151. PAX5 alteration-associated gene-expression signatures in B-cell acute lymphoblastic leukemia
- Author
-
Yuechao Zhao, Kuangguo Zhou, Wei Huang, Zhen Shang, and Yanling Xu
- Subjects
Male ,medicine.medical_specialty ,Ubiquitin-Protein Ligases ,Biology ,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ,hemic and lymphatic diseases ,Internal medicine ,Gene expression ,Ring finger ,medicine ,Cluster Analysis ,Humans ,Child ,Gene ,Genetics ,Regulation of gene expression ,Hematology ,Gene Expression Regulation, Leukemic ,Accession number (library science) ,Gene Expression Profiling ,PAX5 Transcription Factor ,Infant ,Gene expression profiling ,medicine.anatomical_structure ,Child, Preschool ,Cancer research ,Female ,PAX5 ,Carrier Proteins ,Transcriptome - Abstract
The paired box domain gene 5 (PAX5) is frequently altered in both childhood and adult B-cell acute lymphoblastic leukemia, and takes part in leukemogenesis. We analyzed data from the database of Gene Expression Omnibus (accession number: GSE11877) using bioinformatical and statistical methods. The results showed that cases of PAX5 alteration can cluster using unsupervised clustering algorithms, and one gene, zinc and ring finger 1 (ZNRF1), was characterized and validated by quantitative RT-PCR. ZNRF1 may be associated with leukemogenesis of ALL with PAX5 alteration.
- Published
- 2013