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784 results on '"Best, Lyle G."'

203. Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study

Author

Dumitrescu, Logan, primary, Carty, Cara L., additional, Taylor, Kira, additional, Schumacher, Fredrick R., additional, Hindorff, Lucia A., additional, Ambite, José L., additional, Anderson, Garnet, additional, Best, Lyle G., additional, Brown-Gentry, Kristin, additional, Bůžková, Petra, additional, Carlson, Christopher S., additional, Cochran, Barbara, additional, Cole, Shelley A., additional, Devereux, Richard B., additional, Duggan, Dave, additional, Eaton, Charles B., additional, Fornage, Myriam, additional, Franceschini, Nora, additional, Haessler, Jeff, additional, Howard, Barbara V., additional, Johnson, Karen C., additional, Laston, Sandra, additional, Kolonel, Laurence N., additional, Lee, Elisa T., additional, MacCluer, Jean W., additional, Manolio, Teri A., additional, Pendergrass, Sarah A., additional, Quibrera, Miguel, additional, Shohet, Ralph V., additional, Wilkens, Lynne R., additional, Haiman, Christopher A., additional, Le Marchand, Loïc, additional, Buyske, Steven, additional, Kooperberg, Charles, additional, North, Kari E., additional, and Crawford, Dana C., additional

Published
2011
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204. Genes associated with endothelial function and risk of pre-eclampsia in an American Indian population

Author

Best, Lyle G., Nadeau, Melanie, Bercier, Shellee, Dauphinais, Sara, Davis, Jacob, Davis, Kylie, Poitra, Shyleen, and Anderson, Cindy M.

Subjects
Native American women -- Health aspects -- Genetic aspects, Endothelium -- Genetic aspects, Preeclampsia -- Risk factors -- Genetic aspects -- Demographic aspects, Science and technology, Genetic aspects, Risk factors, Demographic aspects, Health aspects
Abstract

The etiology of pre-eclampsia (PE) is unknown; but endothelial dysfunction has been hypothesized to play a tole since at least the early 1990's (1). While a number of genes involved [...]

Published
2009

205. Characteristics of two measures of endothelial function among American Indian participants in a case-control study of pre-eclampsia

Author

Best, Lyle G., Bercier, Shellee, Davis, Jacob, Davis, Kylie, Poitra, Shyleen, and Anderson, Cindy M.

Subjects
Native American women -- Health aspects, Endothelium -- Properties, Preeclampsia -- Risk factors -- Physiological aspects -- Demographic aspects, Science and technology, Physiological aspects, Risk factors, Properties, Demographic aspects, Health aspects
Abstract

Background: The etiology of pre-eclampsia (PE) is unknown; but endothelial dysfunction has been hypothesized to play a role since at least the early 1990's. (1) A hallmark of endothelial function [...]

Published
2009

206. GENOME-WIDE LINKAGE MAPPING FOR LEFT VENTRICULAR DIASTOLIC FUNCTION PHENOTYPES IN AMERICAN INDIANS: THE STRONG HEART FAMILY STUDY

Author

Bella, Jonathan N., primary, Cole, Shelley A., additional, Laston, Sandy, additional, Almasy, Laura, additional, Comuzzie, Anthony, additional, Lee, Elisa T., additional, Best, Lyle G., additional, Fabsitz, Richard R., additional, Howard, Barbara V., additional, MacCluer, Jean W., additional, Devereux, Richard B., additional, and Göring, Harald H.H., additional

Published
2011
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210. TWO-DIMENSIONAL ECHOCARDIOGRAPHIC AORTIC ROOT DIMENSIONS IN ADOLESCENTS AND ADULTS: NORMAL LIMITS IN RELATION TO AGE, BODY SIZE AND GENDER

Author

Devereux, Richard B., primary, de Simone, Giovanni, additional, Arnett, Donna K., additional, Best, Lyle G., additional, Boerwinkle, Eric, additional, Howard, Barbara V., additional, Kitzman, Dalane, additional, Lee, Elisa T., additional, Mosley, Thomas H., additional, Weder, Alan, additional, and Roman, Mary J., additional

Published
2010
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212. Recruiting American Indian participants for a genetic epidemiologic study

Author

Nadeau, Melanie A. and Best, Lyle G.

Subjects
Genetic research -- Methods -- Social aspects -- Health aspects, Prevalence studies (Epidemiology) -- Methods -- Social aspects -- Health aspects, Native Americans -- Health aspects -- Social aspects -- Methods, Science and technology, Social aspects, Methods, Health aspects
Abstract

Due to previous negative experiences, some American Indian (AI) communities are distrustful of biomedical research in general and genetic research in particular. The Turtle Mountain Community College was awarded an [...]

Published
2008

213. The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study

Author

Franceschini, Nora, primary, Voruganti, V. Saroja, additional, Haack, Karin, additional, Almasy, Laura, additional, Laston, Sandy, additional, Göring, Harald H. H., additional, Umans, Jason G., additional, Lee, Elisa T., additional, Best, Lyle G., additional, Fabsitz, Richard R., additional, MacCluer, Jean W., additional, Howard, Barbara V., additional, North, Kari E., additional, and Cole, Shelley A., additional

Published
2009
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214. Social- and Behavioral-Specific Genetic Effects on Blood Pressure Traits

Author

Franceschini, Nora, primary, Rose, Kathryn M., additional, Storti, Kristi L., additional, Rutherford, Sue, additional, Voruganti, V. Saroja, additional, Laston, Sandy, additional, Göring, Harald H.H., additional, Dyer, Thomas D., additional, Umans, Jason G., additional, Lee, Elisa T., additional, Best, Lyle G., additional, Fabsitz, Richard R., additional, Cole, Shelley A., additional, MacCluer, Jean W., additional, and North, Kari E., additional

Published
2009
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215. Genetic influence on variation in serum uric acid in American Indians: the strong heart family study

Author

Voruganti, V. Saroja, primary, Göring, Harald H. H., additional, Mottl, Amy, additional, Franceschini, Nora, additional, Haack, Karin, additional, Laston, Sandra, additional, Almasy, Laura, additional, Fabsitz, Richard R., additional, Lee, Elisa T., additional, Best, Lyle G., additional, Devereux, Richard B., additional, Howard, Barbara V., additional, MacCluer, Jean W., additional, Comuzzie, Anthony G., additional, Umans, Jason G., additional, and Cole, Shelley A., additional

Published
2009
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217. Linkage Analysis of Albuminuria

Author

Mottl, Amy K., primary, Vupputuri, Suma, additional, Cole, Shelley A., additional, Almasy, Laura, additional, Göring, Harald H.H., additional, Diego, Vincent P., additional, Laston, Sandra, additional, Shara, Nawar, additional, Lee, Elisa T., additional, Best, Lyle G., additional, Fabsitz, Richard R., additional, MacCluer, Jean W., additional, Umans, Jason G., additional, and North, Kari E., additional

Published
2009
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220. Factor V Leiden genetic variant in an American Indian population

Author

Nadeau, Melanie, Dorsam, Sheri T., Davis, Jacob, Gourneau, Levi, Vallie, Jordan, and Best, Lyle G.

Subjects
Science and technology
Abstract

The clinical condition characterized by an increased propensity to pathologic clot formation is termed 'thrombophilia'. In 1994 Bertina (1) and Greengard (2) independently reported that a genetic variant of the [...]

Published
2007

221. Recruiting American Indian participants for a genetic epidemiologic study

Author

Nadeau, Melanie A. and Best, Lyle G.

Subjects
Science and technology
Abstract

Due to previous negative experiences, some American Indian (AI) communities are distrustful of biomedical research in general and genetic research in particular. The Turtle Mountain Community College was awarded an [...]

Published
2007

222. Linkage analysis of glomerular filtration rate in American Indians

Author

Mottl, Amy K., primary, Vupputuri, Suma, additional, Cole, Shelley A., additional, Almasy, Laura, additional, Göring, Harald H.H., additional, Diego, Vincent P., additional, Laston, Sandra, additional, Franceschini, Nora, additional, Shara, Nawar M., additional, Lee, Elisa T., additional, Best, Lyle G., additional, Fabsitz, Richard R., additional, MacCluer, Jean W., additional, Umans, Jason G., additional, and North, Kari E., additional

Published
2008
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223. Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study

Author

Franceschini, Nora, primary, Almasy, Laura, additional, MacCluer, Jean W, additional, Göring, Harald HH, additional, Cole, Shelley A, additional, Diego, Vincent P, additional, Laston, Sandra, additional, Howard, Barbara V, additional, Lee, Elisa T, additional, Best, Lyle G, additional, Fabsitz, Richard R, additional, and North, Kari E, additional

Published
2008
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225. Linkage study of fibrinogen levels: the Strong Heart Family Study

Author

Best, Lyle G, primary, North, Kari E, additional, Li, Xia, additional, Palmieri, Vittorio, additional, Umans, Jason G, additional, MacCluer, Jean, additional, Laston, Sandy, additional, Haack, Karin, additional, Goring, Harald, additional, Diego, Vincent P, additional, Almasy, Laura, additional, Lee, Elisa T, additional, Tracy, Russell P, additional, and Cole, Shelley, additional

Published
2008
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226. Genome-wide Linkage Analysis of Pulse Pressure in American Indians: The Strong Heart Study

Author

Franceschini, Nora, primary, MacCluer, Jean W., additional, Rose, Kathreen M., additional, Rutherford, Sue, additional, Cole, Shelley A., additional, Laston, Sandy, additional, Göring, Harald H.H., additional, Diego, Vincent P., additional, Roman, Mary J., additional, Lee, Elisa T., additional, Best, Lyle G., additional, Howard, Barbara V., additional, Fabsitz, Richard R., additional, and North, Kari E., additional

Published
2008
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229. A Novel Obesity Locus on Chromosome 4q: The Strong Heart Family Study*

Author

Almasy, Laura, primary, Göring, Harald H.H., additional, Diego, Vincent, additional, Cole, Shelley, additional, Laston, Sandra, additional, Dyke, Bennett, additional, Howard, Barbara V., additional, Lee, Elisa T., additional, Best, Lyle G., additional, Devereux, Richard, additional, Fabsitz, Richard R., additional, and MacCluer, Jean W., additional

Published
2007
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231. Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).

Author

Iyengar, Sudha K., Sedor, John R., Freedman, Barry I., Kao, W. H. Linda, Kretzler, Matthias, Keller, Benjamin J., Abboud, Hanna E., Adler, Sharon G., Best, Lyle G., Bowden, Donald W., Burlock, Allison, Chen, Yii-Der Ida, Cole, Shelley A., Comeau, Mary E., Curtis, Jeffrey M., Divers, Jasmin, Drechsler, Christiane, Duggirala, Ravi, Elston, Robert C., and Guo, Xiuqing

Subjects
DIABETIC nephropathies, ETIOLOGY of kidney diseases, EPIDEMIOLOGY, CHRONIC kidney failure, META-analysis, PATIENTS
Abstract

Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, African American, Mexican American, or American Indian ancestry. A large-scale replication and trans-ethnic meta-analysis included 7,539 additional European American, African American and American Indian DKD cases and non-nephropathy controls. Within ethnic group meta-analysis of discovery GWAS and replication set results identified genome-wide significant evidence for association between DKD and rs12523822 on chromosome 6q25.2 in American Indians (P = 5.74x10-9). The strongest signal of association in the trans-ethnic meta-analysis was with a SNP in strong linkage disequilibrium with rs12523822 (rs955333; P = 1.31x10-8), with directionally consistent results across ethnic groups. These 6q25.2 SNPs are located between the SCAF8 and CNKSR3 genes, a region with DKD relevant changes in gene expression and an eQTL with IPCEF1, a gene co-translated with CNKSR3. Several other SNPs demonstrated suggestive evidence of association with DKD, within and across populations. These data identify a novel DKD susceptibility locus with consistent directions of effect across diverse ancestral groups and provide insight into the genetic architecture of DKD. [ABSTRACT FROM AUTHOR]

Published
2015
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232. Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study.

Author

Kuo, Chin-Chi, Howard, Barbara V., Umans, Jason G., Gribble, Matthew O., Best, Lyle G., Francesconi, Kevin A., Goessler, Walter, Lee, Elisa, Guallar, Eliseo, and Navas-Acien, Ana

Subjects
PHYSIOLOGICAL effects of arsenic, NATIVE element minerals, ARSENIC metabolism, ARSENIC in the body, DIABETES
Abstract

OBJECTIVE Little is known about arsenic metabolism in diabetes development. We investigated the prospective associations of low-moderate arsenic exposure and arsenic metabolism with diabetes incidence in the Strong Heart Study. RESEARCH DESIGN AND METHODS A total of 1,694 diabetes-free participants aged 45-75 years were recruited in 1989-1991 and followed through 1998-1999. We used the proportions of urine inorganic arsenic (iAs), monomethylarsonate (MMA), and dimethylarsinate (DMA) over their sum (expressed as iAs%, MMA%, and DMA%) as the biomarkers of arsenic metabolism. Diabetes was defined as fasting glucose ≥126 mg/dL, 2-h glucose ≥200 mg/dL, self-reported diabetes history, or self-reported use of anti-diabetic medications. RESULTS Over 11,263.2 person-years of follow-up, 396 participants developed diabetes. Using the leave-one-out approach to model the dynamics of arsenic metabolism, we found that lower MMA% was associated with higher diabetes incidence. The hazard ratios (95% CI) of diabetes incidence for a 5% increase in MMA% were 0.77 (0.63-0.93) and 0.82 (0.73-0.92) when iAs% and DMA%, respectively, were left out of the model. DMA% was associated with higher diabetes incidence only when MMA% decreased (left out of the model) but not when iAs% decreased. iAs% was also associated with higher diabetes incidence when MMA% decreased. The association between MMA% and diabetes incidence was similar by age, sex, study site, obesity, and urine iAs concentrations. CONCLUSIONS Arsenic metabolism, particularly lower MMA%, was prospectively associated with increased incidence of diabetes. Research is needed to evaluate whether arsenic metabolism is related to diabetes incidence per se or through its close connections with one-carbon metabolism. [ABSTRACT FROM AUTHOR]

Published
2015
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233. A Quantitative Trait Loci-Specific Gene-by-Sex Interaction on Systolic Blood Pressure Among American Indians

Author

Franceschini, Nora, primary, MacCluer, Jean W., additional, Göring, Harald H.H., additional, Cole, Shelley A., additional, Rose, Kathryn M., additional, Almasy, Laura, additional, Diego, Vincent, additional, Laston, Sandra, additional, Lee, Elisa T., additional, Howard, Barbara V., additional, Best, Lyle G., additional, Fabsitz, Richard R., additional, Roman, Mary J., additional, and North, Kari E., additional

Published
2006
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239. Linkage Analysis of Factors Underlying Insulin Resistance: Strong Heart Family Study

Author

North, Kari E., primary, Almasy, Laura, additional, Göring, Harald H.H., additional, Cole, Shelley A., additional, Diego, Vincent P., additional, Laston, Sandra, additional, Cantu, Teresa, additional, Williams, Jeff T., additional, Howard, Barbara V., additional, Lee, Elisa T., additional, Best, Lyle G., additional, Fabsitz, Richard R., additional, and MacCluer, Jean W., additional

Published
2005
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240. C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes

Author

Best, Lyle G., primary, Zhang, Ying, additional, Lee, Elisa T., additional, Yeh, Jeun-Liang, additional, Cowan, Linda, additional, Palmieri, Vittorio, additional, Roman, Mary, additional, Devereux, Richard B., additional, Fabsitz, Richard R., additional, Tracy, Russell P., additional, Robbins, David, additional, Davidson, Michael, additional, Ahmed, Aftab, additional, and Howard, Barbara V., additional

Published
2005
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244. 1142-183 Association of prehypertension by joint national committee 7 criteria with left ventricular structure and function: The strong heart study

Author

Lawrence Wright, Marilyn B, primary, Devereux, Richard B, additional, Roman, Mary J, additional, Chinali, Marcello, additional, Best, Lyle G, additional, Galloway, James, additional, Fabsitz, Richard R, additional, Lee, Elisa T, additional, Zhang, Ying, additional, and Howard, Barbara V, additional

Published
2004
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249. Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study)**The views expressed here are those of the authors and do not necessarily reflect those of the Indian Health Service.

Author

Chinali, Marcello, primary, Devereux, Richard B, additional, Howard, Barbara V, additional, Roman, Mary J, additional, Bella, Jonathan N, additional, Liu, Jennifer E, additional, Resnick, Helaine E, additional, Lee, Elisa T, additional, Best, Lyle G, additional, and de Simone, Giovanni, additional

Published
2004
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