kaufmann, Marco, Kesselring, Jürg, Calabrese, Pasquale, Salmen, Anke, Gobbi, Claudio, Zecca, Chiara, Bauer, Georg F, and von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797

Abstract

Background: Multiple sclerosis (MS) notably affects adults of working age. For persons with MS (PwMS), being employed enhances their quality of life and it may be regarded as an indicator of overall functioning. Thus, ensuring work participation in PwMS is of general public health interest. Objective: To examine relevant socio-demographic, MS-, health- and work-related factors, including psychosocial working conditions, associated with currently working PwMS in Switzerland and their expected work retention. Methods: Using cross-sectional data of PwMS in the Swiss MS Registry (n = 541, median age = 48 [IQR 40;55]), multivariable logistic regression models were computed. First, currently working PwMS were characterised in comparison with those not currently working. Second, expected work retention, operationalized as subjective judgement "likely to work in the same job in 2 years", was examined within the group of currently working PwMS. Results: The factors age (OR 0.96, 95% CI 0.92-0.99), sex (OR 0.28, 95% CI 0.13-0.60), highest achieved job position (OR 1.21, 95% CI 1.01-1.46), health-related quality of life (HRQoL) (OR 1.02, 95% CI 1.01-1.04) and the number of MS symptoms (OR 0.90, 95% CI 0.82-0.98) were associated with currently working PwMS. Moreover, HRQoL (OR 1.07, 95% CI 1.04-1.10) and psychosocial working conditions, such as job resources (e.g. autonomy, control or social support) (OR 2.83, 95% CI 1.50-5.33) and job demands (e.g. workload, time pressure) (OR 0.41, 95% CI 0.18-0.90) were important factors for expected work retention among this group. Conclusions: Resourceful psychosocial working conditions are crucial for PwMS to maintain employment. Employers could contribute to work retention among PwMS by creating a work environment with resourceful psychosocial working conditions and providing, for instance, social support. Keywords: Cross-sectional study; Multiple sclerosis; Psychosocial work conditions; Workplace

Published
2020

172. Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories

Author

Kaufmann, Marco; https://orcid.org/0000-0002-4810-7734, Salmen, Anke, Barin, Laura, Puhan, Milo A; https://orcid.org/0000-0001-7284-1317, Calabrese, Pasquale, Kamm, Christian Philipp, Gobbi, Claudio, Kuhle, Jens, Manjaly, Zina-Mary, Ajdacic-Gross, Vladeta, Schafroth, Sandra, Bottignole, Britta, Ammann, Sabin, Zecca, Chiara, D'Souza, Marcus, von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797, Kaufmann, Marco; https://orcid.org/0000-0002-4810-7734, Salmen, Anke, Barin, Laura, Puhan, Milo A; https://orcid.org/0000-0001-7284-1317, Calabrese, Pasquale, Kamm, Christian Philipp, Gobbi, Claudio, Kuhle, Jens, Manjaly, Zina-Mary, Ajdacic-Gross, Vladeta, Schafroth, Sandra, Bottignole, Britta, Ammann, Sabin, Zecca, Chiara, D'Souza, Marcus, and von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797

Abstract

BACKGROUND: Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories. METHODS: We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4-6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity. RESULTS: Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4-6.5 and ≥7, respectively. CONCLUSIONS: Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.

Published
2020

174. Physiotherapy use and access-barriers in persons with multiple sclerosis: A cross-sectional analysis

Author

Fortunato, Remo, primary, van der Maas, Nico Arie, additional, Biland-Thommen, Ursula, additional, Kaufmann, Marco, additional, Sieber, Chloé, additional, Kamm, Christian P, additional, Zecca, Chiara, additional, Gobbi, Claudio, additional, Chan, Andrew, additional, Calabrese, Pasquale, additional, Kesselring, Jürg, additional, and von Wyl, Viktor, additional

Published
2021
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175. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Author

Dewan, Ramita, primary, Chia, Ruth, additional, Ding, Jinhui, additional, Hickman, Richard A., additional, Stein, Thor D., additional, Abramzon, Yevgeniya, additional, Ahmed, Sarah, additional, Sabir, Marya S., additional, Portley, Makayla K., additional, Tucci, Arianna, additional, Ibáñez, Kristina, additional, Shankaracharya, F.N.U., additional, Keagle, Pamela, additional, Rossi, Giacomina, additional, Caroppo, Paola, additional, Tagliavini, Fabrizio, additional, Waldo, Maria L., additional, Johansson, Per M., additional, Nilsson, Christer F., additional, Rowe, James B., additional, Benussi, Luisa, additional, Binetti, Giuliano, additional, Ghidoni, Roberta, additional, Jabbari, Edwin, additional, Viollet, Coralie, additional, Glass, Jonathan D., additional, Singleton, Andrew B., additional, Silani, Vincenzo, additional, Ross, Owen A., additional, Ryten, Mina, additional, Torkamani, Ali, additional, Tanaka, Toshiko, additional, Ferrucci, Luigi, additional, Resnick, Susan M., additional, Pickering-Brown, Stuart, additional, Brady, Christopher B., additional, Kowal, Neil, additional, Hardy, John A., additional, Van Deerlin, Vivianna, additional, Vonsattel, Jean Paul, additional, Harms, Matthew B., additional, Morris, Huw R., additional, Ferrari, Raffaele, additional, Landers, John E., additional, Chiò, Adriano, additional, Gibbs, J. Raphael, additional, Dalgard, Clifton L., additional, Scholz, Sonja W., additional, Traynor, Bryan J., additional, Adeleye, Adelani, additional, Alba, Camille, additional, Bacikova, Dagmar, additional, Hupalo, Daniel N., additional, Martinez, Elisa McGrath, additional, Pollard, Harvey B., additional, Sukumar, Gauthaman, additional, Soltis, Anthony R., additional, Tuck, Meila, additional, Zhang, Xijun, additional, Wilkerson, Matthew D., additional, Smith, Bradley N., additional, Ticozzi, Nicola, additional, Fallini, Claudia, additional, Gkazi, Athina Soragia, additional, Topp, Simon D., additional, Kost, Jason, additional, Scotter, Emma L., additional, Kenna, Kevin P., additional, Miller, Jack W., additional, Tiloca, Cinzia, additional, Vance, Caroline, additional, Danielson, Eric W., additional, Troakes, Claire, additional, Colombrita, Claudia, additional, Al-Sarraj, Safa, additional, Lewis, Elizabeth A., additional, King, Andrew, additional, Calini, Daniela, additional, Pensato, Viviana, additional, Castellotti, Barbara, additional, de Belleroche, Jacqueline, additional, Baas, Frank, additional, ten Asbroek, Anneloor L.M.A., additional, Sapp, Peter C., additional, McKenna-Yasek, Diane, additional, McLaughlin, Russell L., additional, Polak, Meraida, additional, Asress, Seneshaw, additional, Esteban-Pérez, Jesús, additional, Muñoz-Blanco, José Luis, additional, Stevic, Zorica, additional, D’Alfonso, Sandra, additional, Mazzini, Letizia, additional, Comi, Giacomo P., additional, Del Bo, Roberto, additional, Ceroni, Mauro, additional, Gagliardi, Stella, additional, Querin, Giorgia, additional, Bertolin, Cinzia, additional, van Rheenen, Wouter, additional, Diekstra, Frank P., additional, Rademakers, Rosa, additional, van Blitterswijk, Marka, additional, Boylan, Kevin B., additional, Lauria, Giuseppe, additional, Duga, Stefano, additional, Corti, Stefania, additional, Cereda, Cristina, additional, Corrado, Lucia, additional, Sorarù, Gianni, additional, Williams, Kelly L., additional, Nicholson, Garth A., additional, Blair, Ian P., additional, Leblond-Manry, Claire, additional, Rouleau, Guy A., additional, Hardiman, Orla, additional, Morrison, Karen E., additional, Veldink, Jan H., additional, van den Berg, Leonard H., additional, Al-Chalabi, Ammar, additional, Pall, Hardev, additional, Shaw, Pamela J., additional, Turner, Martin R., additional, Talbot, Kevin, additional, Taroni, Franco, additional, García-Redondo, Alberto, additional, Wu, Zheyang, additional, Gellera, Cinzia, additional, Ratti, Antonia, additional, Brown, Robert H., additional, Shaw, Christopher E., additional, Ambrose, John C., additional, Arumugam, Prabhu, additional, Baple, Emma L., additional, Bleda, Marta, additional, Boardman-Pretty, Freya, additional, Boissiere, Jeanne M., additional, Boustred, Christopher R., additional, Brittain, H., additional, Caulfield, Mark J., additional, Chan, Georgia C., additional, Craig, Clare E.H., additional, Daugherty, Louise C., additional, de Burca, Anna, additional, Devereau, Andrew, additional, Elgar, Greg, additional, Foulger, Rebecca E., additional, Fowler, Tom, additional, Furió-Tarí, Pedro, additional, Hackett, Joanne M., additional, Halai, Dina, additional, Hamblin, Angela, additional, Henderson, Shirley, additional, Holman, James E., additional, Hubbard, Tim J.P., additional, Jackson, Rob, additional, Jones, Louise J., additional, Kasperaviciute, Dalia, additional, Kayikci, Melis, additional, Lahnstein, Lea, additional, Lawson, Kay, additional, Leigh, Sarah E.A., additional, Leong, Ivonne U.S., additional, Lopez, Javier F., additional, Maleady-Crowe, Fiona, additional, Mason, Joanne, additional, McDonagh, Ellen M., additional, Moutsianas, Loukas, additional, Mueller, Michael, additional, Murugaesu, Nirupa, additional, Need, Anna C., additional, Odhams, Chris A., additional, Patch, Christine, additional, Perez-Gil, Daniel, additional, Polychronopoulos, Dimitris, additional, Pullinger, John, additional, Rahim, Tahrima, additional, Rendon, Augusto, additional, Riesgo-Ferreiro, Pablo, additional, Rogers, Tim, additional, Savage, Kevin, additional, Sawant, Kushmita, additional, Scott, Richard H., additional, Siddiq, Afshan, additional, Sieghart, Alexander, additional, Smedley, Damian, additional, Smith, Katherine R., additional, Sosinsky, Alona, additional, Spooner, William, additional, Stevens, Helen E., additional, Stuckey, Alexander, additional, Sultana, Razvan, additional, Thomas, Ellen R.A., additional, Thompson, Simon R., additional, Tregidgo, Carolyn, additional, Walsh, Emma, additional, Watters, Sarah A., additional, Welland, Matthew J., additional, Williams, Eleanor, additional, Witkowska, Katarzyna, additional, Wood, Suzanne M., additional, Zarowiecki, Magdalena, additional, Arepalli, Sampath, additional, Auluck, Pavan, additional, Baloh, Robert H., additional, Bowser, Robert, additional, Brice, Alexis, additional, Broach, James, additional, Camu, William, additional, Cooper-Knock, John, additional, Corcia, Philippe, additional, Drepper, Carsten, additional, Drory, Vivian E., additional, Dunckley, Travis L., additional, Faghri, Faraz, additional, Farren, Jennifer, additional, Feldman, Eva, additional, Floeter, Mary Kay, additional, Fratta, Pietro, additional, Gerhard, Glenn, additional, Gibson, Summer B., additional, Goutman, Stephen A., additional, Heiman-Patterson, Terry D., additional, Hernandez, Dena G., additional, Hoover, Ben, additional, Jansson, Lilja, additional, Kamel, Freya, additional, Kirby, Janine, additional, Kowall, Neil W., additional, Laaksovirta, Hannu, additional, Landi, Francesco, additional, Le Ber, Isabelle, additional, Lumbroso, Serge, additional, MacGowan, Daniel JL., additional, Maragakis, Nicholas J., additional, Mora, Gabriele, additional, Mouzat, Kevin, additional, Myllykangas, Liisa, additional, Nalls, Mike A., additional, Orrell, Richard W., additional, Ostrow, Lyle W., additional, Pamphlett, Roger, additional, Pioro, Erik, additional, Pulst, Stefan M., additional, Ravits, John M., additional, Renton, Alan E., additional, Robberecht, Wim, additional, Robey, Ian, additional, Rogaeva, Ekaterina, additional, Rothstein, Jeffrey D., additional, Sendtner, Michael, additional, Sidle, Katie C., additional, Simmons, Zachary, additional, Stone, David J., additional, Tienari, Pentti J., additional, Trojanowski, John Q., additional, Troncoso, Juan C., additional, Valori, Miko, additional, Van Damme, Philip, additional, Van Den Bosch, Ludo, additional, Zinman, Lorne, additional, Albani, Diego, additional, Borroni, Barbara, additional, Padovani, Alessandro, additional, Bruni, Amalia, additional, Clarimon, Jordi, additional, Dols-Icardo, Oriol, additional, Illán-Gala, Ignacio, additional, Lleó, Alberto, additional, Danek, Adrian, additional, Galimberti, Daniela, additional, Scarpini, Elio, additional, Serpente, Maria, additional, Graff, Caroline, additional, Chiang, Huei-Hsin, additional, Khoshnood, Behzad, additional, Öijerstedt, Linn, additional, Morris, Christopher M., additional, Nacmias, Benedetta, additional, Sorbi, Sandro, additional, Nielsen, Jorgen E., additional, Hjermind, Lynne E., additional, Novelli, Valeria, additional, Puca, Annibale A., additional, Pastor, Pau, additional, Alvarez, Ignacio, additional, Diez-Fairen, Monica, additional, Aguilar, Miquel, additional, Perneczky, Robert, additional, Diehl-Schimd, Janine, additional, Rossi, Mina, additional, Ruiz, Agustin, additional, Boada, Mercè, additional, Hernández, Isabel, additional, Moreno-Grau, Sonia, additional, Schlachetzki, Johannes C., additional, Aarsland, Dag, additional, Albert, Marilyn S., additional, Attems, Johannes, additional, Barrett, Matthew J., additional, Beach, Thomas G., additional, Bekris, Lynn M., additional, Bennett, David A., additional, Besser, Lilah M., additional, Bigio, Eileen H., additional, Black, Sandra E., additional, Boeve, Bradley F., additional, Bohannan, Ryan C., additional, Brett, Francesca, additional, Brunetti, Maura, additional, Caraway, Chad A., additional, Palma, Jose-Alberto, additional, Calvo, Andrea, additional, Canosa, Antonio, additional, Dickson, Dennis, additional, Duyckaerts, Charles, additional, Faber, Kelley, additional, Ferman, Tanis, additional, Flanagan, Margaret E., additional, Floris, Gianluca, additional, Foroud, Tatiana M., additional, Fortea, Juan, additional, Gan-Or, Ziv, additional, Gentleman, Steve, additional, Ghetti, Bernardino, additional, Gibbs, Jesse Raphael, additional, Goate, Alison, additional, Goldstein, David, additional, González-Aramburu, Isabel, additional, Graff-Radford, Neill R., additional, Hodges, Angela K., additional, Hu, Heng-Chen, additional, Hupalo, Daniel, additional, Infante, Jon, additional, Iranzo, Alex, additional, Kaiser, Scott M., additional, Kaufmann, Horacio, additional, Keith, Julia, additional, Kim, Ronald C., additional, Klein, Gregory, additional, Krüger, Rejko, additional, Kukull, Walter, additional, Kuzma, Amanda, additional, Lage, Carmen, additional, Lesage, Suzanne, additional, Leverenz, James B., additional, Logroscino, Giancarlo, additional, Lopez, Grisel, additional, Love, Seth, additional, Mao, Qinwen, additional, Marti, Maria Jose, additional, Martinez-McGrath, Elisa, additional, Masellis, Mario, additional, Masliah, Eliezer, additional, May, Patrick, additional, McKeith, Ian, additional, Mesulam, Marek-Marsel, additional, Monuki, Edwin S., additional, Newell, Kathy L., additional, Norcliffe-Kaufmann, Lucy, additional, Palmer, Laura, additional, Perkins, Matthew, additional, Pletnikova, Olga, additional, Molina-Porcel, Laura, additional, Reynolds, Regina H., additional, Rodríguez-Rodríguez, Eloy, additional, Rohrer, Jonathan D., additional, Sanchez-Juan, Pascual, additional, Scherzer, Clemens R., additional, Serrano, Geidy E., additional, Shakkottai, Vikram, additional, Sidransky, Ellen, additional, Tayebi, Nahid, additional, Thomas, Alan J., additional, Tilley, Bension S., additional, Walton, Ronald L., additional, Woltjer, Randy, additional, Wszolek, Zbigniew K., additional, Xiromerisiou, Georgia, additional, Zecca, Chiara, additional, Phatnani, Hemali, additional, Kwan, Justin, additional, Sareen, Dhruv, additional, Broach, James R., additional, Arcila-Londono, Ximena, additional, Lee, Edward B., additional, Shneider, Neil A., additional, Fraenkel, Ernest, additional, Zaitlen, Noah, additional, Berry, James D., additional, Malaspina, Andrea, additional, Cox, Gregory A., additional, Thompson, Leslie M., additional, Finkbeiner, Steve, additional, Dardiotis, Efthimios, additional, Miller, Timothy M., additional, Chandran, Siddharthan, additional, Pal, Suvankar, additional, Hornstein, Eran, additional, MacGowan, Daniel J., additional, Heiman-Patterson, Terry, additional, Hammell, Molly G., additional, Patsopoulos, Nikolaos.A., additional, Butovsky, Oleg, additional, Dubnau, Joshua, additional, Nath, Avindra, additional, Harms, Matt, additional, Aronica, Eleonora, additional, Poss, Mary, additional, Phillips-Cremins, Jennifer, additional, Crary, John, additional, Atassi, Nazem, additional, Lange, Dale J., additional, Adams, Darius J., additional, Stefanis, Leonidas, additional, Gotkine, Marc, additional, Babu, Suma, additional, Raj, Towfique, additional, Paganoni, Sabrina, additional, Shalem, Ophir, additional, Smith, Colin, additional, Zhang, Bin, additional, Harris, Brent, additional, Broce, Iris, additional, Drory, Vivian, additional, Ravits, John, additional, McMillan, Corey, additional, Menon, Vilas, additional, Wu, Lani, additional, Altschuler, Steven, additional, Amar, Khaled, additional, Archibald, Neil, additional, Bandmann, Oliver, additional, Capps, Erica, additional, Church, Alistair, additional, Coebergh, Jan, additional, Costantini, Alyssa, additional, Critchley, Peter, additional, Ghosh, Boyd CP., additional, Hu, Michele T.M., additional, Kobylecki, Christopher, additional, Leigh, P. Nigel, additional, Mann, Carl, additional, Massey, Luke A., additional, Nath, Uma, additional, Pavese, Nicola, additional, Paviour, Dominic, additional, Sharma, Jagdish, additional, and Vaughan, Jenny, additional

Published
2021
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179. Characterizing 1-year development of cervical cord atrophy across different MS phenotypes: A voxel-wise, multicentre analysis.

Author

Valsasina, Paola, Gobbi, Claudio, Zecca, Chiara, Rovira, Alex, Sastre-Garriga, Jaume, Kearney, Hugh, Yiannakas, Marios, Matthews, Lucy, Palace, Jacqueline, Gallo, Antonio, Bisecco, Alvino, Gass, Achim, Eisele, Philipp, Filippi, Massimo, Rocca, Maria A, Barkhof, Frederik, Ciccarelli, Olga, De Stefano, Nicola, Enzinger, Christian, and Gasperini, Claudio

Subjects
CERVICAL cord, ATROPHY, SPATIOTEMPORAL processes, SPINAL cord, MULTIPLE sclerosis
Abstract

Background: Spatio-temporal evolution of cord atrophy in multiple sclerosis (MS) has not been investigated yet. Objective: To evaluate voxel-wise distribution and 1-year changes of cervical cord atrophy in a multicentre MS cohort. Methods: Baseline and 1-year 3D T1-weighted cervical cord scans and clinical evaluations of 54 healthy controls (HC) and 113 MS patients (14 clinically isolated syndromes (CIS), 77 relapsing-remitting (RR), 22 progressive (P)) were used to investigate voxel-wise cord volume loss in patients versus HC, 1-year volume changes and clinical correlations (SPM12). Results: MS patients exhibited baseline cord atrophy versus HC at anterior and posterior/lateral C1/C2 and C4–C6 (p < 0.05, corrected). While CIS patients showed baseline volume increase at C4 versus HC (p < 0.001, uncorrected), RRMS exhibited posterior/lateral C1/C2 atrophy versus CIS, and PMS showed widespread cord atrophy versus RRMS (p < 0.05, corrected). At 1 year, 13 patients had clinically worsened. Cord atrophy progressed in MS, driven by RRMS, at posterior/lateral C2 and C3–C6 (p < 0.05, corrected). CIS patients showed no volume changes, while PMS showed circumscribed atrophy progression. Baseline cord atrophy at posterior/lateral C1/C2 and C3–C6 correlated with concomitant and 1-year disability (r = −0.40/–0.62, p < 0.05, corrected). Conclusions: Voxel-wise analysis characterized spinal cord neurodegeneration over 1 year across MS phenotypes and helped to explain baseline and 1-year disability. [ABSTRACT FROM AUTHOR]

Published
2022
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180. Differential association of cortical, subcortical and spinal cord damage with multiple sclerosis disability milestones: A multiparametric MRI study.

Author

Hidalgo de la Cruz, Milagros, Valsasina, Paola, Meani, Alessandro, Gallo, Antonio, Gobbi, Claudio, Bisecco, Alvino, Tedeschi, Gioacchino, Zecca, Chiara, Rocca, Maria A, and Filippi, Massimo

Subjects
DISABILITIES, SPINAL cord, MULTIPLE sclerosis, CERVICAL cord, CEREBRAL atrophy
Abstract

Background: In multiple sclerosis (MS), cortical, subcortical and infratentorial structural damage may have a differential contribution to clinical disability according to disease phases. Purpose: To determine the relative contributions of cortical, deep (D) grey matter (GM), cerebellar and cervical cord damage to MS disability milestones. Methods: Multi-centre 3T brain and cervical cord T2- and three-dimensional (3D) T1-weighted images were acquired from 198 MS patients (139 relapsing-remitting (RR) MS, 59 progressive (P) MS) and 67 healthy controls. Brain/cord lesion burden, cortical thickness (CTh), DGM and cerebellar volumetry and cord cross-sectional area (CSA) were quantified. Random forest analyses identified predictors of expanded disability status scale (EDSS) disability milestones (EDSS = 3.0, 4.0 and 6.0). Results: MS patients had widespread atrophy in all investigated compartments versus controls (p -range: ⩽0.001–0.05). Informative determinants of EDSS = 3.0 were cord CSA, brain lesion volume, frontal CTh and thalamic and cerebellar atrophy (out-of-bag (OOB) accuracy = 0.84, p -range: ⩽0.001–0.05). EDSS = 4.0 was mainly predicted by cerebellar and cord atrophy, frontal and sensorimotor CTh and cord lesion number (OOB accuracy = 0.84, p -range: ⩽0.001–0.04). Cervical cord CSA (p = 0.001) and cord lesion number (p = 0.003) predicted EDSS = 6.0 (OOB accuracy = 0.77). Conclusion: Brain lesion burden, cortical and thalamic atrophy were the main determinants of EDSS = 3.0 and 4.0, while cord damage played a major contribution to EDSS = 6.0. [ABSTRACT FROM AUTHOR]

Published
2022
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183. Plasma Inflammatory Cytokines Are Elevated in ALS

Author

Tortelli, Rosanna, primary, Zecca, Chiara, additional, Piccininni, Marco, additional, Benmahamed, Sara, additional, Dell'Abate, Maria Teresa, additional, Barulli, Maria Rosaria, additional, Capozzo, Rosa, additional, Battista, Petronilla, additional, and Logroscino, Giancarlo, additional

Published
2020
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184. Effectiveness of percutaneous posterior tibial nerve stimulation for the management of bowel dysfunction in multiple sclerosis patients

Author

Sacco, Rosaria, primary, Braga, Andrea, additional, Disanto, Giulio, additional, Digesu, Giuseppe Alessandro, additional, Maino, Paolo, additional, Koetsier, Eva, additional, Caccia, Giorgio, additional, Serati, Maurizio, additional, Renard, Julien, additional, Gobbi, Claudio, additional, and Zecca, Chiara, additional

Published
2020
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194. Patterns of Grey Matter Atrophy in Patients with MS: A Multivariate Analysis Using Source-based Morphometry (1481)

Author

Rocca, Maria A., primary, Valsasina, Paola, additional, Meani, Alessandro, additional, Gobbi, Claudio, additional, Zecca, Chiara, additional, Rovira, Alex, additional, Montalban, Xavier, additional, Kearney, Hugh, additional, Ciccarelli, Olga, additional, Matthews, Lucy, additional, Palace, Jacqueline, additional, Gallo, Antonio, additional, Bisecco, Alvino, additional, Lukas, Carsten, additional, Bellenberg, Barbara, additional, Barkhof, Frederik, additional, Vrenken, Hugo, additional, Preziosa, Paolo, additional, and Filippi, Massimo, additional

Published
2020
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196. Neurologic complications of acute hepatitis E virus infection

Author

Ripellino, Paolo, primary, Pasi, Emanuela, additional, Melli, Giorgia, additional, Staedler, Claudio, additional, Fraga, Monserrat, additional, Moradpour, Darius, additional, Sahli, Roland, additional, Aubert, Vincent, additional, Martinetti, Gladys, additional, Bihl, Florian, additional, Bernasconi, Enos, additional, Terziroli Beretta-Piccoli, Benedetta, additional, Cerny, Andreas, additional, Dalton, Harry Roland, additional, Zehnder, Cinzia, additional, Mathis, Barbara, additional, Zecca, Chiara, additional, Disanto, Giulio, additional, Kaelin-Lang, Alain, additional, and Gobbi, Claudio, additional

Published
2019
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198. Clinical, Molecular, and Protein Correlations in a Large Sample of Genetically Diagnosed Italian Limb Girdle Muscular Dystrophy Patients

Author

Guglieri, Michela, Magri, Francesca, DʼAngelo, Maria Grazia, Prelle, Alessandro, Morandi, Lucia, Rodolico, Carmelo, Cagliani, Rachele, Mora, Marina, Fortunato, Francesco, Bordoni, Andreina, Del Bo, Roberto, Ghezzi, Serena, Pagliarani, Serena, Lucchiari, Sabrina, Salani, Sabrina, Zecca, Chiara, Lamperti, Costanza, Ronchi, Dario, Aguennouz, Mohammed, Ciscato, Patrizia, Di Blasi, Claudia, Ruggieri, Alessandra, Moroni, Isabella, Turconi, Anna, Toscano, Antonio, Moggio, Maurizio, Bresolin, Nereo, and Comi, Giacomo P.

Published
2008
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199. Early pathological gambling in co-occurrence with semantic variant primary progressive aphasia: a case report

Author

Battista,Petronilla, Capozzo,Rosa, Rizzo,Giovanni, Zecca,Chiara, Anastasia,Antonio, De Blasi,Roberto, and Logroscino,Giancarlo

Subjects
Clinical Interventions in Aging
Abstract

Petronilla Battista,1,2 Rosa Capozzo,2 Giovanni Rizzo,3,4 Chiara Zecca,2 Antonio Anastasia,5 Roberto De Blasi,6 Giancarlo Logroscino2,71Istituti Clinici Scientifici Maugeri-SPA SB. I.R.C.C.S. Institute of Cassano Murge, Bari, Italy; 2Neurodegenerative Disease Unit, Department of Clinical Research in Neurology, University of Bari Aldo Moro, “Pia Fondazione Cardinale G. Panico”, Tricase, Italy; 3UOC Clinica Neurologica, IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy; 4Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; 5Department of Nuclear Medicine, Pia Fondazione di Culto e Religione “Card.G.Panico”, Tricase, Italy; 6Department of Diagnostic Imaging, Pia Fondazione di Culto e Religione “Card.G.Panico”, Tricase, Italy; 7Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, ItalyAbstract: We have comprehensively documented a case of semantic variant of primary progressive aphasia (sv-PPA) presenting with early-onset pathological gambling (PG). While a growing number of studies have shown the presence of behavioral alterations in patients with sv-PPA, PG has been observed only in the behavioral variant of frontotemporal dementia (bv-FTD). To date, no case of PG with the co-occurrence of prominent semantic deficits at the onset of the disease has been reported in the literature. Impulse disorders at onset may wrongly lead to a misdiagnosis (ie, psychiatric disorders). Therefore, a wider characterization of cognitive/aphasia symptoms in patients presenting impulse disorders and predominant language dysfunctions is recommended.Keywords: impulse disorders, language disorders, neurodegenerative diseases, semantic dementia

Published
2019

200. MSJ865989__STROBE_checklist – Supplemental material for Influence of CNS T2-focal lesions on cervical cord atrophy and disability in multiple sclerosis

Author

Pravatà, Emanuele, Valsasina, Paola, Gobbi, Claudio, Zecca, Chiara, Riccitelli, Gianna C, Filippi, Massimo, and Rocca, Maria A

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, MSJ865989__STROBE_checklist for Influence of CNS T2-focal lesions on cervical cord atrophy and disability in multiple sclerosis by Emanuele Pravatà, Paola Valsasina, Claudio Gobbi, Chiara Zecca, Gianna C Riccitelli, Massimo Filippi and Maria A Rocca in Multiple Sclerosis Journal

Published
2019
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