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207. Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness

Author

Morrell, Eric D., primary, Bhatraju, Pavan K., additional, Sathe, Neha A., additional, Lawson, Jonathan, additional, Mabrey, Linzee, additional, Holton, Sarah E., additional, Presnell, Scott R., additional, Wiedeman, Alice, additional, Acosta-Vega, Carolina, additional, Mitchem, Mallorie A., additional, Liu, Ted, additional, Chai, Xin-Ya, additional, Sahi, Sharon, additional, Brager, Carolyn, additional, Orlov, Marika, additional, Sakr, Sana S., additional, Sader, Anthony, additional, Lum, Dawn M., additional, Koetje, Neall, additional, Garay, Ashley, additional, Barnes, Elizabeth, additional, Cromer, Gail, additional, Bray, Mary K., additional, Pipavath, Sudhakar, additional, Fink, Susan L., additional, Evans, Laura, additional, Long, S. Alice, additional, West, T. Eoin, additional, Wurfel, Mark M., additional, and Mikacenic, Carmen, additional

Published
2022
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209. Intrafascicular Vagal Activity Recording and Analysis Based on Carbon Nanotube Yarn Electrodes

Author

Yu Xiao, Wang Jiaojiao, Arranz Javier, Chai Xin-yu, Guo Jinyao, Sui Xiaohong, and Wang Ji-guang

Subjects
0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary, Materials science, Electrode, Sensory system, Carbon nanotube yarn, 030217 neurology & neurosurgery, Neuromodulation (medicine), 030304 developmental biology, Biomedical engineering, Vagus nerve
Abstract

The vagus nerve carries sensory information from multiple organs in the body. The recording of its activity and further processing is a key step for neuromodulation treatments. This paper presents a specific algorithm for the processing and discrimination of intrafascicular recordings from the vagus nerve using the novel carbon nanotube yarn electrodes. Up to four different neural waveforms were found, whose occurrence corresponded to distinct levels of anesthesia depth.

Published
2020
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210. The Fulminating Course of Infection Caused by Shewanella algae: A Case Report

Author

Yan,Yun, Chai,Xin, Chen,Yu, and Zhang,Xijing

Subjects
Infection and Drug Resistance, bacteria
Abstract

Yun Yan, Xin Chai, Yu Chen, Xijing Zhang Department of Critical Care Medicine, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of ChinaCorrespondence: Yu Chen; Xijing Zhang, Department of Critical Care Medicine, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China, Tel +862984775344, Fax +862983244986, Email chenyu007@gmail.com; xjzhang0806@163.comAbstract: Shewanella algae, a Gram-negative bacillus found in warm saltwater environments, has been increasingly recognized as a human pathogen that can cause infection of the skin and soft tissue, ear, blood, and intra-abdominal. In this case, we report a Shewanella algae infection that caused sepsis, renal insufficiency, cardiac dysfunction, fistula and massive pleural effusion after surgery in a 73-year-old man with cancer of the esophagus and cardia.Keywords: Shewanella species, Shewanella algae, fulminating course, malignancy, sepsis

Published
2022

220. CXCL10 and Soluble Programmed Death-Ligand 1 during Respiratory Viral Infections Are Associated with Chronic Lung Allograft Dysfunction in Lung Transplant Recipients

Author

Morrell, Eric D., primary, Brager, Carolyn, additional, Ramos, Kathleen J., additional, Chai, Xin-Ya, additional, Kapnadak, Siddhartha G., additional, Edelman, Jeffrey, additional, Matute-Bello, Gustavo, additional, Altemeier, William A., additional, Hwang, Billanna, additional, Mulligan, Michael S., additional, Bhatraju, Pavan K., additional, Wurfel, Mark M., additional, Mikacenic, Carmen, additional, Lease, Erika D., additional, Limaye, Ajit P., additional, and Fisher, Cynthia E., additional

Published
2022
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226. Chemical proteomics reveals an ISR‐like response elicited by salicylic acid in Arabidopsis.

Author

Li, Xin, Chai, Xin, Lyu, Hai‐Ning, Fu, Chunjin, Tang, Huan, Shi, Qiaoli, Wang, Jigang, and Xu, Chengchao

Subjects
*SALICYLIC acid, *PROTEOMICS, *DNA-binding proteins, *ARABIDOPSIS proteins, *ARABIDOPSIS, *BOTANY
Abstract

S2 Salicylic acid (SA) suppresses new protein synthesis in wild-type (WT) and npr1-1 mutants. Keywords: chemical proteomics; integrated stress response; plant immunity; salicylic acid (SA); salicylic acid-binding proteins EN chemical proteomics integrated stress response plant immunity salicylic acid (SA) salicylic acid-binding proteins 1486 1489 4 02/06/23 20230301 NES 230301 Higher plants rely on the hypersensitive response, an immune response that triggers rapid cell death, to prevent the spread of infecting pathogens (Pennazio, [14]). Chemical proteomics reveals an ISR-like response elicited by salicylic acid in Arabidopsis Chemical proteomics, plant immunity, integrated stress response, salicylic acid-binding proteins, salicylic acid (SA). [Extracted from the article]

Published
2023
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233. The Feasibility and Safety of Cocktail Treatment of Triple Anti-Inflammatory Agents Loaded with Gelatin Sponge Promotes Early Recovery After Posterior Percutaneous Endoscopic Cervical Discectomy

Author

Zou, Peng, primary, Zhang, Xiaoping, additional, Zhang, Rui, additional, Yang, Jun-Song, additional, Chu, Lei, additional, Wang, Xiang-Fu, additional, Wei, Jian-Min, additional, Chai, Xin, additional, Zhao, Yuan-Ting, additional, and Liao, Bo, additional

Published
2022
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234. Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2

Author

Chai, Xin, primary, Sun, Huiyong, additional, Zhou, Wenfang, additional, Chen, Changwei, additional, Shan, Luhu, additional, Yang, Yuhui, additional, He, Junzhao, additional, Pang, Jinping, additional, Yang, Liu, additional, Wang, Xinyue, additional, Cui, Sunliang, additional, Fu, Yaqin, additional, Xu, Xiaohong, additional, Xu, Lei, additional, Yao, Xiaojun, additional, Li, Dan, additional, and Hou, Tingjun, additional

Published
2022
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238. Potential value and chemical characterization of gut microbiota derived nitrogen containing metabolites in feces from Periplaneta americana (L.) at different growth stages

Author

Yuefei Wang, Weiqi Lv, Ying Cui, Wang Ziyan, Niu Lu, Chai Xin, and Gen Xue

Subjects
Nymph, animal structures, Nitrogen, media_common.quotation_subject, Science, Carboxylic Acids, Cockroaches, Insect, Gut flora, Biochemistry, Article, Feces, Animals, Food science, media_common, Biological Products, Multidisciplinary, biology, Drug discovery, fungi, Biological activity, biology.organism_classification, Isoquinolines, Computational biology and bioinformatics, Gastrointestinal Microbiome, Medicine, PEST analysis, American cockroach, Zoology, Periplaneta
Abstract

The American cockroach, Periplaneta americana (L.), is able to highly survive in various complicated environments around the globe, and often considered as a pest. In contrast, billions of P. americana have been massively reared in China and extensively used as a medicinal insect, due to its function for preventing and treating ulceration and heart failure. Considering the possibility that microbiota-derived metabolites could be an effective source to identify promising candidate drugs, we attempted to establish a rapid method for simultaneous determination of gut microbiota metabolites from medicinal insects. In this study, network pharmacology approach and ultra-performance liquid chromatography (UPLC) technique were employed to reveal the potential pharmacological activity and dynamics variation of nitrogen-containing metabolites (NCMs) originated from the gut microbiota of breeding P. americana at different growth stages. A metabolites-targets-diseases network showed that NCMs are likely to treat diseases such as ulceration and cancer. The analysis of NCMs' content with the growth pattern of P. americana indicated that the content of NCMs declined with P. americana aging. Both principal component analysis and orthogonal partial least squares discriminant analysis suggested that 8-hydroxy-2-quinolinecarboxylic acid and 8-hydroxy-3,4-dihydro-2(1H)-quinolinone are the potential differential metabolic markers for discriminating between nymphs and adults of P. americana. Moreover, the developed UPLC method showed an excellent linearity (R2 > 0.999), repeatability (RSD P. americana.

Published
2021

243. The implementation of enhanced recovery after surgery pathway in patients undergoing posterior thoracolumbar fusion for degenerative spinal deformity.

Author

Yuan, Yi, Wang, Shuai-Kang, Chai, Xin-Yi, Wang, Peng, Li, Xiang-Yu, Kong, Chao, and Lu, Shi-Bao

Subjects
ENHANCED recovery after surgery protocol, SPINAL surgery, SPINE abnormalities, SPINAL fusion, SURGICAL site infections, URINARY catheters
Abstract

Purpose: The prevalence of degenerative spinal deformity (DSD) and the increased cost of correction surgery impose substantial burdens on the health care and insurance system. The aim of our study was to investigate the effects of the implementation of Enhanced Recovery After Surgery (ERAS) protocol on postoperative outcomes after complex spinal surgery. Methods: A retrospective analysis of prospectively established database of DSD was performed. The consecutive patients who underwent open correction surgery for degenerative spinal deformity between August 2016 and February 2022 were reviewed. We extracted demographic data, preoperative radiographic parameters, and surgery-related variables. The ERAS patients were 1:1 propensity-score matched to a historical cohort by the same surgical team based on age, gender, BMI, and number of levels fused. We then compared the length of hospital stay (LOS), physiological functional recovery, and the rates of complications and readmissions within 90 days after surgery between the groups. Results: There were 108 patients included, 54 patients in the ERAS cohort, and 54 patients matched control patients in the historical cohort. The historical and ERAS cohorts were not significantly different regarding demographic characteristics, comorbidities, preoperative parameters, operative time, and reoperation rate (P > 0.05). Patients in the ERAS group had significantly shorter postoperative LOS (12.0 days vs. 15.1 days, P = 0.001), average days of drain and urinary catheters placement (3.5 days vs. 4.4 days and 1.9 days vs 4.8 days, respectively), and lower 90-day readmission rate (1.8% vs. 12.9%, P = 0.027). The first day of assisted-walking and bowel movement occurred on average 1.9 days (2.5 days vs. 4.4 days, P = 0.001) and 1.7 days (1.9 days vs. 3.6 days, P = 0.001) earlier respectively in the ERAS group. Moreover, the rate of postoperative urinary retention (3.7% vs. 16.7%, P = 0.026) and surgical site infection (0% vs. 7.4%, P = 0.046) were significantly lower with ERAS protocol applied. Conclusions: Our study confirmed that the ERAS protocol was safe and essential for patients undergoing thoracolumbar deformity surgery for DSD. The ERAS protocol was associated with a shorter postoperative LOS, a lower rate of 90-day readmission, less rehabilitation discharge, and less postoperative complications. [ABSTRACT FROM AUTHOR]

Published
2023
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246. Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis

Author

Hu, Xueping, primary, Pang, Jinping, additional, Zhang, Jintu, additional, Shen, Chao, additional, Chai, Xin, additional, Wang, Ercheng, additional, Chen, Haiyi, additional, Wang, Xuwen, additional, Duan, Mojie, additional, Fu, Weitao, additional, Xu, Lei, additional, Kang, Yu, additional, Li, Dan, additional, Xia, Hongguang, additional, and Hou, Tingjun, additional

Published
2021
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247. Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers

Author

Fu, Weitao, primary, Zhang, Minkui, additional, Liao, Jianing, additional, Tang, Qing, additional, Lei, Yixuan, additional, Gong, Zhou, additional, Shan, Luhu, additional, Duan, Mojie, additional, Chai, Xin, additional, Pang, Jinping, additional, Tang, Chun, additional, Wang, Xuwen, additional, Xu, Xiaohong, additional, Li, Dan, additional, Sheng, Rong, additional, and Hou, Tingjun, additional

Published
2021
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