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1,574 results on '"Cheng, Jianjun"'

202. Long Residence Time at the Vasopressin V2 Receptor Translates into Superior Inhibitory Effects in Ex Vivo and In Vivo Models of Autosomal Dominant Polycystic Kidney Disease

Author

Zhang, Haoran, primary, Yan, Wenzhong, additional, Sun, Yongzhan, additional, Yuan, Haoxing, additional, Su, Limin, additional, Cao, Xudong, additional, Wang, Peng, additional, Xu, Zhou, additional, Hu, Youhui, additional, Wang, Zhongjian, additional, Wang, Yinan, additional, Fu, Kequan, additional, Sun, Ying, additional, Chen, Yupeng, additional, Cheng, Jianjun, additional, and Guo, Dong, additional

Published
2022
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211. Alternatively activated macrophages; a double-edged sword in allergic asthma

Author

Huaxi Xu, Sayed F. Abdelwahab, Zhaoliang Su, Kesavan Dinesh Kumar, Mohamed Abdelaziz, Aparna Vasudevan, Cheng Jianjun, Wei Cai, Ahmed Sadek, Jie Wan, Shengjun Wang, and Wang Huixuan

Subjects
0301 basic medicine, Adult, Chemokine, Allergy, medicine.medical_treatment, lcsh:Medicine, Review, Human/mice, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Humans, Child, Lung, Interleukin 4, Innate immune system, biology, business.industry, Macrophages, lcsh:R, IL-4, General Medicine, medicine.disease, Acquired immune system, Immunity, Innate, Asthma, 030104 developmental biology, Cytokine, 030220 oncology & carcinogenesis, Immunology, biology.protein, Cytokines, Chemokines, business
Abstract

BackgroundMacrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cells in the lung during allergic asthma, which is the most common chronic respiratory disease of both adults and children. Macrophages activated by Th1 cells are known as M1 macrophages while those activated by IL-4 and IL-13 are called alternatively activated macrophages (AAM) or M2 cells. AAM are subdivided into four distinct subtypes (M2a, M2b, M2c and M2d), depending on the nature of inducing agent and the expressed markers.BodyIL-4 is the major effector cytokine in both alternative activation of macrophages and pathogenesis of asthma. Thus, the role of M2a macrophages in asthma is a major concern. However, this is controversial. Therefore, further studies are required to improve our knowledge about the role of IL-4-induced macrophages in allergic asthma, through precisive elucidation of the roles of specific M2a proteins in the pathogenesis of asthma. In the current review, we try to illustrate the different functions of M2a macrophages (protective and pathogenic roles) in the pathogenesis of asthma, including explanation of how different M2a proteins and markers act during the pathogenesis of allergic asthma. These include surface markers, enzymes, secreted proteins, chemokines, cytokines, signal transduction proteins and transcription factors.ConclusionsAAM is considered a double-edged sword in allergic asthma. Finally, we recommend further studies that focus on increased selective expression or suppression of protective and pathogenic M2a markers.

Published
2020

215. Adenosine A2AReceptor (A2AAR) Ligand Screening Using the 19F-NMR Probe FPPA

Author

Zhang, Jinfeng, Feng, Dandan, Cheng, Jianjun, and Wüthrich, Kurt

Abstract

The binding affinity of G protein-coupled receptor (GPCR) ligands is customarily measured by radio-ligand competition experiments. As an alternative approach, 19F nuclear magnetic resonance spectroscopy (19F-NMR) is used for the screening of small-molecule lead compounds in drug discovery; the two methods are complementary in that the measurements are performed with widely different experimental conditions. Here, we used the structure of the A2Aadenosine receptor (A2AAR) complex with V-2006(3-(4-amino-3-methylbenzyl)-7-(furan-2-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine) as the basis for the design of a fluorine-containing probe molecule, FPPA(4-(furan-2-yl)-7-(4-(trifluoromethyl)benzyl)-7H-pyrrolo[2,3-d]pyramidin-2-amine), for binding studies with A2AAR. A protocol of experimental conditions for drug screening and measurements of drug binding affinities using 1D 19F-NMR observation of FPPAis validated with studies of known A2AAR ligands. 19F-NMR with FPPAis thus found to be a robust approach for the discovery of ligands with new core structures, which will expand the libraries of A2AAR-targeting drug candidates.

Published
2023
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216. Transformation of a Dopamine D2Receptor Agonist to Partial Agonists as Novel Antipsychotic Agents

Author

Liu, Ruiquan, Qi, Jianzhong, Wang, Huan, Fan, Luyu, Zhang, Pei, Yu, Jing, Tan, Liang, Wang, Sheng, and Cheng, Jianjun

Abstract

Designed ligands of G protein-coupled receptors can exert a spectrum of modulating effects, varying from full agonists and partial agonists to antagonists and inverse agonists. For the dopamine D2receptor (D2R), partial agonist activity is the pharmacological feature of the third-generation antipsychotics, including aripiprazole, brexpiprazole, and cariprazine. Started from a benzofuran-derived D2R full agonist O4LE6(4), which was identified using a structure-based method by us in previous studies, a series of D2R partial agonists were designed and synthesized by introducing different tail groups. Among them, compound 10bshowed excellent activity in D2R pharmacological assays. Further optimizations using a structural rigidification approach led to the discovery of brain-penetrant compounds 29cand 29d, which exhibited potent antipsychotic effects in the mouse hyperlocomotion model. Compound 29calso showed excellent drug-like pharmacokinetic properties in rats and qualifies as an antipsychotic agent that is worth further evaluations.

Published
2023
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217. Structure-based discovery of nonhallucinogenic psychedelic analogs

Author

Cao, Dongmei, primary, Yu, Jing, additional, Wang, Huan, additional, Luo, Zhipu, additional, Liu, Xinyu, additional, He, Licong, additional, Qi, Jianzhong, additional, Fan, Luyu, additional, Tang, Lingjie, additional, Chen, Zhangcheng, additional, Li, Jinsong, additional, Cheng, Jianjun, additional, and Wang, Sheng, additional

Published
2022
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232. Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents

Author

Yan, Wenzhong, primary, Ling, Lijun, additional, Wu, Yiran, additional, Yang, Kexin, additional, Liu, Ruiquan, additional, Zhang, Jinfeng, additional, Zhao, Simeng, additional, Zhong, Guisheng, additional, Zhao, Suwen, additional, Jiang, Hualiang, additional, Xie, Chengying, additional, and Cheng, Jianjun, additional

Published
2021
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237. Recent advances in alleviating food allergenicity through fermentation.

Author

Pi, Xiaowen, Yang, Yili, Sun, Yuxue, Cui, Qiang, Wan, Yin, Fu, Guiming, Chen, Hongbing, and Cheng, Jianjun

Abstract

The increasing prevalence of food allergies is a significant challenge to global food health and safety. Various strategies have been deployed to decrease the allergenicity of food for preventing and reducing related disorders. Compared to other methods, fermentation has unique advantages in reducing the allergenicity of food and may represent a new trend in preventing food-induced allergies. This review introduces the characteristics of allergens in various foods, including shellfish, soy, peanut, milk, tree nut, egg, wheat, and fish. The mechanism and pathological symptoms of allergic reactions are then summarized. Furthermore, the advantages of fermentation for reducing the allergenicity of these foods and preventing allergies are evaluated. Fermentation is an efficient approach for reducing or eliminating food allergenicity. Simultaneously, it improved the nutritional value and physicochemical properties of food materials. It is conceivable that a combination of mixed strain fermentation with additional processing, such as heat treatment, pulsed light, and ultrasonication, will efficiently reduce the allergenicity of various foods and preserve their unique taste and nutritional components, providing significance for patients with allergies. [ABSTRACT FROM AUTHOR]

Published
2022
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238. Food irradiation: a promising technology to produce hypoallergenic food with high quality.

Author

Pi, Xiaowen, Yang, Yili, Sun, Yuxue, Wang, Xibo, Wan, Yin, Fu, Guiming, Li, Xin, and Cheng, Jianjun

Subjects
FOOD irradiation, FOOD quality, NUTS, SHELLFISH, FOOD allergy, FOOD science, NUTRITIONAL value
Abstract

The increasing incidence of food allergy cases is a public health problem of global concern. Producing hypoallergenic foods with high quality, low cost, and eco-friendly is a new trend for the food industry in the coming decades. Food irradiation, a non-thermal food processing technology, is a powerful tool to reduce the allergenicity with the above advantages. This review presents a summary of recent studies about food irradiation to reduce the allergenicity of food, including shellfish, soy, peanut, milk, tree nut, egg, wheat and fish. Principles of food irradiation, including mechanisms of allergenicity-reduction, irradiation types and characteristics, are discussed. Specific effects of food irradiation are also evaluated, involving microbial decontamination, improvement or preservation of nutritional value, harmful substances reduction of food products. Furthermore, the advantages, disadvantages and limitations of food irradiation are analyzed. It is concluded that food irradiation is a safety tool to reduce the allergenicity of food effectively, with high nutritional value and long shelf-life, making it a competitive alternative technology to traditional techniques such as heating treatments. Of note, a combination of irradiation with additional processing may be a trend for food irradiation. [ABSTRACT FROM AUTHOR]

Published
2022
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243. A universal TLR7-nanoparticle adjuvant promotes broad immune responses against heterologous strains of Influenza and SARS-CoV-2

Author

Yin, Qian, primary, Luo, Wei, additional, Mallajosyula, Venkata Vamsee Aditya, additional, Bo, Yang, additional, Guo, Jing, additional, Xie, Jinghang, additional, Sun, Meng, additional, Verma, Rohit, additional, Constantz, Christian, additional, Wagar, Lisa, additional, Li, Jing, additional, Sola, Elsa, additional, Gupta, Neha, additional, Kask, Oliver, additional, Rao, Jianghong, additional, Chien, Yueh-hsiu, additional, Cheng, Jianjun, additional, Pulendran, Bali, additional, and Davis, Mark, additional

Published
2021
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248. Finding of IFNγ gene enhancers and their core sequences

Author

Lv, Zhanjun, Cheng, Jianjun, Xie, Ying, Jing, Xiangyang, Zhang, Yuan, and Wang, and Xiufang

Subjects
Nucleotide sequencing -- Research, Interferon gamma -- Genetic aspects -- Properties, DNA sequencing -- Research, Genetic engineering -- Research, Biological sciences
Abstract

DNA segmentation methods were used to study which fragments of the human IFNγ gene possess enhancer activity. The human IFNγ gene was divided into 240-bp fragments, which were inserted between the GFP gene and the Alu tandem sequence to determine whether the inserted sequences eliminate the inhibition induced by the Alu tandem sequence. We found that five different 240-bp fragments (FUIFN3F3R, IFN4F4R, IFN6F6R, IFN21F21R, and IFN22F22R) and two 60-bp core sequences (IFN6-2F2R and IFN21-3-4F3-4R) derived from the IFNγ gene contain enhancers that can activate the GFP reporter gene. These enhancers may be targets of IFNγ gene expression regulation. Key words: human IFNγ gene, enhancer, core sequence. Les auteurs ont employe une approche de segmentation de l'ADN pour identifier les fragments du gene IFNγ humain qui possedent une activite d'amplificateur. Le gene IFNγ humain a ete divise en fragments de 240 pb, lesquels ont ete inseres entre le gene de la GFP et une sequence Alu en tandem pour determiner si la sequence inseree pouvait eliminer l'inhibition induite par la sequence Alu en tandem. Les auteurs ont trouve que cinq des fragments de 240 pb (FUIFN3F3R, IFN4F4R, IFN6F6R, IFN21F21R et IFN22F22R) ainsi que deux sequences centrales de 60 pb (IFN6-2F2R et IFN21-3-4F3-4R) derives du gene IFNγ contenaient des amplificateurs pouvant activer le gene rapporteur GFP. Ces amplificateurs sont possiblement des cibles de la regulation de l'expression du gene IFNγ. [Traduit par la Redaction] Mots-cles: gene IFNγ humain, amplificateur, sequence centrale., Introduction Interferon-gamma (IFNγ), or type II interferon, is a cytokine that is critical for tumor control and for innate and adaptive immunity against viral and intracellular bacterial infections (Schoenborn and [...]

Published
2013
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