223 results on '"Denti L"'
Search Results
202. IGF system in acute ischemic stroke.
- Author
-
Denti L, Banchini A, Caporotundo S, Giordano A, Rocci A, Merli MF, Annoni V, Salimbeni I, Mazzoni S, Ablondi F, Valenti G, and Ceda GP
- Subjects
- Aged, Aged, 80 and over, Humans, Osmolar Concentration, Stroke mortality, Brain Ischemia complications, Insulin-Like Growth Factor Binding Protein 3 metabolism, Insulin-Like Growth Factor I metabolism, Stroke etiology, Stroke metabolism
- Published
- 2002
203. Aging-related decline of gonadal function in healthy men: correlation with body composition and lipoproteins.
- Author
-
Denti L, Pasolini G, Sanfelici L, Benedetti R, Cecchetti A, Ceda GP, Ablondi F, and Valenti G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Body Constitution, Cross-Sectional Studies, Electric Impedance, Humans, Male, Middle Aged, Nutritional Status, Regression Analysis, Sex Hormone-Binding Globulin metabolism, Skinfold Thickness, Aging physiology, Body Composition physiology, Cholesterol blood, Cholesterol, HDL blood, Estradiol blood, Lipoprotein(a) blood, Testis physiology, Testosterone blood, Triglycerides blood
- Abstract
Objective: To assess if androgen decline in physiological aging contributes to the concomitant changes in body composition and lipoprotein levels., Design: Cross-sectional, observational study., Setting: A university-based outpatient center., Subjects: The study comprised 206 healthy volunteers (aged 18-95 years)., Measurements: Blood samples were drawn after an overnight fast for the assay of hormones (free testosterone (FT), estradiol (E2), and sex hormone-binding globulin (SHBG)) and lipids (total cholesterol, triglycerides, high-density lipoprotein cholesterol, and lipoprotein Lp(a)). At the same time, body composition was assessed by both anthropometry (fat mass percentage (FM%) estimated from four measures of skinfold thickness using the Durnin and Womersley equation and the Siri equation) and by bioimpedance analysis (FM% estimated using the Segal or Deurenberg equations, respectively, for subjects younger or older than 62 years)., Results: A significant age-related decline was found for FT and E2 concentrations, whereas SHBG levels were related positively with age. No significant association was apparent between hormonal changes and the concomitant modifications of body composition and lipoproteins. Only SHBG showed a significant inverse association between FM% and the waist-to-hip ratio, independent of age. The comparison between older hypogonadal (with FT levels below the lower limit of the normality range assessed in younger subjects) and eugonadal men did not show any significant differences in body composition or lipid profile., Conclusions: This study suggests that, in men, androgen decline caused by normal aging does not significantly affect some targets of testosterone action, such as body composition and lipid metabolism. Therefore, androgen supplementation in hypogonadal older men cannot be expected to influence nutritional status and body composition to the same extent that it does other main targets of testosterone action, such as sexual activity and muscle strength. However, we cannot exclude that selected subsets of older patients with low testosterone levels, especially if affected by catabolic disease, could benefit from the effects of androgen administration on nutritional status.
- Published
- 2000
- Full Text
- View/download PDF
204. Effects of 5 alpha-reductase inhibition by finasteride on lipoproteins and body composition in males affected by benign prostatic hyperplasia (BPH).
- Author
-
Denti L, Pasolini G, Cortellini P, Sanfelici L, Benedetti R, Cecchetti A, Ferretti S, Banchini A, Ablondi F, and Valenti G
- Subjects
- Aged, Cholestenone 5 alpha-Reductase, Dihydrotestosterone blood, Humans, Male, Middle Aged, Prostatic Hyperplasia blood, Body Composition drug effects, Enzyme Inhibitors therapeutic use, Finasteride therapeutic use, Lipoproteins blood, Oxidoreductases antagonists & inhibitors, Prostatic Hyperplasia drug therapy, Prostatic Hyperplasia enzymology, Prostatic Hyperplasia pathology
- Published
- 1999
205. Acute oral administration of dehydroepiandrosterone in male subjects: effect of age on bioavailability, sulfoconjugation and bioconversion in other steroids.
- Author
-
Valenti G, Banchini A, Denti L, Maggio M, Ceresini G, and Ceda GP
- Subjects
- Administration, Oral, Adult, Aged, Aged, 80 and over, Biological Availability, Dehydroepiandrosterone pharmacokinetics, Dehydroepiandrosterone Sulfate metabolism, Dehydroepiandrosterone Sulfate pharmacokinetics, Estradiol blood, Humans, Male, Steroids metabolism, Testosterone metabolism, Time Factors, Aging metabolism, Dehydroepiandrosterone administration & dosage, Dehydroepiandrosterone metabolism
- Published
- 1999
206. The contribution of androgen decline to the aging-related changes of body composition and lipoprotein in the healthy man.
- Author
-
Denti L, Pasolini G, Sanfelici L, Benedetti R, Cecchetti A, Bruschieri L, Ablondi F, and Valenti G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Aging blood, Body Constitution, Electric Impedance, Humans, Male, Middle Aged, Reference Values, Skinfold Thickness, Aging physiology, Androgens blood, Body Composition physiology, Lipoproteins blood
- Published
- 1999
207. Effects of aging on dehydroepiandrosterone sulfate in relation to fasting insulin levels and body composition assessed by bioimpedance analysis.
- Author
-
Denti L, Pasolini G, Sanfelici L, Ablondi F, Freddi M, Benedetti R, and Valenti G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Anthropometry, Electric Impedance, Female, Humans, Male, Middle Aged, Sex Characteristics, Skinfold Thickness, Aging blood, Aging physiology, Body Composition, Dehydroepiandrosterone Sulfate blood, Fasting, Insulin blood
- Abstract
Insulin can inhibit dehydroepiandrosterone (DHEA) biosynthesis in humans, as suggested by several studies performed in induced or spontaneous hyperinsulinemia. The increased insulin resistance documented throughout aging, with its accompanying hyperinsulinemia, may contribute to the age-related decline in DHEA synthesis. The aim of this study was to assess if the aging-related differences in DHEA sulfate (DHEA-S) serum levels can be associated with differences in fasting insulin levels, as well as body composition. Two hundred fifty-two healthy subjects of both sexes aged 19 to 90 years with a body mass index (BMI) less than 30 (mean +/- SD, 23.5 +/- 2.4) were studied DHEA-S and insulin serum levels were determined by a radioimmunologic procedure; body composition was assessed by anthropometry (fat mass percentage [FM%] estimated from four skinfold thicknesses by Durnin and Womersley and Siri equations [FM%-SKF]) and by bioimpedance analysis (BIA) (FM% estimated by equations developed by Segal et al and Deurenberg et al for subjects < and > 62 years, respectively [FM%-BIA]). DHEA-S levels were significantly and inversely related to age in both sexes. No significant aging-related differences were found in fasting insulin levels, although a trend toward an increase was apparent in the women on simple regression analysis. No significant associations were found between DHEA-S and insulin levels. As for body composition, a positive relationship to age was apparent for FM%-SKF, FM%-BIA, and waist to hip ratio (WHR), whereas BMI and phase angle ([PA] a bioelectric parameter considered an index of the ratio between intracellular and extracellular water) were inversely related to age. Fasting insulin levels were positively related to FM% as estimated by both BIA and anthropometry, independently of age in both sexes; in addition, a positive correlation with WHR and with the subscapular to triceps skinfold thickness ratio (SS/TS) was found in men and women, respectively. No significant correlation was apparent between DHEA-S and body composition indices in men, whereas in women a slight negative correlation between DHEA-S and WHR was documented, and was still significant after adjustment for age and fasting insulin. Stepwise multiple regression analysis confirmed that DHEA-S levels are not related to fasting insulin, but are independently related to age and, in women only, to WHR. Our study suggests that the DHEA-S decline due to aging is independent of fasting insulin, at least in healthy, non-obese people. In addition, it is not related to the aging-dependent changes in body composition in terms of FM% and fat-free mass (FFM) percentage (FFM%). Only in women could changes in fat distribution be slightly associated with DHEA-S decline, although such a relation cannot be accounted for by changes in insulin levels.
- Published
- 1997
- Full Text
- View/download PDF
208. Escaping the cave to dream new dreams: a normative vision for learning disabilities.
- Author
-
Denti LG and Katz MS
- Subjects
- Education, Special standards, Education, Special trends, Humans, Teaching, Learning Disabilities
- Abstract
This essay is predicated on two beliefs: (a) that special educators must critically examine the dominant view of reality undergirding the field of learning disabilities to see the false images built into it, and (b) we must seek a new, empowering vision of the purposes of education as we move into the twenty-first century. The purpose of the article is to analyze how the dominant image of reality in the field of learning disabilities is derived from the diagnostic model, and to propose an alternative, normative conception of education that emphasizes the importance of caring, social relatedness, and community participation.
- Published
- 1995
- Full Text
- View/download PDF
209. Lipoprotein Lp(a) and cerebrovascular disease in the elderly: correlations with the severity of extracranial carotid atherosclerosis assessed by ultrasonography.
- Author
-
Denti L, Marchini L, Pasolini G, Baffoni MT, Ablondi F, and Valenti G
- Subjects
- Aged, Aged, 80 and over, Analysis of Variance, Arteriosclerosis diagnostic imaging, Carotid Artery Diseases diagnostic imaging, Carotid Artery, Common diagnostic imaging, Carotid Artery, Internal diagnostic imaging, Cerebrovascular Disorders diagnostic imaging, Humans, Regression Analysis, Risk Factors, Statistics, Nonparametric, Ultrasonography, Arteriosclerosis blood, Carotid Artery Diseases blood, Cerebrovascular Disorders blood, Lipoprotein(a) blood
- Abstract
High levels of lipoprotein Lp(a) are related to cerebrovascular disease clinical manifestations, as well as to the severity of extracranial carotid atherosclerosis assessed by ultrasonography. In order to investigate the relationship of Lp(a) to the severity of carotid atherosclerosis in the elderly, 100 subjects, aged 78.5 +/- 0.6 yrs underwent an echo-color-doppler scanning of carotids; atherosclerosis severity, assessed as maximum percentage stenosis, presence of complicated plaque and Intima-Media Thickness (IMT), was related to Lp(a) levels, assayed by an immunoenzymatic procedure. A slight association between Lp(a) and CVD clinical manifestations was apparent only in subjects under 78 yrs and for Lp(a) values above 25 mg/dL. Lp(a) levels were not related either to the degree of stenosis, the presence of complicated plaque, or IMT. As for other selected risk factors, while no relationship was found for clinical CVD and IMT, the maximum percentage of stenosis and the presence of complicated plaques were positively related to LDL-cholesterol in subjects under 78 yrs. We can conclude that Lp(a), albeit unrelated to the severity of extracranial vessel atherosclerosis, maintains a role as cerebrovascular risk factor in the elderly, being slightly related to clinical manifestations; however its discriminant power is lower than in middle-aged people and further decreases throughout ageing.
- Published
- 1995
210. Correlation between plasma lipoprotein Lp(a) and sex hormone concentrations: a cross-sectional study in healthy males.
- Author
-
Denti L, Pasolini G, Ablondi F, and Valenti G
- Subjects
- Adult, Aged, Aged, 80 and over, Aging blood, Cholesterol, LDL blood, Dehydroepiandrosterone blood, Humans, Male, Middle Aged, Nutritional Status, Sex Hormone-Binding Globulin metabolism, Gonadal Steroid Hormones blood, Lipoprotein(a) blood
- Abstract
High concentrations of lipoprotein Lp(a) have been related to atherosclerotic disease, both at coronary and cerebrovascular levels. Although Lp(a) levels are under a strict genetic control, being inversely related to the molecular weight of apo(a) isoforms, an interference of endogenous sex steroids on Lp(a) metabolism has been hypothesized. The aim of this study was to investigate the interrelationship between plasma Lp(a) and sex hormone concentrations in 98 healthy males, controlled as for their nutritional status by anthropometric measurements. Statistical evaluation was performed employing simple and multiple stepwise regression analysis. No significant correlation was found between Lp(a) levels and fT, E2 and gonadotropins, while they were positively and independently related to LDL-cholesterol and DHEA-S. As for the other lipoproteins, a positive correlation between HDL-cholesterol and E2 and an inverse correlation between triglycerides and SHBG were observed. These data suggest that endogenous testosterone and estradiol do not affect Lp(a) metabolism in males, at least in physiological concentrations. However Lp(a) might be affected by DHEA-S, the most abundant product of the adrenal gland. The positive correlation of HDL-cholesterol to E2 suggests that estrogens play a major role in lipid metabolism also in males, in spite of their low concentrations; more complex to be explained is the finding of an inverse relationship between Tg and SHBG. Further studies are needed in order to clarify the influence of sex steroids on lipid metabolism, mainly on Lp(a), under physiological conditions; population samples homogeneous in terms of apo a isoforms could be the ideal objects of such studies, in order to avoid the great interindividual variability of Lp(a) concentrations.
- Published
- 1994
- Full Text
- View/download PDF
211. Effects of cytidine 5'-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects.
- Author
-
Ceda GP, Ceresini G, Denti L, Magnani D, Marchini L, Valenti G, and Hoffman AR
- Subjects
- Aged, Aged, 80 and over, Aging physiology, Cytidine Diphosphate Choline administration & dosage, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Pituitary Gland, Anterior drug effects, Pituitary Gland, Anterior metabolism, Cytidine Diphosphate Choline pharmacology, Growth Hormone metabolism, Growth Hormone-Releasing Hormone pharmacology
- Abstract
The basal and GH-releasing hormone-stimulated secretion of GH declines in the elderly. We tested the ability of cytidine 5'-diphosphocholine, a drug used in the treatment of stroke and Parkinson's disease, to alter GH secretion in 11 healthy elderly volunteers, aged 69-84. Each subject received an iv infusion of 2 g of cytidine 5'-diphosphocholine or normal saline. GHRH and TRH were also administered during cytidine 5'-diphosphocholine infusions. The infusion of cytidine 5'-diphosphocholine induced a 4-fold (p less than 0.05) increase in serum GH levels over basal values. A small increase in GH was seen after GHRH administration. However, the addition of GHRH to the cytidine 5'-diphosphocholine infusion resulted in a GH response which was significantly greater than that seen after GHRH alone; the integrated concentration of GH was more than 2-fold greater in the cytidine 5'-diphosphocholine treated group (706.85 +/- 185.1 vs 248.9 +/- 61.4 micrograms.l-1.(120 min)-1; p = 0.01). The PRL and TSH responses to TRH were not significantly affected by cytidine 5'-diphosphocholine infusion, indicating that dopaminergic mechanisms are not involved. These studies demonstrate that cytidine 5'-diphosphocholine can enhance basal and GHRH-stimulated GH release in the elderly, but the mechanism of action of the drug remains unclear.
- Published
- 1991
- Full Text
- View/download PDF
212. The effects of aging on the secretion of the common alpha-subunit of the glycoprotein hormones in men.
- Author
-
Ceda GP, Denti L, Ceresini G, Torsiglieri W, Hoffman AR, and Valenti G
- Subjects
- Adult, Aged, Aged, 80 and over, Glycoprotein Hormones, alpha Subunit biosynthesis, Gonadotropin-Releasing Hormone pharmacology, Humans, Immunoradiometric Assay, Luteinizing Hormone biosynthesis, Luteinizing Hormone drug effects, Male, Middle Aged, Radioimmunoassay, Testosterone biosynthesis, Aging blood, Glycoprotein Hormones, alpha Subunit blood, Luteinizing Hormone blood, Testosterone blood
- Abstract
To investigate the effects of aging on the secretion of the common alpha-subunit of the glycoprotein hormones, we measured basal levels of luteinizing hormone (LH), testosterone (T) and alpha-subunit in 176 normal men aged 19 to 89 years. In addition, in two groups of young (less than 65 years; n = 25) and old (greater than 65 years; n = 15) subjects, the effects of luteinizing hormone-releasing hormone (LHRH) on LH and alpha-subunit secretion were determined. Age-related increases in serum alpha-subunit and LH were noted only in the oldest men while T levels decreased progressively with advancing age. LHRH stimulation resulted in significantly greater secretion of alpha-subunit in the old subjects while no difference in LH release between young and old men was observed. Moreover, there was a delay to peak LH and alpha-subunit levels after LHRH in the old subjects. These data suggest that the aging process in males involves deficits in both testicular and gonadotroph functions as demonstrated by (1) the relative hypogonadotropic hypogonadism seen until the ninth decade; (2) the hypergonadotropic hypogonadism apparent in men greater than 80 years; (3) the delay in the timing of peak responses of LH and alpha-subunit after LHRH administration; and (4) the disproportionate increase in the secretion of alpha subunit relative to intact LH.
- Published
- 1991
- Full Text
- View/download PDF
213. Gonadotropin secretion in hyperthyroidism and hypothyroidism.
- Author
-
Valenti G, Ceda GP, Denti L, Tarditi E, and Speroni G
- Subjects
- Adult, Aged, Female, Follicle Stimulating Hormone metabolism, Graves Disease blood, Humans, Hypothyroidism blood, Luteinizing Hormone metabolism, Male, Menopause, Middle Aged, Radioimmunoassay, Thyrotropin physiology, Thyroxine physiology, Triiodothyronine physiology, Gonadotropins, Pituitary metabolism, Graves Disease physiopathology, Hypothyroidism physiopathology
- Abstract
Gonadotropin patterns were evaluated in a group of 70 patients of both sexes with Graves' disease or primary hypothyroidism. Significant variations were found only in hyperthyroidism where increased basal and stimulated values of both gonadotropins, but particularly LH, occurred. Qualitative and quantitative recovery was seen when euthyroid states were achieved after treatment of hyper- and hypothyroid patients. Interactions with gonadotropin behavior were found in both sexes and in women of different ages. Direct interference on the hypothalamo-pituitary system rather than through the modulation of peripheral estrogen metabolism is suggested as the possible pathogenetic mechanism.
- Published
- 1984
- Full Text
- View/download PDF
214. [Value of angiography and echotomography in injuries of the spleen].
- Author
-
Ugolotti U, Mandrioli R, Miselli A, Rossi A, Marchesi G, and Denti L
- Subjects
- Hematoma diagnosis, Humans, Splenic Infarction diagnosis, Tomography methods, Angiography, Spleen injuries, Splenic Rupture diagnosis, Ultrasonography
- Abstract
In all the patients was performed angiography, while only 11 were studied by the means of Abdominal Ultrasonography. The Authors' aim is to evaluate the accuracy of these two methods and to define a correct diagnostic procedure. The results obtained with Angiography were 15 correct diagnosis and 1 false positive, whereas those obtained with Sonography were 7 correct diagnosis, 2 indicative diagnosis and 2 false negative. Therefore, when a patient is clinically suspected of having a traumatic spleen injury, the Authors suggest to perform an Abdominal Sonography at first. In case of evident spleen lesion, laparatomy will be directly carried out. However, if the sonographic result is negative or aspecific, it will be necessary for the patient to undergo Angiography in order to rule out possible false negative or establish the origin of endoabdominal bleeding correctly.
- Published
- 1983
215. [Disorders of canalization of the afferent loop in patients with gastric resection].
- Author
-
Battistini C, Sivelli R, and Denti L
- Subjects
- Diarrhea etiology, Duodenal Ulcer complications, Humans, Intestinal Fistula complications, Intestinal Obstruction complications, Vomiting etiology, Afferent Loop Syndrome etiology, Afferent Loop Syndrome surgery, Postgastrectomy Syndromes
- Published
- 1975
216. [Thyroid and adrenal response to acute stimulation with HCG: effects of bilateral ovariectomy].
- Author
-
Banchini A, Zavaroni D, Denti L, Tridenti G, Benassi L, and Valenti G
- Subjects
- Adult, Circadian Rhythm, Dehydroepiandrosterone analogs & derivatives, Dehydroepiandrosterone blood, Dehydroepiandrosterone Sulfate, Female, Humans, Hydrocortisone blood, Middle Aged, Chorionic Gonadotropin pharmacology, Ovariectomy, Thyroxine blood, Triiodothyronine blood
- Published
- 1988
217. [Thyroid and adrenal responses to acute stimulation with HCG. Effects of bilateral orchiectomy].
- Author
-
Valenti G, Banchini A, Zavaroni D, Denti L, Pelliccioni P, Ronchini P, and Bompani R
- Subjects
- Adolescent, Adult, Androgens blood, Chorionic Gonadotropin administration & dosage, Humans, Hydrocortisone blood, Male, Middle Aged, Thyroid Hormones blood, Adrenal Glands drug effects, Castration, Chorionic Gonadotropin pharmacology, Thyroid Gland drug effects
- Published
- 1984
218. [Minimal carcinoma of the breast].
- Author
-
Saccani Jotti G, Denti L, Palli D, Rusca M, and Rusconi A
- Subjects
- Breast Neoplasms diagnostic imaging, Breast Neoplasms therapy, Carcinoma diagnostic imaging, Carcinoma therapy, Female, Humans, Lymphatic Metastasis, Prognosis, Radiography, Breast Neoplasms pathology, Carcinoma pathology
- Abstract
For many years pathologists have argued about the definition and the biologic reasons of what is "early", "minimal" and "occult" breast cancer. Whether these terms really identify entities which today can be meaningful to clinicians and whether the prognostic significance of breast cancer measuring 1 cm or less in diameter should have implications in the treatment decision making will form the subject of this review.
- Published
- 1986
219. Obstacles to integrating disabled students in a "two-roof" elementary school.
- Author
-
Mercer JR and Denti L
- Subjects
- Adolescent, Child, Child, Preschool, Disabled Persons education, Education of Intellectually Disabled, Humans, Education, Special, Interpersonal Relations, Schools organization & administration
- Abstract
This article describes a 5-year effort to integrate special and regular students on a campus where special and regular education students are housed in separate but adjacent facilities with separate administrators. Observational data and questionnaires revealed almost total segregation at the end of 3 years. An intensive intervention program, Project L.E.A.D., generated promising short-term movement toward integration, but there were few enduring effects. Physical, social, and psychological barriers created by the two-roof school erect almost insurmountable obstacles to integration. Future efforts should concentrate on building one-roof schools with a single facility and administration.
- Published
- 1989
- Full Text
- View/download PDF
220. The role of overweight and glucose tolerance in the impaired pituitary-gonadal axis of obese males.
- Author
-
Valenti G, Denti L, and Banchini A
- Subjects
- Adult, Chorionic Gonadotropin blood, Estradiol blood, Estrone blood, Glucose Tolerance Test, Humans, Male, Prolactin blood, Sex Hormone-Binding Globulin analysis, Testosterone blood, Obesity physiopathology, Pituitary Gland physiopathology, Testis physiopathology
- Abstract
In a group of 30 obese male patients (160.2% of ideal body weight), an impaired function of the pituitary-gonadal axis has been demonstrated. Decreased testosterone and increased estradiol basal levels, increased LH and FHS responsiveness to gonadotropin-releasing hormone, and increased basal prolactin (PRL) levels are the most significant findings. The overweight factor seems to account for the documented decreased testosterone and increased estrogen levels through a modulation of peripheral steroid metabolism. These peripheral steroid patterns might affect gonadotropin and PRL secretions as well; nevertheless an interference with the metabolism of cerebral neurotransmitters, perhaps related to a nutritional component (impaired glucose tolerance), cannot be completely excluded.
- Published
- 1986
- Full Text
- View/download PDF
221. [Technical notes on mastectomy operations and axillary lymph-node excision with preservation of the pectoralis muscles].
- Author
-
Dell'Anna B and Denti L
- Subjects
- Adult, Axilla surgery, Evaluation Studies as Topic, Female, Humans, Prognosis, Breast Neoplasms surgery, Lymph Node Excision, Mastectomy methods, Pectoralis Muscles
- Published
- 1974
222. Calcitonin inhibition of growth hormone-releasing hormone-induced GH secretion in normal men.
- Author
-
Ceda GP, Denti L, Ceresini G, Rastelli G, Dotti C, Cavalieri S, Valenti G, and Hoffman AR
- Subjects
- Adrenocorticotropic Hormone metabolism, Adult, Animals, Blood Glucose analysis, Fatty Acids, Nonesterified blood, Humans, Hydrocortisone blood, Hypothalamo-Hypophyseal System drug effects, Insulin blood, Male, Middle Aged, Pituitary Gland, Anterior drug effects, Pituitary-Adrenal System drug effects, Rats, Rats, Inbred Strains, beta-Endorphin blood, Calcitonin administration & dosage, Growth Hormone metabolism, Growth Hormone-Releasing Hormone pharmacology
- Abstract
Calcitonin has been shown to modulate pituitary hormone secretion in a variety of ways. In this study we examined the effects of a salmon calcitonin infusion on GHRH-induced GH secretion in 5 normal men. In addition, in vitro experiments were performed using primary cultures of rat anterior pituitary cells in order to examine whether there is a direct pituitary effect of CT. Infusion of CT significantly blunted the GH response to GHRH in all subjects without affecting basal GH secretion or plasma calcium levels. Infusion of CT was accompanied by significant increases in ACTH, beta-endorphin, cortisol and free fatty acid levels, and by a significant decrease in serum insulin levels. The addition of CT to primary cultures of rat pituitary cells did not alter basal or stimulated secretion of GH or ACTH. These results indicate that: 1) CT blunts the GH response to GHRH; 2) CT infusion results in the stimulation of the hypothalamic-pituitary-adrenal axis, and 3) this effect is probably exerted at the hypothalamic level, since no direct activity of CT was documented in vitro on either GH or ACTH secretion.
- Published
- 1989
- Full Text
- View/download PDF
223. [The alpha subunit of glycoprotein hormones].
- Author
-
Denti L, Ceda GP, and Valenti G
- Subjects
- Animals, Chemical Phenomena, Chemistry, Glycoprotein Hormones, alpha Subunit blood, Glycoprotein Hormones, alpha Subunit genetics, Humans, Glycoprotein Hormones, alpha Subunit biosynthesis
- Published
- 1988
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.