22,903 results on '"Chen Dong"'
Search Results
202. Derivation of trophoblast stem cells from naïve human pluripotent stem cells
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Chen Dong, Mariana Beltcheva, Paul Gontarz, Bo Zhang, Pooja Popli, Laura A Fischer, Shafqat A Khan, Kyoung-mi Park, Eun-Ja Yoon, Xiaoyun Xing, Ramakrishna Kommagani, Ting Wang, Lilianna Solnica-Krezel, and Thorold W Theunissen
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naive pluripotency ,primed pluripotency ,trophectoderm ,trophoblast stem cells ,RNA-seq ,ATAC-seq ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized. As naïve hPSCs share transcriptional and epigenomic signatures with trophoblast cells, it has been proposed that the naïve state may have enhanced predisposition for differentiation along this extraembryonic lineage. Here we examined the trophoblast potential of isogenic naïve and primed hPSCs. We found that naïve hPSCs can directly give rise to human trophoblast stem cells (hTSCs) and undergo further differentiation into both extravillous and syncytiotrophoblast. In contrast, primed hPSCs do not support hTSC derivation, but give rise to non-self-renewing cytotrophoblasts in response to BMP4. Global transcriptome and chromatin accessibility analyses indicate that hTSCs derived from naïve hPSCs are similar to blastocyst-derived hTSCs and acquire features of post-implantation trophectoderm. The derivation of hTSCs from naïve hPSCs will enable elucidation of early mechanisms that govern normal human trophoblast development and associated pathologies.
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- 2020
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203. Risk of reduced platelet counts in patients with nonalcoholic fatty liver disease (NAFLD): a prospective cohort study
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Fang Liu, Hui Zhou, Lei Cao, Zhirong Guo, Chen Dong, Lugang Yu, Yiying Wang, Chunxing Liu, Jing Qiu, Yong Xue, Xingxiang Liu, and Yunfang Xu
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Nonalcoholic fatty liver disease (NAFLD) ,Platelet counts ,Cohort ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background The production of peripheral platelet is mainly regulated by thrombopoietin, which is a glycoprotein hormone predominantly synthesized in the liver. Previously, many studies have reported that there was an inverse correlation between the degree of chronic viral hepatitis and the peripheral platelet count. However, the effect of nonalcoholic fatty liver disease (NAFLD) on the peripheral platelet counts remains unclear. Methods With 1303 participants from “The prevention of MS and multi-metabolic disorders in Jiangsu province of China (PMMJS)” cohort study, we investigated the associations between NAFLD and the risk of platelet counts reduction in Chinese adults. The paired-samples T test was used to explore the platelet counts changes between baseline and follow-up. Multivariate logistic regression was used to examine the association between presence of NAFLD and the risk of platelet reduction by calculating the odds ratios (ORs) and 95% confidence interval (CI). Results After five years of follow-up, platelet counts were markedly reduced from 220.6 ± 42.22 (109/L) at baseline to 208.41 ± 40.70 (109/L) at follow-up in NAFLD group (P
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- 2018
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204. A machine-learning-based hardware-Trojan detection approach for chips in the Internet of Things
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Chen Dong, Jinghui Chen, Wenzhong Guo, and Jian Zou
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Electronic computers. Computer science ,QA75.5-76.95 - Abstract
With the development of the Internet of Things, smart devices are widely used. Hardware security is one key issue in the security of the Internet of Things. As the core component of the hardware, the integrated circuit must be taken seriously with its security. The pre-silicon detection methods do not require gold chips, are not affected by process noise, and are suitable for the safe detection of a very large-scale integration. Therefore, more and more researchers are paying attention to the pre-silicon detection method. In this study, we propose a machine-learning-based hardware-Trojan detection method at the gate level. First, we put forward new Trojan-net features. After that, we use the scoring mechanism of the eXtreme Gradient Boosting to set up a new effective feature set of 49 out of 56 features. Finally, the hardware-Trojan classifier was trained and detected based on the new feature set by the eXtreme Gradient Boosting algorithm, respectively. The experimental results show that the proposed method can obtain 89.84% average Recall , 86.75% average F-measure , and 99.83% average Accuracy , which is the best detection result among existing machine-learning-based hardware-Trojan detection methods.
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- 2019
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205. Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
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Chen Dong, Jason Fontana, Anika Patel, James M. Carothers, and Jesse G. Zalatan
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Science - Abstract
The absence of effective gene activators in bacteria limits regulated expression programs. Here the authors design synthetic bacterial CRISPR-Cas transcriptional activators that can be used to construct multi-gene programs of activation and repression.
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- 2018
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206. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3
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Kentaro Tanaka, Gustavo J. Martinez, Xiaowei Yan, Weiwen Long, Kenji Ichiyama, Xinxin Chi, Byung-Seok Kim, Joseph M. Reynolds, Yeonseok Chung, Shinya Tanaka, Lan Liao, Yoichi Nakanishi, Akihiko Yoshimura, Pan Zheng, Xiaohu Wang, Qiang Tian, Jianming Xu, Bert W. O’Malley, and Chen Dong
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Biology (General) ,QH301-705.5 - Abstract
Summary: T helper 17 (Th17) cell development is programmed by the orphan nuclear receptor RORγt, but the underlying mechanism is not well understood. Nuclear receptor-mediated transcriptional activation depends on coactivators. Here, we show that steroid receptor coactivator-3 (SRC-3) critically regulates Th17 cell differentiation. Reduced incidence of experimental autoimmune encephalitis (EAE) associated with decreased Th17 cell generation in vivo was observed in mice with SRC-3 deletion specifically in T cells. In vitro, SRC-3 deficiency did not affect TGF-β/IL-6-induced Th17 cell generation but severely impaired pathogenic Th17 differentiation induced by IL-1/IL-6/IL-23. Microarray analysis revealed that SRC-3 not only regulates IL-17A but also IL-1R1 expression. SRC-3 bound to Il17a and Il1r1 loci in a RORγt-dependent manner and was required for recruitment of the p300 acetyltransferase. Thus, SRC-3 is critical for RORγt-dependent gene expression in Th17 cell-driven autoimmune diseases. : The unique transcriptional programs in IL-1-induced inflammatory Th17 cells have remained unclear. Tanaka et al. demonstrate that SRC-3 in CD4+ T helper cells functions as a specific coactivator of RORγt, a master transcription factor of Th17 cells, by regulating IL-1-IL1R1 signaling. Keywords: steroid receptor coactivator-3, pathogenic Th17, RORγt, EAE, IL1R1, IL17A, p300
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- 2018
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207. Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
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Yu Jiang, Ying Liu, Huiping Lu, Shao-Cong Sun, Wei Jin, Xiaohu Wang, and Chen Dong
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Science - Abstract
T help 17 (Th17) cells are important mediators for both protective and pathogenic immune reactions, but how their functions are regulated at the epigenetic level is not understood. Here the authors show that TRIM28, a cofactor for transcriptional regulation, is important for epigenetic activation of Th17-related gene loci during Th17 response.
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- 2018
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208. Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population
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Maolin Gu, Jing Qiu, Daoxia Guo, Yunfang Xu, Xingxiang Liu, Chong Shen, and Chen Dong
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Hepatitis A virus ,Hepatitis E virus ,Single-nucleotide polymorphism ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Recent GWAS-associated studies reported that single nucleotide polymorphisms (SNPs) in ABCB1, TGFβ1, XRCC1 genes were associated with hepatitis A virus (HAV) infection, and variants of APOA4 and APOE genes were associated with and hepatitis E virus (HEV) infection in US population. However, the associations of these loci with HAV or HEV infection in Chinese Han population remain unclear. Methods A total of 3082 Chinese Han persons were included in this study. Anti-HAV IgG and anti-HEV IgG were detected by enzyme-linked immunosorbent assay (ELISA). Genotypes in ABCB1, TGFβ1, XRCC1, APOA4 and APOE SNPs were determined by TaqMan MGB technology. Results In Chinese Han population, rs1045642 C to T variation in ABCB1 was significantly associated with the decreased risk of HAV infection (P
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- 2018
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209. INTELLIGENT PREDICTION METHOD ON STABILITY OF THIN-WALL STEEL COMPONENT WITH NON CONTINUOUS CROSS SECTION
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SONG YiMing, LV ZhiJun, CHEN Dong, and WU YongMei
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Ultimate bearing capacity ,Non continuous section ,Back propagation ,Section properties ,Stability design ,Mechanical engineering and machinery ,TJ1-1570 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The factors,which influence the stability of thin-wall perforated steel components are complex. Take the columns as an example,in the existing research,much attention has been paid to the continuous section,but little paper on noncontinuous one. According to the characteristics of the non continuous cross section,based on performance testing and finite element analysis of columns,with the method of BP neural network intelligent stability prediction,the stability prediction model of the columns is established. The predict results are compared with the test data,and the error is less than 2%,which is more accurate than the finite element analysis results. It is very promising that the intelligent prediction method has applied in the structure engineering.
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- 2018
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210. RESEARCH ON THE DESIGN OF GUIDE PLATE FOR TANDEM HONEYCOMB STABILITY MAINTANCE
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CHEN Dong, LU ZhaiJun, and XIONG YuPu
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Tandem honeycomb ,Connection plate ,Deformation stability ,Guiding function ,Anti-destabilization ,Mechanical engineering and machinery ,TJ1-1570 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Based on the application of the honeycomb in the square guide rail,analyzed the tandem honeycomb deformation stability by experiments. Found tandem honeycomb is prone to instability in the impact process for the effect of uneven strength of simple honeycomb and impact load deflection. Analysis shows that the plate, with low intensity or its sectional dimension is smaller than guide rail section, is difficult to prevent honeycomb instability. To improve the effect of connection on keep tandem honeycomb deformation stability, studied the relationship among plate sectional dimension, guide rail sectional dimension and plate deflection degree from the theoretical level: when the guide rail sectional dimension unchanged, the longer the length of connection plate is, the smaller the deflection angle of plate is, the smaller the friction between plate and guide rail is, the better the guiding function of connection plate is. Based on the conclusion, designed a new guiding plate, it is not only improves tandem honeycomb deformation stability, but also solves the honeycomb peeling.
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- 2018
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211. Performance Analysis of Secret Precoding-Aided Spatial Modulation With Finite-Alphabet Signaling
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Feilong Wu, Wenjie Wang, Chen Dong, and Lie-Liang Yang
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Spatial modulation (SM) ,bit error rate (BER) ,secrecy capacity ,power-allocation ,artificial noise ,finite-alphabet inputs ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The precoding-aided spatial modulation (PSM) is first characterized with respect to its secrecy performance, which shows that the PSM is a secrecy embedded communication scheme when operated in the time-division duplex mode, but experiences security risk under frequency-division duplex mode. Therefore, we extend the PSM to a secret PSM (SPSM) that is suitable for operation in any communications scenarios experiencing passive eavesdropping. In the proposed SPSM, the secrecy performance is enhanced by using a part of transmit power to interfere the eavesdropper's reception. In this paper, the secrecy performance of SPSM with discrete inputs is comprehensively investigated in terms of both bit error rate and secrecy rate and by both analysis and simulations. Relying on the asymptotic analysis, we also derive the upper and lower bounds for the error performance and secrecy rate of SPSM. Furthermore, we study the power allocation between information and interference transmission in order to maximize SPSM's secrecy performance. Our studies result in a range of expressions, which are validated by Monte Carlo simulations. Furthermore, our studies demonstrate that the analytical formulas are beneficial to the optimization of SPSM systems for maximizing its security performance.
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- 2018
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212. Adaptive Function Expansion 3-D Diagonal-Structure Bilinear Filter for Active Noise Control of Saturation Nonlinearity
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Xinnian Guo, Yang Li, Jean Jiang, Chen Dong, Sidan Du, and Lizhe Tan
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Active noise control (ANC) ,bilinear filter ,function expansion bilinear filter ,3-D diagonal structure ,signal saturation ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
In this paper, a general function expansion bilinear (FEB) filter with a 3-D diagonal structure is proposed to deal with the problem of saturation nonlinearity in active noise control (ANC) systems. In an ANC system, the reference microphone and/or loudspeaker may be saturated when the acoustic noise and/or the controller output exceeds the dynamic limits of electronic devices. Such saturation nonlinearity degrades the control performance of the linear and some nonlinear control filters equipped with a filtered-x least mean square (FXLMS) algorithm. In order to tackle the problem of signal saturation, we use a new nonlinear saturation ANC (NSANC) model and derive a function expansion diagonal-structure bilinear FXLMS (FEDBFXLMS) algorithm. The performance of the proposed filters equipped with the associated FEDBFXLMS algorithm is validated through the analysis of computational complexity and simulations of various nonlinearities for NSANC systems. Computer simulation results demonstrate that the proposed FEB filter can achieve significant performance improvement in reducing saturation effects in comparison with the diagonal-channel bilinear filter and the recursive second-order Volterra filter based on the FXLMS algorithm, which often outperform the conventional nonlinear Volterra and functional link artificial neural network (FLANN) filters.
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- 2018
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213. Retraction Note: A positive feedback loop consisting of C12orf59/NF-κB/CDH11 promotes gastric cancer invasion and metastasis
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Zhang Jia-Xing, He Wei-Ling, Feng Zi-Hao, Chen Dong-Liang, Gao Ying, He Ying, Qin Kai, Zheng Zhou-San, Chen Cui, Weng Hui-Wen, Yun Miao, Ye Sheng, Xu Rui-Hua, and Xie Dan
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1114-2.
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- 2021
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214. Free Space Measurement Device Independent Quantum Key Distribution with Modulating Retro-Reflectors under Correlated Turbulent Channel
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Xingyu Wang, Wei Liu, Tianyi Wu, Chang Guo, Yijun Zhang, Shanghong Zhao, and Chen Dong
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MDI-QKD ,modulating retro-reflector ,double-pass channel ,atmosphere turbulence ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Modulating retro-reflector (MRR), originally introduced to support laser communication, relieves most of the weight, power, and pointing requirements to the ground station. In this paper, a plug-and-play measurement device independent quantum key distribution (MDI-QKD) scheme with MRR is proposed not only to eliminate detector side channels and allow an untrusted satellite relay between two users, but also to simplify the requirements set-ups in practical flexible moving scenarios. The plug-and-play architecture compensates for the polarization drift during the transmission to provide superior performance in implementing the MDI-QKD on a free-space channel, and the MRR device is adopted to relax the requirements on both communication terminals. A double-pass correlated turbulent channel model is presented to investigate the complex and unstable channel characteristics caused by the atmospheric turbulence. Furthermore, the security of the modified MDI-QKD scheme is analyzed under some classical attacks and the simulation results indicate the feasibility under the situation that the system performance deteriorates with the increase of fading correlation coefficient and the turbulence intensity, which provides a meaningful step towards an MDI-QKD based on the moving platforms to join a dynamic quantum network with untrusted relays.
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- 2021
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215. Preparation and Properties of Solar Absorbing AAO Composite Oxide Film Coatings
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WEI Hong-yang, CHANG Meng-lei, CHEN Dong-chu, WANG Mei-feng, and YE Xiu-fang
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anodic aluminum oxide ,AC deposition ,Cu-Ni nano composite particle ,absorptivity ,emissivity ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The highly ordered porous anodic alumina was prepared by anodic oxidation technology, after being treated by AC phosphoric pore broadening, the Cu-Ni nano composite particles were deposited into anodic alumina pores by AC frequency with 50Hz in different voltages, different time and different temperatures. The spectra result shows that the coating prepared under the conditions of voltage is 12V, time is 600s, temperature is 25℃ has good solar absorption performance, the absorptivity is 0.91, emissivity is 0.18, quality factor is 4.9. The SEM and XRD analysis show that CuAl2O4/Cu-Ni composite nanorods were deposited on the surface of the composite oxide coating. After heat treatment at 600℃, the solar absorption and infrared emission of target coating have a small fluctuation and the thermal stability of the coating system is greatly improved. The existing of CuAl2O4 limits the diffusion of metal particles under high temperature environment at the interface, which prevents the Cu/Ni from being oxidized.
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- 2017
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216. BANOVA: An R Package for Hierarchical Bayesian ANOVA
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Chen Dong and Michel Wedel
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hierarchical Bayes regression ,ANOVA ,BANOVA ,MCMC ,BUGS modeling ,Statistics ,HA1-4737 - Abstract
In this paper, we develop generalized hierarchical Bayesian ANOVA, to assist experimental researchers in the behavioral and social sciences in the analysis of experiments with within- and between-subjects factors. The method alleviates several limitations of classical ANOVA, still commonly employed in those fields of research. An accompanying R Package for BANOVA is developed. It offers statistical routines and several easy-to-use functions for estimation of hierarchical Bayesian ANOVA models that are tailored to the analysis of experimental research. MCMC simulation is used to simulate posterior samples of the parameters of each model specified by the user. The core program is written in R and JAGS. After preparing the data in the required format, users simply select an appropriate model, and can estimate it without any advanced coding being required. The main aim of the R package is to offer freely accessible resources for hierarchical Bayesian ANOVA analysis, which makes it easy to use for applied researchers.
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- 2017
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217. Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation
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Xiaohu Wang, Lu Ni, Dehui Chang, Huiping Lu, Yu Jiang, Byung-Seok Kim, Aibo Wang, Xindong Liu, Bo Zhong, Xuexian Yang, and Chen Dong
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CREB ,Th17 cells ,Treg cells ,Autoimmune diseases ,Medicine ,Medicine (General) ,R5-920 - Abstract
The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in vitro and in vivo, and led to resistance to autoimmune diseases. Mechanistically, CREB, activated by CD3-PKC-ϴ signaling, plays a key role in regulating Th17 cell differentiation, at least in part through directly binding to the Il17-Il17f gene locus. Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-β-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model. Thus, CREB is critical in autoimmune diseases by promoting Th17 cell and inhibiting de novo Treg cell generation.
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- 2017
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218. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity
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Byung-Seok Kim, Huiping Lu, Kenji Ichiyama, Xiang Chen, Yi-Bing Zhang, Nipun A. Mistry, Kentaro Tanaka, Young-hee Lee, Roza Nurieva, Li Zhang, Xuexian Yang, Yeonseok Chung, Wei Jin, Seon Hee Chang, and Chen Dong
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Treg ,RORγt ,Foxp3 ,autoimmunity ,IL-17 ,Tr17 ,Biology (General) ,QH301-705.5 - Abstract
Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt+ Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORγt+ Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal RORγt+ Treg cells in their transcriptomes, peripheral RORγt+ Treg cells were derived from Foxp3+ thymic Treg cells in an antigen-specific manner. Development of these RORγt+ Treg cells, coined T regulatory 17 (Tr17) cells, depended on IL-6/Stat3 signaling. Tr17 cells showed suppressive activity against antigen-specific effector T cells in vitro. In addition, Tr17 cells efficiently inhibited myelin-specific Th17-cell-mediated CNS auto-inflammation in a passive EAE model. Collectively, our study demonstrates that Tr17 cells are effector Treg cells that potentially restrict autoimmunity.
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- 2017
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219. Development of Basketball Teaching Model under Concept of Outcome -- Outcome-Based Education for Xi'an University Students in Shaanxi Province
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Chen, Dong, Siriphan, Chanchai, and Soonjan, Rumpai
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Background and Aim: In the evolving pedagogical landscape, the Outcome-Based Education (OBE) approach has garnered attention for its student-centric model and clear educational outcomes. University in Shaanxi Province recognizes the need for an integrative basketball teaching model to harmonize with this paradigm shift. This study endeavors to design a basketball teaching model for Xi'an University students, underpinning the OBE concept. Materials and Methods: Employing a combination of interviews, questionnaires, and specialized software packages, data were collected from a population comprising 45 teachers and 5,000 first-year students, with a selected sample of 370 students and 45 teachers. The research process encompassed a thorough examination of the current teaching model, followed by the utilization of the Delphi technique and focus groups to conceptualize the OBE framework for basketball teaching. Results: Analysis revealed the need for a comprehensive basketball teaching model in higher education. The proposed OBE model integrates 4 primary elements (Basketball Theory, Basketball Skills, and Physical, and Social Adaptability), further divided into 12 secondary and 34 tertiary elements. Each segment is tailored to specific outcome objectives, emphasizing cognitive understanding, skill mastery, physical fitness, and social adaptation. Conclusion: The proposed OBE basketball teaching model offers a holistic approach to basketball education, integrating both sport-specific and life-oriented skills. By aligning with China's national development goals and the principles of education, this model stands poised to revolutionize basketball education in Xi'an, setting a benchmark for other provinces.
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- 2023
220. Thermal transport measurements of the charge density wave transition in CsV$_3$Sb$_5$
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Kountz, Erik D., Murthy, Chaitanya R., Chen, Dong, Ye, Linda, Zic, Mark, Felser, Claudia, Fisher, Ian R., Kivelson, Steven A., and Kapitulnik, Aharon
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Condensed Matter - Strongly Correlated Electrons - Abstract
We study thermalization and thermal transport in single crystals of CsV$_3$Sb$_5$ through the CDW transition by directly measuring thermal diffusivity ($D$), thermal conductivity ($\kappa$), resistivity ($\rho$), and specific heat ($c$). Commensurate with previous reports, we observe a sharp, narrow anomaly in specific heat associated with a first order transition that results in a CDW state below $\sim94$ K. While a corresponding sharp anomaly in thermal diffusivity is also observed, resistivity and thermal conductivity only exhibit small steps at the transition, where the feature is sharp for resistivity and broader for thermal conductivity. Scrutinizing the thermal Einstein relation $\kappa=cD$, we find that this relation is satisfied in the entire temperature range, except in a narrow range around the transition. The Wiedemann-Franz law seems to work outside the critical region as well. Below the transition and persisting below the two-phase regime we find strong resemblance between the resistivity anomaly and the specific heat, which may point to a secondary electronic order parameter that emerges continuously below the transition., Comment: 11 pages, 6 figures
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- 2023
221. VolumeDiffusion: Flexible Text-to-3D Generation with Efficient Volumetric Encoder
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Tang, Zhicong, Gu, Shuyang, Wang, Chunyu, Zhang, Ting, Bao, Jianmin, Chen, Dong, and Guo, Baining
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Computer Science - Computer Vision and Pattern Recognition - Abstract
This paper introduces a pioneering 3D volumetric encoder designed for text-to-3D generation. To scale up the training data for the diffusion model, a lightweight network is developed to efficiently acquire feature volumes from multi-view images. The 3D volumes are then trained on a diffusion model for text-to-3D generation using a 3D U-Net. This research further addresses the challenges of inaccurate object captions and high-dimensional feature volumes. The proposed model, trained on the public Objaverse dataset, demonstrates promising outcomes in producing diverse and recognizable samples from text prompts. Notably, it empowers finer control over object part characteristics through textual cues, fostering model creativity by seamlessly combining multiple concepts within a single object. This research significantly contributes to the progress of 3D generation by introducing an efficient, flexible, and scalable representation methodology.
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- 2023
222. Multi-Agent Reinforcement Learning for Connected and Automated Vehicles Control: Recent Advancements and Future Prospects
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Hua, Min, Chen, Dong, Qi, Xinda, Jiang, Kun, Liu, Zemin Eitan, Zhou, Quan, and Xu, Hongming
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Computer Science - Robotics ,Computer Science - Multiagent Systems - Abstract
Connected and automated vehicles (CAVs) have emerged as a potential solution to the future challenges of developing safe, efficient, and eco-friendly transportation systems. However, CAV control presents significant challenges, given the complexity of interconnectivity and coordination required among the vehicles. To address this, multi-agent reinforcement learning (MARL), with its notable advancements in addressing complex problems in autonomous driving, robotics, and human-vehicle interaction, has emerged as a promising tool for enhancing the capabilities of CAVs. However, there is a notable absence of current reviews on the state-of-the-art MARL algorithms in the context of CAVs. Therefore, this paper delivers a comprehensive review of the application of MARL techniques within the field of CAV control. The paper begins by introducing MARL, followed by a detailed explanation of its unique advantages in addressing complex mobility and traffic scenarios that involve multiple agents. It then presents a comprehensive survey of MARL applications on the extent of control dimensions for CAVs, covering critical and typical scenarios such as platooning control, lane-changing, and unsignalized intersections. In addition, the paper provides a comprehensive review of the prominent simulation platforms used to create reliable environments for training in MARL. Lastly, the paper examines the current challenges associated with deploying MARL within CAV control and outlines potential solutions that can effectively overcome these issues. Through this review, the study highlights the tremendous potential of MARL to enhance the performance and collaboration of CAV control in terms of safety, travel efficiency, and economy.
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- 2023
223. Customize-It-3D: High-Quality 3D Creation from A Single Image Using Subject-Specific Knowledge Prior
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Huang, Nan, Zhang, Ting, Yuan, Yuhui, Chen, Dong, and Zhang, Shanghang
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
In this paper, we present a novel two-stage approach that fully utilizes the information provided by the reference image to establish a customized knowledge prior for image-to-3D generation. While previous approaches primarily rely on a general diffusion prior, which struggles to yield consistent results with the reference image, we propose a subject-specific and multi-modal diffusion model. This model not only aids NeRF optimization by considering the shading mode for improved geometry but also enhances texture from the coarse results to achieve superior refinement. Both aspects contribute to faithfully aligning the 3D content with the subject. Extensive experiments showcase the superiority of our method, Customize-It-3D, outperforming previous works by a substantial margin. It produces faithful 360-degree reconstructions with impressive visual quality, making it well-suited for various applications, including text-to-3D creation., Comment: Project Page: https://nnanhuang.github.io/projects/customize-it-3d/
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- 2023
224. COLE: A Hierarchical Generation Framework for Multi-Layered and Editable Graphic Design
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Jia, Peidong, Li, Chenxuan, Yuan, Yuhui, Liu, Zeyu, Shen, Yichao, Chen, Bohan, Chen, Xingru, Zheng, Yinglin, Chen, Dong, Li, Ji, Xie, Xiaodong, Zhang, Shanghang, and Guo, Baining
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Graphic design, which has been evolving since the 15th century, plays a crucial role in advertising. The creation of high-quality designs demands design-oriented planning, reasoning, and layer-wise generation. Unlike the recent CanvaGPT, which integrates GPT-4 with existing design templates to build a custom GPT, this paper introduces the COLE system - a hierarchical generation framework designed to comprehensively address these challenges. This COLE system can transform a vague intention prompt into a high-quality multi-layered graphic design, while also supporting flexible editing based on user input. Examples of such input might include directives like ``design a poster for Hisaishi's concert.'' The key insight is to dissect the complex task of text-to-design generation into a hierarchy of simpler sub-tasks, each addressed by specialized models working collaboratively. The results from these models are then consolidated to produce a cohesive final output. Our hierarchical task decomposition can streamline the complex process and significantly enhance generation reliability. Our COLE system comprises multiple fine-tuned Large Language Models (LLMs), Large Multimodal Models (LMMs), and Diffusion Models (DMs), each specifically tailored for design-aware layer-wise captioning, layout planning, reasoning, and the task of generating images and text. Furthermore, we construct the DESIGNINTENTION benchmark to demonstrate the superiority of our COLE system over existing methods in generating high-quality graphic designs from user intent. Last, we present a Canva-like multi-layered image editing tool to support flexible editing of the generated multi-layered graphic design images. We perceive our COLE system as an important step towards addressing more complex and multi-layered graphic design generation tasks in the future., Comment: Technical report. Project page: https://graphic-design-generation-github-io.vercel.app/
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- 2023
225. PersonMAE: Person Re-Identification Pre-Training with Masked AutoEncoders
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Hu, Hezhen, Dong, Xiaoyi, Bao, Jianmin, Chen, Dongdong, Yuan, Lu, Chen, Dong, and Li, Houqiang
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Pre-training is playing an increasingly important role in learning generic feature representation for Person Re-identification (ReID). We argue that a high-quality ReID representation should have three properties, namely, multi-level awareness, occlusion robustness, and cross-region invariance. To this end, we propose a simple yet effective pre-training framework, namely PersonMAE, which involves two core designs into masked autoencoders to better serve the task of Person Re-ID. 1) PersonMAE generates two regions from the given image with RegionA as the input and \textit{RegionB} as the prediction target. RegionA is corrupted with block-wise masking to mimic common occlusion in ReID and its remaining visible parts are fed into the encoder. 2) Then PersonMAE aims to predict the whole RegionB at both pixel level and semantic feature level. It encourages its pre-trained feature representations with the three properties mentioned above. These properties make PersonMAE compatible with downstream Person ReID tasks, leading to state-of-the-art performance on four downstream ReID tasks, i.e., supervised (holistic and occluded setting), and unsupervised (UDA and USL setting). Notably, on the commonly adopted supervised setting, PersonMAE with ViT-B backbone achieves 79.8% and 69.5% mAP on the MSMT17 and OccDuke datasets, surpassing the previous state-of-the-art by a large margin of +8.0 mAP, and +5.3 mAP, respectively.
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- 2023
226. SoybeanNet: Transformer-Based Convolutional Neural Network for Soybean Pod Counting from Unmanned Aerial Vehicle (UAV) Images
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Li, Jiajia, Magar, Raju Thada, Chen, Dong, Lin, Feng, Wang, Dechun, Yin, Xiang, Zhuang, Weichao, and Li, Zhaojian
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Soybeans are a critical source of food, protein and oil, and thus have received extensive research aimed at enhancing their yield, refining cultivation practices, and advancing soybean breeding techniques. Within this context, soybean pod counting plays an essential role in understanding and optimizing production. Despite recent advancements, the development of a robust pod-counting algorithm capable of performing effectively in real-field conditions remains a significant challenge This paper presents a pioneering work of accurate soybean pod counting utilizing unmanned aerial vehicle (UAV) images captured from actual soybean fields in Michigan, USA. Specifically, this paper presents SoybeanNet, a novel point-based counting network that harnesses powerful transformer backbones for simultaneous soybean pod counting and localization with high accuracy. In addition, a new dataset of UAV-acquired images for soybean pod counting was created and open-sourced, consisting of 113 drone images with more than 260k manually annotated soybean pods captured under natural lighting conditions. Through comprehensive evaluations, SoybeanNet demonstrated superior performance over five state-of-the-art approaches when tested on the collected images. Remarkably, SoybeanNet achieved a counting accuracy of $84.51\%$ when tested on the testing dataset, attesting to its efficacy in real-world scenarios. The publication also provides both the source code (\url{https://github.com/JiajiaLi04/Soybean-Pod-Counting-from-UAV-Images}) and the labeled soybean dataset (\url{https://www.kaggle.com/datasets/jiajiali/uav-based-soybean-pod-images}), offering a valuable resource for future research endeavors in soybean pod counting and related fields., Comment: 12 pages, 5 figures
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- 2023
227. Improving Vision Anomaly Detection with the Guidance of Language Modality
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Chen, Dong, Pan, Kaihang, Wang, Guoming, Zhuang, Yueting, and Tang, Siliang
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
Recent years have seen a surge of interest in anomaly detection for tackling industrial defect detection, event detection, etc. However, existing unsupervised anomaly detectors, particularly those for the vision modality, face significant challenges due to redundant information and sparse latent space. Conversely, the language modality performs well due to its relatively single data. This paper tackles the aforementioned challenges for vision modality from a multimodal point of view. Specifically, we propose Cross-modal Guidance (CMG), which consists of Cross-modal Entropy Reduction (CMER) and Cross-modal Linear Embedding (CMLE), to tackle the redundant information issue and sparse space issue, respectively. CMER masks parts of the raw image and computes the matching score with the text. Then, CMER discards irrelevant pixels to make the detector focus on critical contents. To learn a more compact latent space for the vision anomaly detector, CMLE learns a correlation structure matrix from the language modality, and then the latent space of vision modality will be learned with the guidance of the matrix. Thereafter, the vision latent space will get semantically similar images closer. Extensive experiments demonstrate the effectiveness of the proposed methods. Particularly, CMG outperforms the baseline that only uses images by 16.81%. Ablation experiments further confirm the synergy among the proposed methods, as each component depends on the other to achieve optimal performance., Comment: 9 pages, 10 figures
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- 2023
228. Influence of Source Parameters on the Polarization Properties of Beams for Practical Free-Space Quantum Key Distribution
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Tianyi Wu, Qing Pan, Chushan Lin, Lei Shi, Shanghong Zhao, Yijun Zhang, Xingyu Wang, and Chen Dong
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QKD ,polarization properties ,free space ,channel modeling ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Polarization encoding has been extensively used in quantum key distribution (QKD) implementations along free-space links. However, the calculation model to characterize channel transmittance and quantum bit error rate (QBER) for free-space QKD has not been systematically studied. As a result, it is often assumed that misalignment error is equal to a fixed value, which is not theoretically rigorous. In this paper, we investigate the depolarization and rotation of the signal beams resulting from spatially-dependent polarization effects of the use of curved optics in an off-axis configuration, where decoherence can be characterized by the Huygens–Fresnel principle and the cross-spectral density matrix (CSDM). The transmittance and misalignment error in a practical free-space QKD can thus be estimated using the method. Furthermore, the numerical simulations clearly show that the polarization effect caused by turbulence can be effectively mitigated when maintaining good beam coherence properties.
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- 2021
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229. Overlapping Community Detection Based on Attribute Augmented Graph
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Hanyang Lin, Yongzhao Zhan, Zizheng Zhao, Yuzhong Chen, and Chen Dong
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attributed networks ,augmented attribute graph ,community detection ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
There is a wealth of information in real-world social networks. In addition to the topology information, the vertices or edges of a social network often have attributes, with many of the overlapping vertices belonging to several communities simultaneously. It is challenging to fully utilize the additional attribute information to detect overlapping communities. In this paper, we first propose an overlapping community detection algorithm based on an augmented attribute graph. An improved weight adjustment strategy for attributes is embedded in the algorithm to help detect overlapping communities more accurately. Second, we enhance the algorithm to automatically determine the number of communities by a node-density-based fuzzy k-medoids process. Extensive experiments on both synthetic and real-world datasets demonstrate that the proposed algorithms can effectively detect overlapping communities with fewer parameters compared to the baseline methods.
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- 2021
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230. Newest data on fluoroquinolone resistance mechanism of Shigella flexneri isolates in Jiangsu Province of China
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Tingting Qin, Huimin Qian, Wenting Fan, Ping Ma, Lu Zhou, Chen Dong, Bing Gu, and Xiang Huo
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Shigella flexneri ,gyrA ,Plasmid ,qnrS ,Fluoroquinolone resistance ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background To determine the prevalence, antimicrobial susceptibility patterns and related presence of mutations in quinolone resistance-determining region (QRDR) genes and plasmid-mediated quinolone resistance (PMQR) among Shigella flexneri isolates obtained from Jiangsu Province, China. Methods A total of 400 Shigella flexneri clinical isolates collected during 2012–2015 were identified by biochemical and serological methods, and the antimicrobial susceptibility pattern was evaluated using the disc-diffusion method. PCR and DNA sequencing were accomplished to identify mutations in gyrA, gyrB, parC and parE, and the presence of qnrA, qnrB, qnrC, qnrD, qnrS, qepA and aac(6′)-Ib-cr genes were also detected. Results Of all the Shigella flexneri, 75.8% were resistant to nalidixic acid, and 37.0% were categorized as norfloxacin resistant. Overall, 75.5% of isolates possessed gyrA mutations (Ser83Leu, Asp87Gly/Asn and His211Tyr), while 84.3% had parC mutations (Ser80Ile, Ala81Pho, Gln91His and Ser129Pro). The most prevalent point mutations in gyrA and parC were Ser83Leu (75.5%, 302/400) and Ser80Ile (74.5%, 298/400), relatively. Besides, the Gln517Arg alternation in gyrB was detected in 13 S. flexneri isolates and no mutations were identified in parE. PMQR determinations of qnrB, qnrS and aac(6′)-Ib-cr were detected among 16 strains (4.0%). Conclusions The results presented here show that fluoroquinolone resistance in these clinical isolates result from mutations in chromosome, besides, despite the low prevalence of PMQR determinants in Jiangsu, it is essential to continue surveillance PMQR determinants in this area.
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- 2017
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231. The Microbiome Activates CD4 T-cellâmediated Immunity to Compensate for Increased Intestinal PermeabilitySummary
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Karen L. Edelblum, Gil Sharon, Gurminder Singh, Matthew A. Odenwald, Anne Sailer, Severine Cao, Sarina Ravens, Irene Thomsen, Kamal El Bissati, Rima McLeod, Chen Dong, Sandeep Gurbuxani, Immo Prinz, Sarkis K. Mazmanian, and Jerrold R. Turner
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Despite a prominent association, chronic intestinal barrier loss is insufficient to induce disease in human subjects or experimental animals. We hypothesized that compensatory mucosal immune activation might protect individuals with increased intestinal permeability from disease. We used a model in which intestinal barrier loss is triggered by intestinal epithelial-specific expression of constitutively active myosin light chain kinase (CA-MLCK). Here we asked whether constitutive tight junction barrier loss impacts susceptibility to enteric pathogens. Methods: Acute or chronic Toxoplasma gondii or Salmonella typhimurium infection was assessed in CA-MLCK transgenic or wild-type mice. Germ-free mice or those lacking specific immune cell populations were used to investigate the effect of microbial-activated immunity on pathogen translocation in the context of increased intestinal permeability. Results: Acute T gondii and S typhimurium translocation across the epithelial barrier was reduced in CA-MLCK mice. This protection was due to enhanced mucosal immune activation that required CD4+ T cells and interleukin 17A but not immunoglobulin A. The protective mucosal immune activation in CA-MLCK mice depended on segmented filamentous bacteria (SFB), because protection against early SÂ typhimurium invasion was lost in germ-free CA-MLCK mice but could be restored by conventionalization with SFB-containing, not SFB-deficient, microbiota. In contrast, chronic S typhimurium infection was more severe in CA-MLCK mice, suggesting that despite activation of protective mucosal immunity, barrier defects ultimately result in enhanced disease progression. Conclusions: Increased epithelial tight junction permeability synergizes with commensal bacteria to promote intestinal CD4+ T-cell expansion and interleukin 17A production that limits enteric pathogen invasion. Keywords: Barrier Function, Tight Junction, Microbiota, CD4 T Cell, Mucosal Immunity, Salmonella
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- 2017
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232. Identification and characterization of interferon signaling-related microRNAs in occult hepatitis B virus infection
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Yiying Wang, Peifu Zhu, Jing Qiu, Jie Wang, Huijuan Zhu, Yinwei Zhu, Lige Zhang, Jie Zhu, Xingxiang Liu, and Chen Dong
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Medicine ,Genetics ,QH426-470 - Abstract
Abstract Background Occult hepatitis B virus infection (OBI) is an important risk factor of liver cirrhosis and hepatocellular carcinoma. Type 1 interferon (IFN) signaling-related miRNAs were significantly associated with hepatitis B virus (HBV) infection. However, the characteristics of serum IFN signaling-related miRNAs in OBI remain unclear. Therefore, this study aimed to analyze the expression levels of serum IFN signaling-related miRNAs in OBI and to evaluate their potential values for OBI diagnosis. Methods Twenty serum samples for training test (10 healthy controls and 10 OBI patients) and 438 validation serum samples from healthy controls, asymptomatic HBsAg carriers (ASC), and chronic hepatitis B (CHB) and OBI patients were collected. Expression levels of 32 IFN signaling-related miRNAs were analyzed in training and validation sets of samples using RT-qPCR. Results Among 32 IFN signaling-related miRNAs, decreased miR-122 levels and increased miR-130a levels were detected in training OBI samples. Furthermore, the results from validation test showed that the mean serum miR-122 and miR-130a level was 2.28 ± 0.96 and 3.11 ± 0.93 in OBI subjects, respectively. Compared to the healthy controls, ASC and CHB patients, miR-122 levels were significantly downregulated, while miR-130a levels were significantly upregulated in OBI patients. ROC analysis indicated that miR-122 + miR-130a could differentiate OBI from healthy controls, ASC, and CHB (≥ 0.87 of AUC). Conclusions Our study suggested that decreased serum miR-122 level and increased miR-130a level were significantly associated with OBI. Moreover, a combination of miR-122 and miR-130a could be served as a potential marker for OBI diagnosis.
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- 2017
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233. Influences of obesity on the immunogenicity of Hepatitis B vaccine
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Fang Liu, Zhirong Guo, and Chen Dong
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hepatitis b vaccine ,immunogenicity ,obesity ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: Hepatitis B vaccine is regarded as the most effective method for the prevention of hepatitis B virus (HBV) infection. However, several factors such as age, body mass index and immunocompetent state have been reported to be associated with reduced immunization responses. The present commentary was aimed to discuss the influences of obesity on the immunogenicity of hepatitis B vaccines. Data sources: Available peer-reviewed literatures, practice guidelines, and statistics published on hepatitis B vaccine in obesity between 1973 and 2015. Conclusions: Obesity was significantly associated with non-response to hepatitis B vaccine immunization. The risk of nonresponsiveness of hepatitis B vaccine among obese people increased with BMI. Moreover, the obesity might lead to an increased risk of HBV vaccine-escape mutations. The mechanism responsible for decreased immunization responses in obesity included leptin-induced systemic and B cell intrinsic inflammation, impaired T cell responses and lymphocyte division and proliferation. Therefore, more studies should be performed to analyze the influences of obesity on the immunogenicity of hepatitis B vaccines to improve the immunoprotecive effect of hepatitis B vaccines in future.
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- 2017
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234. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
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Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, and Philip J. Rosenthal
- Subjects
Science - Abstract
Benzoxaboroles have been shown to be active against different pathogens. Here, the authors show that the benzoxaborole AN3661 inhibitsPlasmodium falciparum in vitroand in mouse models, and identify a homologue of a mammalian cleavage and polyadenylation specificity factor as a drug target.
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- 2017
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235. Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor
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Paramahamsa Maturu, Devin Jones, E. Cristy Ruteshouser, Qianghua Hu, Joseph M Reynolds, John Hicks, Nagireddy Putluri, Suhendan Ekmekcioglu, Elizabeth A. Grimm, Chen Dong, and Willem W Overwijk
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Wilms' tumors (WT), which accountfor 6% of all childhood cancers, arise from dysregulated differentiation of nephrogenic progenitor cells from embryonic kidneys. Though there is an improvement in the prognosis of WT, still 10% of patients with WT die due to recurrence. Thus more effective treatment approaches are necessary. We previously characterized the inflammatory microenvironment in human WT and observed the robust expression of COX-2. The aim of this study was to extend our studies to analyze the role of COX-2 pathway components in WT progression using a mouse model of WT. Herein, COX-2 pathway components such as COX-2, HIF1-α, p-ERK1/2, and p-STAT3 were upregulated in mouse and human tumor tissues. In our RPPA analysis, COX-2 was up-regulated in M15 cells after Wt1 gene was knocked down. Flow cytometry analysis showed the increased infiltration of immune suppressive inflammatory cells such as pDC's and Treg cells in tumors. The chemotactic chemokines responsible for the infiltration of these cells were also induced in CCR5 and CXCR4 dependent manner respectively. The immunosuppressive cytokines IL-10, TGF-β, and TNF-α were also up-regulated. Furthermore, more pronounced Th2 and Treg induced cytokine response was observed than Th1 response in tumors. Basing on all these evidences it is speculated that COX-2 pathway may be a beneficial target for the treatment of WT. It may be most effective as an adjuvant therapy together with other inhibitors. Thus, our current study provides a good rationale for initiating animal studies to confirm the efficacy of COX-2 inhibitors in decreasing tumor cell growth in vivo.
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- 2017
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236. IL-25 blockade inhibits metastasis in breast cancer
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Zhujun Jiang, Jingtao Chen, Xuemei Du, Hang Cheng, Xiaohu Wang, and Chen Dong
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IL-25 ,breast cancer ,metastasis ,MMTV-PyMT ,Cytology ,QH573-671 ,Animal biochemistry ,QP501-801 - Abstract
Abstract Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was expressed by tumor-infiltrating CD4+ T cells and macrophages. An IL-25 neutralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.
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- 2016
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237. Study on the role of knowledge, attitude/belief, and practice (KAP) nursing mode in treating patients with fixed orthodontic appliances
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ZHONG Yumeng, CHEN Dong, XIE Chang, and LU Zhiyun
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Knowledge attitude/belief practice ,Nursing mode ,Orthodontic ,Fixed appliance ,Malocclusion ,Medicine - Abstract
Objective To study and analyze the effect of applying the knowledge, attitude/belief, and practice (KAP) nursing mode in caring for patients who receive fixed orthodontic treatment. Methods A total of 112 patients who re⁃ ceived orthodontic treatment were selected as study subjects. They were randomly divided into an observation group and a control group, with 56 patients in each group. Patients in the control group were treated with conventional oral care, while those in the observation group were treated with the KAP nursing mode. The patients awareness of the disease, treatment compliance, and orthodontic complications were compared between the two groups. Results After treatment with the KAP nursing mode, the disease cognition score was significantly higher in the observation group than in the control group (P < 0.05). Patient compliance was better in the observation group than in the control group throughout the treatment. Pa⁃ tients in the observation group were more able to return to the hospital on time than those in the control group. The orth⁃ odontic plaque index (OPI) of patients in the observation group decreased during the treatment. The OPI of patients in the observation group was significantly lower than that of patients in the control group at 6 months (t=2.344) and 12 months (t=3.721) after the start of the treatment (P < 0.05), and the incidence of orthodontic complications in the observation group was 7.1% (4/56), significantly lower than that in the control group (26.9% (15/56); c2=9.728, P < 0.05). Conclu⁃ sion Application of the KAP nursing mode can effectively reduce the incidence of complications in patients with fixed orthodontics, improve the oral health of patients, and positively affect orthodontic treatment.
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- 2018
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238. Downregulation of a CYP74 Rubber Particle Protein Increases Natural Rubber Production in Parthenium argentatum
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Dante F. Placido, Niu Dong, Chen Dong, Von Mark V. Cruz, David A. Dierig, Rebecca E. Cahoon, Byung-guk Kang, Trinh Huynh, Maureen Whalen, Grisel Ponciano, and Colleen McMahan
- Subjects
allene oxide synthase ,guayule ,natural rubber ,RNAi ,jasmonic acid ,salicylic acid ,Plant culture ,SB1-1110 - Abstract
We report functional genomics studies of a CYP74 rubber particle protein from Parthenium argentatum, commonly called guayule. Previously identified as an allene oxide synthase (AOS), this CYP74 constitutes the most abundant protein found in guayule rubber particles. Transgenic guayule lines with AOS gene expression down-regulated by RNAi (AOSi) exhibited strong phenotypes that included agricultural traits conducive to enhancing rubber yield. AOSi lines had higher leaf and stem biomass, thicker stembark tissues, increased stem branching and improved net photosynthetic rate. Importantly, the rubber content was significantly increased in AOSi lines compared to the wild-type (WT), vector control and AOS overexpressing (AOSoe) lines, when grown in controlled environments both in tissue-culture media and in greenhouse/growth chambers. Rubber particles from AOSi plants consistently had less AOS particle-associated protein, and lower activity (for conversion of 13-HPOT to allene oxide). Yet plants with downregulated AOS showed higher rubber transferase enzyme activity. The increase in biomass in AOSi lines was associated with not only increases in the rate of photosynthesis and non-photochemical quenching (NPQ), in the cold, but also in the content of the phytohormone SA, along with a decrease in JA, GAs, and ABA. The increase in biosynthetic activity and rubber content could further result from the negative regulation of AOS expression by high levels of salicylic acid in AOSi lines and when introduced exogenously. It is apparent that AOS in guayule plays a pivotal role in rubber production and plant growth.
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- 2019
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239. Interaction influence of harmonics in MIDC transmission systems
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Wang Ling, Chen Dong, Xue Yinglin, and Wu Fangjie
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power grids ,harmonic distortion ,HVDC power transmission ,invertors ,commutation ,power system harmonics ,MIDC transmission systems ,high-voltage direct current transmission system ,multiinfeed direct current transmission systems ,inverter station ,complex interaction influence ,transmission power ,China ,electrical distance ,coupling effect ,MIIF-Pd influence factor ,MITHDu influence factor ,Shanghai power grid ,PSCAD ,EMTDC ,commutation bus ,harmonic distortion rate ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Owing to the particular distribution of energy and load, the high-voltage direct current transmission system has been greatly developed in China. A number of areas have formed the multi-infeed direct current (MIDC) transmission systems. In MIDC transmission systems, the electrical distance between the inverter stations is close and the coupling effect is strong, therefore, the interaction influence of harmonics is complex. In order to analyse this complex interaction influence, this study first introduces the influence factors multi-infeed influence factors of power (MIIF-Pd) and multi-infeed total harmonic voltage distortion (MITHDu), which are used to describe the interaction influence degree of harmonics between inverter stations. Then based on the Shanghai power grid, a simulation model of the MIDC transmission systems was built in PSCAD/EMTDC, and the interaction influence degree of harmonics in MIDC transmission systems was studied in the case of large disturbance and small disturbance exists in the inverter stations. The results show that the interaction influence of harmonics between inverter stations is related to the electrical distance, the style of disturbance, transmission power and so on. Meanwhile, the disturbance on a commutation bus mainly leads to the increase of the harmonic distortion rate in this inverter station, and has less influence on the other stations.
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- 2019
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240. Association between previous schistosome infection and incident hyperuricemia: A prospective cohort study in China.
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Guangli Wang, Yang Jing, Hui Zhou, Yi Ding, Jie Wang, Jing Qiu, Haiyong Hua, and Chen Dong
- Subjects
Medicine ,Science - Abstract
BackgroundMore than 11 million people were estimated to be infected by Schistosoma japonicum in China before the 1950s. However, seldom studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI). We aimed to investigate the association between PSI and hyperuricemia in China.MethodsFrom February 2013 to October 2013, 3,517 Chinese subjects (908 persons with PSI and 2,609 persons without PSI) were recruited from a prospective cohort study of "135". After two years, 113 and 462 participants had developed hyperuricemia in the persons with and without PSI, respectively. Multivariable logistic models were used to estimate Relative Ratios (RR) and 95% confidence intervals (CIs) for hyperuricemia.ResultsThe PSI participants had a decreased risk of hyperuricemia compared with those without PSI [adjusted RR (95%CI): 0.73 (0.55, 0.97)]. Within the PSI group, higher level of fasting plasma glucose was significantly associated with the reduced incidence of hyperuricemia in PSI population (RR: 0.40, 95% CI: 0.26-0.63). For females, hypertension, increased levels of serum creatinine and triglycerides were the risk factors for incident hyperuricemia in the PSI group.ConclusionsOur results suggest that PSI is significantly associated with the lower incidence of hyperuricemia. Moreover, elevated fasting plasma glucose might prevent the onset of hyperuricemia in PSI population.
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- 2019
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241. High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells
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Jing Li, Yi He, Jing Hao, Ling Ni, and Chen Dong
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eomes ,transcription factor ,T cell exhaustion ,cytotoxic T cells ,tumor immunity ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Eomes, a T-box transcription factor, is known important for both function and homeostasis of effector and memory T cells, but was recently also implicated in CD8+ T cell exhaustion. However, whether and how Eomes might regulate effector functions or exhaustion of CD8+ T cells, especially in the tumor setting, is unknown. Here we first show, as tumor progressed, Eomes expression was elevated in tumor-infiltrating CD8+ T cells, especially in PD-1+Tim-3+ exhausted CD8+ T cells. Complete loss of Eomes in T cells resulted in impaired development of anti-tumor CTLs, whereas deletion of one allele of Eomes in T cells decreased development of exhausted CD8+ T cells, which offered better tumor control. Integrative analysis of RNAseq and ChIPseq of Eomes-overexpressing T cells revealed that high levels of Eomes expression directly controlled expression of T cell exhaustion genes, such as Havcr2. In addition, Eomes might compete with T-bet binding to regulatory genomic loci to antagonize T-bet functions. Collectively, Eomes exerts bimodal functions in CD8+ T cells in tumor.
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- 2018
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242. B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema
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Fei Chen, Wenhui Wu, Lianhua Jin, Ariel Millman, Mark Palma, Darine W. El-Naccache, Katherine E. Lothstein, Chen Dong, Karen L. Edelblum, and William C. Gause
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Summary: Emphysema results in destruction of alveolar walls and enlargement of lung airspaces and has been shown to develop during helminth infections through IL-4R-independent mechanisms. We examined whether interleukin 17A (IL-17A) may instead modulate development of emphysematous pathology in mice infected with the helminth parasite Nippostrongylus brasiliensis. We found that transient elevations in IL-17A shortly after helminth infection triggered subsequent emphysema that destroyed alveolar structures. Furthermore, lung B cells, activated through IL-4R signaling, inhibited early onset of emphysematous pathology. IL-10 and other regulatory cytokines typically associated with B regulatory cell function did not play a major role in this response. Instead, at early stages of the response, B cells produced high levels of the tissue-protective protein, Resistin-like molecule α (RELMα), which then downregulated IL-17A expression. These studies show that transient elevations in IL-17A trigger emphysema and reveal a helminth-induced immune regulatory mechanism that controls IL-17A and the severity of emphysema. : Emphysema causes pathology that can compromise lung function, and mechanisms for reducing disease severity remain unclear. Using a helminth model, Chen et al. show that type 2 immune response triggers lung B cells to produce RELMα, which then downregulates IL-17 production in the lung to limit emphysema. Keywords: emphysema, IL-17, B lymphocytes, RELMα, helminth
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- 2018
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243. IL-17C Mitigates Murine Acute Graft-vs.-Host Disease by Promoting Intestinal Barrier Functions and Treg Differentiation
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Huanle Gong, Shoubao Ma, Shuangzhu Liu, Yonghao Liu, Ziqi Jin, Ying Zhu, Yuan Song, Lei Lei, Bo Hu, Yu Mei, Hong Liu, Yuejun Liu, Yan Wu, Chen Dong, Yang Xu, Depei Wu, and Haiyan Liu
- Subjects
IL-17C ,Acute graft-vs.-host disease ,Treg cells ,intestinal barrier functions ,inflammation ,transplantation ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Acute graft-vs.-host disease (aGVHD) is one of the major complications and results in high mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). IL-17C is involved in many inflammatory immune disorders. However, the role of IL-17C in aGVHD remains unknown. Here we demonstrated that IL-17C deficiency in the graft significantly promoted alloreactive T cell responses and induced aggravated aGVHD compared with wildtype donors in a fully MHC-mismatched allo-HSCT model. In contrast, IL-17C overexpression ameliorated aGVHD. IL-17C deficiency increased intestinal epithelial permeability and elevated inflammatory cytokine production, leading to an enhanced aGVHD progression. Tregs was reduced in recipients of IL-17C−/− graft, whilst restored after IL-17C overexpression. Decreased Treg differentiation was abrogated after neutralizing IFN-γ, but not IL-6. Moreover, depletion of Tregs diminished the protective effect of IL-17C. Of note, patients with low IL-17C expression displayed higher aGVHD incidence together with poor overall survival, thereby IL-17C could be an independent risk factor for aGVHD development. Our results are the first demonstrating the protective role of IL-17C in aGVHD by promoting intestinal barrier functions and Treg differentiation in a MHC fully mismatched murine aGVHD model. IL-17C may serve as a novel biomarker and potential therapeutic target for aGVHD.
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- 2018
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244. Feasibility of space-based measurement-device-independent quantum key distribution
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Xingyu Wang, Chen Dong, Shanghong Zhao, Yong Liu, Xiaowen Liu, and Haonan Zhu
- Subjects
measurement-device-independent ,quantum key distribution ,satellite technology ,feasibility study ,Science ,Physics ,QC1-999 - Abstract
The measurement-device-independent (MDI) quantum key distribution (QKD) is considered to be an alternative to overcome the currently trusted satellite paradigm. However, the feasibility of the space-based MDI-QKD remains unclear in terms of the factors: the high-loss uplink between a ground station and a satellite, the limited duration when two ground stations are simultaneously visible, as well as the rigorous requirements for the two-photon interference when performing the Bell-state measurement. In this paper, we present a feasibility assessment of space-based MDI-QKD based on the Micius satellite. Integrated with the orbital dynamics model and atmosphere channel model, a framework is presented to explore the whole parameters space including orbit height, elevation angle, apertures of transceiver and atmospheric turbulence intensity to give the considerations for improving key rates and subsequently provide a relevant parameter tradeoff for the implementation of space-based MDI-QKD. We further investigate the heart of MDI-QKD, the two-photon interference considerations such as the frequency calibration and time synchronization technology against Doppler shift, and the way of performing the intensity optimization method in the dynamic and asymmetric channels. Our work can be used as a pathfinder to support decisions involving as the selection of the future quantum communication satellite missions.
- Published
- 2021
- Full Text
- View/download PDF
245. Increase the rate of plasma-assisted synthesis of silver nanoparticles through additives
- Author
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Zhai Limin, Lu Ye, Chen Dong, Chen Xinyi, Liu Linsheng, and Li Chuanqi
- Subjects
Environmental sciences ,GE1-350 - Abstract
The plasma-assisted method was used to synthesize silver nanoparticles, and the growth process of silver nanoparticles (Ag-NPs) was monitored in real time by localized surface plasmon resonance (LSPR) absorption spectroscopy. The effect of additives on the synthesis of Ag-NPs was verified. It is found that the addition of isopropanol and glucose can increase the plasmon resonance absorption intensity of the reaction solution, and promote the synthesis of Ag-NPs. In the plasma-assisted method, the additives can effectively improve the synthesis efficiency of Ag-NPs, which has great inspiration for the synthesis of other metal nanoparticles.
- Published
- 2021
- Full Text
- View/download PDF
246. The First Report of Tritrichomonas Foetus and Tetratrichomonas Buttreyi in Raccoon Dogs (Nyctereutes Procyonoides) in China
- Author
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Chen, Dong-qian, Wang, Qiu-yue, Li, Qiao-qiao, Luo, Xin-yu, Wu, Xing-hua, Wang, Ji-pu, Gao, Si-chao, Liu, Xin-chao, and Li, WenChao
- Published
- 2024
- Full Text
- View/download PDF
247. Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
- Author
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Shi, Jiaqi, Wu, Wei, Chen, Dong, Liao, Ziyan, Sheng, Tao, Wang, Yanfang, Yao, Yuejun, Wu, Qing, Liu, Feng, Zhou, Ruyi, Zhu, Chaojie, Shen, Xinyuan, Mao, Zhengwei, Ding, Yuan, Wang, Weilin, Dotti, Gianpietro, Sun, Jie, Liang, Xiao, Fang, Weijia, Zhao, Peng, Li, Hongjun, and Gu, Zhen
- Published
- 2024
- Full Text
- View/download PDF
248. Impact crater recognition methods: A review
- Author
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Chen, Dong, Hu, Fan, Zhang, Liqiang, Wu, Yunzhao, Du, Jianli, and Peethambaran, Jiju
- Published
- 2024
- Full Text
- View/download PDF
249. In Situ Fenestration and Carotid-Subclavian Bypass for Left Subclavian Artery Revascularization During Thoracic Endovascular Aortic Repair
- Author
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Fan, Bowen, Fang, Kun, Tian, Chuan, Fang, Jie, Chen, Dong, Zhao, Jiawei, Luo, Mingyao, and Shu, Chang
- Published
- 2024
- Full Text
- View/download PDF
250. Strategies Towards Submicron Size and High-Performance Magnetic PGMA@Fe3O4@SiO2–COOH Microspheres with Biological Application
- Author
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Xia, Tianhao, Wang, Yunpeng, Awasthi, Pragati, Dong, Wenkun, Li, Mengting, Qiao, Xvsheng, Chen, Dong, Ling, Shisheng, and Fan, Xianping
- Published
- 2024
- Full Text
- View/download PDF
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