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Although continuous modalities of renal replacement therapy offer an advantage to the patient with compromised cerebral perfusion and intracranial hypertension, they are generally limited to the intensive care unit setting. Many hemodialysis patients admitted with strokes and subdural hematoma are managed on general wards. As such, these patients are generally treated by intermittent hemodialysis, and their dialysis prescription should be altered to minimize changes in serum osmolality, and fall in blood pressure during dialysis. Such patients require more frequent but shorter dialysis sessions, using minimally bioincompatible small surface area dialyzers with lower blood flows, in combination with higher sodium and cooled dialysate. In patients at risk of intracranial hemorrhage and those with invasive intracranial monitoring, systemic anticoagulants should be avoided, choosing no anticoagulation protocols or regional anticoagulants. [ABSTRACT FROM AUTHOR]

Objective : The surgical clipping of paraclinoid segment internal carotid artery aneurysms is considered difficult because of the complex anatomical location and important neighboring structures. Our experiences of pterional craniotomy and extradural anterior clinoidectomy (EAC) to clip paraclinoid aneurysms are reported herein. Methods : We present two patients with paraclinoid aneurysms who underwent surgical clipping using pterional craniotomy and EAC. The clinical results and operative techniques were reviewed from the patients' medical records. Results : EAC improves the surgical field in the suprasellar and periclinoid regions. Clinically, a good outcome was obtained in both cases. No surgical complications directly resulting from the EAC were observed. Conclusion : Favorable surgical results can be obtained with pterional craniotomy and EAC for the clipping of paraclinoid aneurysms. EAC is advocated for the clipping of paraclinoid aneurysms. [ABSTRACT FROM AUTHOR]

Abstract: We report a 66-year-old man with a spinal, extradural solitary fibrous tumor showing unique retiform and papillary architecture. The patient presented in May 2008 with worsening right-sided lower back pain and urinary frequency. Magnetic resonance imaging of the spine documented a heterogeneously enhancing dumbbell-shaped extradural lesion causing cord compression at T11/12 level. The tumor extended to the paravertebral soft tissue and invaded the right adjacent vertebral pedicles and laminae. An angiogram showed prominent vascular supply mainly from the right T11 radicular artery. The patient underwent surgery to relieve cord compression in May 2008 and a second operation following embolization with coils in October 2009. No recurrence was observed at the last neuroimaging follow-up in June 2012. The tumor was composed of vimentin, CD34, Bcl-2, and CD99-positive rounded or slightly elongated cells with scant cytoplasm and oval to spindle nuclei. Several pseudovascular spaces reminiscent of the rete testis were present, and several of them contained papillary projections. Cytologic atypia was minimal, and mitotic activity was low. Focal infiltration of the paraspinal adipose tissue was seen at microscopic level. To our knowledge, retiform and papillary features have never been reported in a solitary fibrous tumor. [Copyright &y& Elsevier]

Purpose: Primary spinal extradural Ewing's sarcoma (PSEES) or primitive neuroectodermal tumor (PNET) is uncommon. The present study summarizes the magnetic resonance (MR) imaging appearance of PSEES. Methods: Literature search from 1994 to 2012 with our representative case presentation. Results: Twenty-one patients, 12 males and 9 females, aged 3 weeks to 44 years, were identified. The thoracic spine was most frequently affected, followed by the cervical, cervicothoracic, and thoracolumbar spine. Superior-inferior extension of lesions was three vertebral levels in 7, two in 7, five in 4, four in 1, one in 1 and unknown in 1. PSEESs appeared isointense in 9 cases, hypointense in 2, hyperintense in 1, and no description in 9 on T1-weighted imaging, while hyperintense in 6, hypointense in 3, heterogeneous in 1, and no description in 11 on T2-weighted imaging. Varying enhancement was noted in 13 cases (62 %), with no description of contrast study in the other 8 cases. Dumbbell-shaped configuration of PSEES was found in 5 cases, foraminal widening in 4, and erosions or scalloping of the adjacent vertebral bodies in 4. Conclusion: The MR imaging appearance of PSEESs is indistinguishable from other tumors. PSEES should be assumed as the differential diagnosis of spinal extradural tumors in pediatric, adolescent, and young adult patients, and prompt surgical exploration should be performed. [ABSTRACT FROM AUTHOR]

Solitary spinal extradural plasmacytoma (SSEP) is a rare but distinct form of plasma cell disorder. The clinical picture and treatment of SSEP are reviewed using the seven previously reported cases. The three male and four female patients were aged 40-85 years. The location was cervical spine in one patient, cervicothoracic in one, thoracic in two, thoracolumbar in one, lumbar in one, and extensive involvement in one. Progressive paraparesis and sensory disturbance were the predominant symptoms. Neuroimaging showed a compressive extradural mass lesion in the dorsal spinal canal without findings of local bone destructive changes in all cases. Four of five patients who underwent decompressive surgical maneuver and tumor resection showed neurological improvement. Immunoglobulin (IgG) kappa subtype was the most predominant histological type, followed by IgD lambda and IgA kappa subtypes. SSEP should be included in the differential diagnosis of an extradural tumor located in the dorsal spinal canal without associated bony changes. Surgery may be effective for symptomatic relief. [ABSTRACT FROM AUTHOR]

Background: Spinal epidural arachnoid cysts (EAC) are rare and may present with myelopathy, which can be completely curable with surgery. The majority of investigators believe that the repairment of dural defect is important to treat EAC. However, the necessity of excising EACs remains controversial. The purpose of this study was to find a reasonable surgical technique for treatment of EACs after considering the clinical outcome, recurrence, and complications. Methods: The data from 44 operations in the literature and eight cases from our own experience were analyzed. This data included the surgical method, patient characteristics, level and size of the EAC, global assessment of the clinical outcomes, and the incidence of recurrence. Results: The recurrence rate was 2.0 % and 66.7 % in the patients who underwent repair of the dural defect and in those failed to repair of the dural defect, respectively ( p = 0.007). The recurrence rate was 8.3 % and 3.6 % in patients who underwent complete EAC excision totally, and those who underwent EAC fenestration only, respectively ( p = 0.590). The clinical outcome in patients with repaired dural defects was significantly better than that in patients with unrepaired dural defects (2.61 vs.1.67) ( p = 0.027). The clinical outcome score was 2.42 and 2.68 in patients who underwent complete EAC excision and those who underwent EAC fenestration only, respectively ( p = 0.158). The mean EAC length was 5.04 vertebral body levels (range, 2-13). Six of the 51 patients (11.7 %) had multiple EACs. Conclusions: Total excision of EACs may have little benefit in terms of cyst recurrence and clinical outcome. The procedure for EAC resection carries a risk of complications such as kyphosis. If EAC resection is performed, we suggest that a tailored short-level laminotomy be used to allow for the repair of dural defects. Particularly in patients with small EAC, a partial hemilaminectomy with dural defect repair may be a possible method to reduce complications. [ABSTRACT FROM AUTHOR]

Intraspinal extradural ganglion cysts rarely occur in the cervical spine, and their etiology is unknown. A 77-year-old female complaining of right upper extremity weakness presented with a cystic mass located in the spinal canal of the right C3-4 facet joint. A C3-4 right hemilaminectomy and excision of the cysts were performed. The cyst contained a translucent viscous material and was easily decompressed. No communication between the cyst and facet joints was found in the surgical field. The neurologic symptoms improved rapidly after surgery. The histology examination showed that the cystic wall was composed of dense fibrous tissue without a synovial cell lining concordant with a ganglion cyst. This report describes a rare case of a ganglion cyst of the cervical spine arising at the C3-4. This case highlights the need to consider a ganglion cyst as one of the causes of cervical radiculo-myelopathy. [ABSTRACT FROM AUTHOR]

Ewing's sarcoma is a rare tumor first discovered by James Ewing in 1921. It is more common in bone or skeletal component compared to soft tissue or extraosseous Ewing's sarcoma. Among soft tissue Ewing's, spinal cord involvement is rarer with only nine cases reported. We report a case of nine-year-old Malay girl who presented with low back pain for two months following a fall with progressive neurological deficits of bilateral lower limb. Magnetic resonance imaging was suggestive of a well-defined margin of intradural extramedullary tumor. With nerve sheath tumor in mind, surgical excision with laminectomy L2-S1 was performed. Intraoperative finding was an extradural mass from L3-L5 with extension to bilateral neuroforamen. Histopathology report defined a round cell tumour of Ewing's sarcoma from the mass. [ABSTRACT FROM AUTHOR]

Introduction: Destructive spondyloarthropathy may occur in long-term hemodialysis patients, but focal amyloid deposits in the spine are rare. We present a case of upper cervical extradural amyloidoma with a history of long-term hemodialysis presenting with progressive and intractable radiculopathy. Clinical presentation: We describe a 51-year-old female with a long-term history of hemodialysis treatment. She suffered progressive and intolerable right occipital headache. Neurological examination revealed right C2 radiculopathy. Magnetic resonance imaging (MRI) of the cervical spine showed a solid focal extradural mass lesion at the C2 level. She underwent subtotal resection of the extradural mass lesion and decompression of the right C2 nerve root by a posterior approach. Histological examination revealed amyloid deposits. The occipital headache immediately disappeared after surgery. Follow-up MRI 10 months after surgery demonstrated no recurrence of the extradural amyloidoma. Conclusion: Development of an upper cervical extradural amyloidoma after long-term hemodialysis is extremely rare. Prompt evaluation of long-term hemodialysis patients suffering from progressive cervical pain should be recommended, and treatment is required if there are signs or symptoms of compression of a nerve root or the spinal cord. [ABSTRACT FROM AUTHOR]

Objective: To demonstrate that anterior clinoidectomy is possible through the lateral supraorbital (LSO) approach, and that extent of the clinoidectomy is tailored according to the lesion. We reviewed our recent experience on patients with vascular and tumor who underwent anterior clinoidectomy through the LSO approach. Methods: Between June 2007 and January 2011, 82 patients with neoplastic and vascular lesions underwent anterior clinoidectomy by the senior author (J.H.) with the LSO approach. We retrospectively analyzed the surgical videos and the microsurgical techniques of anterior clinoidectomy. Results: Forty-five patients were treated for aneurysms, 35 patients for intraorbital, parasellar and suprasellar tumors, and 2 patients presented with carotid-cavernous fistula. Intradural anterior clinoidectomy was performed in 67 patients (82%); in 15 patients (18%) extradural anterior clinoidectomy was used. A minimal removal of the anterior clinoid process (ACP) was performed in 5 patients, in 8 patients a partial clinoidectomy was performed, in 18 patients a subtotal removal of the ACP was needed, and in 51 patients, the entire ACP was removed. There was no operation-related mortality in the series. Conclusions: A tailored anterior clinoidectomy is useful and can be performed through the LSO approach. Intradural visualization of the internal carotid artery and optic nerve is mandatory for the exact anatomic orientation and safe anterior clinoidectomy. We recommend intradural anterior clinoidectomy for all vascular and most neoplastic lesions. [ABSTRACT FROM AUTHOR]

Background: To investigate characteristic clinical and radiological features of extradural arachnoid cysts (EDACs) in the thoracolumbar region, a retrospective review of medical records and imaging studies was performed. EDACs are well known but relatively rare lesions in the thoracolumbar spinal canal. The most common site is the lower thoracic spine, and it may cause neurological symptoms by compressing the spinal cord or nerve root. In this study, the pathogenesis, symptomatology, diagnostic approach, and surgical management of EDACs will be discussed. Methods: We studied 14 consecutive patients who were surgically treated for EDACs in the thoracolumbar region at our institute between March 2000 and January 2011. The history, clinical presentations, image findings, operative findings, and surgical outcomes of these patients were retrospectively analyzed. The mean follow-up period was 28 months (range: 6-72 months). Results: Progressive motor weakness was the predominant symptom in all patients. Nine patients had radicular leg pain and back pain in the thoracolumbar area. On MRI, the cyst compressed the dural sac and spinal cord posteriorly typically with bilateral foraminal extensions. On radiological study, a communication point with the subarachnoid was hardly observed. The surgical treatment of EDACs included complete resection of the walls and closing the communicating point with the subarachnoid space. All patients showed excellent outcomes according to Odom's criteria without recurrence. One CSF leakage and one postoperative hematoma were noted. Conclusions: Thoracolumbar EDAC patients presented paraparesis and leg pain. Complete excision and closing the communicating point with the subarachnoid space were the choices of treatment, and the outcomes were favorable. [ABSTRACT FROM AUTHOR]

Facial nerve schwannoma (FNS) are rare tumors usually presenting as a cerebellopontine angle (CPA) mass. Rarely, FNS can present as significant mass in the middle cranial fossa. They are usually approached using intradural procedures; however, we decompressed the tumor through an extradural procedure and could decompress it significantly without any morbidity.A 15-year-old female presented with progressive right-sided facial weakness, followed by left-sided hearing loss since the last 1 year. She was evaluated and it was found that she had an FNS involving the posterior and middle cranial fossa, with a significant tumor in the middle cranial fossa.Extradural subtemporal combined with a transpetrosal approach was used for tumor decompression; some of the residual tumor in the left cerebellopontine cistern was managed by a postoperative gamma knife surgery to preserve the facial nerve functions.FNS can be one of the rare differential diagnoses of a tumor in the middle cranial fossa base and can be managed effectively by an extradural approach. [ABSTRACT FROM AUTHOR]

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Background: There have been 18 reported cases of primary spinal intradural, extramedullary ependymomas reported in the literature. One of the 18 cases had an extradural component and was benign. Our case is the second spinal intradural, extramedullary ependymoma with an extradural component and the first with its initial presentation as an anaplastic ependymoma. Case Description: A 50-year-old male presented with bilateral upper thigh weakness and thoracic numbness. His exam showed the pin-prick level at T5. Magnetic resonance imaging (MRI) of the thoracic spine showed an enhancing lesion at T5–6 with severe compression of the spinal cord with a dumbbell shape extension of the tumor through the right T5–6 neural foramen. The patient had a laminectomy at T4–T6 with the resection of the tumor. Postoperatively, the patient regained full strength in his lower extremities. Intraoperatively, the tumor was found to be intradural, extramedullary with an extradural component. The tumor was found to be an anaplastic ependymoma. Conclusions: Even though spinal intradural extramedullary ependymomas are very rare, surgeons must be aware that on MRI, they can be mistaken for meningiomas or nerve sheath tumors especially if there is an extradural component. Our case report is the first intradural, extramedullary ependymoma that is anaplastic and has an extradural component. A review of the literature provides little information on the treatment and prognosis for these tumors especially if they are anaplastic. We propose that the treatment, as done in our case, should be complete resection of the tumor with spinal radiotherapy to the tumor level. [ABSTRACT FROM AUTHOR]

Ewing's sarcoma / peripheral primitive neuroectodermal tumors occur most often in bone and soft tissues of children and young adults. The intracranial manifestation of the disease is rare, and when present, this is often misdiagnosed with other varieties of primary brain tumors. We report such a case of extraosseous Ewing's sarcoma, which was initially suspected to be a case of meningioma in an 11-year-old girl. [ABSTRACT FROM AUTHOR]

Von Ricklinghausen's disease is commonly associated with simultaneous cranial and spinal meningioma but these are not true meningiomas. Craniospinal meningiomas without Von Ricklinghausen's disease are very rare. We report a 13-year-old girl who presented with two episodes of right focal seizure with secondary generalisation of three year's duration, weakness of both lower limbs for 6 months, and retention of urine of three month's duration. MRI brain showed enhancing lesion in the left fronto-parietal region. MRI spine revealed enhancing intradural extramedullary lesion at D, D, and L. The tumours were excised completely in a single stage, first by craniotomy then by multi level laminectomy. On histology the spinal meningioma had predominant meningothiliomatous. We followed up for 6 months and the patient recovered with power grade 4/5 both lower limb. [ABSTRACT FROM AUTHOR]

Juvenile nasopharyngeal angiofibroma (JNA) are locally growing highly vascular tumours treated primarily by surgical excision (open approach as wide as a mid facial degloving or endoscopic approach). All our patients underwent exclusive endoscopic tumour excision after a pre-operative embolisation. The tumours were completely resected with acceptable blood loss and no recurrences or residual masses were seen. Post-operative morbidity was minimal without external scar-marks. To conclude endoscopic excision is a very effective method to resect JNA even for extensive tumours. [ABSTRACT FROM AUTHOR]

Satisfactory analgesia has been related with epidural 2 adrenoceptor agonists in combination with local anesthetics. The aim of this study was to compare the analgesic and cardiopulmonary effects of lidocaine or lidocaine-clonidine epidural injections in healthy dogs. Dogs were randomly assigned to two groups of six animals each. The L group received lidocaine (5mg kg-1 L) and the C group lidocaine plus clonidine (10μg kg-1 C). Preanaesthetic medication was carried out with acepromazine (0.05mg kg-1 IV). Anaesthesia was induced and maintained with isoflurane by facial mask for epidural injection. Heart rate (HH), electrocardiography (ECG), respiratory rate (RR), systolic arterial blood pressure (SAP), rectal temperature (RT), blood gases, duration of anesthesia and sensitive block level were investigated. Statistical analysis was performed with ANOVA, Tukey test and paired t test. There was a decrease of HR at 15, 30 and 45 minutes after epidural injection in C group when compared with L group. Cardiac dysrhythmias did not observe in both treatments. The variables, SAP, RR, RT and blood gases did not differ between treatments. Duration of anesthesia was 71±13 and 75±26 minutes to L and C treatment, respectively, without difference between groups. The maximal extension of sensitive block was the fourth lumbar vertebra and the tenth thoracic vertebra in L and C treatment, respectively. In conclusion, the addition of clonidine to lidocaine in epidural anesthesia allowed more cranial sensory block in relation to the isolated use of local anesthetic, however, it produced bradycardia and did not prolong the duration of anesthesia. [ABSTRACT FROM AUTHOR]

Hydatid disease is endemic in regions where livestock is raised. Liver and lungs are the most commonly affected organs by the disease. Cranial vault and orbital hydatid disease is extremely rare. Signs and symptoms along with serological investigation are often inconclusive in cranial hydatid, making radiological diagnosis extremely important. Surgical removal of the cyst is the mainstay of treatment. Postoperative medical therapy, along with regular follow-up, is the key to detect any recurrence. We report an unusual case of cranial hydatid which showed diffuse scalp infiltration along with oribital and extradural extension. [ABSTRACT FROM AUTHOR]

Primary spinal malignant melanoma is an extremely rare condition. We here describe a case of a 71-year-old Asian female presenting with left upper extremity tingling sensation. Computed tomography (CT) showed a homogeneously enhanced mass occupying the left neural foramen at the C6-7 level. Magnetic resonance imaging revealed enhanced mass in intra- and extradural space compressing the spinal cord at this level. It also widened the neural foramen mimicking neurofibroma or schwannoma. Partial resection of the mass was performed. Pathologic diagnosis of the mass was malignant melanoma. Postoperative whole body positron emission tomography/CT scan demonstrated an intense 18F-FDG uptake at the residual mass site without abnormal uptake at other sites in the body. [ABSTRACT FROM AUTHOR]

Tramadol is a synthetic opioid agonist used extensively in human and, to a lesser extent, veterinary medicine throughout the world. The clinical efficacy and pharmacokinetic profile of intravenous (IV) and extradural (ED) tramadol (2 mg/kg) and its o-desmethyl metabolite were studied in dogs undergoing tibial plateau levelling osteotomy (TPLO). Intra-operative cardiorespiratory variables were monitored and post-operative pain was assessed using the short form of the Glasgow Composite Pain Scale. A rapid (<5 min) and effective production of o-desmethyl tramadol was recorded. The pharmacokinetic profile was similar for tramadol and its metabolite irrespective of the route of administration. ED tramadol provided sufficient intra- and post-operative analgesia without significant clinical side-effects, but the postoperative analgesia was comparable to that following IV administration and the ED route could therefore not be considered a practical alternative to the IV route. [ABSTRACT FROM AUTHOR]

Two cases of extradural epidermoid cyst presented a symptom of headache. Computed tomography showed a high-density mass in one case without enhancement, and low-density mass in the other case with rim enhancing. Magnetic resonance imaging (MRI) revealed different signals imaging finding variation, depending on the contents of epidermoid cyst. The preoperative diagnoses of the cases are mistaken. At surgery, the lesions were found to be an epidermoid cyst. Typical MRI and computed tomography findings are neither specific for nor constant with epidemoid cysts. MRI, however, has not eliminated the need for a thoughtful, critical approach to differential diagnosis. [ABSTRACT FROM AUTHOR]

Objective To determine the usefulness of an acoustic device to confirm correct placement of extradural needles in horses. Study design Prospective experimental study. Animals Twelve adult healthy horses weighing between 434 and 640 kg. Materials and methods Horses were sedated, placed in stocks and subjected to caudal extradural anaesthesia using lidocaine 2%. For extradural puncture an 18 gauge Tuohy needle connected to an acoustic device via an electronic pressure transducer was used. This device allowed recording of the extradural pressure profile and the transformation of pressure changes into an audible signal. Extradural needle advancement was stopped and the local anaesthetic administered when either a sharp decrease in sound pitch occurred or a ‘pop’ sensation was felt. Correct needle placement was assessed clinically by the degree of extradural anaesthesia present using needle prick stimuli, loss of tail tone and occurrence of localized sweating. Descriptive statistical analysis was used for evaluation of the data. Results Extradural anaesthesia was successful in nine of 12 horses. In these horses during extradural needle advancement the pitch of the audible signal first increased and abruptly changed to a constant low pitched sound. In the three horses with unsuccessful punctures only a slight decrease of the pitch was noted. A ‘pop’ was clearly distinguished in five of nine horses with successful extradural puncture. In four horses a ‘pop’ was not present despite correct extradural needle placement. In three horses with incorrect needle placement a ‘pop’ was present. In the horses with correct needle positioning the median extradural pressure after the puncture was −0.8 kPa (−6 mmHg). Conclusion and clinical relevance The acoustic device is useful to assist in the identification of successful or unsuccessful extradural needle placement in the horse. [ABSTRACT FROM AUTHOR]

Meningiomas are benign in nature and arise from the arachnoid cells. They are mostly situated in the intracranial compartment, whereas spinal meningiomas are rare. Approximately, in 10% of cases, an extradural component is seen but an exclusively extradural meningioma is quite uncommon. However, WHO Grade II (atypical) and Grade III (anaplastic) tumors can behave aggressively. We reported a case of purely extradural psammomatous meningioma in an adult male affecting the dorsal spine although uncommon meningiomas should be included in the differential diagnosis of extradural intraspinal masses. [ABSTRACT FROM AUTHOR]

Extradural haematomas are a significant consequence of head injuries in children. The aim of this study was to evaluate the demographics, symptoms and signs, management and outcome of patients less than 18 years of age with extradural haematomas in our unit. We also specifically looked at repeat imaging performed, indications for this and its effect on further management. No previous reviews have included this. Fifty-six patients were identified from 01/01/1997 to 01/01/2007 for inclusion in this study. Their imaging was then reviewed as were the case notes. Of the patients studied, 70% were male. The average age was 10 years and 2 months with an average length of stay of one week. The commonest mechanisms of injury were a fall from height and an accident involving a bike. Presenting symptoms were documented in 40% of cases. 32% of patients had associated skull fractures. Six patients had other injuries, including long bone fractures and maxillofacial injuries . Glasgow Coma Scale was generally better on admission than pre-operatively and post-operatively was generally better than prior to surgery. Eight patients had neurological signs on admission, 11 had pre-operatively, and nine had post-operatively. 71% underwent a craniotomy with evacuation of the haematoma. Complications were reported in 16% with no mortality. 66% were seen in a neurosurgical clinic, with 46% seen in a Paediatric Head Injury Clinic after discharge. 66% had further imaging after their initial scan of which 52% had no clinical indication. Eight patients were operated on following re-imaging. Most extradural haematomas in children are caused by falls or vehicle accidents. The majority are treated surgically and do well. Indications for further scanning are often not present and in most, management is unchanged. The follow up of these patients also appears to be suboptimal. [ABSTRACT FROM AUTHOR]

Abstract: Background context: Removal of cervical dumbbell tumors can be particularly challenging because of unique exposure requirements and proximity of the vertebral artery (VA). There are no reports describing the treatment of giant cervical spine dumbbell tumors (CSDTs). Purpose: To introduce an extensive posterolateral approach to CSDTs involving total lateral mass resection and laminectomy. Study design: Prospective study of all the patients with multilevel CSDTs treated by this new procedure between December 2002 and March 2006. Patient sample: Sixteen patients (3 men and 13 women) with CSDTs underwent the procedure we describe. The follow-up periods ranged from 9 to 51 months (average 9 months). Average age at surgery was 45 years (range 23–68 years). Outcome measures: Axial symptoms and Japanese Orthopedic Association scores were recorded. Pre- and postoperative ranges of neck motion were measured on lateral flexion and extension radiographs. Methods: After making a midline incision, we preferred exposing the extraforaminal component of the tumor before performing a semilaminectomy and lateral mass resection. Any lateral extension of a tumor can be attained by detachment of the adjacent three or more segments of the lateral mass muscle insertion. The most lateral portion can be separated beneath the tumor''s superficial muscle flap, and then when the tumor is retracted medially, the whole portion of the lateral component can be totally exposed. We then performed total lateral mass resection and laminectomy to expose the tumor at the foramina and cervical canal. Results: We were able to completely resect the tumors in every patient. The average duration of surgery was 150 minutes. Blood loss was minimal (average 400 mL). All patients were monitored for a minimum of 9 months (range 9–51 months; mean 28 months). The follow-up period was uneventful, and no patients developed spinal instability. Conclusions: Extensive posterolateral exposure enables surgeons to reach the lateralmost portion of CSDTs and also facilitates septation of the VA and resection of vertebral body encroachment of the tumor. [Copyright &y& Elsevier]

Abstract: Despite being a well-understood pathology, patients with an extradural spinal abscess (ESA) still experience delays in diagnosis, with associated morbidity and mortality. This 10-year retrospective audit aimed to define the presentation, findings and prognosis of ESA in a New Zealand tertiary referral centre. Forty-two patients were diagnosed and treated between 1 May 1997 and 30 June 2007. The mean age was 55 years, with a male predominance of 1.6:1. Staphylococcus aureus was identified in 67% of patients. On presentation, 27/38 patients with back pain were afebrile and 2/37 patients had a normal C-reactive protein (CRP) level in the first 24 hours. Ten patients were discharged with neurological dysfunction and one died. One reason for the delays in diagnosis and appropriate referral could be the lack of “red flag” symptoms at the time of presentation. Attention needs to be paid to the history and nature of a patient’s back pain. We recommend routine CRP and full blood count to help raise clinical suspicion. [Copyright &y& Elsevier]

Recent advances in ultrasound (US) imaging have significantly improved our understanding of spinal sonoanatomy. Today, US imaging has been used to assist or guide central neuraxial blocks, and it appears to be a promising alternative to traditional landmark-based technique. US is noninvasive, safe, simple to use, can be quickly performed, does not involve exposure to radiation, provides real-time images, and is free from adverse effects. Currently, the majority of the outcome data are from its application in the lumbar region. A scout (prepuncture) scan allows the operator to preview the spinal anatomy, identify the midline, accurately predict the depth to the epidural space, and determine the optimal site and trajectory for needle insertion. When used for central neuraxial blocks, it also improves the success rate of epidural access on the first attempt, reduces the number of puncture attempts or the need to puncture multiple levels, and improves patient comfort during the procedure. Preliminary data suggest that US may also offer technical advantages in patients with abnormal spinal anatomy. It is also an excellent teaching tool and improves the learning curve of epidural blocks in parturients. However, the use of US for central neuraxial blocks is still in its infancy, and there is a need for more research in this state of the art regional anesthesia before it can become a standard of care. [Copyright &y& Elsevier]

Intracranial complications after cochlear implantation are rare. The authors present the case of a 13 month old boy with a contralateral abducens nerve palsy following cochlear implantation that led to the diagnosis of an extradural haematoma on computerised tomography scanning. The abducens palsy resolved after evacuation of the haematoma and the patient made an excellent recovery. The literature is reviewed and the mechanism of injury discussed. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Aggressive epidural intracranial lesions that break through the dura and develop an intra-axial component have been well-described previously in literature. However, there is no description of lesions with an epidural component and an exclusive subdural component without parenchymal extension in the pediatric patient. We have noticed a characteristic sign on cross-sectional imaging studies that indicates dural breakthrough resulting in a large extradural component and second subdural component, but no extraparenchymal component. This is best described as a “volcano sign” which characterizes the appearance caused by a focal break in the dural lining resulting in a sizeable subdural component from rapid lesion growth. In the pediatric patient, this sign is characteristic of a rapidly growing sarcomatous lesion, either primary or secondary. [ABSTRACT FROM AUTHOR]

The article describes the case of a pet domestic rabbit diagnosed with spinal lymphoma and concurrent pulmonary filariasis. The physical examination of the rabbit revealed adequate hydration. The pelvic limb examination revealed bilateral loss of motor control, proprioceptive deficits, and the absence of superficial and deep pain.

A 7-year-old castrated male Labrador retriever was referred for evaluation of progressive hind limb paresis of 4 weeks' duration. On computed tomography and magnetic resonance imaging examination, masses were found in several regions including the lung, right kidney, and peritoneum. Additionally, an extradural mass at the region of T13–L1 was identified, which is assumed to related to the chief complaint, progressive hind limb paresis. With the consent of the owner, a dorsal laminectomy was performed to remove the mass and surrounding tissues for the palliation of the hind limb paresis. Hematoxylin and eosin staining and immunohistochemical examination revealed the mass to be consistent with an undifferentiated (high-grade) pleomorphic sarcoma. The patient presented with recurrence of the hind limb paresis, respiratory discomfort, and urinary incontinence. The owner declined treatment and the dog was euthanized. Systemic metastasis was confirmed on postmortem microscopic examination. To the authors' knowledge, this is the first report describing multiple undifferentiated high-grade pleomorphic sarcoma with extradural involvement developing into the vertebral canal through the intervertebral space, resulting in spinal damage, in a dog. [ABSTRACT FROM AUTHOR]

Objective To evaluate and compare the effect of epidural bupivacaine on analgesia produced by epidural xylazine or medetomidine in buffaloes. Study design Prospective, blinded study. Animals Ten male buffalo calves (6–8 months of age; body weight 70–90 kg) were used on two occasions to conduct a total of 20 investigations. Methods Caudal extradural analgesia was produced in four buffalo calves each by the injection of either xylazine (0.05 mg kg−1), medetomidine (15 μg kg−1) or 0.5% bupivacaine (0.125 mg kg−1), or combinations of xylazine and bupivacaine (0.05 and 0.125 mg kg−1), or medetomidine and bupivacaine (15 μg kg−1 and 0.125 mg kg−1) at the first intercoccygeal extradural space. Analgesia was tested using deep pinprick stimuli. Results Extradural administration of xylazine or medetomidine resulted in complete analgesia of the tail, perineum, inguinal region and the upper parts of the hind limbs, which was faster in onset and longer in duration in the medetomidine group than in the xylazine group. Addition of bupivacaine increased the intensity of the analgesia produced by xylazine, but not that produced by medetomidine. All the drugs caused mild to moderate ataxia, but signs of sedation were apparent only in animals which received xylazine or medetomidine. The extradural injections of all the drugs caused significant decrease in heart rate ( p = 0.024), respiratory rate ( p = 0.026) and rectal temperature ( p = 0.036) from the respective baseline values, but the differences between the groups were not significant. Conclusions Medetomidine produced a longer duration of analgesia than that produced by xylazine. Bupivacaine prolonged the analgesia produced by xylazine, but the analgesia produced by the combination of medetomidine and bupivacaine was not superior to that produced by medetomidine alone. Clinical relevance Bupivacaine may be used to prolong the extradural analgesia produced by xylazine, but not that produced by medetomidine in buffaloes. [ABSTRACT FROM AUTHOR]

Abstract: Background context: Intraspinal primitive neuroectodermal tumors (PNETs) are an exceedingly rare entity. A recent literature research revealed 28 cases reported. Only a few tumors in the literature were extradural in location, in the cervical and thoracic spine. The average survival after combination treatment including chemotherapy, radiation, and surgical resection is 20 months for the cases reported in the literature. Purpose: We report a case of a patient with sciatica and cauda equine–like symptoms. Study design: Case report. Methods: Urgent sacral decompression and resection of the tumor was performed with rapid pain relief for the patient. Results: Histology revealed a sacral extradural small blue-cell tumor, consistent with ES/PNET family tumors. An oncological workup revealed that the tumor presentation was metastatic with pulmonary and abdominal nodules. The patient underwent combination chemotherapy with vincristine, doxorubicin, and cyclophosphamide with mesna for 4 months. Conclusions: The patient was without disease after excision, two courses of 4-month chemotherapy, and one course of 5-week radiation to the sacrum at 2 years. [Copyright &y& Elsevier]

Peridural anesthesia is broadly applied in the Veterinary field, using the isolated local anesthetic or in combination with opiates capable to increase the analgesic effect. This research compared analgesia and cardiorespiratory effects of epidural anaesthesia produced by ropivacaine alone or combined with fentanyl or tramadol in eight mixed breed adult dogs after sedation with acepromazina. Drugs were administered on the following protocols: GR (ropivacaine), GRF (ropivacaine + fentanyl), GRT (ropivacaine + tramadol), in 0.25ml kg-1 of total volume. Heart and respiratory rate, rectal temperature, blood pressure and, gasometry of atrial blood were mensured, as well the sensory and motor blockade (latency and period of action), degree of sedation and side effects. The most important decrease of the heart rate occurred in GRF and GRT. Also significant hypothermia in GRF. Intense degree of sedation was observed in GRF and GRT. The period of recovery was shorter in GRT. The most cranial region of blockade occurred in GRT. Bradicardia, hypothermia and Shiff- Sherrington syndrom were observed in the transanesthetic period in animal from all of the groups. During 24 hours after the anaesthesia no side effects were observed. The GRF had the longer period of anesthesia and analgesia, GRT presented the shorter period of anesthesia with intermediate analgesia and, GR presented intermediate period of anesthesia with lower degree of analgesia. Respiratory and hemogasometrics change were not found, but hipotermy, bradicardy and Schiff-Sherrington syndrome, side effects usually seen in peridural anesthesia, were observed in this study. [ABSTRACT FROM AUTHOR]

Unlabelled: We report a rare case of spinal extradural abscess presenting as Staphylococcus aureus meningitis in a previously well child. After initial improvement with intravenous antibiotics the patient clinically deteriorated in a non-specific manner. Magnetic resonance imaging (MRI) scan of the spine revealed an occult spinal extradural abscess and urgent neurosurgical laminectomy led to full recovery. No evidence of an underlying spinal abnormality or immunodeficiency was demonstrated on investigation. A high index of suspicion is required in these cases due to the frequent absence in children of classic symptoms of spinal extradural abscess.Conclusion: we advise an urgent MRI of the head and spine in such unexplained cases of Staphylococcus aureus meningitis, to allow early diagnosis and management of occult underlying pathology. Such an approach will minimise the risk of potentially catastrophic neurological sequelae. [ABSTRACT FROM AUTHOR]

Primary extraosseous Ewing sarcoma is a rare entity, especially in the spinal epidural site. Less than 20 cases have been reported in the literature. Here, we present a previously healthy 12-year-old boy who complained of low back pain, progressive gait disturbance and weakness of right lower extremity for nearly one month before admission. Magnetic resonance imaging showed one solitary posterior extradural mass, measuring 4 × 2.2 × 2.1 cm, with severe cord compression at the level from T7 to T9. The mass appeared hypo-intense on both T1-weighted and T2-weighted images and homogeneous contrast enhancement after injection of gadolinium. He underwent laminectomies of T8 and T9 and complete resection of the tumor. The pathology confirmed a diagnosis of Ewing sarcoma after immunohistochemical staining. His profound neurological deficits recovered well and no recurrence was discovered after adjuvant chemotherapy and radiotherapy. The relevant literature is reviewed and the limited cases are also analyzed. [ABSTRACT FROM AUTHOR]

We have reviewed 16 children with extradural spinal tumors, both benign and malignant, treated from 1998 to 2006 in Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. The duration of symptomatology, clinical signs, radiological investigations, surgical approach, outcome and histopathological variation from the Western world was noted and evaluated. The age of these children ranged from 3 to 20 years. There were 11 boys and 5 girls. The duration of symptoms was 2–18 months, relatively longer in benign (mean 9.5 months) than malignant (mean 4.2 months) tumors. The follow-up ranged from 3 to 72 months and patients were graded preoperatively and postoperatively with the McCormick Functional Grading System. There was significant improvement in grade III–V patients, i.e. 74% of patients were grade III–IV at presentation, and only 35% at the last follow-up. There was deterioration from grade III to grade IV in 2 patients (PNET + metastatic adenocarcinoma) and 2 patients (neuroblastoma + Ewing’s sarcoma) maintained their grades of IV and V, respectively. There was a wide range of histological variants seen in our series and the patients were treated primarily with a suitable surgical approach and adjuvant chemoradiotherapy, wherever indicated. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

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Abstract: Background context: Most spinal arteriovenous malformations (AVMs) are dural arteriovenous fistulas in which a singularly intradural venous drainage emanates from an extradural nidus. A pure extradural spinal arteriovenous malformation (E-AVM), in the absence of a vertebral body (cavernous) hemangioma, is extremely rare, and full clinical, radiological, and operative descriptions are scant. Purpose: To fully document the rare occurrence of a symptomatic E-AVM producing spinal claudication. Study design: Case report. Patient sample: One patient. Outcome measures: Radiological and functional. Methods: This 62-year-old man presented with 6-month progressive spinal claudication, leg weakness, and diminished sensation. Electromyography revealed bilateral acute and chronic partial degeneration of L3–S1 nerve roots. Magnetic resonance imaging revealed moderate canal stenosis between L2–L4, with prominent epidural veins on the left at L3–L4. Spinal angiography was unsuccessful, and computed tomographic myelography merely confirmed minimal lumbosacral root filling. At decompressive L2–L4 laminectomy, inadvertent hemorrhage from varicose epidural veins released arterialized blood under considerable pressure. Only minor clinical improvement was noted after this procedure. Spinal angiography 6 weeks later subsequently confirmed an E-AVM on the left at L3–L4 which was successfully embolized. Results: Follow-up at 8 weeks after this procedure confirmed significantly increased walking distance, improved distal sensation, and normal power in both legs, with insignificant claudication. Conclusions: When associated with canal stenosis, E-AVMs may exacerbate claudication by both compressive and venous-hypertensive mechanisms. Treatment should be by embolization, with laminectomy deferred. [Copyright &y& Elsevier]

Objectives To assess the accuracy of the ‘hanging drop method’ for identifying the extradural space in anaesthetized dogs positioned in sternal or lateral recumbency. Study design Prospective randomized-experimental study. Animals Seventeen clinically healthy adult dogs, 10 females and seven males weighing 8.4–26.2 kg. Methods Dogs were positioned in either sternal ( n = 8) or lateral ( n = 9) recumbency under general anaesthesia. A 20 SWG spinal needle pre-filled with 0.9% saline was advanced through the skin into the lumbosacral extradural space and the response of the saline drop recorded, i.e. whether it: 1) was aspirated from the hub into the needle; 2) remained within the hub, or 3) moved synchronously with i) spontaneous respiration, ii) heart beat or iii) manual lung inflation. The position of the needle tip was ultimately determined by positive contrast radiography. Results One dog positioned in lateral recumbency was excluded from the study because bleeding occurred from the needle hub. Saline was aspirated into the needle in seven of eight dogs held in sternal recumbency but in none of the dogs positioned in lateral recumbency. Accurate needle tip placement in the extradural space was confirmed by positive contrast radiography in all dogs. Conclusion and clinical relevance The ‘hanging drop’ method, when performed with a spinal needle, appears to be a useful technique for identifying the location of the extradural space in anaesthetized medium-sized dogs positioned in sternal, but not in lateral recumbency. The technique may yield ‘false negative’ results when performed in dogs positioned in sternal recumbency. [ABSTRACT FROM AUTHOR]

Summary: Objective: Intracranial extension of infection represents a serious complication of sinusitis but with no clearly documented prevalence. The frontal sinus with its unique anatomical characteristics, has been singled out as a catalyst for intracranial spread, but without solid evidence. Our objective was to determine the prevalence of intracranial complications in pediatric acute frontal sinusitis and to test the claimed association. Methods: A retrospective chart review of all children (≤16 years of age) admitted over an 18 year period with sinusitis was undertaken in a tertiary children''s hosiptal. Included were those with acute disease (<3 months duration) that required active medical and/or surgical management. Patients with history of conditions that predispose to rhinosinusitis or intracranial infections were excluded. Data collected included demographics, sinuses involved, intracranial complications and their types, aspects of management, imaging, and mortality. Results: In our search 466 patients were included. Of these, 386 did not meet the inclusion criteria. Of the 80 remaining patients, 10 had no films or imaging data available for analysis. The 70 included patients ranged in age from 7 months to 15 years (mean 8.8, median 10). Forty-nine (70%) were males. Twenty-six required medical treatment and 44 (62.9%) required surgical therapy in addition. Forty-nine had orbital complications and 8 (11.4%) had intracranial complications. There was no mortality. The eight patients with intracranial complications ranged in age from 3 to 14 years (mean 12). Six were males. Of the 23 patients with frontal sinus involvement, 7 (30.4%) had intracranial complications. The odds ratio for developing intracranial complications if the frontal sinus was involved in the inflammatory process was 20 (95% CI 2.30–176.4). Conclusion: There is a high probability of developing intracranial complications in children who present with acute frontal sinusitis to a tertiary care hospital. This should prompt all involved specialists to insist on detailed radiological evaluation in this group, to halt preventable mortality and morbidity. [Copyright &y& Elsevier]

Pruritus following a single administration of 100 μg kg−1 of preservative-free morphine sulphate given via an extradural catheter was seen in a 580 kg horse. The catheter was placed in the first intercoccygeal space. Focal irritation, represented by both local alopecia over the left gluteal muscles and serum exudation, occurred 4–8 hours after injection. This was attributed to the extradural morphine administration. [ABSTRACT FROM AUTHOR]

Background: We report the clinical presentation, radiographic studies, intraoperative findings, histopathological analysis, and post-treatment outcome in 26 patients diagnosed with spinal synovial cysts (SSCs).Aims: To describe the clinical presentation, radiographic studies, operative findings, and postoperative follow-up in 26 patients with SSCs.Settings and Design: The study was retrospective in design, involving chart review. Individual patient data was tabulated and patterns were recognized.Materials and Methods: The charts for 26 patients who underwent surgical extirpation of SSC between April 1993 and October 2002 were retrospectively reviewed. Specifically, initial clinical presentation, pertinent radiographs (X-rays, magnetic resonance imaging, computed tomography), intraoperative findings, histopathology, and postoperative follow-up were noted.Statistical Analysis Used: Patient data was tabulated and analyzed for patterns in demographics, symptoms and histopathology.Results: SSCs were more common in females than males (17:9 ratio). Presenting symptoms were back pain with radiculopathy in 13 (50%), radicular pain in the absence of back pain in 10 (38%), and back pain without radicular pain in three (11%). In addition, 17 patients (65%) had sensory deficit, and 9 (35%) had motor deficit. Most SSCs occurred at the lumbar (19/26) or lumbosacral (5/26) regions, with only 2 (2/26) in the thoracic region. One patient had bilateral SSC at the L4-5 level. Intraoperatively, each cyst was located adjacent to a degenerated facet joint. These lesions could grossly be identified intraoperatively and histopathological confirmation was achieved in all the cases.Conclusions: SSCs are important lesions to consider in the differential diagnosis of lumbar epidural masses and surgical resection leads to significant improvement in the majority of cases. [ABSTRACT FROM AUTHOR]

Objective To compare the effects of intravenous (IV) and extradural (ED) methadone on end-tidal isoflurane concentration (Fe′ISO) and postoperative analgesic requirements in dogs undergoing femoro-tibial joint surgery. Study Design Randomized, blinded, clinical study. Animals Twenty-four healthy client-owned dogs undergoing surgical repair of ruptured cruciate ligaments. Methods Dogs were randomly assigned to two groups of 12 animals and received either ED or IV methadone (0.3 mg kg−1 diluted with saline to 0.2 mL kg−1). Pre-anaesthetic medication was IV acepromazine (0.05 mg kg−1). Anaesthesia was induced with propofol and maintained initially with an Fe′ISO of 1.0% delivered in oxygen. Methadone was injected with the dogs in sternal recumbency; the observer was unaware of the administration route. At 10 minutes (stimulation 1) and 20 minutes (stimulation 2) after methadone administration pelvic limb reflexes were tested by digit-clamping. The time at skin incision (stimulation 3), joint-capsule incision (stimulation 4), tibial tuberosity drilling (stimulation 5), fabellar suturing (stimulation 6) and extracapsular tightening (stimulation 7) were noted. Changes in heart rate (HR) and respiratory rate and arterial blood pressure associated with surgery were recorded along with the corresponding Fe′ISO. After 20 minutes of anaesthesia, Fe′ISO was decreased to the minimum required to maintain stable anaesthesia. Immediately after tracheal extubation, 1, 2, 3 and 6 hours postoperatively and on the morning after surgery, the degree of pain present was assessed using a numerical rating scale. The HR, respiratory rates and blood pressure were also recorded at these times. Serum cortisol and blood glucose concentrations were measured before pre-anaesthetic medication and at each postoperative pain scoring interval except at 1 and 2 hours. Ketoprofen (2 mg kg−1), carprofen (4 mg kg−1) or meloxicam (0.2 mg kg−1) were given by subcutaneous injection whenever pain scoring indicated moderate discomfort was present. Results Controlled ventilation was required in six dogs which stopped breathing after IV methadone. The median Fe′ISO at stimulus 5 was 1.0% in the IV and 0.83% in the ED group. At stimulus 6, Fe′ISO was 1.0% in the IV and 0.8% in the ED group; the difference was statistically significant ( p ≤ 0.05). There was no significant difference in the duration of postoperative analgesia associated with administration route. Conclusions Extradural methadone significantly reduces the isoflurane requirement compared with IV methadone during femoro-tibial joint surgery in dogs. Clinical relevance Extradural methadone provides safe and effective pain relief in dogs undergoing cruciate ligament repair. [ABSTRACT FROM AUTHOR]

Background and objectives: This study was designed to investigate whether single epidural droperidol or continuous epidural droperidol inhibit pruritus and postoperative nausea and vomiting induced by postoperative continuous epidural fentanyl administration, and to identify the optimal method of administering epidural droperidol. Methods: 120 ASA I-II patients undergoing subtotal gastrectomy with general anaesthesia combined with epidural anaesthesia were randomly allocated into three groups: control (no droperidol), single injection (droperidol 2.5 mg) and continuous group (droperidol 2.5 mg 2 day-1). Postoperatively the frequency and severity of pruritus and postoperative nausea and vomiting in all groups were compared during 48 h. Results: The frequency and severity of pruritus was significantly lower in both single injection and continuous groups than control group after epidural fentanyl administration (P < 0.05). The frequency and severity of postoperative nausea and vomiting was significantly lower in single injection group than control group after epidural fentanyl administration (P < 0.05). Conclusion: Epidural continuous droperidol is effective for reducing pruritus, and single epidural droperidol injection is effective for reducing pruritus and postoperative nausea and vomiting induced by postoperative continuous epidural fentanyl analgesia. [ABSTRACT FROM AUTHOR]