201. Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio as Predictors of Disease Specific Survival After Resection of Adrenocortical Carcinoma
- Author
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Bagante, Fabio, Tran, Thuy B, Postlewait, Lauren M, Maithel, Shishir K, Wang, Tracy S, Evans, Douglas B, Hatzaras, Ioannis, Shenoy, Rivfka, Phay, John E, Keplinger, Kara, Fields, Ryan C, Jin, Linda X, Weber, Sharon M, Salem, Ahmed, Sicklick, Jason K, Gad, Shady, Yopp, Adam C, Mansour, John C, Duh, Quan-Yang, Seiser, Natalie, Solorzano, Carmen C, Kiernan, Colleen M, Votanopoulos, Konstantinos I, Levine, Edward A, Poultsides, George A, and Pawlik, Timothy M
- Subjects
Adult ,Blood Platelets ,Male ,Neutrophils ,Oncology and Carcinogenesis ,Comorbidity ,Article ,Disease-Free Survival ,Clinical Research ,Predictive Value of Tests ,adrenocortical carcinoma ,platelet-lymphocyte ratio ,Adrenocortical Carcinoma ,Humans ,Oncology & Carcinogenesis ,Lymphocyte Count ,Lymphocytes ,neutrophil-lymphocyte ratio ,Neutrophil-Lymphocyte Ratio ,Cancer ,Aged ,Platelet Count ,Inflammatory and immune system ,fungi ,Middle Aged ,Prognosis ,Adrenal Cortex Neoplasms ,body regions ,Surgical Outcomes ,Adrenocortical Carcinoma, Surgical Outcomes, Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio ,Female ,Platelet-Lymphocyte Ratio - Abstract
© 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc. Background The systemic inflammatory response may be associated with tumor progression. We sought to analyze the impact of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on recurrence-free survival (RFS) and disease-specific survival (DSS) among patients who underwent surgery for adrenocortical carcinoma (ACC). Methods Patients undergoing surgery for ACC were identified from a multi-center database. Cut-off values of 5 and 190 were defined as elevated NLR and PLR, respectively, and long-term outcome was assessed. Results Among 84 patients with ACC, 29 (34.%) had NLR>5 while 32 (40.5%) had PLR>190. NLR and PLR were associated with larger tumors (NLR>5: ≤5cm, 0% vs. >5cm, 39.7%; PLR>190: ≤5cm, 0% vs. >5cm, 45.7%), as well as need to resect of other organs (NLR>5: other organ resected 48.8% vs. not resected 20.9%; PLR>190: other organ resected 25.0% vs. not resected 56.4%)(all P5, 10.5%) and PLR (PLR≤190: 19.4% vs. PLR>190: 5.2%) (both P
- Published
- 2015