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The electrochemical reduction of CO2 into value-added chemicals has been explored as a promising solution to realize carbon neutrality and inhibit global warming. This involves utilizing the electrochemical CO2 reduction reaction (CO2RR) to produce a variety of single-carbon (C1) and multi-carbon (C2+) products. Additionally, the electrolyte solution in the CO2RR system can be enriched with nitrogen sources (such as NO3−, NO2−, N2, or NO) to enable the synthesis of organonitrogen compounds via C–N coupling reactions. However, the electrochemical conversion of CO2 into valuable chemicals still faces challenges in terms of low product yield, poor faradaic efficiency (FE), and unclear understanding of the reaction mechanism. This review summarizes the promising strategies aimed at achieving selective production of diverse carbon-containing products, including CO, formate, hydrocarbons, alcohols, and organonitrogen compounds. These approaches involve the rational design of electrocatalysts and the construction of coupled electrocatalytic reaction systems. Moreover, this review presents the underlying reaction mechanisms, identifies the existing challenges, and highlights the prospects of the electrosynthesis processes. The aim is to offer valuable insights and guidance for future research on the electrocatalytic conversion of CO2 into carbon-containing products of enhanced value-added potential. [ABSTRACT FROM AUTHOR]

Management of postoperative pain is of vital importance for patients undergoing Video‐Assisted Thoracoscopic Surgery (VATS) for Pulmonary Carcinoma Resection. The study evaluates the impact of Paravertebral Nerve Blockade (PNB) in conjunction with general anaesthesia on postoperative pain relief, as compared with general anaesthesia alone. A retrospective analysis was carried out from May 2020 to May 2023, involving 100 patients with pathologically confirmed pulmonary carcinoma. The patients were divided into two groups: a control group that received general anaesthesia and an observation group that received a combination of general anaesthesia and PNB. The intensity of postoperative pain was assessed at various time intervals using the visual analogue scale (VAS), while the effectiveness of patient‐controlled analgesia was also evaluated. Additionally, the study examined the incidence rates of chronic pain in the postoperative period. Statistical analysis was performed using IBM SPSS version 27.0. Significant reductions in VAS scores for both resting and cough‐induced pain were observed in the observation group at 2 and 6 h post‐operation (p < 0.01). However, the difference diminished over time. The observation group had fewer patient‐controlled analgesia activations and required lower dosages of hydromorphone at both 24‐ and 48‐h post‐operation. The incidence of chronic pain was also significantly lower in the observation group (24.00%) compared with the control group (54.00%) (p < 0.01). PNB, when administered in combination with general anaesthesia, significantly reduces immediate postoperative pain and the requirement for additional analgesics in patients undergoing VATS for pulmonary carcinoma resection. The effect diminishes over time but has a lasting impact on reducing the incidence of chronic postoperative pain. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, which can involve multiple systems. Patients with RA may have a variety of comorbidities, including cardiovascular disease (CVD), lung cancer, lymphoma, infection, osteoporosis, fatigue, depression, colon cancer, breast cancer, prostate cancer, and Alzheimer's disease. Among these comorbidities, the incidence of CVD, lung cancer, lymphoma, infection, and osteoporosis is higher. CVD is a serious complication of RA. The risk of CVD and associated mortality rate in patients with RA is high, and the treatment rate is low. In addition to traditional risk factors, such as age, sex, blood pressure, and diabetes, RA is also associated with inflammation. Furthermore, therapeutic drugs for RA, including non-steroidal anti-inflammatory drugs, glucocorticoids, and disease-modifying anti-rheumatic drugs, have beneficial or harmful effects on cardiovascular events in patients with RA. This article discusses the effects of therapeutic drugs for RA on cardiovascular events.

Objective: Incompletely resected epithelial ovarian cancer represents a poor prognostic subset of patients. Novel treatment strategies are needed to improve outcomes for this population. We evaluated a treatment strategy combining platinum-based chemotherapy with pembrolizumab followed by pembrolizumab maintenance therapy in the first-line treatment after incomplete resection of epithelial ovarian cancer patients. Methods: This was a single-arm, non-randomized pilot study of carboplatin, taxane, and immune checkpoint inhibitor, pembrolizumab, followed by 12 months of maintenance pembrolizumab in patients with incompletely resected epithelial ovarian cancer (EOC). Results: A total of 29 patients were enrolled and evaluated for efficacy and safety. The best response to therapy was complete response in 16 (55%) patients, partial response in 9 (31%) patients, and 3 (10%) patients with progression of disease. The median progression-free survival (PFS) was 13.2 months. Grade 3 and 4 toxicities occurred in 20% of patients. In all, 7 patients discontinued therapy due to adverse events. Quality-of-life scores remained high during therapy. Response to therapy did not correlate with PD-L1 tumor expression. Conclusions: Combination platinum--taxane therapy with pembrolizumab did not increase median progression-free survival in this cohort of patients. Key message: EOC is an immunogenic disease, but immune checkpoint inhibitor therapy has yet to impact outcomes. The current study utilized pembrolizumab in combination with standard chemotherapy followed by a maintenance treatment strategy in incompletely resected EOC. Progression-free survival was not extended in this poor prognostic group with combined chemotherapy and immunotherapy. [ABSTRACT FROM AUTHOR]

BACKGROUND: Public education has profound effects on the management effectiveness of invasive alien species by shaping stakeholders' knowledge systems. However, our understanding of the association between social media and farmers' knowledge is lacking for the majority of invasive agricultural pests. In this study, we used the fall armyworm (FAW), Spodoptera frugiperda, one of the most invasive insects globally, as a case to test the hypothesis that social media has a significant association with farmers' knowledge of FAW. To address this, we developed a theoretical framework, conducted extensive household questionnaires in the China‐Myanmar‐Laos border region (China), and used quantitative descriptions and binary logistic regressions in statistical analyses. RESULTS: Our results showed that (1) farmers frequently reported using 12 social media applications on smartphones (SMASs), and obtained FAW‐relevant information from six of them, with high preferences for WeChat and TikTok, (2) farmers possessed a generally high level of knowledge of FAW which was significantly associated with their socio‐demographic profiles, and (3) FAW‐relevant information from SMASs was significantly associated with certain aspects of farmers' knowledge of FAW. CONCLUSIONS: We concluded that social media has a significant association with farmers' knowledge of FAW. We suggest that well‐designed and ‐conducted educational programs based on the use of SMASs could help improve the management of FAW, and the Department of Agricultural Extension could play an important and necessary role. Our findings provide insights into this novel educational approach for the management of serious invasive agricultural pests. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Millisecond pulsars can serve as effective probes to investigate the presence of intermediate-mass black holes (IMBHs) within Galactic globular clusters (GCs). Based on the standard structure models for GCs, we conduct simulations to analyse the distributions of pulsar accelerations within the central region of NGC 6517. By comparing the measured accelerations of pulsars obtained from their period derivatives |$\dot{P}$| to the simulated distribution profiles, we demonstrate that a central excess of dark mass is required to account for the measured accelerations. Our analysis, which relies on existing pulsar timing observations, is currently unable to differentiate between two possible scenarios: an IMBH precisely situated at the core of the cluster with mass |${\gtrsim} 9000^{+4000}_{-3000} \, {\rm M}_{\odot }$| or a central concentration of stellar-mass dark remnants with a comparable total mass. However, with additional acceleration measurements from a few more pulsars in the cluster, it will be possible to differentiate the source of the non-luminous matter. [ABSTRACT FROM AUTHOR]

In recent years, an increasing number of observational studies have revealed an association between gut microbiota composition and psoriasis patients. However, whether this association reflects a causal relationship remains unclear. This study aimed to identify the causal relationship between gut microbiota and psoriasis through relevant research. In order to determine whether gut microbiota and psoriasis are causally related, we conducted a Mendelian randomization analysis using summary statistics from genome‐wide association studies (GWAS). As the exposure factor, we used summary statistics data from a GWAS study conducted by the MiBioGen Consortium, including 18,340 individuals with whole‐genome gut microbiota composition, and data from the FinnGen GWAS study on psoriasis, including 9267 patients and 364,071 controls as the disease outcome. Two‐sample Mendelian randomization analysis was subsequently performed with inverse variance weighted, MR‐Egger and weighted median, while sensitivity analyses were conducted to address heterogeneity and horizontal pleiotropy. The IVW results confirmed the causal relationship between certain gut microbiota groups and psoriasis. Specifically, family Veillonellaceae (OR = 1.162, 95% CI: 1.038–1.301, p = 0.009), genus Candidatus Soleaferrea (OR = 1.123, 95% CI: 1.011–1.247, p = 0.030) and genus Eubacterium fissicatena group (OR = 0.831, 95% CI: 0.755–0.915, p = 0.00016) showed significant associations. Sensitivity analysis did not reveal any abnormalities in SNPs. Currently, we have found some causal relationship between the gut microbiota and psoriasis. However, the study needs further RCTs for further validation. [ABSTRACT FROM AUTHOR]

Objective: To investigate whether primary Sjögren's syndrome (pSS) patients with hyperglobulinemia have an increased risk of all-cause mortality. Methods: Patients who registered in the Chinese Rheumatism Data Centre from May 2016 to July 2021 and met the 2002 American European Consensus Group criteria or 2016 American College of Rheumatology /European League Against Rheumatism classification criteria for Sjögren's syndrome were included. Hyperglobulinemia was defined as any elevated serum levels of immunoglobulin G (IgG), immunoglobulin A (IgA), or immunoglobulin M (IgM). The primary outcome was all-cause death. Data for demographic and clinical characteristics, laboratory results, disease activity, damage scores, and treatments were evaluated. Results: A total of 9527 pSS patients were included in the analysis, of whom 4236 (44.5%) had at least one kind of elevated immunoglobulin level among IgG, IgA, and IgM. Patients with hyperglobulinemia had a significantly increased risk of death (crude hazard ratio 2.60; 95% confidence interval 1.91–3.55; adjusted hazard ratio 1.90; 95% confidence interval 1.20–3.01). The risk of death was positively correlated with IgG level (P trend <.001). The 5-, 10-, and 15-year survival rates of patients with hyperglobulinemia were 96.9%, 92.3%, and 87.9%, respectively, and significantly lower than the corresponding rates of 98.8%, 97.9%, and 96.4% in patients without hyperglobulinemia. Conclusions: Hyperglobulinemia is an independent risk factor for increased all-cause mortality in pSS patients. The risk of death is positively correlated with IgG level. [ABSTRACT FROM AUTHOR]