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151. Analysis of rare driving events in pediatric acute myeloid leukemia

Author

Noort, Sanne, van Oosterwijk, Jolieke, Ma, Jing, Garfinkle, Elizabeth A.R., Nance, Stephanie, Walsh, Michael, Song, Guangchun, Reinhardt, Dirk, Pigazzi, Martina, Locatelli, Franco, Hasle, Henrik, Abrahamsson, Jonas, Jarosova, Marie, Kelaidi, Charikleia, Polychronopoulou, Sophia, van den Heuvel-Eibrink, Marry M., Fornerod, Maarten, Gruber, Tanja A., Zwaan, C. Michel, Noort, Sanne, van Oosterwijk, Jolieke, Ma, Jing, Garfinkle, Elizabeth A.R., Nance, Stephanie, Walsh, Michael, Song, Guangchun, Reinhardt, Dirk, Pigazzi, Martina, Locatelli, Franco, Hasle, Henrik, Abrahamsson, Jonas, Jarosova, Marie, Kelaidi, Charikleia, Polychronopoulou, Sophia, van den Heuvel-Eibrink, Marry M., Fornerod, Maarten, Gruber, Tanja A., and Zwaan, C. Michel

Abstract

Elucidating genetic aberrations in pediatric acute myeloid leukemia (AML) provides insight in biology and may impact on risk-group stratification and clinical outcome. This study aimed to detect such aberrations in a selected series of samples without known (cyto)genetic aberration using molecular profiling. A cohort of 161 patients was selected from various study groups: DCOG, BFM, SJCRH, NOPHO and AEIOP. Samples were analyzed using RNA sequencing (n=152), whole exome (n=135) and/or whole genome sequencing (n=100). In 70 of 156 patients (45%), of whom RNA sequencing or whole genome sequencing was available, rearrangements were detected, 22 of which were novel; five involving ERG rearrangements and four NPM1 rearrangements. ERG rearrangements showed self-renewal capacity in vitro, and a distinct gene expression pattern. Gene set enrichment analysis of this cluster showed upregulation of gene sets derived from Ewing sarcoma, which was confirmed comparing gene expression profiles of AML and Ewing sarcoma. Furthermore, NPM1-rearranged cases showed cytoplasmic NPM1 localization and revealed HOXA/B gene overexpression, as described for NPM1 mutated cases. Single-gene mutations as identified in adult AML were rare. Patients had a median of 24 coding mutations (range, 7-159). Novel recurrent mutations were detected in UBTF (n=10), a regulator of RNA transcription. In 75% of patients an aberration with a prognostic impact could be detected. Therefore, we suggest these techniques need to become standard of care in diagnostics.

Published
2023

152. Diagnostic MRI characteristics of pediatric clear cell sarcoma of the kidney and rhabdoid tumor of the kidney: A retrospective multi-center SIOP-RTSG Radiology panel study

Author

Onderzoek Beeld, Cancer, Pathologie Pathologen staf, Pathologie Groep Van Diest, Speerpunt, Zorg en O&O, Child Health, MS Radiologie, van der Beek, Justine N., Schenk, Jens Peter, Watson, Tom A., Coma, Ana, Morosi, Carlo, Graf, Norbert, Chowdhury, Tanzina, Ramírez-Villar, Gema L., Spreafico, Filippo, Dzhuma, Kristina, Mokkink, Lidwine B., de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., Littooij, Annemieke S., Onderzoek Beeld, Cancer, Pathologie Pathologen staf, Pathologie Groep Van Diest, Speerpunt, Zorg en O&O, Child Health, MS Radiologie, van der Beek, Justine N., Schenk, Jens Peter, Watson, Tom A., Coma, Ana, Morosi, Carlo, Graf, Norbert, Chowdhury, Tanzina, Ramírez-Villar, Gema L., Spreafico, Filippo, Dzhuma, Kristina, Mokkink, Lidwine B., de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., and Littooij, Annemieke S.

Published
2023

153. Automated Deep Learning-Based Classification of Wilms Tumor Histopathology

Author

MS Radiotherapie, Cancer, Speerpunt, Zorg en O&O, Child Health, Pathologie Pathologen staf, van der Kamp, Ananda, de Bel, Thomas, van Alst, Ludo, Rutgers, Jikke, van den Heuvel-Eibrink, Marry M., Mavinkurve-Groothuis, Annelies M.C., van der Laak, Jeroen, de Krijger, Ronald R., MS Radiotherapie, Cancer, Speerpunt, Zorg en O&O, Child Health, Pathologie Pathologen staf, van der Kamp, Ananda, de Bel, Thomas, van Alst, Ludo, Rutgers, Jikke, van den Heuvel-Eibrink, Marry M., Mavinkurve-Groothuis, Annelies M.C., van der Laak, Jeroen, and de Krijger, Ronald R.

Published
2023

154. Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)

Author

PMC Medisch specialisten, PMC Research, Apotheek O&O&O, Cancer, Speerpunt, Zorg en O&O, Child Health, Rubio-San-Simón, Alba, van Eijkelenburg, Natasha K.A., Hoogendijk, Raoull, Hasle, Henrik, Niemeyer, Charlotte M., Dworzak, Michael N., Zecca, Marco, Lopez-Yurda, Marta, Janssen, Julie M., Huitema, Alwin D.R., van den Heuvel-Eibrink, Marry M., Laille, Eric J., van Tinteren, Harm, Zwaan, Christian M., PMC Medisch specialisten, PMC Research, Apotheek O&O&O, Cancer, Speerpunt, Zorg en O&O, Child Health, Rubio-San-Simón, Alba, van Eijkelenburg, Natasha K.A., Hoogendijk, Raoull, Hasle, Henrik, Niemeyer, Charlotte M., Dworzak, Michael N., Zecca, Marco, Lopez-Yurda, Marta, Janssen, Julie M., Huitema, Alwin D.R., van den Heuvel-Eibrink, Marry M., Laille, Eric J., van Tinteren, Harm, and Zwaan, Christian M.

Published
2023

155. Cancer risk in children, adolescents, and young adults conceived by ART in 1983-2011

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, Spaan, Mandy, Pontesilli, Martina, Van Den Belt-Dusebout, Alexandra W., Burger, Curt W., Van Den Heuvel-Eibrink, Marry M., Ravelli, Anita C.J., Goddijn, Mariëtte, Lambalk, Cornelis B., Roseboom, Tessa J., Van Leeuwen, Flora E., Speerpunt, Zorg en O&O, Cancer, Child Health, Spaan, Mandy, Pontesilli, Martina, Van Den Belt-Dusebout, Alexandra W., Burger, Curt W., Van Den Heuvel-Eibrink, Marry M., Ravelli, Anita C.J., Goddijn, Mariëtte, Lambalk, Cornelis B., Roseboom, Tessa J., and Van Leeuwen, Flora E.

Published
2023

156. The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study

Author

Zorg en O&O, Cancer, Child Health, Speerpunt, PMC Medisch specialisten, SCT patientenzorg, MS Radiotherapie, Houtman, Bente M, Walraven, Iris, de Grouw, Elke, van der Maazen, Richard W M, Kremer, Leontien C M, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M, Tissing, Wim J E, Bresters, Dorine, van der Pal, Helena J H, de Vries, Andrica C H, Louwerens, Marloes, van der Heiden-van der Loo, Margriet, Neggers, Sebastian J C, Janssens, Geert O, Blijlevens, Nicole M A, Lambeck, Annechien J A, Preijers, Frank, Loonen, Jacqueline J, Zorg en O&O, Cancer, Child Health, Speerpunt, PMC Medisch specialisten, SCT patientenzorg, MS Radiotherapie, Houtman, Bente M, Walraven, Iris, de Grouw, Elke, van der Maazen, Richard W M, Kremer, Leontien C M, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M, Tissing, Wim J E, Bresters, Dorine, van der Pal, Helena J H, de Vries, Andrica C H, Louwerens, Marloes, van der Heiden-van der Loo, Margriet, Neggers, Sebastian J C, Janssens, Geert O, Blijlevens, Nicole M A, Lambeck, Annechien J A, Preijers, Frank, and Loonen, Jacqueline J

Published
2023

157. MRI-based inter- and intrafraction motion analysis of the pancreatic tail and spleen as preparation for adaptive MRI-guided radiotherapy in neuroblastoma

Author

Klinisch Fysici i.o., Onderzoek Beeld, Cancer, Speerpunt, Zorg en O&O, Child Health, Klinische Fysica RT, MS Radiotherapie, Van Ommen, Fasco, le Quellenec, Gaelle A T, Willemsen-Bosman, Mirjam E, van Noesel, Max M, van den Heuvel-Eibrink, Marry M, Seravalli, Enrica, Kroon, Petra S, Janssens, Geert O, Klinisch Fysici i.o., Onderzoek Beeld, Cancer, Speerpunt, Zorg en O&O, Child Health, Klinische Fysica RT, MS Radiotherapie, Van Ommen, Fasco, le Quellenec, Gaelle A T, Willemsen-Bosman, Mirjam E, van Noesel, Max M, van den Heuvel-Eibrink, Marry M, Seravalli, Enrica, Kroon, Petra S, and Janssens, Geert O

Published
2023

158. Cellular senescence in kidney biopsies is associated with tubular dysfunction and predicts CKD progression in childhood cancer patients with karyomegalic interstitial nephropathy

Author

Pathologie Opleiding, Cancer, Nefrologie patientenzorg, Child Health, Pathologie Groep Goldschmeding, Speerpunt, Zorg en O&O, Nefrologie, Genetica Klinische Genetica, MS Radiotherapie, Pathologie Weefselfaciliteit en archief, Pathologie Pathologen staf, Circulatory Health, Knoppert, Sebastiaan N, Keijzer-Veen, Mandy G, Valentijn, Floris A, van den Heuvel-Eibrink, Marry M, Lilien, Marc R, van den Berg, Gerrit, Haveman, Lianne M, Stokman, Marijn F, Janssens, Geert O, van Kempen, Sven, Broekhuizen, Roel, Goldschmeding, Roel, Nguyen, Tri Q, Pathologie Opleiding, Cancer, Nefrologie patientenzorg, Child Health, Pathologie Groep Goldschmeding, Speerpunt, Zorg en O&O, Nefrologie, Genetica Klinische Genetica, MS Radiotherapie, Pathologie Weefselfaciliteit en archief, Pathologie Pathologen staf, Circulatory Health, Knoppert, Sebastiaan N, Keijzer-Veen, Mandy G, Valentijn, Floris A, van den Heuvel-Eibrink, Marry M, Lilien, Marc R, van den Berg, Gerrit, Haveman, Lianne M, Stokman, Marijn F, Janssens, Geert O, van Kempen, Sven, Broekhuizen, Roel, Goldschmeding, Roel, and Nguyen, Tri Q

Published
2023

159. Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review

Author

MS VPG/Gynaecologie, Cancer, Child Health, Grubliauskaite, Monika, van der Perk, M E Madeleine, Bos, Annelies M E, Meijer, Annelot J M, Gudleviciene, Zivile, van den Heuvel-Eibrink, Marry M, Rascon, Jelena, MS VPG/Gynaecologie, Cancer, Child Health, Grubliauskaite, Monika, van der Perk, M E Madeleine, Bos, Annelies M E, Meijer, Annelot J M, Gudleviciene, Zivile, van den Heuvel-Eibrink, Marry M, and Rascon, Jelena

Published
2023

160. Radiologic versus Segmentation Measurements to Quantify Wilms Tumor Volume on MRI in Pediatric Patients

Author

Zorgeenheid Kinderchirurgie Medisch, Cancer, Speerpunt, Child Health, Zorg en O&O, MS Radiologie, Beeldverwerking ISI, Buser, Myrthe A D, van der Steeg, Alida F W, Wijnen, Marc H W A, Fitski, Matthijs, van Tinteren, Harm, van den Heuvel-Eibrink, Marry M, Littooij, Annemieke S, van der Velden, Bas H M, Zorgeenheid Kinderchirurgie Medisch, Cancer, Speerpunt, Child Health, Zorg en O&O, MS Radiologie, Beeldverwerking ISI, Buser, Myrthe A D, van der Steeg, Alida F W, Wijnen, Marc H W A, Fitski, Matthijs, van Tinteren, Harm, van den Heuvel-Eibrink, Marry M, Littooij, Annemieke S, and van der Velden, Bas H M

Published
2023

161. Long-term nephrotoxicity in irradiated pediatric kidney tumor survivors: A systematic review

Author

MS Radiotherapie, Cancer, Intensieve zorg, PMC Medisch specialisten, Intensive care patientenzorg, Child Health, Nefrologie, Speerpunt, Zorg en O&O, Dávila Fajardo, Raquel, Raymakers-Janssen, Paulien, van Grotel, Martine, van Wösten-van Asperen, Roelie M, Terhaard, Christianus H, Lilien, Marc R, van den Heuvel-Eibrink, Marry M, Janssens, Geert O, MS Radiotherapie, Cancer, Intensieve zorg, PMC Medisch specialisten, Intensive care patientenzorg, Child Health, Nefrologie, Speerpunt, Zorg en O&O, Dávila Fajardo, Raquel, Raymakers-Janssen, Paulien, van Grotel, Martine, van Wösten-van Asperen, Roelie M, Terhaard, Christianus H, Lilien, Marc R, van den Heuvel-Eibrink, Marry M, and Janssens, Geert O

Published
2023

162. Validation of a modified bedside Pediatric Early Warning System score for detection of clinical deterioration in hospitalized pediatric oncology patients: A prospective cohort study

Author

Arts-assistenten Kinderen, Medische staf Anesthesiologie, Cancer, Circulatory Health, Speerpunt, Zorg en O&O, Child Health, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, PMC Medisch specialisten, Soeteman, Marijn, Kappen, Teus H., van Engelen, Martine, Marcelis, Maartje, Kilsdonk, Ellen, van den Heuvel-Eibrink, Marry M., Nieuwenhuis, Edward E.S., Tissing, Wim J.E., Fiocco, Marta, van Asperen, Roelie M.Wösten, Arts-assistenten Kinderen, Medische staf Anesthesiologie, Cancer, Circulatory Health, Speerpunt, Zorg en O&O, Child Health, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, PMC Medisch specialisten, Soeteman, Marijn, Kappen, Teus H., van Engelen, Martine, Marcelis, Maartje, Kilsdonk, Ellen, van den Heuvel-Eibrink, Marry M., Nieuwenhuis, Edward E.S., Tissing, Wim J.E., Fiocco, Marta, and van Asperen, Roelie M.Wösten

Published
2023

163. Hydrocortisone to reduce dexamethasone-induced neurobehavioral side-effects in children with acute lymphoblastic leukaemia—results of a double-blind, randomised controlled trial with cross-over design

Author

Kinderbewegingszorg patientenzorg, Arts-assistenten Kinderen, PMC Research, Speerpunt, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Zorg en O&O, MS Verloskunde, van Hulst, Annelienke M., van den Akker, Erica L.T., Verwaaijen, Emma J., Fiocco, Marta, Rensen, Niki, van Litsenburg, Raphaële R.L., Pluijm, Saskia M.F., Zwaan, C. Michel, van Santen, Hanneke M., Pieters, Rob, Evers, Andrea W.M., Grootenhuis, Martha A., van den Heuvel-Eibrink, Marry M., Kinderbewegingszorg patientenzorg, Arts-assistenten Kinderen, PMC Research, Speerpunt, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Zorg en O&O, MS Verloskunde, van Hulst, Annelienke M., van den Akker, Erica L.T., Verwaaijen, Emma J., Fiocco, Marta, Rensen, Niki, van Litsenburg, Raphaële R.L., Pluijm, Saskia M.F., Zwaan, C. Michel, van Santen, Hanneke M., Pieters, Rob, Evers, Andrea W.M., Grootenhuis, Martha A., and van den Heuvel-Eibrink, Marry M.

Published
2023

164. Somatic, Genetic and Epigenetic Changes in Nephrogenic Rests and Their Role in the Transformation to Wilms Tumors, a Systematic Review

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, Pathologie Pathologen staf, Bánki, Tessa, Drost, Jarno, van den Heuvel-Eibrink, Marry M., Mavinkurve-Groothuis, Annelies M.C., de Krijger, Ronald R., Speerpunt, Zorg en O&O, Cancer, Child Health, Pathologie Pathologen staf, Bánki, Tessa, Drost, Jarno, van den Heuvel-Eibrink, Marry M., Mavinkurve-Groothuis, Annelies M.C., and de Krijger, Ronald R.

Published
2023

165. Long term safety of growth hormone replacement therapy in survivors of cancer and tumors of the pituitary region

Author

Cancer, MS Radiotherapie, Speerpunt, Child Health, Zorg en O&O, Bolier, Melissa, Van der Lelij, Aart-Jan, Maxima, Princess, van den Heuvel-Eibrink, Marry M, Neggers, Sebastian J C M M, Cancer, MS Radiotherapie, Speerpunt, Child Health, Zorg en O&O, Bolier, Melissa, Van der Lelij, Aart-Jan, Maxima, Princess, van den Heuvel-Eibrink, Marry M, and Neggers, Sebastian J C M M

Published
2023

166. Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, Clasen, Nikita H Z, van der Perk, M E Madeleine, Neggers, Sebastian J C M M, Bos, Annelies M E, van den Heuvel-Eibrink, Marry M, Speerpunt, Zorg en O&O, Cancer, Child Health, Clasen, Nikita H Z, van der Perk, M E Madeleine, Neggers, Sebastian J C M M, Bos, Annelies M E, and van den Heuvel-Eibrink, Marry M

Published
2023

167. Thyroid dysfunction during treatment with systemic antineoplastic therapy for childhood cancer: a systematic review

Author

MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, van Dalen, Elvira C, MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, and van Dalen, Elvira C

Published
2023

168. Novel Adaption of the SARC-F Score to Classify Pediatric Hemato-Oncology Patients with Functional Sarcopenia

Author

Onderzoek Beeld, Cancer, PMC Medisch specialisten, Speerpunt, Zorg en O&O, Child Health, Verwaaijen, Emma J, van der Torre, Patrick, Vormoor, Josef, Pieters, Rob, Fiocco, Marta, Hartman, Annelies, van den Heuvel-Eibrink, Marry M, Onderzoek Beeld, Cancer, PMC Medisch specialisten, Speerpunt, Zorg en O&O, Child Health, Verwaaijen, Emma J, van der Torre, Patrick, Vormoor, Josef, Pieters, Rob, Fiocco, Marta, Hartman, Annelies, and van den Heuvel-Eibrink, Marry M

Published
2023

169. Clinical evaluation of late outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER 2 study

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Endocrinologie patientenzorg, Brain, PMC Research, Klinische Fysica RT, PMC Medisch specialisten, Feijen, Elizabeth A.M., Teepen, Jop C., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van der Heiden-van der Loo, Margriet, van der Pal, Helena J.H., de Vries, Andrica C.H., Louwerens, Marloes, Bresters, Dorine, Versluys, Birgitta, de Ridder, Hanneke, Veening, Margreet, van Leeuwen, Flora E., Grootenhuis, Martha, Maurice-Stam, Heleen, van Santen, Hanneke M., Neggers, Sebastian J.C.M.M., Pluijm, Saskia, den Hartogh, Jaap, Ronckers, Cécile M., Tissing, Wim J.E., Loonen, Jacqueline J., Kremer, Leontien C.M., Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Endocrinologie patientenzorg, Brain, PMC Research, Klinische Fysica RT, PMC Medisch specialisten, Feijen, Elizabeth A.M., Teepen, Jop C., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van der Heiden-van der Loo, Margriet, van der Pal, Helena J.H., de Vries, Andrica C.H., Louwerens, Marloes, Bresters, Dorine, Versluys, Birgitta, de Ridder, Hanneke, Veening, Margreet, van Leeuwen, Flora E., Grootenhuis, Martha, Maurice-Stam, Heleen, van Santen, Hanneke M., Neggers, Sebastian J.C.M.M., Pluijm, Saskia, den Hartogh, Jaap, Ronckers, Cécile M., Tissing, Wim J.E., Loonen, Jacqueline J., and Kremer, Leontien C.M.

Published
2023

170. Direct correlation of MRI with histopathology in pediatric renal tumors through the use of a patient-specific 3-D-printed cutting guide: a feasibility study

Author

Onderzoek Beeld, Cancer, Pathologie Pathologen staf, Zorgeenheid Kinderchirurgie Medisch, Child Health, MS Radiologie, van der Beek, Justine N., Fitski, Matthijs, de Krijger, Ronald R., Wijnen, Marc H.W.A., van den Heuvel-Eibrink, Marry M., Vermeulen, Marijn A., van der Steeg, Alida F.W., Littooij, Annemieke S., Onderzoek Beeld, Cancer, Pathologie Pathologen staf, Zorgeenheid Kinderchirurgie Medisch, Child Health, MS Radiologie, van der Beek, Justine N., Fitski, Matthijs, de Krijger, Ronald R., Wijnen, Marc H.W.A., van den Heuvel-Eibrink, Marry M., Vermeulen, Marijn A., van der Steeg, Alida F.W., and Littooij, Annemieke S.

Published
2023

171. Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm

Author

Genetica, Genetica Oper.Mang. Clinical Genetics, Cancer, Child Health, Speerpunt, Zorg en O&O, Genetica Klinische Genetica, Pathologie Moleculair, Genetica Sectie Genoomdiagnostiek, PMC Medisch specialisten, Onderzoek Beeld, Bakhuizen, Jette J., Hopman, Saskia M.J., Bosscha, Machteld I., Dommering, Charlotte J., van den Heuvel-Eibrink, Marry M., Hol, Janna A., Kester, Lennart A., Koudijs, Marco J., Langenberg, Karin P.S., Loeffen, Jan L.C., van der Lugt, Jasper, Moll, Annette C., van Noesel, Max M., Smetsers, Stephanie E., de Vos-Kerkhof, Evelien, Merks, Johannes H.M., Kuiper, Roland P., Jongmans, Marjolijn C.J., Genetica, Genetica Oper.Mang. Clinical Genetics, Cancer, Child Health, Speerpunt, Zorg en O&O, Genetica Klinische Genetica, Pathologie Moleculair, Genetica Sectie Genoomdiagnostiek, PMC Medisch specialisten, Onderzoek Beeld, Bakhuizen, Jette J., Hopman, Saskia M.J., Bosscha, Machteld I., Dommering, Charlotte J., van den Heuvel-Eibrink, Marry M., Hol, Janna A., Kester, Lennart A., Koudijs, Marco J., Langenberg, Karin P.S., Loeffen, Jan L.C., van der Lugt, Jasper, Moll, Annette C., van Noesel, Max M., Smetsers, Stephanie E., de Vos-Kerkhof, Evelien, Merks, Johannes H.M., Kuiper, Roland P., and Jongmans, Marjolijn C.J.

Published
2023

175. LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

Author

Helsmoortel, Hetty H., Bresolin, Silvia, Lammens, Tim, Cavé, Hélène, Noellke, Peter, Caye, Aurélie, Ghazavi, Farzaneh, de Vries, Andrica, Hasle, Henrik, Labarque, Veerle, Masetti, Riccardo, Stary, Jan, van den Heuvel-Eibrink, Marry M., Philippé, Jan, Van Roy, Nadine, Benoit, Yves, Speleman, Frank, Niemeyer, Charlotte, Flotho, Christian, Basso, Giuseppe, te Kronnie, Geertruy, Van Vlierberghe, Pieter, and De Moerloose, Barbara

Published
2016
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176. Positive and negative survivor-specific psychosocial consequences of childhood cancer: the DCCSS-LATER 2 psycho-oncology study

Author

Maas, Anne, Maurice-Stam, Heleen, van der Aa-van Delden, Alied M., van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Tissing, Wim J.E., Loonen, Jacqueline J., van der Pal, Helena J.H., de Vries, Andrica C.H., van den Heuvel-Eibrink, Marry M., Janssens, Geert O., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A.B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C.M., van Gorp, Marloes, Grootenhuis, Martha A., and Pediatrics

Subjects
SDG 3 - Good Health and Well-being
Abstract

Purpose: Numerous studies investigated generic psychosocial outcomes in survivors of childhood cancer (CCS). The present study aimed to describe survivor-specific psychosocial consequences in CCS, and to identify socio-demographic and medical associated factors. Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963–2001) part 2 (age ≥ 18 years, diagnosed < 18 years, ≥ 5 years since diagnosis) completed the Benefit & Burden Scale (BBSC) and the Impact of Cancer–Childhood Cancer (IOC-CS). Items were scored on a 5-point Likert scale (range 1–5). We examined outcomes with descriptive statistics, and socio-demographic and medical associated factors with regression analyses, corrected for multiple testing (p < 0.004). Results: CCS, N = 1713, age mean (M) 36 years, 49% female, ≥ 15 years since diagnosis, participated. On average, CCS reported ‘somewhat’ Benefit (M = 2.9), and ‘not at all’ to ‘a little’ Burden (M = 1.5) of childhood cancer. Average scores on IOC-CS’ positive impact scales ranged from 2.5 (Personal Growth) to 4.1 (Socializing), and on the negative impact scales from 1.4 (Financial Problems) to 2.4 (Thinking/Memory). Apart from cognitive problems, CCS reported challenges as worries about relationship status, fertility, and how cancer had affected siblings. Female sex was associated with more Personal Growth, and more negative impact. CCS more highly educated, partnered, and employed had higher positive and lower negative impact. CCS older at diagnosis reported more positive impact. CNS tumor survivors and those who had head/cranium radiotherapy had higher negative impact. CNS tumor survivors reported less positive impact. Conclusion and implications: The majority of CCS reported positive impact of cancer while most CCS reported little negative impact. While this may indicate resiliency in most CCS, health care providers should be aware that they can also experience survivor-specific challenges that warrant monitoring/screening, information provision and psychosocial support.

Published
2023

177. Psychosocial outcomes in long-term Dutch adult survivors of childhood cancer: The DCCSS-LATER 2 psycho-oncology study

Author

Maas, Anne, Maurice-Stam, Heleen, Kremer, Leontien C.M., van der Aa-van Delden, Alied, van Dulmen-den Broeder, Eline, Tissing, Wim J.E., Loonen, Jacqueline J., van der Pal, Helena J.H., de Vries, Andrica C.H., van den Heuvel-Eibrink, Marry M., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, van der Heiden-van der Loo, Margriet, van Gorp, Marloes, Grootenhuis, Martha, and Pediatrics

Subjects
SDG 3 - Good Health and Well-being
Abstract

Background: This study compares a comprehensive range of psychosocial outcomes of adult childhood cancer survivors (CCS) to general population-based references and identifies sociodemographic and medical risk factors. Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963–2001) part 2 (attained age ≥18 years, diagnosed

Published
2023

178. Correction:Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) (Cancers, (2020), 12, (3745), 10.3390/cancers12123745)

Author

van de Velde, Mirjam Esther, Kaspers, Gertjan J. L., Abbink, Floor C. H., Twisk, Jos W. R., van der Sluis, Inge M., van den Bos, Cor, van den Heuvel-Eibrink, Marry M., Segers, Heidi, Chantrain, Christophe, van der Werff ten Bosch, Jutte, Willems, Leen, van den Berg, Marleen H., Pediatrics, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, AII - Cancer immunology, Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, and APH - Methodology

Abstract

Error in Table In the original publication, there was a mistake in Table 1 as published [1]. The number of patients with death was swapped between the one-hour administration group and the push administration group. The corrected Table 1 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Published
2023

181. Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015).

Author

Rubio-San-Simón, Alba, van Eijkelenburg, Natasha K. A., Hoogendijk, Raoull, Hasle, Henrik, Niemeyer, Charlotte M., Dworzak, Michael N., Zecca, Marco, Lopez-Yurda, Marta, Janssen, Julie M., Huitema, Alwin D. R., van den Heuvel-Eibrink, Marry M., Laille, Eric J., van Tinteren, Harm, and Zwaan, Christian M.

Subjects
AZACITIDINE, CHILD patients, HEMATOPOIETIC stem cell transplantation, CONSORTIA, MYELODYSPLASTIC syndromes
Abstract

Background: Advanced myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematological malignancies in children. A second allograft is recommended if a relapse occurs after hematopoietic stem cell transplantation, but the outcome is poor. Objective: We conducted a phase I/II multicenter study to evaluate the safety, pharmacokinetics, and activity of azacitidine in children with relapsed MDS/JMML prior to the second hematopoietic stem cell transplantation. Methods: Patients enrolled from June 2013 to March 2019 received azacitidine intravenously/subcutaneously once daily on days 1–7 of a 28-day cycle. The MDS and JMML cohorts followed a two-stage design separately, with a safety run-in for JMML. Response and safety data were used to evaluate efficacy and establish the recommended dose. Pharmacokinetics was also analyzed. The study closed prematurely because of low recruitment. Results: Six patients with MDS and four patients with JMML received a median of three and five cycles, respectively. Azacitidine 75 mg/m2 was well tolerated and plasma concentration–time profiles were similar to observed in adults. The most prevalent grade 3–4 adverse event was myelotoxicity. No responses were seen in patients with MDS, but 83% achieved stable disease; four patients underwent an allotransplant. Overall response rate in the JMML cohort was 75% (two complete responses; one partial response) and all responders underwent hematopoietic stem cell transplantation. One-year overall survival was 67% (95% confidence interval 38–100) in MDS and 50% (95% confidence interval 19–100) in JMML. Conclusions: Azacitidine 75 mg/m2 prior to a second hematopoietic stem cell transplantation is safe in children with relapsed MDS/JMML. Although the long-term advantage remains to be assessed, this study suggests that azacitidine is an efficacious option for relapsed JMML. Clinical Trial Registration: EudraCT 2010-022235-10. [ABSTRACT FROM AUTHOR]

Published
2023
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183. Psychosocial functioning of adult siblings of Dutch very long‐term survivors of childhood cancer: DCCSS‐LATER 2 psycho‐oncology study.

Author

Joosten, Mala M. H., van Gorp, Marloes, van Dijk, Jennifer, Kremer, Leontien C. M., van Dulmen‐den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel‐Eibrink, Marry M., Ronckers, Cécile, Bresters, Dorine, Louwerens, Marloes, Neggers, Sebastian J. C. C. M., van der Heiden‐van der Loo, Margriet, Maurice‐Stam, Heleen, Grootenhuis, Martha A., Versluys, Birgitta, van Leeuwen, Flora, and van der Steeg, Lideke

Subjects
PSYCHO-oncology, PSYCHOSOCIAL functioning, CHILDHOOD cancer, DUTCH people, POST-traumatic stress, CANCER survivors
Abstract

Objective: To describe psychosocial outcomes among adult siblings of very long‐term childhood cancer survivors (CCS), to compare these outcomes to reference populations and to identify factors associated with siblings' psychosocial outcomes. Methods: Siblings of survivors (diagnosed <18 years old, between 1963 and 2001, >5 years since diagnosis) of the Dutch Childhood Cancer Survivor Study DCCSS‐LATER cohort were invited to complete questionnaires on HRQoL (TNO‐AZL Questionnaire for Adult's HRQoL), anxiety/depression (Hospital Anxiety and Depression Scale), post‐traumatic stress (Self‐Rating Scale for Post‐traumatic Stress Disorder), self‐esteem (Rosenberg Self‐Esteem Scale) and benefit and burden (Benefit and Burden Scale for Children). Outcomes were compared to a reference group if available, using Mann‐Whitney U and chi‐Square tests. Associations of siblings' sociodemographic and CCS' cancer‐related characteristics with the outcomes were assessed with mixed model analysis. Results: Five hundred five siblings (response rate 34%, 64% female, mean age 37.5, mean time since diagnosis 29.5) of 412 CCS participated. Siblings had comparable HRQoL, anxiety and self‐esteem to references with no or small differences (r = 0.08−0.15, p < 0.05) and less depression. Proportions of symptomatic PTSD were very small (0.4%−0.6%). Effect sizes of associations of siblings' sociodemographic and CCS cancer‐related characteristics were mostly small to medium (β = 0.19−0.67, p < 0.05) and no clear trend was found in the studied associated factors for worse outcomes. Conclusions: On the very long‐term, siblings do not have impaired psychosocial functioning compared to references. Cancer‐related factors seem not to impact siblings' psychosocial functioning. Early support and education remain essential to prevent long‐term consequences. [ABSTRACT FROM AUTHOR]

Published
2023
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184. Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia

Author

Bertrums, Eline J.M., primary, Smith, Jenny L., additional, Harmon, Lauren, additional, Ries, Rhonda E., additional, Wang, Yi-Cheng J., additional, Alonzo, Todd A., additional, Menssen, Andrew J., additional, Chisholm, Karen M., additional, Leonti, Amanda R., additional, Tarlock, Katherine, additional, Ostronoff, Fabiana, additional, Pogosova-Agadjanyan, Era L., additional, Kaspers, Gertjan J.L., additional, Hasle, Henrik, additional, Dworzak, Michael, additional, Walter, Christiane, additional, Muhlegger, Nora, additional, Morerio, Cristina, additional, Pardo, Laura, additional, Hirsch, Betsy, additional, Raimondi, Susana, additional, Cooper, Todd M., additional, Aplenc, Richard, additional, Gamis, Alan S., additional, Kolb, Edward A., additional, Farrar, Jason E., additional, Stirewalt, Derek, additional, Ma, Xiaotu, additional, Shaw, Tim I., additional, Furlan, Scott N., additional, Brodersen, Lisa Eidenschink, additional, Loken, Michael R., additional, Van den Heuvel-Eibrink, Marry M., additional, Zwaan, C. Michel, additional, Triche, Timothy J., additional, Goemans, Bianca F., additional, and Meshinchi, Soheil, additional

Published
2023
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186. Correction: van de Velde et al. Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial). Cancers 2020, 12, 3745

Author

van de Velde, Mirjam Esther, primary, Kaspers, Gertjan J. L., additional, Abbink, Floor C. H., additional, Twisk, Jos W. R., additional, van der Sluis, Inge M., additional, van den Bos, Cor, additional, van den Heuvel-Eibrink, Marry M., additional, Segers, Heidi, additional, Chantrain, Christophe, additional, van der Werff ten Bosch, Jutte, additional, Willems, Leen, additional, and van den Berg, Marleen H., additional

Published
2023
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187. Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm

Author

Bakhuizen, Jette J., primary, Hopman, Saskia M. J., additional, Bosscha, Machteld I., additional, Dommering, Charlotte J., additional, van den Heuvel-Eibrink, Marry M., additional, Hol, Janna A., additional, Kester, Lennart A., additional, Koudijs, Marco J., additional, Langenberg, Karin P. S., additional, Loeffen, Jan L. C., additional, van der Lugt, Jasper, additional, Moll, Annette C., additional, van Noesel, Max M., additional, Smetsers, Stephanie E., additional, de Vos-Kerkhof, Evelien, additional, Merks, Johannes H. M., additional, Kuiper, Roland P., additional, and Jongmans, Marjolijn C. J., additional

Published
2023
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188. Clinical evaluation of late outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER 2 study

Author

Feijen, Elizabeth A. M., primary, Teepen, Jop C., additional, van Dulmen‐den Broeder, Eline, additional, van den Heuvel‐Eibrink, Marry M., additional, van der Heiden‐van der Loo, Margriet, additional, van der Pal, Helena J. H., additional, de Vries, Andrica C. H., additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, Versluys, Birgitta, additional, de Ridder, Hanneke, additional, Veening, Margreet, additional, van Leeuwen, Flora E., additional, Grootenhuis, Martha, additional, Maurice‐Stam, Heleen, additional, van Santen, Hanneke M., additional, Neggers, Sebastian J. C. M. M., additional, Pluijm, Saskia, additional, den Hartogh, Jaap, additional, Ronckers, Cécile M., additional, Tissing, Wim J. E., additional, Loonen, Jacqueline J., additional, and Kremer, Leontien C. M., additional

Published
2023
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191. Omission of doxorubicin from the treatment of stage II–III, intermediate-risk Wilms' tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial

Author

Pritchard-Jones, Kathy, Bergeron, Christophe, de Camargo, Beatriz, van den Heuvel-Eibrink, Marry M, Acha, Tomas, Godzinski, Jan, Oldenburger, Foppe, Boccon-Gibod, Liliane, Leuschner, Ivo, Vujanic, Gordan, Sandstedt, Bengt, de Kraker, Jan, van Tinteren, Harm, and Graf, Norbert

Published
2015
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196. Patterns of Hearing Loss in Irradiated Survivors of Head and Neck Rhabdomyosarcoma

Author

Diepstraten, Franciscus A., primary, Wiersma, Jan, additional, Schoot, Reineke A., additional, Knops, Rutger R. G., additional, Zuur, Charlotte L., additional, Meijer, Annelot J. M., additional, Dávila Fajardo, Raquel, additional, Pieters, Bradley R., additional, Balgobind, Brian V., additional, Westerveld, Henrike, additional, Freling, Nicole, additional, van Tinteren, Harm, additional, Smeele, Ludwig E., additional, Bel, Arjan, additional, van den Heuvel-Eibrink, Marry M., additional, Stokroos, Robert J., additional, Merks, Johannes H. M., additional, Hoetink, Alexander E., additional, and Hol, Marinka L. F., additional

Published
2022
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197. Frailty and Sarcopenia within the Earliest Dutch Childhood Cancer Survivor Cohort (n=2,003): A Dccss-Later Study

Author

van Atteveld, Jenneke E., primary, de Winter, Demi T.C., additional, Pluimakers, Vincent G., additional, Fiocco, Marta, additional, Nievelstein, Rutger A.J., additional, Hobbelink, Monique G.G., additional, Kremer, Leontien C.M., additional, Ronckers, Cécile M., additional, Grootenhuis, Martha A., additional, Maurice-Stam, Heleen, additional, Tissing, Wim J.E., additional, de Vries, Andrica C.H., additional, Loonen, Jacqueline J., additional, Van Dulmen-den Broeder, Eline, additional, van der Pal, Helena J., additional, Pluijm, Saskia, additional, van der Heiden-van der Loo, Margriet, additional, Versluys, Birgitta, additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, van Santen, Hanneke M., additional, Hoefer, Imo, additional, van den Berg, Sjoerd A.A., additional, Hoeijmakers, Jan H.J., additional, Neggers, Sebastian J.C.M.M., additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2022
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198. Hydrocortisone or Placebo to Reduce Dexamethasone-Induced Neurobehavioral Side Effects: Results of a Phase 3 National, Double-Blind, Placebo-Controlled Randomized Trial with Crossover Design

Author

van Hulst, Annelienke M., primary, van den Akker, Erica L.T., additional, Verwaaijen, Emma J., additional, Fiocco, Marta, additional, Rensen, Niki, additional, van Litsenburg, Raphaële R.L., additional, Pluijm, Saskia M.F., additional, Zwaan, C. Michel, additional, Van Santen, Hanneke M., additional, Pieters, Rob, additional, Evers, Andrea W.M., additional, Grootenhuis, Martha A., additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2022
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199. Modifiable Risk Factors Are Associated with Reduced Bone Mineral Density and Fractures in a National Cohort of 2,003 Dutch Childhood Cancer Survivors

Author

de Winter, Demi T.C., primary, Van Atteveld, Jenneke E., additional, Pluimakers, Vincent G., additional, Fiocco, Marta, additional, Nievelstein, Rutger A.J., additional, Hobbelink, Monique G.G., additional, de Vries, Andrica C.H., additional, Loonen, Jacqueline J., additional, Van Dulmen-den Broeder, Eline, additional, van der Pal, Helena J., additional, Pluijm, Saskia M.F., additional, Kremer, Leontien C.M., additional, Ronckers, Cécile M., additional, van der Heiden-van der Loo, Margriet, additional, Versluys, Birgitta, additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, van Santen, Hanneke M., additional, Olsson, Daniel S., additional, Hoefer, Imo, additional, van den Berg, Sjoerd A.A., additional, den Hartogh, Jaap, additional, Tissing, Wim J.E., additional, Neggers, Sebastian J.C.M.M., additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2022
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200. Retrospective Lineage Tracing of Pediatric Acute Myeloid Leukemia Using Single-Cell Whole Genome Sequencing

Author

Bertrums, Eline J.M., primary, Middelkamp, Sjors, additional, van der Werf, Inge M., additional, Manders, Freek, additional, Brandsma, Arianne M., additional, Groenen, Niels M., additional, Verheul, Mark, additional, van Roosmalen, Markus J., additional, Zwaan, C. Michel, additional, van den Heuvel-Eibrink, Marry M., additional, Goemans, Bianca F., additional, and Van Boxtel, Ruben, additional

Published
2022
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