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3,102 results on '"Cerhan, James R."'

201. Primary Prevention of Cancer

Author

Thun, Michael J., primary, Linet, Martha S., additional, Cerhan, James R., additional, Haiman, Christopher, additional, and Schottenfeld, David, additional

Published
2017
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204. Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Author

McMaster, Mary L., Berndt, Sonja I., Zhang, Jianqing, Slager, Susan L., Li, Shengchao Alfred, Vajdic, Claire M., Smedby, Karin E., Yan, Huihuang, Birmann, Brenda M., Brown, Elizabeth E., Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M., Mayr, Christine, Zhu, Bin, Chung, Charles C., Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D., Hutchinson, Amy, Teras, Lauren R., Adami, Hans-Olov, Bracci, Paige M., McKay, James, Monnereau, Alain, Link, Brian K., Vermeulen, Roel C. H., Ansell, Stephen M., Maria, Ann, Diver, W. Ryan, Melbye, Mads, Ojesina, Akinyemi I., Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M., Canzian, Federico, Travis, Ruth C., Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolaus, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacques, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L., Novak, Anne J., Lawrence, Charles, Bassig, Bryan A., Lan, Qing, Zheng, Tongzhang, North, Kari E., Tinker, Lesley F., Cozen, Wendy, Severson, Richard K., Hofmann, Jonathan N., Zhang, Yawei, Jackson, Rebecca D., Morton, Lindsay M., Purdue, Mark P., Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R., Skibola, Christine F., and Caporaso, Neil E.

Published
2018
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207. History of autoimmune conditions and lymphoma prognosis

Author

Kleinstern, Geffen, Maurer, Matthew J., Liebow, Mark, Habermann, Thomas M., Koff, Jean L., Allmer, Cristine, Witzig, Thomas E., Nowakowski, Grzegorz S., Micallef, Ivana N., Johnston, Patrick B., Inwards, David J., Thompson, Carrie A., Feldman, Andrew L., Link, Brian K., Flowers, Christopher, Slager, Susan L., and Cerhan, James R.

Published
2018
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210. Revised MALT‐IPI: A new predictive model that identifies high‐risk patients with extranodal marginal zone lymphoma

Author

Alderuccio, Juan Pablo, primary, Reis, Isildinha M., additional, Habermann, Thomas M., additional, Link, Brian K., additional, Thieblemont, Catherine, additional, Conconi, Annarita, additional, Larson, Melissa C., additional, Cascione, Luciano, additional, Zhao, Wei, additional, Cerhan, James R., additional, Zucca, Emanuele, additional, and Lossos, Izidore S., additional

Published
2022
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211. Physical activity and the risk of non‐Hodgkin lymphoma subtypes: A pooled analysis

Author

Boyle, Terry, primary, Kleinstern, Geffen, additional, Bracci, Paige M., additional, Cerhan, James R., additional, Benavente, Yolanda, additional, Casabonne, Delphine, additional, Chiu, Brian C.‐H., additional, Habermann, Thomas M., additional, Holly, Elizabeth A., additional, Liebow, Mark, additional, Norman, Aaron, additional, Paltiel, Ora, additional, Robinson, Dennis, additional, Rothman, Nathaniel, additional, Abu Seir, Rania, additional, Slager, Susan L., additional, Villeneuve, Paul J., additional, Wang, Sophia S., additional, Weisenburger, Dennis D., additional, and Spinelli, John J., additional

Published
2022
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212. Patient Experience in Clinical Trials: Quality of Life, Financial Burden, and Perception of Care in Patients With Multiple Myeloma or Lymphoma Enrolled on Clinical Trials Compared With Standard Care

Author

Sidana, Surbhi, primary, Allmer, Cristine, additional, Larson, Melissa C., additional, Dueck, Amylou, additional, Yost, Kathleen, additional, Warsame, Rahma, additional, Thanarajasingam, Gita, additional, Cerhan, James R., additional, Paludo, Jonas, additional, Rajkumar, S. Vincent, additional, Habermann, Thomas M., additional, Nowakowski, Grzegorz S., additional, Lin, Yi, additional, Gertz, Morie A., additional, Witzig, Thomas, additional, Dispenzieri, Angela, additional, Gonsalves, Wilson I., additional, Ansell, Stephen M., additional, Thompson, Carrie A., additional, and Kumar, Shaji K., additional

Published
2022
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213. Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: Results from two independent cohorts

Author

Ghesquières, Hervé, Maurer, Matthew J., Casasnovas, Olivier, Ansell, Stephen M., Larrabee, Beth R., Lech-Maranda, Eva, Novak, Anne J., Borrel, Anne-Laure, Slager, Susan L., Brice, Pauline, Allmer, Cristine, Brion, Annie, Ziesmer, Steven C., Morschhauser, Franck, Habermann, Thomas M., Gaillard, Isabelle, Link, Brian K., Stamatoullas, Aspasia, Fermé, Christophe, Dogan, Ahmet, Macon, William R., Audouin, Josée, Cerhan, James R., and Salles, Gilles

Published
2013
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216. The Mayo Clinic Biobank: A Building Block for Individualized Medicine

Author

Olson, Janet E., Ryu, Euijung, Johnson, Kiley J., Koenig, Barbara A., Maschke, Karen J., Morrisette, Jody A., Liebow, Mark, Takahashi, Paul Y., Fredericksen, Zachary S., Sharma, Ruchi G., Anderson, Kari S., Hathcock, Matthew A., Carnahan, Jason A., Pathak, Jyotishman, Lindor, Noralane M., Beebe, Timothy J., Thibodeau, Stephen N., and Cerhan, James R.

Published
2013
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218. The significance of gradient expression of chromosome region maintenance protein 1 in large cell lymphoma

Author

Abeykoon, Jithma P., Hampel, Paul J., King, Rebecca L., Wood, Adam J., Larson, Melissa C., Nowakowski, Kevin E., Zanwar, Saurabh S., Dasari, Surendra, Ruan, Gordon J., Ravindran, Aishwarya, Wellik, Linda E., Paludo, Jonas, Link, Brian K., Cerhan, James R., Ansell, Stephen M., Nowakowski, Grzegorz S., Thompson, Carrie A, Maurer, Matthew J., Wenzl, Kerstin, Novak, Anne J., Wu, Xiaosheng, Habermann, Thomas M., and Witzig, Thomas E.

Subjects
Chromosome Aberrations, Lymphoma, Non-Hodgkin, Humans, Lymphoma, Large B-Cell, Diffuse, Karyopherins, Letters to the Editor, Chromosomes
Published
2021

219. Household endotoxin levels and the risk of non-Hodgkin lymphoma

Author

Wang, Jun, Cozen, Wendy, Thorne, Peter S., Berhane, Kiros, Cerhan, James R., Hartge, Patricia, Ward, Mary H., De Roos, Anneclaire J., Severson, Richard K., Morton, Lindsay M., Bernstein, Leslie, Linet, Martha S., and Colt, Joanne S.

Published
2013

220. Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium

Author

Gibson, Todd M., Smedby, Karin E., Skibola, Christine F., Hein, David W., Slager, Susan L., de Sanjosé, Silvia, Vajdic, Claire M., Zhang, Yawei, Chiu, Brian C.-H., Wang, Sophia S., Hjalgrim, Henrik, Nieters, Alexandra, Bracci, Paige M., Kricker, Anne, Zheng, Tongzhang, Kolar, Carol, Cerhan, James R., Darabi, Hatef, Becker, Nikolaus, Conde, Lucia, Holford, Theodore R., Weisenburger, Dennis D., De Roos, Anneclaire J., Butterbach, Katja, Riby, Jacques, Cozen, Wendy, Benavente, Yolanda, Palmers, Casey, Holly, Elizabeth A., Sampson, Joshua N., Rothman, Nathaniel, Armstrong, Bruce K., and Morton, Lindsay M.

Published
2013

221. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, Rothman, Nathaniel, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, and Rothman, Nathaniel

Abstract

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.

Published
2022

222. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

Berndt, Sonja, I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David, V, Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Joseph F., Jr., Gabbas, Attilio, Ghesquieres, Herve, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Herve, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van den Berg, Anke, Van den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., Rothman, Nathaniel, Berndt, Sonja, I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F., Morton, Lindsay M., Brooks-Wilson, Angela R., Teras, Lauren R., Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brown, Elizabeth E., Burdett, Laurie, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Chung, Charles C., Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David, V, Cox, David G., Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W. Ryan, Dogan, Ahmet, Edlund, Christopher K., Foretova, Lenka, Fraumeni, Joseph F., Jr., Gabbas, Attilio, Ghesquieres, Herve, Giles, Graham G., Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haiman, Christopher A., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K., Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Monnereau, Alain, Montalvan, Rebecca, North, Kari E., Novak, Anne J., Onel, Kenan, Purdue, Mark P., Rand, Kristin A., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Song, Lei, Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stephens, Deborah, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Herve, Tinker, Lesley F., Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van den Berg, Anke, Van den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., and Rothman, Nathaniel

Abstract

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture., Correction in: Leukemia, vol. 37, issue 10, article ID 2142DOI: 10.1038/s41375-023-01978-x

Published
2022
Full Text
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223. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Author

IRAS OH Epidemiology Chemical Agents, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, Rothman, Nathaniel, IRAS OH Epidemiology Chemical Agents, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, and Rothman, Nathaniel

Published
2022

224. B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

Author

Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, Smedby, Karin E., Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, and Smedby, Karin E.

Abstract

Background: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. Methods: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n ¼ 1,914), follicular lymphoma (n ¼ 1,733), and marginal zone lymphoma (MZL; n ¼ 407), using unconditional logistic regression. Results: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR ¼ 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR ¼ 1.81; 95% CI, 1.59–2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR ¼ 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) ¼ 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction. Conclusions: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. Impact: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.

Published
2022

225. Cohort Profile: The Lymphoma Specialized Program of Research Excellence (SPORE) Molecular Epidemiology Resource (MER) Cohort Study

Author

Cerhan, James R, Link, Brian K, Habermann, Thomas M, Maurer, Matthew J, Feldman, Andrew L, Syrbu, Sergei I, Thompson, Carrie A, Farooq, Umar, Novak, Anne J, Slager, Susan L, Allmer, Cristine, Lunde, Julianne J, Macon, William R, Inwards, David J, Johnston, Patrick B, Micallef, Ivana NM, Nowakowski, Grzegorz S, Ansell, Stephen M, Kay, Neil E, Weiner, George J, and Witzig, Thomas E

Published
2017
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234. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

Author

Lohr, Jens G., Stojanov, Petar, Lawrence, Michael S., Auclair, Daniel, Chapuy, Bjoern, Sougnez, Carrie, Cruz-Gordillo, Peter, Knoechel, Birgit, Asmann, Yan W., Slager, Susan L., Novak, Anne J., Dogan, Ahmet, Ansell, Stephen M., Link, Brian K., Zou, Lihua, Gould, Joshua, Saksena, Gordon, Stransky, Nicolas, Rangel-Escareño, Claudia, Fernandez-Lopez, Juan Carlos, Hidalgo-Miranda, Alfredo, Melendez-Zajgla, Jorge, Hernández-Lemus, Enrique, Schwarz-Cruz y Celis, Angela, Imaz-Rosshandler, Ivan, Ojesina, Akinyemi I., Jung, Joonil, Pedamallu, Chandra S., Lander, Eric S., Habermann, Thomas M., Cerhan, James R., Shipp, Margaret A., Getz, Gad, and Golub, Todd R.

Published
2012

236. A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32

Author

Cozen, Wendy, Li, Dalin, Best, Timothy, Van Den Berg, David J., Gourraud, Pierre-Antoine, Cortessis, Victoria K., Skol, Andrew D., Mack, Thomas M., Glaser, Sally L., Weiss, Lawrence M., Nathwani, Bharat N., Bhatia, Smita, Schumacher, Fredrick R., Edlund, Christopher K., Hwang, Amie E., Slager, Susan L., Fredericksen, Zachary S., Strong, Louise C., Habermann, Thomas M., Link, Brian K., Cerhan, James R., Robison, Leslie L., Conti, David V., and Onel, Kenan

Published
2012
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237. Abstract 741: Evaluation of etiologic heterogeneity for risk of diffuse large B-cell lymphoma (DLBCL) subtype defined by cell-of-origin

Author

Kleinstern, Geffen, primary, Robinson, Dennis P., additional, Rimsza, Lisa M., additional, Larson, Melissa C., additional, King, Rebecca L., additional, Nowakowski, Grzegorz S., additional, Thompson, Carrie A., additional, Ansell, Stephen M., additional, Maurer, Matthew J., additional, Feldman, Andrew L., additional, Slager, Susan L., additional, Novak, Anne J., additional, Habermann, Thomas M., additional, and Cerhan, James R., additional

Published
2022
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238. Abstract 5256: Incidence of squamous cell carcinoma (SCC) in a large screening cohort of monoclonal B-cell lymphocytosis (MBL)

Author

Ansari, Ahmed Nadeem, primary, Achenbach, Sara J., additional, Parikh, Sameer A., additional, Kleinstern, Geffen, additional, Norman, Aaron D., additional, Rabe, Kari G., additional, Lesnick, Connie E., additional, Call, Timothy G., additional, Olson, Janet E., additional, Cerhan, James R., additional, Kay, Neil E., additional, Vachon, Celine M., additional, Braggio, Esteban, additional, Hanson, Curtis A., additional, Shanafelt, Tait D., additional, Baum, Christian L., additional, and Slager, Susan L., additional

Published
2022
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240. Long-Term Health-Related Quality of Life of Autologous Hematopoietic Cell Transplantation Patients and Nontransplant Patients With Aggressive Lymphoma: A Prospective Cohort Analysis

Author

Strouse, Christopher S., primary, Larson, Melissa C., additional, Ehlers, Shawna L., additional, Yost, Kathleen J., additional, Maurer, Matthew J., additional, Ansell, Stephen M., additional, Inwards, David J., additional, Johnston, Patrick B., additional, Micallef, Ivana N., additional, Link, Brian K., additional, Farooq, Umar, additional, Cerhan, James R., additional, and Thompson, Carrie A., additional

Published
2022
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242. PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts

Author

Desai, Sanjal H., primary, Pederson, Levi, additional, LaPlant, Betsy, additional, Mwangi, Raphael, additional, Maurer, Matthew, additional, Young, Jason R., additional, Macon, William R., additional, King, Rebecca L., additional, Wang, Yucai, additional, Cerhan, James R., additional, Feldman, Andrew, additional, Inwards, David J., additional, Micallef, Ivana, additional, Johnston, Patrick, additional, Porrata, Luis F., additional, Ansell, Stephen M., additional, Habermann, Thomas M., additional, Witzig, Thomas E., additional, and Nowakowski, Grzegorz S., additional

Published
2022
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244. Revised MALT-IPI: A new predictive model that identifies high-risk patients with extranodal marginal zone lymphoma

Author

Alderuccio, Juan Pablo, Reis, Isildinha M, Habermann, Thomas M, Link, Brian K, Thieblemont, Catherine, Conconi, Annarita, Larson, Melissa C, Cascione, Luciano, Zhao, Wei, Cerhan, James R, Zucca, Emanuele, and Lossos, Izidore S

Subjects
610 Medizin und Gesundheit
Abstract

Extranodal marginal zone lymphoma (EMZL) is a heterogeneous disease with a subset of patients exhibiting a more aggressive course. We previously reported that EMZL with multiple mucosal sites (MMS) at diagnosis is characterized by shorter survival. To better recognize patients with different patterns of progression-free survival (PFS) we developed and validated a new prognostic index primarily based on patient's disease characteristics. We derived the "Revised mucosa-associated lymphoid tissue International Prognostic Index" (Revised MALT-IPI) in a large data set (n=397) by identifying candidate variables that showed highest prognostic association with PFS. The revised MALT-IPI was validated in two independent cohorts, from the University of Iowa/Mayo Clinic (n=297) and from IELSG-19 study (n=400). A stepwise Cox regression analysis yielded a model including four independent predictors of shorter PFS. Revised MALT-IPI has scores ranging from 0 to 5, calculated as a sum of 1 point for each of the following- age >60 years, elevated LDH, and stage III-IV; and 2 points for MMS. In the training cohort, the Revised MALT-IPI defined 4 risk groups: low risk (score 0, reference group), low-medium risk (score 1, HR=1.85, P=0.008), medium-high risk (score 2, HR=3.84, P

Published
2022
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247. Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Author

Chapuy, Bjoern, Stewart, Chip, Dunford, Andrew J., Kim, Jaegil, Kamburov, Atanas, Redd, Robert A., Lawrence, Mike S., Roemer, Margaretha G. M., Li, Amy J., Ziepert, Marita, Staiger, Annette M., Wala, Jeremiah A., Ducar, Matthew D., Leshchiner, Ignaty, Rheinbay, Ester, Taylor-Weiner, Amaro, Coughlin, Caroline A., Hess, Julian M., Pedamallu, Chandra S., Livitz, Dimitri, Rosebrock, Daniel, Rosenberg, Mara, Tracy, Adam A., Horn, Heike, van Hummelen, Paul, Feldman, Andrew L., Link, Brian K., Novak, Anne J., Cerhan, James R., Habermann, Thomas M., Siebert, Reiner, Rosenwald, Andreas, Thorner, Aaron R., Meyerson, Matthew L., Golub, Todd R., Beroukhim, Rameen, Wulf, Gerald G., Ott, German, Rodig, Scott J., Monti, Stefano, Neuberg, Donna S., Loeffler, Markus, Pfreundschuh, Michael, Trümper, Lorenz, Getz, Gad, and Shipp, Margaret A.

Published
2018
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