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Background: Diabetes is a complicated disease requires continuous clinical care, to govern blood sugar. Aim: To decides the impact of management of L carentin to diabetics at the lipid profile. Methods: This study turned into performed on 120 diabetic Patients had been decided on from endocrinology and diabetes, inside decided on standards. The Patients distributed into three Strata (1st Strata of healthy population and two Strata of patients with diabetes who were on metformin and glibenclamide, one Strata took a L carnitine in a dose of 1000 mg TDS and a Strata dealing with a placebo for a period of ninety days). Results: It is observed those who are on Lcarnitine, confirmed a large discount (p

Background: During treatment, many drugs may become cause of cardiac system toxicity, cytotoxic drugs therapy cause cardiac toxicity, including 5- Fluorouracil (5- FU). It is regarded as antimetabolite which cause its toxic effects during S phase of the cell cycle and got its activation by conversion of thymidine phosphorylase into fluorodeoxyuridylate (5 fluoro 2'deoxyuridine 5'monophosphate, 5-FdUMP) which cause inhibition of thymidylate synthase, which ultimately cause prevention of synthesis of DNA. Aim: To focus on evaluation of ethanolic artichoke extract (Cynara scolymus L) with respect to its cardio protective properties against 5-fluorouracil (5-FU) induced cardio-toxicity in rabbits by estimation of Alanine aminotransferase, creatine kinase and aspartate aminotransferase enzymes in serum. Methods: 4 groups consisting of 8 rabbits each were made for collected 32 rabbits who were albinos. Group I: (negative control) administered dimethyl sulfoxide (DMSO) (2 ml/kg /day) orally on daily basis for duration of 10 days. Group II: (positive control) administered DMSO (2 ml/kg /day) daily via oral route for duration of 10 days and subsequently received dose of 5-FU (150 mg/kg) (single) by intraperitoneal injection, on day 8th day in connection with DMSO. Groups III: administered ethanolic artichoke extract (200 mg/kg/day) orally on daily basis for duration of 10 days. Groups IV: administered ethanolic artichoke extract (200 mg/kg/day) daily on oral basis for 10 days with subsequently single intraperitoneal dose of 5-FU (150 mg/kg) on day 8th day. Results: Before intoxication via 5-FU, treatment of ethanolic artichoke extract note worthily reduces the increase serum levels of AST,CK & ALT enzymes due to cardio toxicity induced via 5-FU- in case of rabbits . Conclusions: With respect to present scenario, extracts of ethanolic artichoke serve as powerful modulator in reducing or masking cardiac toxicity cause by induction of 5-FU in case of rabbits. Keywords: Artichoke Extract, Fluorouracil Induced Cardio toxicity, Ethanolic

The research showed that the French Council of State relied in resolving the conflict between the authority and the citizen on the principles of the Declaration of Human and Citizen Rights as a basis for the principle of legality. He only had them. They are abstract general rules that clarify the basis of the relationship between the citizen and the state, including his rights and duties. The council applied its rules regarding the rulings it issued, whether for the authority or against it. The authority has caved in to that. He also showed that it is impermissible to differentiate between protecting rights in normal and exceptional circumstances. The state is responsible for securing these rights in all circumstances. This is why the board invented the actual employee theory. The basic principles on which the actual employee theory was based have also been studied. The theory is not an exception to the principle of legality, but rather a real application of it. In a state that has taken upon itself to ensure that people enjoy the rights and freedoms stipulated in the constitution. It also clarified that the employee’s organizational relationship with the state requires it to respect his rights stipulated in the law in return for his commitment to his duties that oblige him to apply the law as abstract general rules without bias and deviation. Therefore, it has the right to punish him according to the law. In exchange for his right to appeal the decision to impose the punishment. The judiciary’s decision to cancel the dismissal or dismissal decision obliges the administration to return it to the same legal position. Unless that results in corruption, then you must return him to a center parallel to the first. Without causing him physical or moral harm. The research also showed that what happened in Iraq was a barbaric invasion that was not based on any justification. It expressly contradicts international legality. It has resulted in the abolition of all legitimate institutions of the state and the handing over of power to organizations that have proven practical reality that they are gangs of thieves whose aim is to destroy the state and to violate all prohibited acts. It issued laws that grant themselves privileges and rights that are inconsistent with the principle of legality. And decisions were issued that contradict the public interest. Therefore, citizens and employees should be granted the right to appeal all laws and decisions issued when real authority is established in Iraq. Return all stolen money and stolen rights.

Sektor perniagaan Industri Kecil dan Sederhana (IKS) dianggap penting memandangkan ia memberikan sumbangan yang besar kepada pendapatan ekonomi negara sekali gus melahirkan usahawan muda berjaya. Usahawan muda yang berjaya bukan sahaja mencipta perniagaan baru malahan meningkatkan peluang pekerjaan dan sebagainya. Kejayaan usahawan muda dalam bidang perniagaan IKS memberikan satu impak positif dalam pembangunan ekonomi negara. Oleh itu, objektif kajian adalah bertujuan untuk mengkaji faktor-faktor yang mendorong kejayaan usahawan muda dalam menghadapi cabaran perniagaan Industri Kecil dan Sederhana (IKS) di Malaysia. Kajian ini menggunakan kaedah kuantitatif yang melibatkan seramai 138 orang responden yang kini bergelar Local Champion yang terdiri daripada usahawan muda yang berjaya dalam perniagaan (IKS) masing-masing. Kesemua responden merupakan Local Champion yang telah terlibat secara langsung di dalam Program Rural Business Challenge dan menetap di sekitar Malaysia yang terdiri daripada Zon Timur, Zon Tengah/Selatan, Zon Utara, Sabah dan juga Sarawak. Data yang diperoleh daripada responden akan dianalisis. Faktor pendorong kejayaan yang dikaji dibahagikan kepada 7 dimensi iaitu Sikap/Minat/Kesedaran diri sendiri, Modal, Pemasaran yang baik, Pemikiran Inovatif dan kreatif, Persekitaran Perniagaan, Kemahiran dan Pengetahuan serta Pengurusan Organisasi dan Kerjasama Luar. Dapatan kajian juga menunjukkan bahawa faktor “Sikap, Minat, Kesedaran diri sendiri” bagi seseorang usahawan itu merupakan faktor paling utama yang mendorong kejayaan seseorang usahawan muda dalam menjalankan perniagaan Industri Kecil dan Sederhana (IKS). Kesimpulannya, sikap usahawan yang berdisiplin tinggi dalam mengendalikan perniagaan, berani dan sanggup menghadapi risiko, berfikiran kreatif dan inovatif, sentiasa mendalami ilmu perniagaan sangat menyumbang terhadap kejayaan usahawan muda IKS di Malaysia bagi mengembangkan lagi perniagaan ke arah peringkat global dan akhirnya menyumbang kepada pembangunan ekonomi negara. Segala faktor dimensi cabaran tersebut sangat mempengaruhi seseorang usahawan untuk mencapai kejayaan sekali gus bagi meningkatkan pembangunan ekonomi negara dan usaha ini harus berterusan dilaksanakan untuk menambahbaikkan kualiti kehidupan komuniti dan masyarakat setempat.

Many practical applications for analyzing the reliability of complex system by using fault tree analysis, in this study we introduce fault tree analysis to calculate reliability of safety automatic...

A novel series of quinolone-based heterocyclic derivatives including thiadiazine, thiadiazoles, and triazole were synthesized and their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria were evaluated. Newly synthesized derivatives have been obtained in good yields ranging from 65 to 80%. The synthesized derivatives have been characterized and their structures identified using spectroscopic analysis including NMR, FT-IR, and mass techniques. Most of compounds exhibited moderate-to-good antibacterial activity against all four bacterial strains and are significantly more active than ampicillin. Compounds showed relatively good anti-bacterial activity compared to moderate activity of other compounds. The results obtained herein are important for further structure modifications of quinoline bearing heterocyclic moiety and the exploitation of the therapeutic potential of quinoline derivatives as antibacterial agents.

Social media have become the most readily available and important communication tools in the globalised world of today. As key sources of information, social media are responsible for delivering information and political news to the public making an impact on political support in Malaysia. Hence, the purpose of this study is to examine the role of social media in opening up space for political agenda and support among university students. A quantitative research approach using survey was used for data collection. A Questionnaire was used as an instrument to obtain data on the role of social media in political support among 200 respondents who were students of Universiti Kebangsaan Malaysia (UKM) and Universiti Putra Malaysia (UPM) in Klang Valley, Malaysia’s business hub. Using the Agenda Setting Theory, this study attempts to measure the relationship between political agenda on social media and political support. The findings show that political agenda on social media has a significant relationship with political support. Moreover, political agenda on social media plays a major role in political support. The results further show that social media provides information for understanding political issues in the country and at the same time empowers the people to share information about politics. This implies that social media provide a space for students to engage in political discussion leading to political support. Keywords : Political agenda, political support, social media, university students, youth.

Graphene-fiber (GF) supercapacitors have attracted significant research attention in the field of wearable devices. However, there is still a need for active materials with high energy density. Transition Metal Nitrides (TMNs) are promising candidates for this purpose compared with conventional Transition Metal Oxides (TMOs) or conducting polymers (CPs) owing to their higher electrical conductivity, stability and relevant electrochemical properties. We have successfully integrated Tungsten Nitride (WN) with reduced graphene oxide fibers (rGOF) and developed high-performance hybrid fiber (WN-rGOF) supercapacitors. These hybrid supercapacitors attained a high capacitance of 16.29 F cm-3 at 0.05 A cm-3 and an energy density of 1.448 mW h cm-3, which is 7.5 and 1.75 times higher than those of the pure rGOF supercapacitor and the Tungsten Oxide/rGO hybrid fiber (WO3-rGOF) supercapacitor, respectively. The energy density readily increased up to 2.896 mW h cm-3 when three WN-rGOF supercapacitors were connected in series. The WN-rGOF supercapacitor also showed high capacitance retention of 84.7% after 10 000 cycles along with appreciable performance under severe mechanical deformation.

Tamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to treat breast cancer that spreads to other parts of the human body; it is also utilized to decreasing the chances of breast cancer developing in high-risk patients. Recently, some studies focused on the potential antimicrobial action of TAM. Coronaviruses are enveloped positive-sense RNA nucleic acid viruses that have club-like spikes, characterized by a distinctive replication strategy; they are round and sometimes pleomorphic in shape. Coronavirus disease 2019 (COVID-19) is regarding the new genera of coronaviredia that appeared for the first time in Wuhan, China, in early December 2019. Due to the continuous spread of the novel COVID-19 with the exponential rise in death numbers, new therapeutic development is urgent; in general, there are no specific antiviral drugs or vaccines for 2019-nCoV. Hence, this review will discuss the most recent information about the antiviral action of TAM against COVID-19 infection by trying to give a deep understanding of major properties, mechanisms of action, immune system responses, and antimicrobial efficiency of TAM that is regarding the promising way to treat COVID-19 novel infection. The current review may serve as an impetus for researchers working in the field of medical microbiology, vaccination, and antiviral drug design. The review also rationally reports and critically analyzes the available knowledge by focusing and mentioning future steps and strategies trying to find appropriate solutions regarding challenges in COVID-19 management by TAM utilization.

The aim of this paper is to develop an evidence-based integrated model of destination competitiveness and apply it to the case of Qatar, given that the country has faced a recent blockade and growing competition from destinations in neighboring countries, such as Oman and Saudi Arabia, the UAE and Turkey. From the perspective of visitors’ experiences, a questionnaire based on the Dwyer-Kim integrated model of destination competitiveness is deployed to identify the determinants of tourism performance in Qatar. These determinants were then ranked based on their degree of contribution to tourism performance. The results show that the highest-ranked determinants related to core resources, especially heritage-based artistic and architectural features, such as historic sites and traditional arts and culture. In contrast, natural resources—such as national parks, wildlife, and nature-based activities—were among the lowest-ranked determinants. The findings offer some strategies through which Qatar can improve its level of tourism competitiveness.

Objectives: The present study aimed to compare the stress experience of employees facing to differentiated types of lockdown situations: total vs. partial. It also aimed to identify the cognitive appraisal, coping, stress, and fear of contracting COVID-19 associated with lock down situations among employees. Method: A cross-sectional research design was employed. The sample comprises two groups (n = 490 in each group), complete lockdown (people working from home) and partial lockdown (people going to workplace), and was drawn from Pakistan using purposive sampling technique. Stress Appraisal Measure, Brief COPE Inventory, Perceived Stress Scale, and Fear of Contracting COVID-19 Questionnaire were used to measure cognitive appraisal, coping, stress, and fear, respectively.Results: Independent sample t-test showed that the threat and uncontrollable appraisal was high in people going to workplace as compared to people working from home. Results of binary logistic regression showed that people going to workplace were more likely to cope with COVID-19 situation through seeking instrumental support, behavior disengagement, acceptance, and religion as compared to people working from home. Moreover, people working from home were 0.84 times more likely to cope through emotional support than people going to workplace. Fear was found to be 1.1 times more likely associated with people going to workplace than people working from home.Conclusion: This study would help administrative authorities and government institutions in designing mental health services for working population. It would help the emergency departments in devising first aid management plan to deal with the psychological needs of the workers under pandemic/lockdown situations.

The present study aimed to examine the relationship and prediction of cognitive appraisal and coping with Stress and Fear contracting COVID-19 among the working population of Pakistan. Cross-sectional research design was employed. The data was collected from 980 participants of almost 39 different professions using the purposive sampling technique. Stress Appraisal Measure (Peacock et al., in Stress Med 6:227-236, 1990, http://www.drpaulwong.com/wp-content/uploads/2018/03/Stress-Appraisal-Measure-SAM-Peacock-Wong-1990-Paper.pdf). Brief COPE Inventory (Caver, in Int J Behav Med 4:92-100, 1997), and Perceived Stress Scale (Cohen et al., in J Health Soc Behav 24:385-396, 1983) were used to measure cognitive appraisal, coping, and stress, respectively. Fear was measured by using Fear contracting COVID-19 questionnaire (Ali et al., in J Pakistan Soc Int Med 2(2):140-144, 2021). Age, education, and previously attended stress management training were significantly positively correlated with stress and fear. Females were more stressed and fearful than males. Average time spent on social media was significantly positively correlated with stress. Participants, who were employed, had family members of the older age group above 50 years and had family members with the history of biological diseases were more fearful. Results of hierarchical multiple regression analyses showed that threat, centrality, stressfulness appraisal, and avoidant emotional coping significantly positively predicted stress, whereas control-self appraisal and active emotional coping significantly negatively predicted stress. Moreover, threat, challenge, centrality, stressfulness appraisal, and problem-focused coping significantly positively predicted fear contracting COVID-19, whereas control-self appraisal and active emotional coping significantly negatively predicted fear contracting COVID-19 after controlling for covariates. This study will address the administrative authorities and government institutions to provide first-aid mental health services for emergencies, epidemics, or pandemics in the future.

Heterocyclic nucleus are considered essential in medicinal chemistry and provides a model for developing several therapeutic agents such as drugs with a wide antibacterial spectrum. In an attempt to obtain a new antibacterial agent, new quinolone derivatives containing triazole and thiadiazole have prepared via a straightforward method. The newly synthesized products' chemical structures have invistigated their FT-IR, 1H NMR, 13C NMR, and Mass techniques. A good yield was found for all the prepared derivatives varying from 74-79%. Molecular docking studies of the synthesized compounds showed only one compound, 6c, which has the same ranking from the in vitro and silicon test results on Gram-negative bacteria. Also, several compounds have close rankings, such as compound 5 (ranks 13 and 14) and compound 6c (ranks 6 and 5) in Gram-positive bacteria, as well as compound 7a (ranks 13 and 12), compound 7c (ranks 1 and 2), and compound 7d (ranks 12 and 13) in Gram-negative bacteria. However, there is one exciting compound, 7c, which shows very high rankings (ranks 1 and 2) in Gram-negative bacteria. This suggests that the compound has potential as an antimicrobial in Gram-negative bacteria, with an ampicillin-like mechanism of action targeting the bacteria's Penicillin-binding proteins.

Progression in Computer networks and emerging of new technologies in this field helps to find out new protocols and frameworks that provides new computer network-based services. E-government services, a modernized version of conventional government, are created through the steady evolution of technology in addition to the growing need of societies for numerous services. Government services are deeply related to citizens’ daily lives; therefore, it is important to evolve with technological developments—it is necessary to move from the traditional methods of managing government work to cutting-edge technical approaches that improve the effectiveness of government systems for providing services to citizens. Blockchain technology is among the modern technologies highly suitable for developing digital governance services, and its technological ability to sustain information stability is vital in digital governance systems since it improves integrity and transparency measures while preventing corruption. In this study, computer networking protocols are built to form a peer-to-peer network framework for managing official documents. using blockchain technology was built to illustrate how any element of government work may be developed using it. The suggested framework comprises the addition of a new official document, and the verification of an existing document. The system was created in socket programming using Java and tested the response times for many simultaneous requests. The system was tested using transactions per second (throughput) measurement. The result showed that the proposed system processed 200 document verification transactions within 50 seconds. In addition, the test of the proposed system presented the time required for document retrieval—about three seconds to answer 100 document retrieval transactions. Furthermore, the results of throughput were compared to the results of the same measurement of some popular applications such as bitcoin. And the result of the proposed system was within the average value of output throughput of the other compared applications.

Introduction Transcatheter aortic valve implantation (TAVI) is a well-established procedure in reference centers worldwide and is currently accepted as the method of choice in high- and intermediate-risk patients. Although unusual, catastrophic complications can occur before or after its implantation, such as coronary obstruction, rupture of the aortic valve annulus, cardiac tamponade, significant perivalvular insufficiency and prosthesis embolization/displacement. Data from a recently published North American registry showed that 1,695 patients (2.8%) undergoing TAVI required some type of mechanical circulatory support during [...]

Background Increased breast cancer screening over the past four decades has led to a substantial rise in the diagnosis of ductal carcinoma in situ (DCIS). Although DCIS lesions precede invasive ductal carcinoma (IDC), they do not always transform into cancer. The current standard-of-care for DCIS is an aggressive course of therapy to prevent invasive and metastatic disease resulting in over-diagnosis and over-treatment. Thus, there is a critical need to identify functional determinants of progression of DCIS to IDC to allow discrimination between indolent and aggressive disease. Recent studies show that super-enhancers, in addition to promoting other gene transcription, are themselves transcribed producing super-enhancer associated long noncoding RNAs (SE-lncRNAs). These SE-lncRNAs can interact with their associated enhancer regions in cis and influence activities and expression of neighboring genes. Furthermore, they represent a novel, untapped group of therapeutic targets.MethodsWith an integrative analysis of enhancer loci with global expression of SE-lncRNAs in the MCF10A progression series, we have identified differentially expressed SE-lncRNAs which can identify mechanisms for DCIS to IDC progression. Furthermore, cross-referencing these SE-lncRNAs with patient samples in the TCGA database, we have unveiled 31 clinically relevant SE-lncRNAs that potentially interact with their enhancer to regulate nearby gene expression. To complement SE-lncRNA expression studies, we conducted an unbiased global analysis of super-enhancers that are acquired or lost in progression. ResultsHere we designate SE-lncRNAs RP11-379F4.4 and RP11-465B22.8 as potential markers of progression of DCIS to IDC through regulation of the expression of their neighboring genes (RARRES1 and miR200b respectively). Moreover, we classified 403 super-enhancer regions in MCF10A normal cells, 627 in AT1, 1053 in DCIS, and 320 in CA1 cells. Comparison analysis of acquired/lost super-enhancer regions with super-enhancer regions classified in 47 ER positive patients, 10 Triple Negative Breast Cancer (TNBC) patients, and 11 TNBC cell lines reveal critically acquired pathways including STAT signaling and NF-kB signaling. In contrast, protein folding and local estrogen production are identified as major pathways lost in progression.ConclusionCollectively, these analyses identify differentially expressed SE-lncRNAs and acquired/lost super-enhancers in progression of breast cancer important for promoting DCIS lesions to IDC.

Thermophotovoltaic energy conversion is a solid-state thermal-to-electric energy conversion technique which uses only infrared light i.e., heat. Its maximum achieved efficiency by proper bandgap energy selection and utilizing spectral control strategies is merely 30% which is currently still low to be used as a standalone device for energy harvesting. Recently, researchers used molten metal storage and concentrated solar power (CSP) as an input to derive these thermophotovoltaic blocks. Such blocks usually consist of an emitter and a photovoltaic power converter which boosted the system efficiency by adding a silver-based reflector to bounce unused photons back to the emitter. In this work, we have demonstrated another means of photon recycling on the conversion efficiency by passing the radiations through spectral filters before incident on these cells. The spectral filters were selected by aiming at gaining maximum conversion efficiency and a cylindrical power block was used in order to reduce the conversion losses due to edge effects. The modified model in terms of geometrical shape and spectrally controlled filters was able to achieve a conversion efficiency up to 50% even without using the back surface reflectors (BSRs). This work provides the framework for a cheap and efficient alternative to the combined-cycle electric turbines currently used to convert heat into energy inside utility-scale concentrated solar power facilities. This work enables widespread use wherever solar energy is available in abundance.

According to Frantz Fanon, the third world countries face problem of ethno-religious violence. Pakistan is one of such post-colonial countries. This issue has been depicted by several literary writers such as BapsiSidhwa and Sara Suleri. The research paper analyzes the problem of ethno-religious rivalries in Pakistan. The Indian subcontinent was divided into Pakistan and India in 1947. However, the separation of East Pakistan (Bangladesh) in 1971 due to ethnic politics has raised serious concerns about national identity.The paper aims to answer the most important question as to why Pakistan faces problems of ethno-religious violence after the partition of the United India. In the third-world countries, the ruling elites exploit people on the basis of ethnicity and religion. It results in eruption of ethnic and religious violence in the country. Fanon’s views about neocolonialism are relevant in this context. The study is based on textual analysis (based on interpretation of selected passages) of a novel Ice-Candy Man and a memoir, Meatless Days. The study is significant in highlighting the problems of ethnic politics and religious violence in Pakistan. There is a need of minimizing religious chauvinism and ethnic politics in Pakistan.

Purpose- Qatar has placed its tourism sector as a focal sector in its economic diversification strategy. The country aims to develop diverse tourism products, ranging from cultural, urban, and nature tourism to education. Qatar plans to invest $45 billion in the tourism sector to increase international tourist numbers to seven million per annum by 2030 (Gulf Business, 2014). Given these significant tourism investments, it is unquestionable that the country reaps commensurate long-term benefits in terms of the growth of its tourism sector and possible ripple effects in other sectors of the economy. However, Morakabati et al. (2014) argued that the country's success in attracting tourists was limited due to several reasons. First, it lacks an appealing destination image. Second, civil liberty and political stability in the region are not well acknowledged by potential tourists and third, the country lacks strong promotions of religious and cultural traditions. This current research paper intends to conduct a comparative analysis of Qatar's tourism competitiveness with its strong rivals, namely the United Arab Emirates, Egypt, Saudi Arabia and Turkey. The paper's main objective is to identify Qatar's strengths and weaknesses relative to the competing destinations based on a SWOT analysis.Methodology- The study employs the Global Competitiveness Ranking from Euromonitor and various tourism data sources from the World Bank and Google. It conducts a comparative analysis to identify the strengths, weaknesses, opportunities and threats (SWOT) associated with Qatar's tourism to its competing destinations. Findings- The analysis reveals that the average daily cost of living in Qatar is USD160, which is considerably high compared to Saudi Arabia (USD31), Egypt (USD28) and Turkey (USD98). Even though Qatar's average daily cost is lower than the United Arab Emirates (USD198), the latter destination offers more variety of tourism products than Qatar. Furthermore, the competing nations have invested more resources in tourism development than Qatar. For instance, Qatar's capital investment in travel and tourism services in 2019 was the lowest (USD2.05billion), compared to the United Arab Emirates (USD8.2billion), Saudi Arabia (USD26.87billion), Turkey (USD21.31billion) and Egypt (USD16.2billion). Qatar performed the best in health and financial system among its competitors in terms of global competitiveness ranking.Conclusion- Based upon the analysis, it can be concluded that Qatar has lost its price competitiveness to its neighboring countries. Therefore, the Qatari government should focus on creating opportunities for those who can afford to buy a property and live in Qatar as second-home residents.