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206. Inducible deletion of endothelial cell EfnB2 attenuates neuromuscular regeneration in mouse skeletal muscle

Author

Aaron Morton, Nicole Jacobsen, Alexandra Diller, DD Cornelison, and Steven Segal

Subjects
Physiology
Abstract

Background: Acute injury of skeletal muscle disrupts myofibers, microvessels and neuromuscular junctions (NMJs). While myofiber regeneration is well-characterized, little is known of concurrent events in microvessels and motor nerves following injury. Endothelial cell [EC] ephrin B2 [EfnB2] is required for sprouting angiogenesis during embryonic development, for promoting vascularization of tumors in the adult, and for microvascular-dependent guidance of axon regeneration following nerve resection. Hypothesis: We hypothesized that following acute injury to skeletal muscle 1) EC EfnB2 is required for restoring microvascular volume; and 2) loss of EC EfnB2 would impair recovery of neuromuscular structure and function. Methods: Mice (male and female, age 3-5 months) were bred for EC-specific conditional knockout [CKO] of EfnB2 following tamoxifen injection; noninjected CKO mice served as “wildtype” controls [WT]. Following injury by local injection of the myotoxin BaCl2, the gluteus maximus [GM] muscle was studied for microvascular analysis or the tibialis anterior [TA] muscle was evaluated for recovery of neuromuscular function. Mice were studied (n=4-6/group) at 3 timepoints for vascular studies (0, 5, and 10 days post injury [dpi]) and 2 timepoints for neuromuscular structure and function (0 and 10 dpi). Results: Intravascular staining with fluorescent wheat germ agglutinin revealed a diminished microvascular area in the GM of CKO mice at 5 dpi vs. 10 dpi (means ± SE; CKO 5 dpi 35.5% ± 2.5 vs. CKO 10 dpi 49.8% ± 3.9, P Support: NIH grant F32 HL-152558 (NLJ), APS Postdoctoral Fellowship (ABM), NIH LRP (ABM), Margaret Proctor Mulligan Fellowship, MU (NLJ, SSS), NIH R01 AR078045 (DDC), School of Medicine Development Award, MU (SSS), NIH MERIT Award R37 HL-041026 (SSS). This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Published
2023
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208. Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer

Author

John S. Lazo, Elizabeth R. Sharlow, Robert Cornelison, Duncan J. Hart, Danielle C. Llaneza, Anna J. Mendelson, Ettore J. Rastelli, Nikhil R. Tasker, Charles N. Landen, and Peter Wipf

Subjects
ovarian cancer, protein tyrosine phosphatase, drug target validation, cell migration, IL-6, drug synergy, Microbiology, QR1-502
Abstract

High grade serous ovarian cancer (OvCa) frequently becomes drug resistant and often recurs. Consequently, new drug targets and therapies are needed. Bioinformatics-based studies uncovered a relationship between high Protein Tyrosine Phosphatase of Regenerating Liver-3 (PRL3 also known as PTP4A3) expression and poor patient survival in both early and late stage OvCa. PTP4A3 mRNA levels were 5–20 fold higher in drug resistant or high grade serous OvCa cell lines compared to nonmalignant cells. JMS-053 is a potent allosteric small molecule PTP4A3 inhibitor and to explore further the role of PTP4A3 in OvCa, we synthesized and interrogated a series of JMS-053-based analogs in OvCa cell line-based phenotypic assays. While the JMS-053 analogs inhibit in vitro PTP4A3 enzyme activity, none were superior to JMS-053 in reducing high grade serous OvCa cell survival. Because PTP4A3 controls cell migration, we interrogated the effect of JMS-053 on this cancer-relevant process. Both JMS-053 and CRISPR/Cas9 PTP4A3 depletion blocked cell migration. The inhibition caused by JMS-053 required the presence of PTP4A3. JMS-053 caused additive or synergistic in vitro cytotoxicity when combined with paclitaxel and reduced in vivo OvCa dissemination. These results indicate the importance of PTP4A3 in OvCa and support further investigations of the lead inhibitor, JMS-053.

Published
2021
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209. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy

Author

Harris, Alexandra R., Esparza, Savieay, Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., Munson, Jennifer M., Harris, Alexandra R., Esparza, Savieay, Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., and Munson, Jennifer M.

Abstract

Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence shows it can affect the tumor stroma, unintentionally promoting cancer malignancy. After treatment of primary tumors, remaining drugs drain via lymphatics. Though all drugs interact with the lymphatics, we know little of their impact on them. Here, we show a previously unknown effect of platinums, a widely used class of chemotherapeutics, to directly induce systemic lymphangiogenesis and activation. These changes are dose-dependent, long-lasting, and occur in healthy and cancerous tissue in multiple mouse models of breast cancer. We found similar effects in human ovarian and breast cancer patients whose treatment regimens included platinums. Carboplatin treatment of healthy mice prior to mammary tumor inoculation increased cancer metastasis as compared to no pre-treatment. These platinum-induced phenomena could be blocked by VEGFR3 inhibition. These findings have implications for cancer patients receiving platinums and may support the inclusion of anti-VEGFR3 therapy into treatment regimens or differential design of treatment regimens to alter these potential effects.

Published
2022

210. Library Now Learning Support

Author

Cornelison, Zach

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Zach Cornelison Vickie Denz and Kasey Correll, Library& Archives Paras, are available to help students answer a variety of questions. Since May 2022, the library has been packed full [...]

Published
2023

211. A method for the development of cranial fracture histology slides

Author

Carolyn V, Isaac, Jered B, Cornelison, Clara J, Devota, Kristi, Bailey, and Jonathan, Langworthy

Subjects
Fracture Healing, Fractures, Bone, Staining and Labeling, Histological Techniques, Genetics, Humans, Forensic Medicine, Pathology and Forensic Medicine
Abstract

Cranial vault fractures are of medicolegal interest as they have long-term impacts to someone's health and may contribute to an individual's death. The ability to distinguish antemortem from perimortem fractures and to assess the age of the injury is increasingly dependent on histology. Despite the increasing role of histology in assessing the microanatomy of osseous fractures, there are no methods currently available which account for the nuances and difficulties in creating high-quality histologic slides of cranial vault fractures that allow visualization of cellular features associated with healing bone. The authors present a modified method specific to slide development of human cranial vault fractures derived from the trial-and-error process of creating 730 such slides over a 3-year period which are suitable for the evaluation of the tissues, cells, and nuclei involved in fracture healing. This method adapts and troubleshoots typical histological procedures including sample excision, fixation, decalcification, dehydrating, clearing, embedding, microtomy, and staining, and introduces new procedures including preprocessing photography and cassette placement. By implementing these modifications, the number of poor-quality slides that required a new section to be sent to the histology laboratory was greatly reduced. Proactively implementing this new method into cranial fracture histologic slide development significantly reduces the number of slide rejections due to common issues like folding, chatter, or insufficient staining, saving both time and financial resources for forensic practitioners, researchers, and histotechnologists.

Published
2022
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213. Plastic Laminate Antireflective Coatings for Millimeter-Wave Optics in BICEP Array

Author

Dierickx, M., Ade, P. A. R., Ahmed, Z., Amiri, M, Barkats, D., Basu Thakur, R., Bischoff, C. A., Beck, D. H., Bock, J. J., Buza, V., Cheshire, J. R., Connors, J., Cornelison, J., Crumrine, M., Cukierman, A., Denison, E. V., Duband, L., Eiben, M., Fatigoni, S., Filippini, J. P., Goeckner-Wald, N., Goldfinger, D. C., Grayson, J. A., Grimes, P., Hallinan, G., Halal, G., Halpern, M., Hand, E., Harrison, S. C., Henderson, S. W., Hildebrandt, S. R., Hilton, G. C., Hubmayr, J., Hui, H., Irwin, K. D., Kang, J., Karkare, K. S., Kefeli, S., Kovac, J. M., Kuo, C. L., Lau, K. Y., Leitch, E. M., Lennox, A., Megerian, K. G., Minutolo, L., Moncelsi, L., Nakato, Y., Namikawa, T., Nguyen, H. T., O'Brient, R., Palladino, S., Petroff, M. A., Precup, N., Prouvé, T., Pryke, C., Racine, B., Reintsema, C. D., Santalucia, D., Schillaci, A., Schmitt, B. L., Singari, B., Soliman, A., St. Germaine, T., Steinbach, B., Sudiwala, R. V., Thompson, K. L., Tucker, C., Turner, A. D., Umilta, C., Vergès, C., Vieregg, A. G., Wandui, A., Weber, A. C., Wiebe, D. V., Willmert, J., Wu, W. L. K., Yang, E., Yoon, K. W., Young, E. T., Yu, C. J., Zeng, L., Zhang, C., Zhang, S., Dierickx, M., Ade, P. A. R., Ahmed, Z., Amiri, M, Barkats, D., Basu Thakur, R., Bischoff, C. A., Beck, D. H., Bock, J. J., Buza, V., Cheshire, J. R., Connors, J., Cornelison, J., Crumrine, M., Cukierman, A., Denison, E. V., Duband, L., Eiben, M., Fatigoni, S., Filippini, J. P., Goeckner-Wald, N., Goldfinger, D. C., Grayson, J. A., Grimes, P., Hallinan, G., Halal, G., Halpern, M., Hand, E., Harrison, S. C., Henderson, S. W., Hildebrandt, S. R., Hilton, G. C., Hubmayr, J., Hui, H., Irwin, K. D., Kang, J., Karkare, K. S., Kefeli, S., Kovac, J. M., Kuo, C. L., Lau, K. Y., Leitch, E. M., Lennox, A., Megerian, K. G., Minutolo, L., Moncelsi, L., Nakato, Y., Namikawa, T., Nguyen, H. T., O'Brient, R., Palladino, S., Petroff, M. A., Precup, N., Prouvé, T., Pryke, C., Racine, B., Reintsema, C. D., Santalucia, D., Schillaci, A., Schmitt, B. L., Singari, B., Soliman, A., St. Germaine, T., Steinbach, B., Sudiwala, R. V., Thompson, K. L., Tucker, C., Turner, A. D., Umilta, C., Vergès, C., Vieregg, A. G., Wandui, A., Weber, A. C., Wiebe, D. V., Willmert, J., Wu, W. L. K., Yang, E., Yoon, K. W., Young, E. T., Yu, C. J., Zeng, L., Zhang, C., and Zhang, S.

Abstract

The BICEP/Keck series of experiments target the cosmic microwave background at degree-scale resolution from the South Pole. Over the next few years, the “Stage-3” BICEP Array (BA) telescope will improve the program’s frequency coverage and sensitivity to primordial B-mode polarization by an order of magnitude. The first receiver in the array, BA1, began observing at 30/40 GHz in early 2020. The next two receivers, BA2 and BA3, are currently being assembled and will map the southern sky at frequencies ranging from 95 to 150 GHz. Common to all BA receivers is a refractive, on-axis, cryogenic optical design that focuses microwave radiation onto a focal plane populated with antenna-coupled bolometers. High-performance antireflective coatings up to 760 mm in aperture are needed for each element in the optical chain, and must withstand repeated thermal cycles down to 4 K. Here, we present the design and fabrication of the 30/40 GHz anti-reflection coatings for the recently deployed BA1 receiver, with indices matched to its various polyethylene, nylon and alumina optical components. We describe an epoxy coating technique designed for alumina optics, which achieves better than 80% transmission at room temperature. For polyethylene optical elements, we present a new heat-compression approach that allows low-density polytetrafluoroethylene AR layers to reach sub-percent reflected power. We describe the planned use of these methods for the next BA cryostats, which may inform technological choices for future small-aperture telescopes of the CMB-S4 experiment.

Published
2023

214. Apoptosis-Decellularized Peripheral Nerve Scaffold Allows Regeneration across Nerve Gap.

Author

Wachs, Rebecca A., Wellman, Steven M., Porvasnik, Stacy L., Lakes, Emily H., Cornelison, R. Chase, Song, Young Hye, Allen, Kyle D., and Schmidt, Christine E.

Subjects
NERVOUS system regeneration, NERVE tissue, PERIPHERAL nerve injuries, PERIPHERAL nervous system, NERVE grafting, NERVOUS system injuries, AUTOTRANSPLANTATION
Abstract

Peripheral nerve injury results in loss of motor and sensory function distal to the nerve injury and is often permanent in nerve gaps longer than 5 cm. Autologous nerve grafts (nerve autografts) utilize patients' own nerve tissue from another part of their body to repair the defect and are the gold standard in care. However, there is a limited autologous tissue supply, size mismatch between donor nerve and injured nerve, and morbidity at the site of nerve donation. Decellularized cadaveric nerve tissue alleviates some of these limitations and has demonstrated success clinically. We previously developed an alternative apoptosis-assisted decellularization process for nerve tissue. This new process may result in an ideal scaffold for peripheral nerve regeneration by gently removing cells and antigens while preserving delicate topographical cues. In addition, the apoptosis-assisted process requires less active processing time and is inexpensive. This study examines the utility of apoptosis-decellularized peripheral nerve scaffolds compared to detergent-decellularized peripheral nerve scaffolds and isograft controls in a rat nerve gap model. Results indicate that, at 8 weeks post-injury, apoptosis-decellularized peripheral nerve scaffolds perform similarly to detergent-decellularized and isograft controls in both functional (muscle weight recovery, gait analysis) and histological measures (neurofilament staining, macrophage infiltration). These new apoptosis-decellularized scaffolds hold great promise to provide a less expensive scaffold for nerve injury repair, with the potential to improve nerve regeneration and functional outcomes compared to current detergent-decellularized scaffolds. [ABSTRACT FROM AUTHOR]

Published
2023
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216. Data from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Lu, Karen H., primary, Loose, David S., primary, Yates, Melinda S., primary, Nogueras-Gonzalez, Graciela M., primary, Munsell, Mark F., primary, Chen, Lee-may, primary, Lynch, Henry, primary, Cornelison, Terri, primary, Boyd-Rogers, Stephanie, primary, Rubin, Mary, primary, Daniels, Molly S., primary, Conrad, Peggy, primary, Milbourne, Andrea, primary, Gershenson, David M., primary, and Broaddus, Russell R., primary

Published
2023
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217. Commentary on This Article from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Lu, Karen H., primary, Loose, David S., primary, Yates, Melinda S., primary, Nogueras-Gonzalez, Graciela M., primary, Munsell, Mark F., primary, Chen, Lee-may, primary, Lynch, Henry, primary, Cornelison, Terri, primary, Boyd-Rogers, Stephanie, primary, Rubin, Mary, primary, Daniels, Molly S., primary, Conrad, Peggy, primary, Milbourne, Andrea, primary, Gershenson, David M., primary, and Broaddus, Russell R., primary

Published
2023
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218. Supplementary Table 1 from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Lu, Karen H., primary, Loose, David S., primary, Yates, Melinda S., primary, Nogueras-Gonzalez, Graciela M., primary, Munsell, Mark F., primary, Chen, Lee-may, primary, Lynch, Henry, primary, Cornelison, Terri, primary, Boyd-Rogers, Stephanie, primary, Rubin, Mary, primary, Daniels, Molly S., primary, Conrad, Peggy, primary, Milbourne, Andrea, primary, Gershenson, David M., primary, and Broaddus, Russell R., primary

Published
2023
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219. Data from Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer

Author

Crew, Katherine D., primary, Brown, Powel, primary, Greenlee, Heather, primary, Bevers, Therese B., primary, Arun, Banu, primary, Hudis, Clifford, primary, McArthur, Heather L., primary, Chang, Jenny, primary, Rimawi, Mothaffar, primary, Vornik, Lana, primary, Cornelison, Terri L., primary, Wang, Antai, primary, Hibshoosh, Hanina, primary, Ahmed, Aqeel, primary, Terry, Mary Beth, primary, Santella, Regina M., primary, Lippman, Scott M., primary, and Hershman, Dawn L., primary

Published
2023
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220. Supplementary Figure 1 from Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer

Author

Crew, Katherine D., primary, Brown, Powel, primary, Greenlee, Heather, primary, Bevers, Therese B., primary, Arun, Banu, primary, Hudis, Clifford, primary, McArthur, Heather L., primary, Chang, Jenny, primary, Rimawi, Mothaffar, primary, Vornik, Lana, primary, Cornelison, Terri L., primary, Wang, Antai, primary, Hibshoosh, Hanina, primary, Ahmed, Aqeel, primary, Terry, Mary Beth, primary, Santella, Regina M., primary, Lippman, Scott M., primary, and Hershman, Dawn L., primary

Published
2023
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221. Supplementary Figure Legend from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Lu, Karen H., primary, Loose, David S., primary, Yates, Melinda S., primary, Nogueras-Gonzalez, Graciela M., primary, Munsell, Mark F., primary, Chen, Lee-may, primary, Lynch, Henry, primary, Cornelison, Terri, primary, Boyd-Rogers, Stephanie, primary, Rubin, Mary, primary, Daniels, Molly S., primary, Conrad, Peggy, primary, Milbourne, Andrea, primary, Gershenson, David M., primary, and Broaddus, Russell R., primary

Published
2023
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222. Supplementary Figure 1 from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Lu, Karen H., primary, Loose, David S., primary, Yates, Melinda S., primary, Nogueras-Gonzalez, Graciela M., primary, Munsell, Mark F., primary, Chen, Lee-may, primary, Lynch, Henry, primary, Cornelison, Terri, primary, Boyd-Rogers, Stephanie, primary, Rubin, Mary, primary, Daniels, Molly S., primary, Conrad, Peggy, primary, Milbourne, Andrea, primary, Gershenson, David M., primary, and Broaddus, Russell R., primary

Published
2023
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223. Segmentation and quantitation pipeline for image analysis from Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer

Author

Cornelison, Robert, primary, Dobbin, Zachary C., primary, Katre, Ashwini A., primary, Jeong, Dae Hoon, primary, Zhang, Yinfeng, primary, Chen, Dongquan, primary, Petrova, Yuliya, primary, Llaneza, Danielle C., primary, Steg, Adam D., primary, Parsons, Laura, primary, Schneider, David A., primary, and Landen, Charles N., primary

Published
2023
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224. Data from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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225. Supplementary Figure 2, Part 1 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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226. Supplementary Figure 2, Part 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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227. Supplementary Figure Legend for Figure 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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228. Supplementary Figure 1 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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229. Data from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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230. Supplementary Table 6 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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231. Supplementary Table 3 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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232. Supplementary Table 4 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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233. Supplementary Table 1 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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234. Supplementary Table 2 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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235. Supplementary Table 5 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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236. Supplementary Figure 1 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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237. Supplementary Figure Legend from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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238. BICEP/Keck. XVI. Characterizing Dust Polarization through Correlations with Neutral Hydrogen

Author

Ade, P. A. R., primary, Ahmed, Z., additional, Amiri, M., additional, Barkats, D., additional, Thakur, R. Basu, additional, Bischoff, C. A., additional, Beck, D., additional, Bock, J. J., additional, Boenish, H., additional, Bullock, E., additional, Buza, V., additional, Cheshire, J. R., additional, Clark, S. E., additional, Connors, J., additional, Cornelison, J., additional, Crumrine, M., additional, Cukierman, A., additional, Denison, E. V., additional, Dierickx, M., additional, Duband, L., additional, Eiben, M., additional, Fatigoni, S., additional, Filippini, J. P., additional, Fliescher, S., additional, Giannakopoulos, C., additional, Goeckner-Wald, N., additional, Goldfinger, D. C., additional, Grayson, J., additional, Grimes, P., additional, Hall, G., additional, Halal, G., additional, Halpern, M., additional, Hand, E., additional, Harrison, S., additional, Henderson, S., additional, Hildebrandt, S. R., additional, Hubmayr, J., additional, Hui, H., additional, Irwin, K. D., additional, Kang, J., additional, Karkare, K. S., additional, Karpel, E., additional, Kefeli, S., additional, Kernasovskiy, S. A., additional, Kovac, J. M., additional, Kuo, C. L., additional, Lau, K., additional, Leitch, E. M., additional, Lennox, A., additional, Megerian, K. G., additional, Minutolo, L., additional, Moncelsi, L., additional, Nakato, Y., additional, Namikawa, T., additional, Nguyen, H. T., additional, O’Brient, R., additional, IV, R. W. Ogburn, additional, Palladino, S., additional, Petroff, M. A., additional, Prouve, T., additional, Pryke, C., additional, Racine, B., additional, Reintsema, C. D., additional, Richter, S., additional, Schillaci, A., additional, Schwarz, R., additional, Schmitt, B. L., additional, Sheehy, C. D., additional, Singari, B., additional, Soliman, A., additional, Germaine, T. St., additional, Steinbach, B., additional, Sudiwala, R. V., additional, Teply, G. P., additional, Thompson, K. L., additional, Tolan, J. E., additional, Tucker, C., additional, Turner, A. D., additional, Umiltà, C., additional, Vergès, C., additional, Vieregg, A. G., additional, Wandui, A., additional, Weber, A. C., additional, Wiebe, D. V., additional, Willmert, J., additional, Wong, C. L., additional, Wu, W. L. K., additional, Yang, H., additional, Yoon, K. W., additional, Young, E., additional, Yu, C., additional, Zeng, L., additional, Zhang, C., additional, and Zhang, S., additional

Published
2023
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239. Abstract P4-08-18: Engineered Toxin Bodies Specific for TROP2 Positive Cancers

Author

Cornelison, Garrett L., primary, Pedraza, Ileana, additional, Garrison, Kendra, additional, Kapeel, Elizabeth M., additional, Pletka, Channing, additional, Khan, Abdul, additional, Momb, Jessica, additional, Martin, Rebecca, additional, Bartos, Adam, additional, Dekker, Joseph D., additional, Zhao, Jay, additional, Majercak, John, additional, and Robinson, Garrett L., additional

Published
2023
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241. Outcome of Patients with Immunoglobulin Light-Chain Amyloidosis with Lung, Liver, Gastrointestinal, Neurologic, and Soft Tissue Involvement after Autologous Hematopoietic Stem Cell Transplantation

Author

Afrough, Aimaz, Saliba, Rima M., Hamdi, Amir, El Fakih, Riad, Varma, Ankur, Dinh, Yvonne T., Rondon, Gabriela, Cornelison, A. Megan, Shah, Nina D., Bashir, Qaiser, Shah, Jatin J., Hosing, Chitra, Popat, Uday, Orlowski, Robert Z., Champlin, Richard E., Parmar, Simrit, and Qazilbash, Muzaffar H.

Published
2015
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242. Brain Cancer Cell-Derived Matrices and Effects on Astrocyte Migration

Author

Rebecca Louisthelmy, Brycen M. Burke, and R. Chase Cornelison

Subjects
Histology, Anatomy
Abstract

Cell-derived matrices are useful tools for studying the extracellular matrix (ECM) of different cell types and testing the effects on cell migration or wound repair. These matrices typically are generated using extended culture with ascorbic acid to boost ECM production. Applying this technique to cancer cell cultures could advance the study of cancer ECM and its effects on recruitment and training of the tumor microenvironment, but ascorbic acid is potently cytotoxic to cancer cells. Macromolecular crowding agents can also be added to increase matrix deposition based on the excluded volume principle. We report the use of macromolecular crowding (MMC) alone as an effective strategy to generate brain cancer cell-derived matrices for downstream analyses and cell migration studies. We cultured the mouse glioblastoma cell line GL261 for 1 week in the presence of three previously-reported MMC agents (carrageenan, Ficoll 70/400, and hyaluronic acid). We measured the resulting deposition of collagens and sulfated glycosaminoglycans using quantitative assays, as well as other matrix components by immunostaining. Both carrageenan and Ficoll promoted significantly more accumulation of total collagen content, sulfated glycosaminoglycan content, and fibronectin staining. Only Ficoll, however, also demonstrated a significant increase in collagen I staining. The results were more variable in 3D spheroid culture. We focused on Ficoll MMC matrices, which were isolated using the small molecule Raptinal to induce cancer cell apoptosis and matrix decellularization. The cancer cell-derived matrix promoted significantly faster migration of human astrocytes in a scratch wound assay, which may be explained by focal adhesion morphology and an increase in cellular metabolic activity. Ultimately, these data show MMC culture is a useful technique to generate cancer cell-derived matrices and study the effects on stromal cell migration related to wound repair.

Published
2022
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243. Data from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Russell R. Broaddus, David M. Gershenson, Andrea Milbourne, Peggy Conrad, Molly S. Daniels, Mary Rubin, Stephanie Boyd-Rogers, Terri Cornelison, Henry Lynch, Lee-may Chen, Mark F. Munsell, Graciela M. Nogueras-Gonzalez, Melinda S. Yates, David S. Loose, and Karen H. Lu

Abstract

Women with Lynch syndrome have a 40% to 60% lifetime risk for developing endometrial cancer, a cancer associated with estrogen imbalance. The molecular basis for endometrial-specific tumorigenesis is unclear. Progestins inhibit estrogen-driven proliferation, and epidemiologic studies have shown that progestin-containing oral contraceptives (OCP) reduce the risk of endometrial cancer by 50% in women at general population risk. It is unknown whether they are effective in women with Lynch syndrome. Asymptomatic women ages 25 to 50 with Lynch syndrome were randomized to receive the progestin compounds Depo-Provera (depo-MPA) or OCP for three months. An endometrial biopsy and transvaginal ultrasound were conducted before and after treatment. Endometrial proliferation was evaluated as the primary endpoint. Histology and a panel of surrogate endpoint biomarkers were evaluated for each endometrial biopsy as secondary endpoints. A total of 51 women were enrolled, and 46 completed treatment. Two of the 51 women had complex hyperplasia with atypia at the baseline endometrial biopsy and were excluded from the study. Overall, both depo-MPA and OCP induced a dramatic decrease in endometrial epithelial proliferation and microscopic changes in the endometrium characteristic of progestin action. Transvaginal ultrasound measurement of endometrial stripe was not a useful measure of endometrial response or baseline hyperplasia. These results show that women with Lynch syndrome do show an endometrial response to short-term exogenous progestins, suggesting that OCP and depo-MPA may be reasonable chemopreventive agents in this high-risk patient population. Cancer Prev Res; 6(8); 774–81. ©2013 AACR.

Published
2023
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244. Supplementary Figure Legend from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Russell R. Broaddus, David M. Gershenson, Andrea Milbourne, Peggy Conrad, Molly S. Daniels, Mary Rubin, Stephanie Boyd-Rogers, Terri Cornelison, Henry Lynch, Lee-may Chen, Mark F. Munsell, Graciela M. Nogueras-Gonzalez, Melinda S. Yates, David S. Loose, and Karen H. Lu

Abstract

PDF file - 42K

Published
2023
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245. Supplementary Figure 1 from Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer

Author

Dawn L. Hershman, Scott M. Lippman, Regina M. Santella, Mary Beth Terry, Aqeel Ahmed, Hanina Hibshoosh, Antai Wang, Terri L. Cornelison, Lana Vornik, Mothaffar Rimawi, Jenny Chang, Heather L. McArthur, Clifford Hudis, Banu Arun, Therese B. Bevers, Heather Greenlee, Powel Brown, and Katherine D. Crew

Abstract

PDF file, 117K, Supplementary figure with graphical representations of biomarker data (total tea polyphenols, Ki-67, ER, mammographic density).

Published
2023
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246. Supplementary Figure 1 from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Russell R. Broaddus, David M. Gershenson, Andrea Milbourne, Peggy Conrad, Molly S. Daniels, Mary Rubin, Stephanie Boyd-Rogers, Terri Cornelison, Henry Lynch, Lee-may Chen, Mark F. Munsell, Graciela M. Nogueras-Gonzalez, Melinda S. Yates, David S. Loose, and Karen H. Lu

Abstract

PDF file - 9245K, Supplementary Figure S1. Baseline endometrial abnormalities detected in the pre-treatment biopsies from these high-risk women.

Published
2023
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247. Commentary on This Article from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Russell R. Broaddus, David M. Gershenson, Andrea Milbourne, Peggy Conrad, Molly S. Daniels, Mary Rubin, Stephanie Boyd-Rogers, Terri Cornelison, Henry Lynch, Lee-may Chen, Mark F. Munsell, Graciela M. Nogueras-Gonzalez, Melinda S. Yates, David S. Loose, and Karen H. Lu

Abstract

Commentary on This Article from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Published
2023
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248. Supplementary Table 1 from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Author

Russell R. Broaddus, David M. Gershenson, Andrea Milbourne, Peggy Conrad, Molly S. Daniels, Mary Rubin, Stephanie Boyd-Rogers, Terri Cornelison, Henry Lynch, Lee-may Chen, Mark F. Munsell, Graciela M. Nogueras-Gonzalez, Melinda S. Yates, David S. Loose, and Karen H. Lu

Abstract

XLSX file - 34K, Supplementary Table S1. Probes and primers for real-time PCR biomarker assays.

Published
2023
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249. Supplementary Figure 2, Part 1 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Mark E. Sherman, Paul D.P. Pharoah, Jonine D. Figueroa, Petra Lenz, Sean Davis, Paul Meltzer, Sarah L. Anzick, Robert Cornelison, Xiaohong R. Yang, Stephen M. Hewitt, William J. Howat, Máire A. Duggan, Ruth M. Pfeiffer, Montserrat Garcia-Closas, and Kelly L. Bolton

Abstract

Supplementary Figure 2, Part 1 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Published
2023
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250. Segmentation and quantitation pipeline for image analysis from Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer

Author

Charles N. Landen, David A. Schneider, Laura Parsons, Adam D. Steg, Danielle C. Llaneza, Yuliya Petrova, Dongquan Chen, Yinfeng Zhang, Dae Hoon Jeong, Ashwini A. Katre, Zachary C. Dobbin, and Robert Cornelison

Abstract

Explanation and example analysis pipeline used to quantitate changes in cell size and other parameters. Supplemental Figure 1: (A) Sample images of immunofluorescence of F-actin (red) and DAPI (blue) before and after IC50treatment with CX-5461. Images were taken at random at 200x magnification. Thresholding was performed to identify DAPI stained nuclei using the Mixture of Gaussian (MoG) technique to bin pixels into foreground and background classes. Cytoplasm, marked by F-actin, was segmented using the watershed technique after Sobel transformation followed by Otsu thresholding. All image segmentation and quantitation was performed by CellProfiler. (B) Summary quantitation in representative images of changes to segmented cells' parameters before and after treatment.

Published
2023
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