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Your search keyword '"BAXENDALE Ian, R."' showing total 709 results
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709 results on '"BAXENDALE Ian, R."'

219. Ethyl 2-hydroxy-2-phenyl-2-(thiazol-2-yl)acetate.

Author

Mallia, Carl J., Englert, Lukas, Walter, Gary C., and Baxendale, Ian R.

Subjects
ACETATES, ETHYL group, ORGANIC synthesis, OXIDATION, FUNCTIONAL groups
Abstract

This short note describes the synthesis of the title compound through spontaneous aerobic oxidation of ethyl 2-phenyl-2-(thiazol-2-yl)acetate. Due to the prevalence of such functional motifs in biologically active substances, we believe the oxidation encountered highlights an important degradation pathway worthy of note. [ABSTRACT FROM AUTHOR]

Published
2015
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220. Syn-Ethyl 1-hydroxy-7-methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinolone-3-carboxylate HCl Salt.

Author

Baumann, Marcus and Baxendale, Ian R.

Subjects
*CHEMICAL synthesis, *CARBOXYLATES, *QUINOLINE derivatives, *HETEROCYCLIC compounds synthesis, *HYDROCHLORIC acid, *HETEROCYCLIC compound derivatives, *PYRROLIDINE, *HYDROGEN bonding
Abstract

This short note describes a one-step synthesis of the title compound from commercially available starting materials and reports its full spectroscopic characterization data. [ABSTRACT FROM AUTHOR]

Published
2015
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221. Back Pressure Regulation of Slurry-Forming Reactions in Continuous Flow.

Author

Deadman, Benjamin J., Browne, Duncan L., Baxendale, Ian R., and Ley, Steven V.

Subjects
CONTINUOUS flow reactors, SLURRY, CHEMICAL processes, SCALABILITY, MASS transfer
Abstract

The handling of solid components in flow chemical processes is still a significant challenge. Current devices for regulating back pressure in laboratory-scale flow chemistry experiments are vulnerable to blockage by solid particulates. A simple device is presented herein for generating back pressure in continuous flow processes that produce chemical slurries. The prototype was constructed from commercially available components and accommodated the use of superheated reaction conditions generated in an agitating cell reactor used to produce a suspended precipitate product. [ABSTRACT FROM AUTHOR]

Published
2015
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222. Sustainable Synthesis of Thioimidazoles via Carbohydrate-BasedMulticomponent Reactions.

Author

Baumann, Marcus and Baxendale, Ian R.

Subjects
*IMIDAZOLES, *CHEMICAL synthesis, *CARBOHYDRATES, *CHEMICAL reactions, *BIFURCATION theory, *ALDOSES, *KETOSES
Abstract

Thesynthesis of diversely functionalized thioimidazoles througha modern variant of the Marckwald reaction is presented. This newprotocol utilizes unprotected carbohydrates as well as simple aminesalts as sustainable and biorenewable starting materials. Importantlyit was discovered that a bifurcated reaction pathway results fromusing aldoses and ketoses respectively, yielding distinct reactionproducts in a highly selective manner. [ABSTRACT FROM AUTHOR]

Published
2014
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248. Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and Its Unnatural Enantiomer by Using Solid-Supported Reagents and Scavengers in a Multistep Sequence of Reactions We gratefully acknowledge financial support from Pfizer Central Research for a Postdoctoral Fellowship (to I.R.B.), the BP endowment and the Novartis Research Fellowship (to S.V.L.), and Pharmacia & Upjohn (to C.P.).

Author

Baxendale, Ian R., primary, Ley, Steven V., additional, and Piutti, Claudia, additional

Published
2002
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