9,968 results on '"A. Zecca"'
Search Results
202. Major depressive disorder subtypes and depression symptoms in multiple sclerosis: What is different compared to the general population?
- Author
-
Rodgers, Stephanie, Calabrese, Pasquale, Ajdacic-Gross, Vladeta, Steinemann, Nina, Kaufmann, Marco, Salmen, Anke, Manjaly, Zina-Mary, Kesselring, Jürg, Kamm, Christian P., Kuhle, Jens, Chan, Andrew, Gobbi, Claudio, Zecca, Chiara, Müller, Stefanie, and von Wyl, Viktor more...
- Published
- 2021
- Full Text
- View/download PDF
203. The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects
- Author
-
Cupaioli, Francesca A., Zucca, Fabio A., Caporale, Cinzia, Lesch, Klaus-Peter, Passamonti, Luca, and Zecca, Luigi
- Published
- 2021
- Full Text
- View/download PDF
204. The Real-World Experiences of Persons With Multiple Sclerosis During the First COVID-19 Lockdown: Application of Natural Language Processing
- Author
-
Deborah Chiavi, Christina Haag, Andrew Chan, Christian Philipp Kamm, Chloé Sieber, Mina Stanikić, Stephanie Rodgers, Caroline Pot, Jürg Kesselring, Anke Salmen, Irene Rapold, Pasquale Calabrese, Zina-Mary Manjaly, Claudio Gobbi, Chiara Zecca, Sebastian Walther, Katharina Stegmayer, Robert Hoepner, Milo Puhan, and Viktor von Wyl more...
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundThe increasing availability of “real-world” data in the form of written text holds promise for deepening our understanding of societal and health-related challenges. Textual data constitute a rich source of information, allowing the capture of lived experiences through a broad range of different sources of information (eg, content and emotional tone). Interviews are the “gold standard” for gaining qualitative insights into individual experiences and perspectives. However, conducting interviews on a large scale is not always feasible, and standardized quantitative assessment suitable for large-scale application may miss important information. Surveys that include open-text assessments can combine the advantages of both methods and are well suited for the application of natural language processing (NLP) methods. While innovations in NLP have made large-scale text analysis more accessible, the analysis of real-world textual data is still complex and requires several consecutive steps. ObjectiveWe developed and subsequently examined the utility and scientific value of an NLP pipeline for extracting real-world experiences from textual data to provide guidance for applied researchers. MethodsWe applied the NLP pipeline to large-scale textual data collected by the Swiss Multiple Sclerosis (MS) registry. Such textual data constitute an ideal use case for the study of real-world text data. Specifically, we examined 639 text reports on the experienced impact of the first COVID-19 lockdown from the perspectives of persons with MS. The pipeline has been implemented in Python and complemented by analyses of the “Linguistic Inquiry and Word Count” software. It consists of the following 5 interconnected analysis steps: (1) text preprocessing; (2) sentiment analysis; (3) descriptive text analysis; (4) unsupervised learning–topic modeling; and (5) results interpretation and validation. ResultsA topic modeling analysis identified the following 4 distinct groups based on the topics participants were mainly concerned with: “contacts/communication;” “social environment;” “work;” and “errands/daily routines.” Notably, the sentiment analysis revealed that the “contacts/communication” group was characterized by a pronounced negative emotional tone underlying the text reports. This observed heterogeneity in emotional tonality underlying the reported experiences of the first COVID-19–related lockdown is likely to reflect differences in emotional burden, individual circumstances, and ways of coping with the pandemic, which is in line with previous research on this matter. ConclusionsThis study illustrates the timely and efficient applicability of an NLP pipeline and thereby serves as a precedent for applied researchers. Our study thereby contributes to both the dissemination of NLP techniques in applied health sciences and the identification of previously unknown experiences and burdens of persons with MS during the pandemic, which may be relevant for future treatment. more...
- Published
- 2022
- Full Text
- View/download PDF
205. Georges Balandier, La situazione coloniale e altri saggi, a cura di Alice Bellagamba, Rita Finco, traduzione di Alice Bellagamba, Rita Finco, Milano, Meltemi, 2022, pp. 156
- Author
-
Raúl Zecca Castel
- Subjects
Ethnology. Social and cultural anthropology ,GN301-674 - Abstract
Recensione di Georges Balandier, La situazione coloniale e altri saggi, a cura di Alice Bellagamba, Rita Finco, traduzione di Alice Bellagamba, Rita Finco, Milano, Meltemi, 2022, pp. 156.
- Published
- 2022
- Full Text
- View/download PDF
206. Longitudinal Postvaccine SARS-CoV-2 Immunoglobulin G Titers, Memory B-Cell Responses, and Risk of COVID-19 in Multiple Sclerosis Over 1 Year
- Author
-
Disanto, Giulio, Galante, Alice, Cantuʼ, Marco, Sacco, Rosaria, Mele, Federico, Eisler, Jennifer Jessica, Keller, Franco, Bernasconi, Enos, Sallusto, Federica, Zecca, Chiara, and Gobbi, Claudio
- Published
- 2023
- Full Text
- View/download PDF
207. Outpatient palliative care referral system (PCRS) for patients with advanced cancer: an impact evaluation protocol
- Author
-
Filippo de Braud, Alessandra Raimondi, Salvatore Provenzano, Marta Brambilla, Cinzia Brunelli, Monica Niger, Ernesto Zecca, Paola Bracchi, Silvia Lo Dico, Mariangela Caputo, Alessandra Pigni, Viviana Fusetti, Antonino Tallarita, Cristiana Bergamini, Pierangela Sepe, Sara Alfieri, Gabriele Tinè, and Augusto Tommaso Caraceni more...
- Subjects
Medicine - Abstract
Introduction Early palliative care (PC) in the clinical pathway of advanced cancer patients improves symptom control, quality of life and has a positive impact on overall quality of care. At present, standardised criteria for appropriate referral for early PC in oncology care are lacking. The aim of this project is to develop a set of standardised referral criteria and procedures to implement appropriate early PC for advanced cancer patients (the palliative care referral system, PCRS) and test its impact on user perception of quality of care received, on patient quality of life and on the use of healthcare resources.Setting Selected oncology clinics and PC outpatient clinic.Methods and analysis A scoping literature review and an expert consultation through a nominal group technique will be used to revise existing referral tools and to develop a new one, the PCRS. 25 patients will be enrolled in a pilot study to assess feasibility of the implementation of PCRS; 10 interviews with patients and healthcare professionals will be carried out to evaluate applicability.A pretest–post-test quasiexperimental study involving 150 patients before implementation of the PCRS and 150 patients after implementation will be carried out.Patient satisfaction with care received, quality of life and use of resources, and caregiver satisfaction with care will also be assessed to explore the impact of the intervention.Ethics and dissemination Ethical approval for the study has been granted by the Institutional Review board of the Fondazione IRCCS Istituto Nazionale Tumori; approval reference INT201/19.Results will be disseminated through open access publications and through scientific communication presented at national and international conferences.Trial registration number NCT04936568. more...
- Published
- 2022
- Full Text
- View/download PDF
208. Electronic Health Diary Campaigns to Complement Longitudinal Assessments in Persons With Multiple Sclerosis: Nested Observational Study
- Author
-
Chloé Sieber, Deborah Chiavi, Christina Haag, Marco Kaufmann, Andrea B Horn, Holger Dressel, Chiara Zecca, Pasquale Calabrese, Caroline Pot, Christian Philipp Kamm, and Viktor von Wyl
- Subjects
Information technology ,T58.5-58.64 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundElectronic health diaries hold promise in complementing standardized surveys in prospective health studies but are fraught with numerous methodological challenges. ObjectiveThe study aimed to investigate participant characteristics and other factors associated with response to an electronic health diary campaign in persons with multiple sclerosis, identify recurrent topics in free-text diary entries, and assess the added value of structured diary entries with regard to current symptoms and medication intake when compared with survey-collected information. MethodsData were collected by the Swiss Multiple Sclerosis Registry during a nested electronic health diary campaign and during a regular semiannual Swiss Multiple Sclerosis Registry follow-up survey serving as comparator. The characteristics of campaign participants were descriptively compared with those of nonparticipants. Diary content was analyzed using the Linguistic Inquiry and Word Count 2015 software (Pennebaker Conglomerates, Inc) and descriptive keyword analyses. The similarities between structured diary data and follow-up survey data on health-related quality of life, symptoms, and medication intake were examined using the Jaccard index. ResultsCampaign participants (n=134; diary entries: n=815) were more often women, were not working full time, did not have a higher education degree, had a more advanced gait impairment, and were on average 5 years older (median age 52.5, IQR 43.25-59.75 years) than eligible nonparticipants (median age 47, IQR 38-55 years; n=524). Diary free-text entries (n=632; participants: n=100) most often contained references to the following standard Linguistic Inquiry and Word Count word categories: negative emotion (193/632, 30.5%), body parts or body functioning (191/632, 30.2%), health (94/632, 14.9%), or work (67/632, 10.6%). Analogously, the most frequently mentioned keywords (diary entries: n=526; participants: n=93) were “good,” “day,” and “work.” Similarities between diary data and follow-up survey data, collected 14 months apart (median), were high for health-related quality of life and stable for slow-changing symptoms such as fatigue or gait disorder. Similarities were also comparatively high for drugs requiring a regular application, including interferon beta-1a (Avonex) and glatiramer acetate (Copaxone), and for modern oral therapies such as fingolimod (Gilenya) and teriflunomide (Aubagio). ConclusionsDiary campaign participation seemed dependent on time availability and symptom burden and was enhanced by reminder emails. Electronic health diaries are a meaningful complement to regular structured surveys and can provide more detailed information regarding medication use and symptoms. However, they should ideally be embedded into promotional activities or tied to concrete research study tasks to enhance regular and long-term participation. more...
- Published
- 2022
- Full Text
- View/download PDF
209. On the existence and blow-up of solutions for a mean field equation with variable intensities
- Author
-
Ricciardi, Tonia, Takahashi, Ryo, Zecca, Gabriella, and Zhang, Xiao
- Subjects
Mathematics - Analysis of PDEs - Abstract
We study an elliptic problem with exponential nonlinearities describing the statistical mechanics equilibrium of point vortices with variable intensities. For suitable values of the physical parameters we exclude the existence of blow-up points on the boundary, we prove a mass quantization property and we apply our analysis to the construction of minimax solutions. more...
- Published
- 2015
210. Association of Immune Thrombocytopenia and Celiac Disease in Children: A Retrospective Case Control Study
- Author
-
Angela Guarina, Maddalena Marinoni, Giuseppe Lassandro, Paola Saracco, Silverio Perrotta, Elena Facchini, Lucia Dora Notarangelo, Giovanna Russo, Paola Giordano, Francesca Romano, Giuseppe Bertoni, Chiara Gorio, Gabriela Boscarol, Milena Motta, Marco Spinelli, Angelica Barone, Marco Zecca, Francesca Compagno, Saverio Ladogana, Angela Maggio, Maurizio Miano, Gianluca DellOrso, Elena Chiocca, Ilaria Fotzi, Angela Petrone, Assunta Tornesello, Irene D'Alba, Silvia Salvatore, Maddalena Casale, Giuseppe Puccio, Ugo Ramenghi, and Piero Farruggia more...
- Subjects
celiac ,children ,immune ,thrombocytopenia ,pediatric ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Objective: The association between celiac disease (CD) and immune thrombocytopenia (ITP) is still uncertain. The aim of this study was to characterize the coexistence of these two diseases in Italian children. Materials and Methods: This is a retrospective multicenter study investigating the occurrence of CD in 28 children with ITP diagnosed from January 1, 2000, to December 31, 2019. Results: The first diagnosis was ITP in 57.1% and CD in 32.1% of patients. In 3 patients (10.7%), the two diagnoses were simultaneous. All the potential and silent cases of CD in our cohort were diagnosed in the groups of 'ITP first' and 'simultaneous diagnosis'. In all children ITP was mild, and in 2 out of 8 not recovered from ITP at the time of CD diagnosis a normalization of platelet counts (>100,000/μL) occurred 3 and 5 months after starting a gluten-free diet, respectively. Conclusion: We think that screening for CD should be considered in children with ITP regardless of the presence of gastrointestinal symptoms. Furthermore, some patients may recover from ITP after starting a gluten-free diet. more...
- Published
- 2021
- Full Text
- View/download PDF
211. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
- Author
-
Adeleye, Adelani, Alba, Camille, Bacikova, Dagmar, Hupalo, Daniel N., Martinez, Elisa McGrath, Pollard, Harvey B., Sukumar, Gauthaman, Soltis, Anthony R., Tuck, Meila, Zhang, Xijun, Wilkerson, Matthew D., Smith, Bradley N., Ticozzi, Nicola, Fallini, Claudia, Gkazi, Athina Soragia, Topp, Simon D., Kost, Jason, Scotter, Emma L., Kenna, Kevin P., Miller, Jack W., Tiloca, Cinzia, Vance, Caroline, Danielson, Eric W., Troakes, Claire, Colombrita, Claudia, Al-Sarraj, Safa, Lewis, Elizabeth A., King, Andrew, Calini, Daniela, Pensato, Viviana, Castellotti, Barbara, de Belleroche, Jacqueline, Baas, Frank, ten Asbroek, Anneloor L.M.A., Sapp, Peter C., McKenna-Yasek, Diane, McLaughlin, Russell L., Polak, Meraida, Asress, Seneshaw, Esteban-Pérez, Jesús, Muñoz-Blanco, José Luis, Stevic, Zorica, D’Alfonso, Sandra, Mazzini, Letizia, Comi, Giacomo P., Del Bo, Roberto, Ceroni, Mauro, Gagliardi, Stella, Querin, Giorgia, Bertolin, Cinzia, van Rheenen, Wouter, Diekstra, Frank P., Rademakers, Rosa, van Blitterswijk, Marka, Boylan, Kevin B., Lauria, Giuseppe, Duga, Stefano, Corti, Stefania, Cereda, Cristina, Corrado, Lucia, Sorarù, Gianni, Williams, Kelly L., Nicholson, Garth A., Blair, Ian P., Leblond-Manry, Claire, Rouleau, Guy A., Hardiman, Orla, Morrison, Karen E., Veldink, Jan H., van den Berg, Leonard H., Al-Chalabi, Ammar, Pall, Hardev, Shaw, Pamela J., Turner, Martin R., Talbot, Kevin, Taroni, Franco, García-Redondo, Alberto, Wu, Zheyang, Gellera, Cinzia, Ratti, Antonia, Brown, Robert H., Jr., Shaw, Christopher E., Ambrose, John C., Arumugam, Prabhu, Baple, Emma L., Bleda, Marta, Boardman-Pretty, Freya, Boissiere, Jeanne M., Boustred, Christopher R., Brittain, H., Caulfield, Mark J., Chan, Georgia C., Craig, Clare E.H., Daugherty, Louise C., de Burca, Anna, Devereau, Andrew, Elgar, Greg, Foulger, Rebecca E., Fowler, Tom, Furió-Tarí, Pedro, Hackett, Joanne M., Halai, Dina, Hamblin, Angela, Henderson, Shirley, Holman, James E., Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Lahnstein, Lea, Lawson, Kay, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, Mason, Joanne, McDonagh, Ellen M., Moutsianas, Loukas, Mueller, Michael, Murugaesu, Nirupa, Need, Anna C., Odhams, Chris A., Patch, Christine, Perez-Gil, Daniel, Polychronopoulos, Dimitris, Pullinger, John, Rahim, Tahrima, Rendon, Augusto, Riesgo-Ferreiro, Pablo, Rogers, Tim, Savage, Kevin, Sawant, Kushmita, Scott, Richard H., Siddiq, Afshan, Sieghart, Alexander, Smedley, Damian, Smith, Katherine R., Sosinsky, Alona, Spooner, William, Stevens, Helen E., Stuckey, Alexander, Sultana, Razvan, Thomas, Ellen R.A., Thompson, Simon R., Tregidgo, Carolyn, Walsh, Emma, Watters, Sarah A., Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Zarowiecki, Magdalena, Arepalli, Sampath, Auluck, Pavan, Baloh, Robert H., Bowser, Robert, Brice, Alexis, Broach, James, Camu, William, Chiò, Adriano, Cooper-Knock, John, Corcia, Philippe, Drepper, Carsten, Drory, Vivian E., Dunckley, Travis L., Faghri, Faraz, Farren, Jennifer, Feldman, Eva, Floeter, Mary Kay, Fratta, Pietro, Gerhard, Glenn, Gibson, Summer B., Goutman, Stephen A., Heiman-Patterson, Terry D., Hernandez, Dena G., Hoover, Ben, Jansson, Lilja, Kamel, Freya, Kirby, Janine, Kowall, Neil W., Laaksovirta, Hannu, Landi, Francesco, Le Ber, Isabelle, Lumbroso, Serge, MacGowan, Daniel JL., Maragakis, Nicholas J., Mora, Gabriele, Mouzat, Kevin, Myllykangas, Liisa, Nalls, Mike A., Orrell, Richard W., Ostrow, Lyle W., Pamphlett, Roger, Pioro, Erik, Pulst, Stefan M., Ravits, John M., Renton, Alan E., Robberecht, Wim, Robey, Ian, Rogaeva, Ekaterina, Rothstein, Jeffrey D., Sendtner, Michael, Sidle, Katie C., Simmons, Zachary, Stone, David J., Tienari, Pentti J., Trojanowski, John Q., Troncoso, Juan C., Valori, Miko, Van Damme, Philip, Van Den Bosch, Ludo, Zinman, Lorne, Albani, Diego, Borroni, Barbara, Padovani, Alessandro, Bruni, Amalia, Clarimon, Jordi, Dols-Icardo, Oriol, Illán-Gala, Ignacio, Lleó, Alberto, Danek, Adrian, Galimberti, Daniela, Scarpini, Elio, Serpente, Maria, Graff, Caroline, Chiang, Huei-Hsin, Khoshnood, Behzad, Öijerstedt, Linn, Morris, Christopher M., Nacmias, Benedetta, Sorbi, Sandro, Nielsen, Jorgen E., Hjermind, Lynne E., Novelli, Valeria, Puca, Annibale A., Pastor, Pau, Alvarez, Ignacio, Diez-Fairen, Monica, Aguilar, Miquel, Perneczky, Robert, Diehl-Schimd, Janine, Rossi, Mina, Ruiz, Agustin, Boada, Mercè, Hernández, Isabel, Moreno-Grau, Sonia, Schlachetzki, Johannes C., Aarsland, Dag, Albert, Marilyn S., Attems, Johannes, Barrett, Matthew J., Beach, Thomas G., Bekris, Lynn M., Bennett, David A., Besser, Lilah M., Bigio, Eileen H., Black, Sandra E., Boeve, Bradley F., Bohannan, Ryan C., Brett, Francesca, Brunetti, Maura, Caraway, Chad A., Palma, Jose-Alberto, Calvo, Andrea, Canosa, Antonio, Dickson, Dennis, Duyckaerts, Charles, Faber, Kelley, Ferman, Tanis, Flanagan, Margaret E., Floris, Gianluca, Foroud, Tatiana M., Fortea, Juan, Gan-Or, Ziv, Gentleman, Steve, Ghetti, Bernardino, Gibbs, Jesse Raphael, Goate, Alison, Goldstein, David, González-Aramburu, Isabel, Graff-Radford, Neill R., Hodges, Angela K., Hu, Heng-Chen, Hupalo, Daniel, Infante, Jon, Iranzo, Alex, Kaiser, Scott M., Kaufmann, Horacio, Keith, Julia, Kim, Ronald C., Klein, Gregory, Krüger, Rejko, Kukull, Walter, Kuzma, Amanda, Lage, Carmen, Lesage, Suzanne, Leverenz, James B., Logroscino, Giancarlo, Lopez, Grisel, Love, Seth, Mao, Qinwen, Marti, Maria Jose, Martinez-McGrath, Elisa, Masellis, Mario, Masliah, Eliezer, May, Patrick, McKeith, Ian, Mesulam, Marek-Marsel, Monuki, Edwin S., Newell, Kathy L., Norcliffe-Kaufmann, Lucy, Palmer, Laura, Perkins, Matthew, Pletnikova, Olga, Molina-Porcel, Laura, Reynolds, Regina H., Rodríguez-Rodríguez, Eloy, Rohrer, Jonathan D., Sanchez-Juan, Pascual, Scherzer, Clemens R., Serrano, Geidy E., Shakkottai, Vikram, Sidransky, Ellen, Tayebi, Nahid, Thomas, Alan J., Tilley, Bension S., Walton, Ronald L., Woltjer, Randy, Wszolek, Zbigniew K., Xiromerisiou, Georgia, Zecca, Chiara, Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Arcila-Londono, Ximena, Lee, Edward B., Shneider, Neil A., Fraenkel, Ernest, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Harms, Matt, Aronica, Eleonora, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Amar, Khaled, Archibald, Neil, Bandmann, Oliver, Capps, Erica, Church, Alistair, Coebergh, Jan, Costantini, Alyssa, Critchley, Peter, Ghosh, Boyd CP., Hu, Michele T.M., Kobylecki, Christopher, Leigh, P. Nigel, Mann, Carl, Massey, Luke A., Morris, Huw R., Nath, Uma, Pavese, Nicola, Paviour, Dominic, Sharma, Jagdish, Vaughan, Jenny, Dewan, Ramita, Chia, Ruth, Ding, Jinhui, Hickman, Richard A., Stein, Thor D., Abramzon, Yevgeniya, Ahmed, Sarah, Sabir, Marya S., Portley, Makayla K., Tucci, Arianna, Ibáñez, Kristina, Shankaracharya, F.N.U., Keagle, Pamela, Rossi, Giacomina, Caroppo, Paola, Tagliavini, Fabrizio, Waldo, Maria L., Johansson, Per M., Nilsson, Christer F., Rowe, James B., Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Jabbari, Edwin, Viollet, Coralie, Glass, Jonathan D., Singleton, Andrew B., Silani, Vincenzo, Ross, Owen A., Ryten, Mina, Torkamani, Ali, Tanaka, Toshiko, Ferrucci, Luigi, Resnick, Susan M., Pickering-Brown, Stuart, Brady, Christopher B., Kowal, Neil, Hardy, John A., Van Deerlin, Vivianna, Vonsattel, Jean Paul, Harms, Matthew B., Ferrari, Raffaele, Landers, John E., Gibbs, J. Raphael, Dalgard, Clifton L., Scholz, Sonja W., and Traynor, Bryan J. more...
- Published
- 2021
- Full Text
- View/download PDF
212. Physiotherapy use and access-barriers in persons with multiple sclerosis: A cross-sectional analysis
- Author
-
Fortunato, Remo, van der Maas, Nico Arie, Biland-Thommen, Ursula, Kaufmann, Marco, Sieber, Chloé, Kamm, Christian P, Zecca, Chiara, Gobbi, Claudio, Chan, Andrew, Calabrese, Pasquale, Kesselring, Jürg, and von Wyl, Viktor more...
- Published
- 2021
- Full Text
- View/download PDF
213. Metabolic regulation of the HBV-specific T cell function
- Author
-
Barili, Valeria, Boni, Carolina, Rossi, Marzia, Vecchi, Andrea, Zecca, Alessandra, Penna, Amalia, Missale, Gabriele, Ferrari, Carlo, and Fisicaro, Paola
- Published
- 2021
- Full Text
- View/download PDF
214. Technology’s Challenge to Regulators
- Author
-
Tabb, Larry, primary, Adam, John, additional, Berman, Gregg, additional, Fortunato, Anthony, additional, Wood, Greg, additional, and Zecca, John, additional
- Published
- 2022
- Full Text
- View/download PDF
215. La Vie et passion de Notre Seigneur Jésus-Christ (The Life and Passion of Jesus Christ)
- Author
-
Zecca, Ferdinand, primary
- Published
- 2022
- Full Text
- View/download PDF
216. Perceptions of Socially Assistive Robots Among Community-Dwelling Older Adults
- Author
-
Camp, Nicola, primary, Di Nuovo, Alessandro, additional, Hunter, Kirsty, additional, Johnston, Julie, additional, Zecca, Massimiliano, additional, Lewis, Martin, additional, and Magistro, Daniele, additional more...
- Published
- 2022
- Full Text
- View/download PDF
217. In Vitro Investigation of the Mechanical Properties of Blended 3D-Printing Resins for Orthodontic Aligners: A Comparison between Commercial Resin and Nickel-Titanium Wire
- Author
-
Piero Antonio Zecca, Salvatore Bocchieri, Marina Borgese, Carolina Dolci, Alessandra Campobasso, Giovanni Battista, Alberto Caprioglio, and Mario Raspanti
- Subjects
3D-printing resin ,mechanical properties ,orthodontic aligners ,three-point bending test ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
This scientific article investigates the mechanical properties of a novel three-dimensional-printing resin specifically designed for orthodontic aligners and compares it to other commonly used resins. The resin was made by blending two commercially available and certified resins to produce aligners with improved mechanical properties compared to each separate resin. The study examined the effect of the addition of NextDent Ortho Rigid resin on the mechanical properties of the specimens, more specifically analyzing the relationship between the amount of the added rigid resin and the mechanical properties of the specimens. The mechanical properties of the specimens and the nickel-titanium wires were analyzed using a three-point bending test setup. The results showed no statistically significant differences within the different groups of specimens. The study provides valuable insights into the potential of the resin to meet the mechanical demands of orthodontic treatments. It will contribute to the advancement of personalized orthodontic care through three-dimensional-printing technology. Blending commercially available and certified resins enables orthodontic practitioners to select the most suitable resin for each case, providing better outcomes for patients and increasing the efficiency of the treatment process. Further research and evaluation would be required to determine the suitability of the blended resin for orthodontic treatments. more...
- Published
- 2023
- Full Text
- View/download PDF
218. Patient Blood Management after Hematopoietic Stem Cell Transplantation in a Pediatric Setting: Starting Low and Going Lower
- Author
-
Claudia Del Fante, Cristina Mortellaro, Santina Recupero, Giovanna Giorgiani, Annalisa Agostini, Arianna Panigari, Cesare Perotti, and Marco Zecca
- Subjects
patient blood management ,hematopoietic stem cell transplantation ,transfusions ,children ,Medicine (General) ,R5-920 - Abstract
Despite the substantial transfusion requirements, there are few studies on the optimal transfusion strategy in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Our study aimed to retrospectively analyze red blood cell (RBC) and platelet (PLT) transfusion practices during the first 100 days after HSCT at the pediatric hematology/oncology unit of our hospital between 2016 and 2019, due to a more restrictive approach adopted after 2016. We also evaluated the impact on patient outcomes. A total of 146 consecutive HSCT patients were analyzed. In patients without hemorrhagic complications, the Hb threshold for RBC transfusions decreased significantly from 2016 to 2017 (from 7.8 g/dL to 7.3 g/dL; p = 0.010), whereas it remained the same in 2017, 2018, and 2019 (7.3, 7.2, and 7.2 g/dL, respectively). Similarly, the PLT threshold decreased significantly from 2016 to 2017 (from 18,000 to 16,000/μL; p = 0.026) and further decreased in 2019 (15,000/μL). In patients without severe hemorrhagic complications, the number of RBC and PLT transfusions remained very low over time. No increase in 100-day and 180-day non-relapse mortality or adverse events was observed during the study period. No patient died due to hemorrhagic complications. Our preliminary observations support robust studies enrolling HSCT patients in patient blood management programs. more...
- Published
- 2023
- Full Text
- View/download PDF
219. The Italy-Japan Workshop: A History of Bilateral Cooperation, Pushing the Boundaries of Robotics.
- Author
-
Gabriele Trovato, Leonardo Ricotti, Cecilia Laschi, Massimiliano Zecca, Sarah Cosentino, Luca Bartolomeo, Shuji Hashimoto, Atsuo Takanishi, and Paolo Dario
- Published
- 2021
- Full Text
- View/download PDF
220. Factors associated with low health-related quality of life in persons with multiple sclerosis: A quantile-based segmentation approach.
- Author
-
Iaquinto, Stefania, Ineichen, Benjamin Victor, Salmen, Anke, Kuhle, Jens, Benkert, Pascal, Hofer, Lisa, Calabrese, Pasquale, Kamm, Christian P., Roth, Patrick, Zecca, Chiara, Ammann, Sabin, Pot, Caroline, and von Wyl, Viktor more...
- Subjects
SYMPTOM burden ,DISABILITY insurance ,QUANTILE regression ,SYMPTOMS ,QUALITY of life - Abstract
Background: Improving health-related quality of life (HRQoL) is an important disease management goal in persons with Multiple Sclerosis (PwMS). HRQoL decreases with increasing age and prolonged disease duration; other factors remain less understood. Objective: To identify associations of multiple sclerosis (MS) disease characteristics and symptom burden with low HRQoL. Methods: Using the Swiss MS Registry, we applied quantile regression adjusted for age and MS disease duration to determine 25
th (low HRQoL) and 75th (high HRQoL) percentiles of the EuroQol-5-Dimension (EQ-5D) distribution for PwMS. We compared PwMS across HRQoL groups by analyzing differences in sociodemographics, symptom burden, MS risk factors, gait impairment, and the MS Severity Score (MSSS), all measured at the same time as HRQoL. The analyses included descriptive methods, multivariable multinomial regression, and simultaneous quantile regression as a sensitivity analysis. Results: We included 1697 PwMS with median age and time-to-diagnosis of 49 and 9 years. Multivariable regression revealed low HRQoL to be associated with receiving invalidity insurance benefits, reporting depression, muscle weakness, memory problems, pain, and severe gait impairment. The analysis for individuals with available MSSS (n = 937) showed an increasing probability of low HRQoL with higher MSSS. Conclusion: Our segmentation method identified symptom burden and MS severity as factors associated with low HRQoL. Pharmacological and non-pharmacological MS symptom management, especially for depression, fatigue, pain, and muscle weakness, may warrant increased attention to preserve or improve HRQoL. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
- Full Text
- View/download PDF
221. Survival rates and extra‐regional migration patterns of children and adolescents with cancer in Italy: The 30‐year experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) with the Italian hospital‐based registry of pediatric cancer (Mod. 1.01)
- Author
-
Pession, Andrea, Quarello, Paola, Zecca, Marco, Mosso, Maria Luisa, Rondelli, Roberto, Milani, Lorenzo, De Rosa, Marisa, Rosso, Tiziana, Maule, Milena, and Fagioli, Franca
- Subjects
PEDIATRIC oncology ,PEDIATRIC hematology ,CHILDHOOD cancer ,CANCER patients ,SURVIVAL rate - Abstract
Since the 1970s, Italian pediatric oncologists have collaborated through the Italian Association for Pediatric Hematology Oncology (AIEOP) network using a common centralized system for the registration of childhood cancer, known as Model 1.01 (Mod. 1.01). In this study, we report on recruitment trends, extra‐regional migration and changes in outcome over time in the Italian population of children (0–14 years) and adolescents (15–19 years) registered and treated within the national AIEOP network in the period between 1989 and 2017. In almost 30 years, a cohort of 43,564 patients with a neoplasia diagnosis was registered in Mod. 1.01. The analysis of national extra‐regional migration showed that patients tend to migrate from the South to the North and, to a lesser extent, to the Center of the country. During the study period, migration apparently decreased, especially for lymphohematopoietic diseases, whereas it remained substantial for solid tumors. Our data showed a progressive and significant increase in the cumulative survival 5 years after diagnosis since the 1990s, reaching almost 84% for all patients diagnosed in the last decade. Survival rates of Mod. 1.01 patients are similar to those provided by the main national and international reports showing childhood cancer surveillance estimates. The AIEOP Mod 1.01 has proved to be an invaluable tool from both an epidemiological and a health policy point of view, allowing us, in this study, to examine the survival experience of the largest cohort of Italian pediatric cancer patients with a very long follow‐up. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
222. Real-world patterns in remote longitudinal study participation: A study of the Swiss Multiple Sclerosis Registry.
- Author
-
Daniore, Paola, Yan, Chuqiao, Stanikic, Mina, Iaquinto, Stefania, Ammann, Sabin, Kamm, Christian P., Zecca, Chiara, Calabrese, Pasquale, Steinemann, Nina, and von Wyl, Viktor
- Published
- 2024
- Full Text
- View/download PDF
223. Predictability of Maxillary Expansion with Invisalign ® First: Treatment Planning vs. Outcome.
- Author
-
Levrini, Luca, Zecca, Piero Antonio, Deppieri, Alessandro, Caccia, Margherita, Scurati, Eleonora Ivonne, Legramandi, Valentina Angela, and Carganico, Andrea
- Subjects
DENTAL arch ,MIXED dentition ,MAXILLARY expansion ,ORTHODONTIC appliances ,DENTITION ,ARCHES - Abstract
The aim of this study is to retrospectively investigate the predictability of maxillary arch expansion with Invisalign
® First in mixed dentition. In a sample of 64 treated patients, 3D digital models from the ClinCheck® software were compared with post-treatment digital models. Predicted maxillary expansion was related to the final outcome of expansion. At the cuspidal level, there was observed a predictability of 59.68% for deciduous canines, 63.77% for first deciduous molars, 66.99% for second deciduous molars, and 55.61% for first permanent molars. At the gingival level, there was observed a predictability of 49.87% for deciduous canines, 53.11% for first deciduous molars, 53.36% for second deciduous molars, and 45.16% for first permanent molars. The difference between the predicted and achieved expansion was statistically significant (p < 0.05). Within the present limitations, our results suggest that, with Invisalign® First, it is possible to expand the upper arch in mixed dentition in an effective and predictable way. Clear aligners could represent a new and valid alternative for arch expansion in growing patients. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
- Full Text
- View/download PDF
224. Exploring the relationship between neurologists and older persons with multiple sclerosis through the lens of social support theory.
- Author
-
Stanikić, Mina, Gille, Felix, Schlomberg, Jonas, Daniore, Paola, Kägi, Susanne, Chan, Andrew, Kamm, Christian P, Zecca, Chiara, Calabrese, Pasquale, Roth, Patrick, Baum, Claudia, Rapold, Irene, Puhan, Milo A, and von Wyl, Viktor more...
- Subjects
OLDER people ,SOCIAL support ,PATIENTS' attitudes ,MULTIPLE sclerosis ,LIKERT scale - Abstract
Background: Although healthcare practitioners (HCPs) are a valuable source of social support, research on support provided by neurologists to older persons with multiple sclerosis (pwMS) remains limited. Objectives: To explore expectations of pwMS aged 55 years or older regarding MS care and to identify support types, met and unmet needs within their relationship with neurologists. Methods: Utilizing a mixed-methods approach, we analyzed survey data from Swiss Multiple Sclerosis Registry participants. Quantitative data included Likert scales gauging the importance of various aspects of MS care for pwMS both in and out of neurological care. Qualitative data were derived from three open-ended questions, focusing on neurologist-provided support for pwMS in neurological care. Data underwent descriptive and deductive thematic analysis, using Cutrona and Suhr framework for coding social support. Results: Among the 286 participants (median age 61.0 years, interquartile range (IQR) 57.0–66.0; median disease duration 23.5 years, IQR 15.0–31.0), 84.6% (N = 244) were under neurological care. Quantitative findings highlighted the significance of HCP expertise and consultation time. Qualitative analysis identified all social support domains in the neurologist–pwMS relationship, with informational support being most prevalent, followed by emotional support. Neurologists' expertise, availability, comprehensive advising, listening, and validation emerged as key themes. Unmet needs were relatively infrequent and concerned insufficient information on complementary medicine, empathy, and understanding of symptoms like fatigue. Conclusions: Older pwMS see neurologists as adequate providers of comprehensive support and particularly value neurologists' sufficient availability, informational and emotional support. Areas for improvement include attention to complementary medicine and empathy. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
225. Management of fever and associated symptoms in children and adults: an Italian national survey.
- Author
-
Chiaretti, Antonio, Grattagliano, Ignazio, Carlomagno, Francesco, Magi, Massimo, Carbone, Luigi, Zecca, Silvia, Bondone, Claudia, Gatto, Antonio, Di Sarno, Lorenzo, and Franceschi, Francesco
- Subjects
CHILDREN'S hospitals ,HOSPITAL wards ,PHYSICIANS ,INTERNET surveys ,FEVER ,GUARDIAN & ward - Abstract
An advisory committee of Italian experts conducted a national, cross-sectional, web-based survey in June 2024 to describe the current management of fever and associated symptoms in different settings, including primary care, emergency departments, and hospital wards in pediatric and adult patients. The survey covered two domains: participants' features and questions about the main drugs prescribed to treat fever and associated symptoms. A total of 832 questionnaires were analyzed. Paracetamol was the most prescribed drug to treat fever. Most participants were influenced by related symptoms when choosing the most appropriate drug. Almost all participants selected the oral route as their preferred one. This survey provides a current state of fever management among physicians in different settings throughout Italy. It highlights a trend in treating fever with antipyretics at appropriate doses and evaluating pain through validated scales. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
226. North American considerations, strategies, and practices in reducing the sodium content in processed foods.
- Author
-
Trumbo, Paula R., Glass, Kathleen A., Lee, Soo‐Yeun, Moshfegh, Alanna, Welling, Paul A., and Zecca, Patricia
- Subjects
SODIUM content of food ,SALT-free diet ,CONSUMER package goods ,DIETARY sodium ,FOOD science ,PACKAGED foods - Abstract
Most Americans exceed the recommended limit for sodium in their diet, a risk factor for hypertension and cardiovascular disease. Efforts have been made by the food industry and government agencies to reduce the sodium content in foods and encourage the consumption of lower sodium diets. Such efforts, however, are not successful in improving public health when consumers do not accept and consume lower sodium foods. This review article provides an overview of the strategies that have been used by the US food industry to reduce and replace sodium in consumer packaged goods, as well as future sodium reduction strategies and approaches for replacing sodium with potassium salts. Challenges in consumer acceptance regarding the reduction of sodium in foods are also discussed. Because of the widespread consumption of numerous sodium‐containing consumer packaged goods, implementing future strategies in various aspects of salt reduction and potassium replacement in foods should have a profound impact on the health of Americans. Practical Application: New information is provided herein as it discusses the most current and collective perspectives of major food industry successes and challenges, as well as government strategies to decrease sodium intake. The information provided also addresses future strategies for reducing sodium content in foods, increasing potassium intake, and consumer acceptance of lower sodium foods. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
227. Recommendations for the Treatment of Multiple Sclerosis in Family Planning, Pregnancy and Lactation in Switzerland: Immunotherapy.
- Author
-
Graber, Michael, Panchaud, Alice, Legardeur, Helene, Derfuss, Tobias, Friedli, Christoph, Gobbi, Claudio, Zecca, Chiara, Granziera, Cristina, Jelcic, Ilijas, Hammer, Helly Noemi, Bigi, Sandra, Diem, Lara, Kamber, Nicole, Kana, Veronika, Kuhle, Jens, Müller, Stefanie, Salmen, Anke, Hoepner, Robert, Do Canto, Philipp, and Théaudin, Marie more...
- Subjects
MULTIPLE pregnancy ,MULTIPLE sclerosis ,FAMILY planning ,OFF-label use (Drugs) ,PRODUCT attributes ,BREASTFEEDING - Abstract
A large number of disease-modifying immunotherapies are available for the treatment of people with multiple sclerosis. Many disease-modifying immunotherapies show scarce or no safety data in pregnancy and breastfeeding and are labeled as being contraindicated during these periods in the Swiss summary of product characteristics. Some disease-modifying immunotherapies also have restrictions for male patients. Hence, family planning should always be considered in treatment decisions. If clinically necessary, the continuation of immunotherapy during pregnancy can be considered for some substances. In these situations, the "Good Off-Label Use Practice", careful consideration of the benefit–risk profile, and interprofessional cooperation between the treating neurologist, obstetrician–gynecologist, and pharmacist/pharmacologist, ideally with the involvement of experienced centers, is necessary. Here, we present an update on disease-modifying immunotherapies in multiple sclerosis with a focus on family planning, pregnancy, and breastfeeding and provide consensus recommendations of the Medico-Scientific Advisory Board of the Swiss Multiple Sclerosis Society, the Swiss Neurological Society, and the Swiss Society for Gynecology and Obstetrics (represented by the Academy of Fetomaternal Medicine). These unified national recommendations are necessary, as guidelines from other countries differ and because of separate approval/reimbursement situations in Switzerland. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
228. Which innovations for Circular Business Models? A product life-cycle categorisation.
- Author
-
Chioatto, Elisa, Zecca, Emy, and D'Amato, Alessio
- Subjects
CIRCULAR economy ,SMALL business ,BUSINESS models ,ECONOMIC trends ,INNOVATIONS in business - Abstract
Circular Economy has emerged to face current unsustainable economic trends. Clarifying and promoting tools for embedding circularity in firms' business models is becoming crucial. Notwithstanding Eco-Innovation has been recognised as a fundamental link to connect Circular Economy with business models restructuring, still little consensus exists on the interlinkages among the concepts of Eco-Innovation, Circular Economy and Circular Business Models. This research aims to understand which innovations can favour the transition from linear to closed-loop processes, and to identify circular business models using the lens of Eco-Innovation practices. We recognise three groups of innovations that are expected to drive firms' business towards circularity, leading to the identification of an original Product Life-Cycle Categorisation. An exploratory empirical analysis is finally developed on the basis of Italian Small and Medium Enterprises' data, in order to show the ability of our categorisation to distinguish across eco-innovative practices that are driven by (partly) heterogeneous determinants. Highlights: Designing new ways of creating value in accordance with circular economy strategies is becoming crucial The lack of theoretical guidance around the role of Eco-Innovation for circular economy may hinder firms' ability to put in practice circular business models A categorisation of eco-innovative practices desirable for circular economy can support firms to put forward business models changes Heterogeneous drivers are involved in the adoption of different typologies of circular innovations [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
229. PEEK Retainers without CAD-CAM: Simple Solutions for Everyday Challenges.
- Author
-
Zecca, Piero Antonio, Caccia, Margherita, Siani, Lea, Caprioglio, Alberto, and Fastuca, Rosamaria
- Subjects
ORTHODONTIC appliances ,ORTHODONTIC retainers ,NONMETALLIC materials ,CORRECTIVE orthodontics ,THREE-dimensional printing ,ARCHES - Abstract
Background: The need to perform occasional or continuous MRI exams and the interference with metal orthodontic appliances might be important and take a primary role during retention since the retention period is significantly longer than orthodontic treatment. Several non-metallic materials were proposed as potential alternatives to perform fixed retainers in orthodontics, but they showed internal limits. Methods: Polyetheretherketone (PEEK) was used in the present clinical report as a fixed orthodontic retainer in the lower arch in order to perform an appliance with mechanical properties comparable to metallic ones but with a higher biocompatibility material and without the need for removal in case of an MRI exam. The retainer wire was handmade in the studio and then shaped to fit the arch. Results: PEEK showed a good capability for constructing a lingual fixed retainer compared to other aesthetic non-metallic and metallic materials. Conclusions: To the best of our knowledge, this study proposes how to easily build a retainer in PEEK and provides a clinical example of how this material can be beneficial. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
230. Histological Analysis of Oral Tissue Grafting: A Focus on Donor Site Selection.
- Author
-
Zecca, Piero Antonio, Ronchetti, Alice, Cangelosi, Doris, Reguzzoni, Marcella, and Farronato, Davide
- Subjects
HARD palate ,PRINCIPAL components analysis ,RANDOM forest algorithms ,TISSUE analysis ,PREDICTION models ,GINGIVAL grafts - Abstract
The science of dental tissue grafting is evolving, with an increased understanding of factors influencing graft behavior. Despite the widespread clinical use of soft tissue grafts, the histological characteristics of different gingival harvesting sites are still underexplored. This study aimed to fill this gap by analyzing 50 tissue samples harvested from 25 patients across three sites: the hard palate, maxillary tuberosity, and palatal rugae. Each sample underwent thorough histological and histomorphometric analysis. Conventional statistical analysis was performed using SPSS, while predictive modeling was conducted with RapidMiner Studio. The study identified significant histological differences among the graft sites, with notable variations in total graft height, epithelial height, and interdigitation perimeter. These findings underscore the importance of donor site selection in influencing graft success. Pair plots and principal component analysis (PCA) further highlighted the distinct histological features of each tissue type. The random forest classifier identified total graft height, epithelial height, and perimeter as the most influential factors in predicting graft site behavior. This study offers valuable insights into the histological characteristics of soft tissue grafts, potentially leading to more predictable clinical outcomes. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
231. Comparative Morphology of Skeletal Development in Homo sapiens and Raja asterias : Divergent Stiffening Patterns Due to Different Matrix Calcification Processes.
- Author
-
Pazzaglia, Ugo E., Zecca, Piero A., Terova, Genciana, Serena, Fabrizio, Mancusi, Cecilia, Raimondi, Giovanni, Zarattini, Guido, Raspanti, Mario, and Reguzzoni, Marcella
- Subjects
CHONDROGENESIS ,COMPARATIVE anatomy ,CHONDRICHTHYES ,MARINE mammals ,BENDING stresses ,BONE mechanics - Abstract
Simple Summary: Before calcification, the early skeletal development of both Homo sapiens and the chondrichthyan fish Raja asterias is exclusively cartilaginous. This cartilage is formed through tissue segmentation and chondrocyte mitoses. Mineral deposition in the cartilage matrix influences the stiffness and shape of the skeletal segments. In mammals, calcified cartilage serves as a scaffold for bone deposition, which is then remodeled. Conversely, chondrichthyans retain calcified cartilage as their skeletal structure, forming calcification nuclei or "tesserae". These structures adapt to aquatic locomotion. In mammals, endochondral ossification provides limb bones with the necessary stiffness for terrestrial locomotion. X-rays of marine mammals show how endochondral ossification in dolphin flippers adapts to aquatic demands, including shortening of certain bones and an increase in elements in the autopodium's central rays. Before calcification begins, the early embryonic and fetal skeletal development of both mammalian Homo sapiens and the chondrichthyan fish Raja asterias consists exclusively of cartilage. This cartilage is formed and shaped through processes involving tissue segmentation and the frequency, distribution, and orientation of chondrocyte mitoses. In the subsequent developmental phase, mineral deposition in the cartilage matrix conditions the development further. The stiffness and structural layout of the mineralized cartilage have a significant impact on the shape of the anlagen (early formative structure of a tissue, a scaffold on which the new bone is formed) and the mechanical properties of the skeletal segments. The fundamental difference between the two studied species lies in how calcified cartilage serves as a scaffold for osteoblasts to deposit bone matrix, which is then remodeled. In contrast, chondrichthyans retain the calcified cartilage as the definitive skeletal structure. This study documents the distinct mineral deposition pattern in the cartilage of the chondrichthyan R. asterias, in which calcification progresses with the formation of focal calcification nuclei or "tesserae". These are arranged on the flat surface of the endo-skeleton (crustal pattern) or aligned in columns (catenated pattern) in the radials of the appendicular skeleton. This anatomical structure is well adapted to meet the mechanical requirements of locomotion in the water column. Conversely, in terrestrial mammals, endochondral ossification (associated with the remodeling of the calcified matrix) provides limb bones with the necessary stiffness to withstand the strong bending and twisting stresses of terrestrial locomotion. In this study, radiographs of marine mammals (reproduced from previously published studies) document how the endochondral ossification in dolphin flippers adapts to the mechanical demands of aquatic locomotion. This adaptation includes the reduction in the length of the stylopodium and zeugopodium and an increase in the number of elements in the autopodium's central rays. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
232. Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS‐CoV‐2 infection
- Author
-
Maria A. Avanzini, Manuela Mura, Elena Percivalle, Francesca Bastaroli, Stefania Croce, Chiara Valsecchi, Elisa Lenta, Giulia Nykjaer, Irene Cassaniti, Jessica Bagnarino, Fausto Baldanti, Marco Zecca, Patrizia Comoli, and Massimiliano Gnecchi more...
- Subjects
adult stem cells ,angiotensin ,cellular therapy ,fetal stem cells ,mesenchymal stromal cells (MSCs) ,Medicine (General) ,R5-920 ,Cytology ,QH573-671 - Abstract
Abstract Anti‐inflammatory and immune‐modulatory therapies have been proposed for the treatment of COVID‐19 and its most serious complications. Among others, the use of mesenchymal stromal cells (MSCs) is under investigation given their well‐documented anti‐inflammatory and immunomodulatory properties. However, some critical issues regarding the possibility that MSCs could be infected by the virus have been raised. Angiotensin‐converting enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2) are the main host cell factors for the severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2), entry, but so far it is unclear if human MSCs do or do not express these two proteins. To elucidate these important aspects, we evaluated if human MSCs from both fetal and adult tissues constitutively express ACE2 and TMPRSS2 and, most importantly, if they can be infected by SARS‐CoV‐2. We evaluated human MSCs derived from amnios, cord blood, cord tissue, adipose tissue, and bone marrow. ACE2 and TMPRSS2 were expressed by the SARS‐CoV‐2‐permissive human pulmonary Calu‐3 cell line but not by all the MSCs tested. MSCs were then exposed to SARS‐CoV‐2 wild strain without evidence of cytopathic effect. Moreover, we also excluded that the MSCs could be infected without showing lytic effects since their conditioned medium after SARS‐CoV‐2 exposure did not contain viral particles. Our data, demonstrating that MSCs derived from different human tissues are not permissive to SARS‐CoV‐2 infection, support the safety of MSCs as potential therapy for COVID‐19. more...
- Published
- 2021
- Full Text
- View/download PDF
233. Exploring dementia and neuronal ceroid lipofuscinosis genes in 100 FTD-like patients from 6 towns and rural villages on the Adriatic Sea cost of Apulia
- Author
-
Celeste Sassi, Rosa Capozzo, Monia Hammer, Chiara Zecca, Monica Federoff, Cornelis Blauwendraat, Nick Bernstein, Jinhui Ding, J. Raphael Gibbs, Timothy Price, Andrew Singleton, and Giancarlo Logroscino more...
- Subjects
Medicine ,Science - Abstract
Abstract Frontotemporal dementia (FTD) refers to a complex spectrum of clinically and genetically heterogeneous disorders. Although fully penetrant mutations in several genes have been identified and can explain the pathogenic mechanisms underlying a great portion of the Mendelian forms of the disease, still a significant number of families and sporadic cases remains genetically unsolved. We performed whole exome sequencing in 100 patients with a late-onset and heterogeneous FTD-like clinical phenotype from Apulia and screened mendelian dementia and neuronal ceroid lipofuscinosis genes. We identified a nonsense mutation in SORL1 VPS domain (p.R744X), in 2 siblings displaying AD with severe language problems and primary progressive aphasia and a near splice-site mutation in CLCN6 (p.S116P) segregating with an heterogeneous phenotype, ranging from behavioural FTD to FTD with memory onset and to the logopenic variant of primary progressive aphasia in one family. Moreover 2 sporadic cases with behavioural FTD carried heterozygous mutations in the CSF1R Tyrosin kinase flanking regions (p.E573K and p.R549H). By contrast, only a minority of patients carried pathogenic C9orf72 repeat expansions (1%) and likely moderately pathogenic variants in GRN (p.C105Y, p.C389fs and p.C139R) (3%). In concert with recent studies, our findings support a common pathogenic mechanisms between FTD and neuronal ceroid lipofuscinosis and suggests that neuronal ceroid lipofuscinosis genes should be investigated also in dementia patients with predominant frontal symptoms and language impairments. more...
- Published
- 2021
- Full Text
- View/download PDF
234. Case Report: Heterozygous Germline Variant in EIF6 Additional to Biallelic SBDS Pathogenic Variants in a Patient With Ribosomopathy Shwachman–Diamond Syndrome
- Author
-
Ibrahim Taha, Selena Foroni, Roberto Valli, Annalisa Frattini, Pamela Roccia, Giovanni Porta, Marco Zecca, Elena Bergami, Marco Cipolli, Francesco Pasquali, Cesare Danesino, Claudia Scotti, and Antonella Minelli more...
- Subjects
Shwachman–Diamond syndrome ,EIF6 ,SBDS ,whole-exome sequencing ,case report ,Genetics ,QH426-470 - Abstract
Background: Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy mainly characterized by exocrine pancreatic insufficiency, skeletal alterations, neutropenia, and a relevant risk of hematological transformation. At least 90% of SDS patients have pathogenic variants in SBDS, the first gene associated with the disease with very low allelic heterogeneity; three variants, derived from events of genetic conversion between SBDS and its pseudogene, SBDSP1, provided the alleles observed in about 62% of SDS patients.Methods: We performed a reanalysis of the available WES files of a group of SDS patients with biallelic SBDS pathogenic variants, studying the results by next bioinformatic and protein structural analysis. Parallelly, careful clinical attention was given to the patient focused in this study.Results: We found and confirmed in one SDS patient a germline heterozygous missense variant (c.100T>C; p.Phe34Leu) in the EIF6 gene. This variant, inherited from his mother, has a very low frequency, and it is predicted as pathogenic, according to several in silico prediction tools. The protein structural analysis also envisages the variant could reduce the binding to the nascent 60S ribosomal.Conclusion: This study focused on the hypothesis that the EIF6 germline variant mimics the effect of somatic deletions of chromosome 20, always including the locus of this gene, and similarly may rescue the ribosomal stress and ribosomal dysfunction due to SBDS mutations. It is likely that this rescue may contribute to the stable and not severe hematological status of the proband, but a definite answer on the role of this EIF6 variant can be obtained only by adding a functional layer of evidence. In the future, these results are likely to be useful for selected cases in personalized medicine and therapy. more...
- Published
- 2022
- Full Text
- View/download PDF
235. αβT- and B-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation in children with myelodysplastic syndromes
- Author
-
Pietro Merli, Daria Pagliara, Tommaso Mina, Valentina Bertaina, Giuseppina Li Pira, Stefania Lazzaro, Simone Biagini, Federica Galaverna, Luisa Strocchio, Roberto Carta, Maria Luigia Catanoso, Francesco Quagliarella, Marco Becilli, Emilia Boccieri, Francesca Del Bufalo, Arianna Panigari, Annalisa Agostini, Lucia Pedace, Simone Pizzi, Cesare Perotti, Mattia Algeri, Marco Zecca, and Franco Locatelli more...
- Subjects
Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
- Full Text
- View/download PDF
236. Post-acute coronavirus disease 2019 (COVID 19) syndrome: HLH and cholangiopathy in a lung transplant recipient
- Author
-
Silvia Roda, Alessandra Ricciardi, Angela Maria Di Matteo, Marco Zecca, Patrizia Morbini, Marco Vecchia, Teresa Chiara Pieri, Paola Giordani, Angelo Tavano, and Raffaele Bruno
- Subjects
Sars-CoV2 ,Post Covid19 syndrome ,Haemophagocytic lymphohistocytosis ,Post COVID-19 Cholangiopathy ,Infectious and parasitic diseases ,RC109-216 - Abstract
Background: Sars-CoV2 can cause severe pneumonia and acute respiratory distress syndrome (ARDS). In COVID-19-associated respiratory failure, lung transplantation might be an option (Bharat A). Case report: A previously healthy 63-year-old man with a nasopharyngeal swab positive for SarsCoV2 and radiological evidence of interstitial lung consolidations developed acute respiratory distress that required intubation and veno-venous extracorporeal membrane oxygenation support (VV ECMO). Because of no recovery of his lung function, he underwent a bilateral lung transplant. ICU stay was complicated by several episodes of bacterial superinfections and an increase of liver function tests (LFTs). Afterward, he faced a progressive clinical worsening associated to severe anemia, further rise of indices of cholestasis, hypertriglyceridemia and hyperferritinemia. Bone marrow smear showed a picture compatible with haemophagocytic lymphohistocytosis (HLH) and first and second line therapy were started. In addition, a transjugular hepatic biopsy was performed with histopathological evidence of portal and periportal fibrosis, compatible with Covid 19-related cholangiopathy. During the hospital stay, he developed several MDR opportunistic infections. The patient died few months later from multiorgan failure secondary to septic shock. A post-mortem confirmed a diagnosis of cholangiopathy, and medullary erythro-haemophagocytosis. Conclusion: Post Covid19 syndrome is a clinical entity that includes novel and old sequelae following recovery from Sars-CoV2 infections. Early identification of these diseases is crucial for adequate management and might influence the long term prognosis of these patients. more...
- Published
- 2022
- Full Text
- View/download PDF
237. A CLEIA Antigen Assay in Diagnosis and Follow-Up of SARS-CoV-2-Positive Subjects
- Author
-
Salvatore Scarcella, Azzurra Rizzelli, Andrea Fontana, Chiara Zecca, Giancarlo Pasanisi, Katia Musio, Anna Laura Putignano, Valerio Aprile, Alberto Fedele, Pierangelo Errico, Massimiliano Copetti, and Vittorio Tassi more...
- Subjects
SARS-CoV-2 ,nasopharyngeal swabs ,antigenic test ,Microbiology ,QR1-502 - Abstract
ABSTRACT This study includes 259 consecutive nasopharyngeal swabs which tested positive for a molecular SARS-CoV-2 test and 77 subjects who were followed longitudinally, with nasopharyngeal swabs performed weekly until clinical recovery and a negative result for the molecular test were reached. All swabs were also tested with a Lumipulse SARS-CoV-2 chemiluminescence enzyme immunoassay (CLEIA) antigen assay. The antigen test was positive in 169 (65.3%) out of the 259 subjects, while no antigen was detected in 90 subjects (34.7%). In the antigen-positive subjects, clinical status moved slightly toward a more frequent presence of symptoms. Longitudinal follow-up shows how the time of negativization has a faster kinetic in the antigenic test than in the molecular test. Antigenic test result values, considered as a time-dependent covariate and log-transformed, were highly associated with the time to negative swab, with good prediction ability. Receiver operating characteristic (ROC) curve analysis showed a very good discrimination ability of antigenic tests in classifying negative swabs. The optimal cutoff which jointly maximized sensitivity and specificity was 1.55, resulting in an overall accuracy of 0.75, a sensitivity of 0.73, and a specificity of 0.83. After dichotomizing the antigenic test according to the previously determined cutoff value of 1.55, the time-dependent covariate Cox model again suggests a highly significant association of antigenic test values with the time to negative swab molecular: a subject with an antigenic test value lower than 1.55 had almost a 13-fold higher probability to also result negative in the molecular test compared to a subject with an antigenic test value higher than 1.55. IMPORTANCE Our work explores the possibility of using a sensible and reliable antigenic test in a wider range of SARS-CoV-2 diagnostic and clinical applications. Furthermore, this tool seems particularly promising in follow-up with infected subjects, because while the molecular test frequently yields the persistence of low positivities, raising yet unanswered questions, this antigenic test shows more uniform and faster negativization during the evolution of the infection, somehow paralleling the dynamics of infectivity. Although more data will be required to definitely prove it, we believe these findings might be of great interest. more...
- Published
- 2022
- Full Text
- View/download PDF
238. SwissTecLive: effectiveness and safety of dimethyl fumarate in the treatment of RRMS in the Swiss clinical practice setting
- Author
-
Zecca, Chiara, Czaplinski, Adam, Henny, Christophe, Petrini, Liliane, Beeler, Andreas, and Gobbi, Claudio
- Published
- 2020
- Full Text
- View/download PDF
239. Soluble PD-L1 and Circulating CD8+PD-1+ and NK Cells Enclose a Prognostic and Predictive Immune Effector Score in Immunotherapy Treated NSCLC patients
- Author
-
Mazzaschi, G., Minari, R., Zecca, A., Cavazzoni, A., Ferri, V., Mori, C., Squadrilli, A., Bordi, P., Buti, S., Bersanelli, M., Leonetti, A., Cosenza, A, Ferri, L., Rapacchi, E., Missale, G., Petronini, P.G., Quaini, F., and Tiseo, M more...
- Published
- 2020
- Full Text
- View/download PDF
240. Hematopoietic cell transplantation in chronic granulomatous disease: a study of 712 children and adults
- Author
-
Chiesa, Robert, Wang, Junfeng, Blok, Henric-Jan, Hazelaar, Sheree, Neven, Benedicte, Moshous, Despina, Schulz, Ansgar, Hoenig, Manfred, Hauck, Fabian, Al Seraihy, Amal, Gozdzik, Jolanta, Ljungman, Per, Lindemans, Caroline A., Fernandes, Juliana F., Kalwak, Krzysztof, Strahm, Brigitte, Schanz, Urs, Sedlacek, Petr, Sykora, Karl-Walter, Aksoylar, Serap, Locatelli, Franco, Stepensky, Polina, Wynn, Robert, Lum, Su Han, Zecca, Marco, Porta, Fulvio, Taskinen, Mervi, Gibson, Brenda, Matthes, Susanne, Karakukcu, Musa, Hauri-Hohl, Mathias, Veys, Paul, Gennery, Andrew R., Lucchini, Giovanna, Felber, Matthias, Albert, Michael H., Balashov, Dmitry, Lankester, Arjan, Güngör, Tayfun, and Slatter, Mary A. more...
- Published
- 2020
- Full Text
- View/download PDF
241. Psychometric proprieties of the Test of Gross Motor Development–Third Edition in a large sample of Italian children
- Author
-
Magistro, Daniele, Piumatti, Giovanni, Carlevaro, Fabio, Sherar, Lauren B., Esliger, Dale W., Bardaglio, Giulia, Magno, Francesca, Zecca, Massimiliano, and Musella, Giovanni
- Published
- 2020
- Full Text
- View/download PDF
242. Long-term follow-up of 168 patients with X-linked agammaglobulinemia reveals increased morbidity and mortality
- Author
-
Lougaris, Vassilios, Soresina, Annarosa, Baronio, Manuela, Montin, Davide, Martino, Silvana, Signa, Sara, Volpi, Stefano, Zecca, Marco, Marinoni, Maddalena, Baselli, Lucia Augusta, Dellepiane, Rosa Maria, Carrabba, Maria, Fabio, Giovanna, Putti, Maria Caterina, Cinetto, Francesco, Lunardi, Claudio, Gazzurelli, Luisa, Benvenuto, Alessio, Bertolini, Patrizia, Conti, Francesca, Consolini, Rita, Ricci, Silvia, Azzari, Chiara, Leonardi, Lucia, Duse, Marzia, Pulvirenti, Federica, Milito, Cinzia, Quinti, Isabella, Cancrini, Caterina, Finocchi, Andrea, Moschese, Viviana, Cirillo, Emilia, Crescenzi, Ludovica, Spadaro, Giuseppe, Marasco, Carolina, Vacca, Angelo, Cardinale, Fabio, Martire, Baldassare, Trizzino, Antonino, Licciardello, Maria, Cossu, Fausto, Di Matteo, Gigliola, Badolato, Raffaele, Ferrari, Simona, Giliani, Silvia, Pession, Andrea, Ugazio, Alberto, Pignata, Claudio, and Plebani, Alessandro more...
- Published
- 2020
- Full Text
- View/download PDF
243. Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories
- Author
-
Kaufmann, Marco, Salmen, Anke, Barin, Laura, Puhan, Milo Alan, Calabrese, Pasquale, Kamm, Christian Philipp, Gobbi, Claudio, Kuhle, Jens, Manjaly, Zina-Mary, Ajdacic-Gross, Vladeta, Schafroth, Sandra, Bottignole, Britta, Ammann, Sabin, Zecca, Chiara, D'Souza, Marcus, and von Wyl, Viktor more...
- Published
- 2020
- Full Text
- View/download PDF
244. Impact of Obesity on Surgeon Ergonomics in Robotic and Straight-Stick Laparoscopic Surgery
- Author
-
Moss, Esther L., Sarhanis, Panos, Ind, Thomas, Smith, Michael, Davies, Quentin, and Zecca, Massimiliano
- Published
- 2020
- Full Text
- View/download PDF
245. Grading meningiomas utilizing multiparametric MRI with inclusion of susceptibility weighted imaging and quantitative susceptibility mapping
- Author
-
Zhang, Shun, Chiang, Gloria Chia-Yi, Knapp, Jacquelyn Marion, Zecca, Christina M., He, Diana, Ramakrishna, Rohan, Magge, Rajiv S., Pisapia, David J., Fine, Howard Alan, Tsiouris, Apostolos John, Zhao, Yize, Heier, Linda A., Wang, Yi, and Kovanlikaya, Ilhami more...
- Published
- 2020
- Full Text
- View/download PDF
246. Reading underused urban spaces: Aberdeen views
- Author
-
Zecca, Cecilia and Laing, Richard
- Published
- 2020
- Full Text
- View/download PDF
247. Trypanosoma cruzi infections and associated pathology in urban-dwelling Virginia opossums (Didelphis virginiana)
- Author
-
Zecca, Italo B., Hodo, Carolyn L., Slack, Sarah, Auckland, Lisa, and Hamer, Sarah A.
- Published
- 2020
- Full Text
- View/download PDF
248. A Prospective Study of Hematologic Complications and Long-Term Survival of Italian Patients Affected by Shwachman-Diamond Syndrome
- Author
-
Cesaro, Simone, Pegoraro, Anna, Sainati, Laura, Lucidi, Vincenzina, Montemitro, Enza, Corti, Paola, Ramenghi, Ugo, Nasi, Cristina, Menna, Giuseppe, Zecca, Marco, Danesino, Cesare, Nicolis, Elena, Pasquali, Francesco, Perobelli, Sandra, Tridello, Gloria, Farruggia, Piero, and Cipolli, Marco more...
- Published
- 2020
- Full Text
- View/download PDF
249. Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease
- Author
-
Dicarlo, Manuela, primary, Pignataro, Patrizia, additional, Zecca, Chiara, additional, Dell'Abate, Maria Teresa, additional, Urso, Daniele, additional, Gnoni, Valentina, additional, Giugno, Alessia, additional, Borlizzi, Francesco, additional, Zerlotin, Roberta, additional, Oranger, Angela, additional, Colaianni, Graziana, additional, Colucci, Silvia, additional, Logroscino, Giancarlo, additional, and Grano, Maria, additional more...
- Published
- 2024
- Full Text
- View/download PDF
250. Caring for children with cancer evacuated from Ukraine: The patients’ perception
- Author
-
Bolognese, Marcello, primary, Massimino, Maura, additional, Cabibbe, Daniele, additional, Zecca, Marco, additional, Fornara, Marta, additional, Armiraglio, Mariangela, additional, Kyzima, Roman, additional, Luksch, Roberto, additional, Terenziani, Monica, additional, Casanova, Michela, additional, Spreafico, Filippo, additional, Meazza, Cristina, additional, Podda, Marta, additional, Biassoni, Veronica, additional, Schiavello, Elisabetta, additional, Chiaravalli, Stefano, additional, Puma, Nadia, additional, Hovsepyan, Shushan, additional, Bergamaschi, Luca, additional, Gattuso, Giovanna, additional, Nigro, Olga, additional, Grampa, Paolo, additional, Adduci, Annarita, additional, Ferrari, Andrea, additional, and Clerici, Carlo Alfredo, additional more...
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.