[Objective] Multi-campus operation is common in Chinese higher education, where most universities run several campuses within the same or across different provinces. Although this model offers educational advantages, it presents challenges in constructing and sharing resources between diverse campuses, talent cultivation models, and university management systems. A considerable challenge is the development and collaboration of research infrastructure. Effective management of large instruments and their operations is crucial for supporting discipline construction and scientific research in universities. Under multi-campus operation, factors such as management mechanisms, technological advancements and exchange, and technical management personnel directly impact the efficacy of the open sharing of large-scale instrument platforms in universities. Exploring rational configuration, collaborative management, and open sharing of these large-scale instruments among multiple campuses--especially those in different locations--is crucial for research. [Methods] This study first summarizes the challenges in the open sharing of large-scale instruments across campuses, including issues related to management mechanisms, technological exchange and development, and technical management personnel. From the literature, this study summarizes practices and experiences from well-known international universities regarding cross-regional instrument sharing. Key practices include proactive attitudes among technical personnel, incentivizing management models, and sound laws and regulations. Considering the actual management practices of Beijing Normal University's campuses in Beijing and Zhuhai, several measures were summarized to improve instrument sharing efficiency, which includes standardizing procedures for large-scale instrument verification and acceptance, establishing an instrument information website, promoting instruments, strengthening technological exchange and integrated management, implementing instrument classification and grading management, and implementing incentive measures. For example, in mass spectrometry instruments, measures such as establishing information interconnection between the instruments on both campuses, determining unified management standards, and conducting proficiency testing using the same standard samples at both campuses were implemented. Additionally, a collaborative management method for mass spectrometry instruments between the two campuses was proposed. [Results] Concerning prevalent multi-campus universities where large-scale instruments are scarce yet important, exploring collaborative management methods and establishing a shared operational mechanism are vital. By implementing unified management practices and incentive mechanisms, considering the shared needs of researchers and the workload of instrument managers, effective communication and assistance between campus instrument platforms can prevent duplicate purchases of large-scale instruments, improve utilization efficiency, and maximize research funding effectiveness. [Conclusions] This study summarizes the practices and experiences of Beijing Normal University's Beijing and Zhuhai campuses in collaborative management and open sharing of instruments. These insights and suggestions provide guidance for managing and sharing scientific research instrument platforms under the cross-campus operation and remote education models. [ABSTRACT FROM AUTHOR]