Search

Your search keyword '"Choi, Jinhee"' showing total 739 results
Start Over Author "Choi, Jinhee"
739 results on '"Choi, Jinhee"'

210. A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in Caenorhabditis elegans exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO).

Author

Chatterjee, Nivedita, Kim, Youngho, Yang, Jisu, Roca, Carlos P., Joo, Sang-Woo, and Choi, Jinhee

Subjects
GRAPHENE, CAENORHABDITIS, MITOGEN-activated protein kinases, GENE expression, POLYCYCLIC aromatic hydrocarbons
Abstract

The potential hazards of graphene nanomaterials were investigated by exposing the nematodeCaenorhabditis elegansto graphene oxide (GO) and reduced graphene oxide (rGO). The underlying mechanisms of the nano–bio interaction were addressed with an integrated systems toxicology approach using global transcriptomics, network-based pathway analysis, and experimental validation of thein-silico-derived hypotheses. Graphene oxide was found to reduce the worms’ reproductive health to a greater degree than rGO, but it did not affect survival (24 h endpoint). Comparative analysis of GO vs. rGO effects found that the wingless-type MMTV integration site family (Wnt) pathway and the mitogen-activated protein kinase (MAPK) pathway were evoked in GO- but not in rGO-exposed worms. We therefore hypothesized that crosstalk between the Wnt and MAPK pathways is responsible forC. elegans’ reproductive sensitivity to GO exposure. By targeting the individual components of the Wnt-MAPK crosstalk pathway (with qPCR gene expression and mutant reproduction analysis), we found a signaling cascade of MOM-2 → MOM-5 → MOM-4 → LIT-1 → POP-1 → EGL-5. Specifically, the activation of POP-1 (the TCF protein homolog) and subsequent repression of the Wnt/β-catenin target gene (EGL-5), analyzed with target-gene-specific RNAi in POP-1 mutant [pop-1(q645)] worms, were the central mechanisms of reduced reproductive potential in the worms exposed to GO. Our results highlight the distinct biological and molecular mechanisms of GO and rGO exposure and the role of Wnt-MAPK pathway crosstalk in regulating GO-induced reproductive failure inin vivosystems, and they will contribute to the development of efficient and innocuous graphene applications as well to improvements in mechanism-based risk assessment. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

223. Universal Design for Learning: Guidelines for Accessible Online Instruction

Author

Rogers-Shaw, Carol, Carr-Chellman, Davin J., and Choi, Jinhee

Abstract

Universal Design for Learning (UDL) is a framework for the teaching–learning transaction that conceptualizes knowledge through learner-centered foci emphasizing accessibility, collaboration, and community. Given the importance of access to achieving social justice, UDL is a promising approach to meeting all learners’ needs more effectively. In this article, the history and philosophy of UDL are discussed and elaborated, followed by an explanation of how the principles of UDL were used to improve an existing online course offering for adult learners.

Published
2018
Full Text
View/download PDF

226. New Korean Cinema

Author

Choi, Jinhee

Subjects
New Korean Cinema (Book) -- Book reviews, Books -- Book reviews, Motion pictures
Published
2007

Catalog

Books, media, physical & digital resources
See catalog results