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201. Comparison of knowledge, attitudes and hand hygiene behavioral intention in medical and nursing students.

Author

Cambil-Martin, Jacobo, Fernandez-Prada, Maria Fernandez-Prada, Gonzalez-Cabrera, Joaquin, Rodriguez-Lopez, Cristobalina, Almaraz-Gomez, Ana, Lana-Perez, Alberto, Bueno-Cavanillas, Aurora Bueno-Cavanillas, Cambil-Martin, Jacobo, Fernandez-Prada, Maria Fernandez-Prada, Gonzalez-Cabrera, Joaquin, Rodriguez-Lopez, Cristobalina, Almaraz-Gomez, Ana, Lana-Perez, Alberto, and Bueno-Cavanillas, Aurora Bueno-Cavanillas

Abstract

Introduction: Hand hygiene is crucial to prevent cross infection. Healthcare students are in a prime position to learn hand hygiene skills. The aim of this study was to analyze hand hygiene behavioral intentions of healthcare students before and after contact with the patient and to compare the knowledge of and attitude towards hand hygiene between medical and nursing students. Methods: In a descriptive survey research design, convenience selection of a sample of medical students (n=657) and nursing students (n=303) was done from modules taught by the Department of Preventive Medicine and Public Health in both Medicine and Nursing undergraduate degrees in four Spanish universities. The hand hygiene Questionnaire, a validated instrument to evaluate behavior, knowledge, and attitudes, was used. Results: A significantly lower percentage of students reported always or almost always carrying out hand hygiene before contact with the patient or invasive procedures in comparison to the percentage complying after contact with secretions or with the patient. Although hand hygiene knowledge appears acceptable, its importance is not sufficiently valued.Conclusions: There are deficiencies in behavioral intention, knowledge, and attitudes related to hand hygiene in medical and nursing students. Better results are observed among nursing students, especially those who have received specific training.

Published
2020

205. Clinical practice guidelines and consensus for the screening of breast cancer: A systematic appraisal of their quality and reporting.

Author

Maes‐Carballo, Marta, Mignini, Luciano, Martín‐Díaz, Manuel, Bueno‐Cavanillas, Aurora, and Khan, Khalid Saeed

Subjects
BREAST tumor diagnosis, CONSENSUS (Social sciences), MEDICAL quality control, KRUSKAL-Wallis Test, MEDICAL information storage & retrieval systems, SYSTEMATIC reviews, EARLY detection of cancer, MEDICAL protocols, DESCRIPTIVE statistics, MEDLINE, DATA analysis software
Abstract

Introduction: Clinical practice guidelines (CPGs) and consensus statements (CSs) are being promoted to provide high‐quality healthcare guidance. This systematic review has assessed the breast cancer (BC) screening CPGs and CSs quality and reporting. Methods: A search of bibliographic databases (MEDLINE, Embase, Web of Science, Scopus and CDSR), 12 guideline databases and 51 professional society websites was performed without language restrictions from January 2017 to June 2020, following prospective registration (Prospero no.: CRD42020203807). AGREE II (% of maximum score) and RIGHT (% of total 35 items) appraised quality and reporting individually, extracting data in duplicate; reviewer agreement was 98% and 93%, respectively. Results: Forty guidances with median overall quality and reporting 51% (interquartile range [IQR] 39–63) and 48% (IQR 35–65), respectively. Twenty‐two (55%) and 20 (50%) did not reach the minimum standards (scores <50%). The guidances that deployed systematic reviews had better quality (74.2% vs. 46.9%; p = 0.001) and reporting (80.5% vs. 42.6%; p = 0.001). Guidances reporting a tool referral scored better (AGREE II: 72.8% vs. 43.1%, p = 0.002; RIGHT: 75.0% vs. 46.9%, p = 0.004). Conclusion: BC screening CPGs and CSs suffered poor quality and reporting. More than half did not reach the minimum standards. They would improve if systematic reviews were used to underpin the recommendations made. [ABSTRACT FROM AUTHOR]

Published
2022
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210. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Author

Papandreou, Cristopher and Bueno Cavanillas, Aurora

Subjects
Serum uric acid to creatinine ratio, Serum uric acid, Sleep duration, Actigraphy
Abstract

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations ( β= -0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio ( β= -0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio., The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (three coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926), the Especial Action Project entitled: Implementación y evaluación de una intervención intensives obre la actividad física Cohorte PREDIMED-PLUS grant to Jordi Salas-Salvadó, the European Research Council (Advanced Research Grant 2013–2018; 340918) grant to Miguel Ángel Martínez-Gonzalez, the Recercaixa grant to Jordi Salas-Salvadó (2013ACUP00194), the grant from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant, and FEDER funds (CB06/03). Olga Castaner was granted by the JR17/00022, ISCIII. Christopher Papandreou is supported by a postdoctoral fellowship granted by the Autonomous Government of Catalonia (PERIS 2016–2020 Incorporació de Científics I Tecnòlegs, SLT002/0016/00428). José C. Fernández-García is supported by a research contract from Servicio Andaluz de Salud (SAS) (B-0003-2017). None of the funding sources took part in the design, collection, analysis, or interpretation of the data, or in the decision to submit the manuscript for publication. The corresponding authors had full access to all the data in the study and had final responsibility forsubmitting for publication.

Published
2019

211. Hospitalisation by tick-borne diseases in the last 10 years in two hospitals in South Spain: analysis of tick exposure data collected in the Emergency Department

Author

Rivera Izquierdo, Mario, Martín de los Reyes, Luis Miguel, Láinez Ramos-Bossini, A. J., Ruiz-Díaz, Pilar, Casado-Fernández, Eloisa, and Bueno Cavanillas, Aurora

Abstract

Tick-borne diseases (TBDs) can sometimes cause severe symptoms and lead to hospitalisation, but they often go unnoticed in the Emergency Department (ED). The aim of this study was twofold: (i) to describe the profile of patients hospitalised by TBDs; and (ii) to evaluate the data collected in the medical records from the ED in order to analyse their potential clinical consequences. A total of 84 cases that included all TBD diagnoses registered in the ED records were identified and analysed. These corresponded to all the hospitalisations by TBDs in the last 10 years (2009–2019) in two tertiary hospitals in Granada, Spain. Statistical analyses were made using RStudio. Coinciding with the absence of patient’s report of exposure to ticks, 64.3% of TBDs were not suspected in the ED. Intensive care unit admission was required in 8.3% of cases, and the mortality rate was 2.4%. Non-suspected cases showed longer hospital stay (P < 0.001), treatment duration (P = 0.02) and delay in the initiation of antibiotic treatment (P < 0.001). Our findings indicate that symptoms associated with TBDs are highly non-specific. In the absence of explicit information related to potential tick exposure, TBDs are not initially suspected. As a consequence, elective treatment administration is delayed and hospitalisation time is prolonged. In conclusion, our results highlight the importance of addressing potential exposure to ticks during the ED contact with patients presenting with febrile syndrome.

Published
2019

212. Consumo de carne y productos cárnicos durante el embarazo y riesgo de tener un recién nacido pequeño para su edad gestacional. Un estudio de casos y controles

Author

Cano Ibáñez, Naomi, Martínez Galiano, Juan Miguel, Amezcua Prieto, María Del Carmen, Olmedo Requena, María Rocío, Bueno Cavanillas, Aurora, and Delgado Rodríguez, Miguel

Subjects
Pregnancy, Meat products, food and beverages, Small for gestational age, Maternal nutrition
Abstract

Introduction: different diets during pregnancy might have an impact on the health as reflected by the birth weight of the newborn. The consumption of meat and meat products during pregnancy and its relationship with the newborn health status have been studied by several authors. The studies carried out show inconsistent results Objective: to analyse the association between maternal dietary intake of meat and meat products and the risk of small for gestational age (SGA) newborn. Methods: a matched case-control study of 518 cases and controls of pregnant women was performed in Spain. Cases were women with a SGA newborn. Data about demographic characteristics and diet were collected. Meat consumption was gathered through a validated food frequency questionnaire. Meat and meat products intakes were categorized in quintiles (Q1-Q5).The association between maternal meat and meat product intakes and SGA was assessed by logistic regression models with adjustment for confounding factors. Results: an intake of meat products above 6.8 g/day was associated with a lower risk of SGA delivery (OR = 0.7; 95% CI, 0.53-0.93) after adjusting for smoking, body mass index, previous preterm-low birth weight, newborn gender and adherence to Mediterranean diet. Conclusions: meat consumption was not associated with SGA, whereas meat products showed a moderate protective relationship., Introducción: la ingesta dietética durante el embarazo es un factor clave en la salud maternal y fetal, pudiendo tener un impacto en el peso al nacer del recién nacido. El consumo de carne y productos cárnicos durante el embarazo y su asociación con el estado de salud del neonato ha sido estudiado, sin embargo los hallazgos encontrados muestran resultados contradictorios. Objetivo: analizar la asociación entre la ingesta dietética materna de carne y productos cárnicos durante el embarazo y el riesgo de tener un bebé pequeño para la edad gestacional (PEG). Metodología: se realizó un estudio de casos y controles emparejados en mujeres españolas embarazadas (518 casos y 518 controles). Los casos fueron mujeres con un recién nacido PEG. El consumo de carne se obtuvo a través de un cuestionario de frecuencia de alimentos validado. La carne y la ingesta de productos cárnicos fueron categorizados en quintiles (Q1-Q5). La asociación entre la ingesta materna cárnica durante el embarazo y el riesgo de tener un recién nacido PEG se evaluó mediante modelos de regresión logística ajustados por factores confusores. Resultados: una ingesta de productos cárnicos ≥ 6,8 g/día se asoció significativamente con un menor riesgo de tener un recién nacido PEG (OR = 0,7; IC 95%, 0,53-0,93) después de ajustar el modelo por factores confusores: fumar, índice de masa corporal, embarazos previos con bajo peso al nacer, sexo del recién nacido y adherencia materna a la dieta mediterránea. Conclusiones: el consumo materno de carne no se asoció con recién nacidos PEG, sin embargo el consumo de productos cárnicos mostró una moderada asociación protectora. Estos hallazgos respaldan el consejo de una dieta variada para mujeres embarazadas, que proporciona ingesta de proteínas y otros micronutrientes de diferentes fuentes alimentarias.

Published
2019

213. Harmonising research outcomes for polycystic ovary syndrome: an international multi-stakeholder core outcome set

Author

Al Wattar, Bassel H, primary, Teede, Helena, primary, Garad, Rhonda, primary, Franks, Steve, primary, Balen, Adam, primary, Bhide, Priya, primary, Piltonen, Terhi, primary, Romualdi, Daniela, primary, Laven, Joop, primary, Thondan, Mala, primary, Bueno-Cavanillas, Aurora, primary, Moss, Ngawai, primary, Andrews, Caroline, primary, Hawkes, Rachel, primary, Mol, Ben W, primary, Khan, Khalid S, primary, and Thangaratinam, Shakila, primary

Published
2020
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215. Mediterranean diet and quality of life: Baseline cross-sectional analysis of the PREDIMED-PLUS trial

Author

Galilea-Zabalza, Iñigo, Buil-Cosiales, Pilar, Salas-Salvadó, Jordi, Toledo, Estefanía, Ortega-Azorín, C., Díez-Espino, J., Bueno Cavanillas, Aurora, and Predimed-Plus Investigators

Abstract

We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55±70 years) participating in the PREDIMED- Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energyrestricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone. Participants answered a 36-item questionnaire about health-related quality of life (HRQoL) and a 17-item questionnaire that assessed adherence to an MedDiet. We used ANCOVA and multivariableadjusted linear regression models to compare baseline adjusted means of the quality of life scales according to categories of adherence to the MedDiet. Higher adherence to the Med- Diet was independently associated with significantly better scores in the eight dimensions of HRQoL. Adjusted differences of > = 3 points between the highest and the lowest dietary adherence groups to the MedDiet were observed for vitality, emotional role, and mental health and of > = 2 points for the other dimensions. In conclusion, this study shows a positive association between adherence to a MedDiet and several dimensions of quality of life., This project is funded by the European Research Council (Advanced Research Grant 2013-2018; 340918) granted to MAM-G, the Spanish Ministry of Health - Instituto de Salud Carlos III (ISCIII) for the periods 2014-2016, 2015- 2017, 2017-2019 and 2018-2020, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS grants lead by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/ 00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728 PI13/01090 PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01374, PI14/01919, PI14/00853, PI16/00743 PI16/00501, PI17/ 000508), by a Recercaixa grant 2013 (2013ACUP00194), by a grant from the Consejería de Salud de la Junta de Andalucía (PI0458/2013), and a SEMERGEN grant.

Published
2018

217. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic Syndrome

Author

Sayón-Orea, Carmen, primary, Razquin, Cristina, additional, Bulló, Mónica, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, López-Miranda, José, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Sánchez, Vicente Martín, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Sorlí, José V., additional, Castañer, Olga, additional, Fiol, Miquel, additional, Navarrete-Muñoz, Eva M., additional, Arós, Fernando, additional, Gómez-Gracia, Enrique, additional, Zulet, M. Angeles, additional, Sánchez-Villegas, Almudena, additional, Casas, Rosa, additional, Bernal-López, Rosa, additional, Santos-Lozano, José M., additional, Corbella, Emili, additional, Bouzas, Cristina, additional, García-Arellano, Ana, additional, Basora, Josep, additional, Asensio, Eva M., additional, Schröder, Helmut, additional, Moñino, Manuel, additional, García de la Hera, Manoli, additional, Tojal-Sierra, Lucas, additional, Toledo, Estefanía, additional, Díaz-López, Andrés, additional, Goday, Albert, additional, Salas-Salvadó, Jordi, additional, and Martínez-González, Miguel A., additional

Published
2019
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218. Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome

Author

Papandreou, Christopher, primary, Díaz-López, Andrés, additional, Babio, Nancy, additional, Martínez-González, Miguel A., additional, Bulló, Mónica, additional, Corella, Dolores, additional, Fitó, Montse, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, Alfredo J., additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Fernández-García, José C., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, Garcia-Rios, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Becerra-Tomas, Nerea, additional, Martinez-Lacruz, Raul, additional, Schröder, Helmut, additional, Konieczna, Jadwiga, additional, Garcia-de-la-Hera, Manoli, additional, Moreno-Rodriguez, Anai, additional, Barón-López, Javier, additional, Pérez-Farinós, Napoleón, additional, Abete, Itziar, additional, Bautista-Castaño, Inmaculada, additional, Casas, Rosa, additional, Muñoz-Garach, Araceli, additional, Santos-Lozano, José M., additional, Trias, Ferran, additional, Gallardo-Alfaro, Laura, additional, Ruiz-Canela, Miguel, additional, Barragan, Rocio, additional, Goday, Alberto, additional, Galmés-Panadés, Aina M., additional, González-Botella, Andrés, additional, Vaquero-Luna, Jessica, additional, Toledo, Estefanía, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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219. High sleep variability predicts a blunted weight loss response and short sleep duration a reduced decrease in waist circumference in the PREDIMED-Plus Trial

Author

Papandreou, Christopher, primary, Bulló, Mónica, additional, Díaz-López, Andrés, additional, Martínez-González, Miguel A., additional, Corella, Dolores, additional, Castañer, Olga, additional, Vioque, Jesus, additional, Romaguera, Dora, additional, Martínez, Alfredo J., additional, Pérez-Farinós, Napoleón, additional, López-Miranda, Jose, additional, Estruch, Ramon, additional, Bueno-Cavanillas, Aurora, additional, Alonso-Gómez, Angel, additional, Tur, Josep A., additional, Tinahones, Francisco J., additional, Serra-Majem, Luis, additional, Martin, Vicente, additional, Lapetra, Jose, additional, Vazquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Damiel, Lidia, additional, Delgado-Rodriguez, Miguel, additional, Ros, Emilio, additional, Abete, Itziar, additional, Barón-López, Javier, additional, Garcia-Arellano, Ana, additional, Sorli, Jose V., additional, Babio, Nancy, additional, Schröder, Helmut, additional, Toledo, Estefania, additional, Fitó, Montse, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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220. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study

Author

Paz-Graniel, Indira, primary, Babio, Nancy, additional, Serra-Majem, Luís, additional, Vioque, Jesús, additional, Zomeño, Maria Dolores, additional, Corella, Dolores, additional, Díaz-López, Andrés, additional, Pintó, Xavier, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Daimiel, Lidia, additional, Martínez, J. Alfredo, additional, Becerra-Tomás, Nerea, additional, Navarrete-Muñoz, Eva Mª, additional, Schröder, Helmut, additional, Fernández-Carrión, Rebeca, additional, Ortiz-Andrellucchi, Adriana, additional, Corbella, Emili, additional, Riquelme-Gallego, Blanca, additional, Gallardo-Alfaro, Laura, additional, Micó, Víctor, additional, Zulet, Marian, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Ruiz-Canela, Miguel, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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221. Adherence to a priori dietary indexes and baseline prevalence of cardiovascular risk factors in the PREDIMED-Plus randomised trial

Author

Alvarez-Alvarez, Ismael, primary, Toledo, Estefanía, additional, Lecea, Oscar, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Buil-Cosiales, Pilar, additional, Zomeño, María Dolores, additional, Vioque, Jesús, additional, Martinez, J. Alfredo, additional, Konieczna, Jadwiga, additional, Barón-López, Francisco J., additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bueno-Cavanillas, Aurora, additional, Alonso-Gómez, Ángel M., additional, Tur, Josep A., additional, Tinahones, Francisco J., additional, Serra-Majem, Lluís, additional, Martín, Vicente, additional, Ortega-Calvo, Manuel, additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, González, José I., additional, Díaz-López, Andrés, additional, Paz-Graniel, Indira, additional, Muñoz, Miguel A., additional, Fito, Montse, additional, Pertusa-Martinez, Salvador, additional, Abete, Itziar, additional, García-Ríos, Antonio, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, and Martínez-González, Miguel Á., additional

Published
2019
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222. Dietary Diversity and Nutritional Adequacy among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Author

Cano-Ibáñez, Naomi, primary, Gea, Alfredo, additional, Martínez-González, Miguel A., additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, M. Dolors, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Aros, Fernando, additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Lluis, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, García-Ríos, Antonio, additional, Riquelme-Gallego, Blanca, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Daimiel, Lidia, additional, Martín, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Díaz-López, Andrés, additional, Fernández-Carrión, Rebeca, additional, Fitó, Montserrat, additional, Konieczna, Jadwiga, additional, Notario-Barandiaran, Leyre, additional, Alonso-Gómez, Ángel M., additional, Contreras-Fernández, Eugenio, additional, Abete, Itziar, additional, Sánchez-Villegas, Almudena, additional, Casas, Rosa, additional, Muñoz-Garach, Araceli, additional, Santos-Lozano, José Manuel, additional, Gallardo-Alfaro, Laura, additional, Basora, Josep, additional, Portoles, Olga, additional, Muñoz, Miguel Ángel, additional, Moñino, Manuel, additional, Miralles Gisbert, Salvador Miralles, additional, Rodríguez, Anai Moreno, additional, Ruiz-Canela, Miguel, additional, Palau Galindo, Antoni Palau, additional, Pérez-Vega, Karla Alejandra, additional, and Bueno-Cavanillas, Aurora, additional

Published
2019
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224. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Author

Papandreou, Christopher, primary, Babio, Nancy, additional, Díaz-López, Andrés, additional, Martínez-González, Miguel, additional, Becerra-Tomas, Nerea, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Muñoz-Garach, Araceli, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Bulló, Mónica, additional, Sorli, Jose, additional, Quifer, Mireia, additional, Colom, Antoni, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Barón-López, Javier, additional, Pérez-Farinós, Napoleón, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Fernández-Garcia, José, additional, Santos-Lozano, José, additional, Corbella, Emili, additional, del M. Bibiloni, Maria, additional, Diez-Espino, Javier, additional, Asensio, Eva, additional, Torras, Laura, additional, Morey, Marga, additional, Compañ-Gabucio, Laura, additional, Salaverria-Lete, Itziar, additional, Cenoz-Osinaga, Juan, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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226. Adherence to recommended intake of pulses and related factors in university students in the UniHcos project.

Author

Morales-Suárez-Varela, María, Amezcua-Prieto, Carmen, Peraita-Costa, Isabel, Ayan Pérez, Carlos, Valero Juan, Luis Félix, Ortiz-Moncada, Rocío, Almaraz Gómez, Ana, Alguacil Ojeda, Juan, Delgado Rodriguez, Miguel, Blázquez Abellán, Gemma, Jesús Cabero, María, Jiménez Mejías, Eladio, Llopis-Morales, Agustín, Bueno Cavanillas, Aurora, and Fernández-Villa, Tania

Subjects
RESEARCH, PSYCHOLOGY of college students, LEGUMES, CONFIDENCE intervals, CROSS-sectional method, INGESTION, NUTRITIONAL requirements, MEDICAL cooperation, SOCIOECONOMIC factors, HEALTH behavior, DESCRIPTIVE statistics, QUESTIONNAIRES, RESIDENTIAL patterns, ODDS ratio, STUDENT attitudes, LONGITUDINAL method
Abstract

Pulses such as peas, beans or lentils are one of the most complete foods at the nutritional level; however, they are one of the most often neglected foods in the diets of university students. Entrance to university translates into a major lifestyle change for many young people, and the habits acquired or cemented at this time will remain into adulthood. The objective of this study is to analyse the association between personal/sociodemographic factors, dietary intake of other food groups and the consumption of pulses in first-year university students. This cross-sectional study is part of the UniHcos project, a multicentre study of multipurpose prospective cohorts in eleven Spanish universities. Data from 9862 university students were collected through an online self-questionnaire completed by all students who met the selection criteria and agreed to participate in the project during the 2011–2018 academic years. Of students, 75·8 % presented an inadequate (≤2 times/week) consumption of pulses. Living outside the family home in either a student residence (OR 0·76; 95 % CI 0·69, 0·84) or rental (OR 0·81; 95 % CI 0·70, 0·95) decreased the compliance with recommendations on the consumption of pulses. Low consumption of pulses is seemingly not restricted to a specific profile or dietary pattern among university students, and no specific focus group for intervention can be identified. Policies promoting the consumption of pulses among the university population as a whole are necessary to increase compliance rates with the dietary recommendations. [ABSTRACT FROM AUTHOR]

Published
2021
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227. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Author

Papandreou, Christopher, Babio, Nancy, Díaz-López, Andrés, Martínez-González, Miguel, Becerra-Tomas, Nerea, Corella, Dolores, Schröder, Helmut, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel, Wärnberg, Julia, Martínez, Alfredo, Serra-Majem, Lluís, Estruch, Ramon, Muñoz-Garach, Araceli, Lapetra, José, Pintó, Xavier, Tur, Josep, Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Bulló, Mónica, Sorli, Jose, Quifer, Mireia, Colom, Antoni, Oncina-Canovas, Alejandro, Tojal-Sierra, Lucas, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Sanchez-Villegas, Almudena, Casas, Rosa, Fernández-Garcia, José, Santos-Lozano, José, Corbella, Emili, del M. Bibiloni, Maria, Diez-Espino, Javier, Asensio, Eva, Torras, Laura, Matía Martín, María Del Pilar, Morey, Marga, Compañ-Gabucio, Laura, Salaverria-Lete, Itziar, Cenoz-Osinaga, Juan, Castañer, Olga, Salas-Salvadó, Jordi, Papandreou, Christopher, Babio, Nancy, Díaz-López, Andrés, Martínez-González, Miguel, Becerra-Tomas, Nerea, Corella, Dolores, Schröder, Helmut, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel, Wärnberg, Julia, Martínez, Alfredo, Serra-Majem, Lluís, Estruch, Ramon, Muñoz-Garach, Araceli, Lapetra, José, Pintó, Xavier, Tur, Josep, Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Bulló, Mónica, Sorli, Jose, Quifer, Mireia, Colom, Antoni, Oncina-Canovas, Alejandro, Tojal-Sierra, Lucas, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Sanchez-Villegas, Almudena, Casas, Rosa, Fernández-Garcia, José, Santos-Lozano, José, Corbella, Emili, del M. Bibiloni, Maria, Diez-Espino, Javier, Asensio, Eva, Torras, Laura, Matía Martín, María Del Pilar, Morey, Marga, Compañ-Gabucio, Laura, Salaverria-Lete, Itziar, Cenoz-Osinaga, Juan, Castañer, Olga, and Salas-Salvadó, Jordi

Abstract

Unión Europea. FP7, Instituto de Salud Carlos III (ISCIII) / FEDER, Instituto de Salud Carlos III (ISCIII) / FEDER, Instituto de Salud Carlos III (ISCIII) / FEDER, Junta de Andalucía, Generalitat Valenciana, Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2019

228. Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome

Author

Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-González, Miguel A., Bulló, Mónica, Corella, Dolores, Fitó, Montse, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluís, Estruch, Ramon, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomas, Nerea, Martinez-Lacruz, Raul, Schröder, Helmut, Konieczna, Jadwiga, Garcia-de-la-Hera, Manoli, Moreno-Rodriguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, José M., Trias, Ferran, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragan, Rocio, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefanía, Castañer, Olga, Salas-Salvadó, Jordi, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-González, Miguel A., Bulló, Mónica, Corella, Dolores, Fitó, Montse, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluís, Estruch, Ramon, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomas, Nerea, Martinez-Lacruz, Raul, Schröder, Helmut, Konieczna, Jadwiga, Garcia-de-la-Hera, Manoli, Moreno-Rodriguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, José M., Trias, Ferran, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragan, Rocio, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefanía, Castañer, Olga, and Salas-Salvadó, Jordi

Abstract

Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk., Unión Europea. FP7, Instituto de Salud Carlos III (ISCIII) / FEDER, Instituto de Salud Carlos III (ISCIII) / FEDER, Instituto de Salud Carlos III (ISCIII) / FEDER, Junta de Andalucía, Generalitat Valenciana, Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2019

229. Dietary Diversity and Nutritional Adequacy among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Pl us Study:A Cross-Sectional Analysis

Author

Medicina, Medikuntza, Cano Ibáñez, Naomi, Gea, Alfredo, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Zomeño Blanquerna, María Dolores, Romaguera, Dora, Vioque, Jesús, Arós Borau, Luis Fernando, Warnberg, Julia, Martínez, J. Alfredo, Serra Majem, Lluís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García Ríos, Antonio, Riquelme Gallego, Blanca, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil Cosiales, Pilar, Díaz López, Andrés, Fernández Carrión, Rebeca, Fitó, Montserrat, Konieczna, Jadwiga, Notario Barandiaran, Leyre, Alonso Gómez, Ángel María, Contreras Fernández, Eugenio, Abete, Itziar, Sánchez Villegas, Almudena, Casas, Rosa, Muñoz Garach, Araceli, Santos Lozano, José Manuel, Gallardo Alfaro, Laura, Basora, Josep, Portoles, Olga, Muñoz, Miguel Ángel, Moñino, Manuel, Miralles Gisbert, Salvador, Moreno Rodríguez, Anai, Ruiz Canela, Miguel, Palau Galindo, Antoni, Pérez Vega, Karla Alejandra, Bueno Cavanillas, Aurora, Medicina, Medikuntza, Cano Ibáñez, Naomi, Gea, Alfredo, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Zomeño Blanquerna, María Dolores, Romaguera, Dora, Vioque, Jesús, Arós Borau, Luis Fernando, Warnberg, Julia, Martínez, J. Alfredo, Serra Majem, Lluís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García Ríos, Antonio, Riquelme Gallego, Blanca, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil Cosiales, Pilar, Díaz López, Andrés, Fernández Carrión, Rebeca, Fitó, Montserrat, Konieczna, Jadwiga, Notario Barandiaran, Leyre, Alonso Gómez, Ángel María, Contreras Fernández, Eugenio, Abete, Itziar, Sánchez Villegas, Almudena, Casas, Rosa, Muñoz Garach, Araceli, Santos Lozano, José Manuel, Gallardo Alfaro, Laura, Basora, Josep, Portoles, Olga, Muñoz, Miguel Ángel, Moñino, Manuel, Miralles Gisbert, Salvador, Moreno Rodríguez, Anai, Ruiz Canela, Miguel, Palau Galindo, Antoni, Pérez Vega, Karla Alejandra, and Bueno Cavanillas, Aurora

Abstract

Dietary guidelines emphasize the importance of a varied diet to provide an adequate nutrient intake. However, an older age is often associated with consumption of monotonous diets that can be nutritionally inadequate, increasing the risk for the development or progression of diet-related chronic diseases, such as metabolic syndrome (MetS). To assess the association between dietary diversity (DD) and nutrient intake adequacy and to identify demographic variables associated with DD, we cross-sectionally analyzed baseline data from the PREDIMED-Plus trial: 6587 Spanish adults aged 55-75 years, with overweight/obesity who also had MetS. An energy-adjusted dietary diversity score (DDS) was calculated using a 143-item validated semi-quantitative food frequency questionnaire (FFQ). Nutrient inadequacy was defined as an intake below 2/3 of the dietary reference intake (DRI) forat least four of 17 nutrients proposed by the Institute of Medicine (IOM). Logistic regression models were used to evaluate the association between DDS and the risk of nutritionally inadequate intakes. In the higher DDS quartile there were more women and less current smokers. Compared with subjects in the highest DDS quartile, those in the lowest DDS quartile had a higher risk of inadequate nutrient intake: odds ratio (OR) = 28.56 (95% confidence interval (CI) 20.80-39.21). When we estimated food varietyfor each of the food groups, participants in the lowest quartile had a higher risk of inadequate nutrient intake for the groups of vegetables, OR = 14.03 (95% CI 10.55-18.65), fruits OR = 11.62 (95% CI 6.81-19.81), dairy products OR = 6.54 (95% CI 4.64-9.22) and protein foods OR = 6.60 (95% CI 1.96-22.24). As DDS decreased, the risk of inadequate nutrients intake rose. Given the impact of nutrient intake adequacy on the prevention of non-communicable diseases, health policies should focus on the promotion of a healthy varied diet, specifically promoting the intake of vegetables and fruit among populati

Published
2019

230. Nut Consumptions as a Marker of Higher Diet Quality in a Mediterranean Population at High Cardiovascular Risk

Author

Medicina, Medikuntza, Bibiloni, Maria del Mar, Julibert, Alicia, Bouzas, Cristina, Martínez González, Miguel Ángel, Corella, Dolores, Salas Salvadó, Jordi, Zomeño Blanquerna, María Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Tinahones, Francisco J., Serra Majem, Lluís, Martín, Vicente, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Ros, Emilio, Fernández Carrión, Rebeca, García Ríos, Antonio, Zulet, M. Ángeles, Orozco Beltrán, Domingo, Schröder, Helmut, Fitó, Montserrat, Bulló, Mónica, Basora, Josep, Cenoz, Juan Carlos, Díez Espino, Javier, Toledo, Estefanía, Tur, Josep A., Medicina, Medikuntza, Bibiloni, Maria del Mar, Julibert, Alicia, Bouzas, Cristina, Martínez González, Miguel Ángel, Corella, Dolores, Salas Salvadó, Jordi, Zomeño Blanquerna, María Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Tinahones, Francisco J., Serra Majem, Lluís, Martín, Vicente, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Ros, Emilio, Fernández Carrión, Rebeca, García Ríos, Antonio, Zulet, M. Ángeles, Orozco Beltrán, Domingo, Schröder, Helmut, Fitó, Montserrat, Bulló, Mónica, Basora, Josep, Cenoz, Juan Carlos, Díez Espino, Javier, Toledo, Estefanía, and Tur, Josep A.

Abstract

BACKGROUND: Nut consumption has been associated with improved nutrient adequacy and diet quality in healthy adult populations but this association has never been explored in individuals at high cardiovascular risk. OBJECTIVE: to assess the associations between consumption of nuts and nutrient adequacy and diet quality in a Mediterranean population at high cardiovascular risk. DESIGN: baseline assessment of nutritional adequacy in participants (n = 6060, men and women, with ages 55⁻75 years old, with overweight/obesity and metabolic syndrome) in the PREDIMED-PLUS primary cardiovascular prevention randomized trial. METHODS: nut intake was assessed using a validated food frequency questionnaire. Participants who reported consuming zero quantity of nuts were classified as 'non-nut consumers'. 'Nut consumers' were participants who reported consuming any quantity of nuts. Nineteen micronutrients were examined (vitamins B1, B2, B3, B6, B12, A, C, D, E and folic acid; Ca, K, P, Mg, Fe, Se, Cr, Zn, and iodine). The proportion of micronutrient inadequacy was estimated using the estimated average requirements (EAR) or adequate intake (AI) cut-points. Diet quality was also assessed using a 17-item Mediterranean dietary questionnaire (Mediterranean diet score, MDS), a carbohydrate quality index (CQI) and a fat quality index (FQI). RESULTS: eighty-two percent of participants were nut consumers (median of nut consumption 12.6 g/day; interquartile range: 6.0⁻25.2). Nut consumers were less likely to be below the EAR for vitamins A, B1, B2, B6, C, D, E, folic acid, and Ca, Mg, Se and Zn than non-nut consumers. Nut consumers were also more likely to be above the AI for K and Cr than non-nut consumers. Nut consumers had lower prevalence of inadequate micronutrient intakes, but also higher CQI, higher FQI, and better scores of adherence to the Mediterranean diet (Mediterranean diet score, MDS). CONCLUSIONS: nut consumers had better nutrient adequacy, diet quality, and adherence to the M

Published
2019

231. Dietary Diversity and Nutritional Adequacy among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Author

Universidad de Sevilla. Departamento de Medicina, Cano-Ibáñez, Naomi, Gea, Alfredo, Martínez-González, Miguel A., Salas-Salvadó, Jordi, Corella, Dolores, Zomeño, M. Dolors, Santos Lozano, José Manuel, Bueno-Cavanillas, Aurora, Universidad de Sevilla. Departamento de Medicina, Cano-Ibáñez, Naomi, Gea, Alfredo, Martínez-González, Miguel A., Salas-Salvadó, Jordi, Corella, Dolores, Zomeño, M. Dolors, Santos Lozano, José Manuel, and Bueno-Cavanillas, Aurora

Abstract

Dietary guidelines emphasize the importance of a varied diet to provide an adequate nutrient intake. However, an older age is often associated with consumption of monotonous diets that can be nutritionally inadequate, increasing the risk for the development or progression of diet-related chronic diseases, such as metabolic syndrome (MetS). To assess the association between dietary diversity (DD) and nutrient intake adequacy and to identify demographic variables associated with DD, we cross-sectionally analyzed baseline data from the PREDIMED-Plus trial: 6587 Spanish adults aged 55–75 years, with overweight/obesity who also had MetS. An energy-adjusted dietary diversity score (DDS) was calculated using a 143-item validated semi-quantitative food frequency questionnaire (FFQ). Nutrient inadequacy was defined as an intake below 2/3 of the dietary reference intake (DRI) forat least four of 17 nutrients proposed by the Institute of Medicine (IOM). Logistic regression models were used to evaluate the association between DDS and the risk of nutritionally inadequate intakes. In the higher DDS quartile there were more women and less current smokers. Compared with subjects in the highest DDS quartile, those in the lowest DDS quartile had a higher risk of inadequate nutrient intake: odds ratio (OR) = 28.56 (95% confidence interval (CI) 20.80–39.21). When we estimated food varietyfor each of the food groups, participants in the lowest quartile had a higher risk of inadequate nutrient intake for the groups of vegetables, OR = 14.03 (95% CI 10.55–18.65), fruits OR = 11.62 (95% CI 6.81–19.81), dairy products OR = 6.54 (95% CI 4.64–9.22) and protein foods OR = 6.60 (95% CI 1.96–22.24). As DDS decreased, the risk of inadequate nutrients intake rose. Given the impact of nutrient intake adequacy on the prevention of non-communicable diseases, health policies should focus on the promotion of a healthy varied diet, specifically promoting the intake of vegetables and fruit among populati

Published
2019

232. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic SyndromeInterim Analysis of the PREDIMED-Plus Randomized Clinical Trial

Author

European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, Martínez-González, Miguel Ángel, European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, and Martínez-González, Miguel Ángel

Abstract

[Importance] High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on dietary changes., [Objective] To assess the effect of a nutritional and physical activity education program on dietary quality., [Design, Setting, and Participants] Preliminary exploratory interim analysis of an ongoing randomized trial. In 23 research centers in Spain, 6874 men and women aged 55 to 75 years with metabolic syndrome and no cardiovascular disease were enrolled in the trial between September 2013 and December 2016, with final data collection in March 2019., [Interventions] Participants were randomized to an intervention group that encouraged an energy-reduced Mediterranean diet, promoted physical activity, and provided behavioral support (n = 3406) or to a control group that encouraged an energy-unrestricted Mediterranean diet (n = 3468). All participants received allotments of extra-virgin olive oil (1 L/mo) and nuts (125 g/mo) for free., [Main Outcomes and Measures] The primary outcome was 12-month change in adherence based on the energy-reduced Mediterranean diet (er-MedDiet) score (range, 0-17; higher scores indicate greater adherence; minimal clinically important difference, 1 point)., [Results] Among 6874 randomized participants (mean [SD] age, 65.0 [4.9] years; 3406 [52%] men), 6583 (96%) completed the 12-month follow-up and were included in the main analysis. The mean (SD) er-MedDiet score was 8.5 (2.6) at baseline and 13.2 (2.7) at 12 months in the intervention group (increase, 4.7 [95% CI, 4.6-4.8]) and 8.6 (2.7) at baseline and 11.1 (2.8) at 12 months in the control group (increase, 2.5 [95% CI, 2.3-2.6]) (between-group difference, 2.2 [95% CI, 2.1-2.4]; P < .001)., [Conclusions and Relevance] In this preliminary analysis of an ongoing trial, an intervention that encouraged an energy-reduced Mediterranean diet and physical activity, compared with advice to follow an energy-unrestricted Mediterranean diet, resulted in a significantly greater increase in diet adherence after 12 months. Further evaluation of long-term cardiovascular effects is needed., [Trial Registration] isrctn.com Identifier: ISRCTN89898870.

Published
2019

233. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Author

Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, and Salas-Salvadó, Jordi

Abstract

[Purpose]: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome. [Methods]:A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively., [Results]: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82–0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84–0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence., [Conclusions]: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.

Published
2019

234. Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome

Author

Instituto de Salud Carlos III, European Commission, European Research Council, Fundación la Caixa, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundació Institut d'Investigació Sanitària Illes Balears, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-García, Miguel Ángel, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomás, Nerea, Martínez-Lacruz, Raúl, Schröder, Helmut, Konieczna, Jadwiga, García-de-la-Hera, Manoli, Moreno-Rodríguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, J. M., Trias, Ferrán, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragán, Rocío, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefania, Castañer, Olga, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Fundación la Caixa, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundació Institut d'Investigació Sanitària Illes Balears, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-García, Miguel Ángel, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomás, Nerea, Martínez-Lacruz, Raúl, Schröder, Helmut, Konieczna, Jadwiga, García-de-la-Hera, Manoli, Moreno-Rodríguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, J. M., Trias, Ferrán, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragán, Rocío, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefania, Castañer, Olga, and Salas-Salvadó, Jordi

Abstract

Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. Significant positive associations with BMI and WC were found in those participants napping ≥30 min as compared to those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk.

Published
2019

236. One-year changes in fruit and vegetable variety intake and cardiometabolic risk factors changes in a middle-aged Mediterranean population at high cardiovascular risk

Author

López-González, Leyre, Becerra-Tomás, Nerea, Babio, Nancy, Martínez-González, Miguel Ángel, Nishi, Stephanie K., Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Vázquez-Ruiz, Zenaida, Martín-Luján, Francisco M., Sorlí, José V., Castañer, Olga, Zulet, M. Angeles, Tojal-Sierra, Lucas, Carabaño-Moral, Rosa, Román-Maciá, Josefa, Rayó, Elena, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana M., Santos-Lozano, José M., Buil-Cosiales, Pilar, Asensio, Eva M., Lassale, Camille, Abete, Itziar, Salaverria-Lete, Itziar, Sayón-Orea, Carmen, Schröder, Helmut, and Salas-Salvadó, Jordi

Abstract

Background and aims: Previous studies have shown beneficial associations between fruit and vegetable (FV) consumption and cardiometabolic risk factors. However, variety in FV, which may play an important role on cardiovascular health due to the different nutrient and phytochemical content among the different groups and subgroups of FV has been poorly investigated. We longitudinally investigated associations between 1-year changes in variety and quantity of FV and concurrent changes in cardiometabolic risk factors in elderly subjects with overweight/obesity and metabolic syndrome. Methods: a one-year data longitudinal analysis of 6647 PREDIMED-plus study participants (48% women) was conducted. Data were collected at baseline, six months and 1-year of follow-up. Variety and quantity of FV were estimated using a food frequency questionnaire and continuous scores for variety were created based on items/month of FV. Linear mixed-models adjusted for potential confounders were performed to estimate associations (β-coefficients and 95% confidence interval) between 1-year changes in FV variety and/or quantity and concurrent changes in cardiometabolic risk factors. Results: Two points increment in the FV variety score over one year was associated with a concurrent decrease in glucose (−0.33 mg/dL (0.58, −0.07)), body weight (−0.07 kg (−0.13, −0.02)) and waist circumference (WC) (−0.08 cm (−0.16, −10.01)). An increment of 100 g/d of FV over one year was associated with a concurrent decrease in triglycerides (−0.50 mg/dL (−0.93, −0.08)), glucose (−0.21 mg/dL (−0.32, −0.11)), body weight (−0.11 kg (−0.15, −0.07)) and WC (−0.10 cm (−0.14, −0.06)) over 1-year. Changes in FV consumption which led to higher quantity and variety over one year were associated with downward changes in glucose (−1.26 mg/dL (−2.09, −0.43)), body weight (−0.40 kg (−0.58, −0.23)) and WC (−0.50 cm (−0.73, −0.28)). Conclusion: Greater variety, in combination with higher quantity of FV was significantly associated with a decrease in several cardiometabolic risk factors among elderly subjects at high cardiovascular risk.

Published
2022
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237. Baseline drinking water consumption and changes in body weight and waist circumference at 2-years of follow-up in a senior Mediterranean population.

Author

Paz-Graniel, Indira, Becerra-Tomás, Nerea, Babio, Nancy, Serra-Majem, Lluís, Vioque, Jesús, Zomeño, María Dolors, Corella, Dolores, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Daimiel, Lidia, Zulet, M. Angeles, Palau-Galindo, Antoni, Torres-Collado, Laura, Schröder, Helmut, Gimenez-Alba, Ignacio Manuel, Nissenshon, Mariela, Galera, Ana, Riquelme-Gallego, Blanca, and Bouzas, Cristina

Abstract

The association between drinking water consumption and adiposity has been poorly explored. Therefore, we aimed to analyse the associations between the frequency of drinking water consumption and body weight and waist circumference changes in an elderly Mediterranean cohort. A total of 1832 elderly participants (aged 55–75 years) with metabolic syndrome from the PREDIMED-Plus study with baseline data on drinking water and other beverages assessed by a validated 32-item Spanish fluid-intake questionnaire and with data on body weight (BW) and waist circumference (WC) at 1-year and 2-year were included in these prospective analyses. Multivariable linear regression models were fitted to assess the β-coefficients and 95% confidence interval (CI) for BW and WC changes in terms of categories of baseline drinking water consumption (tap water and bottled water). The theoretical effect on BW and WC of replacing several beverages with drinking water was assessed using mathematical models. The baseline frequency of drinking water consumption was inversely associated with 1-year and 2-year changes in BW. β-coefficients (95%CI) across categories of water consumption (<2.5, 2.5 to <5, 5 to < 7.5, ≥7.5 servings/d) expressed in % of weight changes at 2 years of follow-up were 0.0, −0.80 (−1.48, −0.12), −1.36 (−2.18, −0.54), and −1.97 (−3.09, −0.86), respectively. Individuals in the two highest categories of drinking water consumption (5 to < 7, and ≥7.5 servings/d) also showed a higher decrease in WC (expressed as % of change) after 2 years of follow-up: −1.11 (−1.96, −0.25) and −1.45 (−2.66, −0.24) compared to the reference intake (<2.5 servings/day), after adjustment for potential confounding factors. The theoretical replacement of soups, beers, spirits, hot beverages, dairy beverages, and other beverages group with drinking water was associated with greater reductions in BW at one- and two-years of follow-up. Drinking water consumption was inversely associated with 2-year adiposity changes in an elderly Mediterranean cohort at high cardiovascular risk. Our results also suggest that the consumption of drinking water instead of energy-containing beverages is associated with lower weight gain. ISRCTN89898870. • Drinking water consumption was inversely associated with 1-year and 2-year changes in BW. • Increased drinking water was associated with higher reduction in waist circumference. • The replacement of some energy containing beverages consumption by drinking water was associated with reductions on BW. • Replacement of 1 mixed alcoholic beverage serving by 1 drinking water serving was associated with reductions on BW. [ABSTRACT FROM AUTHOR]

Published
2021
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238. Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study.

Author

Glenn, Andrea J., Hernández-Alonso, Pablo, Kendall, Cyril W.C., Martínez-González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Martínez, J.Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Celada, Sofia Reguero, and Pintó, Xavier

Abstract

The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors. After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence. Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction. [ABSTRACT FROM AUTHOR]

Published
2021
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239. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome.

Author

Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., and Sánchez, Vicente Martín

Subjects
METABOLIC syndrome, HEALTH of older people, CAFFEINE, COMORBIDITY, GLOMERULAR filtration rate, CHRONIC kidney failure
Abstract

It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS. [ABSTRACT FROM AUTHOR]

Published
2021
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240. Variety in fruits and vegetables, diet quality and lifestyle in an older adult mediterranean population.

Author

López-González, Leyre, Becerra-Tomás, Nerea, Babio, Nancy, Martínez-González, Miguel Ángel, Díaz-López, Andrés, Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco, Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, and Bueno-Cavanillas, Aurora

Abstract

Previous studies, mainly focused on quantity rather than variety, have shown beneficial associations between the amount of fruit and vegetable consumed, diet quality and healthy lifestyle. The aim is to evaluate the association between fruit and vegetable consumption, diet quality and lifestyle in an elderly Mediterranean population, considering both variety and the combination of quantity and variety (QV). A cross-sectional analysis of 6647 participants (51.6% of males) was conducted in the framework of the PREDIMED-Plus study. A variety score was created as the sum of vegetables and/or fruits consumed at least once per month using food frequency questionnaires. Dietary Reference Intakes (EAR and IA values) were used to estimate the prevalence of inadequate intake of dietary fiber and micronutrients. Logistic regression models were performed to examine the association between fruit and vegetable consumption and not meeting the DRIs, by tertiles of fruit and vegetable variety and QV categories. Participants with higher fruit and vegetable variety score reported a significant higher intake of fiber, vitamins, minerals and flavonoids and were significantly more likely to be physically active and non-smoker. Besides, higher variety in fruit and vegetable consumption was associated with lower prevalence of having an inadequate intake of fiber [(0.13 (0.11–0.16)], two or more [(0.17 (0.14–0.21)], three or more [(0.15 (0.13–0.18)] and four or more [(0.11 (0.10–0.14)] micronutrients in our participants. Higher quantity and variety in fruit and vegetable consumption was associated with lower prevalence of having an inadequate intake of fiber [(0.05 (0.04–0.06)], two or more [(0.08 (0.06–0.10)], three or more [(0.08 (0.06–0.09)] and four or more [(0.06 (0.05–0.07)] micronutrients. Greater variety in fruit and vegetable intake was associated with better nutrient adequacy, diet quality and healthier lifestyle in an elderly Mediterranean population. [ABSTRACT FROM AUTHOR]

Published
2021
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241. Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial.

Author

Muñoz‐Garach, Araceli, Cornejo‐Pareja, Isabel, Martínez‐González, Miguel Ángel, Bulló, Monica, Corella, Dolores, Castañer, Olga, Romaguera, Dora, Vioque, Jesús, Alonso‐Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra‐Majem, Luís, Estruch, Ramon, Bernal‐López, M. Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A., López‐Miranda, José, Bueno‐Cavanillas, Aurora, and Delgado‐Rodríguez, Miguel

Published
2021
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243. Procedimiento y sistema para la asociación diferencial de dispositivos inalámbricos

Author

Bueno Cavanillas, Aurora, Díaz García, Antonio Francisco, Lardelli Claret, Pablo, and Díaz García, Juan

Subjects
Esquemas de pago, Transacciones de pagos, Tarjeta de identidad codificada, G07F 7/08, G06Q 20/00
Abstract

Número de publicación: ES2591052 B1. Número de solicitud: 201500311. Solicitud internacional: PCT/ES2016/070296, La presente invención consiste en un procedimiento que permite detectar y diferenciar dispositivos inalámbricos y móviles que se encuentran en un espacio concreto durante un tiempo determinado, tras la generación de un evento. También se describe un sistema que implementa dicho procedimiento., Universidad de Granada, Servicio Andaluz de Salud

Published
2017

244. Asociación entre índice tobillo-brazo y rendimiento cognitivo en participantes del estudio PREDIMED-Plus: estudio transversal

Author

López, Meritxell, Ríos, Angel, Romaguera, Dora, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Vioque, Jesús, Alonso-Gómez, Ángel M., Crespo-Oliva, Edelys, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García-Ríos, Antonio, Bueno-Cavanillas, Aurora, Gaforio, José J., Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Sanz-Martínez, Enrique, Ros, Emilio, Toledo, Estefanía, Barrubés, Laura, Barragán, Rocío, de la Torre, Rafael, Fiol, Miquel, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Martín-Ruiz, María Victoria, Zulet, María Ángeles, Díaz-Collado, Fátima, Casas, Rosa, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Mallorqui-Bagué, Nuria, Argelich, Emma, Lecea, Óscar, Paz-Graniel, Indira, Sorlí, José V., Cuenca, Aida, Munuera, Susana, Hernándis-Marsán, María Vicenta, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Camacho-Barcia, Lucía, Jiménez-Murcia, Susana, Castañer, Olga, and Yáñez, Aina M.

Abstract

El índice tobillo-brazo (ITB) es un indicador de enfermedad arterial periférica (EAP). El objetivo de este estudio es evaluar la asociación entre la EAP medida con el ITB y el rendimiento cognitivo de individuos con sobrepeso u obesidad y síndrome metabólico.

Published
2021
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245. Nut Consumptions as a Marker of Higher Diet Quality in a Mediterranean Population at High Cardiovascular Risk

Author

Bibiloni, Maria, primary, Julibert, Alicia, additional, Bouzas, Cristina, additional, Martínez-González, Miguel, additional, Corella, Dolores, additional, Salas-Salvadó, Jordi, additional, Zomeño, M., additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Martínez, J., additional, Wärnberg, Julia, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Bueno-Cavanillas, Aurora, additional, Arós, Fernando, additional, Tinahones, Francisco, additional, Serra-Majem, Lluis, additional, Martín, Vicente, additional, Lapetra, José, additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Ros, Emilio, additional, Fernández-Carrión, Rebeca, additional, Garcia-Rios, Antonio, additional, Zulet, M., additional, Orozco-Beltrán, Domingo, additional, Schröder, Helmut, additional, Fitó, Montserrat, additional, Bulló, Mónica, additional, Basora, Josep, additional, Cenoz, Juan, additional, Diez-Espino, Javier, additional, Toledo, Estefanía, additional, and Tur, Josep, additional

Published
2019
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249. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study.

Author

Navarrete-Muñoz, Eva-Maria, Vioque, Jesus, Toledo, Estefanía, Oncina-Canovas, Alejando, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, and Bueno-Cavanillas, Aurora

Subjects
THERAPEUTIC use of folic acid, METABOLIC syndrome risk factors, REDUCING diets, CARDIOVASCULAR diseases risk factors, TRIGLYCERIDES, MEDITERRANEAN diet, CONFIDENCE intervals, CROSS-sectional method, INGESTION, BLOOD sugar, REGRESSION analysis, RISK assessment, PREPROCEDURAL fasting, QUESTIONNAIRES, DESCRIPTIVE statistics, FOLIC acid, HIGH density lipoproteins, PATIENT compliance, OLD age
Abstract

Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects. [ABSTRACT FROM AUTHOR]

Published
2021
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250. Quality and reporting of clinical guidelines for breast cancer treatment: A systematic review.

Author

Maes-Carballo, Marta, Mignini, Luciano, Martín-Díaz, Manuel, Bueno-Cavanillas, Aurora, and Khan, Khalid Saeed

Subjects
META-analysis, BREAST cancer, CANCER treatment, BIBLIOGRAPHIC databases, GUIDELINES
Abstract

High-quality, well-reported clinical practice guidelines (CPGs) and consensus statements (CSs) underpinned by systematic reviews are needed. We appraised the quality and reporting of CPGs and CSs for breast cancer (BC) treatment. Following protocol registration (Prospero no: CRD42020164801), CPGs and CSs on BC treatment were identified, without language restrictions, through a systematic search of bibliographic databases (MEDLINE, EMBASE, Web of Science, Scopus, CDSR) and online sources (12 guideline databases and 51 professional society websites) from January 2017 to June 2020. Data were extracted in duplicate assessing overall quality using AGREE II (% of maximum score) and reporting compliance using RIGHT (% of total 35 items); reviewer agreement was 98% and 96% respectively. There were 59 relevant guidance documents (43 CPGs, 16 CSs), of which 20 used systematic reviews for evidence synthesis. The median overall quality was 54.0% (IQR 35.9–74.3) and the median overall reporting compliance was 60.9% (IQR 44.5–84.4). The correlation between quality and reporting was 0.9. Compared to CSs, CPGs had better quality (55.4% vs 44.2%; p = 0.032) and reporting (67.18% vs 44.5%; p = 0.005). Compared to subjective methods of evidence analysis, guidance documents that used systematic reviews had better quality (76.3% vs 51.4%; p = 0.001) and reporting (87.1% vs 59.4%; p = 0.001). The quality and reporting of CPGs and CSs in BC treatment were moderately strong. Systematic reviews should be used to improve the quality and reporting of CPGs and CSs. • CPGs and CSs for BC treatment insufficiently followed quality and reporting assessment tools. • Systematic reviews should be used to improve the quality and reporting of CPGs and CSs. • AGREE II and RIGHT should be used to produce high-quality guidances to ensure trustworthy recommendations. [ABSTRACT FROM AUTHOR]

Published
2020
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