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201. Vitamin D: Bolus Is Bogus-A Narrative Review

Author

Mazess, Richard B; https://orcid.org/0000-0001-6647-4311, Bischoff‐Ferrari, Heike A; https://orcid.org/0000-0002-4554-658X, Dawson‐Hughes, Bess; https://orcid.org/0000-0003-3136-0386, Mazess, Richard B; https://orcid.org/0000-0001-6647-4311, Bischoff‐Ferrari, Heike A; https://orcid.org/0000-0002-4554-658X, and Dawson‐Hughes, Bess; https://orcid.org/0000-0003-3136-0386

Abstract

In this review we summarize the impact of bolus versus daily dosing of vitamin D on 25(OH)D and 1,25(OH)2D levels, as well as on key countervailing factors that block vitamin D functions at the cellular level. Further, we discuss the role of bolus versus daily dosing of vitamin D for several health outcomes, including respiratory infections and coronavirus disease 2019 (COVID-19), rickets, falls and fractures, any cancer, and cancer-related mortality. This discussion appears timely because bolus doses continue to be tested for various disease outcomes despite a growing amount of evidence suggesting lack of efficacy or even detrimental effects of bolus dosing of vitamin D for outcomes where daily dosing at modest levels was effective in the vitamin D deficient. As a result, these discordant results may bias health recommendations for vitamin D if the recommendations are based on meta-analyses combining both daily and bolus dosing trials. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. Keywords: AGING; CELL/TISSUE SIGNALING; CLINICAL TRIALS; ENDOCRINE PATHWAYS; NUTRITION; PTH/VIT D/FGF23.

Published
2021

205. Secondary attack rates from asymptomatic and symptomatic influenza virus shedders in hospitals: Results from the TransFLUas influenza transmission study

Author

Tamò, Raphaël, primary, Turk, Teja, additional, Böni, Jürg, additional, Kouyos, Roger D., additional, Schmutz, Stefan, additional, Huber, Michael, additional, Shah, Cyril, additional, Bischoff-Ferrari, Heike A., additional, Distler, Oliver, additional, Battegay, Edouard, additional, Giovanoli, Pietro, additional, Guckenberger, Matthias, additional, Kohler, Malcolm, additional, Müller, Rouven, additional, Petry, Heidi, additional, Ruschitzka, Frank, additional, McGeer, Allison, additional, Sax, Hugo, additional, Weber, Rainer, additional, Trkola, Alexandra, additional, and Kuster, Stefan P., additional

Published
2021
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207. Fracture prevention with vitamin D supplementation: A meta-analysis of randomized controlled trails

Author

Bischoff-Ferrari, Heike A., Wong, John B., Willet, Walter C., Giovannucci, Edward, Dietrich, Thomas, and Dawson-Hughes, Bess

Subjects
Alfacalcidol -- Health aspects, Alfacalcidol -- Research, Calcifediol -- Health aspects, Calcifediol -- Research, Vitamin D -- Health aspects, Vitamin D -- Research, Hip joint -- Fractures, Hip joint -- Prevention, Hip joint -- Research
Abstract

An estimation of the effectiveness of vitamin D supplementation in preventing hip and nonvertebral fractures in older persons is presented. It was concluded that oral vitamin D supplementation between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons.

Published
2005

208. Effect of vitamin D on falls

Author

Bischoff-Ferrari, Heike A., Dawson-Hughes, Bess, Willett, Walter C., Staehelin, Hannes B., Bazemore, Marlet G., Zee, Robert Y., and Wong, John B.

Subjects
Calcifediol -- Health aspects, Alfacalcidol -- Health aspects, Vitamin D -- Health aspects, Falls (Accidents) -- Prevention, Aged -- Health aspects
Abstract

Falls among elderly individuals occur frequently which leads to substantial morbidity and mortality. Studies indicate that vitamin D supplementation reduces the risk of falls among ambulatory or institutionalized older individuals and provides stable health by more than 20 percent.

Published
2004

211. Contributors

Author

Abrams, Steven A., primary, Adams, John S., additional, Adams, Judith E., additional, Adorini, Luciano, additional, Anderson, Paul H., additional, Arab, Lenore, additional, Atkins, Gerald J., additional, Berdal, Ariane, additional, Bhan, Ishir, additional, Bikle, Daniel, additional, Bilezikian, John P., additional, Bischoff-Ferrari, Heike, additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Boyan, Barbara D., additional, Brown, Alex J., additional, Brown, Edward M., additional, Bruce, Danny, additional, Burghardt, Andrew J., additional, Burne, Thomas, additional, Calvo, Mona S., additional, Camargo, Carlos A., additional, Cantorna, Margherita, additional, Carlberg, Carsten, additional, Carpenter, Thomas O., additional, Carson, Matthew W., additional, Ceglia, Lisa, additional, Chen, Hong, additional, Chen, Songcang, additional, Christakos, Sylvia, additional, Coe, Fredric L., additional, Compston, Juliet, additional, Cross, Heide S., additional, Cusano, Natalie E., additional, Dawson-Hughes, Bess, additional, De Clercq, Pierre, additional, DeLuca, Hector, additional, Danilenko, Michael, additional, David, Valentin, additional, Deluca, Hector F., additional, Demay, Marie B., additional, de Paula, Francisco J.A., additional, Descroix, Vianney, additional, Dhawan, Puneet, additional, Dixon, Katie M., additional, Dobnig, Harald, additional, Dodge, Jeffrey A., additional, Donnelly, Eve, additional, Doroudi, Maryam, additional, Dowd, Diane R., additional, Drezner, Marc K., additional, Dusso, Adriana S., additional, Ebeling, Peter R., additional, Edouard, Thomas, additional, Eelen, Guy, additional, Eisman, John A., additional, Epps, Tina, additional, Epstein, Ervin H., additional, Epstein, Sol, additional, Eyles, Darryl, additional, Farach-Carson, Mary C., additional, Favus, Murray J., additional, Feldman, David, additional, Findlay, David M., additional, Fleet, James C., additional, Franceschi, Renny T., additional, Fujiki, Ryoji, additional, Gardner, David G., additional, Ginde, Adit A., additional, Giovannucci, Edward, additional, Glenn, Denis J., additional, Glorieux, Francis H., additional, Gocek, Elzbieta, additional, Goltzman, David, additional, González-Sancho, José Manuel, additional, Gordon-Thomson, Clare, additional, Gysemans, Conny, additional, Hansen, Karen E., additional, Haussler, Carol A., additional, Haussler, Mark R., additional, Hayes, Colleen E., additional, Heaney, Robert P., additional, Helvig, Christian, additional, Hendy, Geoffrey N., additional, Hewison, Martin, additional, Hirsch, Arnold Lippert, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Holt, Elizabeth, additional, Hsieh, Jui-Cheng, additional, Insogna, Karl L., additional, Johnson, Candace, additional, Jones, Glenville, additional, Jurutka, Peter W., additional, Kalkwarf, Heidi J., additional, Kato, Shigeaki, additional, Kliewer, Steven A., additional, Koeffler, H. Phillip, additional, Korf, Hannelie, additional, Kouzmenko, Alexander, additional, Kovacs, Christopher S., additional, Kream, Barbara E., additional, Kremer, Richard, additional, Krishnan, Aruna V., additional, Krug, Roland, additional, Kubodera, Noboru, additional, Kumar, Rajiv, additional, Laing, Emma M., additional, Lane, Joseph M., additional, Larriba, María Jesús, additional, Lee, Seong Min, additional, Lewis, Richard D., additional, Li, Yan, additional, Li, Yan Chun, additional, Lian, Jane B., additional, Lichtler, Alexander C., additional, Lips, Paul, additional, Liu, Philip T., additional, Lisse, Thomas S., additional, Ma, Yanfei L., additional, MacDonald, Paul N., additional, Mady, Leila, additional, Maggi, Mario, additional, Majumdar, Sharmila, additional, Makishima, Makoto, additional, Malloy, Peter J., additional, Mangelsdorf, David J., additional, Mansbach, Jonathan M., additional, Manson, JoAnn E., additional, Mason, Rebecca S., additional, Mathieu, Chantal, additional, Mayne, Christopher G., additional, McAlindon, Timothy M., additional, McGrath, John, additional, Meyer, Mark B., additional, Mizwicki, Mathew T., additional, Molla, Muriel, additional, Montecino, Martin, additional, Moras, Dino, additional, Morelli, Annamaria, additional, Morris, Howard A., additional, Muñoz, Alberto, additional, Nanes, Mark S., additional, Nashold, Faye E., additional, Naveh-Many, Tally, additional, Ni, Wei, additional, Nelson, Corwin D., additional, Norman, Anthony W., additional, Ohtake, Fumiaki, additional, Okamoto, Ryoko, additional, Okereke, Olivia I., additional, Pal, Lubna, additional, Petkovich, Martin, additional, Pettifor, John M., additional, Pike, J. Wesley, additional, Pittas, Anastassios G., additional, Plum, Lori A., additional, Prosser, David E., additional, Quarles, L. Darryl, additional, Rebolledo, Brian J., additional, Reichrath, Jörg, additional, Rochel, Natacha, additional, Rosen, Clifford J., additional, Ross, F. Patrick, additional, Sambrook, Philip, additional, Schmidt, Daniel R., additional, Schoch, Ryan D., additional, Schwartz, Gary G., additional, Schwartz, Zvi, additional, Sequeira, Vanessa, additional, Shane, Elizabeth, additional, Shea, M. Kyla, additional, Silver, Justin, additional, Simpson, Robert U., additional, Skingle, Linda, additional, Slatopolsky, Eduardo, additional, Sourij, Harald, additional, Spanier, Justin A., additional, Specker, Bonny L., additional, St-Arnaud, René, additional, Stayrook, Keith R., additional, Stein, Emily M., additional, Stein, Gary S., additional, Stein, Janet L., additional, Studzinski, George P., additional, Takahashi, Fumiaki, additional, Tang, Jean Y., additional, Taylor, Hugh S., additional, Tebben, Peter, additional, Thadhani, Ravi, additional, Thiex, Natalie W., additional, Thompson, William R., additional, Thys-Jacobs, Susan, additional, Tiosano, Dov, additional, Towler, Dwight A., additional, Trump, Donald, additional, Uitterlinden, André G., additional, Unnanuntana, Aasis, additional, Vandewalle, Maurits, additional, van Driel, Marjolein, additional, van Leeuwen, Johannes P.T.M., additional, van Wijnen, Andre J., additional, van Schoor, Natasja, additional, Verlinden, Lieve, additional, Verstuyf, Annemieke, additional, Vieth, Reinhold, additional, Weaver, Connie M., additional, Weinstein, Barrie M., additional, Welsh, JoEllen, additional, White, John H., additional, Whitfield, G. Kerr, additional, Whiting, Susan J., additional, Whyte, Michael P., additional, Wysolmerski, John J., additional, Yamada, Sachiko, additional, and Yip, Ian, additional

Published
2011
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220. The effect of geriatric comanagement (GC) in geriatric trauma patients treated in a level 1 trauma setting: A comparison of data before and after the implementation of a certified geriatric trauma center

Author

Halvachizadeh, Sascha, primary, Gröbli, Lea, additional, Berk, Till, additional, Jensen, Kai Oliver, additional, Hierholzer, Christian, additional, Bischoff-Ferrari, Heike A., additional, Pfeifer, Roman, additional, and Pape, Hans-Christoph, additional

Published
2021
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224. Exercise Reduces the Number of Overall and Major Osteoporotic Fractures in Adults. Does Supervision Make a Difference? Systematic Review and Meta-Analysis

Author

Hoffmann, Isabelle, primary, Shojaa, Mahdieh, additional, Kohl, Matthias, additional, von Stengel, Simon, additional, Becker, Clemens, additional, Gosch, Markus, additional, Jakob, Franz, additional, Kerschan-Schindl, Katharina, additional, Kladny, Bernd, additional, Clausen, Jürgen, additional, Lange, Uwe, additional, Middeldorf, Stefan, additional, Peters, Stefan, additional, Schoene, Daniel, additional, Sieber, Cornel, additional, Tholen, Reina, additional, Thomasius, Friederike, additional, Bischoff-Ferrari, Heike A, additional, Uder, Michael, additional, and Kemmler, Wolfgang, additional

Published
2020
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225. Absenteeism and presenteeism in healthcare workers due to respiratory illness

Author

Kuster, Stefan P., primary, Böni, Jürg, additional, Kouyos, Roger D., additional, Huber, Michael, additional, Schmutz, Stefan, additional, Shah, Cyril, additional, Bischoff-Ferrari, Heike A., additional, Distler, Oliver, additional, Battegay, Edouard, additional, Giovanoli, Pietro, additional, Guckenberger, Matthias, additional, Kohler, Malcolm, additional, Müller, Rouven, additional, Petry, Heidi, additional, Ruschitzka, Frank, additional, McGeer, Allison, additional, Coleman, Brenda L., additional, Sax, Hugo, additional, Weber, Rainer, additional, and Trkola, Alexandra, additional

Published
2020
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226. Is There Any Difference in the Outcome of Geriatric and Non-Geriatric Severely Injured Patients?—A Seven-Year, Retrospective, Observational Cohort Study with Matched-Pair Analysis

Author

Jensen, Kai O., primary, Lempert, Maximilian, additional, Sprengel, Kai, additional, Simmen, Hans P., additional, Pothmann, Carina, additional, Schlögl, Mathias, additional, Bischoff-Ferrari, Heike A., additional, Hierholzer, Christian, additional, Pape, Hans C., additional, and Neuhaus, Valentin, additional

Published
2020
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228. Association of Dance-Based Mind-Motor Activities With Falls and Physical Function Among Healthy Older Adults

Author

Mattle, Michèle, primary, Chocano-Bedoya, Patricia O., additional, Fischbacher, Melanie, additional, Meyer, Ursina, additional, Abderhalden, Lauren A., additional, Lang, Wei, additional, Mansky, Richard, additional, Kressig, Reto W., additional, Steurer, Johann, additional, Orav, E. John, additional, and Bischoff-Ferrari, Heike A., additional

Published
2020
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229. Outcomes after spinal stenosis surgery by type of surgery in adults aged 60 years and older

Author

Degen, Thomas, primary, Fischer, Karina, additional, Theiler, Robert, additional, Schären, Stefan, additional, Meyer, Otto W., additional, Wanner, Guido, additional, Chocano-Bedoya, Patricia, additional, Simmen, Hans-Peter, additional, Schmid, Urs D., additional, Steurer, Johann, additional, Stähelin, Hannes B., additional, Mantegazza, Noemi, additional, and Bischoff-Ferrari, Heike A., additional

Published
2020
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232. Safety and feasibility of a Dalcroze eurhythmics and a simple home exercise program among older adults with mild cognitive impairment (MCI) or mild dementia: the MOVE for your MIND pilot trial

Author

Fischbacher, Melanie, primary, Chocano-Bedoya, Patricia Orializ, additional, Meyer, Ursina, additional, Bopp, Irene, additional, Mattle, Michèle, additional, Kressig, Reto Werner, additional, Egli, Andreas, additional, and Bischoff-Ferrari, Heike Annette, additional

Published
2020
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234. Is there any difference in the outcome of geriatric and non-geriatric severely injured patients? – A seven-year, retrospective, observational cohort study with matched-pair analysis

Author

Jensen, Kai Oliver, primary, Lempert, Maximilian, additional, Sprengel, Kai, additional, Simmen, Hans-Peter, additional, Pothmann, Carina, additional, Schlögl, Mathias, additional, Bischoff-Ferrari, Heike, additional, Hierholzer, Christian, additional, Pape, Hans-Christoph, additional, and Neuhaus, Valentin, additional

Published
2020
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239. Fragility fractures: the future epidemic and its challenges

Author

Bischoff-Ferrari, Heike, University of Zurich, and Bischoff-Ferrari, Heike

Subjects
360 Social problems & social services, 300 Social sciences, sociology & anthropology, 11221 Clinic for Geriatric Medicine, 2741 Radiology, Nuclear Medicine and Imaging
Published
2018

240. List of contributors

Author

Adams, John S., Amrein, Karin, Anderson, Paul H., Arnold, Leggy A., Arora, Juhi, Artusa, Patricio, Ascherio, Alberto, Asmussen, Niels C., Astier, Anne L., Bak, Min Ji, Bauerle, Kevin T., Belorusova, Anna Y., Benkusky, Nancy A., Bernal-Mizrachi, Carlos, Bhattoa, Harjit P., Bikle, Daniel D., Bilezikian, John P., Binkley, Neil C., Bischoff-Ferrari, Heike A., Bishop, Charles W., Blomberg Jensen, Martin, Boisen, Ida Marie, Boucher, Barbara J., Bouillon, Roger, Boyan, Barbara D., Bradford, Dana, Brancatella, Alessandro, Buburuzan, Laura, Burne, Thomas H.J., Buschittari, Damien, Calkins, Hannah, Calvo, Mona S., Camargo, Carlos A., Jr., Campbell, Moray J., Cantorna, Margherita T., Cappellani, Daniele, Carlberg, Carsten, Carmeliet, Geert, Cashman, Kevin D., Ceglia, Lisa, Cetani, Filomena, Chang, Wenhan, Cheadle, Charlotte, Chou, Sharon H., Christakos, Sylvia, Christopher, Kenneth B., Chu, Emily Y., Chun, Rene F., Cleal, Jane K., Cobice, Diego F., Cooper, Cyrus, Coort, Susan L.M., Cui, Xiaoying, Curtis, Elizabeth M., Danilenko, Michael, Darling, Andrea L., David Roodman, G., Dawson-Hughes, Bess, de Jongh, Renate, Demay, Marie B., Dennison, Elaine M., Dixon, Katie M., Dong, Bingning, Doroudi, Maryam, Dusso, Adriana, Dvorzhinskiy, Aleksey, Ebeling, Peter R., Erben, Reinhold G., Evelo, Chris T.A., Eyles, Darryl, Feldman, David, Ferrer-Mayorga, Gemma, Fleet, James C., Forcellati, Marianela, Foster, Brian L., Gafni, Rachel I., Gayan-Ramirez, Ghislaine, Giovannucci, Edward, Girgis, Christian M., Glencross, Drew A., Glorieux, Francis H., Gocek, Elzbieta, Goldfarb, David S., Goltzman, David, González-Sancho, José Manuel, Grant, William B., Groves, Natalie J., Gysemans, Conny, Harrison, Stephanie, Harvey, Nicholas C., Haseltine, Katherine, Hawrylowicz, Catherine M., Hayes, Colleen E., Heckel, John E., Hershberger, Pamela A., Hewison, Martin, Högler, Wolfgang, Holick, Michael F., Hollis, Bruce W., Holt, Rune, Hujoel, Philippe P., Hyppönen, Elina, Ismailova, Aiten, Jablonski, Nina G., Jakobsen, Jette, Janssens, Wim, Jeffery, Louisa, Jenkinson, Carl, Jensen, Marie Bagge, Jetten, Anton M., Jiang, Heng, Johnson, Candace S., Jones, Glenville, Jones, Kerry S., Jüppner, Harald, Kalia, Vandana, Kallay, Enikö, Karapalis, Andrew C., Kaufmann, Martin, Kiely, Mairead, Kim, Hanseul, Kim, Tiffany Y., Kojima, Hiroyuki, Kooij, Ireen, Kovacs, Christopher S., Kremer, Richard, Krieger, Kirsten, Kritmetapak, Kittrawee, Krueger, Diane C., Kumar, Rajiv, Kurihara, Noriyoshi, Lane, Joseph M., Lanham-New, Susan A., Latic, Nejla, LeBoff, Meryl S., Lee, Maija B., Lee, Seong Min, Levine, Michael A., Lewis, Richard, Lewis, Rohan M., Li, Wei, Li, Yan Chun, Lincoln, Matthew R., Lips, Paul, Lisse, Thomas S., Liu, Eva S., López de Maturana, Evangelina, Lugg, Sebastian T., Machado, Christopher J., Maes, Karen, Maestro, Miguel A., Malats, Núria, Malloy, Peter J., Manousaki, Despoina, Marcinkowska, Ewa, Marcocci, Claudio, Martens, Pieter-Jan, Martineau, Adrian R., Mason, Rebecca S., Mathieu, Chantal, Mayne, Phoebe, McGrath, John J., Mehta, Mansi, Mellanby, Richard John, Merchant, Nadia, Meyer, Mark B., Miao, Dengshun, Moon, Rebecca J., Mortensen, Li Juel, Motlaghzadeh, Yasaman, Munger, Kassandra L., Muñoz, Alberto, Nakamichi, Yuko, Narvaez, Carmen J., Nikiphorou, Elena, Nonn, Larisa, Pal, Lubna, Parekh, Dhruv, Pettifor, John M., Pike, J. Wesley, Pilz, Stefan, Pittas, Anastassios G., Pludowski, Pawel, Prosser, David E., Pullagura, Sri Ramulu N., Raphael, Joseph, Rauz, Saaeha, Raza, Karim, Real, Francisco X., Reichrath, Jörg, Richards, J. Brent, Rivadeneira, Fernando, Rochel, Natacha, Roizen, Jeffrey D., Ryan, Brittany A., Sarkar, Surojit, Sarmadi, Fatemeh, Schafer, Anne L., Schepelmann, Martin, Schoenmakers, Inez, Schuit, Frans, Schwartz, Zvi, Scott, Kayla M., Sellmeyer, Deborah E., Sempos, Christopher T., Sepiashvili, Lusia, Seshadri, Mukund, Shane, Elizabeth, Shaurova, Tatiana, Shieh, Albert, Shui, Irene, Singh, Ravinder J., Slominski, Andrzej T., Smith, Karl W., St-Arnaud, René, Stein, Emily M., Studzinski, George P., Suda, Tatsuo, Takahashi, Naoyuki, Taylor, Hugh S., Tebben, Peter J., Thacher, Tom D., Thandrayen, Kebashni, Thickett, David R., Tiosano, Dov, Trajanoska, Katerina, Tu, Chia-Ling, Tuckey, Robert C., Tutaworn, Teerapat, Udagawa, Nobuyuki, Uday, Suma, Unnanuntana, Aasis, van Driel, Marjolein, van Leeuwen, Johannes P.T.M., van Schoor, Natasja, Verlinden, Lieve, Vieth, Reinhold, Vimaleswaran, Karina S., Wagner, Carol L., Wallace, Graham R., Weaver, Connie M., Webb, Daniel A., Welsh, JoEllen, White, John H., Whiting, Susan J., Williams, Emma L., Yahyavi, Sam Kafai, Yamamoto, Keiko, Yates, Clayton, Zagorac, Sladjana, Zhang, Rong Mei, Zhao, Hengguang, Zhou, Ang, and Zittermann, Armin

Published
2023
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244. Sunlight, tanning booths, and vitamin D

Author

Lim, Henry W., Gilchrest, Barbara A., Cooper, Kevin D., Bischoff-Ferrari, Heike A., Rigel, Darrell S., Cyr, W. Howard, Miller, Sharon, DeLeo, Vincent A., Lee, Tim K., Demko, Catherine A., Weinstock, Martin A., Young, Antony, Edwards, Laura Saul, Johnson, Timothy M., and Stone, Stephen P.

Published
2005
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245. Effects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial.

Author

Bischoff-Ferrari, Heike A, Freystätter, Gregor, Vellas, Bruno, Dawson-Hughes, Bess, Kressig, Reto W, Kanis, John A, Willett, Walter C, Manson, JoAnn E, Rizzoli, René, Theiler, Robert, Hofbauer, Lorenz C, Armbrecht, Gabriele, da Silva, José A P, Blauth, Michael, de Godoi Rezende Costa Molino, Caroline, Lang, Wei, Siebert, Uwe, Egli, Andreas, Orav, Endel J, and Wieczorek, Maud

Subjects
CONFIDENCE intervals, CHOLECALCIFEROL, VITAMIN D, DIETARY supplements, RANDOMIZED controlled trials, OMEGA-3 fatty acids, ACCIDENTAL falls, EXERCISE, INDEPENDENT living, STATISTICAL sampling, ODDS ratio, EXERCISE therapy, OLD age
Abstract

Background The roles of vitamin D, omega-3 fatty acids, and home exercise on fall prevention among generally healthy and active older adults are unclear. Objectives We tested the effects of daily supplemental vitamin D, daily supplemental marine omega-3s fatty acids, and a simple home exercise program (SHEP), alone or in combination, on the incidences of total and injurious falls among generally healthy older adults. Methods We performed a 2 × 2 × 2 factorial–design randomized controlled trial among 2157 community-dwelling adults aged 70 years and older, who had no major health events in the 5 years prior to enrolment, recruited from Switzerland, Germany, Austria, France, and Portugal between December 2012 and November 2014. Participants were randomly assigned to supplementation with 2000 international units/day of vitamin D3 and/or 1 g/day of marine omega-3s, and/or a SHEP compared with placebo and/or control exercise over 3 years. The primary endpoint for the present fall analysis was the incidence rate of total falls. Falls were recorded prospectively throughout the trial. Since there were no interactions between treatments, the main effects are reported based on a modified intent-to-treat analysis. Results Of 2157 randomized participants, 1900 (88%) completed the study. The mean age was 74.9 years, 61.7% were women, 40.7% had a serum 25-hydroxyvitamin D concentration < 20 ng/ml, and 83% were at least moderately physically active. In total, 3333 falls were recorded over a median follow-up of 2.99 years. Overall, vitamin D and the SHEP had no benefit on total falls, whilst supplementation with omega-3s compared to no omega-3 supplementation reduced total falls by 10% (incidence rate ratio = 0.90; 95% CI, 0.81–1.00; P  = 0.04). Conclusions Among generally healthy, active, and vitamin D–replete older adults, omega-3 supplementation may have a modest benefit on the incidence of total falls, whilst a daily high dose of vitamin D or a SHEP had no benefit. [ABSTRACT FROM AUTHOR]

Published
2022
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246. Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries.

Author

Schietzel, Simeon, Chocano-Bedoya, Patricia O., Sadlon, Angelique, Gagesch, Michael, Willett, Walter C., Orav, Endel J., Kressig, Reto W., Vellas, Bruno, Rizzoli, René, da Silva, José A. P., Blauth, Michael, Kanis, John A., Egli, Andreas, and Bischoff-Ferrari, Heike A.

Subjects
MONTREAL Cognitive Assessment, OLD age, WALKING speed, LOGISTIC regression analysis, GRIP strength
Abstract

Background: To compare the prevalence of healthy aging among adults age 70 and older from 5 European countries recruited for the DO-HEALTH clinical trial. Participants were selected for absence of prior major health events.Methods: Cross-sectional analysis of DO-HEALTH baseline data. All 2,157 participants (mean age 74.9, SD 4.4; 61.7% women) were included and 2,123 had data for all domains of the healthy aging status (HA) definition. HA was assessed based on the Nurses` Health Study (NHS) definition requiring four domains: no major chronic diseases, no disabilities, no cognitive impairment (Montreal Cognitive Assessment, MoCA ≥25), no mental health limitation (GDS-5 <2, and no diagnosis of depression). Association between HA and age, BMI, gender, and physical function (sit-to-stand, gait speed, grip strength) was assessed by multivariate logistic regression analyses adjusting for center.Results: Overall, 41.8% of DO-HEALTH participants were healthy agers with significant variability by country: Austria (Innsbruck) 58.3%, Switzerland (Zurich, Basel, Geneva) 51.2%, Germany (Berlin) 37.6%, France (Toulouse) 36.7% and Portugal (Coimbra) 8.8% (p <0.0001). Differences in prevalence by country persisted after adjustment for age. In the multivariate model, younger age (OR = 0.95, 95% CI 0.93 to 0.98), female gender (OR = 1.36, 95% CI 1.03 to 1.81), lower BMI (OR = 0.94, 95% CI 0.91 to 0.96), faster gait speed (OR = 4.70, 95% CI 2.68 to 8.25) and faster performance in sit-to-stand test (OR = 0.90, 95% CI 0.87 to 0.93) were independently and significantly associated with HA.Conclusions: Despite the same inclusion and exclusion criteria preselecting relatively healthy adults age 70 years and older, HA prevalence in DO-HEALTH varied significantly between countries and was highest in participants from Austria and Switzerland, lowest in participants from Portugal. Independent of country, younger age, female gender, lower BMI and better physical function were associated with HA.Trial Registration: DO-HEALTH was registered under the protocol NCT01745263 at the International Trials Registry ( clinicaltrials.gov ), and under the protocol number 2012-001249-41 at the Registration at the European Community Clinical Trial System (EudraCT). [ABSTRACT FROM AUTHOR]

Published
2022
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247. Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.

Author

Wieczorek, Maud, Schwarz, Franziska, Sadlon, Angélique, Abderhalden, Lauren A., de Godoi Rezende Costa Molino, Caroline, Spahn, Donat R., Schaer, Dominik J., Orav, E. John, Egli, Andreas, and Bischoff-Ferrari, Heike A.

Abstract

Background: The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults. Aims: To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated with changes from baseline in high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels over 3 years. Methods: This is a post-hoc observational analysis of DO-HEALTH, a double-blind, randomized controlled trial including 2157 European community-dwelling adults age 70+. The outcomes were changes from baseline in hs-CRP and IL-6 levels, measured at 12, 24, and 36 months of follow-up. Iron deficiency was defined by soluble transferrin receptor levels > 28.1 nmol/L and baseline anemia by hemoglobin levels < 130 g/L for men and < 120 g/L for women. Results: In total, 2141 participants were included in the analyses (mean age: 74.9 years, 61.5% of women, 26.8% with iron deficiency). Baseline iron deficiency was associated with greater increase in IL-6 levels (mean difference in change: 0.52 ng/L, 95%CI 0.03–1.00, P =.04) over 3 years. Iron deficiency at any yearly time point was associated with higher increases in hs-CRP (mean difference in change: 1.62 mg/L, 95%CI 0.98–2.26, P <.001) and IL-6 levels (mean difference in change: 1.33 ng/L, 95%CI 0.87–1.79, P <.001) over 3 years. No significant interaction between iron deficiency and anemia was found, suggesting that the results are independent of the anemic status. Conclusions: These findings suggest that iron deficiency may play a role in low-grade chronic inflammation among relatively healthy older adults. [ABSTRACT FROM AUTHOR]

Published
2022
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248. Vitamin D deficiency is common in kidney transplant recipients, but is not associated with infections after transplantation

Author

Schreiber, Peter W, Kusejko, Katharina, Bischoff-Ferrari, Heike A, Boggian, Katia, Bonani, Marco, van Delden, Christian, Enriquez, Natalia, Fehr, Thomas, Garzoni, Christian, Hirsch, Hans H, Hirzel, Cédric, Manuel, Oriol, Meylan, Pascal, Saleh, Lanja, Weisser, Maja, Mueller, Nicolas J, Swiss Transplant Cohort Study, De Geest, Sabina, University of Zurich, and Mueller, Nicolas J

Subjects
medicine.medical_specialty, 11221 Clinic for Geriatric Medicine, 2747 Transplantation, kidney transplantation, 610 Medicine & health, vitamin D, METABOLISM, 030230 surgery, vitamin D deficiency, 10234 Clinic for Infectious Diseases, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Vitamin D and neurology, Humans, 10035 Clinic for Nephrology, infections, ENDOCRINE, Vitamin D, Kidney transplantation, 10038 Institute of Clinical Chemistry, RISK, Transplantation, Kidney, Science & Technology, business.industry, 25-HYDROXYVITAMIN D LEVEL, Odds ratio, Vitamin D Deficiency, medicine.disease, Kidney Transplantation, Transplant Recipients, Confidence interval, medicine.anatomical_structure, Surgery, 030211 gastroenterology & hepatology, infectious disease medicine, business, Life Sciences & Biomedicine, Cohort study
Abstract

The relevance of vitamin D for infections after kidney transplantation is poorly defined. 25-OH vitamin D (25-OHD) levels of 135 kidney transplant recipients, enrolled in the Swiss Transplant Cohort Study, were determined peri-transplant and 6 months post-transplant. Logistic regression was used to address the associations of 25-OHD and overall infections and bacterial infections, respectively. For the first 6 months post-transplant, 25-OHD peri-transplant, and for the second period (after 6 to 30 months post-transplant), 25-OHD at 6 months post-transplant was considered. Vitamin D deficiency was common peri-transplant and remained highly prevalent 6 months after transplantation despite frequent supplementation. Median 25-OHD levels increased from 12.0 ng/mL (IQR 5.3-19.5) peri-transplant to 16.5 ng/mL (IQR 10.6-22.6) 6 months post-transplant (P = .005). We did not detect a significant association between 25-OHD and overall infections (adjusted odds ratio (aOR) 1.05, 95% confidence interval (95%CI) 0.44-2.51; aOR 0.67, 95%CI 0.31-1.43) or bacterial infections (aOR 0.79, 95%CI 0.32-1.96; aOR 0.79, 95%CI 0.35-1.75) for the first and second period. To conclude, at both time points, vitamin D deficiency was observed in more than 50% of kidney recipients, albeit an increase in 25-OHD in the longitudinal course was observed. No significant association between 25-OHD and infections was detected. ispartof: Clinical Transplantation vol:34 issue:2 pages:e13778-e13778 ispartof: location:Denmark status: published

Published
2020
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249. Patient Screening

Author

Buechel, Ronny, Gräni, Christoph, Edwin, Ho, Mizuki, Miura, Pozzoli, Alberto, Gagesch, Michael, Freystätter, Gregor, Bischoff-Ferrari, Heike A, Haager, Philipp K, Rickli, Hans, Feuchtner, Gudrun, Senoner, Thomas, Zuber, Michel, Maisano, Francesco, Alkadhi, H, Kaufmann, Philipp, University of Zurich, Maisano, Francesco, Kaufmann, Philipp, Alkadhi, Hatem, Zuber, Michel, Pozzoli, Alberto, and Ho, Edwin

Subjects
11221 Clinic for Geriatric Medicine, 610 Medicine & health
Published
2020
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