201. Duration of storage influences the hemoglobin rising effect of red blood cells in patients undergoing major abdominal surgery
- Author
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Oliver Meyer, Willehad Boemke, Alexander Krannich, Claudia Spies, Aarne Feldheiser, Oliver Hunsicker, Jalid Sehouli, Katarina Hessler, Axel Pruß, and Ioana Braicu
- Subjects
medicine.medical_specialty ,business.industry ,Immunology ,Hematology ,030204 cardiovascular system & hematology ,Gastroenterology ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,Internal medicine ,Clinical endpoint ,Immunology and Allergy ,Medicine ,Population study ,Arterial blood ,In patient ,Hemoglobin ,business ,Clearance ,Abdominal surgery - Abstract
BACKGROUND: After transfusion of senescent red blood cells (RBCs) a considerable fraction is rapidly cleared from the recipients' circulation. Thus, transfusion of senescent RBCs may be less effective in terms of increasing hemoglobin concentration (cHb) after transfusion. STUDY DESIGN AND METHODS: Data were retrospectively obtained in patients who underwent major abdominal surgery between 2006 and 2012. Patients were eligible if they received RBCs during surgery and had at least two arterial blood gas analyses performed. The primary endpoint was the increase of recipients' cHb related to the transfusion of 1 unit of RBCs with respect to different storage periods. Four storage periods were defined according to the distribution of RBC storage of the study population. General estimating equation was used for calculation of the primary endpoint and to adjust for confounding variables. RESULTS: A total of 598 arterial blood gas samples from 120 patients, receiving 429 RBC units, were analyzed. Mean (±SD) RBC storage was 21 (±9) days. RBC storage duration and the increase in recipients' cHb were inversely and gradually related; that is, the older the RBCs, the lower the increase in the recipients' cHb after transfusion (storage
- Published
- 2018