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Abstract Background To estimate the incidence, risk factors, and impact on mortality and functional outcomes for early coagulopathy after the return of spontaneous circulation (ROSC) in pediatric out-of-hospital cardiac arrest (OHCA) patients. Methods A post hoc analysis of the Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital (THAPCA-OH) trial was conducted. Early coagulopathy was defined as presence of at least one of the following coagulation abnormalities upon admission: international standard ratio (INR), platelets, and age-adjusted activated partial thromboplastin time (APTT) within 6 h after OHCA and before therapeutic hypothermia initiation. The outcomes included 28-day mortality and functional prognosis. Multivariable logistic regression models were used to explore risk factors and association between early coagulopathy and outcomes. Results Of the 227 patients included, 152 (67%) were male and the median age was 2.3 years [interquartile range (IQR), 0.7–8.6 years]. The overall 28-day mortality was 63%. The incidence of early coagulopathy was 46%. Lower age, longer duration of chest compression, lower temperature, and higher white blood cell (WBC) upon admission increased the risk of early coagulopathy. Early coagulopathy [OR, 2.20 (95% CI, 1.12–4.39), P = 0.023] was independently associated with 28-day mortality after adjusting for confounders. Conclusions Early coagulopathy occurred in almost half of pediatric patients with OHCA. Lower age, longer duration of chest compression, lower temperature, and higher WBC increased the risk. The development of early coagulopathy was independently associated with increased mortality.

Thermoelectric material is capable of realizing direct conversion between heat and electricity. Here, the authors obtain high thermoelectric performance in PbSe at low-medium temperatures by importing dense dislocations.

The wide-bandgap cubic-structure semiconductor In4SnSe4 can be regarded as a product of compositing two typical layered thermoelectric materials SnSe and In4Se3. Remarkably, In4SnSe4 inherited low thermal conductivity from its parent materials. To advance the potential thermoelectric property of In4SnSe4, we systematically investigated its crystal structure and the origin of the intrinsic low thermal conductivity. In4SnSe4 crystallized in a cubic phase (space group Pa3¯), with the lattice parameters of a = b = c = 12.66 Å. The anisotropy of InSe bonds in the lattice determined the complex structure of In4SnSe4 with 72 atoms in the primitive cell. More importantly, sound velocity and elastic properties unclosed the strong anharmonicity in In4SnSe4, which contributed greatly to the low thermal conductivity. With first-principles calculations, it was found that the lone-pair electrons from In+ mainly caused the anharmonicity in the lattice. Additionally, Br was proved to be an effective dopant for In4SnSe4 to improve the electrical transport properties. This work indicated that the complex wide-bandgap semiconductor In4SnSe4 with cubic phase and intrinsic low thermal conductivity was a new promising thermoelectric material with appropriate doping.

Abstract Background Obesity is an important risk factor for hyperuricemia. We aimed to explore the relationship between perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Methods This was a cross-sectional study involving 257 patients with T2DM recruited from Beijing Luhe Hospital from September 2019 to May 2020. The basic and clinical information such as age, gender, duration of diabetes was collected through the medical records. All patients underwent a physical examination including height, weight, waist circumference, hip circumference, systolic blood pressures and diastolic blood pressure. The venous blood and urine samples were collected to measure SUA, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, serum creatinine, blood urea nitrogen and glycosylated hemoglobin. PrFT and PnFT were measured via ultrasonography. Pearson correlation test and linear regression analysis were used to analyze the association between PrFT and PnFT and SUA. Results We found that PrFT and PnFT increased according to the tertiles of SUA level (P = 0.001 and P = 0.009, respectively). In addition, the PrFT and PnFT were positively associated with SUA level (r = 0.25, P

In order to improve the accuracy of hydrological models for runoff prediction and to solve the problem of disappearing time series data break or data fluctuation due to the extension of time series, monthly runoff data from 1996 to 2015 at the Cuntan hydrological station in the upper reaches of the Yangtze River are used as the basis to develop the annual runoff prediction. Prediction of the five Intrinsic Mode Function (IMF) components and one residual from the Ensemble Empirical Mode Decomposition (EEMD) decomposition used different models of Auto-Regressive Integrated Moving Average Model (ARIMA). Except for the small errors in the first two components, the rest of the ARIMA models are highly fitted. For prediction of runoff in 2014 and 2015 based on EEMD-ARIMA model, the relative errors are 6.26% and −1.17%. Compared with the single ARIMA model and Back Propagation (BP) model, the prediction effect is better, and the prediction method is simple and clear. It is shown that the combined EEMD-ARIMA model is an efficient and useful method for the prediction of annual runoff volume. HIGHLIGHTS The study used 240 months of runoff data from Cuntan hydrological station in the upper reaches of the Yangtze River.; An annual runoff prediction model based on EEMD-ARIMA hybrid method is proposed.; The EEMD-ARIMA model outperforms the EMD-ARIMA, BP, and LSTM models.;

Objectives The optimal treatment strategy remains debatable in patients with atrial fibrillation (AF) and heart failure. Our objectives were to summarise in-hospital therapies and determine factors associated with treatment strategy selections.Design A retrospective study analysing the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation (CCC-AF) project from 2015 to 2019.Setting The CCC-AF project included patients from 151 tertiary and 85 secondary hospitals across 30 provinces in China.Participants Patients with AF and left ventricular systolic dysfunction (LVSD, defined as left ventricular ejection fraction